Researchers at UCD

Marcus Butler

School of Medicine

Tel: +353 1 2214000


My main laboratory research interest is in chronic obstructive pulmonary disease (COPD), asthma and fibrogenic lung reactions and our group focuses on the role of circulating fibrocytes in smoking-related lung disease states including COPD and idiopathic pulmonary fibrosis (IPF). We are also active in clinical research of COPD and smoking-related interstitial fibrosis.


Honours and Awards

Year: 2003.
Title: Lemass Gold Medal from the Irish Association of Internal Medicine
Year: 2005.
Title: Best Basic Sciences Poster at Irish Thoracic Society Annual Scientific Meeting
Year: 2009.
Title: ATS Travel Award from the American Thoracic Society


Association: European Respiratory Society, Function/Role: Member
Association: Royal College of Physicians of Ireland, Function/Role: Fellow
Association: American Thoracic Society, Function/Role: Member
Association: Irish Thoracic Society, Function/Role: Member

Conference Contributions

M Pallin*, S Walsh*, MF O¿Driscoll, C Murray, A Cahalane, L Brown, M Carter, P Mitchell, TJ McDonnell, MW Butler (2012) Senior author: Overwhelming support among urban Irish COPD patients for lung cancer screening by low dose CT scan. [Oral Presentation], American Thoracic Society Annual International Scientific Conference, San Francisco, CA, USA , 18-MAY-12 - 23-MAY-12.
Butler MW, Hackett NR, Salit J, Strulovici-Barel Y, Crystal RG. ; (2010) Human Small Airway Epithelium Expression of Cystatin A is Modulated by Genetic Variation and Up-regulated in Chronic Obstructive Pulmonary Disease. [Oral Presentation], American Thoracic Society International Conference, New Orleans , 14-MAY-10 - 19-MAY-10.
Butler MW, Hackett NR, Salit J, Strulovici-Barel Y, Crystal RG; (2009) Copy Number Variation Polymorphisms modulate the gene expression levels of Glutathione S-transferase subtypes in human airway epithelium. [Oral Presentation], American Thoracic Society International Conference, San Diego , 15-MAY-09 - 20-MAY-09.


Committee : Irish Thoracic Society 2015
Committee : Irish Thoracic Society Annual Scinetific Meeting 2011
Committee : Irish Thoracic Society Annual Scientific Meeting 2010


Year 1997 Institution: University College Hospital, Galway
Qualification: MB, BCh, BAO Subject:
Year 2000 Institution: Royal College of Physicians UK
Qualification: MRCP Subject:
Year 2008 Institution: Royal Coll Surgeons in Ireland
Qualification: MD Subject:

Journals Edited

Respiratory Care: Reviewer.
Eur J Intern Med: Reviewer.
Advances In Therapy: Reviewer.
Int J Chron Obstruct Pulmon Dis: Reviewer.
Tohoku Journal Of Experimental Medicine: Reviewer.

Other Activities

Advances in Therapy. Editorial advisory board member



Book Chapters

Butler MW, Keane MP (2014) 'Bronchitis and Bronchiectasis' In: Cohen J, Powderly WG, Opal SM (eds). Infectious Diseases. Amsterdam: Elsevier. , pp.243-250 [Details]
Butler, M McLoughlin, P Keane, M (2015) 'Chemokines, Adipokines, and Growth Factors in the Lung' In: Grippi, M Elias, J Fishman, J Pack, A Senior, R Kotloff, R (eds). Fishman's Pulmonary Diseases and Disorders. Philadelphia: McGraw-Hill. Available Online [Details]
Butler MW, Keane MP (2017) 'The Role of Immunity & Inflammation in IPF Pathogenesis' In: Nathan SD, Meyer KC (eds). Idiopathic Pulmonary Fibrosis. New York: Springer Publishing Group. [Details]

