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Researchers at UCD

David Fennelly

Senior Clinical Lecturer

School Of Medicine
St Vincent's Hospital
Elm Park
Dublin 4

Tel:
Email: david.fennelly@ucd.ie

Professional

         

Conference Contributions

E Fox, D Leahy, R Geraghty, H Mulcahy, J Hyland, D Fennelly, D O'Donoghue, K Sheahan; (2007) Transcriptomic profiling may be useful in predicting recurrence in Stage II colorectal cancer. [Poster Presentation (Refereed)], Irish Association for Cancer Research Annual Meeting, Cork, March, 2007 , 02-MAR-07.
E.J.P. Fox, D.T. Leahy, R. Geraghty, A.M. Lennon, D. Keegan, A. White, H.E. Mulcahy, J.M. Hyland, D. Fennelly, D.P. O'Donoghue, K. Sheahan.; (2005) Differential MLH1 promoter hypermethylation in the identification of sporadic mismatch repair-deficient colorectal cancers. [Poster Presentation (Refereed)], United States and Canadian Academy of Pathology Annual Meeting, San Antonio, Texas, USA. February 2005 , 26-FEB-05.
EJ Fox , D T Leahy, A Lennon, R Geraghty, D Keegan, A White, H E Mulcahy, J M Hyland, D Fennelly, D P O`Donoghue, K Sheahan; (2004) MLH1 and MGMT promoter hypermethylation in colorectal cancer. [Oral Presentation], United States and Canadian Academy of Pathology Annual Meeting, Vancouver, March 2004 , 06-MAR-04.
Nolan, I. M., Fox, E. J. P., Moss, C., Leahy, D. T., Geraghty, R., Mulcahy, H. E., Hyland, J. P. M., Fennelly, D., Sheahan, K., O Donoghue D., Argraves, W. S., and Gallagher, W. M. presented by I. M. Nolan.; (2003) Biomarker identification in colon cancer via real-time reverse transcriptase-PCR. [Poster Presentation], Conference on Common Molecular Mechanisms in Inflammation & Malignancy, St. Vincent?s University Hospital, Dublin , 21-NOV-03.
E.J.P. Fox, A.M. Lennon, D.T. Leahy, R. Geraghty, D. Keegan, H.E. Mulcahy, J.M. Hyland, D. Fennelly, D.P. O'Donoghue, K. Sheahan.; (2003) Clinico-pathological Features in the Identification of Cases of Familial Colorectal Cancer. [N/A], Irish Society of Gastroenterology Spring Meeting, Belfast , 06-JUN-03 - 07-JUN-03.
Nolan, I. M., Fox, E. J. P., Moss, C., Leahy, D. T., Geraghty, R., Mulcahy, H. E., Hyland, J. P. M., Fennelly, D., Sheahan, K., O Donoghue D., Argraves, W. S., and Gallagher, W. M. presented by I. M. Nolan.; (2003) Expression levels of fibulin-1 and 4 mRNA in colon cancer tissues determined by real-time quantitative reverse transcriptase-PCR. [Poster Presentation], 3rd Annual Conway Institute Festival of Research, University College Dublin , 10-SEP-03 - 11-SEP-03.
E.J.P. Fox, A.M. Lennon, D.T. Leahy, R. Geraghty, D. Keegan, H.E. Mulcahy, J.M. Hyland, D. Fennelly, D.P. O'Donoghue, K. Sheahan.; (2003) Epigenetic, Immunohistochemical and Microsatellite Marker Analysis of DNA Mismatch Repair Defects in Colorectal Cancer. [N/A], Irish Association for Cancer Research Annual Meeting, Kilkenny , 11-APR-03 - 13-APR-03.
   

