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Eoin Cummins

Lecturer/Assistant Professor

Conway Institute
F114
SBI Building
UCD School of Medicine
Belfield
Dublin 4

Tel: 353 1 716 6317
Email: eoin.cummins@ucd.ie

Biography

Aug 2013- present
Lecturer / Assistant Professor in Physiology, School of Medicine, UCD, Dublin, Ireland


Mar 2012-May 2012
Travel Fellowship (funded by SFI), Northwestern University, USA

 

Aug 2011-2013
Research Fellow, UCD Conway Institute

 

2008- Aug 2011
Senior post-doctoral researcher; UCD Conway Institute

2006-2008
Post-doctoral researcher; UCD Conway Institute

UCD Medicine Research Individual Investigators

My research team is based in the Conway Institute UCD. The focus of our research is how different levels of the physiological gases oxygen and carbon dioxide contribute to cell signaling, particularly in the context of inflammation.

Professional

Honours and Awards

Year: 2002.
Title: Astra Zeneca award for highest grade in Pharmacology Degree
Year: 2004.
Title: Lord Edward Fitzgerald Memorial Fund
Year: 2005.
Title: Oncology Travel Award
Year: 2012.
Title: Short Term Travel Fellowship
Year: 2006.
Title: NIAID Keystone Symposia Scholarship Award
       

Conference Contributions

*; (2006) Keystone Symposia, NF-kB: 20 Years on the Road from Biochemistry to Pathology. [Poster Presentation], Keystone Symposia, NF-kB: 20 Years on the Road from Biochemistry to Pathology, Banff, Canada , 23-MAR-06 - 28-MAR-06.
*; (2006) Keystone Symposia, Hypoxia and Development, Physiology and Disease. [Poster Presentation], Keystone Symposia, Hypoxia and Development, Physiology and Disease, Breckonridge, USA , 16-JAN-06 - 21-JAN-06.
Cummins, E (2015) Oxygen and carbon dioxide cross-talk in the HIF pathway. [Oral Presentation], Keystone Symposia: Hypoxia: From basic mechanisms to therapeutics, Dublin , 12-MAY-15 - 17-MAY-15.
   

Education

Year 2007 Institution: University College Dublin
Qualification: PhD Subject:
     

Journals Edited

Journal Of Immunology: Reviewer.
Scientific Reports: Reviewer.
Febs Open Bio: Reviewer.
Journal Of Molecular Medicine: Reviewer.
Mucosal Immunology: Reviewer.
European Journal Of Immunology: Reviewer.
British Journal Of Cancer: Reviewer.
Plos One: Reviewer.
Expert Opinion On Investigational Drugs: Reviewer.
Gut: Reviewer.
Pflugers Archiv European Journal Of Physiology: Reviewer.
Gastroenterology: Reviewer.
 

Publications

     

