Researchers at UCD


Glen Doherty

Clinical Professor

School Of Medicine
St Vincent's Hospital
Elm Park
Dublin 4

Tel: (01)2214711


Glen Doherty graduated from Trinity College Dublin in 1998 with a Gold Medal and 1st Class Hons Degree in Medicine. Having obtained Membership of the Royal College of Physicians of Ireland (MRCPI) in 2001, he entered a specialist training programme in Gastroenterology. During this he completed a PhD degree (2006) in the area of colorectal cancer at RCSI medical school and the Conway Institute at UCD, focusing on eicosanoid signalling pathways. Following the award of his Certificate of Specialist Training in Gastroenterology and Internal Medicine in 2008, he spent a period of further specialist training in the USA at Beth Israel Deaconess Medical Centre and Harvard Medical School, Boston, MA. Here he undertook a post-doctoral research programme with Professor Simon Robson. He returned to Ireland in 2010 to take up a position as a Consultant Gastroenterologist at the Centre for Colorectal Disease at St Vincent's University Hospital and UCD. Glen has numerous peer-reviewed publications in the areas of inflammatory bowel disease and colorectal cancer and is Research Director of the Centre for Colorectal Disease. He is played a leading role in achieving JAG accreditation for the SVUH endoscopy unit, the first unit in the Republic of Ireland to achieve accreditation. Glen co-ordinates the hand-on teaching programme for Advanced Nurse Practioners training to become Nurse Endoscopists in Association with The UCD School of Nursing and Midwifery. Glen organises the only colonoscopy 'train the trainer courses' in the Republic of Ireland in association with RCPI. He is Honorary Treasurer and an Executive Board member of the Irish Society of Gastroenterology (ISG) and is National Representative and member of the Guidelines Committee (GUI-COM) for the European Crohn's and Colitis Organisation (ECCO).


Honours and Awards

Year: 1998.
Title: Sir James Craig Memorial Prize
Year: 1998.
Title: Lorna Joan Rust Medal for Obstetrics
Year: 1998.
Title: Professors Prize for Psychiatry
Year: 1998.
Title: Hutchinson Bequest & Fitz-Patrick Scholarship
Year: 1999.
Title: Blaney Medal
Year: 1998.
Title: Reuben Harvey Prize
Year: 2008.
Title: Sheppard Memorial Prize & Sir John Banks Medal in Medicine


Association: European Board of Gastroenterology and Hepatology, Function/Role: Fellowship
Association: Irish Society of Gastroenterology, Function/Role: Board Member
Association: European Crohn's and Colitis Organisation, Function/Role: National Representative, Member
Association: Royal College of Physicians of Ireland, Function/Role: Fellow
Association: American Gastroenterological Association, Function/Role: Member
Association: Crohns and Colitis Foundation of America, Function/Role: Physician member

Conference Contributions

Doherty, G (2012) Medical management of difficult Crohn's disease. [Invited Lecture], Association of Coloproctology of GB & Ireland, Annual Meeting, Dublin , 02-JUL-12 - 02-JUL-12.
Doherty, G (2013) Stopping therapy in IBD; is it ever safe?. [Invited Lecture], British, Irish, Ulster Societies of Gastroenterology, BIG Meeting, Belfast , 25-APR-13 - 25-APR-13.
Doherty, G (2014) What's new in IBD research 2014 and beyond?. [Invited Lecture], 6th Annual Galway IBD Study Day, Galway , 04-OCT-14 - 04-OCT-14.
Doherty, G (2015) Medical management of severe ulcerative colitis. [Invited Lecture], European Society of Coloproctology, Dublin , 23-SEP-15 - 25-SEP-15.


Committee : Guidelines Committee - European Crohn's and Colitis Organisation (ECCO)
Committee : Nutrition Committee, SVUH
Committee : National Electronic Endoscopy Reporting Systems, HSE


Employer: Beth Israel Deaconess Hospital/Harvard Medical School
Position: Advanced Inflammatory Bowel Disease Fellow


Year 2006 Institution: National University of Ireland, University College Dublin
Qualification: PhD Subject: Medicine
Year 1998 Institution: University of Dublin, Trinity College
Qualification: MB, BCh, BAO Subject: Medicine



Journals Edited

World Journal Of Gastroenterology : Wjg: Editorial Board member.
Journal Of Crohn'S & Colitis: Editorial Board member.