Education

Year Institution:
Qualification: MB Subject:
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Qualification: MRCPI Subject:
Year 2007 Institution:
Qualification: MRCPI Subject:
Year 2007 Institution:
Qualification: MB Subject:
         

Publications

     

Peer Reviewed Journals

Murtagh G, Lyons T;O'Connell E;Ballot J;Geraghty L;Fennelly D;Gullo G;Ledwidge M;Crown J;Gallagher J;Watson C;McDonald KM;Walshe JM (2016) 'Late cardiac effects of chemotherapy in breast cancer survivors treated with adjuvant doxorubicin: 10-year follow-up'. Breast Cancer Research and Treatment, 156 (3):501-506. [DOI] [Details]
Lee CS, Murphy DJ, McMahon C, Nolan B, Cullen G, Mulcahy H, Sheahan K, Barnes E, Fennelly D, Ryan EJ, Doherty GA (2015) 'Visceral Adiposity is a Risk Factor for Poor Prognosis in Colorectal Cancer Patients Receiving Adjuvant Chemotherapy'. Journal of Gastrointestinal Cancer, . [DOI] [Details]
Caiazza F, Elliott L, Fennelly D, Sheahan K, Doherty GA, Ryan EJ (2015) 'Targeting EGFR in metastatic colorectal cancer beyond the limitations of KRAS status: alternative biomarkers and therapeutic strategies'. Biomarkers in Medicine, 9 (4):363-375. [DOI] [Details]
O'Toole A, Michielsen AJ, Nolan B, Tosetto M, Sheahan K, Mulcahy HE, Winter DC, Hyland JM, O'Connell PR, Fennelly D, O'Donoghue D, O'Sullivan J, Doherty GA, Ryan EJ (2014) 'Tumour microenvironment of both early- and late-stage colorectal cancer is equally immunosuppressive'. British Journal of Cancer, . [DOI] [Details]
Martin P, Noonan S, Mullen MP, Scaife C, Tosetto M, Nolan B, Wynne K, Hyland J, Sheahan K, Elia G, O'Donoghue D, Fennelly D, O'Sullivan J. (2014) 'Predicting response to vascular endothelial growth factor inhibitor and chemotherapy in metastatic colorectal cancer'. BMC Cancer, 14 (887). [DOI] [Details]
Tamagno, G. and Sheahan, K. and Skehan, S.J. and Geoghegan, J.G. and Fennelly, D. and Collins, C.D. and Maguire, D. and Traynor, O. and Brophy, D.P. and Cantwell, C. and Swan, N. and McGowan, L. and O'Toole, D. and O'Shea, D. (2013) 'Initial impact of a systematic multidisciplinary approach on the management of patients with gastroenteropancreatic neuroendocrine tumor'. Endocrine, 44 (2):504-509. Available Online [DOI] [Details]
Duignan S, Maguire D;Ravichand CS;Geoghegan J;Hoti E;Fennelly D;Armstrong J;Rock K;Mohan H;Traynor O (2013) 'Neoadjuvant chemoradiotherapy followed by liver transplantation for unresectable cholangiocarcinoma: a single-centre national experience'. HPB, 16 (1):91-98. [DOI] [Details]
Michielsen, A. J., Noonan, S., Martin, P., Tosetto, M., Marry, J., Biniecka, M., Maguire, A. A., Hyland, J. M., Sheahan, K. D., O'Donoghue, D. P., Mulcahy, H. E., Fennelly, D., Ryan, E. J., O'Sullivan, J. N. (2012) 'Inhibition of dendritic cell maturation by the tumor microenvironment correlates with the survival of colorectal cancer patients following bevacizumab treatment'. Molecular Cancer Therapy, 11 (8):1829-37. Available Online [Details]
McHugh JC, Tryfonopoulos D;Fennelly D;Crown J;Connolly S (2012) 'Electroclinical biomarkers of early peripheral neurotoxicity from oxaliplatin'. European Journal of Cancer Care, 21 (6):782-789. [DOI] [Details]
Ward F, Dunne O;Crotty TB;Fennelly D;Watson A;Holian J (2012) 'Successful use of combined high cut-off haemodialysis and bortezomib for acute kidney injury associated with myeloma cast nephropathy'. Irish Medical Journal, 105 (5):148-149. [Details]
