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Edward McKone

Associate Professor

School of Medicine
St. Vincent's University Hospital
Elm Park
Dublin 4

Tel: 353 1 213611
Email: e.mckone@svuh.ie

Biography

2002-2004

Acting Instructor, Division of Pulmonary and Critical Care Medicine, University of Washington, Seattle.

 

2004-2006

Assistant Professor, Division of Pulmonary and Critical Care Medicine, University of Washington, Seattle.

 

2006 to 2010

Affiliate Assistant Professor, Division of Pulmonary and Critical Care Medicine, University of Washington, Seattle.

 

2006-2016

Clinical Associate Professor, University College Dublin, Ireland.

Professional

 

Associations

Association: European Cystic Fibrosis Patient Registry, Function/Role: Director
Association: American Thoracic Society, Function/Role: Member
Association: American College of Chest Physicians, Function/Role: Fellow
Association: Irish Thoracic Society, Function/Role: Ex President
Association: European Cystic Fibrosis Society, Function/Role: Board Member
     

Conference Contributions

Keating, D., Glynn, S., Britton, D., Crowe, M., Gallagher, C., Drudy, D., Fanning, S., McKone, E. and Gallagher, C; (2007) Epidemiology of infection in an adult cystic fibrosis unit. [Oral Presentation], Irish Society for Cystic Fibrosis Annual Scientific Meeting, Killarney, Co. Kerry , 02-FEB-07.
 

Employment

Employer: University of Washington School of Medicine, Seattle, WA
Position: Affiliate Assistant Professor of Medicine
Employer: University of Washignton School of Medicine, Seattle, WA
Position: Assistant Professor of Medicine

Education

Year 2007 Institution:
Qualification: MB, BCh, BAO Subject:
Year 1993 Institution: Trinity College Dublin
Qualification: MB, BCh, BAO Subject: Medicine
Year 2007 Institution:
Qualification: MRCPI Subject:
Year 2005 Institution: Univerisity of Washington
Qualification: M.Sc. Subject: Genetic Epidemiology
Year 2002 Institution: University College Dublin
Qualification: MD Subject: Exercise Physiology
Year 1996 Institution: RCPI
Qualification: MRCPI Subject: Medicine
     

Journals Edited

Human Molecular Genetics: Reviewer.
Pediatric Pulmonology: Reviewer.
Gene: Reviewer.
Physiological Genomics: Reviewer.
Journal Of Cystic Fibrosis: Reviewer.
Family Practice: Reviewer.
Journal Of Applied Physics: Reviewer.
The Lancet Respiratory Medicine: Reviewer.
Clinical Genetics: Reviewer.
European Respiratory Journal: Reviewer.
Thorax: Reviewer.
Chest: Reviewer.
American Journal Of Respiratory And Critical Care Medicine: Reviewer.
Lancet: Reviewer.
 

Publications

 

Book Chapters

McKone, EF; Marshall, BC (2014) 'Using registries to improve cystic fibrosis care' In: Mall, MA; Elborn, JS (eds). Cystic Fibrosis, European Respiratory Monograph. Wakefield, UK: ERS. [Details]
 