Book Chapters

Glen A. Doherty and Adam S. Cheifetz (2011) 'One drug or two: Do patients on biologics need concurrent immunomodulation?' In: Glen A. Doherty and Adam S. Cheifetz (eds). Clinical Dilemmas in Inflammatory Bowel Disease: New Challenges. United Kingdom: Wiley-Blackwell. [Details]

Peer Reviewed Journals

Doherty G, Katsanos KH;Burisch J;Allez M;Papamichael K;Stallmach A;Mao R;Berset IP;Gisbert JP;Sebastian S;Kierkus J;Lopetuso L;Szymanska E;Louis E (2017) 'European Crohn's and Colitis Organisation Topical Review on Treatment Withdrawal ('Exit Strategies') in Inflammatory Bowel Disease'. Journal of Crohn's & colitis, . [DOI] [Details]
Gibson DJ, Hartery K;Doherty J;Nolan J;Keegan D;Byrne K;Martin ST;Buckley M;Sheridan J;Horgan G;Mulcahy HE;Cullen G;Doherty GA (2017) 'CRP/Albumin Ratio: An Early Predictor of Steroid Responsiveness in Acute Severe Ulcerative Colitis'. Journal of Clinical Gastroenterology, . [DOI] [Details]
Clowry J, Sheridan J;Healy R;Deady S;Keegan D;Byrne K;Cullen G;Mulcahy H;Comber H;Parnell AC;Doherty G;Lally A (2017) 'Increased non-melanoma skin cancer risk in young patients with inflammatory bowel disease on immunomodulatory therapy: a retrospective single-centre cohort study'. Journal of the European Academy of Dermatology and Venereology : JEADV, 31 (6):978-985. [DOI] [Details]
Hartery K, Lee CS;Doherty GA;Murray FE;Cullen G;Patchett SE;Mulcahy HE (2017) 'Covered self-expanding metal stents for the management of common bile duct stones'. Gastrointestinal Endoscopy, 85 (1):181-186. [DOI] [Details]
Dunne MR, Ryan C;Nolan B;Tosetto M;Geraghty R;Winter DC;O'Connell PR;Hyland JM;Doherty GA;Sheahan K;Ryan EJ;Fletcher JM (2016) 'Enrichment of Inflammatory IL-17 and TNF-alpha Secreting CD4(+) T Cells within Colorectal Tumors despite the Presence of Elevated CD39(+) T Regulatory Cells and Increased Expression of the Immune Checkpoint Molecule, PD-1'. Frontiers in Oncology, 6 . [DOI] [Details]
Sheridan J, Cullen G;Doherty G (2017) 'Letter: Vedolizumab in Pregnancy'. Journal of Crohn's & colitis, 11 (8):1025-1026. [DOI] [Details]
Rowan CR, Cullen G;Mulcahy HE;Keegan D;Byrne K;Murphy DJ;Sheridan J;Doherty GA (2017) 'Ustekinumab drug levels in maternal and cord blood in a woman with Crohn's disease treated until 33 weeks gestation'. Journal of Crohn's & colitis, . [DOI] [Details]
Fitzpatrick SF, F¿¿bi¿¿n Z;Schaible B;Lenihan CR;Schwarzl T;Rodriguez J;Zheng X;Li Z;Tambuwala MM;Higgins DG;O'Meara Y;Slattery C;Manresa MC;Fraisl P;Bruning U;Baes M;Carmeliet P;Doherty G;von Kriegsheim A;Cummins EP;Taylor CT (2016) 'Prolyl hydroxylase-1 regulates hepatocyte apoptosis in an NF-kappaB-dependent manner'. Biochemical and Biophysical Research Communications, . [DOI] [Details]
Elliott LA, Doherty GA;Sheahan K;Ryan EJ (2017) 'Human Tumor-Infiltrating Myeloid Cells: Phenotypic and Functional Diversity'. Frontiers in Immunology, 8 . [DOI] [Details]
Taylor CT, Doherty G;Fallon PG;Cummins EP (2016) 'Hypoxia-dependent regulation of inflammatory pathways in immune cells'. The Journal of clinical investigation, 126 (10):3716-3724. [DOI] [Details]
Moran CP, Neary B;Doherty GA (2016) 'Endoscopic evaluation in diagnosis and management of inflammatory bowel disease'. World journal of gastrointestinal endoscopy, 8 (20):723-732. [DOI] [Details]
Mulcahy HE, McDermott E, Mullen G, Moloney J, Keegan D, Byrne K, Doherty GA, Cullen G, Malone K (2015) 'Body image dissatisfaction: clinical features, and psychosocial disability in inflammatory bowel disease'. Inflammatory Bowel Diseases, 21 (2):353-360. [DOI] [Details]
Murphy DJ, Smyth AE;McEvoy SH;Gibson DJ;Doherty GA;Malone DE (2015) 'Subclassification of small bowel Crohn's disease using magnetic resonance enterography: a review using evidence-based medicine methodology'. Clinical Radiology, . [DOI] [Details]
McDermott E, Ryan EJ;Tosetto M;Gibson D;Burrage J;Keegan D;Byrne K;Crowe E;Sexton G;Malone K;Harris RA;Kellermayer R;Mill J;Cullen G;Doherty GA;Mulcahy H;Murphy TM (2015) 'DNA methylation profiling in inflammatory bowel disease provides new insights into disease pathogenesis'. Journal of Crohn's and Colitis, . [DOI] [Details]