Peer Reviewed Journals

Fitzpatrick SF, F¿¿bi¿¿n Z;Schaible B;Lenihan CR;Schwarzl T;Rodriguez J;Zheng X;Li Z;Tambuwala MM;Higgins DG;O'Meara Y;Slattery C;Manresa MC;Fraisl P;Bruning U;Baes M;Carmeliet P;Doherty G;von Kriegsheim A;Cummins EP;Taylor CT (2016) 'Prolyl hydroxylase-1 regulates hepatocyte apoptosis in an NF-¿¿B-dependent manner'. Biochemical and Biophysical Research Communications, . [DOI] [Details]
Scholz CC, Rodriguez J;Pickel C;Burr S;Fabrizio JA;Nolan KA;Spielmann P;Cavadas MA;Crifo B;Halligan DN;Nathan JA;Peet DJ;Wenger RH;Von Kriegsheim A;Cummins EP;Taylor CT (2016) 'FIH Regulates Cellular Metabolism through Hydroxylation of the Deubiquitinase OTUB1'. PLoS Biology, 14 (1). [DOI] [Details]
Cummins EP, Keogh CE;Crean D;Taylor CT (2016) 'The role of HIF in immunity and inflammation'. Molecular Aspects of Medicine, 47-48 :24-34. [DOI] [Details]
Selfridge AC, Cavadas MA;Scholz CC;Campbell EL;Welch LC;Lecuona E;Colgan SP;Barrett KE;Sporn PH;Sznajder JI;Cummins EP;Taylor CT (2016) 'Hypercapnia Suppresses the HIF-dependent Adaptive Response to Hypoxia'. The Journal of biological chemistry, 291 (22):11800-11808. [DOI] [Details]
Beaton H, Andrews D;Parsons M;Murphy M;Gaffney A;Kavanagh D;McKay GJ;Maxwell AP;Taylor CT;Cummins EP;Godson C;Higgins DF;Murphy P;Crean J (2016) 'Wnt6 regulates epithelial cell differentiation and is dysregulated in renal fibrosis'. American journal of physiology. Renal physiology, . [DOI] [Details]
Crean D, Cummins EP, Bahar B, Mohan H, McMorrow JP, Murphy EP (2015) 'Adenosine Modulates NR4A Orphan Nuclear Receptors To Attenuate Hyperinflammatory Responses in Monocytic Cells'. Journal of Immunology, 195 (4):1436-1448. [DOI] [Details]
Tambuwala, MM; Manresa, MC; Cummins, EP; Aversa, V; Coulter, IS; Taylor, CT (2015) 'REST mediates resolution of HIF-dependent gene expression in prolonged hypoxia'. Journal of Controlled Release, 217 :221-227. [Details]
Cavadas MA, Mesnieres M;Crifo B;Manresa MC;Selfridge AC;Scholz CC;Cummins EP;Cheong A;Taylor CT (2015) 'REST mediates resolution of HIF-dependent gene expression in prolonged hypoxia'. Scientific Reports, 5 . [DOI] [Details]
Scholz CC, Cavadas MA, Tambuwala MM, Hams E, Rodríguez J, Kriegsheim AV, Cotter P, Bruning U, Fallon PG, Cheong A, Cummins EP, Taylor CT (2013) 'Regulation of IL-1β-induced NF-κB by hydroxylases links key hypoxic and inflammatory signaling pathways'. Proceedings of the National Academy of Sciences of the United States of America, . [DOI] Link to full text [Details]
Cummins, EP,Doherty, GA,Taylor, CT (2013) 'Hydroxylases as therapeutic targets in inflammatory bowel disease'. Laboratory Investigation, 93 :378-383. [DOI] [Details]
Cummins EP, Selfridge AC, Sporn PH, Sznajder JI, Taylor CT (2013) 'Carbon dioxide-sensing in organisms and its implications for human disease'. Cellular and Molecular Life Sciences, . [DOI] [Details]
McMorrow JP, Crean D, Gogarty M, Smyth A, Connolly M, Cummins E, Veale D, Fearon U, Tak PP, Fitzgerald O, Murphy EP (2013) 'Tumor necrosis factor inhibition modulates thrombospondin-1 expression in human inflammatory joint disease through altered NR4A2 activity'. Pathology, 183 (4):1243-1257. [DOI] [Details]
Tannahill GM, Curtis AM, Adamik J, Palsson-McDermott EM, McGettrick AF, Goel G, Frezza C, Bernard NJ, Kelly B, Foley NH, Zheng L, Gardet A, Tong Z, Jany SS, Corr SC, Haneklaus M, Caffrey BE, Pierce K, Walmsley S, Beasley FC, Cummins E, Nizet V, Whyte M, Taylor CT, Lin H, Masters SL, Gottlieb E, Kelly VP, Clish C, Auron PE, Xavier RJ, O'Neill LA (2013) 'Succinate is an inflammatory signal that induces IL-1β through HIF-1α'. Nature, 496 (7444):238-242. [DOI] [Details]
