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Researchers at UCD

researcher

Fionnuala Ní Aínle

Clinical Associate Fellow, Associate Professor, Co-Director, Sphere Research Group

School of Medicine
UCD Conway Institute,
UCD
Belfield
Dublin 4

Tel: 01-8034445
Email: fniainle@mater.ie

Biography

My research interests explore the role of blood coagulation in the aetiology, management and therapy of clinical disorders. I co-direct the UCD Conway research group SPHERE with Dr Patricia Maguire (Principal Investigator and Fellow at the UCD Conway Institute and an Associate Professor in Biochemistry in the School of Biomolecular & Biomedical Science, UCD).  This novel translational research group was launched in September 2015 at an international thrombosis conference (www.vtedublin2015.com). The launch of SPHERE was welcomed by the Irish Minister for Health Dr Leo Varadkar in his address to conference delegates. SPHERE brings together clinical and academic collaborators nationally and internationally, harnessing unique tools to diagnose and understand a host of inflammatory-based diseases, including thrombotic disorders.

The acronym SPHERE describes the state-of the art translational interests of the group, which will focus upon "Systemic inflammatory disorders: role of blood Particles, Haemostatic factors and ExtRacEllular vesicles".

UCD Medicine Research Individual Investigator 

Professional

 

Associations

Association: British Society of Haematology Obstetrics Group, Function/Role: Member
Association: International Society of Haemostasis and Thrombosis, Function/Role: Member
Association: American Society of Hematology, Function/Role: Member

Patents

Patent 1518151.4 : Patent application

Disclosures

Invention disclosures registered with UCD technology transfer office (UCD Nova). Inventor(s):Ni Ainle, Fionnuala, Submitted: 01-JAN-16
 