Walsh SM, Gallagher A, Gallagher R, Barnes E, Doherty GA, Dodd JD, Butler MW (2015) 'First do no harm: nasogastric tube placement and confirmation'. Qjm-An International Journal Of Medicine, . [DOI] [Details]
Gibson DJ, Elliott L, McDermott E, Tosetto M, Keegan D, Byrne K, Martin ST, Rispens T, Cullen G, Mulcahy HE, Cheifetz AS, Moss AC, Robson SC, Doherty GA, Ryan EJ (2015) 'Heightened Expression of CD39 by Regulatory T Lymphocytes Is Associated with Therapeutic Remission in Inflammatory Bowel Disease'. Inflammatory Bowel Diseases, . [DOI] [Details]
Gibson DJ, Murphy DJ, Smyth AE, McEvoy SH, Keegan D, Byrne K, Mulcahy HE, Cullen G, Malone DE, Doherty GA (2015) 'Magnetic resonance enterography findings as predictors of clinical outcome following antitumor necrosis factor treatment in small bowel Crohn's disease'. Journal of Gastroenterology, 27 (8):956-962. [DOI] [Details]
Keegan D, Byrne K, Cullen G, Doherty GA, Dooley B, Mulcahy HE (2015) 'The Stressometer: A Simple, Valid, and Responsive Measure of Psychological Stress in Inflammatory Bowel Disease Patients'. Journal of Crohn's and Colitis, 9 (10):881-885. [DOI] [Details]
Flood B, Oficjalska K, Laukens D, Fay J, O'Grady A, Caiazza F, Heetun Z, Mills KH, Sheahan K, Ryan EJ, Doherty GA, Kay E, Creagh EM (2015) 'Altered expression of caspases-4 and -5 during inflammatory bowel disease and colorectal cancer: Diagnostic and therapeutic potential'. Clinical and Experimental Immunology, . [DOI] [Details]
Caiazza F, Elliott L, Fennelly D, Sheahan K, Doherty GA, Ryan EJ (2015) 'Targeting EGFR in metastatic colorectal cancer beyond the limitations of KRAS status: alternative biomarkers and therapeutic strategies'. Biomarkers in Medicine, 9 (4):363-375. [DOI] [Details]
Lee CS, Murphy DJ, McMahon C, Nolan B, Cullen G, Mulcahy H, Sheahan K, Barnes E, Fennelly D, Ryan EJ, Doherty GA (2015) 'Visceral Adiposity is a Risk Factor for Poor Prognosis in Colorectal Cancer Patients Receiving Adjuvant Chemotherapy'. Journal of Gastrointestinal Cancer, . [DOI] [Details]
Lavelle A, Lennon G, O'Sullivan O, Docherty N, Balfe A, Maguire A, Mulcahy HE, Doherty G, O'Donoghue D, Hyland J, Ross RP, Coffey JC, Sheahan K, Cotter PD, Shanahan F, Winter DC, O'Connell PR (2015) 'Spatial variation of the colonic microbiota in patients with ulcerative colitis and control volunteers'. Gut, . [DOI] [Details]
Caiazza F, Ryan EJ, Doherty G, Winter DC, Sheahan K (2015) 'Estrogen receptors and their implications in colorectal carcinogenesis'. Frontiers in Oncology, 5 . [DOI] [Details]
Sheridan J, Walsh P, Kevans D, Cooney T, O'Hanlon S, Nolan B, White A, McDermott E, Sheahan K, O'Shea D, Hyland J, O'Donoghue D, O'Sullivan J, Mulcahy H, Doherty G (2014) 'Determinants of short- and long-term survival from colorectal cancer in very elderly patients'. Journal of Geriatric Oncology, . [DOI] [Details]
Gibson DJ, Heetun ZS, Redmond CE, Nanda KS, Keegan D, Byrne K, Mulcahy HE, Cullen G, Doherty GA (2014) 'An Accelerated Infliximab Induction Regimen Reduces the Need for Early Colectomy in Patients With Acute Severe Ulcerative Colitis'. Clinical Gastroenterology and Hepatology, . [DOI] [Details]
Gibson DJ, Gallagher CG, Doherty GA (2014) 'Infliximab is safe and induces sustained remission with complete mucosal healing in Crohn's disease in a patient with pan resistant pseudomonas cystic fibrosis: A case report'. Journal of Crohn's and Colitis, . [DOI] [Details]
Lee CS, Ryan EJ, Doherty GA (2014) 'Gastro-intestinal toxicity of chemotherapeutics in colorectal cancer: the role of inflammation'. World Journal of Gastroenterology, 20 (14):3751-3761. [DOI] [Details]
Spence AD, Lee R, Keegan D, Doherty GA, Mulcahy H, Murphy S (2014) 'Awareness of adverse effects of azathioprine in patients with inflammatory bowel disease--more to be done?'. Ulster Medical Journal, 83 (1):56-57. [Details]
O'Toole A, Coss A, Holleran G, Keegan D, Doherty G, Sheahan K, Mulcahy H, O'Donoghue D (2014) 'Microscopic colitis: clinical characteristics, treatment and outcomes in an Irish population'. Colorectal Disease, 29 (7):799-803. [DOI] [Details]
