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Researchers at UCD

researcher

Lorraine Kyne

Consultant/Senior Lecturer

School Of Medicine
Mater Hospital
Eccles Street
Dublin 7

Tel: 7164527
Email: lkyne@mater.ie

Publications

     

Peer Reviewed Journals

Kyne, L., Merry, C., O'Connell, B., O'Neill, D., Keane, C., Sanderson, P.J., Al-Shafi, K.M. (1996) 'Diagnostic value of Clostridium difficile cytotoxin assay [1]'. Journal of Hospital Infection, 32 (3):237-238. Available Online [DOI] [Details]
McCormack, G., Morrison, C., O'Morain, C., Kyne, L., O'Neill, D., O'Reilly, F.M., O'Loughlin, S., Murphy, G.M., Kiely, J.L., McCabe, M., McNicholas, W.T., Hayes, F., Sheahan, K., McKenna, T.J. (1996) 'Royal Academy of Medicine in Ireland section of medicine - Proceedings of meeting held October 1994'. Irish Journal of Medical Science, 165 (1):61-62. Available Online [DOI] [Details]
Kyne, L., Moran, A., Keane, C., O'Neill, D. (1998) 'Hospital-acquired diarrhoea in elderly patients: Epidemiology and staff awareness'. Age and Ageing, 27 (3):339-343. Available Online [DOI] [Details]
Kyne, L., Merry, C., O'Connell, B., Keane, C., O'Neill, D. (1998) 'Community-acquired Clostridium difficile infection'. Journal of Infection, 36 (3):287-288. Available Online [DOI] [Details]
Synnott, K., Mealy, K., Merry, C., Kyne, L., Keane, C., Quill, R. (1998) 'Timing of surgery for fulminating pseudomembranous colitis'. British Journal of Surgery, 85 (2):229-231. Available Online [DOI] [Details]
Kyne, L., Kelly, C.P. (1998) 'Prospects for a vaccine for Clostridium difficile'. BioDrugs, 10 (3):173-181. Available Online [DOI] [Details]
Kyne, L., Merry, C., O'Connell, B., Harrington, P., Keane, C., O'Neill, D. (1998) 'Simultaneous outbreaks of two strains of toxigenic Clostridium difficile in a general hospital'. Journal of Hospital Infection, 38 (2):101-112. Available Online [DOI] [Details]
Kyne, L., Merry, C., O'Connell, B., Kelly, A., Keane, C., O'Neill, D. (1999) 'Factors associated with prolonged symptoms and severe disease due to Clostridium difficile'. Age and Ageing, 28 (2):107-113. Available Online [DOI] [Details]
Keller, M.J., Hausdorff, J.M., Kyne, L., Wei, J.Y. (1999) 'Is age a negative prognostic indicator in HIV infection or AIDS?'. Aging Clinical and Experimental Research, 11 (1):35-38. Available Online [Details]
Kyne, L., Hausdorff, J.M., Knight, E., Dukas, L., Azhar, G., Wei, J.Y. (2000) 'Neutrophilia and congestive heart failure after acute myocardial infarction'. American Heart Journal, 139 (1 I):94-100. Available Online [Details]
Kyne, L., Warny, M., Qamar, A., Kelly, C.P. (2000) 'Asymptomatic carriage of Clostridium difficile and serum levels of IgG antibody against toxin A'. New England Journal of Medicine, 342 (6):390-397. Available Online [DOI] [Details]
Kyne, L., Farrell, R.J., Kelly, C.P. (2001) 'Clostridium difficile'. Gastroenterology Clinics of North America, 30 (3):753-777. Available Online [Details]
Kyne, L., Kelly, C.P. (2001) 'Recurrent Clostridium difficile diarrhoea'. Gut, 49 (1):152-153. Available Online [DOI] [Details]
Kyne, L., Warny, M., Qamar, A., Kelly, C.P. (2001) 'Association between antibody response to toxin A and protection against recurrent Clostridium difficile diarrhoea'. Lancet, 357 (9251):189-193. Available Online [DOI] [Details]
Kyne, L., Hamel, M.B., Polavaram, R., Kelly, C.P. (2002) 'Health care costs and mortality associated with nosocomial diarrhea due to Clostridium difficile'. Clinical Infectious Diseases, 34 (3):346-353. Available Online [DOI] [Details]
