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Researchers at UCD

Katherine Howell

Lecturer

School Of Medicine
Conway Institute
Belfield
Dublin 4

Tel: +353 1 7166730
Email: katherine.howell@ucd.ie

Biography

Research is directed towards expanding our knowledge of the pathogenesis of chronic lung diseases, particularly the role of the pulmonary vasculature. Specifically we are interested in the potential therapeutic role of Erythropoietin in the treatment of emphysema and the role of Placental Growth factor in hypoxic lung disease.

BSc Physiology programme co-ordinator, Head of Teaching and Learning Physiology. Teaching Fellow, UCD. 

Professional

 

Associations

Association: American Thoracic Society, Function/Role: Member
     

Conference Contributions

Howell, K., Costello, C., McLoughlin, P.; Hypoxia and Lung Disease Conference. [Poster Presentation], European Respiratory Society, Taormina, Sicily .
Nichol, A., Howell, K., Costello, C. & McLoughlin, P.; Hypoxia Conference. [Poster Presentation], Keystone Symposium, Breckenridge, Colorado, USA .
Howell K, Giles J, McLoughlin P.; Irish Symposium. [Poster Presentation], Microscopical Society, Belfast, Ireland .
Howell, K., Preston, R., Fleming, L. and McLoughlin, P.; UK Symposium. [Poster Presentation], Physiological Society, Bristol .
Howell K, Preston, R., Fleming, L. and McLoughlin, P.; Irish Symposium. [Poster Presentation], Irish Thoracic Society, Cavan, Ireland .
Howell, K., Preston, RJ., and McLoughlin, P.; International Symposium. [Poster Presentation], American Thoracic Society (ATS), San Diego .
Howell, K., Preston, RJ., and McLoughlin, P.; International Symposium. [Poster Presentation], ATS, Orlando .
Howell, K., Ooi, H. and McLoughlin, P.; International Symposium. [Poster Presentation], Internation Union of Physiological Society, Christchurch, New Zealand .
Nichol, A., Howell, K. and McLoughlin, P.; (2005) Membrane Channels. [Poster Presentation], Physiological Society, Oxford , 05-SEP-05 - 07-SEP-05.
Howell, K, Preston, R., Fleming L. and McLoughlin, P. ; (2004) International Symposium. [Poster Presentation], ATS, Atlanta , 05-JUL-04 - 08-JUL-04.
   

Education

Year 2002 Institution: University College Dublin
Qualification: PhD Subject:
Year 1994 Institution: University of Sunderland
Qualification: BSc Subject:
         

Publications

     