Shireen R, Brennan D;Flannelly G;Fennelly D;Lenehan P;Foley M (2012) 'Survival in women with ovarian cancer before and after the introduction of adjuvant paclitaxel; a 25-year, single institution review'. Irish Medical Journal, 105 (2):47-50. [Details]
Kennelly, R.P. and Heeney, A. and White, A. and Fennelly, D. and Sheahan, K. and Hyland, J.M.P. and O'Connell, P.R. and Winter, D.C. (2012) 'A prospective analysis of patient outcome following treatment of T3 rectal cancer with neo-adjuvant chemoradiotherapy and transanal excision'. International Journal of Colorectal Disease, 27 (6):759-764. Available Online [DOI] [Details]
Bambury R, Gallagher F;Dodd JD;Fennelly D (2011) 'Primary cardiac lymphoma: diagnostic tools and treatment challenges'. Irish Journal of Medical Science, 180 (1):271-273. [DOI] [Details]
O'Connor, R.,O'Leary, M.,Ballot, J.,Collins, C. D.,Kinsella, P.,Mager, D. E.,Arnold, R. D.,O'Driscoll, L.,Larkin, A.,Kennedy, S.,Fennelly, D.,Clynes, M.,Crown, J.; (2007) 'A phase I clinical and pharmacokinetic study of the multi-drug resistance protein-1 (MRP-1) inhibitor sulindac, in combination with epirubicin in patients with advanced cancer'. Cancer Chemotherapy and Pharmacology, 59 (1):79-87. Available Online [Details]
Fox, EJ; Leahy, DT; Geraghty, R; Mulcahy, HE; Fennelly, D; Hyland, JM; O'Donoghue, DP; Sheahan, K; ; (2006) 'Mutually exclusive promoter hypermethylation patterns of hMLH1 and O-6-methylguanine DNA methyltransferase in colorectal cancer'. Journal of Molecular Diagnostics, 8 (1):68-75. [Details]
Heffernan E, Fennelly D, Collins CD.; (2006) 'Multiple metastases to skeletal muscle from carcinoma of the esophagus detected by FDG PET-CT imaging'. Clinical Nuclear Medicine, 31 :810-811. [Details]
Kelleher, FC, Fennelly, D, Rafferty, M, ; (2006) 'Common critical pathways in embryogenesis and cancer'. Acta Oncologica, 45 (4):375-388. [Details]
O'Leary, M.,O'Connor, R.,Roy, S.,Ballot, J.,Ooi, W.,Fennelly, D.,Sheehan, L.,Collins, C.,Clynes, M.,Crown, J.; (2004) 'Phase I trial of the multi-drug resistance (MDR) protein-1 (MRP-1) modulating agent sulindac (S) plus epirubicin (E) in patients (pts) with advanced cancer'. Journal of Clinical Oncology, 22 (14):159s-159s. Available Online [Details]
Crown, J.,Fennelly, D.,Collins, C.,Jones, M.,Ennis, S.,Rowan, S.,Flynn, C.,Nutty, S.,Armstrong, J.,Moulton, B.; (2000) 'Mature results of a phase I/II evaluation of docetaxel (T), ifosphamide (I), cisplatin (C) supported by lenograstim (L) in patients (pts) with advanced non-small cell lung cancer (NSCLCa): An Irish Clinical Oncology Research Group (ICORG) study'. Annals of Oncology, 11 :118-119. Available Online [Details]
Crown, J.,Chan, K. M.,O'Leary, M.,Ballot, J.,King, T.,Murphy, J.,Lenehan, P.,Drumm, J.,McCarthy, D.,Fennelly, D.; (1999) 'Feasibility of an accelerated multi-cycle high-dose chemotherapy regimen including high-dose thiotepa for patients (Pts) with poor risk ovarian cancer (OC)'. European Journal of Cancer, 35 :S232-S232. Available Online [Details]
Bourke, T; Carr, A; Fennelly, D; McDermott, E; Crown, J; ; (1998) 'Improved doctor/patient communication indices in oncology: Results of a prospective, controlled evaluation and intervention based on the E4 model'. Annals of Oncology, 9 (NA):141-141. [Details]