Peer Reviewed Journals

Kilcoyne A, Lavelle LP;McCarthy CJ;McEvoy SH;Fleming H;Gallagher A;Loeve M;Tiddens H;McKone E;Gallagher CC;Dodd JD (2016) 'Chest CT abnormalities and quality of life: relationship in adult cystic fibrosis'. Annals of Translational Medicine, 4 (5). [DOI] [Details]
Hisert, K. B., Schoenfelt, K. Q., Cooke, G., Grogan, B., Launspach, J. L., Gallagher, C. G., Donnelly, S. C., Welsh, M. J., Singh, P. K., McKone, E. F., Becker, L. (2016) 'Ivacaftor-Induced Proteomic Changes Suggest Monocyte Defects May Contribute to the Pathogenesis of Cystic Fibrosis'. American Journal of Respiratory Cell and Molecular Biology, 54 (4):594-597. Available Online [DOI] [Details]
Ierodiakonou D, Zanobetti A;Coull BA;Melly S;Postma DS;Boezen HM;Vonk JM;Williams PV;Shapiro GG;McKone EF;Hallstrand TS;Koenig JQ;Schildcrout JS;Lumley T;Fuhlbrigge AN;Koutrakis P;Schwartz J;Weiss ST;Gold DR; (2015) 'Ambient air pollution, lung function, and airway responsiveness in asthmatic children'. Journal of Allergy and Clinical Immunology, . [DOI] [Details]
Sawicki GS, McKone EF;Pasta DJ;Millar SJ;Wagener JS;Johnson CA;Konstan MW (2015) 'Sustained Benefit from Ivacaftor Demonstrated by Combining Clinical Trial and Cystic Fibrosis Patient Registry Data'. American Journal of Respiratory and Critical Care Medicine, 192 (7):836-842. [DOI] [Details]
McKone EF, Velentgas P;Swenson AJ;Goss CH (2015) 'Association of sweat chloride concentration at time of diagnosis and CFTR genotype with mortality and cystic fibrosis phenotype'. Journal of Cystic Fibrosis, 14 (5):580-586. [DOI] [Details]
Wainwright CE, Elborn JS;Ramsey BW;Marigowda G;Huang X;Cipolli M;Colombo C;Davies JC;De Boeck K;Flume PA;Konstan MW;McColley SA;McCoy K;McKone EF;Munck A;Ratjen F;Rowe SM;Waltz D;Boyle MP; ; (2015) 'Lumacaftor-Ivacaftor in Patients with Cystic Fibrosis Homozygous for Phe508del CFTR'. New England Journal of Medicine, 373 (3):220-231. [DOI] [Details]
Carter S, Kelly S;Caples E;Grogan B;Doyle J;Gallagher CG;McKone EF (2015) 'Ivacaftor as salvage therapy in a patient with cystic fibrosis genotype F508del/R117H/IVS8-5T'. Journal of Cystic Fibrosis, 14 (4):1-5. [DOI] [Details]
Keating D, Crowe MJ;Kennedy B;Salmon A;Britton D;Gallagher CG;McKone EF;Schaffer K (2014) 'Molecular detection of an atypical, highly resistant, clonal Pseudomonas aeruginosa isolate in cystic fibrosis patients'. Journal of Cystic Fibrosis, 12 (2):141-146. [DOI] [Details]
McKone EF, Borowitz D;Drevinek P;Griese M;Konstan MW;Wainwright C;Ratjen F;Sermet-Gaudelus I;Plant B;Munck A;Jiang Y;Gilmartin G;Davies JC; (2014) 'Long-term safety and efficacy of ivacaftor in patients with cystic fibrosis who have the Gly551Asp-CFTR mutation: a phase 3, open-label extension study (PERSIST)'. The Lancet Respiratory Medicine, 2 (11):902-910. [DOI] [Details]
Smyth RJ, Fabre A;Dodd JD;Bartosik W;Gallagher CG;McKone EF (2014) 'Pulmonary blastoma: a case report and review of the literature'. BMC Research Notes, 7 . [DOI] [Details]
Adamali H, Armstrong ME, McLaughlin AM, Cooke G, McKone E, Costello CM, Gallagher CG, Leng L, Baugh JA, Fingerle-Rowson G, Bucala RJ, McLoughlin P, Donnelly SC (2012) 'Macrophage migration inhibitory factor enzymatic activity, lung inflammation, and cystic fibrosis'. American Journal of Respiratory and Critical Care Medic, 186 (2):162-169. [DOI] [Details]