O'Toole A, Walsh P, Keegan D, Byrne K, Doherty G, O'Donoghue D, Mulcahy H (2014) 'Mortality in inflammatory bowel disease patients under 65 years of age'. Journal of Gastroenterology, 49 (7):814-819. [DOI] [Details]
Abdul-Jalil KI, Sheehan KM, Toomey S, Schmid J, Prehn J, O'Grady A, Cummins R, O'Neill B, McNamara DA, Deasy J, Breathnach O, Grogan L, Rogers A, Doherty G, Winter D, Ryan J, El-Masry S, Gibbons D, Sheahan K, Gillen P, Kay EW, Hennessy BT (2014) 'The frequencies and clinical implications of mutations in 33 kinase-related genes in locally advanced rectal cancer: a pilot study'. Annals of Surgical Oncology, 21 (8):2642-2649. [DOI] [Details]
Rahier JF, Magro F, Abreu C, Armuzzi A, Ben-Horin S, Chowers Y, Cottone M, de Ridder L, Doherty G, Ehehalt R, Esteve M, Katsanos K, Lees CW, Macmahon E, Moreels T, Reinisch W, Tilg H, Tremblay L, Veereman-Wauters G, Viget N, Yazdanpanah Y, Eliakim R, Colombel JF (2014) 'Second European evidence-based consensus on the prevention, diagnosis and management of opportunistic infections in inflammatory bowel disease'. Journal of Crohn's and Colitis, 8 (6):443-468. [DOI] [Details]
O'Toole A, Michielsen AJ, Nolan B, Tosetto M, Sheahan K, Mulcahy HE, Winter DC, Hyland JM, O'Connell PR, Fennelly D, O'Donoghue D, O'Sullivan J, Doherty GA, Ryan EJ (2014) 'Tumour microenvironment of both early- and late-stage colorectal cancer is equally immunosuppressive'. British Journal of Cancer, . [DOI] [Details]
McDermott E, Moloney J, Rafter N, Keegan D, Byrne K, Doherty GA, Cullen G, Malone K, Mulcahy HE (2014) 'The body image scale: a simple and valid tool for assessing body image dissatisfaction in inflammatory bowel disease'. Inflammatory Bowel Diseases, 20 (2):286-290. [DOI] [Details]
Heetun ZS, Keegan D, O'Donoghue D, Doherty GA (2014) 'Report of successful use of ustekinumab in Crohn's disease refractory to three anti-TNF therapies'. Irish Journal of Medical Science, . [DOI] [Details]
Cullen G, Doherty GA (2013) 'Management of complex colonic polyps in the English Bowel Cancer Screening Programme (Br J Surg 2013; 100: 1633-1639)'. British Journal of Surgery, 100 (12):1639-1640. [DOI] [Details]
Nowak-Machen M, Schmelzle M, Hanidziar D, Junger W, Exley M, Otterbein L, Wu Y, Csizmadia E, Doherty G, Sitkovsky M, Robson SC (2013) 'Pulmonary NKT Cells Play an Essential Role in Mediating Hyperoxic Acute LungInjury'. American Journal of Respiratory Cell and Molecular Biology, . [DOI] [Details]
Lavelle A, Lennon G, Docherty N, Balfe A, Mulcahy HE, Doherty G, O Donoghue D, Hyland JM, Shanahan F, Sheahan K, Coffey JC, Winter DC, O Connell PR (2013) 'Depth-dependent differences in community structure of the human colonic microbiota in health'. PLoS ONE, 8 (11). [DOI] [Details]
Burke JP, Oʼconnell RM, Lennon G, Doherty GA, Keegan D, Oʼdonoghue D, Mulcahy H, Hyland J, Winter DC, Sheahan K, Oʼconnell PR (2013) 'The Influence of CTGF Single-Nucleotide Polymorphisms on Outcomes in Crohn's Disease'. Annals of Surgery, 258 (5):767-774. [Details]
Heetun ZS, Kavanagh D, Keegan D, Mulcahy H, Hyland J, Mc Mahon C, Doherty GA (2013) 'Magnetic resonance colonography for assessment of acute severe colitis in pregnancy'. Medicine, . [DOI] [Details]
Gibson DJ, Ryan EJ, Doherty GA (2013) 'Keeping the Bowel Regular: The Emerging Role of Treg as a Therapeutic Target in Inflammatory Bowel Disease'. Inflammatory Bowel Diseases, . [DOI] [Details]
Burke JP, Doherty GA, O'Connell PR (2013) 'A survey of current practices used to maintain surgically induced remission following intestinal resection for Crohn's disease'. Colorectal Disease, . [DOI] [Details]
Kavanagh DO, Nolan B, Judge C, Hyland JM, Mulcahy HE, O'Connell PR, Winter DC, Doherty GA (2013) 'A Comparative Study of Short- and Medium-term Outcomes Comparing Emergent Surgery and Stenting as a Bridge to Surgery in Patients With Acute Malignant Colonic Obstruction'. Diseases of the Colon and Rectum, 56 (4):433-440. [DOI] [Details]
Blumenstein I, McDermott E, Keegan D, Byrne K, Ellison M, Doherty G, Schröder O, Mulcahy H (2013) 'Sources of information and factual knowledge in Europeans with inflammatory bowel diseases: A cross-cultural comparison between German and Irish patients'. Journal of Crohn's and Colitis, . [DOI] [Details]