Peer Reviewed Journals

Li L, Howell K;Sands M;Banahan M;Frohlich S;Rowan SC;Neary R;Ryan D;McLoughlin P (2013) 'The alpha and delta isoforms of CREB1 are required to maintain normal pulmonary vascular resistance'. PLoS ONE, 8 (12):e80637. [DOI] [Details]
Cahill E, Costello CM, Rowan SC, Harkin S, Howell K, Leonard MO, Southwood M, Cummins EP, Fitzpatrick SF, Taylor CT, Morrell NW, Martin F, McLoughlin P; (2012) 'Gremlin plays a key role in the pathogenesis of pulmonary hypertension'. Circulation, . Available Online [Details]
Cahill E, Rowan SC, Sands M, Banahan M, Ryan D, Howell K, McLoughlin P; (2012) 'The pathophysiological basis of chronic hypoxic pulmonary hypertension in the mouse: vasoconstrictor and structural mechanisms contribute equally'. Experimental Physiology, 97 (6):796-806. [DOI] [Details]
Costello CM, McCullagh B, Howell K, Sands M, Belperio JA, Keane MP, Gaine S, McLoughlin P.; (2011) 'A role for the CXCL12 receptor, CXCR7, in the pathogenesis of human pulmonary vascular disease'. European Respiratory Journal, . [Details]
Sands, M,Howell, K,Costello, CM,McLoughlin, P; (2011) 'Placenta growth factor and vascular endothelial growth factor B expression in the hypoxic lung'. Respiratory research, 12 . [DOI] [Details]
Fitzpatrick, SF,Tambuwala, MM,Bruning, U,Schaible, B,Scholz, CC,Byrne, A,O'Connor, A,Gallagher, WM,Lenihan, CR,Garvey, JF,Howell, K,Fallon, PG,Cummins, EP,Taylor, CT; (2011) 'An Intact Canonical NF-kappa B Pathway Is Required for Inflammatory Gene Expression in Response to Hypoxia'. Journal of Immunology, 186 :1091-1096. [DOI] [Details]
Howell, K.,Costello, C. M.,Sands, M.,Dooley, I.,McLoughlin, P.; (2009) 'L-Arginine promotes angiogenesis in the chronically hypoxic lung: a novel mechanism ameliorating pulmonary hypertension'. Am J Physiol Lung Cell Mol Physiol, 296 (66). Available Online [Details]
Nichol, AD,O'Cronin, DF,Howell, K,Naughton, F,O'Brien, S,Boylan, J,O'Connor, C,O'Toole, D,Laffey, JG,McLoughlin, P; (2009) 'Infection-induced lung injury is worsened after renal buffering of hypercapnic acidosis'. Critical Care Medicine, 37 :2953-2961. [DOI] [Details]
Leonard MO, Howell K, Madden SF, Costello CM, Higgins DG, Taylor CT, McLoughlin P; (2008) 'Hypoxia selectively activates the CREB family of transcription factors in the in vivo lung'. American Journal of Respiratory and Critical Care Medicine, . [Details]
Costello, CM,Howell, K,Cahill, E,McBryan, J,Konigshoff, M,Eickelberg, O,Gaine, S,Martin, F,McLoughlin, P; (2008) 'Lung-selective gene responses to alveolar hypoxia: potential role for the bone morphogenetic antagonist gremlin in pulmonary hypertension'. American Journal of Physiology-Lung Cellular and Molecular Physiology, 295 :272-284. [DOI] [Details]
Taylor CT, Leonard MO, Kieran NE, Howell K, Burne MJ, Varadarajan R, Dhakshinamoorthy S, Porter AG, O'farrelly C, Rabb H, ; (2006) 'Reoxygenation-specific activation of the antioxidant transcription factor Nrf2 mediates cytoprotective gene expression in ischemia-reperfusion injury'. FASEB Journal, 20 (NA):2624-2626. [DOI] [Details]
McLoughlin P, Hyvelin JM, Howell K.; (2005) 'Pulmonary hypertension'. New England Journal of Medicine, 352 (4):418-419. [Details]
Hyvelin JM, Howell K, Nichol A, Costello CM, Preston RJ, McLoughlin P.; (2005) 'Inhibition of Rho-kinase attenuates hypoxia-induced angiogenesis in the pulmonary circulation'. Circulation Research, 97 (2):185-191. [Details]
Shortt, AJ; Howell, K; O'Brien, C; McLoughlin, P; ; (2004) 'Chronic systemic hypoxia causes intra-retinal angiogenesis'. Journal of Anatomy, 205 (5):349-356. [Details]
McLoughlin P, Howell K, Ooi H, Preston R, ; (2004) 'Structural basis of hypoxic pulmonary hypertension: the modifying effect of chronic hypercapnia'. Experimental Physiology, 89 (1):66-72. [Details]
Kirwan, C; Howell, K; O'Brien, CO; McLoughlin, P; ; (2004) 'The role of nitric oxide in angiogenesisin the globally hypoxic retina'. Investigative Ophthalmology Visual Science, 45 (NA):739-739. [Details]
Howell, K; Preston, RJ; McLoughlin, P; ; (2003) 'Chronic hypoxia causes angiogenesis in addition to remodelling in the adult rat pulmonary circulation'. Journal of Physiology-London, 547 (1):133-145. [Details]
Howell, K; Hopkins, N; McLoughlin, P; ; (2002) 'Combined confocal microscopy and stereology: a highly efficient and unbiased approach to quantitative structural measurement in tissues'. Experimental Physiology, 87 (6):747-756. [Details]
Ooi, H, Cadogan, E, Sweeney, M, Howell, K, O'Regan, RG, McLoughlin, P, ; (2000) 'Chronic hypercapnia inhibits hypoxic pulmonary vascular remodeling'. American Journal of Physiology - Heart and Circulatory Physiology, 278 (2):331-338. [Details]
 

