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Researchers at UCD

Madeline Murphy

School of Medicine

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Biography

Dr Murphy obtained her PhD from University College Dublin and has been leading a research group in the UCD Conway Institute since 2006. Her research focus is the identification and functional characterisation of novel therapeutic targets with the aim of developing improved diagnostics and therapeutics for fibrotic disease and more recently for cancer.  She has published extensively in peer reviewed scientific journals and received research grant income from Breast Cancer Campaign, Wellcome Trust, Science Foundation Ireland, Health Research Board and National Children's Research Centre.

Professional

         

Conference Contributions

Fair T, Murphy M, Martin F, Boland M.P, Lonergan P. (2002); (2002) Identification of differentially expressed genes in early and late cleaving bovine embryos using suppressive subtractive hybridisation. [Published Abstract], Theriogenology, * , 06-JAN-02 - 10-JAN-02.
Brazil, DP., Kattla, JJ., Moran, RM., Roxburgh SR., Murphy M., Hemmings BA., Godson, C.; European Association for the Study of Diabetes (EASD). [Poster Presentation], European Association for the Study of Diabetes (EASD), Athens, Greece .
   

Education

Year 1993 Institution: University College Dublin
Qualification: PhD Subject:
Year 1986 Institution: University College Dublin
Qualification: BSc Subject:
         

Publications

     