Cummins EP, Doherty GA, Taylor CT (2013) 'Hydroxylases as therapeutic targets in inflammatory bowel disease'. Laboratory Investigation, . [DOI] [Details]
Nguyen LK, Cavadas MA, Scholz CC, Fitzpatrick SF, Bruning U, Cummins EP, Tambuwala MM, Manresa MC, Kholodenko BN, Taylor CT, Cheong A (2013) 'A dynamic model of the hypoxia-inducible factor 1-alpha (HIF-1a) network'. Journal of Cell Science, . [DOI] Link to full text [Details]
Cummins EP (2012) 'HIF-2α - a mediator of stem cell altruism?'. Cell Research, 3 (6). [DOI] [Details]
Oliver KM, Lenihan CR, Bruning U, Cheong A, Laffey JG, McLoughlin P, Taylor CT, Cummins EP; (2012) 'Hypercapnia induces cleavage and nuclear localization of REL B giving insight into co2 sensing and signalling'. Journal of Biological Chemistry, . [DOI] Link to full text [Details]
Cahill E, Costello CM, Rowan SC, Harkin S, Howell K, Leonard MO, Southwood M, Cummins EP, Fitzpatrick SF, Taylor CT, Morrell NW, Martin F, McLoughlin P; (2012) 'Gremlin plays a key role in the pathogenesis of pulmonary hypertension'. Circulation, 125 (7):920-930. [DOI] Link to full text [Details]
Bruning U, Cerone L, Neufeld Z, Fitzpatrick SF, Cheong A, Scholz CC, Simpson DA, Leonard MO, Tambuwala MM, Cummins EP, Taylor CT; (2011) 'MicroRNA-155 Promotes Resolution of Hypoxia-Inducible Factor 1 alpha Activity during Prolonged Hypoxia'. Molecular and Cellular Biology, 31 :4087-4096. [DOI] [Details]
Taylor CT, Cummins EP; (2011) 'Regulation of gene expression by carbon dioxide'. The Journal of physiology, 589 (Pt 4):797-803. [DOI] Link to full text [Details]
Hams E, Saunders SP, Cummins EP, O'Connor A, Tambuwala MT, Gallagher WM, Byrne A, Campos-Torres A, Moynagh PM, Jobin C, Taylor CT, Fallon PG; (2011) 'The hydroxylase inhibitor dimethyloxallyl glycine attenuates endotoxic shock via alternative activation of macrophages and IL-10 production by B1 cells'. Shock, 36 (3):295-302. [Details]
Agbor TA, Cheong A, Comerford KM, Scholz CC, Bruning U, Clarke A, Cummins EP, Cagney G, Taylor CT; (2011) 'Small Ubiquitin-related Modifier (SUMO)-1 Promotes Glycolysis in Hypoxia'. Journal of Biological Chemistry, 286 :4718-4726. [DOI] [Details]
Fitzpatrick, SF,Tambuwala, MM,Bruning, U,Schaible, B,Scholz, CC,Byrne, A,O'Connor, A,Gallagher, WM,Lenihan, CR,Garvey, JF,Howell, K,Fallon, PG,Cummins, EP,Taylor, CT; (2011) 'An Intact Canonical NF-kappa B Pathway Is Required for Inflammatory Gene Expression in Response to Hypoxia'. Journal of Immunology, 186 :1091-1096. [DOI] [Details]
Coffey, R,Cummins, E,Bhreathnach, N,Flaherty, VO,Cormican, M; (2010) 'Development of a pathogen transport model for Irish catchments using SWAT'. Agricultural Water Management, 97 :101-111. [DOI] [Details]
Cummins EP, Oliver KM, Lenihan CR, Fitzpatrick SF, Bruning U, Scholz CC, Slattery C, Leonard MO, McLoughlin P, Taylor CT (2010) 'NF-κB links CO2 sensing to innate immunity and inflammation in mammalian cells'. Journal of Immunology, 185 (7):4439-4445. [DOI] Link to full text [Details]
Tambuwala MM, Cummins EP, Lenihan CR, Kiss J, Stauch M, Scholz CC, Fraisl P, Lasitschka F, Mollenhauer M, Saunders SP, Maxwell PH, Carmeliet P, Fallon PG, Schneider M, Taylor CT; (2010) 'Loss of prolyl hydroxylase-1 protects against colitis through reduced epithelial cell apoptosis and increased barrier function'. Gastroenterology, . Link to full text [Details]