Conference Contributions

Egan, K; Hui, Ma; Kevane, B; Lennon, A; Allen, S; Neary, E; Wynne, K; O¿Shea, S; O¿Kennedy, R; Ní Áinle, F (2015) Platelet-derived β-thromboglobulin: a potential novel activator of coagulation factor X. [Oral Presentation], Haematology Association of Ireland Annual Meeting, Galway , 16-OCT-15 - 17-OCT-15.
Egan, K; Ma, Hui; Kevane, B; Lennon, A; Allen, S; Neary, E; Wynne, K; O¿Shea, S; O¿Kennedy, R; Ní Áinle, F (2015) . Platelet-derived beta thromboglobulin: a potential novel activator of coagulation factor X. [Poster Presentation], 57th Annual Meeting of American Society of Hematology, Orlando, Florida , 05-DEC-15 - 08-DEC-15.
Egan, K; Hui, Ma; Kevane, B; Lennon, A; Allen, S; Neary, E; Wynne, K; O¿Shea, S; O¿Kennedy, R; Ní Áinle, (2015) Platelet-derived β-thromboglobulin: a potential novel activator of coagulation factor X. [Poster Presentation (Refereed)], UCD Conway Institute Research Festival, UCD , 09-SEP-15 - 10-SEP-15.
Kevane, B; Walsh, K; Allen, S; Egan, K; Szklanna, P; Maguire, P; Savage, R; Doran, E; Neary, E; Ní Ainle, F (2015) Plasma thrombin generation in platelet-rich plasma is enhanced in patients with Eisenmenger syndrome. [Poster Presentation], Haematology Association of Ireland Annual Meeting, Galway , 16-OCT-15 - 17-OCT-15.
Kevane, B; Egan, K; Maguire, P; Neary, E; Allen, S; Lennon, Á; Ní Áinle, F (2015) Low molecular weight heparin (LMWH) & fractions of LMWH with diminished anticoagulant activity support endothelial barrier function. [Poster Presentation], Haematology Association of Ireland Annual Meeting, Galway , 16-OCT-15 - 17-OCT-15.
Egan, K; Dunne, E; Dillon, A; Kevane, B; Galvin, Z; Kenny, D; Stewart, S; Ní Áinle, F (2015) Increased soluble GPVI levels in cirrhosis: evidence for collagen induced platelet activation in vivo. [Poster Presentation], 57th Annual Meeting of American Society of Hematology, Orlando, Florida , 05-DEC-15 - 08-DEC-15.
Dillon, A; Egan, K; Galvin, Z; Kevane, B; Neary, E; Ní Áinle, F; Stewart, (2015) Thrombin generation varies with fibrosis score in patients with well-compensated liver cirrhosis of mixed aetiology. [Poster Presentation], Irish Society of Gastroenterology Summer, Kildare , 04-JUN-15 - 05-JUN-15.
Neary, E; McCallion, N; Kevane, B; Egan, K; Cotter, M; Ní Áinle, F (2015) The anticoagulant action of activated protein C in very preterm infants. [Oral Presentation], Joint European Neonatal Societies Congress, Budapest , 16-SEP-15 - 20-SEP-15.
Egan, K; Dillon, A; Galvin, Z; Kevane, B; Neary, E; Stewart, S; Ní Áinle, F (2015) Thrombin generation varies with fibrosis score in patients with well-compensated liver cirrhosis of mixed aetiology. [Oral Presentation], International Society on Thrombosis and Haemostasis Congress, Toronto , 20-JUN-15 - 25-JUN-15.
Mitchell, DP; Rowan, M; Crockett, M; Ni Ainle, F; Mac Mahon, P (2015) CTPA bolus timing techniques in pregnancy: an underappreciated contributor to breast radiation dose. [Oral Presentation], European Congress of Radiology, Vienna , 04-MAR-15 - 08-MAR-15.
O¿Connor, H; Egan, K; Kevane, B; Malone, F; Cooley, S; Geary, M; Maguire, P; Sklanna, P; Tully, E; Neary, E; O¿Loughlin, J; Allen, S; McCallion, N; Ní, Áinle F (2016) Coagulation balance in early onset preeclampsia (EOP). [Poster Presentation], Society for Maternal-Fetal Medicine Annual Meeting, Atlanta, Georgia , 01-FEB-16 - 06-FEB-16.