Peer Reviewed Journals

Beaton H, Andrews D;Parsons M;Murphy M;Gaffney A;Kavanagh D;McKay GJ;Maxwell AP;Taylor CT;Cummins EP;Godson C;Higgins DF;Murphy P;Crean J (2016) 'Wnt6 regulates epithelial cell differentiation and is dysregulated in renal fibrosis'. American journal of physiology. Renal physiology, . [DOI] [Details]
Weiner-Gorzel K, Dempsey E, Milewska M, McGoldrick A, Toh V, Walsh A, Lindsay S, Gubbins L, Cannon A, Sharpe D, O'Sullivan J, Murphy M, Madden SF, Kell M, McCann A, Furlong F (2015) 'Overexpression of the microRNA miR-433 promotes resistance to paclitaxel through the induction of cellular senescence in ovarian cancer cells'. Cancer medicine, 4 (5):745-758. [DOI] Link to full text [Details]
van den Hurk K, Balint B;Toomey S;O'Leary PC;Unwin L;Sheahan K;McDermott EW;Murphy I;van den Oord JJ;Rafferty M;FitzGerald DM;Moran J;Cummins R;MacEneaney O;Kay EW;O'Brien CP;Finn SP;Heffron CC;Murphy M;Yela R;Power DG;Regan PJ;McDermott CM;O'Keeffe A;Orosz Z;Donnellan PP;Crown JP;Hennessy BT;Gallagher WM (2015) 'High-throughput oncogene mutation profiling shows demographic differences in BRAF mutation rates among melanoma patients'. Melanoma Research, 25 (3):189-199. [DOI] [Details]
Docherty, N. G., Murphy, M., Martin, F., Brennan, E. P., Godson, C. (2014) 'Targeting cellular drivers and counter-regulators of hyperglycaemia- and transforming growth factor-beta1-associated profibrotic responses in diabetic kidney disease'. Experimental Physiology, 99 (9):1154-62. Available Online [Details]
Hickey FB, Corcoran JB;Griffin B;Bhreathnach U;Mortiboys H;Reid HM;Andrews D;Byrne S;Furlong F;Martin F;Godson C;Murphy M (2014) 'IHG-1 increases mitochondrial fusion and bioenergetic function'. Journal of Diabetes, 63 (12):4314-4325. [DOI] [Details]
Corcoran JB, McCarthy S, Griffin B, Gaffney A, Bhreathnach U, Börgeson E, Hickey FB, Docherty NG, Higgins DF, Furlong F, Martin F, Godson C, Murphy M (2013) 'IHG-1 must be localised to mitochondria to decrease Smad7 expression and amplify TGF-β1-induced fibrotic responses'. Biochimica et biophysica acta, 1833 (8):1969-1978. [DOI] [Details]
Brennan, EP,Nolan, KA,Borgeson, E,Gough, OS,McEvoy, CM,Docherty, NG,Higgins, DF,Murphy, M,Sadlier, DM,Ali-Shah, ST,Guiry, PJ,Savage, DA,Maxwell, AP,Martin, F,Godson, C (2013) 'Lipoxins Attenuate Renal Fibrosis by Inducing let-7c and Suppressing TGF beta R1'. Journal of the American Society of Nephrology : JASN, 24 :627-637. [DOI] [Details]
Murphy M, Hickey F, Godson C (2013) 'IHG-1 amplifies TGF-β1 signalling and mitochondrial biogenesis and is increased in diabetic kidney disease'. Current Opinion in Nephrology and Hypertension, 22 (1):77-84. [DOI] [Details]
Kelly NA, Murphy M, Giles S, Russell JD (2012) 'Subglottic injury: a clinically relevant animal model'. Laryngoscope, 122 (11):2574-2581. [DOI] [Details]
Rowan F, Coffey JC, Oʼconnell PR, Docherty NG, Murphy M, Murphy TB.; (2011) 'Ileal Pouch Microbial Diversity'. Annals of Surgery, . [Details]
Hickey, FB,Corcoran, JB,Docherty, NG,Griffin, B,Bhreathnach, U,Furlong, F,Martin, F,Godson, C,Murphy, M; (2011) 'IHG-1 Promotes Mitochondrial Biogenesis by Stabilizing PGC-1 alpha'. Journal of the American Society of Nephrology : JASN, 22 :1475-1485. [DOI] [Details]
Borgeson, E,Docherty, NG,Murphy, M,Rodgers, K,Ryan, A,O'Sullivan, TP,Guiry, PJ,Goldschmeding, R,Higgins, DF,Godson, C; (2011) 'Lipoxin A(4) and benzo-lipoxin A(4) attenuate experimental renal fibrosis'. FASEB Journal, 25 :2967-2979. [DOI] [Details]
Rowan, F,Docherty, NG,Murphy, M,Murphy, TB,Coffey, JC,O'Connell, PR; (2010) 'Bacterial Colonization of Colonic Crypt Mucous Gel and Disease Activity in Ulcerative Colitis'. Annals of Surgery, 252 :869-874. [DOI] [Details]
Rowan, F., Docherty, N. G., Murphy, M., Murphy, T. B., Coffey, J. C., O'Connell, P. R. (2010) 'Bacterial colonization of colonic crypt mucous gel and disease activity in ulcerative colitis'. Ann Surg, 252 (5):869-75. Available Online [Details]
Rowan, F., Docherty, N.G., Murphy, M., Murphy, T.B., Coffey, J.C. and O'Connell, P.R.; (2010) 'Desulfovibrio bacterial species are increased in ulcerative colitis'. Diseases of the Colon and Rectum, 53 (11):1530-1536. [DOI] [Details]
Rowan FE, Docherty NG, Coffey JC, Murphy M, Murphy B, O¿Connell PR; (2010) 'CULTURE INDEPENDENT QUANTIFICATION OF TOTAL BACTERIAL COLONIZATION OF COLONIC CRYPTS IN PATIENTS WITH ULCERATIVE COLITIS AND CONTROLS'. Annals of Surgery, . [Details]
Brennan EP, Ehrich M, Brazil DP, Crean JK, Murphy M, Sadlier DM, Martin F, Godson C, van den Boom D, Maxwell AP, Savage DA.; (2010) 'DNA methylation profiling in cell models of diabetic nephropathy'. Epigenetics : official journal of the DNA Methylation Society, 16 (5). [Details]
McKnight, AJ,Patterson, CC,Pettigrew, KA,Savage, DA,Kilner, J,Murphy, M,Sadlier, D,Maxwell, AP,Warren 3 UK Genetics Kidneys Diab; (2010) 'A GREM1 Gene Variant Associates with Diabetic Nephropathy'. Journal of the American Society of Nephrology : JASN, 21 :773-781. [DOI] [Details]