Kyne, L., Sougioultzis, S., McFarland, L.V., Kelly, C.P. (2002) 'Underlying disease severity as a major risk factor for nosocomial Clostridium difficile diarrhea'. Infection Control and Hospital Epidemiology, 23 (11):653-659. Available Online [Details]
Aboudola, S., Kotloff, K.L., Kyne, L., Warny, M., Kelly, E.C., Sougioultzis, S., Giannasca, P.J., Monath, T.P., Kelly, C.P. (2003) 'Clostridium difficile vaccine and serum immunoglobulin G antibody response to toxin A'. Infection and Immunity, 71 (3):1608-1610. Available Online [DOI] [Details]
Drudy, D., Calabi, E., Kyne, L., Sougioultzis, S., Kelly, E., Fairweather, N., Kelly, C.P. (2004) 'Human antibody response to surface layer proteins in Clostridium difficile infection'. FEMS Immunology and Medical Microbiology, 41 (3):237-242. Available Online [DOI] [Details]
Sougioultzis, S., Kyne, L., Drudy, D., Keates, S., Maroo, S., Pothoulakis, C., Giannasca, P.J., Lee, C.K., Warny, M., Monath, T.P., Kelly, C.P. (2005) 'Clostridium difficile toxoid vaccine in recurrent C. difficile-associated diarrhea'. Gastroenterology, 128 (3):764-770. Available Online [DOI] [Details]
Drudy, D., Quinn, T., O'Mahony, R., Kyne, L., ÿ'Gaora, P., Fanning, S. (2006) 'High-level resistance to moxifloxacin and gatifloxacin associated with a novel mutation in gyrB in toxin-A-negative, toxin-B-positive Clostridium difficile'. Journal of Antimicrobial Chemotherapy, 58 (6):1264-1267. Available Online [DOI] [Details]
Drudy, D., Harnedy, N., Fanning, S., Hannan, M., Kyne, L. (2007) 'Emergence and control of fluoroquinolone-resistant, toxin A-negative, toxin B-positive Clostridium difficile'. Infection Control and Hospital Epidemiology, 28 (8):932-940. Available Online [DOI] [Details]
Long, S., Fenelon, L., Fitzgerald, S., Nolan, N., Burns, K., Hannan, M., Kyne, L., Fanning, S., Drudy, D. (2007) 'First isolation and report of clusters of Clostridium difficile PCR 027 cases in Ireland'. Euro surveillance : bulletin européen sur les maladies transmissibles=European communicable disease bulletin, 12 (4):E070426.3. Available Online [Details]
Hu, M.Y., Maroo, S., Kyne, L., Cloud, J., Tummala, S., Katchar, K., Dreisbach, V., Noddin, L., Kelly, C.P. (2008) 'A Prospective Study of Risk Factors and Historical Trends in Metronidazole Failure for Clostridium difficile Infection'. Clinical Gastroenterology and Hepatology, 6 (12):1354-1360. Available Online [DOI] [Details]
Drudy, D., Goorhuis, B., Bakker, D., Kyne, L., Van Den Berg, R., Fenelon, L., Fanning, S., Kuijper, E.J. (2008) 'Clindamycin-resistant clone of Clostridium difficile PCR ribotype 027, Europe'. Emerging Infectious Diseases, 14 (9):1485-1487. Available Online [DOI] [Details]
Hannon N, Sheehan O;Kelly L;Marnane M;Merwick A;Moore A;Kyne L;Duggan J;Moroney J;McCormack PM;Daly L;Fitz-Simon N;Harris D;Horgan G;Williams EB;Furie KL;Kelly PJ (2009) 'Stroke associated with atrial fibrillation--incidence and early outcomes in the north Dublin population stroke study'. Cerebrovascular Diseases, 29 (1):43-49. [DOI] [Details]
Hu, M.Y., Katchar, K., Kyne, L., Maroo, S., Tummala, S., Dreisbach, V., Xu, H., Leffler, D.A., Kelly, C.P. (2009) 'Prospective Derivation and Validation of a Clinical Prediction Rule for Recurrent Clostridium difficile Infection'. Gastroenterology, 136 (4):1206-1214. Available Online [DOI] [Details]
