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Matthew Lawless

Adjunct Lecturer/Assistant Professor

School Of Medicine
Mater Hospital
Eccles Street
Dublin 7

Tel: +353 1 7164597
Email: matthew.lawless@ucd.ie

Biography

Dr. Matthew Lawless graduated from NUI Maynooth with an honours B.Sc. degree in 2000 and obtained a PhD in Medicine from the Department of Medicine, Royal College of Surgeons in Ireland in 2004, with Professor Gerry McElvaney. This research was awarded the Sheppard's research medal prize, from the Royal College of Surgeons, Beaumont hospital and a Health Research Board project grant for liver research. During this time he was directly involved with a leading large-scale clinical trial with the University of Florida.

In 2004, Dr. Lawless was appointed senior postdoctoral fellow and lecturer in liver immunology at Trinity College Dublin and St. James Hospital, with Professor Suzanne Norris. He developed his own Experimental Medicine research group focused on the understanding of endoplasmic reticulum stress and epigenetic factors in the liver. Dr. Lawless has international expertise in liver cancer assoicated liver diseases including hepatitis C, hereditary haemochromatosis and the childhood liver cancer Z Alpha-1 antitrypsin deficiency. In 2008, Dr. Lawless was awarded an M.Sc. in Healthcare Management from the Department of International Healthcare Management, Royal College of Surgeons in Ireland.
In 2008, Dr. Lawless was appointed to the Mater Misericordiae University Hospital, Department of Health and Children. Dr. Lawless expanded his research themes in chronic liver disease and immunomodulation associated with the development of Liver Cancer. 

In 2010, Dr Lawless was elected to fellowship with the Society of Biology
in London. In 2012, he was awarded Lecturership with UCD
School of Medicine and Medical Science. Dr. Lawless's academic involvements include the supervision and co-supervised of several undergraduate and postgraduate students to competition of B.Sc., M.Sc., M.D. and PhD degree. His research has been extensively published in numerous high impact journals including Hepatology, the Journal of Immunology, with authored book chapters on these themes. Dr. Lawless serves as an expert reviewer and Editoral Board Member for leading international journals including Gut, British Journal of Haematology, Cytokine, FASEB, World Journal of Hepatology, Annals of Hepatology, Journal of Hepatology and the International Journal of Biochemistry and Cell Biology. He has presented his research findings and won awards both nationally and internationally at several diverse internationally well-recognised conferences.                                                                  

Professional

           

Committees

Committee : Trinity Research Staff Association (TRSA)
Committee : Molecular Diagnostics Committee, International Federation of Clinical Chemistry and Laboratory Medicine (IFCC)
             

Publications

 

Book Chapters

O'Grady, S; Lawless, MW (2015) 'Liver cancer (Hepatocellular carcinoma)' In: Gray, SG (eds). Epigenetic Cancer Therapy; Translational Epigenetics. Amsterdam: Elsevier. [Details]
Zhao, J; Lawless, MW (2015) 'ncRNA as diagnostics and prognostics for hepatocellular carcinoma' In: Greene, C (eds). MicroRNAs and Other Non-coding RNAs in Inflammation. New York, Philadelphia: Springer. [Details]
Matthew W Lawless (2009) 'Protein Misfolding: A New Paradigm HFE C282Y Hereditrary Hemochromatosis' In: Matthew W Lawless (eds). Protein Misfolding. Hauppauge, New York: Nova Science Publishers, Inc., Nova Science Publishers, Inc.. [Details]
Matthew W Lawless (2009) 'The Serine Proteinase Inhibitors Z Alpha-1 Antitrypsin: Acting on the NF-kappaB system for cytotoxicity' In: Matthew W Lawless (eds). Serpins and Protein Kinase Inhibitors: Novel Functions, Structural Features and Molecular Mechanisms. Hauppauge, New York: Nova Science Publishers. [Details]
 