Hickey FB, Ryan A, Murphy M, Godson C, ; (2009) 'Diabetes mellitus and apoptosis: inflammatory cells'. Apoptosis, . [DOI] [Details]
Brennan, EP; Ehrich, M; Brazil, DP; Crean, JK; Murphy, M; Sadlier, DM; Martin, F; Godson, C; McKnight, AJ; Van den Boom, D; Maxwell, AP; Savage, DA (2009) 'Comparative analysis of DNA methylation profiles in peripheral blood leukocytes versus lymphoblastoid cell lines'. Epigenetics : official journal of the DNA Methylation Society, 4 (3):159-164. Available Online [Details]
O'Connell PR, Burke JP, Watson RW, Murphy M, Docherty NG, Coffey JC, ; (2009) 'Simvastatin impairs smad-3 phosphorylation and modulates transforming growth factor beta1-mediated activation of intestinal fibroblasts'. British Journal of Surgery, 5 (NA):541-551. [DOI] [Details]
Murphy, M,Docherty, NG,Griffin, B,Howlin, J,McArdle, E,McMahon, R,Schmid, H,Kretzler, M,Droguett, A,Mezzano, S,Brady, HR,Furlong, F,Godson, C,Martin, F; (2008) 'IHG-1 amplifies TGF-beta 1 signaling and is increased in renal fibrosis'. Journal of the American Society of Nephrology, 19 (NA):1672-1680. [DOI] [Details]
Godson C, Murphy M, Crean J, Brazil DP, Sadlier D, Martin F, ; (2008) 'Regulation and consequences of differential gene expression in diabetic kidney disease'. Biochemical Society Transactions, Pt 5 (NA):941-945. [DOI] [Details]
Furlong, F, Crean, J, Thornton, L, OLeary, R, Murphy, M, Martin, F, ; (2007) 'Dysregulated intracellular signaling impairs CTGF-stimulated responses in human mesangial cells exposed to high extracellular glucose'. American Journal of Physiology-Renal Physiology, 292 :1691-170. [DOI] [Details]
Watson RW, Healy DA, Daly PJ, Docherty NG, Murphy M, Fitzpatrick JM, ; (2006) 'Heat shock-induced protection of renal proximal tubular epithelial cells from cold storage and rewarming injury'. Journal of the American Society of Nephrology : JASN, 3 (NA):805-812. [DOI] [Details]
Lambe, T; Finlay, D; Murphy, M; Martin, F; ; (2006) 'Differential expression of connexin 43 in mouse mammary cells'. Cell Biology International, 30 (5):472-479. [Details]
Roxburgh, SA; Murphy, M; Pollock, CA; Brazil, DP; ; (2006) 'Recapitulation of embryological programmes in renal fibrosis - The importance of epithelial cell plasticity and developmental genes'. Nephron - Physiology, 103 (3):139-148. [Details]
Docherty, NG; O'Sullivan, OE; Healy, DA; Murphy, M; O'Neill, AJ; Fitzpatrick, JM; Watson, RWG; ; (2006) 'TGF-beta(1)-induced EMT can occur independently of its proapoptotic effects and is aided by EGF receptor activation'. American Journal of Physiology - Renal Physiology, 290 (5):1202-1212. [Details]
Dolan, V; Murphy, M; Kretzler, M; Mezzano, S; Brady, HR; ; (2006) 'Expression of gremlin in diabetic nephropathy in vivo and epithelial-mesenchymal transdifferentiation in vitro'. Scottish Medical Journal, 51 (1):54-55. [Details]
Docherty, N.G., O'Sullivan, O.E., Healy, D.A., Murphy, M., O'Neill, A.J., Fitzpatrick, J.M. Watson, R.W.G.; (2005) 'TGF-beta1-induced EMT can occur independently of it proapoptotic effects and is aided by EGF receptor activation'. Am J Phy Reanl Phy, :f1202-f1212. [Details]
Brady HR, Dolan V, Murphy M, Sadlier D, Lappin D, Doran P, Godson C, Martin F, O'Meara Y, Schmid H, Henger A, Kretzler M, Droguett A, Mezzano S, ; (2005) 'Expression of gremlin, a bone morphogenetic protein antagonist, in human diabetic nephropathy'. American Journal of Kidney Diseases, 45 (6):1034-1039. [Details]
Kirwan, RP, Leonard, MO, Murphy, M, Clark, AF, O'Brien, CJ, ; (2005) 'Transforming growth factor-beta-regulated gene transcription and protein expression in human GFAP-negative lamina cribrosa cells'. Glia, 52 (4):309-324. [Details]
Dolan, V; Murphy, M; Sadlier, D; Lappin, D; Doran, P; Godson, C; Martin, F; O'Meara, Y; Schmid, H; Henger, A; Kretzler, M; Droguett, A; Mezzano, S; Brady, HR; ; (2005) 'Expression of gremlin, a bone morphogenetic protein antagonist, in human diabetic nephropathy'. American Journal of Kidney Diseases, 45 (6):1034-1039. [Details]
Martin F, Crean JK, Furlong F, Finlay D, Mitchell D, Murphy M, Conway B, Brady HR, Godson C, ; (2004) 'Connective tissue growth factor [CTGF]/CCN2 stimulates mesangial cell migration through integrated dissolution of focal adhesion complexes and activation of cell polarization'. FASEB Journal, 13 (NA):1541-1543. [DOI] [Details]
Fair, T., Murphy, M., Rizos, D., Martin, F., Boland, M.P., Lonergan, P.; (2004) 'Analysis of differential maternal mRNA expression in developmentally competent and incompetent bovine 2-cell embryos'. Molecular Reproduction and Development, 67 (2):136-144. [Details]
Conway, B. R.,Maxwell, A. P.,Savage, D. A.,Patterson, C. C.,Doran, P. P.,Murphy, M.,Brady, H. R.,Fogarty, D. G.; (2004) 'Association between variation in the actin-binding gene caldesmon and diabetic nephropathy in type 1 diabetes'. Diabetes, 53 (4):1162-5. [Details]