Cooley, S; Donnelly, JC; Deering, M; Raman, A; O¿Reilly, M; Gannon, G; Holland, A; O¿Shaughnessy, F; Brady, M; Hayes, N; Ní Áinle, F; Cleary, B (2016) Thrombocalc: Personalized postpartum VTE risk assessment in a high-throughput environment. [Invited Oral Presentation], Society for Maternal-Fetal Medicine Annual Meeting, Georgia, Alanta, USA , 01-FEB-16 - 06-FEB-16.
Egan, K; Kevane, B; Neary, E; Ni Ainle, F (2014) B-Thromboglobulin accelerates thrombin generation. [Poster Presentation], Haematology Association of Ireland Meeting, Sligo , 17-OCT-14 - 18-OCT-14.
McDonnell, B; Kevane, B; Raman, A; Deering, M; Holland, A; Cooley, S; Ni Ainle, F; Cleary, B (2014) Introducing thrombocalc: a new tool to risk assess venous thromboembolism risk in pregnant patients. [N/A], Junior Obstetrics and Gynaecology Society of Ireland, Dublin , 28-NOV-14 - 28-NOV-14.
Kevane, B; Egan, K; Neary, E; Ni Ainle, F (2014) Low molecular weight heparin (LMWH) inhibits thrombin and VEGF induced endothelial permeability. [Poster Presentation], Haematology Association of Ireland Meeting, Sligo , 17-OCT-14 - 18-OCT-14.
Neary, E; McCallion, N; Kevane, B; Egan, K; Cotter, M; Corcoran, D; Hayes, B; Regan, I; Foran, A; Ni Ainle, F (2014) To characterise standard laboratory coagulation parameters and plasma thrombin generation in very preterm infants and to investigate their relationship to clinical outcomes. [Oral Presentation], Haematology Association of Ireland Meeting, Sligo , 17-OCT-14 - 18-OCT-14.
Crowley, MP; Kevane, B; O'Shea, S; Eustace, JA; Quinn, S; Egan, K; Gilligan, OM; Ní Áinle, F (2014) Patterns of thrombin generation and sensitivity to the anticoagulant activated protein C in patients with myeloma and monoclonal gammopathy of undetermined significance. [Poster Presentation], European Haematology Association Conference, Milan , 12-JUN-14 - 15-JUN-14.
O'Connor, H; Kevane, B; Cooley, S; Egan, K; Flood, K; Ní Áinle, F (2014) The effect of morbid obesity on thrombin generation and sensitivity to the anticoagulant activated protein C in pregnant women. [Poster Presentation], European Haematology Association Conference, Milan , 12-JUN-14 - 15-JUN-14.
O'Connor, H; Kevane, B; Cooley, S; Egan, K; Flood, K; Ní Áinle, F (2014) The effect of morbid obesity on thrombin generation and sensitivity to the anticoagulant activated protein C in pregnant women. [Oral Presentation], Perinatal Medicine: British Maternal Fetal Medicine Society, Harrogate , 09-JUN-14 - 11-JUN-14.
Caulfield, K; Hayes, N; Ryan Enright, S; Murphy, D; Ni Ainle, F (2014) To determine the potential implications of implementation of updated guidelines for blood grouping prior to blood transfusion (BCSH; 2012) in the Rotunda Maternity Hospital: a retrospective audit. [Oral Presentation], Irish Society of Obstetric Anaesthesia Conference, CAI, Dublin , 05-DEC-14 - 05-DEC-14.
Neary, E; McCallion, N; Kevane, B; Cotter, M; Egan, K; Regan, I; Ní Áinle, F (2014) To characterise standard laboratory coagulation parameters and plasma thrombin generation in very preterm infants and to investigate their relationship to clinical outcomes. [Poster Presentation], American Society of Hematology Conference, San Francisco , 06-DEC-14 - 06-DEC-14.