Peer Reviewed Journals

Zhao J, Greene CM;Gray SG;Lawless MW (2014) 'Long noncoding RNAs in liver cancer: what we know in 2014'. Expert Opinion on Therapeutic Targets, 18 (10):1207-1218. [DOI] [Details]
Greene CM, Varley RB, Lawless MW (2013) 'MicroRNAs and liver cancer associated with iron overload: Therapeutic targets unravelled'. World journal of gastroenterology : WJG, 28;19(32) :5212-5226. [Details]
Zhao J, Lawless MW (2013) 'Stop feeding cancer: pro-inflammatory role of visceral adiposity in liver cancer'. Cytokine, 64 (3):626-637. [DOI] [Details]
Zhao J, Lawless MW (2013) 'Long noncoding RNAs and their role in the liver cancer axis'. Nature Reviews Gastroenterology and Hepatology, . [DOI] [Details]
C. Ryan JD, Altamura, EJ, Devitt E, Mulllins S, Lawless MW, Muckenthaler MU, Crowe J. (2012) 'Hepcidin induced hypoferraemia is associated with viral suppression upon combination treatment for Hepatitis'. Hepatology, . [Details]
Lawless MW, Greene CM (2012) 'Toll-like receptor signalling in liver disease: ER stress the missing link?'. Cytokine, 59 (2):195-202. [DOI] [Details]
Ryan, JD,Altamura, S,Devitt, E,Mullins, S,Lawless, MW,Muckenthaler, MU,Crowe, J (2012) 'Pegylated interferon-alpha induced hypoferremia is associated with the immediate response to treatment in hepatitis C'. Journal of Hepatology, 56 :492-500. [DOI] [Details]
White M, Martin-Loeches I, Lawless MW, O'Dwyer MJ, Doherty DG, Young V, Kelleher D, McManus R, Ryan T (2011) 'Hospital-acquired pneumonia after lung resection surgery is associated with characteristic cytokine gene expression'. Chest, 139 (3):626-632. [DOI] [Details]
Devitt EJ, Power KA, Lawless MW, Browne JA, Gaora PO, Gallagher WM, Crowe J (2011) 'Early proteomic analysis may allow noninvasive identification of hepatitis C response to treatment with pegylated interferon α-2b and ribavirin'. Journal of Gastroenterology, 23 (2):177-183. [DOI] [Details]
Ryan JD, Ryan E, Fabre A, Lawless MW, Crowe J (2010) 'Defective bone morphogenic protein signaling underlies hepcidin deficiency in HFE hereditary hemochromatosis'. Journal of Hepatology, 52 (4):1266-1273. [DOI] [Details]
Lawless, MW,O'Byrne, KJ,Gray, SG (2010) 'Targeting oxidative stress in cancer'. Expert Opinion on Therapeutic Targets, 14 :1225-1245. [DOI] [Details]
Devitt, E,Lawless, MW,Sadlier, D,Browne, JA,Walsh, C,Crowe, J; (2010) 'Early viral and peripheral blood mononuclear cell responses to pegylated interferon and ribavirin treatment: the first 24 h'. European Journal of Gastroenterology and Hepatology, 22 :1211-1220. [DOI] [Details]
Ryan EJ, Dring M, Ryan CM, McNulty C, Stevenson NJ, Lawless MW, Crowe J, Nolan N, Hegarty JE, O'Farrelly C (2010) 'Variant in CD209 promoter is associated with severity of liver disease in chronic hepatitis C virus infection'. Human Immunology, 71 (8):829-832. [DOI] [Details]
Lawless MW (2010) 'Hemochromatosis protein HFE C282Y conformational considerations'. Journal of Hepatology, 52 (1):398-399. [DOI] [Details]
White M, Lawless MW, O'Dwyer MJ, Grealy R, Connell BO, Stordeur P, Kelleher D, McManus R, Ryan T (2010) 'Transforming growth factor beta-1 and interleukin-17 gene transcription in peripheral blood mononuclear cells and the human response to infection'. Cytokine, 50 (3):322-327. [DOI] [Details]
Norris S, White M, Mankan AK, Lawless MW (2010) 'Highly sensitivity adhesion molecules detection in hereditary haemochromatosis patients reveals altered expression'. International Journal, 37 (2):125-133. [DOI] [Details]
Gray SG, Crowe J, Lawless MW (2009) 'Hemochromatosis: as a conformational disorder'. International Journal of Biochemistry and Cell Biology, 41 (11):2094-2097. [DOI] [Details]
Lawless MW, O'Byrne KJ, Gray SG.; (2009) 'Oxidative stress induced lung cancer and COPD: opportunities for epigenetic therapy'. Journal of cellular and molecular medicine, 13 (9a):2800-2821. [Details]
Lawless, M. W.,Norris, S.,O'Byrne, K. J.,Gray, S. G.; (2009) 'Targeting histone deacetylases for the treatment of disease'. J Cell Mol Med, 13 (55):826-52826. Available Online [Details]
Lawless, M. W.,O'Byrne, K. J.,Gray, S. G.; (2009) 'Histone deacetylase inhibitors target diabetes via chromatin remodeling or as chemical chaperones?'. Curr Diabetes Rev, 5 (33):201-9201. Available Online [Details]
Mankan AK, Lawless MW, Gray SG, Kelleher D, McManus R. (2009) 'Nuclear Regulation: The Nuclear Response'. Journal of cellular and molecular medicine, . [Details]
Lawless MW, Norris S, O'Byrne KJ, Gray SG (2009) 'Targeting histone deacetylases for the treatment of immune, endocrine & metabolic disorders'. Endocrine, Metabolic and Immune Disorders - Drug Targets, 9 (1):84-107. [Details]