Conference Publications

Cahill E, Costello CM, Howell K, Southwood M, Leonard, M.O., Morrell NW, McLoughlin P; (2010) Lung-Selective Hypoxia-Induced Secretion of the BMP Antagonist Gremlin in Pulmonary Hypertension Keystone Symposium [Details]
Costello, CM, Howell K, Doherty S, Martin, F, Belperio J, Keane MP, Gaine, S, McLoughlin, P; (2010) CXCL12 signalling in hypoxic pulmonary hypertension American Thoracic Society International Conference [Details]
Coyle-Rowan S, Cahill E, Harkin S, Costello CM, Howell K, Martin F, McLoughlin P; (2010) Hypoxic upregulation of the BMP antagonist gremlin1 contributes to the development of pulmonary hypertension Physiological Society Main Meeting (2010), Birmingham; Proc Physiol Soc 20, PC06 Available Online [Details]
Cahill E, Costello CM, Howell K, Harkin S, Leonard MO, Southwood M, Morrell NW, McLoughlin P; (2010) Novel Autocrine Function of the BMP Antagonist Gremlin: a Key Role in Hypoxic Pulmonary Hypertension American Thoracic Society International Conference 2010 [Details]
Cahill E, Costello CM, Howell K, Leonard MO, Southwood M, Morrell NW, McLoughlin P; (2009) Hypoxic Upregulation of the BMP Antagonist Gremlin Blocks BMP Signalling in Pulmonary Endothelial Cells European Respiratory Society Lung Biology Meeting [Details]
Cahill E, Costello CM, Howell K, Leonard MO, Southwood M, Morrell NW, McLoughlin P; (2009) Hypoxic Upregulation of the BMP Antagonist Gremlin Blocks BMP Signalling in Pulmonary Endothelial Cells Physiological Society Annual Meeting [Details]
Costello, CM, Howell K, Brennan D, Doherty S, Martin, F, Gaine, S, McLoughlin, P; (2009) Potential selective role for CXCR7/CXCL12 signalling in the lung in response to hypoxic stress European Respiratory Society Lung Biology Meeting [Details]
Costello CM, Howell K, Doherty S, Martin F, Belperio J, Keane M, Gaine, S, McLoughlin, P; (2009) Potential selective role for CXCR7/CXCL12 signalling in the lung in response to hypoxic stress Physiological Society Annual General Meeting [Details]
Nichol, A., Howell, K., Costello, C. McLoughlin, P.; (2006) Reversal of vasoconstriction in chronically hypoxic hypertensive lungs does not alter the alveolar arterial oxygen gap Keystone Conferrnce [Details]
Nichol, A., Howell, K. Mc Loughlin, P.; (2005) Reversal of vasoconstriction in chronically hypoxic hypertensive lungs does not alter the alveolar arterial oxygen gap Physiological Society Smooth Muscle Symposium [Details]
Howell, K,Hopkins, N,McLoughlin, P (2002) EXPERIMENTAL PHYSIOLOGY Combined confocal microscopy and stereology: a highly efficient and unbiased approach to quantitative structural measurement in tissues , pp.747-756 [Details]
Howell, K, Ooi, H, Giles, J, McLoughlin, P, ; (2000) JOURNAL OF PHYSIOLOGY-LONDON Chronic hypoxia increases alveolar capillary endothelial surface area in adult rats , pp.294-295 [Details]
                                                                                         

Research

Research Interests

Research Projects

Sponsor : University College Dublin (UCD)
Title : Elucidating the protective effect of non-haematopoietic Erythropoietin mimetic ARA-290 in emphysema
Start Date / End Date : 01-MAY-12 / 31-MAY-14
Sponsor : University College Dublin (UCD)
Title : Placental Growth Factor knockout mice demonstrate elevated pulmonary hypertension and vessel leak
Start Date / End Date : 01-MAY-12 / 31-OCT-13
Sponsor : Science Foundation Ireland (SFI)
Title : Elucidating the the potential therapuetic role of Erythropoietin in the treatment of Emphysema
Start Date / End Date : 01-APR-13 / 01-APR-17
Sponsor : University College Dublin (UCD)
Title : Development of a bio-bank of primary human small airway epithelial cells from patients
Start Date / End Date : 01-APR-15 / 30-SEP-16
Sponsor : University College Dublin (UCD)
Title : Elucidating the role of Placental Growth Factor in Mediating Hypoxia-Induced Pulmonary Angiogenesis & Co-ordinated Epithelial Growth in the Adult Hypoxic Lung
Start Date / End Date : 01-OCT-08 / 30-SEP-11
Sponsor : Health Research Board (HRB)
Title : Elucidating the role of placental growth factor in mediating hypoxia-induced pulmonary angiogenesis and co-ordinated epithelial growth in the adult hypoxic lung
Start Date / End Date : 01-OCT-08 / 30-SEP-12
Sponsor : University College Dublin (UCD)
Title : Acquisition of bone-marrow transplantation technique to elucidate the role of bone-marrow derived endothelial progenitor cells
Start Date / End Date : 04-JAN-07 / 20-DEC-07