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Researchers at UCD

Mark Pickering

Lecturer

School Of Medicine
Health Sciences Centre
Belfield
Dublin 4

Tel: +353 1 7166621
Email: mark.pickering@ucd.ie

Publications

 

Book Chapters

Pickering, M. & O'Connor J.J; (2007) 'Cytokines and their effects in the dentate gyrus' In: Scharfman, H (eds). The Dentate Gyrus: A Comprehensive Guide to Structure, Function, and Clinical Implications. USA: Springer. , pp.339-354 [Details]
 

Peer Reviewed Journals

Power, B.J. and O'reilly, G. and Murphy, R. and Murphy, K.J. and Pickering, M. and Jones, J.F.X. (2015) 'Normal nerve striations are altered in the trembler-J mouse, a model of charcot-marie-tooth disease'. Muscle and Nerve, 51 (2):246-252. Available Online [DOI] [Details]
Watters, O., Pickering, M., Murphy, R., Murphy, K., O'Connor J.J (2014) 'Automated analysis of intracellular calcium fluorescence in rat organotypic hippocampal cultures: comparison to a manual, observer based method'. Journal of Neuroscience Methods, 223 :20-29. Link to full text [Details]
Sheridan, G.K., Pickering, M., Watters, O., Halley, P.G., O¿Sullivan, N.C., Mooney, C., O¿Connor, J.J., Murphy, K.J. (2014) 'CX3CL1 is up-regulated in the rat hippocampus during memory-associated synaptic plasticity'. Frontiers in Cellular Neuroscience, 8 :233-243. [DOI] Link to full text [Details]
Sheridan, G.K., Moeendarbary E., Pickering M., O'Connor J.J., Murphy K.J. (2014) 'Theta-burst stimulation of hippocampal slices induces network-level calcium oscillations and activates analogous gene transcription to spatial learning'. PLoS ONE, 9 (6):e100546-e100546. [DOI] Link to full text [Details]
Lukasz B, O'Sullivan NC, Loscher JS, Pickering M, Regan CM, Murphy KJ (2013) 'Peripubertal viral-like challenge and social isolation mediate overlapping but distinct effects on behaviour and brain interferon regulatory factor 7 expression in the adult Wistar rat'. Brain, behavior, and immunity, 27 (1):71-79. [DOI] [Details]
Murphy RP, Murphy KJ, Pickering M (2013) 'The development of myelin repair agents for treatment of multiple sclerosis: Progress and challenges'. Bioengineered, 4 (3):140-146. [Details]
Sheridan, G.K., Pickering, M., Watters, O., Halley, P.G., O¿Sullivan, N.C., Mooney, C., O¿Connor, J.J., Murphy, K.J. (2012) 'CX3CL1 is up-regulated in the rat hippocampus during memory-associated synaptic plasticity'. PLoS ONE, . [Details]
Griffin KM, Pickering M, O'Herlihy C, O'Connell PR, Jones JF; (2011) 'Sacral nerve stimulation increases activation of the primary somatosensory cortex by anal canal stimulation in an experimental model'. British Journal of Surgery, 98 (8):1160-1169. [DOI] [Details]
