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Researchers at UCD

researcher

Deborah Wallace

Clinical Research Tutor

School Of Medicine
Mater Hospital
Eccles Street
Dublin 7

Tel: 353 1 7164586
Email: deborah.wallace@ucd.ie

Professional

Honours and Awards

Year: 2017.
Title: College Teaching Award
Year: 2014.
Title: Barbara Knox Medal
Year: 2012.
Title: Association for Research in Vision and Ophthalmology International Travel Award

Associations

Association: Matrix Biology Ireland , Function/Role: Member
Association: International Society for Eye Research, Function/Role: Member
Association: Association for Research in Vision and Ophthalmology, Function/Role: Member
       

Committees

Committee : CRC Management Committee
Committee : SSRA Committee
Committee : GTPC / PERC for Graduate Certificate in Clinical Research (X649) / MSc in Clinical and Translational Research (X427)

Employment

Employer: University College Dublin
Position: Clinical Research Tutor / Special Lecturer
Employer: Institute of Ophthalmology / University College Dublin
Position: Senior Scientist
Employer: University College Dublin
Position: Post-Doctoral Research Fellow
Employer: Institute of Ophthalmology, Mater Misericordiae University Hospital
Position: Senior Scientist
Employer: University College Cork
Position: Post-Doctoral Researcher

Education

Year 2017 Institution: University College Dublin
Qualification: Prof Cert University Teaching & Learning Subject: University Teaching and Learning
Year 2003 Institution: University College Cork
Qualification: PhD Subject: Biochemistry
Year 1998 Institution: University College Cork
Qualification: BSc. (Hons) Subject: Biochemistry
         

Publications

     

