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Researchers at UCD

Denise Sadlier

Senior Clinical Lecturer

School Of Medicine
Mater Hospital
Eccles Street
Dublin 7

Tel: +353 1 7164568
Email: denise.sadlier@ucd.ie

Professional

               

Education

Year 1998 Institution:
Qualification: MRCPI Subject:
Year 1996 Institution: University College Dublin
Qualification: MB, BCh, BAO Subject:
         

Publications

Books

Sadlier, D.M. and O'Meara, Y.M. (2010) Recurrent and De Novo Renal Diseases After Kidney Transplantation. : Elsevier Inc. [DOI] [Details]

Book Chapters

Ryan A, Sadlier, DM and Godson C Animal models of glomerulonphritis. In Fundamentals of Inflammation, Serhan, Ward and Gilroy (Eds.) Cambridge University Press, In press 2009; (2010) 'Animal models of glomerulonphritis' In: Ryan A, Sadlier, DM and Godson C Animal models of glomerulonphritis. In Fundamentals of Inflammation, Serhan, Ward and Gilroy (Eds.) Cambridge University Press, In press 2009; (eds). Fundamentals of Inflammation. NY: Cambridge University Press. [Details]
Sadlier DM, O'Meara YM; (2009) 'Recurrent and De Novo Renal Diseases after Kidney Transplantation' In: Himmelfarb J, Sayegh MH (eds). Chronic Kidney Disease, Dialysis, and Transplantation: A Companion to Brenner and Rectors¿ The Kidney. Philadelphia: Elsevier. [Details]
Sadlier D, O¿Meara Y M. ; (2005) 'Recurrent and de novo renal disease in kidney transplantation' In: Pereira BJ and Sayegh MH., Blake P. W.B. Saunders Co. Philadelphia, pp708-721, 2005 (eds). Chronic Kidney Disease, Dialysis, and Transplantation: A Companion to Brenner and Rectors¿ The Kidney. Philadelphia: W.B. Saunders Co. , pp.708-721 [Details]
 

