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Researchers at UCD

Emma Rebecca Dorris

Postdoc Research Fellow Lvl Ii

School Of Medicine
Conway Institute
Belfield
Dublin 4

Tel:
Email: emma.dorris@ucd.ie

Biography

2013- Present  Post-Doc Research Fellow, School of Medicine and Medical Sciences ,Conway Institute, UCD 
2008-2012 Ph.D. in Molecular Medicine, School of Medicine, Institute of Molecular Medicine, Trinity College Dublin
2009-2010  Postgraduate Diploma in Statistics, School of Computer Science & Statistics, Trinity College Dublin

 

Publications

     

Peer Reviewed Journals

Dorris, E; O¿Neill, A; Hanrahan, K; Treacy, A; and Watson, RW (2017) 'MARCKS promotes invasion and is associated with biochemical recurrence in prostate cancer'. Oncotarget, . [Details]
Emma R Dorris, Gordon Blackshields, Gary Sommerville, Mohsen Alhashemi, Andrew Dias, Victoria McEneaney, Paul Smyth, John J O'Leary, Orla Sheils (2016) 'Pluripotency markers are differentially induced by MEK inhibition in thyroid and melanoma BRAFV600E cell lines'. Cancer Biology and Therapy, . [Details]
Stephen H.-F. Macdonald, Elliott Woodward, Michelle M. Coleman, Emma R. Dorris, Parthiban Nadarajan, Wui-Mei Chew, Anne-Marie McLaughlin, and Joseph Keane (2012) 'Networked T Cell Death following Macrophage Infection by Mycobacterium tuberculosis'. PLoS ONE, . [Details]
Emma R. Dorris, Paul Smyth, John J. O¿Leary and Orla Sheils (2012) 'MIR141 expression differentiates Hashimoto thyroiditis from PTC and benign thyrocytes in Irish archival thyroid tissues'. Frontiers in endocrinology, . [Details]
Emma R. Cantwell-Dorris, John J. O'Leary and Orla M. Sheils (2011) 'BRAFV600E: Implications for Carcinogenesis and Molecular Therapy'. Molecular Cancer Therapeutics, . [Details]
Declan Madsen, Emma R. Cantwell, Timothy O'Brien, Patricia A. Johnson and Bernard P. Mahon (2009) 'Adeno-associated virus serotype 2 induces cell-mediated immune responses directed against multiple epitopes of the capsid protein VP1'. Journal of General Virology, . [Details]
                                                                                                                     

Research

Research Interests

I am currently working on a HRB-Arthritis Ireland project to characterise the novel rheumatoid arthritis susceptibility gene C5orf30. I work as part of the UCD Centre for Arthritis Research to develop better treatment strategies for rheumatic disease. We apply a translational approach to research, using genetic analysis of patient cohorts to identify novel regulators of disease, through characterisation of these novel molecules and elucidation of their biological function in both health and disease.  With a particular focus on rheumatoid arthritis, we aim to characterise the molecular pathogenesis of the disease such that we may develop better treatment strategies for patients.

My previous research focused on understanding the central signalling pathways and transcription factors underlying the androgen-resistant phenotype of prostate cancer with the aim of developing a more appropriate therapeutic targeting approach. During this time I demonstrated that the protein MARCKS promotes migration and invasion and is associated with biochemical recurrence in prostate cancer.
 

I hold a PhD in Molecular Medicine from the University of Dublin, Trinity College. The focus during my PhD was in transcriptional profiling to identify mechanisms of resistance to molecularly targeted therapeutics of cancer. I had a particular focus on small non-coding RNAs and next generation sequencing and have worked in a lab placement at the European Next Generation Sequencing Headquarters of Applied Biosciences/Life Technologies.