Cullen G, Donnellan F, Doherty GA, Smith M, Cheifetz AS (2013) 'Evaluation of the small bowel in inflammatory bowel disease'. Expert Review of Gastroenterology and Hepatology, 7 (3):239-251. [DOI] [Details]
Cummins EP, Doherty GA, Taylor CT (2013) 'Hydroxylases as therapeutic targets in inflammatory bowel disease'. Laboratory Investigation, . [DOI] [Details]
Kavanagh DO, Carter MC, Keegan D, Doherty G, Smith MJ, Hyland JM, Mulcahy H, Sheahan K, O' Connell PR, O' Donoghue DP, Winter DC (2013) 'Management of colorectal cancer in patients with inflammatory bowel disease'. Techniques in Coloproctology, . [DOI] [Details]
McDermott S, Kilcoyne A, Kingston C, Keegan D, Mulcahy HE, Doherty GA, Malone DE, Murphy SJ, Cheriyan DG, Slattery E (2013) 'Impact of magnetic resonance enterography in the management of small bowel Crohn's disease'. European Journal of Gastroenterology & Hepatology, . [DOI] [Details]
Keegan D, McDermott E, Byrne K, Moloney D, Doherty GA, Mulcahy HE (2012) 'Development, validation and clinical assessment of a short questionnaire to assess disease-related knowledge in inflammatory bowel disease patients'. Scandanavian Journal of Gastroenterology, . [DOI] [Details]
Doherty GA, Miksad RA, Cheifetz AS, Moss AC (2012) 'Comparative cost-effectiveness of strategies to prevent postoperative clinical recurrence of Crohn's disease'. Inflammatory Bowel Diseases, 18 (9):1608-1616. [DOI] [Details]
Vaughn BP, Doherty GA, Gautam S, Moss AC, Cheifetz AS (2012) 'Screening for tuberculosis and hepatitis B prior to the initiation of anti-tumor necrosis therapy'. Inflammatory Bowel Diseases, 18 (6):1057-1063. [DOI] [Details]
Heetun Z, Doherty GA (2012) 'Restoring the regulatory regime in IBD: do anti-TNF agents rescue Treg?'. Inflammatory Bowel Diseases, 18 (6):1186-1187. [DOI] [Details]
O'Toole A, Alakkari A, Keegan D, Doherty G, Mulcahy H, O'Donoghue D (2012) 'Primary sclerosing cholangitis and disease distribution in inflammatory bowel disease'. Clinical Gastroenterology and Hepatology, 10 (4):439-441. [DOI] [Details]
Doherty G, Moss AC (2012) '5-aminosalicylates to prevent relapse of Crohn's disease after surgery'. American Journal of Gastroenterology, 107 (3):1-8. [DOI] [Details]
McDermott E, Murphy S, Keegan D, O'Donoghue D, Mulcahy H, Doherty G (2012) 'Efficacy of Adalimumab as a long term maintenance therapy in ulcerative colitis'. Journal of Crohn's and Colitis, . [DOI] [Details]
Nanda K, Courtney W, Keegan D, Byrne K, Nolan B, O'Donoghue D, Mulcahy H, Doherty G (2012) 'Prolonged avoidance of repeat surgery with endoscopic balloon dilatation of anastomotic strictures in Crohn's disease'. Journal of Crohn's and Colitis, . [DOI] [Details]
McDermott E, Keegan D, Byrne K, Doherty GA, Mulcahy HE (2012) 'The Short Health Scale: A valid and reliable measure of health related quality of life in English speaking inflammatory bowel disease patients'. Journal of Crohn's and Colitis, . [DOI] [Details]
Doherty GA, Bai A, Hanidziar D, Longhi MS, Lawlor GO, Putheti P, Csizmadia E, Nowak M, Cheifetz AS, Moss AC, Robson SC (2012) 'CD73 is a phenotypic marker of effector memory Th17 cells in inflammatory bowel disease'. European Journal of Immunology, 42 (11):3062-3072. [DOI] [Details]
GA Doherty, DG Cheriyan, JE Leyden, JF O'Dowd, FE Murray, SE Patchett (2011) 'Inter-endoscopist agreement in diagnosis of Barrett's oesophagus'. Gastroenterology, Frontline gastroenterol (2):162-167. [DOI] [Details]
McNicholas S, Andrews C, Boland K, Shields M, Doherty GA, Murray FE, Smyth EG, Humphreys H, Fitzpatrick F (2011) 'Delayed acute hospital discharge and healthcare-associated infection: the forgotten risk factor'. Journal of Hospital Infection, 78 (2):157-158. [DOI] [Details]
Leyden JE, Doherty GA, Hanley A, McNamara DA, Shields C, Leader M, Murray FE, Patchett SE, Harewood GC (2011) 'Quality of colonoscopy performance among gastroenterology and surgical trainees: a need for common training standards for all trainees?'. Endoscopy, 43 (11):935-940. [DOI] [Details]
Doherty GA, Moss AC, Cheifetz AS (2011) 'Capsule endoscopy for small-bowel evaluation in Crohn's disease'. Gastrointestinal Endoscopy, 74 (1):167-175. [DOI] [Details]