Peer Reviewed Journals

Todd JN, Dahlstr¿¿m EH;Salem RM;Sandholm N;Forsblom C; ;McKnight AJ;Maxwell AP;Brennan E;Sadlier D;Godson C;Groop PH;Hirschhorn JN;Florez JC (2015) 'Genetic Evidence for a Causal Role of Obesity in Diabetic Kidney Disease'. Journal of Diabetes, . [DOI] [Details]
O'Sullivan KE, Byrne JS;Hudson A;Murphy AM;Sadlier DM;Hurley JP (2015) 'The effect of obesity on acute kidney injury after cardiac surgery'. Journal of Thoracic and Cardiovascular Surgery, . [DOI] [Details]
Brennan, E; McEvoy, C; Sadlier, D; Godson, C; Martin, F (2013) 'The genetics of diabetic nephropathy'. Genes, . [Details]
Neff KJ, Frankel AH;Tam FW;Sadlier DM;Godson C;le Roux CW (2013) 'The effect of bariatric surgery on renal function and disease: a focus on outcomes and inflammation'. Nephrology, Dialysis and Transplantation, 28 Suppl 4 :1-82. [DOI] [Details]
Brennan, E. P., Nolan, K. A., Borgeson, E., Gough, O. S., McEvoy, C. M., Docherty, N. G., Higgins, D. F., Murphy, M., Sadlier, D. M., Ali-Shah, S. T., Guiry, P. J., Savage, D. A., Maxwell, A. P., Martin, F., Godson, C., Genie Consortium (2013) 'Lipoxins attenuate renal fibrosis by inducing let-7c and suppressing TGFbetaR1'. Journal of the American Society of Nephrology : JASN, 24 (4):627-37. Available Online [Details]
Brennan EP, Morine MJ, Walsh DW, Roxburgh SA, Lindenmeyer MT, Brazil DP, Gaora PO, Roche HM, Sadlier DM, Cohen CD, Godson C, Martin F (2012) 'Next-generation sequencing identifies TGF-β1-associated gene expression profiles in renal epithelial cells reiterated in human diabetic nephropathy'. Biochimica et biophysica acta, 1822 (4):589-599. [DOI] [Details]
Bennett G, Sadlier D, Doran PP, Macmathuna P, Murray DW; (2011) 'A functional and transcriptomic analysis of NET1 bioactivity in gastric cancer'. BMC Cancer, 11 . [DOI] [Details]
Rooney, B,O'Donovan, H,Gaffney, A,Browne, M,Faherty, N,Curran, SP,Sadlier, D,Godson, C,Brazil, DP,Crean, J; (2011) 'CTGF/CCN2 activates canonical Wnt signalling in mesangial cells through LRP6: Implications for the pathogenesis of diabetic nephropathy'. FEBS Letters, 585 :531-538. [DOI] [Details]
Rooney B, O'Donovan, H., Browne, M., Gaffney, A., Curran, SP., Brazil, DP. Godson, C., Sadlier, D and Crean, JK. ; (2010) 'CTGF/CCN2 activates canonical Wnt signaling in mesangial cells through LRP6; implications for the pathogenesis of diabetic nephropathy'. European journal of biochemistry / FEBS, . [Details]
Pettigrew, KA,McKnight, AJ,Patterson, CC,Kilner, J,Sadlier, DM,Maxwell, AP; (2010) 'Resequencing of the CCL5 and CCR5 genes and investigation of variants for association with diabetic nephropathy'. Gene, 55 :248-251. [DOI] [Details]
McKnight, AJ,Patterson, CC,Pettigrew, KA,Savage, DA,Kilner, J,Murphy, M,Sadlier, D,Maxwell, AP,Warren 3 UK Genetics Kidneys Diab; (2010) 'A GREM1 Gene Variant Associates with Diabetic Nephropathy'. Journal of the American Society of Nephrology : JASN, 21 :773-781. [DOI] [Details]
McKnight, AJ,Pettigrew, KA,Patterson, CC,Kilner, J,Sadlier, DM,Maxwell, AP,Warren 3 UK GoKinD Study Grp; (2010) 'Investigation of the association of BMP gene variants with nephropathy in Type 1 diabetes mellitus'. Diabetic Medicine, 27 :624-630. [DOI] [Details]
Martin, RJL,McKnight, AJ,Patterson, CC,Sadlier, DM,Maxwell, AP,Warren 3 UK GoKinD Study Grp; (2010) 'A rare haplotype of the vitamin D receptor gene is protective against diabetic nephropathy'. Nephrology Dialysis Transplantation, 25 :497-503. [DOI] [Details]
Currie, D,McKnight, AJ,Patterson, CC,Sadlier, DM,Maxwell, AP,UK Warren 3 GoKinD Study Grp; (2010) 'Investigation of ACE, ACE2 and AGTR1 genes for association with nephropathy in Type 1 diabetes mellitus'. Diabetic Medicine, 27 :1188-1194. [DOI] [Details]