Donnellan, P.,Armstrong, J.,Rowan, S.,Fennelly, D.,Lynch, V.,McDonnell, T.,McNicholas, W.,Crown, J.; (1998) 'New chemotherapy combinations with docetaxel in the treatment of patients with non-small cell lung cancer'. Seminars in Oncology, 25 (3):20-23. Available Online [Details]
Hudis, C.,Seidman, A.,Raptis, G.,Fennelly, D.,Gilewski, T.,Baselga, J.,Theodoulou, M.,Sklarin, N.,Moynahan, M.,Surbone, A.,Currie, V.,Lebwohl, D.,Uhlenhopp, M.,Crown, J.,Norton, L.; (1996) 'Sequential adjuvant therapy: The Memorial Sloan-Kettering Cancer Center experience'. Seminars in Oncology, 23 (1):58-64. Available Online [Details]
Crown, J.,Raptis, G.,Hamilton, N.,Fennelly, D.,Vahdat, L.,Norton, L.; (1995) 'High-Dose Chemotherapy of Breast-Cancer - Current Status and Developmental Strategies'. European Journal of Cancer, 31A (5):809-811. Available Online [Details]
Vahdat, L.,Raptis, G.,Fennelly, D.,Crown, J.; (1995) 'High-Dose Chemotherapy of Metastatic Breast-Cancer - a Review'. Cancer Investigation, 13 (5):505-510. Available Online [Details]
Vahdat, L.,Raptis, G.,Fennelly, D.,Hamilton, N.,Reich, L.,Tiersten, A.,Harrison, M.,Hudis, C.,Moore, M.,Yao, T. J.,Norton, L.,Crown, J.; (1995) 'Rapidly cycled courses of high-dose alkylating agents supported by filgrastim and peripheral blood progenitor cells in patients with metastatic breast cancer'. Clinical Cancer Research, 1 (11):1267-1273. Available Online [Details]
Fennelly, D.,Schneider, J.,Spriggs, D.,Bengala, C.,Hakes, T.,Reich, L.,Barakat, R.,Curtin, J.,Moore, M. A. S.,Hoskins, W.,Norton, L.,Crown, J.; (1995) 'Dose-Escalation of Paclitaxel with High-Dose Cyclophosphamide, with Analysis of Progenitor-Cell Mobilization and Hematologic Support of Advanced Ovarian-Cancer Patients Receiving Rapidly Sequenced High-Dose Carboplatin Cyclophosphamide Courses'. Journal of Clinical Oncology, 13 (5):1160-1166. Available Online [Details]
Fennelly, D.,Wasserheit, C.,Schneider, J.,Hakes, T.,Reich, L.,Curtin, J.,Yao, T. J.,Markman, M.,Norton, L.,Crown, J.; (1994) 'Simultaneous Dose-Escalation and Schedule Intensification of Carboplatin-Based Chemotherapy Using Peripheral-Blood Progenitor Cells and Filgrastim - a Phase-I Trial'. Cancer Research, 54 (23):6137-6142. Available Online [Details]
Fennelly, D.,Vahdat, L.,Schneider, J.,Reich, L.,Hamilton, N.,Hakes, T.,Raptis, G.,Wasserheit, C.,Kritz, A.,Gulati, S.,Markman, M.,Hoskins, W.,Norton, L.,Crown, J.; (1994) 'High-Intensity Chemotherapy with Peripheral-Blood Progenitor-Cell Support'. Seminars in Oncology, 21 (2):21-25. Available Online [Details]
Crown, J.,Vahdat, L.,Fennelly, D.,Francis, P.,Wasserheit, C.,Hudis, C.,Kritz, A.,Schneider, J.,Hamilton, N.,Gilewski, T.,Norton, L.; (1993) 'High-Intensity Chemotherapy with Hematopoietic Support in Breast-Cancer'. Breast Cancer: From Biology to Therapy, 698 :378-388. Available Online [Details]
Bengala, C.,Fennelly, D.,Shapiro, F.,Schneider, J.,Reich, L.,Moore, M. A. S.,Norton, L.,Crown, J.; (1993) 'Taxol (Txl) in Combination with Cyclophosphamide (Ctx) and G-Csf Can Improve the Mobilization of Peripheral-Blood Progenitors Cells (Pbpcs) in Untreated Locally Advanced Ovarian-Cancer - Preliminary-Report'. Blood, 82 (10):A82-A82. Available Online [Details]