Kevane, B; McKenna, P; Walsh, K; Donnelly, J; Flood, K; Cullen, M; Bowen, M; Thornton, P; Loughrey, J; Ní Áinle, F (2014) Haematological morbidity in obstetric patients with acquired and congenital cardiac disease. [Poster Presentation], European Haematology Association Conference, Milan , 12-JUN-14 - 15-JUN-14.
Kevane, B; Egan, K; Neary, E; Ni Ainle, F (2014) Low molecular weight heparin (LMWH) inhibits thrombin and VEGF induced endothelial permeability. [Oral Presentation], Contemporary Issues in Hospital Practice Conference, UCD , 06-NOV-14 - 06-NOV-14.
Kevane, B; Egan, K; Neary, E; Ni Ainle (2014) Low molecular weight heparin (LMWH) inhibits thrombin and VEGF induced endothelial permeability. [Oral Presentation], Biochemical Society Irish Area Section Annual Meeting, Dublin , 12-NOV-14 - 12-NOV-14.
Egan, K; Kevane, B; Neary, E; Ni Ainle, F (2014) B-Thromboglobulin accelerates thrombin generation. [Poster Presentation], Biochemical Society Irish Area Section Annual Meeting, Dublin , 12-NOV-14 - 12-NOV-14.
Keating, N; Cooley, S; Raman, A; Deering, M; Holland, A; Cleary, B; Ni Ainle, F (2014) What percentage of women who qualify for postpartum thromboprophylaxis following venous thromboembolism risk assessment at delivery can be identified by antenatal risk assessment?. [N/A], Junior Obstetrics and Gynaecology Society of Ireland, Dublin , 28-NOV-14 - 28-NOV-14.
Crowley, MP; Kevane, B; O'Shea, SI; Egan, S; Quinn, S; Gilligan, O; Ni Ainle, F (2014) Evolving patterns of thrombin generation and sensitivity to activated protein C in patients with myeloma at diagnosis and in response to therapy. [Poster Presentation], Haematology Association of Ireland Meeting, Sligo , 17-OCT-14 - 18-OCT-14.
Doyle, A; Donnelly, J; Cooley, S; Campbell, S; Murphy, D; Corcoran, D; Kumpel, B; Ni Ainle, F (2013) Testing for fetomaternal haemorrhage by acid elution can yield false positive results in the presence of elevated maternal fetal haemoglobin. [Poster Presentation], British Maternal and Foetal Medicine Society Conference, Dublin , 25-JUN-13 - 26-JUN-13.
Monteith, C; Eogan, M; Cooley, S; Lambert, J; Kelleher, B; Ni Ainle, F (2013) Hepatitis C virus associated immune thrombocytopenia in pregnancy: pregnancy management and morbidity. [Poster Presentation], British Maternal and Foetal Medicine Society Conference, Dublin , 25-APR-13 - 26-APR-13.
Hazell, M; Reyland, L; Ní Áinle, F; Donnelly, JC; Kumpel, B (2013) Persistence of fetal haemoglobin as a cause of false positive Kleihauer-betke (acid elution) tests and excessive prophylactic Anti-D administration. [Poster Presentation], 23rd Regional Conference of the International Society of Blood Transfusion, Amsterdam , 02-JUN-13 - 05-JUN-13.
Ryan, K; Goodyer, M; O'Connell, N; Gilmore, R; Ní Áinle, F; Jenkins, V; Fagan, P; Young, V; O'Donnell, JS (2013) Anticoagulation for patients with antiphosphilipid antibodies undergoing cardiopulmonary bypass - a novel strategy for optimisation of heparin anticoagulation. [Poster Presentation], XXIVth Congress of the International Society for Haemostasis and Thrombosis Conference, Amsterdam , 29-JUN-13 - 04-JUL-13.
Gleeson, E; Ní Áinle, F; Kenny, BA; O'Donnell, JS; Preston, RJ (2013) Activated protein C glycosylation status dictates protease-activated receptor 1 proteolysis and anti-inflammatory signaling efficacy. [Oral Presentation], XXIVth Congress of the International Society on Thrombosis and Haemostasis, Amsterdam, Netherlands , 29-JUN-13 - 04-JUL-13.