Agbor TA, Cheong A, Comerford KM, Scholz CC, Bruning U, Clarke A, Cummins EP, Cagney G, Taylor CT; (2010) 'Small ubiquitin-related modifier (SUMO)-1 protein modification promotes glycolysis in Hypoxia'. Journal of Biological Chemistry, . [DOI] [Details]
Oliver, KM,Garvey, JF,Ng, CT,Veale, DJ,Fearon, U,Cummins, EP,Taylor, CT; (2009) 'Hypoxia Activates NF-kappa B-Dependent Gene Expression Through the Canonical Signaling Pathway'. Antioxidants and Redox Signaling, 11 :2057-2064. [DOI] [Details]
Taylor, C. T.,Cummins, E. P.; (2009) 'The role of NF-kappaB in hypoxia-induced gene expression'. Ann N Y Acad Sci, 1177 :178-84178. Available Online [Details]
Oliver, K. M.,Taylor, C. T.,Cummins, E. P.; (2009) 'Hypoxia. Regulation of NFkappaB signalling during inflammation: the role of hydroxylases'. Arthritis Res Ther, 11 (11):215215. Available Online [Details]
O'Hagan, KA,Cocchiglia, S,Zhdanov, AV,Tambawala, MM,Cummins, EP,Monfared, M,Agbor, TA,Garvey, JF,Papkovsky, DB,Taylor, CT,Allan, BB; (2009) 'PGC-1 alpha is coupled to HIF-1 alpha-dependent gene expression by increasing mitochondrial oxygen consumption in skeletal muscle cells'. Proceedings of the National Academy of Sciences of the United States of America, 106 :2188-2193. [DOI] [Details]
Cummins, EP,Seeballuck, F,Keely, SJ,Mangan, NE,Callanan, JJ,Fallon, PG,Taylor, CT; (2008) 'The hydroxylase inhibitor dimethyloxalylglycine is protective in a murine model of colitis'. Journal of Gastroenterology, 134 :156-165. [DOI] [Details]
Barry RE, Allan BB, Cummins EP, Kattla JJ, Giblin A, Scally N, Taylor CT, Brazil DP. ; (2007) 'Enhanced sensitivity of protein kinase B/Akt to insulin in hypoxia is independent of HIF1alpha and promotes cell viability'. European Journal of Cell Biology, 86 (7):393-403. [Details]
Cummins EP, Comerford KM, Scholz C, Bruning U, Taylor CT (2007) 'Hypoxic Regulation of NF-kappaB signaling'. Methods in Enzymology, 435 :479-492. [Details]
O'Reilly, SM; Leonard, MO; Kieran, N; Comerford, KM; Cummins, E; Pouliot, M; Lee, SB; Taylor, CT; ; (2006) 'Hypoxia induces epithelial amphiregulin gene expression in a CREB-dependent manner'. American Journal of Physiology - Cell Physiology, 290 (2):592-600. [Details]
Comerford, KM; Leonard, MO; Cummins, EP; Fitzgerald, KT; Beullens, M; Bollen, M; Taylor, CT; ; (2006) 'Regulation of protein phosphatase 1 gamma activity in hypoxia through increased interaction with NIPP1: Implications for cellular metabolism'. Journal of Cellular Physiology, 209 (1):211-218. [Details]
Cummins, EP; Berra, E; Comerford, KM; Ginouves, A; Fitzgerald, KT; Seeballuck, F; Godson, C; Nielsen, JE; Moynagh, P; Pouyssegur, J; Taylor, CT; ; (2006) 'Prolyl hydroxylase-1 negatively regulates I kappa B kinase-beta, giving insight into hypoxia-induced NF kappa B activity'. Proceedings of the National Academy of Sciences of the United States of America, 103 (48):18154-18159. [Details]
Cummins EP, Taylor CT; (2005) 'Hypoxia-responsive transcription factors'. Pflugers Archiv European Journal of Physiology, 450 (6):363-371. [DOI] [Details]
Comerford, KM, Cummins, EP & Taylor, CT; (2004) 'JNK activation contributes to HIF-1-dependent p-glycoprotein expression in hypoxia'. Cancer Research, 64 :9057-9061. [Details]
Comerford, KM; Cummins, EP; Taylor, CT; ; (2004) 'c-Jun NH2-terminal kinase activation contributes to hypoxia-inducible factor 1 alpha-dependent P-glycoprotein expression in hypoxia'. Cancer Research, 64 (24):9057-9061. [Details]