McKnight, AJ,Patterson, CC,Sandholm, N,Kilner, J,Buckham, TA,Parkkonen, M,Forsblom, C,Sadlier, DM,Groop, PH,Maxwell, AP,Warren 3 UK Gokind Study Grp; (2010) 'Genetic Polymorphisms in Nitric Oxide Synthase 3 Gene and Implications for Kidney Disease: A Meta-Analysis'. American Journal of Nephrology, 32 :476-481. [DOI] [Details]
Devitt, E,Lawless, MW,Sadlier, D,Browne, JA,Walsh, C,Crowe, J; (2010) 'Early viral and peripheral blood mononuclear cell responses to pegylated interferon and ribavirin treatment: the first 24 h'. European Journal of Gastroenterology and Hepatology, 22 :1211-1220. [DOI] [Details]
Brennan EP, Ehrich M, Brazil DP, Crean JK, Murphy M, Sadlier DM, Martin F, Godson C, van den Boom D, Maxwell AP, Savage DA.; (2010) 'DNA methylation profiling in cell models of diabetic nephropathy'. Epigenetics : official journal of the DNA Methylation Society, 16 (5). [Details]
Brennan EP, Ehrich M, Brazil DP, Crean JK, Murphy M, Sadlier DM, Martin F,Godson C, McKnight AJ, van den Boom D, Maxwell AP, Savage DA. ; (2009) 'Comparative analysis of DNA methylation profiles in peripheral blood leukocytes versus lymphoblastoid cell lines'. Epigenetics : official journal of the DNA Methylation Society, 1 (4). [Details]
McKnight, AJ,Woodman, AM,Parkkonen, M,Patterson, CC,Savage, DA,Forsblom, C,Pettigrew, KA,Sadlier, D,Groop, PH,Maxwell, AP,Warren 3 UK GoKinD Study Grp; (2009) 'Investigation of DNA polymorphisms in SMAD genes for genetic predisposition to diabetic nephropathy in patients with type 1 diabetes mellitus'. Diabetologia, 52 :844-849. [DOI] [Details]
McKnight, AJ,Maxwell, AP,Fogarty, DG,Sadlier, D,Savage, DA,Warren 3 UK GoKinD Study Grp; (2009) 'Genetic analysis of coronary artery disease single-nucleotide polymorphisms in diabetic nephropathy'. Nephrology Dialysis Transplantation, 24 :2473-2476. [DOI] [Details]
Egido J, Gallego-Delgado J, Connolly SB, Lázaro A, Sadlier D, Kieran NE, Sugrue DD, Doran P, Brady HR, Osende J, ; (2009) 'Transcriptome of hypertension-induced left ventricular hypertrophy and its regression by antihypertensive therapies'. Hypertension Research, 32 (5):347-357. [DOI] [Details]
Fitzgerald DJ, Doherty GA, Byrne SM, Austin SC, Scully GM, Sadlier DM, Neilan TG, Kay EW, Murray FE, ; (2009) 'Regulation of the apoptosis-inducing kinase DRAK2 by cyclooxygenase-2 in colorectal cancer'. Journal of Cancer, 101 (3):483-491. [DOI] [Details]
Godson C, Murphy M, Crean J, Brazil DP, Sadlier D, Martin F, ; (2008) 'Regulation and consequences of differential gene expression in diabetic kidney disease'. Biochemical Society Transactions, 36 (Pt 5):941-945. [DOI] [Details]
Currie, D,Maxwell, AP,Sadlier, D,McKnight, AJ,Warren 3 UK GoKinD Study Grp; (2008) 'Investigation of Adducin 2 (beta) DNA polymorphisms in genetic predisposition to diabetic nephropathy in Type 1 diabetes'. Diabetic Medicine, 25 :1001-1005. [DOI] [Details]
Keating, DTK,Malizia, AP,Sadlier, D,Hurson, C,Wood, AE,McCarthy, J,Nolke, L,Egan, JJ,Doran, PP; (2008) 'LUNG TISSUE STORAGE: OPTIMIZING CONDITIONS FOR FUTURE USE IN MOLECULAR RESEARCH'. Experimental Lung Research, 34 (NA):455-466. [DOI] [Details]
Savage, DA,Patterson, CC,Deloukas, P,Whittaker, P,McKnight, AJ,Morrison, J,Boulton, AJ,Demaine, AG,Marshall, SM,Millward, BA,Thomas, SM,Viberti, GC,Walker, JD,Sadlier, D,Maxwell, AP,Bain, SC; (2008) 'Genetic association analyses of non-synonymous single nucleotide polymorphisms in diabetic nephropathy'. Diabetologia, 51 :1998-2002. [DOI] [Details]
Hurson, CJ,Butler, JS,Keating, DT,Murray, DW,Sadlier, DM,O'Byrne, JM,Doran, PP; (2007) 'Gene expression analysis in human osteoblasts exposed to dexamethasone identifies altered developmental pathways as putative drivers of osteoporosis'. BMC Musculoskeletal Disorders, 8 . [DOI] [Details]
McKnight, AJ,Savage, DA,Patterson, CC,Sadlier, D,Maxwell, AP; (2007) 'Resequencing of genes for transforming growth factor beta 1 (TGFB1) type 1 and 2 receptors (TGFBR1, TGFBR2), and association analysis of variants with diabetic nephropathy'. Gene, 8 . [DOI] [Details]