Committees

Committee : MMUH/Rotunda Hospital Maternal Medicine Working Group
Committee : MMUH Venous Thromboembolism Working Group
Committee : Scientific Committee, Haematology Association of Ireland
         

Journals Edited

Journal Of Maternal-Fetal And Neonatal Medicine: Reviewer.
Irish Journal Of Medical Science: Reviewer.
Blood: Reviewer.
 

Publications

     

Peer Reviewed Journals

Donnelly JC, Cooley SM;Doyle A;Murphy D;Corcoran D;Kumpel B;N¿¿ Ainle F (2013) 'False positive Kleihauer-Betke (acid elution) test caused by elevated maternal fetal haemoglobin F cells'. European Journal of Obstetrics & Gynecology and Reproductive Biology, 172 :136-137. [DOI] [Details]
Rigney, Tara and Cooley, Sharon and Kevane, Barry and Ryan, Kevin and Byrne, Mary and Ni Ainle, Fionnuala (2013) 'Antenatal identification of factor VII Padua during a healthy pregnancy: implications for labor and delivery'. Journal of Perinatal Medicine, 3 . [DOI] [Details]
Monteith, C. and Ni Ainle, F. and Cooley, S. and Lambert, J. S. and Kelleher, B. and Jackson, V. and Eogan, M. (2014) 'Hepatitis C virus-associated thrombocytopenia in pregnancy: impact upon multidisciplinary care provision'. J Perinat Med, 42 (1):135-8. [DOI] [Details]
Monteith, C. and Ni Ainle, F. and Cooley, S. and Lambert, J. S. and Kelleher, B. and Jackson, V. and Eogan, M. (2014) 'Hepatitis C virus-associated thrombocytopenia in pregnancy: impact upon multidisciplinary care provision'. J Perinat Med, 42 (1):135-8. [DOI] [Details]
Gleeson, Eimear M. and O'Donnell, James S. and Hams, Emily and Ni Ainle, Fionnuala and Kenny, Bridget-Ann and Fallon, Padraic G. and Preston, Roger J. S. (2014) 'Activated factor X signaling via protease-activated receptor 2 suppresses pro-inflammatory cytokine production from lipopolysaccharide-stimulated myeloid cells'. Haematologica, 99 :185-93. [Details]
Neary E, Ni Ainle F;Cotter M;McCallion N (2014) 'Coagulation values in extreme premature infants'. Transfusion, 54 (8). [DOI] [Details]
Egan K; Dillon A; Dunne E; Kevane B; Galvin Z; Maguire P; Kenny D; Stewart S; Ainle FN (2016) 'Increased soluble GPVI levels in cirrhosis: evidence for early in vivo platelet activation'. Journal of Thrombosis and Thrombolysis, . [Details]
Bleker, Suzanne M. and Buchmuller, Andrea and Chauleur, Celine and Ni Ainle, Fionnuala and Donnelly, Jennifer and Verhamme, Peter and Jacobsen, Anne Flem and Ganzevoort, Wessel and Prins, Martin and Beyer-Westendorf, Jan and DeSancho, Maria and Konstantinides, Stavros and Pabinger, Ingrid and Rodger, Marc and Decousus, Herve and Middeldorp, Saskia (2016) 'Low-molecular-weight heparin to prevent recurrent venous thromboembolism in pregnancy: Rationale and design of the Highlow study, a randomised trial of two doses'. Thrombosis research, 144 :62-8. [Details]
Neary, Elaine and Ni Ainle, Fionnuala and El-Khuffash, Afif and Cotter, Melanie and Kirkham, Colin and McCallion, Naomi (2016) 'Plasma transfusion to prevent intraventricular haemorrhage in very preterm infants'. Cochrane Database of Systematic Reviews, (9). Available Online [Details]
Parsons ME; O'Connell K; Allen S; Egan K; Szklanna PB; McGuigan C; Ni Ainle F; Maguire PB (2017) 'Thrombin generation correlates with disease duration in multiple sclerosis (MS): Novel insights into the MS-associated prothrombotic state'. Multiple sclerosis journal - experimental, translational and clinical, 3 (4). [DOI] [Details]
Monteith C; Egan K; O'Connor H; Maguire P; Kevane B; Szklanna PB; Cooley S; Malone F; Ni Ainle FN (2017) 'Early onset preeclampsia is associated with an elevated mean platelet volume (MPV) and a greater rise in MPV from time of booking compared with pregnant controls: results of the CAPE study'. Journal of Perinatal Medicine, . [DOI] [Details]
Egan K, van Geffen JP;Ma H;Kevane B;Lennon A;Allen S;Neary E;Parsons M;Maguire P;Wynne K;O' Kennedy R;Heemskerk JWM; Ni Ainle FN (2017) 'Effect of platelet-derived beta-thromboglobulins on coagulation'. Thrombosis Research, 154 :7-15. [DOI] [Details]
Szklanna PB; Wynne K; Nolan M; Egan K; Ni Ainle FN; Maguire PB (2017) 'Comparative proteomic analysis of trophoblast cell models reveals their differential phenotypes, potential uses and limitations'. Proteomics, . [DOI] [Details]
Egan K; Dillon A; Dunne E; Kevane B; Galvin Z; Maguire P; Kenny D; Stewart S; Ainle FN (2017) 'Increased soluble GPVI levels in cirrhosis: evidence for early in vivo platelet activation'. Journal of Thrombosis and Thrombolysis, 43 (1):54-59. [DOI] [Details]