Doherty GA, Moss AC, Cheifetz AS (2010) 'Capsule endoscopy in suspected Crohn's disease: yield does not equal diagnosis'. American Journal of Gastroenterology, 105 (9):1-2. [DOI] [Details]
Doherty GA, Bennett GC, Cheifetz AS, Moss AC (2010) 'Meta-analysis: targeting the intestinal microbiota in prophylaxis for post-operative Crohn's disease'. Alimentary Pharmacology & Therapeutics, 31 (8):802-809. [DOI] [Details]
Doherty G, Kalachand R, Patchett S (2010) 'Adalimumab as therapy for fistulizing orofacial Crohn's disease'. Inflammatory Bowel Diseases, 16 (2):184-185. [DOI] [Details]
Doherty GA, Cannon MD, Lynch KM, Ayoubi KZ, Harewood GC, Patchett SE, Murray FE (2010) 'Co-prescription of gastro-protectants in hospitalized patients: an analysis of what we do and what we think we do'. Journal of Clinical Gastroenterology, 44 (3):1-6. [DOI] [Details]
Doherty G, Walsh P, Sheridan J, Kevans D, Keegan D, Nolan B, White A, McDermott E, Sheahan K, O'Shea D, Hyland J, O'Donoghue D, O'Sullivan J, Mulcahy H (2010) 'Clinical and pathological factors associated with colorectal cancer at the upper extreme of life'. Journal of the American Geriatrics Society, 58 (4):794-795. [DOI] [Details]
Doherty, G. A.,Byrne, S. M.,Molloy, E. S.,Malhotra, V.,Austin, S. C.,Kay, E. W.,Murray, F. E.,Fitzgerald, D. J.; (2009) 'Proneoplastic effects of PGE2 mediated by EP4 receptor in colorectal cancer'. BMC Cancer, 9 :207207. Available Online [Details]
Doherty GA, Byrne SM, Austin SC, Scully GM, Sadlier DM, Neilan TG, Kay EW, Murray FE, Fitzgerald DJ (2009) 'Regulation of the apoptosis-inducing kinase DRAK2 by cyclooxygenase-2 in colorectal cancer'. British Journal of Cancer, 101 (3):483-491. [DOI] [Details]
Molloy ES, Morgan MP, Doherty GA, McDonnell B, O'Byrne J, Fitzgerald DJ, McCarthy GM (2009) 'Microsomal prostaglandin E2 synthase 1 expression in basic calcium phosphate crystal-stimulated fibroblasts: role of prostaglandin E2 and the EP4 receptor'. Osteoarthritis and Cartilage, 17 (5):686-692. [DOI] [Details]
Doherty GA, Peppercorn MA (2009) 'Update on the role of modified release mesalamine in the management of ulcerative colitis and Crohn's disease'. Clinical and Experimental Gastroenterology, 2 :139-147. [Details]
Doherty GA, Murray FE (2009) 'Cyclooxygenase as a target for chemoprevention in colorectal cancer: lost cause or a concept coming of age?'. Expert Opinion on Therapeutic Targets, 13 (2):209-218. [DOI] [Details]
Doherty GA, Cheifetz AS (2009) 'Targeting TNF in postoperative recurrence of Crohn's disease: can we extinguish the fire before it starts?'. Inflammatory Bowel Diseases, 15 (12):1925-1926. [DOI] [Details]
Doherty GA, Cheifetz AS (2009) 'Management of acute severe ulcerative colitis'. Expert Review of Gastroenterology and Hepatology, 3 (4):395-405. [DOI] [Details]
Doherty G, Bennett G, Patil S, Cheifetz A, Moss AC (2009) 'Interventions for prevention of post-operative recurrence of Crohn's disease'. The Cochrane database of systematic reviews, (4). [DOI] [Details]
Molloy ES, Morgan MP, Doherty GA, McDonnell B, O'Byrne J, Fitzgerald DJ, McCarthy GM (2008) 'Mechanism of basic calcium phosphate crystal-stimulated matrix metalloproteinase-13 expression by osteoarthritic synovial fibroblasts: inhibition by prostaglandin E2'. Annals of the Rheumatic Diseases, 67 (12):1773-1779. [DOI] [Details]
Molloy ES, Morgan MP, Doherty GA, McDonnell B, Hilliard M, O'Byrne J, Fitzgerald DJ, McCarthy GM (2008) 'Mechanism of basic calcium phosphate crystal-stimulated cyclo-oxygenase-1 up-regulation in osteoarthritic synovial fibroblasts'. Journal of Rheumatology, 47 (7):965-971. [DOI] [Details]
Cryan LM, Paraoan L, Hiscott P, Damato BE, Grierson I, Gray D, Farrell M, Doherty GA, Fitzgerald DJ, O'Brien C. (2008) 'Expression of COX-2 and prognostic outcome in uveal melanoma'. Current Eye Research, 33 (2):177-184. [DOI] [Details]
Neilan, T. G.,Doherty, G. A.,Chen, G.,Deflandre, C.,McAllister, H.,Butler, R. K.,McClelland, S. E.,Kay, E.,Ballou, L. R.,Fitzgerald, D. J.; (2006) 'Disruption of COX-2 modulates gene expression and the cardiac injury response to doxorubicin'. American Journal of Physiology-Heart and Circulatory Ph, 291 (2):H532-6. [Details]