Fair, T,Gutierrez-Adan, A,Murphy, M,Rizos, D,Martin, F,Boland, MP,Lonergan, P; (2004) 'Search for the bovine homolog of the murine Ped gene and characterization of its messenger RNA expression during bovine preimplantation development'. International Journal of Bifurcation and Chaos, 70 :488-494. [DOI] [Details]
Murphy, M; Curtin, D; Dolan, V; Hensey, C; Kretzler, M; Schlondorff, D; Godson, C; Brady, HR; Martin, F; ; (2003) 'IHG-1 enhances TGF-beta-induced transcriptional activation and its expression is increased in diabetic nephropathy'. Journal of the American Society of Nephrology : JASN, 14 (NA):127-128. [Details]
Crean, J; Finlay, B; Conway, B; Murphy, M; Godson, G; Brady, HR; Finian, M; ; (2003) 'CCN-2 (CTGF) induces actin rearrangement and mesangial cell motility: Involvement of RhoA and protein kinase C zeta'. Journal of the American Society of Nephrology : JASN, 14 (NA):129-129. [Details]
Dolan, V; Murphy, M; Alarcon, P; Brady, HR; Hensey, C; ; (2003) 'Gremlin - a putative pathogenic player in progressive renal disease'. Expert Opinion on Therapeutic Targets, 7 (4):523-526. [Details]
Madden, SF; Lappin, DWP; Murphy, MM; Martin, FM; Eikmans, M; De Heer, E; Baelde, H; Brady, HR; Doran, PP; ; (2002) 'Computational gene annotation in diabetic nephropathy'. Journal of the American Society of Nephrology : JASN, 13 (NA):118-118. [Details]
Lappin, DWP; McMahon, R; Murphy, M; Brady, HR; ; (2002) 'Gremlin: an example of the re-emergence of developmental programmes in diabetic nephropathy'. Nephrology Dialysis Transplantation, 17 (NA):65-67. [Details]
Murphy, M, McMahon, R., DWP Lappin, D.W.P. and Brady H.R. ; (2002) 'Gremlins: Is this what renal fibrogenesis has come to?'. Experimental Nephrology, 10 (4):241-244. [Details]
Clarkson, MR,Murphy, M,Gupta, S,Lambe, T,Mackenzie, HS,Godson, C,Martin, F,Brady, HR; (2002) 'High glucose-altered gene expression in mesangial cells - Actin-regulatory protein gene expression is triggered by oxidative stress and cytoskeletal disassembly'. Journal of Biological Chemistry, 277 :9707-9712. [DOI] [Details]
Crean, JKG; Finlay, D; Murphy, M; Moss, C; Godson, C; Martin, F; Brady, HR; ; (2002) 'The role of p42/44 MAPK and protein kinase B in connective tissue growth factor induced extracellular matrix protein production, cell migration, and actin cytoskeletal rearrangement in human mesangial cells'. Journal of Biological Chemistry, 277 (46):44187-44194. [Details]
McMahon, R; Murphy, M; Gardiner, C; Godson, C; Martin, F; Brady, HR; ; (2001) 'Gremlin inhibits DNA synthesis and proliferation in human mesangial cells by a BMP independent mechanism'. British Journal of Pharmacology, 134 (NA). [Details]
Maderna, P; Godson, C; Hannify, G; Murphy, M; Brady, HR; ; (2000) 'Influence of lipoxin A(4) and other lipoxygenase-derived eicosanoids on tissue factor expression'. American Journal of Physiology - Cell Physiology, 279 (4):945-953. [Details]
Murphy, M., Harte, T., McInerney, J. and Smith, T. ; (2000) 'Molecular cloning of atlantic salmon dinucleoside phosphate kinase and its pattern of expression during embryogenesis'. Gene, 257 (1):139-148. [Details]
McMahon, R; Murphy, M; Clarkson, M; Taal, M; Mackenzie, HS; Godson, C; Martin, F; Brady, HR; ; (2000) 'IHG-2, a mesangial cell gene induced by high glucose, is human gremlin - Regulation by extracellular glucose concentration, cyclic mechanical strain, and transforming growth factor-beta 1'. Journal of Biological Chemistry, 275 (14):9901-9904. [Details]
Clarkson, MR; Gupta, S; Murphy, M; Martin, F; Godson, C; Brady, HR; ; (1999) 'Connective tissue growth factor: a potential stimulus for glomerulosclerosis and tubulointerstitial fibrosis in progressive renal disease'. Current Opinion in Nephrology and Hypertension, 8 (5):543-548. [Details]
Murphy, M; Godson, C; Martin, F; Brady, HR; ; (1999) 'Gene expression in cultured human mesangial cells in response to extracellular glucose as assessed by suppressive subtractive hybridization'. Kidney International, 55 (6):2585-2585. [Details]
Murphy, M., Godson, C., Cannon, S., Kato, S., Mackenzie, H.S., Martin, F., Brady, H.R. ; (1999) 'Suppression subtraction hybridization identifies high glucose levels as a stimulus for expression of connective tissue growth factor and other genes in human mesangial cells'. Journal of Biological Chemistry, 274 :5830-5834. [Details]
Murphy, M; Godson, C; Cannon, S; Martin, F; Brady, HR; ; (1999) 'Connective tissue growth factor expression in human mesangial cells exposed to high glucose'. FASEB Journal, 13 (4):37-37. [Details]
Murphy, M; Godson, C; Cannon, S; Martin, F; Brady, HR; ; (1999) 'Connective tissue growth factor expression in human mesangial cells exposed to high glucose'. Kidney International, 55 (6):2585-2585. [Details]
Murphy, M; McGinty, A; Godson, C; ; (1998) 'Protein kinases C: potential targets for intervention in diabetic nephropathy'. Current Opinion in Nephrology and Hypertension, 7 (5):563-570. [Details]