Watters O, Pickering M, O'Connor J.J.; (2011) 'Preconditioning effects of tumor necrosis factor-α and glutamate on calcium dynamics in rat organotypic hippocampal cultures'. Journal of Neuroimmunology, 234 (1-2):27-39. [DOI] Link to full text [Details]
O'Sullivan, Niamh C. and Croydon, Lawrence and McGettigan, Paul A. and Pickering, Mark and Murphy, Keith J.; (2010) 'Hippocampal region-specific regulation of NF-kappa B may contribute to learning-associated synaptic reorganisation'. BRAIN RESEARCH BULLETIN, 81 (4-5):385-390. [DOI] [Details]
O'Sullivan NC, Pickering M, Di Giacomo D, Loscher JS, Murphy KJ. (2010) 'Mkl transcription cofactors regulate structural plasticity in hippocampal neurons'. Cerebral cortex (New York, N.Y. : 1991), . Available Online [Details]
Meng, Jianghui and Ovsepian, Saak V. and Wang, Jiafu and Pickering, Mark and Sasse, Astrid and Aoki, K. Roger and Lawrence, Gary W. and Dolly, J. Oliver; (2009) 'Activation of TRPV1 Mediates Calcitonin Gene-Related Peptide Release, Which Excites Trigeminal Sensory Neurons and Is Attenuated by a Retargeted Botulinum Toxin with Anti-Nociceptive Potential'. JOURNAL OF NEUROSCIENCE, 29 (15):4981-4992. [DOI] [Details]
Watters, O. and O'Connor, J. J. and Sheridan, G. K. and Murphy, K. J. and Pickering, M.; (2008) 'Modulation of glutamate excitotoxicity and ischemic preconditioning by TNF-alpha depends on time and order of TNFa and glutamate exposure'. JOURNAL OF NEUROIMMUNOLOGY, 197 (2):171. [Details]
ter Horst, JPF,Loscher, JS,Pickering, M,Regan, CM,Murphy, KJ; (2008) 'Learning-associated regulation of polysialylated neural cell adhesion molecule expression in the rat prefrontal cortex is region-, cell type- and paradigm-specific'. European Journal of Neuroscience, 28 :419-427. [DOI] [Details]
Pickering M, Pickering BW,Murphy KJ, O'Connor JJ; (2008) 'Discrimination of cell types in mixed cortical culture using calcium imaging: a comparison to immunohistochemical labeling'. Journal of Neuroscience Methods, . [Details]
O'Sullivan N.C., McGettigan P.A., Sheridan, G.K., Pickering, M., Conboy, L., O'Connor, J.J., Moynagh, P.N., Higgins, D.G., Regan, C.M., Murphy, K.J. ; (2007) 'Temporal change in gene expression in the rat dentate gyrus following passive avoidance learning'. Journal of Neurochemistry, 101 (4):1085-1098. [Details]
Cumiskey, D,Pickering, M,O'Connor, JJ; (2007) 'Interleukin-18 mediated inhibition of LTP in the rat dentate gyrus is attenuated in the presence of mGluR antagonists'. Neuroscience Letters, 412 :206-210. [DOI] [Details]
