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Researchers at UCD

Maria Bengoechea Alonso

Research Fellow

School Of Medicine
Conway Institute
Belfield
Dublin 4

Tel: +353 1 7167653
Email: maria.bengoechea-alonso@ucd.ie

Publications

     

Peer Reviewed Journals

Bengoechea-Alonso MT, Ericsson J.; (2009) 'Quelling cholesterol pathway fends off brain damage'. Nature Medicine, . [Details]
Welcker M, Larimore EA;Swanger J;Bengoechea-Alonso MT;Grim JE;Ericsson J;Zheng N;Clurman BE (2013) 'Fbw7 dimerization determines the specificity and robustness of substrate degradation'. Genes and Development, 27 (23):2531-2536. [DOI] [Details]
Mu Y, Sundar R;Thakur N;Ekman M;Gudey SK;Yakymovych M;Hermansson A;Dimitriou H;Bengoechea-Alonso MT;Ericsson J;Heldin CH;Landstr¿¿m M (2011) 'TRAF6 ubiquitinates TGF¿¿ type I receptor to promote its cleavage and nuclear translocation in cancer'. Nature Communications, 2 . [DOI] [Details]
Bengoechea-Alonso MT, Ericsson J.; (2010) 'The ubiquitin ligase Fbxw7 controls adipocyte differentiation by targeting C/EBPalpha for degradation'. Proceedings of the National Academy of Sciences of the United States of America, . [Details]
Bengoechea-Alonso MT, Ericsson J.; (2010) 'Tumor suppressor Fbxw7 regulates TGFβ signaling by targeting TGIF1 for degradation'. Oncogene, . [Details]
Bengoechea-Alonso MT, Ericsson J; (2009) 'A phosphorylation cascade controls the degradation of active SREBP1'. Journal of Biological Chemistry, 284 (9):5885-5895. [DOI] [Details]
Bengoechea-Alonso MT, Ericsson J; (2007) 'SREBP in signal transduction: cholesterol metabolism and beyond'. Current Opinion in Cell Biology, 19 (2):215-222. [DOI] [Details]
Punga T, Bengoechea-Alonso MT, Ericsson J; (2006) 'Phosphorylation and ubiquitination of the transcription factor sterol regulatory element-binding protein-1 in response to DNA binding'. Journal of Biological Chemistry, 281 (35):25278-25286. [DOI] [Details]
Bengoechea-Alonso MT, Ericsson J; (2006) 'Cdk1/cyclin B-mediated phosphorylation stabilizes SREBP1 during mitosis'. Cell Cycle, 5 (15):1708-1718. [Details]
Sundqvist A, Bengoechea-Alonso MT, Ye X, Lukiyanchuk V, Jin J, Harper JW, Ericsson J; (2005) 'Control of lipid metabolism by phosphorylation-dependent degradation of the SREBP family of transcription factors by SCF(Fbw7)'. Cell Metabolism, 1 (6):379-391. [DOI] [Details]
Bengoechea-Alonso MT, Punga T, Ericsson J; (2005) 'Hyperphosphorylation regulates the activity of SREBP1 during mitosis'. Proceedings of the National Academy of Sciences of the United States of America, 102 (33):11681-11686. [DOI] [Details]
       

Editorial

Bengoechea-Alonso, MT,Ericsson, J; (2009) Quelling cholesterol pathway fends off brain damage. Editorial [DOI] [Details]
                                                                                   

Research

Research Interests

We work on the SREBP family of transcription factors. These proteins control cholesterol and lipid metabolism and play critical roles during adipocyte differentiation and insulin-dependent gene expression. Disturbances in lipid metabolism are at the very core of several major health issues facing modern society, including cardiovascular disease, obesity and diabetes. Thus, the factors and signals that regulate the function of the SREBP family of proteins are very relevant to metabolic disease.