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Kevin Byrne

Research Scientist

School Of Medicine
Conway Institute
Belfield
Dublin 4

Tel: +353 1 7166834
Email: kevin.byrne@ucd.ie

Biography

(2013-present) Research Scientist, Conway Institute, School of Medicine, UCD
(2006-2013) Research Fellow, Smurfit Institute of Genetics, TCD 

 

(2007) PhD, Genome Evolution, TCD
(2002) MSc, Elementary Particle Theory, TCD
(1999) BA(Mod), Theoretical Physics, TCD

Professional

               

Education

Year 2007 Institution: Trinity College Dublin
Qualification: PhD Subject: Genome Evolution (Thesis Title: Post-Polyploidy Evolution in Yeasts)
Year 2002 Institution: Trinity College Dublin
Qualification: MSc Subject: Elementary Particle Theory (Thesis Title: Single spin asymmetry for proton-carbon scattering)
Year 1999 Institution: Trinity College Dublin
Qualification: BA (Mod) Subject: Theoretical Physics
     

Journals Edited

Nature Protocols: Reviewer.
Yeast: Reviewer.
Journal Of Molecular Evolution: Reviewer.
Plos Computational Biology: Reviewer.
Plos One: Reviewer.
Bmc Genomics: Reviewer.
Genome Biology And Evolution: Reviewer.
Molecular Biology And Evolution: Reviewer.
 

Publications

     