Kevane, Barry and Ainle, Fionnuala Ni (2017) 'Contraception and menstrual bleeding during venous thromboembolism treatment: Does current practice reflect expert option?'. Thrombosis Research, :121-122. [DOI] [Details]
Barrett, Aisling and Kevane, Barry and Hall, Patricia and Ni Ainle, Fionnuala and Breslin, Tomas (2017) 'Screening for Malignancy in Patients With Unprovoked Venous Thromboembolism: A Single-Center Retrospective Case Series'. Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis, 23 :735-739. [Details]
Barry Kevane and Karl Egan and Seamus Allen and Patricia Maguire and Elaine Neary and Áine Lennon and Fionnuala Ní Áinle (2017) 'Endothelial barrier protective properties of low molecular weight heparin: A novel potential tool in the prevention of cancer metastasis?'. Research and Practice in Thrombosis and Haemostasis, 1 (1):23-32. Available Online [DOI] [Details]
O'Shaughnessy, Fergal and Donnelly, Jennifer C. and Cooley, Sharon M. and Deering, Mary and Raman, Ajita and Gannon, Geraldine and Hickey, Jane and Holland, Alan and Hayes, Niamh and Bennett, Kathleen and Ni Ainle, Fionnuala and Cleary, Brian J. (2017) 'Thrombocalc: implementation and uptake of personalized postpartum venous thromboembolism risk assessment in a high-throughput obstetric environment'. Acta obstetricia et gynecologica Scandinavica, 96 :1382-1390. [Details]
Egan, Karl and O'Connor, Hugh and Kevane, Barry and Malone, Fergal and Lennon, Aine and Al Zadjali, Amani and Cooley, Sharon and Monteith, Cathy and Maguire, Patricia and Szklanna, Paulina B. and Allen, Seamus and McCallion, Naomi and Ni Ainle, Fionnuala (2017) 'Elevated plasma TFPI activity causes attenuated TF-dependent thrombin generation in early onset preeclampsia'. Thrombosis and haemostasis, 117 :1549-1557. [Details]
McDonnell, Brendan P. and Glennon, Kate and McTiernan, Aoife and O'Connor, Hugh D. and Kirkham, Colin and Kevane, Barry and Donnelly, Jennifer C. and Ni \'Ainle, Fionnuala (2017) 'Adjustment of therapeutic LMWH to achieve specific target anti-FXa activity does not affect outcomes in pregnant patients with venous thromboembolism'. Journal of Thrombosis and Thrombolysis, 43 (1):105-111. Available Online [DOI] [Details]
Parsons MEM, McParland D;Szklanna PB;Guang MHZ;O'Connell K;O'Connor HD;McGuigan C;Ni Ainle F;McCann A;Maguire PB (2017) 'A Protocol for Improved Precision and Increased Confidence in Nanoparticle Tracking Analysis Concentration Measurements between 50 and 120 nm in Biological Fluids'. Frontiers in cardiovascular medicine, 4 . [DOI] [Details]
Maguire PB; Donlon T; Parsons M; Wynne K; Dillon E; Ni Ainle F; Szklanna PB (2018) 'Proteomic Analysis Reveals a Strong Association of beta-Catenin with Cadherin Adherens Junctions in Resting Human Platelets'. Proteomics, . [DOI] [Details]
Crowley, M; Kevane, B; O'Shea, S; Quinn, S; Egan, K; Gilligan, O; Ní Áinle, F (2016) 'Plasma Thrombin Generation and Sensitivity to Activated Protein C Among Patients With Myeloma and Monoclonal Gammopathy of Undetermined Significance'. Clinical and Applied Thrombosis/Hemostasis, . [Details]
Husarova V, Donnelly G;Doolan A;Garstka M;Ni Ainle F;McCaul C (2015) 'Preferences of Jehovah's Witnesses regarding haematological supports in an obstetric setting: experience of a single university teaching hospital'. International Journal of Obstetric Anesthesia, . [DOI] [Details]
Werth S, Breslin T;NiAinle F;Beyer-Westendorf J (2015) 'Bleeding Risk, Management and Outcome in Patients Receiving Non-VKA Oral Anticoagulants (NOACs)'. American Journal of Cardiovascular Drugs, 15 (4):235-242. [DOI] [Details]
Kevane, B; McKenna, P; Walsh, K; Donnelly, JC; Flood, K; Cullen, M; Bowen, M; Thornton, P; Loughrey, J; Coulter-Smith, S; Ní Áinle, F (2015) 'Haemorrhagic and thrombotic complications in pregnant women with acquired and congenital cardiac disease'. Journal of Perinatal Medicine, 43 (2):165-169. [Details]
Egan, K; Kevane, B; Ní Áinle F (2015) 'Elevated venous thromboembolism risk in preeclampsia: molecular mechanisms and clinical impact'. Biochemical Society Transactions, 43 (4):696-701. [Details]
Neary, E; McCallion, N; Kevane, B; Cotter, M; Egan, K; Regan, I; Kirkham, C; Mooney, C; Coulter-Smith, S; Ní Áinle, F (2015) 'Coagulation indices in very preterm infants from cord blood and postnatal samples'. Journal of thrombosis and haemostasis : JTH, 13 (11):2021-2030. [Details]
