Navigation

Researchers at UCD

researcher

Hilary Cassidy

Post Doc Research Fellow Lvl I

School Of Medicine

Tel:
Email: hilary.cassidy@ucd.ie

Biography

For my undergraduate studies I completed a BSc Toxicology in Athlone Institute of Technology and subsequently a BSc Biochemistry and Biotechnology from Dublin Institute of Technology. I spent two years working in Uppsala university researching viral microRNA expression by HPV16. This led me to undertake a PhD in Pharmacology and Toxicology under the supervision of Dr Tara McMorrow and Prof. Michael Ryan (School of Biomoloecular and Biomedical Science, Conway Institute, UCD). My PhD focused on the identification of novel urinary biomarkers of chronic allograft nephropathy and employed in vitro studies and clinical samples, proteomics and metabolomics to identify novel biomarkers for disease onset and progression.

Following on from this I was awarded the Baxter Newman Fellowship, which focused on the identification of novel protein and micrRNA biomarkers of diabetic kidney disease (diabetic nephropathy), both in vitro and in a diabetic nephropathy clinical urinary cohort.  
 


I joined SBI in as a postdoctoral researcher in 2016, under the supervision of David Gomez. My work is part of the exciting SmartNanoTox project, a horizon 2020 project which focuses determining the toxicity of inhaled nanoparticles and establishing a system for classing new nanoparticles based on their ability to produce the pathway-relevant key event. My particular role in the project is the identification of composition of the protein corona of each nanoparticle through mass spectrometry. It is thought that the composition of this "protein cloak" is central to the overall toxicity of a nanoparticle and it is hoped that by gaining a more in-depth understanding of the protein content of this corona we can  identify properties of concern for new nanomaterials, thus helping to reduce the need for blanket toxicity testing and extensive animal testing in the future.

Publications

 

Book Chapters

Slattery C, Cassidy H, Johnston O, Ryan MP and McMorrow T (2012) 'Mechanisms of calcineurin inhibitor nephrotoxicity in chronic allograft injury' In: Slattery C, Cassidy H, Johnston O, Ryan MP and McMorrow T (eds). Chronic Kidney Disease and Renal Transplantation. India: Research Signpost. [Details]
 

Peer Reviewed Journals

H Cassidy, O Johnston, L Brennan, A O Riordan, P Conlon, MP Ryan, T Mc Morrow ; (2010) 'Metabolomic Analysis of Human(HOMO SAPIENS) Immunosuppressant Nephropathy Post Renal Transplantation'. IRISH J MED SCI, 7 :S283. [Details]
Johnston, O,Cassidy, H,O'Connell, S,O'Riordan, A,Gallagher, W,Maguire, PB,Wynne, K,Cagney, G,Ryan, MP,Conlon, PJ,McMorrow, T; (2011) 'Identification of beta 2-microglobulin as a urinary biomarker for chronic allograft nephropathy using proteomic methods'. Proteomics Clinical Applications, 5 :422-431. [DOI] [Details]
Cassidy H, Radford R, Slyne J, O'Connell S, Slattery C, Ryan MP, McMorrow T (2012) 'The role of MAPK in drug-induced kidney injury'. Signal Transduction, 2012 . [DOI] [Details]
H. Cassidy, J.Slyne, H. Frain, C. Slattery , M.P. Ryan, T. McMorrow * (2013) 'High-Throughput Proteomic Approaches to the Elucidation of Potential'. Proteome science, 1 (2):159-179. [Details]
Cassidy H, Slyne J, O'Kelly P, Traynor C, Conlon PJ, Johnston O, Slattery C, Ryan MP, McMorrow T (2015) 'Urinary biomarkers of chronic allograft nephropathy'. Proteomics - Clinical Applications, 9 (5-6):574-585. [DOI] [Details]
Bennett J, Cassidy H, Slattery C, Ryan MP, McMorrow T. (2016) 'Tacrolimus Modulates TGF-β Signaling to Induce Epithelial-Mesenchymal Transition in Human Renal Proximal Tubule Epithelial Cells'. Clinical Medicine, 5 (5):50-58. [Details]
 

Conference Publications

H. Cassidy, O. Johnston, L. Brennan, A. O'Riordan, P. Conlon, M.P. Ryan and T. McMorrow ; (2010) Metabolomic Analysis in Immunosuppressant Nephropathy Irish Nephrological Society Conference, Dublin, Ireland [Details]
H. Cassidy, O. Johnston, L. Brennan, A. O'Riordan, P. Conlon, M.P. Ryan and T. McMorrow ; (2010) Metabolomic Analysis of Human Immunosuppressant Nephropathy Post Renal Transplantation . In: Irish Journal of Medical Science eds. Proceedings of the Royal Academy of Medicine in Ireland Dublin, Ireland, , pp.179 [Details]
Cassidy H, Slyne J, Johnston O, Brennan L, O'Riordan A, Conlon P, Ryan MP, McMorrow T (2011) Metabolomic Profiling Of Chronic Allograft Nephropathy (CAN) Resulting From Immunosuppressant Therapies In Post Renal Transplantation Patients HUPO 10th World Congress Geneva, Switzerland, , 03-SEP-11 - 07-SEP-11 [Details]
                       

Abstract

Cassidy, H,Johnston, O,Brennan, L,Riordan, AO,Conlon, P,Mc Morrow, T,Ryan, MP (2010) METABOLOMIC ANALYSIS OF HUMAN (HOMO SAPIENS) IMMUNOSUPRESSANT NEPHROPATHY POST RENAL TRANSPLANTATION. Abstract [Details]