Sheridan, GK,Pickering, M,Twomey, C,Moynagh, PN,O'Connor, JJ,Murphy, KJ; (2007) 'NF-kappa B activity in distinct neural subtypes of the rat hippocampus: Influence of time and GABA antagonism in acute slice preparations'. Learning and Memory, 14 :525-532. [DOI] [Details]
Pickering, M. & O¿Connor J.J. ; (2007) 'Cytokines and their effects in the dentate gyrus'. Progress in Brain Research, 163 :339-354. [Details]
Pickering M, Jones JF.; (2007) 'Comparison of the motor discharge to the crural and costal diaphragm in the rat'. Respiratory Physiology & Neurobiology, 159 (1):21-27. [Details]
Cumiskey D., Pickering M., O'Connor J.J. ; (2006) 'Interleukin-18 mediated inhibition of LTP in the rat dentate gyrus is attenuated in the presence of mGluR antagonists'. Neuroscience Letters, 412 (3):206-210. [Details]
Brunnschweiler, JM and Andrews, PLR and Southall, EJ and Pickering, M and Sims, DW; (2005) 'Rapid voluntary stomach eversion in a free-living shark'. JOURNAL OF THE MARINE BIOLOGICAL ASSOCIATION OF THE UNITED KINGDOM, 85 (5):1141-1144. [Details]
Pickering, M; Cumiskey, D; O'Connor, JJ; ; (2005) 'Actions of TNF-alpha on glutamatergic synaptic transmission in the central nervous system'. Experimental Physiology, 90 (5):663-670. [Details]
Pickering, M and Campion, D and Jones, JFX; (2004) 'A gastrointestinal role for the amphibian `diaphragm' of Xenopus laevis'. JOURNAL OF ZOOLOGY, 264 (Part 1):45-51. [Details]
O'Leary, DM,Murphy, A,Pickering, M,Jones, JFX; (2004) 'Arterial chemoreceptors in the superior laryngeal nerve of the rat'. Respiratory Physiology Neurobiology, 141 :137-144. [DOI] [Details]
Hughes, K, Pickering, M, O'Leary, DM, Bradford, A, O'Regan, RG, Jones, JFX, ; (2003) 'The paraganglia of the rat superior laryngeal nerve'. Advances in Experimental Medicine and Biology, 536 (NA):239-246. [Details]
Jones, JFX,O'Leary, DM,Pickering, M; (2003) 'Vagal control of the cranial venae cavae of the rat heart'. Experimental Physiology, 88 :329-334. [Details]
Pickering, M and Campion, D and Jones, JFX; (2002) 'Reflex cardiorespiratory effects of nociceptive oesophageal distension in the decerebrate rat'. EXPERIMENTAL PHYSIOLOGY, 87 (1):41-48. [Details]
Pickering, M; Jones, JFX; ; (2002) 'The diaphragm: two physiological muscles in one'. Journal of Anatomy, 201 (4):305-312. [Details]
Pickering, M,Campion, D,Jones, JFX; (2002) 'Reflex cardiorespiratory effects of nociceptive oesophageal distension in the decerebrate rat'. EXPERIMENTAL PHYSIOLOGY, 87 (NA):41-48. [Details]
 