Langabeer SE, Haslam K;Linders J;Percy MJ;Conneally E;Hayat A;Hennessy B;Leahy M;Murphy K;Murray M;Ni Ainle F;Thornton P;Sargent J (2014) 'Molecular heterogeneity of familial myeloproliferative neoplasms revealed by analysis of the commonly acquired JAK2, CALR and MPL mutations'. Familial Cancer, 13 (4):659-663. [DOI] [Details]
Neary, E; Ni Ainle, F; Cotter, M; McCallion, N (2014) 'Reference intervals for common coagulation tests of preterm infants (CME)'. Transfusion, 54 (3):627-632. [Details]
Murphy NC, Hayes NE;Ainle FB;Flood KM (2014) 'Jehovah's Witness patients presenting with ruptured ectopic pregnancies: two case reports'. Journal of Medical Case Reports, 8 . [DOI] [Details]
Corcoran D, Murphy D;Donnelly JC;Ainle FN (2014) 'The prevalence of maternal F cells in a pregnant population and potential overestimation of foeto-maternal haemorrhage as a consequence'. Blood Transfusion, 12 (4):570-574. [DOI] [Details]
Donnellan E, Kevane B;Bird BR;Ainle FN (2014) 'Cancer and venous thromboembolic disease: from molecular mechanisms to clinical management'. Current Oncology, 21 (3):134-143. [DOI] [Details]
Kevane B, Donnelly J;D'Alton M;Cooley S;Preston RJ;N¿¿ Ainle F (2014) 'Risk factors for pregnancy-associated venous thromboembolism: a review'. Journal of Perinatal Medicine, 42 (4):417-425. [DOI] [Details]
Scully M, Thomas M;Underwood M;Watson H;Langley K;Camilleri RS;Clark A;Creagh D;Rayment R;Mcdonald V;Roy A;Evans G;McGuckin S;Ni Ainle F;Maclean R;Lester W;Nash M;Scott R;O Brien P; (2014) 'Thrombotic thrombocytopenic purpura and pregnancy: presentation, management, and subsequent pregnancy outcomes'. Blood, 124 (2):211-219. [DOI] [Details]
Neary E, Okafor I;Al-Awaysheh F;Kirkham C;Sheehan K;Mooney C;Foran A;Corcoran JD;Ni Ainle F;Cotter M;McCallion N (2013) 'Laboratory coagulation parameters in extremely premature infants born earlier than 27 gestational weeks upon admission to a neonatal intensive care unit'. Neonatology, 104 (3):222-227. [DOI] [Details]
N¿¿ Ainle F, O'Donnell JS;Johnson JA;Brown L;Gleeson EM;Smith OP;Preston RJ (2011) 'Activated protein C N-linked glycans modulate cytoprotective signaling function on endothelial cells'. Journal of Biological Chemistry, 286 (2):1323-1330. [DOI] [Details]
Ni Ainle F, Preston RJ;Jenkins PV;Nel HJ;Johnson JA;Smith OP;White B;Fallon PG;O'Donnell JS (2009) 'Protamine sulfate down-regulates thrombin generation by inhibiting factor V activation'. Blood, 114 (8):1658-1665. [DOI] [Details]
Preston, RJ; Tran, S; Johnson, JA; Ní Áinle, F; Harmon, S; White, B; Smith, OP; Jenkins, PV; Dahlbäck, B; O'Donnell, JS (2009) 'Platelet factor 4 impairs the anticoagulant activity of activated protein C'. The Journal of biological chemistry, 284 (9):5869-5875. [Details]
Harmon S, Preston RJ;Ni Ainle F;Johnson JA;Cunningham MS;Smith OP;White B;O'Donnell JS (2008) 'Dissociation of activated protein C functions by elimination of protein S cofactor enhancement'. Journal of Biological Chemistry, 283 (45):30531-30539. [DOI] [Details]
N¿¿ Ainle F, Wong A;Appleby N;Byrne B;Regan C;Hassan T;Milner M;Sullivan AO;White B;O'Donnell J (2008) 'Efficacy and safety of once daily low molecular weight heparin (tinzaparin sodium) in high risk pregnancy'. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 19 (7):689-692. [DOI] [Details]
Ainle FN, Mumford A;Tallon E;McCarthy D;Murphy K (2008) 'A vitamin K epoxide reductase complex subunit 1 mutation in an Irish patient with warfarin resistance'. Irish Journal of Medical Science, 177 (2):159-161. [DOI] [Details]
Langabeer SE, Ni Ainle F;Conneally E;Lawler M (2007) 'Incidence and significance of the JAK2 V617F mutation in patients with chronic myeloproliferative disorders'. Irish Journal of Medical Science, 176 (2):105-109. [DOI] [Details]
Hayden PJ, O'Driscoll A;Gardiner N;Swords R;Sargent J;Ni Ainle F;Fortune A;Murphy PT;Leahy M;Jackson F;Ryan M;Hennessy B;Cahill M;Crotty GM;Enright H;Conneally E;Vandenberghe E;McCann SR;Browne PV (2005) 'Autologous stem cell transplantation in myeloma: the St James's Hospital experience, 1997-2003'. Irish Journal of Medical Science, 174 (2):26-32. [Details]
                                                                                                                     