Peer Reviewed Journals

O'Neill AC, McCarthy C, Ridge CA, Mitchell P, Hanrahan E, Butler M, Keane MP, Dodd JD; (2011) 'Rapid Needle-Out Patient-Rollover Time after Percutaneous CT-guided Transthoracic Biopsy of Lung Nodules: Effect on Pneumothorax Rate'. Radiology, . [DOI] [Details]
Mitchell PD, Salter BM, Oliveria JP, El-Gammal A, Tworek D, Smith SG, Sehmi R, Gauvreau GM, Butler M, O'Byrne PM (2016) 'Glucagon Like Peptide-1 receptor expression on human eosinophils and its regulation of eosinophil activation'. Clinical Experimental Allergy, . [DOI] [Details]
Khan F, Arimin M, Hogan AE, Kent BD, Eigenheer S, Corrigan MA, O¿Shea D, Butler MW (2017) 'Preliminary asthma-related outcomes following glucagon-like peptide 1 agonist therapy'. Qjm-An International Journal Of Medicine, . [Details]
Lavelle L, Brady D, McEvoy S, Murphy D, Gallagher A, Butler M, Shortt F, McMullen M, Fabre A, Lynch DA, Keane MP, Dodd JD (2017) 'Pulmonary Fibrosis: Tissue Characterization Imaging Using Late-enhanced MRI Thorax Compared to Non-contrast Anatomic HRCT Imaging'. Diagnostic and Interventional Radiology, . [DOI] [Details]
Mokoka MC, Lombard L, MacHale EM, Walsh J, Cushen B, Sulaiman I, Carthy DM, Boland F, Doyle F, Hunt E, Murphy DM, Faul J, Butler M, Hetherington K, Mark FitzGerald J, Boven JFV, Heaney LG, Reilly RB, Costello RW (2017) 'In patients with severe uncontrolled asthma, does knowledge of adherence and inhaler technique using electronic monitoring improve clinical decision making? A protocol for a randomised controlled trial'. BMJ Open, 7 (6):e015367. [DOI] [Details]
Mitchell PD, Das JP;Murphy DJ;Keane MP;Donnelly SC;Dodd JD;Butler MW (2015) 'Idiopathic pulmonary fibrosis with emphysema: evidence of synergy among emphysema and idiopathic pulmonary fibrosis in smokers'. Respiratory Care, 60 (2):259-268. [DOI] [Details]
Brady D, Lavelle LP, McEvoy SH, Murphy DJ, Gallagher A, Gibney B, Butler MW, Shortt F, McMullen M, Fabry A, Lynch D, Abbara S, Donnelly SC, Dodd JD (2015) 'Assessing Fibrosis in Pulmonary Sarcoidosis: Late-enhanced MRI Compared to Anatomic HRCT Imaging'. Qjm-An International Journal Of Medicine, . [Details]
Walsh SM, Gallagher A, Gallagher R, Barnes E, Doherty GA, Dodd JD, Butler MW (2015) 'First do no harm: nasogastric tube placement and confirmation'. Qjm-An International Journal Of Medicine, . [Details]
Judge EP, Abrahams J, Costigan D, McWeeney D, Healy D, Dodd J, Jeffers M, Butler M, Fabre A (2015) 'Pulmonary Nodular Lymphoid Hyperplasia presenting cavitating pulmonary nodules'. Pathology Research and Practice, . [Details]
Nicholson TT, Franciosi A;Landers S;Butler MW (2015) 'Assessing potential risks of treatment with long-term azithromycin in COPD patients: long-term oxygen users beware?'. Irish Journal of Medical Science, . [DOI] [Details]
Murphy O, King G, Callanan I, Butler MW. (2013) 'Why is your patient sedated?'. International Journal of Health Care Quality Assurance, 27 (4). [Details]
Daly C, Callanan I, Butler MW. (2013) 'Safety Comes First: Are Doctors Attentive Enough to their Initial Clinical Assessment Notes?'. Irish Medical Journal, . [Details]
Macken WL, Macken HC, Callanan I, Butler MW. (2013) 'Not written, not done: are we identifying elderly at-risk patients for pneumococcal vaccination?'. Irish Journal of Medical Science, . [Details]
Fearon C, Fabre A, Heffernan EJ, Skehan SJ, Swan N, Keane MP, Butler MW (2013) 'Metastatic chordoma detected by endobronchial ultrasound-guided transbronchial needle aspiration'. Journal of Thoracic Disease, 5 (1):90-93. [DOI] [Details]
McCarthy CJ, O'Neill AC, McEvoy SH, Kilcoyne A, Butler MW, Keane MP, Dodd JD (2012) 'Poststernotomy lymphadenopathy: prevalence, size, and location on chest CT'. Diagnostic and Interventional Radiology, . [DOI] [Details]
Pallin, M,Walsh, S,O'Driscoll, MF,Murray, C,Cahalane, A,Brown, L,Carter, M,Mitchell, P,McDonnell, TJ,Butler, MW (2012) 'Overwhelming Support Among Urban Irish COPD Patients for Lung Cancer Screening by Low-Dose CT Scan'. Lung, 190 :621-628. [DOI] [Details]