Butler, J. S.Butler, J. S.,Hurson, C.Hurson, C.,Murray, D.Murray, D.,Sadlier, D.Sadlier, D.,O'Byrne, J. M.O'Byrne, J. M.,Doran, P. P.Doran, P. P.; (2006) 'Altered developmental pathways as novel drivers of osteoporosis in primary human osteoblasts'. Osteoporosis InternationalOsteoporosis InternationalOsteoporosis International, 17 . Available Online [Details]
Keating, DT; Sadlier, DM; Patricelli, A; Smith, SM; Walls, D; Egan, JJ; Doran, PP; ; (2006) 'Microarray identifies ADAM family members as key responders to TGF-beta 1 in alveolar epithelial cells'. Respiratory Research, 7 (NA). [Details]
Keating DT, Sadlier D, Linehan R, Patricelli A, Smith S, Walls D, Egan JJ, Doran P. ; (2006) 'Microarray gene profiling identifies ADAM family members as key mediators of pulmonary fibrosis'. Respiratory Research, 7 :114. [Details]
Sadlier, DM,Ouyang, X,McMahon, B,Mu, W,Ohashi, R,Rodgers, K,Murray, D,Nakagawa, T,Godson, C,Doran, P,Brady, HR,Johnson, RJ; (2005) 'Microarray and bioinformatic detection of novel and established genes expressed in experimental anti-Thy1 nephritis'. Kidney International, 68 :2542-2561. [Details]
Rodgers, K; McMahon, B; Mitchell, D; Sadlier, D; Godson, C; ; (2005) 'Lipoxin A(4) modifies platelet-derived growth factor-induced profibrotic gene expression in human renal mesangial cells'. American Journal of Pathology, 167 (3):683-694. [Details]
Yasuda, Y; Schmid, H; Boucherot, A; Eichinger, F; Brunner, B; Sadlier, DM; Henger, A; Nitsche, A; Bleich, M; Cohen, CD; Doran, P; Brady, HR; Groene, HJ; Schloendorff, D; Nelson, PJ; Kretzler, M; ; (2005) 'Genome-wide transcriptomic analysis identifies gene expression signature of NF-kappa B pathway activation in progressive human diabetic nephropathy'. Nephrology Dialysis Transplantation, 20 (NA):371-371. [Details]
Dolan, V; Murphy, M; Sadlier, D; Lappin, D; Doran, P; Godson, C; Martin, F; O'Meara, Y; Schmid, H; Henger, A; Kretzler, M; Droguett, A; Mezzano, S; Brady, HR; ; (2005) 'Expression of gremlin, a bone morphogenetic protein antagonist, in human diabetic nephropathy'. American Journal of Kidney Diseases, 45 (6):1034-1039. [Details]
Sadlier, DM,Connolly, SB,Kieran, NE,Roxburgh, S,Brazil, DP,Kairaitis, L,Wang, Y,Harris, DCH,Doran, P,Brady, HR; (2004) 'Sequential extracellular matrix-focused and baited-global cluster analysis of serial transcriptomic profiles identifies candidate modulators of renal tubulointerstitial fibrosis in murine adriamycin-induced nephropathy'. Journal of Biological Chemistry, 279 :29670-29680. [DOI] [Details]
Keating, DT; Sadlier, D; Hurson, C; Doran, P; Egan, JJ; ; (2004) 'Oligonucleotide microarray analysis reveals coordinated expression of extracellular matrix associated genes in pulmonary fibrosis in vitro'. Thorax, 59 (1):42-42. [Details]
Sadlier, DM; Brazil, D; Doran, P; Brady, HR; ; (2003) 'Microarray and bioinformatic analysis identified common patterns of matrix gene expression in glomerular injury dependent and independent models of tubulo-interstitial fibrosis in vivo'. Journal of the American Society of Nephrology : JASN, 14 (NA):366-366. [Details]
Sadlier, DM; Frawley, A; Doran, P; Brady, HR; ; (2003) 'Comparison of bioinformatic techniques for analysis of microarray generated datasets reveals algorithm dependent conclusions regarding quantitative gene expression'. Journal of the American Society of Nephrology : JASN, 14 (NA):23-23. [Details]
Connolly, SB; Sadlier, D; Kieran, NE; Doran, P; Brady, HR; ; (2003) 'Transcriptome profiling and the pathogenesis of diabetic complications'. Journal of the American Society of Nephrology : JASN, 14 (NA):279-283. [Details]
Friel S, Hope A, Kelleher C, Comer S, Sadlier D. ; (2002) 'Impact evaluation of an oral health intervention amongst primary school children in Ireland'. Health Promot Int, 17 (2):119-126. [Details]
 