Other Journals

Comerford, K.M., Leonard, M.O., Cummins, E.P., Fitzgerald, K., Beullens, M., Bollen, M. Taylor C.T.; (2006) 'Regulation of progin phosphatase 1 activity in hypoxia through increased interaction with NIPP1: implications for cellular metaboliism' J.Cell Physiol . [Details]
Cummins, E.P. Taylor, C.T.; (2005) 'Hypoxia-responsive transcription factors' Eur. J. Physiol . [Details]

Conference Publications

Taylor, CT,Cummins, EP (2009) HYPOXIA AND CONSEQUENCES FROM MOLECULE TO MALADY The Role of NF-kappa B in Hypoxia-Induced Gene Expression , pp.178-184 [DOI] [Details]
   

Editorial

Cummins, EP (2012) HIF-2 alpha - a mediator of stem cell altruism?. Editorial [DOI] [Details]
                 

Abstract

Oliver, KM,Lenihan, CR,Bruning, U,Cheong, A,Laffey, JG,McLoughlin, P,Fitzpatrick, SF,Scholz, CC,Slattery, C,Leonard, MO,Taylor, CT,Cummins, EP (2012) Carbon dioxide (CO2) sensing at the axis of immunity and inflammation. Abstract [Details]
       

Reviews

Taylor, CT,Cummins, EP (2011) Regulation of gene expression by carbon dioxide. Reviews [DOI] [Details]
Oliver, KM,Taylor, CT,Cummins, EP (2009) Hypoxia Regulation of NF kappa B signalling during inflammation: the role of hydroxylases. Reviews [DOI] [Details]
Cummins, EP,Comerford, KM,Scholz, C,Bruning, U,Taylor, CT (2007) Hypoxic regulation of NF-kappa B signaling. Reviews [DOI] [Details]
Cummins, EP,Taylor, CT (2005) Hypoxia-responsive transcription factors. Reviews [DOI] [Details]
                                                     

Research

Research Interests

Hypoxia (low oxygen levels) and hypercapnia (high carbon dioxide levels) are a feature of several pathological conditions including lung disease. Our work has demonstrated that manipulation of environmental oxygen and carbon dioxide levels can significantly impact upon inflammatory signaling. Current projects are directed towards understanding the mechanisms underpinning the cellular sensitivity to carbon dioxide and cross talk between oxygen and carbon dioxide signaling pathways. 

Research Projects

Sponsor : University College Dublin (UCD)
Title : Mechanisms of CO2-dependent regulation of NFkB signalling
Start Date / End Date : 01-APR-16 / 30-SEP-17
Sponsor : University College Dublin (UCD)
Title : Examination of the effect of DMOG in a murine model of colitis with mice that lack HIF specifically in the gut
Start Date / End Date : 26-MAY-08 / 01-DEC-09
Sponsor : University College Dublin (UCD)
Title : The influence of carbon dioxide on inflammatory signaling
Start Date / End Date : 01-MAY-13 / 31-OCT-14
Sponsor : University College Dublin (UCD)
Title : School funded research account
Start Date / End Date : 24-SEP-14 / 23-AUG-18
Sponsor : University College Dublin (UCD)
Title : The influence of carbon dioxide on (i) nuclear receptor and (ii) cancer signalling
Start Date / End Date : 01-APR-15 / 30-SEP-16
 

Current Postgraduate Students

Ciara Keogh, Doctor of Philosophy (PhD)   -   Thesis Supervisor
Bianca Crifo, Doctor of Philosophy (PhD)   -   Secondary Supervisor

Teaching

Teaching Philosophy

My teaching philosophy centres on promoting student engagement and understanding of key physiological concepts. With strong fundamental foundations students can then effectively build additional layers of complexity and integrate related concepts and systems.

Modules Coordinated

201500   PHYS30090     Physiology: Digestion and Excretion
201500   PHYS30240     Physiology: GI and Renal Physiology
       

Collaborators

Internal Collaborators

Prof. Cormac Taylor, UCD
Dr. Silke Ryan, UCD
Dr. Daniel Crean, UCD
 

External Collaborators

Prof. Jacob Sznader, Northwestern University
Prof. Peter Sporn, Northwestern University
Prof. Sean Colgan, University of Colorado, Denver
Dr. Alex von Kriegsheim, Edinburgh University
Dr. Carsten Scholz, Zurich University