Peer Reviewed Journals

O'Callaghan J, Crosbie DE, Cassidy PS, Sherwood JM, Flügel-Koch C, Lütjen-Drecoll E, Humphries MM, Reina-Torres E, Wallace D, Kiang AS, Campbell M, Daniel SW, Overby DR, O'Brien C, Tam LC, Humphries P. (2017) 'Therapeutic potential of AAV-mediated MMP-3 secretion from corneal endothelium in treating glaucoma'. Human Molecular Genetics, . [DOI] [Details]
Kennelly KP, Holmes TM, Wallace DM, O'Farrelly C, Keegan DJ (2017) 'Early subretinal allograft rejection is characterized by innate immune activity'. Cell Transplantation, . [DOI] [Details]
McDonnell F, Irnaten M;Clark AF;O'Brien CJ;Wallace DM (2016) 'Hypoxia-Induced Changes in DNA Methylation Alter RASAL1 and TGF¿¿1 Expression in Human Trabecular Meshwork Cells'. PLoS ONE, 11 (4). [DOI] [Details]
F. McDonnell, A.F. Clark, C.J. O¿Brien, D.M. Wallace. (2016) 'Increased Global DNA Methylation and Decreased TGFβ1 Promoter Methylation in Glaucomatous Lamina Cribrosa Cells'. Journal of Glaucoma, . [Details]
Quill, B., Irnaten, M., Docherty, N. G., McElnea, E. M., Wallace, D. M., Clark, A. F., O'Brien, C. J. (2015) 'Calcium channel blockade reduces mechanical strain-induced extracellular matrix gene response in lamina cribrosa cells'. British Journal of Ophthalmology, 99 (7):1009-14. Available Online [Details]
Wallace DM, O'Brien CJ (2015) 'The role of lamina cribrosa cells in optic nerve head fibrosis in glaucoma'. Experimental Eye Research, 142 :102-109. [DOI] [Details]
Wallace DM, Pokrovskaya O;O'Brien CJ (2015) 'The Function of Matricellular Proteins in the Lamina Cribrosa and Trabecular Meshwork in Glaucoma'. Journal of Ocular Pharmacology and Therapeutics, 31 (7):386-395. [DOI] [Details]
McElnea, E. M., Hughes, E., McGoldrick, A., McCann, A., Quill, B., Docherty, N., Irnaten, M., Farrell, M., Clark, A. F., O'Brien, C. J., Wallace, D. M. (2014) 'Lipofuscin accumulation and autophagy in glaucomatous human lamina cribrosa cells'. BMC Ophthalmology, 14 :153. Available Online [Details]
O. Pokrovskaya, D. Wallace, C. O¿Brien (2014) 'The Emerging Role of Statins in Glaucoma Pathological Mechanisms and Therapeutics'. Open Ophthalmology Journal, . [Details]
Wallace DM, Murphy-Ullrich JE;Downs JC;O'Brien CJ (2014) 'The role of matricellular proteins in glaucoma'. Matrix Biology, 37 :174-182. [DOI] [Details]
McDonnell F, O'Brien C;Wallace D (2014) 'The role of epigenetics in the fibrotic processes associated with glaucoma'. Ophthalmology, 2014 . [DOI] [Details]
Irnaten, M., Barry, R. C., Wallace, D. M., Docherty, N. G., Quill, B., Clark, A. F., O'Brien, C. J. (2013) 'Elevated maxi-K(+) ion channel current in glaucomatous lamina cribrosa cells'. Experimental Eye Research, 115 :224-9. Available Online [Details]
Wallace DM, Clark AF;Lipson KE;Andrews D;Crean JK;O'Brien CJ (2013) 'Anti-connective tissue growth factor antibody treatment reduces extracellular matrix production in trabecular meshwork and lamina cribrosa cells'. Investigative Ophthalmology and Visual Science, 54 (13):7836-7848. [DOI] [Details]
McElnea, E. M., Quill, B., Docherty, N. G., Irnaten, M., Siah, W. F., Clark, A. F., O'Brien, C. J., Wallace, D. M. (2011) 'Oxidative stress, mitochondrial dysfunction and calcium overload in human lamina cribrosa cells from glaucoma donors'. Mol Vis, 17 :1182-91. Available Online [Details]
K.P. Kennelly, D.M.Wallace, T.M. Holmes, D.J. Hankey, C. O¿Farrelly, D.J. Keegan (2011) 'Preparation of Pre-Confluent Retinal Cells Increases Graft Viability in Vitro and In Vivo'. PLoS ONE, . [DOI] [Details]
Dervan EW, Chen H, Ho SL, Brummel N, Schmid J, Toomey D, Haralambova M, Gould E, Wallace DM, Prehn JH, O'Brien CJ, Murphy D (2010) 'Protein macroarray profiling of serum autoantibodies in pseudoexfoliation glaucoma'. Investigative Ophthalmology and Visual Science, . [Details]
Arroba AI, Wallace D, Mackey A, de la Rosa EJ, Cotter TG (2009) 'IGF-I maintains calpastatin expression and attenuates apoptosis in several models of photoreceptor cell death'. European Journal of Neuroscience, . [Details]
Doonan F, Wallace D.M, O'Driscoll C, Cotter TG (2009) 'Rosiglitazone acts as a neuroprotectant in retinal cells via up-regulation of sestrin-1 and SOD-2'. Journal of Neurochemistry, . [Details]
Wallace D.M, Cotter TG (2009) 'Histone deacetylase activity in conjunction with E2F-1 and p53 regulates Apaf-1 expression in 661W cells and the retina'. Journal of Neuroscience, . [Details]
O'Connor JC, Wallace D.M, O'Brien CJ, Cotter TG. (2008) 'A novel antioxidant function for the tumor-suppressor gene p53 in the retinal ganglion cell'. Investigative Ophthalmology and Visual Science, . [Details]
Mackey AM, Sanvicens N, Groeger G, Doonan F, Wallace D, Cotter TG (2008) 'Redox survival signalling in retina-derived 661W cells'. Cell Death and Differentiation, . [Details]
O'Driscoll C, Wallace D, Cotter TG (2007) 'bFGF promotes photoreceptor cell survival in vitro by PKA-mediated inactivation of glycogen synthase kinase 3beta and CREB-dependent Bcl-2 up-regulation'. Journal of Neurochemistry, . [Details]
Wallace D.M, Donovan M, Cotter TG (2006) 'Histone deacetylase activity regulates apaf-1 and caspase 3 expression in the developing mouse retina'. Investigative Ophthalmology and Visual Science, . [Details]
Wallace D.M. Lindsay AJ, Hendrick AG and McCaffrey MW (2002) 'Rab11-FIP4 interacts with Rab11 in a GTP-dependent manner and its overexpression condenses the Rab11 positive compartment in HeLa cells'. Biochemical and Biophysical Research Communications, . [Details]
Wallace D.M. Lindsay AJ and McCaffrey (2002) 'The novel Rab11-FIP/Rip/RCP family of proteins displays extensive homo- and hetero-interacting abilities'. Biochemical and Biophysical Research Communications, . [Details]
                                                                                                                                           

