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researcher

Michaela Higgins

Clinical Professor

School of Medicine

Tel: 353 1 803 4447
Email: michaela.higgins@ucd.ie

Biography

Assistant Professor Harvard Medical School, Boston, USA 2010-2014

Attending Physician Massachusetts General Hospital, Boston, USA 2010-2014

 

Prof. Michaela Higgins has been a Consultant Medical Oncologist at the Mater Misericordiae University Hospital since 2015, with specialty interest in breast and lung cancers. Previous to this she was an Assistant Professor of Medicine at Harvard Medical School and an Attending (Consultant) Physician at Massachusetts General Hospital, Boston. Her cancer research has been awarded competitive funding by the U.S. Department of Defense, The Conquer Cancer Foundation and the Avon Foundation. Prof. Higgins has led numerous national and international clinical trials for patients with cancer. Her research has been awarded multiple competitive grants and she has over 40 manuscripts in peer-reviewed journals. Prof. Higgins is a member of Cancer Research UK¿s Clinical Trials Awards and Advisory Committee and the Mater Hospital Lung Cancer Working Group. She serves on the UCD Clinical Research Centre Executive Committee. 

UCD Medicine Research Individual Investigator 

Professional

Honours and Awards

Year: 2012.
Title: Career Development Award
Year: 2010.
Title: Merit Award
Year: 2009.
Title: Young Investigator Award
Year: 2002.
Title: First Class Honours in Medicine at Final MB Examination
Year: 2002.
Title: Sean Malone Medal in Psychiatry
Year: 2002.
Title: McCarthy Medal in Surgery
Year: 2002.
Title: Magennis Gold Medal in Clinical Medicine
Year: 2001.
Title: Tobin Prize in Surgery
Year: 2001.
Title: Dargan Prize in Medicine

Associations

Association: American Society of Clinical Oncology, Function/Role: Member
Association: Royal College of Physicians in Ireland, Function/Role: Member
       

Committees

Committee : UCD Clinical Research Centre Executive Committee
Committee : Mater Hospital Lung Cancer Working Group
             

Publications

     

Peer Reviewed Journals

Agarwal N, Machiels JP;Su¿¿rez C;Lewis N;Higgins M;Wisinski K;Awada A;Maur M;Stein M;Hwang A;Mosher R;Wasserman E;Wu G;Zhang H;Zieba R;Elmeliegy M (2016) 'Phase I Study of the Prolactin Receptor Antagonist LFA102 in Metastatic Breast and Castration-Resistant Prostate Cancer'. Oncologist, 21 (5):535-536. [DOI] [Details]
Chavarri-Guerra Y, Higgins MJ;Szymonifka J;Cigler T;Liedke P;Partridge A;Ligibel J;Come SE;Finkelstein D;Ryan PD;Goss PE (2014) 'Drug withdrawal in women with progressive metastatic breast cancer while on aromatase inhibitor therapy'. British Journal of Cancer, 111 (11):2046-2050. [DOI] [Details]
Sarangi S, Mosulpuria K;Higgins MJ;Bardia A (2014) 'The Evolving Role of Circulating Tumor Cells in the Personalized Management of Breast Cancer: from Enumeration to Molecular Characterization'. Current Breast Cancer Reports, 6 (3):146-153. [DOI] [Details]
Fathi AT, Sadrzadeh H;Comander AH;Higgins MJ;Bardia A;Perry A;Burke M;Silver R;Matulis CR;Straley KS;Yen KE;Agresta S;Kim H;Schenkein DP;Borger DR (2014) 'Isocitrate dehydrogenase 1 (IDH1) mutation in breast adenocarcinoma is associated with elevated levels of serum and urine 2-hydroxyglutarate'. Oncologist, 19 (6):602-607. [DOI] [Details]
Beaver JA, Jelovac D;Balukrishna S;Cochran RL;Croessmann S;Zabransky DJ;Wong HY;Valda Toro P;Cidado J;Blair BG;Chu D;Burns T;Higgins MJ;Stearns V;Jacobs L;Habibi M;Lange J;Hurley PJ;Lauring J;VanDenBerg DA;Kessler J;Jeter S;Samuels ML;Maar D;Cope L;Cimino-Mathews A;Argani P;Wolff AC;Park BH (2014) 'Detection of cancer DNA in plasma of patients with early-stage breast cancer'. Clinical Cancer Research, 20 (10):2643-2650. [DOI] [Details]
Higgins MJ, Liedke PE;Goss PE (2013) 'Extended adjuvant endocrine therapy in hormone dependent breast cancer: the paradigm of the NCIC-CTG MA.17/BIG 1-97 trial'. Critical Reviews in Oncology/Hematology, 86 (1):23-32. [DOI] [Details]
Higgins MJ, Jelovac D;Barnathan E;Blair B;Slater S;Powers P;Zorzi J;Jeter SC;Oliver GR;Fetting J;Emens L;Riley C;Stearns V;Diehl F;Angenendt P;Huang P;Cope L;Argani P;Murphy KM;Bachman KE;Greshock J;Wolff AC;Park BH (2012) 'Detection of tumor PIK3CA status in metastatic breast cancer using peripheral blood'. Clinical Cancer Research, 18 (12):3462-3469. [DOI] [Details]
Lee BL, Higgins MJ;Goss PE (2012) 'Denosumab and the current status of bone-modifying drugs in breast cancer'. Acta Oncologica, 51 (2):157-167. [DOI] [Details]
Higgins MJ, Baselga J (2011) 'Targeted therapies for breast cancer'. Journal of Clinical Investigation, 121 (10):3797-3803. [DOI] [Details]
Higgins MJ, Baselga J (2011) 'Breast cancer in 2010: Novel targets and therapies for a personalized approach'. Nature Reviews Clinical Oncology, 8 (2):65-66. [DOI] [Details]
Higgins MJ, Stearns V (2011) 'Pharmacogenetics of endocrine therapy for breast cancer'. Annual Review of Medicine, 62 :281-293. [DOI] [Details]
Schapira L, Higgins MJ (2011) 'All nodes lead to chemo'. Oncologist, 16 (5):722-725. [DOI] [Details]
                                                                                             

Research

Research Interests

Dr Higgins acts as local PI for several Cancer Trials Ireland clinical studies available for lung and breast cancer patients at the Mater hospital, Dublin. She also is leading a pilot exosome biomarker study in women with triple negative breast cancer which is being co-led with Dr. Amanda McCann in the Conway Institute

     

Collaborators

Internal Collaborators

Dr. Amanda McCann (Conway Institute, UCD)
 

External Collaborators

Cancer Trials Ireland