McEvoy S, Lavelle L;Kilcoyne A;McCarthy C;deJong PA;Loeve M;Tiddens HA;McKone E;Gallagher CG;Dodd JD (2012) 'High-resolution CT of nontuberculous mycobacterium infection in adult CF patients: diagnostic accuracy'. European Radiology, 22 (12):2736-2742. [DOI] [Details]
Jackson AD, Daly L, Jackson AL, Kelleher C, Marshall BC, Quinton HB, Fletcher G, Harrington M, Zhou S, McKone EF, Gallagher C, Foley L, Fitzpatrick P.; (2011) 'Validation and use of a parametric model for projecting cystic fibrosis survivorship beyond observed data: a birth cohort analysis'. Thorax, 66 (8):674-679. [Details]
Ramsey BW, Davies J;McElvaney NG;Tullis E;Bell SC;D¿¿ev¿¿nek P;Griese M;McKone EF;Wainwright CE;Konstan MW;Moss R;Ratjen F;Sermet-Gaudelus I;Rowe SM;Dong Q;Rodriguez S;Yen K;Ordo¿¿ez C;Elborn JS; (2011) 'A CFTR potentiator in patients with cystic fibrosis and the G551D mutation'. The New England journal of medicine, 365 (18):1663-1672. [DOI] [Details]
Darrah, R,McKone, E,O'Connor, C,Rodgers, C,Genatossio, A,McNamara, S,Gibson, R,Elborn, JS,Ennis, M,Gallagher, CG,Kalsheker, N,Aitken, M,Wiese, D,Dunn, J,Smith, P,Pace, R,Londono, D,Goddard, KAB,Knowles, MR,Drumm, ML; (2010) 'EDNRA variants associate with smooth muscle mRNA levels, cell proliferation rates, and cystic fibrosis pulmonary disease severity'. Physiological genomics, 41 :71-77. [DOI] [Details]
Siklosi K, Gallagher CG, McKone EF; (2010) 'Development, validation, and implementation of a questionnaire assessing disease knowledge and understanding in adult cystic fibrosis patients in Ireland'. Journal of Cystic Fibrosis, epub . [Details]
Dodd JD, McDermott S, Barry SC, Judge EE, Collins S, de Jong PA, Tiddens HA, McKone EF, Gallagher CC, ; (2009) 'Tracheomalacia in adults with cystic fibrosis: determination of prevalence and severity with dynamic cine CT'. Radiology, 252 (2):577-586. [DOI] [Details]
Goss CH, McKone EF, Mathews D, Kerr D, Wanger JS, Millard SP; the Cystic Fibrosis Therapeutics Development Network. ; (2007) 'Experience using centralized spirometry in the phase 2 randomized, placebo-controlled, double-blind trial of denufosol in patients with mild to moderate cystic fibrosis'. J Cyst Fibrosis, . [Details]
McKone EF, Goss CH, Aitken ML. ; (2006) 'CFTR genotype as a predictor of prognosis in cystic fibrosis'. Chest, 130 (5):1441-1447. [Details]
McKone EF, Shao J, Margoolias, D, , Keener CL, Farin FM, Tonelli MR, Pare, P.D.,, Aitken, M.L., Sandford, A.J., Kavanagh, T.J. ; (2006) 'Variants in the Glutamate-Cysteine-Ligase Gene are Associated with Cystic Fibrosis Lung Disease'. American Journal of Respiratory and Critical Care Medic, 174 (4):415. [Details]
McKone, E. F.,Barry, S. C.,Fitzgerald, M. X.,Gallagher, C. G.; (2005) 'Role of arterial hypoxemia and pulmonary mechanics in exercise limitation in adults with cystic fibrosis'. J Appl Physiol, 99 (3):1012-8. [Details]
McKone EF, Emerson SS, Edwards KL, Aitken ML.; (2003) 'Effect of genotype on phenotype and mortality in cystic fibrosis: a retrospective cohort study'. Lancet, 17 (361):1671-1676. [Details]
Thin, AG,Linnane, SJ,McKone, EF,Freaney, R,FitzGerald, MX,Gallagher, CG,McLoughlin, P; (2002) 'Use of the gas exchange threshold to noninvasively determine the lactate threshold in patients with cystic fibrosis'. Chest, 121 :1761-1770. [Details]
McKone, E.F., Barry, S.C., FitzGerald, M.X., and Gallagher, C.G.; (1999) 'Reproducibility of maximal exercise ergometer testing in patients with cystic fibrosis'. Chest, 116 (2):363-368. [Details]
 