Sheehan OC, Merwick A;Kelly LA;Hannon N;Marnane M;Kyne L;McCormack PM;Duggan J;Moore A;Moroney J;Daly L;Harris D;Horgan G;Kelly PJ (2009) 'Diagnostic usefulness of the ABCD2 score to distinguish transient ischemic attack and minor ischemic stroke from noncerebrovascular events: the North Dublin TIA Study'. Stroke, 40 (11):3449-3454. [DOI] [Details]
Kyne, L. (2010) 'Clostridium difficile - Beyond antibiotics'. New England Journal of Medicine, 362 (3):264-265. Available Online [DOI] [Details]
Marnane, M., Duggan, C.A., Sheehan, O.C., Merwick, A., Hannon, N., Curtin, D., Harris, D., Williams, E.B., Horgan, G., Kyne, L., McCormack, P.M.E., Duggan, J., Moore, A., Crispino-O'Connell, G., Kelly, P.J. (2010) 'Stroke subtype classification to mechanism-specific and undetermined categories by TOAST, A-S-C-O, and causative classification system: Direct comparison in the north Dublin population stroke study'. Stroke, 41 (8):1579-1586. Available Online [DOI] [Details]
O'Donoghue, C., Kyne, L. (2010) 'Update on Clostridium difficile infection'. Current Opinion in Gastroenterology, . Available Online [DOI] [Details]
Burns, K., Skally, M., Solomon, K., Scott, L., McDermott, S., O'Flanagan, D., Fanning, S., Kyne, L., Fenelon, L., Fitzpatrick, F. (2010) 'Clostridium difficile infection in the Republic of Ireland: Results of a 1-month national surveillance and ribotyping project, March 2009'. Infection Control and Hospital Epidemiology, 31 (10):1085-1087. Available Online [DOI] [Details]
Sheehan OC, Kyne L;Kelly LA;Hannon N;Marnane M;Merwick A;McCormack PM;Duggan J;Moore A;Moroney J;Daly L;Harris D;Horgan G;Williams EB;Kelly PJ (2010) 'Population-based study of ABCD2 score, carotid stenosis, and atrial fibrillation for early stroke prediction after transient ischemic attack: the North Dublin TIA study'. Stroke, 41 (5):844-850. [DOI] [Details]
Ní Chróinín, D., Syed Farooq, S.F., Burke, M., Kyne, L. (2011) 'Patient understanding of discharge diagnoses: Prevalence and predictors'. European Geriatric Medicine, 2 (2):74-78. Available Online [DOI] [Details]
Chróinín, D.N., Callaly, E.L., Duggan, J., Merwick, A., Hannon, N., Sheehan, Q., Marnane, M., Horgan, G., Williams, E.B., Harris, D., Kyne, L., McCormack, P.M.E., Moroney, J., Grant, T., Williams, D., Daly, L., Kelly, P.J. (2011) 'Association between acute statin therapy, survival, and improved functional outcome after ischemic stroke: The North Dublin population stroke study'. Stroke, 42 (4):1021-1029. Available Online [DOI] [Details]
Ní Chróinín, D., Haslam, R., Blake, C., Ryan, K., Kyne, L., Power, D. (2011) 'Death in long-term care facilities: Attitudes and reactions of patients and staff. A qualitative study'. European Geriatric Medicine, 2 (1):56-59. Available Online [DOI] [Details]
Marnane, M., Chroinin, D.N., Callaly, E., Sheehan, O.C., Merwick, A., Hannon, N., Horgan, G., Kyne, L., Moroney, J., McCormack, P.M.E., Dolan, E., Duggan, J., Williams, D., Crispino-O'Connell, G., Kelly, P.J. (2011) 'Stroke recurrence within the time window recommended for carotid endarterectomy'. Neurology, 77 (8):738-743. Available Online [DOI] [Details]
Kelly, C.P., Kyne, L. (2011) 'The host immune response to Clostridium difficile'. Journal of Medical Microbiology, 60 (8):1070-1079. Available Online [DOI] [Details]
Hannon, N., Callaly, E., Moore, A., Ní Chróinín, D., Sheehan, O., Marnane, M., Merwick, A., Kyne, L., Duggan, J., McCormack, P.M.E., Dolan, E., Crispino-O'Connell, G., Harris, D., Horgan, G., Williams, D., Kelly, P.J. (2011) 'Improved late survival and disability after stroke with therapeutic anticoagulation for atrial fibrillation: A population study'. Stroke, 42 (9):2503-2508. Available Online [DOI] [Details]