Conference Publications

O'Shea SD, Keogh EA, Murphy RP, Bowen G, Pickering M, Murphy KJ (2013) Exploring the mechanism of action of the novel remyelinating therapeutic nefiracetam XI European Meeting on Glial Cells in Health and Disease , pp.S135 [Details]
Murphy RP, Keogh EA, O'Shea SD, Bowen G, Pickering M, Murphy KJ (2013) The nootropic agent nefiracetam is a potential remyelinating therapeutic in vivo XI European Meeting on Glial Cells in Health and Disease , pp.S134 [Details]
Sheridan GK, Pickering M, Watters O, Halley PG, O'Sullivan NC, Mooney C, O'Connor JJ, Murphy KJ (2012) CX3CL1 is up-regulated in the rat hippocampus during memory-associated synaptic plasticity Society for Neuroscience Annual Meeting 2012 [Details]
Sheridan, G.K., Pickering, M., Halley, P., O'Sullivan, N.C., O'Connor, J.J., Murphy, K.J. ; (2010) The chemokine, fractalkine (CX3CL1), modulates synaptic plasticity and is upregulated in the rat hippocampus following a spatial learning task Neuroscience Ireland Meeting [Details]
Sheridan, G.K., Pickering, M., O'Connor, J.J., Moynagh, P.N., Murphy, K.J. ; (2010) Similar temporal oscillations in hippocampal NF-kB following spatial learning in rats and high-frequency stimulation of organotypic slice cultures Neuroscience Ireland Meeting [Details]
Sheridan, G.K., Pickering, M., O'Connor, J.J., Moynagh, P.N., Murphy, K.J. ; (2010) Similar temporal oscillations in hippocampal NF-kB following spatial learning in rats and high-frequency stimulation of organotypic slice cultures Neuroscience Ireland Meeting, TCD. Irish Journal of Medical Science [Details]
Sheridan GK, Pickering M, O¿Connor JJ, PN Moynagh and Murphy KJ (2009) Similar temporal oscillations in hippocampal NF-κB following spatial learning in rats and high frequency stimulation of organotypic slice cultures Neuroscience Ireland [Details]
Sheridan GK, Pickering M, Halley P, O¿Sullivan NC, O¿Connor JJ and Murphy KJ (2009) The chemokine, fractalkine (CX3CL1), modulates synaptic plasticity and is upregulated in the rat hippocampus following a spatial learning task Neuroscience Ireland [Details]
O¿Sullivan NC, Pickering M, Carr F, DiGiacomo D, Loscher JS and Murphy KJ (2009) The transcription cofactor Mkl regulates hippocampal memory-associated neuronal structural reorganisation Neuroscience Ireland [Details]
O¿Neill T, Pickering M and Murphy KJ (2009) The effect of general anaesthetic agents on hippocampal neuronal structure and psa-ncam expression Neuroscience Ireland [Details]
Nic Raghnaill M, Doyle K, Scollard S, Ring RH, Pangalo MN, Regan CM, Pickering M and Murphy KJ (2009) The bone morphogenetic protein inhibitors chordin, gremlin and noggin differentially regulate dendritic structure, neuronal activity and spatial learning Neuroscience Ireland [Details]
Murphy RP, Murphy KJ and Pickering M (2009) Gut peptide hormones ghrelin and obestatin differentially effect structure and synaptic function of rat hippocampal neurones in vitro Neuroscience Ireland [Details]
Watters O., O¿Connor J.J., Sheridan G.K., Murphy K.J. & Pickering M. ; (2008) Modulation of glutamate excitotoxicity and ischemic pre-conditioning by TNFα depends on time and order of TNFα and glutamate exposure J. Neuroimmunology, Vol. 197, page 171 [Details]
Watters, O., O'Connor, J. J., Sheridan, G. K., Murphy, K. J., Pickering, M., ; (2008) Modulation of glutamate excitotoxicity and ischemic preconditioning by TNF-alpha depends on time and order of TNFa and glutamate exposure Journal of Neuroimmunology , pp.171-171 [Details]
Sheridan, G. K., Pickering, M., Moynagh, P. N., O'Connor, J. J., Murphy, K. J. ; (2007) Temporal changes in nuclear factor-kappa B activity in distinct neuronal subpopulations of the rat hippocampus following spatial learning Society for Neuroscience , pp.207.5 [Details]