Other

N¿¿ Ainle F, Hayden PJ;Crosby P;Murphy K;McCarthy D;Kelly J;Neat MJ (2006) Concurrent rearrangement of BCL1 and BCL6 with a single immunoglobulin locus in a case of diffuse large B-cell lymphoma. Other [DOI] [Details]
                   

Research

Research Interests

Current SPHERE research projects

Dr Karl Egan, Postdoctoral fellow.  Project Title: Novel approaches to determining the procoagulant state in early-onset pre-eclampsia: diagnostic relevance and therapeutic opportunities; Funding: HRB

Dr Seamus Allen, Postdoctoral fellow: Project Title:  Characterisation of plasma in adults with pulmonary hypertension secondary to congenital cardiac disease; Funding: Actelion Pharmaceutials LtD

Dr Barry Kevane, PhD fellow. Project Title:  Beneficial anticoagulant and cytoprotective properties of low molecular weight heparin in cancer ; Funding: Leo Laboratories

Mr Tim Donlon, PhD student. Project Title: WNT signalling in platelets; Funding: SFI

Ms Paulina Szklanna, PhD student. Project Title: The platelet releasate in Early-onset Preeclampsia; Funding: IRC PhD scholarship award

Mr Martin Parsons, PhD student. Project Title:   The platelet releasate in Multiple Sclerosis; Funding: UCD SBBS


Research Projects

Sponsor : Health Research Board (HRB)
Title : Novel approaches to determining procoagulant state in early onset preeclampsia: diagnostic relevance and therapeutic opportunities
Start Date / End Date : 01-OCT-13 / 31-MAY-17
Sponsor : Actelion Pharmaceuticals UK Ltd
Title : To characterize the effect of the Endothelin-1 receptor antagonist Masitentan ® on plasma thrombin generation in children and adults with pulmonary hypertension due to cyanotic congenital heart disease.
Start Date / End Date : 26-JAN-15 / 25-JAN-17
Sponsor : Leo Laboratories Ltd
Title : To investigate potential protective signalling mechanisms of LMWH Tinzaparin in vitro
Start Date / End Date : 01-APR-14 / 31-OCT-14
Sponsor : Science Foundation Ireland (SFI)
Title : Optimization of low molecular weight heparin (LMWH) endothelial protective properties: towards novel prevention strategies in cancer metastasis
Start Date / End Date : 01-JAN-16 / 31-MAR-17
Sponsor : Science Foundation Ireland (SFI)
Title : VTE Conference 19/09/15
Start Date / End Date : 01-JUN-15 / 29-FEB-16
Sponsor : Health Research Board (HRB)
Title : Thrombosis risk in pregnancy: what you need to know
Start Date / End Date : 18-DEC-15 / 17-DEC-16
Sponsor : Science Foundation Ireland (SFI)
Title : Venous Thromboembolism (VTE) Dublin 2016
Start Date / End Date : 01-JUN-16 / 30-NOV-16
Sponsor : Leo Laboratories Ltd
Title : A pre-clinical trial to investigate protective signalling of low molecular with heparin (LWMH) on endothelial cells in vitro: translational relevance for patients with cancer
Start Date / End Date : 01-JAN-16 / 01-JAN-18
   

Teaching

Teaching Philosophy

To teach students to understand physiological and disease processes in a way that enables them to approach, diagnose and manage patients with excellence and compassion, always striving to identify opportunities to improve patient care through translational research.
         

Collaborators

Internal Collaborators

Current SPHERE collaborators

Prof Peter Kelly

Prof Sean Murphy, MMUH Dept. of Stroke Medicine

Dr Stephen Stewart, Consultant Hepatologist, MMUH

 

Prof Fergal Malone, Master, Rotunda Hospital

Prof Naomi McCallion, Consultant Neonatologist, Rotunda Hospital

Dr Jennifer Donnelly, Consultant Obstetrician, Rotunda Hospital

Prof Brian Cleary, Chief Pharmacist, RCSI and Rotunda Hospital

Dr Kevin Walsh, Consultant Cardiologist, Mater Misericordiae University Hospital

Dr Tomás Breslin, Consultant in Emergency Medicine, Mater Misericordiae University Hospital and Chair, Mater Hospital Venous Thromboembolism Working Group

Prof Louise Kenny, Infant Research Centre, UCC

Dr Jogin Thakore, Consultant Psychiatrist, St Vincent¿s Hospital, Fairview

Prof Sean Gaine, Consultant Respiratory Physician, Mater Misericordiae University Hospital

External Collaborators

Prof Saskia Middeldorp, Academic Medical Centre, the Netherlands

Prof Beverley Hunt, King¿s College, London

Dr Chris McGuigan, SVUH

Dr Alastair Poole, Bristol University

Prof Johan Heemskeerk, Maastricht University

Prof Denisa Wagner, Harvard Medical School