Peer Reviewed Journals

Ortiz-Merino RA, Kuanyshev N, Byrne KP, Varela JA, Morrissey JP, Porro D, Wolfe KH, Branduardi P (2018) 'Transcriptional response to lactic acid stress in the hybrid yeast Zygosaccharomyces parabailii'. Applied and Environmental Microbiology, . [Details]
Ortiz-Merino RA, Kuanyshev N, Braun-Galleani S, Byrne KP, Porro D, Branduardi P, Wolfe KH (2017) 'Evolutionary restoration of fertility in an interspecies hybrid yeast, by whole-genome duplication after a failed mating-type switch'. PLoS Biology, 15 :e2002128. [Details]
Hanson SJ, Byrne KP, Wolfe KH (2017) 'Flip/flop mating-type switching in the methylotrophic yeast Ogataea polymorpha is regulated by an Efg1-Rme1-Ste12 pathway'. PLoS Genetics, 13 :e1007092. [Details]
Coughlan AY, Hanson SJ, Byrne KP and Wolfe KH (2016) 'Centromeres of the yeast Komagataella phaffii (Pichia pastoris) have a simple inverted-repeat structure'. Genome Biology and Evolution, 8 :2482-2492. [Details]
Wolfe KH, Armisen D, Proux-Wera E, OhEigeartaigh SS, Azam H, Gordon JL, Byrne KP (2015) 'Clade- and species-specific features of genome evolution in the Saccharomycetaceae'. FEMS Yeast Research, 15 (5). [DOI] [Details]
OhEigeartaigh SS, Armisen D, Byrne KP, Wolfe KH (2014) 'SearchDOGS bacteria, software that provides automated identification of potentially missed genes in annotated bacterial genomes'. Journal of Bacteriology, 196 (11):2030-2042. [DOI] [Details]
Hanson SJ, Byrne KP, Wolfe KH (2014) 'Mating-type switching by chromosomal inversion in methylotrophic yeasts suggests an origin for the three-locus Saccharomyces cerevisiae system'. Proceedings of the National Academy of Sciences of the United States of America, 111 (45):1-8. [DOI] [Details]
Proux-Wera E, Byrne KP, Wolfe KH (2013) 'Evolutionary mobility of the ribosomal DNA array in yeasts'. Genome Biology and Evolution, 5 (3):525-531. [Details]
Kevin Byrne and Eoin O'Malley (2013) 'What's in a name? Using surnames as data for party research'. Party Politics, 19 :985-997. [Details]
Kevin Byrne and Eoin O'Malley (2013) 'The two types of Ulster unionism: Testing an ethnic explanation for the unionist/loyalist divide'. Irish Political Studies, 28 :130-139. [Details]
Maguire SL, Ohéigeartaigh SS, Byrne KP, Schröder MS, O'Gaora P, Wolfe KH, Butler G (2013) 'Comparative Genome Analysis and Gene Finding in Candida Species Using CGOB'. Molecular Biology and Evolution, 30 (6):1281-1291. [DOI] Link to full text [Details]
Proux-Wera E, Armisen D, Byrne KP, Wolfe KH (2012) 'A pipeline for automated annotation of yeast genome sequences by a conserved-synteny approach'. BMC Bioinformatics, 13 :237. [Details]
Kevin Byrne and Eoin O'Malley (2012) 'Politics with Hidden Bases: Unearthing the deep roots of party systems'. The British Journal of Politics and International Relations, 14 :613-629. [Details]
Gordon JL, Armisen D, Proux-Wera E, OhEigeartaigh SS, Byrne KP, Wolfe KH (2011) 'Evolutionary erosion of yeast sex chromosomes by mating-type switching accidents'. Proceedings of the National Academy of Sciences of the United States of America, 108 (50):20024-20029. [Details]
OhEigeartaigh SS, Armisen D, Byrne KP, Wolfe KH (2011) 'Systematic discovery of unannotated genes in 11 yeast species using a database of orthologous genomic segments'. BMC Genomics, 12 :377. [Details]
Gordon JL, Byrne KP, Wolfe KH (2011) 'Mechanisms of chromosome number evolution in yeast'. PLoS Genetics, 7 :e1002190. [Details]
Fitzpatrick DA, O'Gaora P, Byrne KP, Butler G (2010) 'Analysis of gene evolution and metabolic pathways using the Candida Gene Order Browser'. BMC Genomics, 11 :290-303. [DOI] [Details]
Gordon JL, Byrne KP, Wolfe KH (2009) 'Additions, losses, and rearrangements on the evolutionary route from a reconstructed ancestor to the modern Saccharomyces cerevisiae genome'. PLoS Genetics, 5 (5):e1000485. [Details]
Scannell DR, Frank AC, Conant GC, Byrne KP, Woolfit M, Wolfe KH (2007) 'Independent sorting-out of thousands of duplicated gene pairs in two yeast species descended from a whole-genome duplication'. Proceedings of the National Academy of Sciences of the United States of America, 104 (20):8397-8402. [Details]
Byrne KP, Wolfe KH (2007) 'Consistent patterns of rate asymmetry and gene loss indicate widespread neofunctionalization of yeast genes after whole-genome duplication'. Genetics, 175 (3):1341-1350. [Details]
Scannell DR*, Byrne KP*, Gordon JL, Wong S, Wolfe KH (2006) 'Multiple rounds of speciation associated with reciprocal gene loss in polyploid yeasts'. Nature, 440 (7082):341-345. [Details]
Byrne KP, Blanc G (2006) 'Computational analyses of ancient polyploidy'. Current Bioinformatics, 1 (2):131-146. [Details]
Fares MA, Byrne KP, Wolfe KH (2006) 'Rate asymmetry after genome duplication causes substantial long-branch attraction artifacts in the phylogeny of Saccharomyces species'. Molecular Biology and Evolution, 23 (2):245-253. [Details]
Byrne KP, Wolfe KH (2006) 'Visualizing syntenic relationships among the hemiascomycetes with the Yeast Gene Order Browser'. Nucleic Acids Research, 34 (Database issue):D452-455. [Details]
Byrne KP, Wolfe KH (2005) 'The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species'. Genome Research, 15 (10):1456-1461. [DOI] [Details]
                                                                                                                                           

Research

Research Interests

Dr Byrne's work focuses on studying genome evolution in model organisms using bioinformatics approaches. Species of particular interest have been the Saccharomycetaceae and methylotrophic yeasts, which are important systems for basic science and commercial biotechnology. High throughput analysis of genomic data, the development of visualisation and analysis platforms and both genome sequencing and transcriptomics are used to examine various aspects of the evolution of chromosome structure, gene order relationships and mating.
 

UCD Medicine Research Centre: Bioinformatics