Other Journals

Rowan F., Docherty N.G., Murphy M., Murphy T.B., Coffey J.C., O'Connell P.R. (2011) 'Ileal pouch microbial diversity' Annals of Surgery 254 (4) :669-670. [DOI] [Details]
Rowan, F., Docherty, N.G., Murphy, M., Murphy, T.B., Coffey, J.C. and O'Connell, P.R.; (2010) 'Desulfovibrio bacterial species are increased in ulcerative colitis' Diseases of the Colon and Rectum 53 (4) :541-541. [Details]
Roxburgh SA, Murphy M, Pollock CA, Brazil DP ; (2006) 'Recapitulation of Embryological Programmes in Renal Fibrosis - The Importance of Epithelial Cell Plasticity and Developmental Genes' Nephron Physiol 103 :139-148. [Details]
Roxburgh SA, Murphy M, Pollock CA, Brazil DP ; (2006) 'Recapitulation of Embryological Programmes in Renal Fibrosis - The Importance of Epithelial Cell Plasticity and Developmental Genes' Nephron Physiol 103 :139-148. [Details]
Roxburgh, S.A., Murphy, M., Pollock, C.A. & Brazil D.P.; (2005) 'Recapitulation of embryological programmes in renal fibrosis-the importance of epithelial cell plasticity and developmental genes' Nephron Physiology 103 :139-148. [Details]