O¿Connor JJ, Watters O, Sheridan GK, Murphy KJ & Pickering M. ; (2007) Modulation of glutamate excitotoxicity and ischemic preconditioning by TNFα depends on time and order of TNFα and glutamate exposure Society for Neuroscience [Details]
O'Connor JJ, Watters O, Sheridan GK, Murphy KJ & Pickering M; (2007) TNFalpha-mediated modulation of glutamate excitotoxicity and ischemic preconditioning is time and sequence of TNFalpha and glutamate exposure-dependent Society for Neuroscience Annual Meeting 2007 [Details]
Loscher JS, Pickering B, Pickering M, Murphy KJ ; (2007) The nootropic nefiracetam prevents isoflurane-induced post-operative cognitive dysfunction (pocd) in aged wistar rats Society for Neuroscience Annual Meeting 2007 [Details]
O'Sullivan NC, McGettigan PA, Croydon L, Sheridan GK, Pickering M, Ring RH, von Schack D, Higgins DG, Regan CM, Murphy KJ ; (2007) Cell type- and region-specific regulation of nuclear factor kappa-B p65 activity in the hippocampus during consolidation of an avoidance conditioning task Society for Neuroscience Annual Meeting 2007 [Details]
Sheridan G, Pickering M, Moynagh PN, O'Connor JJ, Murphy KJ ; (2007) Temporal changes in nuclear factor kappa-B activity in distinct neuronal subpopulations of the rat hippocampus following spatial learning Society for Neuroscience Annual Meeting 2007 [Details]
Sheridan G., Pickering M., Moynagh P.N., O'Connor J.J. and Murphy K.J.; (2006) Tumour necrosis factor-α selectively upregulates nuclear factor κb expression in hippocampal sub-neuronal populations British Journal of Pharmacology, Vol 3, Issue 4, 113P [Details]
Pickering, M., Pickering, B.W., Murphy, K.J., O'Connor, J.J. ; (2006) Discrimination of neurones and glia using calcium imaging in primary mixed cell culture models of glutamate excitotoxicity Irish journal of Medical Science, Volume 175(3) (electronic supplement 1) , pp.100 [Details]
Pickering, B.W., Pickering, M., O'Connor, J.J., Murphy, K.J. ; (2006) The anaesthetic agents propofol and isoflurane differentially effect glutamate-induced calcium influx in primary cultured neurones and glia Irish journal of Medical Science, Volume 175(3) (electronic supplement 1) , pp.40 [Details]
Sheridan, G.K., Pickering, M., Twomey, C., Moynagh, P.N., O'Connor, J.J., Murphy, K.J.; (2006) GABA receptor blockade increases NFκb activation in neuroplastic cells of the rat dentate gyrus while decreasing its activity in more mature granule neurons Irish journal of Medical Science, Volume 175(3) (electronic supplement 1) , pp.78 [Details]
Sheridan, G., Pickering, M., Moynagh, P.N., O'Connor, J.J. and Murphy, K.J.; (2006) Tumour necrosis factor-α selectively upregulates nuclear factor κb expression in hippocampal sub-neuronal populations Royal Academy of Medicine in Ireland, Section of Biomedical Sciences UCD, , 12-JAN-06 [Details]
Sheridan, G.K., Pickering, M., Twomey, C., Moynagh, P.N., O'Connor, J.J., Murphy, K.J. ; (2006) GABA receptor blockade increases NFκb activation in neuroplastic cells of the rat dentate gyrus while decreasing its activity in more mature granule neurons RAMI [Details]
Pickering, B.W., Pickering, M., O'Connor, J.J., Murphy, K.J. ; (2006) The anaesthetic agents propofol and isoflurane differentially effect glutamate-induced calcium influx in primary cultured neurones and glia RAMI [Details]
Hughes, K,Pickering, M,O'Leary, DM,Bradford, A,O'Regan, RG,Jones, JFX (2003) CHEMORECEPTION: FROM CELLULAR SIGNALLING TO FUNCTIONAL PLASTICITY The paraganglia of the rat superior laryngeal nerve , pp.239-246 [Details]
Pickering, M,Jones, JFX (2002) JOURNAL OF ANATOMY The diaphragm: two physiological muscles in one , pp.305-312 [Details]
                       