Sheridan J, Doherty GA Editorial: gut selective immunosuppression-is it a double edged sword?. Editorial [DOI] [Details]


Doherty, GA,Byrne, SM,Austin, SC,Scully, GM,Neilan, TG,Kay, EW,Murray, FE,Fitzgerald, DJ (2005) A mechanism for cyclooxygenase-2 mediated regulation of apoptosis in colorectal cancer cells; The role of DRAK2, a death associated protein kinase. Abstract [Details]


Hartery K, O'Reilly S;Houlihan D;Doherty G;Mulcahy H;Cullen G;Sheridan J Letter: vedolizumab for the management of inflammatory bowel disease in patients after liver transplantation for primary sclerosing cholangitis. LETTER [DOI] [Details]
Gibson DJ, Doherty GA (2015) Fecal Infliximab Loss. LETTER [DOI] [Details]


Research Interests

My research interests are in the role of innate and adaptive immunity in inflammatory bowel disease (ulcerative colitis and Crohns Disease) and in the importance of the host immune response in gastro-intestinal neoplasia, particularly Colorectal Cancer and Barretts Oesophagus. With my colleagues at the Centre for Colorectal Disease at SVUH/UCD we have an established track record in clinical research on a range of digestive disorders and are actively involved in clinical trials in IBD and Cancer.