Conference Publications

Hisert, K.B; Shoenfelt, K.Q; Cooke, G; Grogan, B; Launspach, J.L; Gallagher, C.G.; Donnelly, S.C; Welsh, M.J; Singh, P; McKone, E.F; Becker, L; (2014) Effects of CFTR dysfunction on myeloid cell protein expression The 28th Annual North American Cystic Fibrosis Conference Georgia, USA, , pp.269-270 Available Online [Details]
Hisert, K.B; Jorth, P; Cooke, G; Garudathri, J; Wu, X; Pope, C; Grogan, B; Gallagher, C.G; Donnelly, S.C; Hoffman, L; Bruce, J; Welsh, M.J; McKone, E.F; Singh, P; (2014) Ivacaftor treatment of patients with the CFTR G551D mutation produces both acute and long term changes in the infecting Pseudomonas aeruginosa populations The 28th Annual North American Cystic Fibrosis Conference Georgia, USA, , pp.348 Available Online [Details]
Hisert, K; Schoenfelt, KQ; Cooke, G; Grogan, B; Launspach, J; Gallagher, C; Donnelly, SC; Welsh, J; Singh, P; McKone, E; Becker, L; (2013) Studying peripheral blood monocytes from people with G551D mutations before and after ivacaftor treatment to investigate CFTR'S effect on myeloid cell function The 27th Annual North American Cystic Fibrosis Conference America, , pp.232-232 Available Online [Details]

Published Reports

Zolin, A; van Rens, J; Fox, A; Iansa, P; Preftitsi, A; Pypops, U; Gulmans, V; Jung, A; Mehta, A; Viviani, L; Vebert Olesen, H; McKone, E (2010) ECFS Patient Registry: Annual Data Report 2010. ECFS, Karup, Denmark. [Details]
                                                                                       

Research

Research Interests

Cystic Fibrosis/Bronchiectasis
Genetic Epidemiology
Clinical Epidemiology
Clinical Trials
 
UCD Medicine Research Individual Investigator 

Research Projects

Sponsor : Irish Thoracic Society (ITS)
Title : Understanding Exacerbations of Cystic Fibrosis
Start Date / End Date : 13-JUL-15 / 09-JUL-17
Sponsor : Cystic Fibrosis Association of Ireland (CFAI)
Title : Genetic Modifiers of the Cystic Fibrosis Phenotype
Start Date / End Date : 01-JUL-10 / 30-JUN-12
Sponsor : St. Vincent's University Hospital
Title : Cystic Fibrosis Clinical Research
Start Date / End Date : 01-JUL-12 / 31-OCT-16
Sponsor : Vertex Pharmaceuticals Inc.
Title : Acute Effects of Kalydeco in People with CF and the G551D Mutation
Start Date / End Date : 01-MAR-13 / 01-APR-13
 

Current Postgraduate Students

Suzanne Carter, Medicine (MD)   -   Thesis Supervisor

Collaborators

Internal Collaborators

Judith Coppinger, Conway Institute, UCD.
Gordon Cooke, Conway Institute, UCD 

External Collaborators

Prof Pradeep Singh, University of Washington, Seattle, USA
Prof Christopher Goss, University of Washington, Seattle, USA
Prof David Stoltz, University of Iowa, USA
Prof Michael Welsh, University of Iowa, USA
Prof Lev Becker, University of Chicago, USA