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Mark Coyne

Assistant Professor In Clinical Pharmacology and Therapeutics

School of Medicine
C316
UCD School of Medicine & Medical Science
Health Science Centre
Belfield
Dublin 4

Tel: +353 1 716 6673
Email: mark.coyne@ucd.ie

Biography

Dr. Mark Coyne, Diop (Gaelige), PhD, MB BCh BAO, MRCPI, FRCPath is an Assistant Professor in Clinical Pharmacology and Therapeutics at the School of Medicine and Medical Science, and a Consultant Haematologist at the Mater Misericordiae University Hospital. Dr. Coyne's research interests include: amyloidoses; plasma cell disorders; pre-clinical model systems; bioinformatics; and related therapeutics. In 2014, Dr. Coyne received a Dr. Richard Steevens' scholarship to undertake work as a clinical fellow at the National Amyloidosis Centre, Royal Free Hospital, London. Dr. Coyne has completed research funded by the Irish Research Council's 'New Foundations' scheme, which has developed resources on amyloidosis for patients in Ireland, as well as materials and seminars for health professionals working in this field. Dr. Coyne's PhD research, completed at the National University of Ireland, Galway, the Mayo Clinic, Scottsdale, Arizona, and Johns Hopkins, Baltimore, Maryland, examined a  new class of dual CDC7/CDK9 inhibitors, mechanisms of proliferation, and proliferation-based stratification in myeloma. This research was funded by the Molecular Medicine Ireland Clinical-Scientist Fellowship programme. Dr. Coyne has also been funded by the Wellcome Trust, and the European Haematology Association - American Society of Hematology Translational Research Exchange Fellowship programme.

Professional

Honours and Awards

Year: 2015.
Title: New Foundations IRC Award
Year: 2004.
Title: Berman Scholarship - Hennepin County Medical Centre/Abbott Northwestern Medical Center, Minneapolis
Year: 2003.
Title: European Molecular Biology Laboratory Studentship - EMBL Heidelberg
Year: 2002.
Title: Wellcome Trust Studentship - Oxford University
Year: 2011.
Title: European Haematology Association/American Society of Haematology Translational Research Exchange Fellowship
Year: 2008.
Title: Molecular Medicine Ireland - Clinical Scientist Fellowship
Year: 2014.
Title: Dr Richard Steevens' Scholarship
       

Conference Contributions

Coyne MR, Naughton S, Hayden PJ, Montagnoli A, O'Dwyer ME, Santocanale C. (2009) Targeting Cdc7 Kinase in Multiple Myeloma. [Poster Presentation (Refereed)], The 51st American Society of Haematology Annual Meeting, San Francisco, CA, USA , 05-DEC-09 - 08-DEC-09.
Coyne MR, Wellik L, Braggio E, O'Dwyer ME, Santocanale C, Valdez R, Bergsagel PL, Chesi M. (2011) Examining Measures of Proliferation for Use in Risk Stratification of Myeloma. [Poster Presentation (Refereed)], The 53rd American Society of Haematology Annual Meeting, San Diego, CA, USA , 10-DEC-11 - 13-DEC-12.
Coyne MR, Bains J, Enright HM. (2012) Characteristics, Treatment Outcomes and survival of Irish patients with chronic myelomonocytic leukaemia. [Poster Presentation (Refereed)], Haematology Association of Ireland, Annual Conference 2012, Cork, Ireland , 19-OCT-12 - 21-OCT-12.
Coyne MR, Enright HM. (2013) Proteus Syndrome and Chronic Myeloid Leukaemia - a rare condition informing potential non BCR-ABL resistance. [Oral Presentation], European Leukaemia Network; European Treatment and Outcome Study - CML - Fellows' Study Day, Naples, Italy , 13-MAY-13 - 14-MAY-13.
Ramsay I, De-silva D, Worthington S, Coyne M, Wechalekar A, Griffiths PD (2015) Is Treatment with Bortezomib for Multiple Myeloma or Amyloidosis Associated with Cytomegalovirus Reactivation?. [Poster Presentation (Refereed)], The 57th American Society of Haematology Annual Meeting, Orlando, FL, USA , 05-DEC-15 - 06-DEC-15.
Mahmood S, Coyne MR, Wechalekar AD. (2015) Bleeding diathesis and prothrombotic tendencies in newly diagnosed systemic light chain Amyloidosis patients: important clinical implications in management. [Poster Presentation (Refereed)], The 15th International Myeloma Workshop, Rome, Italy , 23-SEP-15 - 26-SEP-15.
Coyne MR, Baginska A, Rowczenio D, Wechalekar A. (2016) Evaluating the use of Multiparametric Flow Cytometry in establishing the presence of Minimal Residual Disease in systemic AL amyloidosis: a report of eight patients. [Poster Presentation (Refereed)], The XVth International Symposium on Amyloidosis, Uppsala, Sweden , 03-JUL-16 - 07-JUL-16.
   