Abstract

Power, BJ,Jones, JFX,Pickering, M (2012) A STUDY OF THE BIOMECHANICS AND ELECTROPHYSIOLOGY OF PERIPHERAL NERVES IN RESPONSE TO STRETCH. Abstract [Details]
Murphy, R,Wyse, L,Murphy, KJ,Pickering, M (2011) DEVELOPMENT AND CHARACTERIZATION OF AN IN VITRO DEMYELINATION SYSTEM FOR SCREENING POTENTIAL REMYELINATING THERAPEUTICS. Abstract [Details]
Gleize, JJ,Bowen, G,Murphy, MA,Pickering, M,Murphy, KJ,O'Connell, DJ (2011) SECRETAGOGIN: MAPPING THE EXPRESSION OF A NOVEL CALCIUM-BINDING PROTEIN IN THE RODENT BRAIN. Abstract [Details]
Raghnaill, MN,Doyle, K,Scollard, S,Ring, RH,Pangalos, MN,Regan, CM,Pickering, M,Murphy, KJ (2010) THE BONE MORPHOGENETIC PROTEIN INHIBITORS CHORDIN, GREMLIN AND NOGGIN DIFFERENTIALLY REGULATE DENDRITIC STRUCTURE, NEURONAL ACTIVITY AND SPATIAL LEARNING. Abstract [Details]
Cassidy, AW,Carolan, D,Pickering, M,Regan, CM (2010) CYTOKINE MEDIATED REGULATION OF REELIN EXPRESSION AND SECRETION IN CULTURED SH-SY5Y NEURONS. Abstract [Details]
O'Neill, T,Pickering, M,Murphy, K (2010) THE EFFECT OF GENERAL ANAESTHETIC AGENTS ON HIPPOCAMPAL NEURONAL STRUCTURE AND PSA-NCAM EXPRESSION. Abstract [Details]
O'Sullivan, NC,Pickering, M,Carr, F,Di Giacomo, D,Loscher, JS,Murphy, KJ (2010) THE TRANSCRIPTION COFACTOR MKL REGULATES HIPPOCAMPAL MEMORY-ASSOCIATED NEURONAL STRUCTURAL REORGANISATION. Abstract [Details]
Murphy, RP,Murphy, KJ,Pickering, M (2010) GUT PEPTIDE HORMONES GHRELIN AND OBESTATIN DIFFERENTIALLY EFFECT STRUCTURE AND SYNAPTIC FUNCTION OF RAT HIPPOCAMPAL NEURONES IN VITRO. Abstract [Details]
Sheridan, GK,Pickering, M,O'Connor, JJ,Moynagh, PN,Murphy, KJ (2010) SIMILAR TEMPORAL OSCILLATIONS IN HIPPOCAMPAL NF-kappa B FOLLOWING SPATIAL LEARNING IN RATS AND HIGH-FREQUENCY STIMULATION OF ORGANOTYPIC SLICE CULTURES. Abstract [Details]
Sheridan, GK,Pickering, M,Halley, P,O'Sullivan, NC,O'Connor, JJ,Murphy, KJ (2010) THE CHEMOKINE, FRACTALKINE (CX3CL1), MODULATES SYNAPTIC PLASTICITY AND IS UPREGULATED IN THE RAT HIPPOCAMPUS FOLLOWING A SPATIAL LEARNING TASK. Abstract [Details]
Watters, O,O'Connor, JJ,Sheridan, GK,Murphy, KJ,Pickering, M (2008) Modulation of glutamate excitotoxicity and ischemic preconditioning by TNF-alpha depends on time and order of TNFa and glutamate exposure. Abstract [Details]
       

Reviews

Pickering, M,O'Connor, JJ (2007) Pro-inflammatory cytokines and their effects in the dentate gyrus. Reviews [DOI] [Details]
Pickering, M,Cumiskey, D,O'Connor, JJ (2005) Actions of TNF-alpha on glutamatergic synaptic transmission in the central nervous system. Reviews [DOI] [Details]
                                                     

Research

Research Interests

My research is currently focused on the biology of myelin in the central and peripheral nervous system, Myelin repair as a therapeutic strategy for demyelinating diseases, Neuro-glial interactions

My research is primarily concerned with the biology of myelin in the central and peripheral nervous systems in health and disease. Several neurological conditions, such as multiple sclerosis and Charcot-Marie-Tooth disease, result from damage to myelin, and a failure of the endogenous myelin repair mechanisms. Therefore, a particular focus of our work is investigating the process of myelin formation, both in development and repair, and the development of novel therapeutic agents to enhance this process.

Research Projects

Sponsor : University College Dublin (UCD)
Title : Developing a novel treatment for Multiple Sclerosis.
Start Date / End Date : 17-MAY-10 / 16-NOV-11
Sponsor : University College Dublin (UCD)
Title : Startup grant
Start Date / End Date : 01-OCT-12 / 30-MAR-16
Sponsor : University College Dublin (UCD)
Title : Developing the ctenophore nervous system as a model for studying neural coding.
Start Date / End Date : 01-APR-15 / 30-SEP-16
Sponsor : Irish Research Council (IRC)
Title : Development of novel regenerative therapy for demyelinating Charcot Marie Tooth disease
Start Date / End Date : 01-OCT-13 / 30-SEP-16
 

Current Postgraduate Students

Luke Alvey, Doctor of Philosophy (PhD)   -   Thesis Supervisor