Conference Publications

Kavanagh, D., Gaffney A., Murphy, M., Faherty, N., Andrews, D., Higgins, D., McKay, G., Maxwell, P., Godson, C. and Crean, J. (2012) Wnt 6 is increased in diabetic nephropathy and modulates de novo tubulogenesis and opposes TGFbeta mediated epithelial cell differentiation in vitro American Society of Nephrology [Details]
Rowan, F,Docherty, NG,Murphy, M,Murphy, B,Coffey, JC,O'Connell, PR (2010) DISEASES OF THE COLON & RECTUM Desulfovibrio Bacterial Species Are Increased in Ulcerative Colitis , pp.1530-1536 [DOI] [Details]
Burke, JP,Watson, RWG,Murphy, M,Docherty, NG,Coffey, JC,O'Connell, PR (2009) BRITISH JOURNAL OF SURGERY Simvastatin impairs smad-3 phosphorylation and modulates transforming growth factor beta 1-mediated activation of intestinal fibroblasts , pp.541-551 [DOI] [Details]
Murphy, M,Crean, J,Brazil, DP,Saidlier, D,Martin, F,Godson, C (2008) BIOCHEMICAL SOCIETY TRANSACTIONS Regulation and consequences of differential gene expression in diabetic kidney disease , pp.941-945 [DOI] [Details]
Crean J, Finlay B, Conway B, Murphy M, Godson G, Brady HR, Martin, F (2003) CCN-2 (CTGF) induces actin rearrangement and mesangial cell motility: Involvement of RhoA and protein kinase C zeta American Society of Nephrology [Details]
Lappin, DWP,McMahon, R,Murphy, M,Brady, HR (2002) NEPHROLOGY DIALYSIS TRANSPLANTATION Gremlin: an example of the re-emergence of developmental programmes in diabetic nephropathy , pp.65-67 [Details]
   

Editorial

Griffin B, Murphy M (2015) A Friend in Need: Activated Protein C Stabilizes YB-1 during Renal Ischemia Reperfusion Injury. Editorial [DOI] [Details]
                 

Abstract

Murphy, M,Jarboui, M,Schroeder, M,Gautier, VW (2011) FUNCTIONAL RELEVANCE OF THE HIV-1 TAT-DDX3 INTERACTION IN THE REGULATION OF HIV-1 GENE EXPRESSION. Abstract [Details]
O'Sullivan, J,Murphy, M,McMahon, HEM (2010) Characteristics of a New Microbial Protease that Degrades the Prion Protein. Abstract [Details]
Dolan, V,Murphy, M,Kretzler, M,Mezzano, S,Brady, HR (2006) Expression of gremlin in diabetic nephropathy in vivo and epithelial-mesenchymal transdifferentiation in vitro. Abstract [Details]
Murphy, M,Curtin, D,Dolan, V,Hensey, C,Kretzler, M,Schlondorff, D,Godson, C,Brady, HR,Martin, F (2003) IHG-1 enhances TGF-beta-induced transcriptional activation and its expression is increased in diabetic nephropathy. Abstract [Details]
Crean, J,Finlay, B,Conway, B,Murphy, M,Godson, G,Brady, HR,Finian, M (2003) CCN-2 (CTGF) induces actin rearrangement and mesangial cell motility: Involvement of RhoA and protein kinase C zeta. Abstract [Details]
McMahon, R,Murphy, M,Gardiner, C,Godson, C,Martin, F,Brady, HR (2001) Gremlin inhibits DNA synthesis and proliferation in human mesangial cells by a BMP independent mechanism. Abstract [Details]
Murphy, M,Godson, C,Cannon, S,Martin, F,Brady, HR (1999) Connective tissue growth factor expression in human mesangial cells exposed to high glucose. Abstract [Details]
Murphy, M,Godson, C,Martin, F,Brady, HR (1999) Gene expression in cultured human mesangial cells in response to extracellular glucose as assessed by suppressive subtractive hybridization. Abstract [Details]
       