Hackett NR*, Butler MW*, Shaykhiev R*, Salit J, Omberg L, Rodriguez-Flores JL, Mezey JG, Strulovici-Barel Y, Wang G, Didon L, Crystal RG. *Joint first authors.; (2012) 'RNA-Seq Quantification of the Human Small Airway Epithelium Transcriptome'. BMC Genomics, 13 (1):82. [Details]
Cahalane AM, Kelly RM, O'Neill A, Moran D, Butler MW, Keane MP, Lawler L, Dodd JD; (2012) 'Bronchopleural cutaneous fistula after pulmonary radiofrequency ablation: treatment with low-adherent paraffin gauze dressing'. Journal of Vascular and Interventional Radiology, 23 (2):283-285. [DOI] [Details]
Butler MW, Fukui T, Salit J, Shaykhiev R, Mezey JG, Hackett NR, Crystal RG; (2011) 'Modulation of Cystatin A Expression in Human Airway Epithelium Related to Genotype, Smoking, COPD, and Lung Cancer'. Cancer Research, 71 (7):2572-2581. [DOI] [Details]
Butler MW, Hackett NR, Salit J, Strulovici-Barel Y, Omberg L, Mezey J, Crystal RG; (2011) 'Glutathione S-transferase copy number variation alters lung gene expression'. EUR RESPIR J, . [DOI] [Details]
Butler MW, Fabre A, Dodd JD; (2011) 'Smokers with interstitial lung abnormalities'. New England Journal of Medicine, 364 (25):2465-2465. [Details]
Guyot N, Bergsson G, Butler MW, Greene CM, Weldon S, Kessler E, Levine RL, O'Neill SJ, Taggart CC, McElvaney NG.; (2010) 'Functional study of elafin cleaved by Pseudomonas aeruginosa metalloproteinases'. Journal of Biological Chemistry, 391 (6):705-716. Available Online [Details]
Hunter-Zinck H, Musharoff S, Salit J, Al-Ali KA, Chouchane L, Gohar A, Matthews R, Butler MW, Fuller J, Hackett NR, Crystal RG, Clark AG.; (2010) 'Population genetic structure of the people of Qatar'. American Journal of Human Genetics, 87 (1):17-25. Available Online [Details]
Butler MW, Sanders A.; (2009) 'Obstructive shock in a 47 year old female with a deep venous thrombosis due to intravascular leiomyomatosis: a case report'. Cases journal, 2 :8159. Available Online [Details]
Meagher FM, Butler MW, Miller SD, Costello RW, Conroy RM, McElvaney NG.; (2009) 'Predictive validity of measurements of clinical competence using the team objective structured bedside assessment (TOSBA): assessing the clinical competence of final year medical students'. Medical Teacher, 31 (11). Available Online [Details]
Ammous Z, Hackett NR, Butler MW, Raman T, Dolgalev I, O'Connor TP, Harvey BG, Crystal RG.; (2008) 'Variability in small airway epithelial gene expression among normal smokers'. Chest, 133 (6):1344-1353. Available Online [Details]
Guyot N, Butler MW, McNally P, Weldon S, Greene CM, Levine RL, O'Neill SJ, Taggart CC, McElvaney NG; (2008) 'Elafin, an elastase-specific inhibitor, is cleaved by its cognate enzyme neutrophil elastase in sputum from individuals with cystic fibrosis'. Journal of Biological Chemistry, 283 (47):32377-32385. [DOI] [Details]
Miller SD*, Butler MW*, Meagher F, Costello RW, McElvaney NG. *Joint first authors; (2007) 'Team Objective Structured Bedside Assessment (TOSBA): a novel and feasible way of providing formative teaching and assessment'. Medical Teacher, 29 (2):156-159. Available Online [Details]
Butler MW, Robertson I, Greene CM, O'Neill SJ, Taggart CC, McElvaney NG.; (2006) 'Elafin prevents lipopolysaccharide-induced AP-1 and NF-kappaB activation via an effect on the ubiquitin-proteasome pathway'. J BIOL CHEM, 281 (46):34730-34735. Available Online [Details]
Butler MW, Saaidin N, Sheikh AA, Fennell JS.; (2006) 'Dissatisfaction with Do Not Attempt Resuscitation Orders: A nationwide study of Irish consultant physician practices'. Irish Medical Journal, 99 (7):208-210. [Details]
Butler MW, O'Mahony MJ, Donnelly SC, McDonnell TJ. ; (2004) 'Managing exacerbations of COPD: room for improvement'. Irish Medical Journal, 97 (4):108-110. [Details]
Butler MW, Mullan RH, Schaffer KE, Crotty TB, Luke DA, Donnelly SC.; (2003) 'Pulmonary cystic hydatid disease in Ireland'. IRISH J MED SCI, 172 (4):204-205. [Details]
Butler MW, Griffin JF, Quinlan WR, McDonnell TJ; (2001) 'Quinolone-associated tendonitis: a potential problem in COPD?'. IRISH J MED SCI, 170 (3):198-199. [Details]