Other Journals

Nolan, IM; Fox, EJ; Moss, C; Leahy, DT; Geraghty, R; Mulcahy, HE; Hyland, JP; Fennelly, D; Sheahan, K; O'Donoghue, D; Argraves, WS; Gallagher, WM; ; (2004) 'Fibulin-1 and-4 mRNA expression levels in human colorectal cancer' British Journal of Cancer 91 (NA) :70-70. [Details]

Conference Publications

Fox, EJ; Leahy, DT; Geraghty, R; Lennon, AM; Keegan, D; White, A; Mulcahy, HE; Hyland, JM; Fennelly, D; O'Donoghue, DP; Sheahan, K; ; (2005) LABORATORY INVESTIGATION 85: Suppl. 1, 102A Differential MLH1 promoter hypermethylation in the identification of sporadic mismatch repair-deficient colorectal cancers [Details]
Nolan, IM; Fox, EJ; Moss, C; Leahy, DT; Geraghty, R; Mulcahy, HE; Hyland, JP; Fennelly, D; Sheahan, K; O'Donoghue, D; Argraves, WS; Gallagher, WM; ; (2004) BRITISH JOURNAL OF CANCER 91: Suppl. 1, S70 Fibulin-1 and-4 mRNA expression levels in human colorectal cancer [Details]
                                                                                         

Research

 

Research Projects

Sponsor : University College Dublin Foundation Ltd.
Title : Helsinn Birex Newman Fellowship
Start Date / End Date : 02-JUL-12 / 30-JUN-15
Sponsor : University College Dublin Foundation Ltd.
Title : Merck Serono Newman Fellowship EGFR signalling pathways in Colorectal Cancer
Start Date / End Date : 01-APR-13 / 30-JUN-15
Sponsor : University College Dublin (UCD)
Title : Modulation of colorectal cancer tumorigenesis by KHSRP through the tumor microenvironment
Start Date / End Date : 01-APR-15 / 30-SEP-16
Sponsor : University College Dublin Foundation Ltd.
Title : Merck Serono Newman Fellowship in Medical Oncology
Start Date / End Date : 10-JUL-15 / 09-JUL-17
Sponsor : University College Dublin Foundation Ltd.
Title : Newman Fellowship in Colorectal Cancer - Dr Aidan Murphy
Start Date / End Date : 01-JUL-10 / 30-JUN-12
Sponsor : University College Dublin Foundation Ltd.
Title : Importance oflood vessel stability and the vascular environment in governing treatment response to targeted therapies in colorectal cancer patients
Start Date / End Date : 01-MAR-10 / 28-FEB-12
Sponsor : University College Dublin Foundation Ltd.
Title : Importance of mitochondrial random mutations and deletions in governing treatment response to targeted therapies in colorectal cancer patients
Start Date / End Date : 01-MAR-10 / 28-FEB-12
 

Current Postgraduate Students

Louise Elliott, Master of Science (MSc)   -   Thesis Supervisor
Francesco Caiazza, Master of Science (MSc)   -   Thesis Supervisor