O'Dwyer MJ, Mankan AK, Ryan AW, Lawless MW, Stordeur P, Kelleher D, McManus R, Ryan T (2008) 'Characterization of tumour necrosis factor-alpha genetic variants and mRNA expression in patients with severe sepsis'. International Journal, 35 (4-5):279-285. [DOI] [Details]
White M, Mankan A, Lawless MW, O'Dwyer MJ, McManus R, Ryan T (2008) 'Mortality in humans with pneumonia and sepsis is related to an uncompensated anti-inflammatory response to infection'. Archives of Internal Medicine, 168 (13):1468-141. [DOI] [Details]
Lawless MW, Mankan AK, Gray SG, Norris S (2008) 'Endoplasmic reticulum stress--a double edged sword for Z alpha-1 antitrypsin deficiency hepatoxicity'. International Journal of Biochemistry and Cell Biology, 40 (8):1403-1414. [DOI] [Details]
O'Dwyer MJ, Mankan AK, White M, Lawless MW, Stordeur P, O'Connell B, Kelleher DP, McManus R, Ryan T (2008) 'The human response to infection is associated with distinct patterns of interleukin 23 and interleukin 27 expression'. Journal of Intensive Care Medicine, 34 (4):683-691. [DOI] [Details]
Lawless MW, Mankan AK, Ryan AW, Norris S (2008) 'Tauroursodeoxycholic acid: relieving the pathogenesis of HFE C282Y hereditary hemochromatosis'. Journal of Hepatology, 48 (1):344-345. [DOI] [Details]
Greene CM, Miller SD, Carroll T, McLean C, O'Mahony M, Lawless MW, O'Neill SJ, Taggart CC, McElvaney NG (2008) 'Alpha-1 antitrypsin deficiency: a conformational disease associated with lung and liver manifestations'. Journal of Inherited Metabolic Disease, 31 (1):21-34. [DOI] [Details]
Lawless MW, Mankan AK, Norris S (2008) 'Hereditary hemochromatosis should be considered a conformational disorder'. Medical Hypotheses, 70 (4):783-784. [DOI] [Details]
Lawless MW, White M, Mankan AK, O'Dwyer MJ, Norris S (2007) 'Elevated MCP-1 serum levels are associated with the H63D mutation and not the C282Y mutation in hereditary hemochromatosis'. Tissue Antigens, 70 (4):294-300. [DOI] [Details]
Lawless MW, Mankan AK, White M, O'Dwyer MJ, Norris S (2007) 'Expression of hereditary hemochromatosis C282Y HFE protein in HEK293 cells activates specific endoplasmic reticulum stress responses'. BMC Cell Biology, 8 . [DOI] [Details]
Miller SD, Greene CM, McLean C, Lawless MW, Taggart CC, O'Neill SJ, McElvaney NG (2007) 'Tauroursodeoxycholic acid inhibits apoptosis induced by Z alpha-1 antitrypsin via inhibition of Bad'. Journal of Hepatology, 46 (2):496-503. [DOI] [Details]
Mulgrew AT, Taggart CC, Lawless MW, Greene CM, Brantly ML, O'Neill SJ, McElvaney NG (2004) 'Z alpha1-antitrypsin polymerizes in the lung and acts as a neutrophil chemoattractant'. Chest, 125 (5):1952-1957. [Details]
Lawless MW, Greene CM, Mulgrew A, Taggart CC, O'Neill SJ, McElvaney NG (2004) 'Activation of endoplasmic reticulum-specific stress responses associated with the conformational disease Z alpha 1-antitrypsin deficiency'. Journal of Immunology, 172 (9):5722-5726. [Details]
Enright, M.R., Finnegan, M.M., McInerney, J., O'Laighleis, M., and Griffin, C.T (2001) 'Developments in entomopathogenic nematode, bacterial research'. Specific adherence of psorangia of a Paenibacillus sp. Bacterium to Heterohabditis spp. Nematodes: Hitching a ride to lunch?, :301-306. [Details]
   

Published Reports

Sinead Boyce, John Britton, Daithi O' Corrain, Alison Donnnelly, Margaret Fine-Davis, Abigal Ruth Freeman, Gemma Irvine, Avril Kennan, Matthew Lawless, Adriele Prina Mello, Tim Yeomans (2006) Contract Researchers in Trinity College Dublin: A Frontline Perspective. TRSA, Position Paper, Trinity College Dublin. [Details]
                                                                                       

Research

Research Interests

My main laboratory research interest is liver biochemistry and my group focuses particularly on hepatitis C infection and other central cofactors (particularly genetic) that may influence patient prognosis in the evolution of end stage events such as liver cancer. Together with a group of close collaborators both nationally and internationally this research has developed into an international research program with an established track record and interest in liver diseases in particular hepatitis C, hereditary haemochromatosis and the childhood liver cancer Z Alpha-1 antitryspin deficiency.                      

Research Projects

Sponsor : University College Dublin Foundation Ltd.
Title : Liver Cancer
Start Date / End Date : 04-OCT-13 / 14-DEC-15

Recent Postgraduates

Mr Jun Zhao, BSc, MSc