Reviews

Murphy, M,Hickey, F,Godson, C (2013) IHG-1 amplifies TGF-beta 1 signalling and mitochondrial biogenesis and is increased in diabetic kidney disease. Reviews [DOI] [Details]
Ryan, A,Murphy, M,Godson, C,Hickey, FB (2009) Diabetes mellitus and apoptosis: inflammatory cells. Reviews [DOI] [Details]
Dolan, V,Murphy, M,Alarcon, P,Brady, HR,Hensey, C (2003) Gremlin - a putative pathogenic player in progressive renal disease. Reviews [Details]
Murphy, M,McMahon, R,Lappin, DWP,Brady, HR (2002) Gremlins: Is this what renal fibrogenesis has come to?. Reviews [Details]
Clarkson, MR,Gupta, S,Murphy, M,Martin, F,Godson, C,Brady, HR (1999) Connective tissue growth factor: a potential stimulus for glomerulosclerosis and tubulointerstitial fibrosis in progressive renal disease. Reviews [Details]
Murphy, M,McGinty, A,Godson, C (1998) Protein kinases C: potential targets for intervention in diabetic nephropathy. Reviews [Details]
                                                   

Letters

Rowan, F,Docherty, NG,Murphy, M,Murphy, TB,Coffey, JC,O'Connell, PR (2011) Ileal Pouch Microbial Diversity. Letters [DOI] [Details]

Research

Research Interests

My research focuses on molecular mechanisms of renal disease. I have identified a number of potential novel therapeutic targets (e.g. IHG-1, Gremlin, CTGF) that cause diabetic renal disease and use a combination of molecular, cellular, proteomic and bioinformatic analyses to characterise the function of these genes in kidney disease progression. My main research focus is the characterisation of a novel gene, IHG-1, which I identified in 1999 and which I have since shown to amplify TGFbeta-1 signalling reponses.  Interestingly, my group has shown that IHG-1 is a mitochondrial protein with important implications for the resolution of kidney disease. Current investigations include in vivo conditional deletion of IHG‐1 and development of dominant negative IHG-1 as a therapeutic. In collaboration with colleagues in the Conway Institute, we have begun investigating the role of IHG-1 in cancer progression. My group also studies gremlin regulation of profibrotic responses and mitomycin C modulation of subglottic stenosis.

Mitochondria play a central role in cellular adaptation to hyperglycaemic conditions in diabetes and in cancer cell survival. My group has identified and characterised novel mitochondrial protein IHG-1 and have shown that IHG-1 plays a pivotal role in maintaining mitochondrial quality. We are currently investigating the role of IHG-1 in diabetic kidney disease and in breast cancer in order to develop novel diagnostic and treatment strategies.

Research Projects

Sponsor : Science Foundation Ireland (SFI)
Title : Investigation of the role of mitochondrial associated IHG-1 in TGF-Beta signalling
Start Date / End Date : 01-JUL-06 / 31-DEC-09
Sponsor : The Wellcome Trust (WT)
Title : Characterisation of IHG-1, a novel diabetic-associated gene product, which amplifies TGF B-induced signalling
Start Date / End Date : 01-FEB-04 / 31-JAN-07
Sponsor : Southside Anaemia Co Ordinator Fund Ireland
Title : IHG-1 expression in kidney disease
Start Date / End Date : 01-OCT-06 / 30-SEP-09
Sponsor : Science Foundation Ireland (SFI)
Title : Novel Biomarkers for Early Diagnosis of Diabetic Nephropathy
Start Date / End Date : 01-JAN-14 / 31-MAR-15
Sponsor : Breast Cancer Campaign, UK
Title : To investigate the role of GRP78, IHG-1 and their interaction in relation to the Taxol® resistance phenotype in triple negative breast cancer (TNBC)
Start Date / End Date : 06-MAR-14 / 05-MAR-15
Sponsor : Health Research Board (HRB)
Title : Preventing chemotherapy resistance in triple negative breast cancer
Start Date / End Date : 01-OCT-14 / 30-SEP-17
Sponsor : The Wellcome Trust (WT)
Title : To investigate the use of HSPA5 as a biomarker for early diagnosis of Diabetic Nephropathy.
Start Date / End Date : 10-JUN-14 / 01-SEP-14
Sponsor : Science Foundation Ireland (SFI)
Title : 27th ANNUAL MEETING OF THE EUROPEAN RENAL CELL STUDY GROUP
Start Date / End Date : 01-NOV-14 / 30-APR-15
Sponsor : University College Dublin Foundation Ltd.
Title : Research Activities
Start Date / End Date : 25-NOV-14 / 24-NOV-15