Education

Year 2011 Institution: Educational Committee for Foreign Medical Graduates, USMLE
Qualification: Licence// Subject:
Year 2007 Institution: Royal College of Physicians, Ir
Qualification: MRCPI Subject:
Year 2005 Institution: NUI Galway, IRL
Qualification: MB, BCh, BAO Subject:
Year 2015 Institution: NUI Galway, IRL
Qualification: PhD Subject:
Year 2003 Institution: NUI Galway, IRL
Qualification: Dioplóma sa Ghaeilge Subject:
         

Publications

     

Peer Reviewed Journals

AE Timms, AM Crane, AM Sims, L Bradbury, O Beynon, MRE Coyne, I Herzberg, A Abbott, LR Cardon, GR Duff, A Calin, P Wordsworth, MA Brown (2003) 'The IL1 gene cluster is a major locus determining susceptibility to Ankylosing spondylitis'. Arthritis and Rheumatism, 48 (9):S256-S256. [Details]
S Mahmood, A Riddle, S Sachchithanantham, T Lane, D Foard, T Youngstein, R Sayed, K Patel, M Fontanna, M Coyne, C Quarta, CJ Whelan, HJ Lachmann, JD Gillmore, PN Hawkins, K Gomez, AD Wechalekar (2015) 'Bleeding diathesis and prothrombotic tendencies in patients with newly diagnosed systemic light chain Amyloidosis: important clinical implications'. Clinical Lymphoma, Myeloma and Leukemia, 15 :e201. [Details]
M Coyne, A Baginska, D Rowczenio, AD Wechalekar (2015) 'Evaluating the use of Multiparametric Flow Cytometry in establishing the presence of Minimal Residual Disease in systemic AL amyloidosis: a report of eight patients'. Clinical Lymphoma, Myeloma and Leukemia, 15 :e185. [Details]
A Wechalekar, AD Wechalekar, SA Mahmood, T Youngstein, M Coyne, D Foard, T Lane, C Whelan, M Fontana, HJ Lachmann, PN Hawkins, JD Gillmore (2015) 'Interim analysis of ALCHemy-a prospective study of 1000 patients with Systemic AL amyloidosis'. Clinical Lymphoma, Myeloma and Leukemia, 15 :e60. [Details]
S Mahmood, A Riddle, S Sachchithanantham, T Lane, D Foard, R Sayed, K Patel, M Fontana, T Youngstein, C Youngstein, M Coyne, C Whelan, H Lachmann, J Gillmore, P Hawkins, K Gomez, A Wechaleka (2015) 'ELEVATED FACTOR VIII LEVELS CARRY A POOR OVERALL SURVIVAL IN NEWLY DIAGNOSED SYSTEMIC LIGHT CHAIN (AL) AMYLOIDOSIS PATIENTS'. Haematologica, 100 :513-514. [Details]
Peter O'Gorman, Michael E O'Dwyer, Oonagh Gilligan, John Quinn, Mark Coyne, Janusz Krawczyk, Philip T Murphy, Lourdes del Rosario McAlester, Orna Harraghy, Orlaith Cormican, Elizabeth Lenihan, Keith Egan, Meegahage Ratnakanthi Perera, Gerard Crotty, Patrick J Hayden, Brian Hennessy, Hilary M O'Leary, Kathleen Scott, Imelda Parker, Michele Cunnane, Jacinta Marron, Aoife Connell, Elizabeth Coghlan, Jacob P Laubach, Paul G Richardson (2016) 'A Phase II Multi-Center Study of Lenalidomide, Subcutaneous Bortezomib and Dexamethasone (RsqVD) in Newly Diagnosed Multiple Myeloma-Ctrial-IE (ICORG) 13-17 Study'. Blood, 128 (22):2117-2117. [Details]
Timms AE, Crane AM, Sims AM, Cordell HJ, Bradbury LA, Abbott A, Coyne MR, Beynon O, Herzberg I, Duff GW, Calin A, Cardon LR, Wordsworth BP, Brown MA. (2004) 'The interleukin 1 gene cluster contains a major susceptibility locus for ankylosing spondylitis'. American Journal of Human Genetics, 75 (4):587-595. [DOI] [Details]
Coyne MRE, Naughton S, Hayden PJ, Montagnoli A, O'Dwyer ME,Santocanale C. (2009) 'Targeting Cdc7 Kinase in Multiple Myeloma'. Blood, 114 (22):3847-3847. [Details]
Coyne MRE, Wellik L, Braggio E, O'Dwyer ME, Santocanale C, Valdez R, Bergsagel PL, Chesi M. (2011) 'Examining Measures of Proliferation for Use in Risk Stratification of Myeloma'. Blood, 118 (21):5093-5093. [Details]
Natoni A, Coyne MR, Jacobsen A, Rainey MD, O'Brien G, Healy S, Montagnoli A, Moll J, O'Dwyer M, Santocanale C. (2013) 'Characterization of a Dual CDC7/CDK9 Inhibitor in Multiple Myeloma Cellular Models'. Cancers, 5 (3):901-918. [DOI] [Details]
Ramsay I, De-silva D, Worthington S, Coyne MR, Wechalekar AD, Griffiths PD. (2015) 'Is Treatment with Bortezomib for Multiple Myeloma or Amyloidosis Associated with Cytomegalovirus Reactivation?'. Blood, 126 (23):4259-4259. [Details]
                                                                                                                     

Research

Research Interests

Amyloidoses; plasma cell disorders; pre-clinical model systems; bioinformatics; and related therapeutics.

Research Projects

Sponsor : Irish Research Council (IRC)
Title : Amyloidosis: Global Innovations, Irish Responses (AGIIR)
Start Date / End Date : 01-MAR-16 / 20-NOV-16