Ní Chróinín, D., Kyne, L., Duggan, J., Last, J., Molphy, A., O'Shea, D., Steele, M., Bury, G., Cullen, W. (2012) 'Medicine in the community: A unique partnership'. Clinical Teacher, 9 (3):158-163. Available Online [DOI] [Details]
O'Donoghue, C., Iversen, C., Duggan, J., Power, D., Fanning, S., Kyne, L. (2012) 'Polypharmacy is an independent risk factor for oropharyngeal isolation of gram-negative bacilli in older persons'. Journal of the American Geriatrics Society, 60 (1):182-183. Available Online [DOI] [Details]
Kelly, P.J., Crispino, G., Sheehan, O., Kelly, L., Marnane, M., Merwick, A., Hannon, N., Ní Chróinín, D., Callaly, E., Harris, D., Horgan, G., Williams, E.B., Duggan, J., Kyne, L., McCormack, P., Dolan, E., Williams, D., Moroney, J., Kelleher, C., Daly, L. (2012) 'Incidence, event rates, and early outcome of stroke in Dublin, Ireland: The north dublin population stroke study'. Stroke, 43 (8):2042-2047. Available Online [DOI] [Details]
Callaly E, Ni Chroinin D;Hannon N;Marnane M;Akijian L;Sheehan O;Merwick A;Hayden D;Horgan G;Duggan J;Murphy S;O'Rourke K;Dolan E;Williams D;Kyne L;Kelly PJ (2015) 'Rates, Predictors, and Outcomes of Early and Late Recurrence After Stroke: The North Dublin Population Stroke Study'. Stroke, 47 (1):244-246. [DOI] [Details]
Hayden, D.T., Hannon, N., Callaly, E., Ní Chróinín, D., Horgan, G., Kyne, L., Duggan, J., Dolan, E., O'Rourke, K., Williams, D., Murphy, S., Kelly, P.J. (2015) 'Rates and determinants of 5-year outcomes after atrial fibrillation-related stroke: A population study'. Stroke, 46 (12):3488-3493. Available Online [DOI] [Details]
Callaly, E.L., Ni Chroinin, D., Hannon, N., Sheehan, O., Marnane, M., Merwick, A., Kelly, L.A., Horgan, G., Williams, E., Harris, D., Williams, D., Moore, A., Dolan, E., Murphy, S., Kelly, P.J., Duggan, J., Kyne, L. (2015) 'Falls and fractures 2 years after acute stroke: The North Dublin Population Stroke Study'. Age and Ageing, 44 (5):882-886. Available Online [DOI] [Details]
O'Donoghue, C., Solomon, K., Fenelon, L., Fitzpatrick, F., Kyne, L. (2016) 'Effect of proton pump inhibitors and antibiotics on the gut microbiome of hospitalised older persons'. Journal of Infection, 72 (4):498-500. Available Online [DOI] [Details]
Osuafor CN, Kyne L (2016) 'Assessment of response to cerebrospinal fluid tap test for normal pressure hydrocephalus: how we do it'. BMJ Case Reports, 2016 . [DOI] [Details]
Na X, Martin AJ;Sethi S;Kyne L;Garey KW;Flores SW;Hu M;Shah DN;Shields K;Leffler DA;Kelly CP (2015) 'A Multi-Center Prospective Derivation and Validation of a Clinical Prediction Tool for Severe Clostridium difficile Infection'. PLoS ONE, 10 (4). [DOI] [Details]
Hannon N, Daly L;Murphy S;Smith S;Hayden D;N¿¿ Chr¿¿in¿¿n D;Callaly E;Horgan G;Sheehan O;Honari B;Duggan J;Kyne L;Dolan E;Williams D;Wiley M;Kelly PJ (2014) 'Acute hospital, community, and indirect costs of stroke associated with atrial fibrillation: population-based study'. Stroke, 45 (12):3670-3674. [DOI] [Details]
Moore P, Kyne L;Martin A;Solomon K (2013) 'Germination efficiency of clinical Clostridium difficile spores and correlation with ribotype, disease severity and therapy failure'. Journal of Medical Microbiology, 62 (Pt 9):1405-1413. [DOI] [Details]
N¿¿ Chr¿¿in¿¿n D, Cronin E;Cullen W;O'Shea D;Steele M;Bury G;Kyne L (2013) 'Would you be a geriatrician? Student career preferences and attitudes to a career in geriatric medicine'. Age and Ageing, 42 (5):654-657. [DOI] [Details]