Fearon, C,Fabre, A,Heffernan, EJ,Skehan, SJ,Swan, N,Keane, MP,Butler, MW (2013) Metastatic chordoma detected by endobronchial ultrasound-guided transbronchial needle aspiration. Editorial [DOI] [Details]


Cushen, B,Haroon, U,Williams, L,Leidin, CN,Butler, MW (2012) Non-Consultant Hospital Doctor (NCHD) Experience Regarding the Use of Bi-Level Non-Invasive Ventilation (NIV) in Patients with Chronic Obstructive Pulmonary Disease (COPD). Abstract [Details]
Fearon, C,Fabre, A,Heffernan, EJ,Skehan, SJ,Swan, N,Keane, MP,Butler, MW (2011) Metastatic Chordoma Detected by Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration. Abstract [Details]


Butler, MW,Fabre, A,Dodd, JD (2011) Smokers with Interstitial Lung Abnormalities. Letters [Details]


Research Interests

Relationships between germline and acquired genomic variation and gene expression in human lung disease.

Biomarkers of human pulmonary disease.

Phenotyping of smoke-induced lung disease states

Fibrogenic lung reactions in smoke-induced lung disease





Principal Investigator. 1/4/2013-31/3/2014. UCD Clinical research nurse for translational research in Chronic Obstructive Pulmonary Disease. Unrestricted funding 10,000 euros. Novartis Ireland.


Principal Investigator. 1/4/2013-1/4/2014Part time UCD COPD Clinical research nurse for translational research in Chronic Obstructive Pulmonary Disease. Unrestricted funding 10,000 euros. AstraZeneca Pharmaceuticals.




Principal Investigator. 1/3/2011-12/3/2013. UCD Clinical research nurse for translational research in Chronic Obstructive Pulmonary Disease. Unrestricted funding 50,000 euros. Nycomed Products Ireland.


Co-Principal Investigator: 7/1/2010-6/30/2011. Genetic Variability and Susceptibility to Type 2 Diabetes in the Qatari Population. $1,100,000 direct costs. Qatari National Research Fund (QNRF) National Priorities Research Fund (NPRP). Viewable at

Research Projects

Sponsor : University College Dublin Foundation Ltd.
Title : Part time UCD COPD Clinical Research Nurse
Start Date / End Date : 01-APR-13 / 01-APR-14
Sponsor : University College Dublin Foundation Ltd.
Title : UCD Part time Clinical Research Nurse in COPD
Start Date / End Date : 01-APR-13 / 31-MAR-14
Sponsor : Nycomed Products Ltd.
Title : Part time UCD Clinical Research nurse to facilitate COPD Research
Start Date / End Date : 21-MAR-11 / 21-MAR-13


Teaching Philosophy

2012: Module co-ordinator for Professional Completion Module MDSA 40160 in Medicine

Modules Coordinated

201600   MDSA40160     Medicine Systems One: Professional Completion

Enhancement of Teaching

In May 2012 I undertook a formal "Training the Trainers" course, (C/o Mr Dermot O'Flynn) which involved direct critique of my lecture presentation and skills teaching approaches, with constructive feedback used to enhance performance. In Sept 2012 I partook in an "Academic Activities" workshop, concerning bedside tutorial teaching and how to maximise effectiveness of such sessions.

Review and Enhancement of Curriculum

Developing as a Teacher

Training the Trainer course, RCSI Institute of Leadership, 2012 Academic Activities Workshop, RCPI Kildare Street, Sept 27th 2012

Innovation & Leadership

2016: Invited to serve as External Examiner for the School of Medicine, University of Dublin, Trinity College, for a three year term.