Research Projects

Sponsor : European Chron's and Colitis Organisation (ECCO)
Title : Strategies for restoring loss of response to anti-TNF therapy in inflammatory bowel disease
Start Date / End Date : 01-JUL-16 / 30-JUN-17
Sponsor : Merck Sharp & Dohme (Ireland)
Title : Golimumab (GLM) dose Optimisation to Adequate Levels to Achieve Response in Colitis (GOAL-ARC)
Start Date / End Date : 11-NOV-15 / 10-NOV-18
Sponsor : University College Dublin Foundation Ltd.
Title : INITIative IBD research network 2016 - Glen Doherty - School of Medicine
Start Date / End Date : 12-SEP-16 / 11-SEP-18
Sponsor : University College Dublin Foundation Ltd.
Title : UCD Foundation support for a TopMed 10 fellow
Start Date / End Date : 24-NOV-16 / 31-MAR-20
Sponsor : University College Dublin Foundation Ltd.
Title : UCD Foundation award - Prof Glen Doherty - School of Medicine
Start Date / End Date : 01-OCT-16 / 30-SEP-18
Sponsor : University College Dublin Foundation Ltd.
Title : UCD Foundation award - Dr GDoherty- School of Medicine
Start Date / End Date : 01-APR-16 / 31-MAR-19
Sponsor : University College Dublin Foundation Ltd.
Title : UCD Foundation award - Prof Glen Doherty - School of Medicine
Start Date / End Date : 25-AUG-16 / 24-AUG-18
Sponsor : University College Dublin Foundation Ltd.
Title : Dansac Laker Newman Fellowship
Start Date / End Date : 01-JUL-15 / 20-AUG-18
Sponsor : Enterprise Ireland (EI)
Title : GREEN LIGHT: Assessment of the diagnostic commercial potential of a breath ammonia measurement system - giving AmBeR® the green light
Start Date / End Date : 01-OCT-15 / 31-AUG-16
Sponsor : University College Dublin Foundation Ltd.
Title : Research Activities
Start Date / End Date : 05-JAN-15 / 30-AUG-16
Sponsor : University College Dublin Foundation Ltd.
Title : Research activities of Dr Glen Doherty in the UCD School of Medicine and Medical Science
Start Date / End Date : 09-MAR-15 / 08-MAR-17
Sponsor : University College Dublin Foundation Ltd.
Title : INITIAtive Network support
Start Date / End Date : 01-AUG-15 / 31-JUL-17
Sponsor : University College Dublin Foundation Ltd.
Title : Merck Serono Newman Fellowship in Medical Oncology
Start Date / End Date : 10-JUL-15 / 31-JAN-18
Sponsor : University College Dublin Foundation Ltd.
Title : Donation towards Colorectal Disease
Start Date / End Date : 01-JAN-11 / 31-DEC-17
Sponsor : University College Dublin Foundation Ltd.
Title : UCD Foundation Award in Colorectal Disease
Start Date / End Date : 31-JUL-12 / 19-MAR-16
Sponsor : University College Dublin Foundation Ltd.
Title : SVUH IBD Clinical Research Programme
Start Date / End Date : 01-JUN-13 / 12-APR-15
Sponsor : Health Research Board (HRB)
Title : Understanding the link between molecular and microenvironmental influence on immunity in colorectal cancer
Start Date / End Date : 07-OCT-13 / 19-MAY-17
Sponsor : University College Dublin Foundation Ltd.
Title : The role of intestinal immunity in IBD and cancer
Start Date / End Date : 01-FEB-14 / 23-NOV-18
Sponsor : University College Dublin Foundation Ltd.
Title : Abbott Newman Fellowship in Inflammatory Bowel Disease
Start Date / End Date : 09-JUL-12 / 30-NOV-14

Current Postgraduate Students

Margaret Walshe, Medicine (MD)   -   Thesis Supervisor


Internal Collaborators

Prof Walter Kolch, SBI & Conway Institute
Prof Guenther Eissner,  SBI & Conway Institute
Prof Cormac Taylor, UCD SMMS & Conway Institute 
Dr Jan Leyden, GI Unit MMUH
Prof Donal O'Shea, UCD SMMS & Department of Endocrinology SVUH
Prof Dermot Malone, UCD SMMS & Department of Radiology SVUH
Dr Stephen Skehan, UCD SMMS & Department of Radiology SVUH
Dr Aoife Lally, UCD SMMS & Department of Dermatology SVUH

External Collaborators

Prof Simon Robson, BIDMC & Harvard University, Boston, MA
Prof Fergus Shanahan, UCC & APC, Cork 
Dr Alan Moss,  BIDMC & Harvard University, Boston, MA
Dr Adam Cheifetz, BIDMC & Harvard University, Boston, MA
Dr Eithne McMahon, Guys and Thomas, King's College London 
Dr Jean Fletcher, Department of Immunology, Trinity College Dublin
Dr Emma Creagh, Depatment of Immunology, Trinity College Dublin
Prof Jochen Prehn, RCSI 
Prof Larry Egan, NUI Galway 
Dr David Kevans, St James's/TCD
Dr Jane McCarthy, UCC