Solomon K, Martin AJ;O'Donoghue C;Chen X;Fenelon L;Fanning S;Kelly CP;Kyne L (2013) 'Mortality in patients with Clostridium difficile infection correlates with host pro-inflammatory and humoral immune responses'. Journal of Medical Microbiology, 62 (Pt 9):1453-1460. [DOI] [Details]
Solomon K, Murray S;Scott L;McDermott S;Drudy D;Martin A;O'Donoghue C;Skally M;Burns K;Fenelon L;Fitzpatrick F;Kyne L;Fanning S (2011) 'An investigation of the subtype diversity of clinical isolates of Irish Clostridium difficile ribotypes 027 and 078 by repetitive-extragenic palindromic PCR'. Journal of Medical Microbiology, 60 (Pt 8):1080-1087. [DOI] [Details]
Solomon K, Fanning S;McDermott S;Murray S;Scott L;Martin A;Skally M;Burns K;Kuijper E;Fitzpatrick F;Fenelon L;Kyne L (2011) 'PCR ribotype prevalence and molecular basis of macrolide-lincosamide-streptogramin B (MLSB) and fluoroquinolone resistance in Irish clinical Clostridium difficile isolates'. Journal of Antimicrobial Chemotherapy, 66 (9):1976-1982. [DOI] [Details]
Martin, A. J., Collins, C. J., Ruddy, R., Drudy, D., Hannan, M. M., Kyne, L., ; (2008) 'Simultaneous control of norovirus and Clostridium difficile outbreaks due to enhanced infection prevention and control measures'. Journal of Hospital Infection, 68 (2):180-181. [Details]
Wright, A., Drudy, D., Kyne, L., Brown, K., Fairweather, N. F., ; (2008) 'Immunoreactive cell wall proteins of Clostridium difficile identified by human sera'. Journal of Medical Microbiology, 57 (6):750-756. [Details]
Drudy, D, Fanning, S, Kyne, L, ; (2007) 'Toxin A-negative, toxin B-positive Clostridium difficile'. International Journal of Infectious Diseases, 11 (1):5-10. [Details]
Drudy, D, Kyne, L, OMahony, R, Fanning, S, ; (2007) 'gyrA mutations in fluoroquinolone-resistant Clostridium difficile PCR-027'. Emerging Infectious Diseases, 13 :504-505. [Details]
Drudy, D, Harnedy, N, Fanning, S, O'Mahony, R, Kyne, L, ; (2007) 'Isolation and characterisation of toxin A-negative, toxin B-positive Clostridium difficile in Dublin, Ireland'. Clinical Microbiology and Infection, 13 (3):298-304. [Details]
 

Conference Publications

Fogarty, F; Swan, D; Bury, G; Fealy, GM; Kyne, L; Meagher, D; Hannigan, A; Cullen, W (2016) Mental disorders in older adults: database study of 74,261 patients attending primary care Joint AUDGPI Annual Scientific Meeting / ICGP Annual Research Meeting [Details]
                                                                                         

Research

Research Interests

My main area of research is Clostridium difficile and healthcare-associated infections in older people. Together with a group of collaborators at UCD, the Mater Misericordiae and St Vincent¿s University hospitals, Beaumont hospital and the Health Protection Surveillance Centre (HPSC) our research has focussed on the epidemiology and the human immune response to C. difficile infection. Our work examines the host inflammatory response to C. difficile infection and outcome.  

Our recent research has involved an examination of the faecal microbiome and how it is affected by hospitalisation, diet, medications and frailty in individual patients.

As a member of a sub-committee of the Health Protection Surveillance Centre, I was involved in drawing up National Guidelines for the Surveillance, Diagnosis and Management of C. difficile Infection which were launched in 2008 and revised and published on-line in 2013.  I am also involved in other collaborative research on stroke, atrial fibrillation and medical education.