Research

Research Interests

Our laboratory is interested in the role of fibrosis in glaucoma. Glaucoma affects over 60 million people worldwide however current treatments are still limited & anti-fibrotic approaches remain largely unexplored. We have an active research group based at the CRC MMUH investigating glaucoma associated fibrosis through areas such as pathological cell biology and control mechanisms such as epigenetics. By way of active collaborations both within UCD and internationally we endeavour to develop anti-fibrotic therapies.

 


Research Projects

Sponsor : University College Dublin (UCD)
Title : To Investigate the Role of Methylation in the Regulation of Lysyl Oxidase Like 1 expression in Pseudoexfoliation Glaucoma
Start Date / End Date : 01-APR-17 / 30-SEP-18
Sponsor : University College Dublin (UCD)
Title : OBRSS Research Support Scheme
Start Date / End Date : 01-NOV-16 / 31-OCT-19
Sponsor : University College Dublin (UCD)
Title : Connective Tissue Growth Factor Induction of Lysl Oxidase (LOX) Enzyme Expression in Human Trabecular Meshwork Cells is reduced by FG-3019
Start Date / End Date : 01-MAY-13 / 31-OCT-14
Sponsor : Health Research Board (HRB)
Title : Glaucoma: An Insight into Epigenomic Reprogramming
Start Date / End Date : 01-DEC-11 / 31-DEC-14

Recent Postgraduates

E. Dervan  (MD) 2011

K. Kennelly (PhD) 2012

B. Quill (MD) 2012

S. Farrell (MD) 2013

E. McElnea (MD) 2013

E. Hughes (MD) 2014

F. McDonnell (PhD) 2015

O. Pokrovskaya (MD) 2016 

 

Teaching

Teaching Philosophy

I ensure that my teaching is highly research-focused

Modules Coordinated

201700   MDCS41630     Medicine Clinical Science: Clin & Translational Research
201700   MDCS41890     Medicine Clinical Science: Principles of Lab Medicine
201700   MDCS41950     Medicine Clinical Science: Biostatistics &Data Management

Enhancement of Teaching

Learning to Teach; Teaching to Learn SILS IS50060 Jan-May 2013 (Cert). Programme Design: Graduate Taught (Pt 1) 22 Oct 2014, UCD Teaching & Learning Introduction To Pbl-Curriculum Design 07 Feb 2014, UCD Teaching & Learning Working With Large Undergraduate Classes 19 Nov 2013, UCD Teaching & Learning

Review and Enhancement of Curriculum

Curriculum review 2015-16; Graduate Certificate in Clinical Research / MSc Clinical and Translational Research. Curriculum development of Online Graduate Certificate in Clinical Trials

Developing as a Teacher

UTL40220 Embedding Research in Teaching & UTL40140 Assessing for Teaching and Learning in Higher Education completed for PCTLE001 (Professional Cert in UTL). Currently completing Prof. Diploma in UTL.
 

Collaborators

Internal Collaborators

  • Dr. John Crean, University College Dublin, Ireland
  • Dr. Amanda McCann, University College Dublin, Ireland
  • Dr. Neil Docherty, University College Dublin, Ireland
  • Prof. Peter Humphries, Trinity College Dublin, Ireland

External Collaborators

  • Prof. Abbot Clark, University of North Texas, USA
  • Prof. J. Crawford Downs, University of Alabama at Birmingham, USA
  • Prof. J. Murphy-Ullrich, University of Alabama at Birmingham, USA
  • Prof. Colin Willoughby, University of Liverpool, United Kingdom
  • Dr. Michael Elliott, University of Oklahoma, USA