Conference Publications

Rooney B, Gaffney, A., Godson, C., Sadlier, D and Crean, JK.; (2010) CTGF/CCN2 activates canonical Wnt signaling in mesangial cells through LRP6; implications for the pathogenesis of diabetic nephropathy American Society of Nephrology [Details]
Godson C, Murphy M, Crean J, Brazil DP, Sadlier D, Martin F, ; (2008) Biochemical Society transactions Regulation and consequences of differential gene expression in diabetic kidney disease , pp.941-945 [DOI] [Details]
Lawlor, G., Murray, D, Moss, A., Leyden, J., Sadlier, D., O' Keane, C., Mulligan, AM., Arumuguma, M., Doyle, E., McEntee, G., MacMathuna, P. Doran, P.; (2006) Gastrointestinal Epithelial Cancers ' A Common Gene Expression Profile? The Irish Association for Cancer Research Annual Meeting [Details]
Keating, D.T., Sadlier, D., Linehan, R., Patricelli, A., Smith, S.M., Walls , D., Doran, P. Egan, J.J.; (2005) Microarrays reveal co-ordinated expression of ADAMs family of genes in an in vitro model of pulmonary fibrosis European respiratory society [Details]
Keating, D.T., Sadlier, D.M., Patricelli, A., Smith, S.M., Walls, D., Egan, J.J Doran, P.P.; (2005) Growth factor expression in pulmonary fibrosis; a genome wide view American Thoracic Society [Details]
Keating, D.T., Sadlier, D.M., Patricelli, A., Smith, S.M., Walls, D., Egan, J.J Doran, P.P.; (2005) Computational transcriptome annotation; A powerful strategy in respiratory research American Thoracic Society [Details]
Keating, D.T., Sadlier, D.M., Patricelli, A., Smith, S.M., Walls, D., Egan, J.J Doran, P.P.; (2005) Analysis of oligonucleotide microarray reveals coordinated expression of extracellular matrix associated genes in an in vitro model of pulmonary fibrosis American Thoracic Society [Details]
Connolly, SB,Sadlier, D,Kieran, NE,Doran, P,Brady, HR (2003) JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY Transcriptome profiling and the pathogenesis of diabetic complications , pp.279-283 [DOI] [Details]
                                                                                         

Research

 

Research Projects

Sponsor : University College Dublin Foundation Ltd.
Title : Gremlin in renal fibrosis
Start Date / End Date : 01-SEP-09 / 30-AUG-10
 

Current Postgraduate Students

Caitriona Mc Evoy, Doctor of Philosophy (PhD)   -   Thesis Supervisor

Teaching

 

Modules Coordinated

201500   MEDN40050     Medicine & Therapeutics: Audit & Clinical Research
201500   MEDN40100     Medicine & Therapeutics: Medicine II
201500   MDCS41390     Medicine Clinical Science: Independent Prof Practice