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Researchers at UCD

Michele Harrison

Senior Clinical Lecturer

School Of Medicine

Tel: +353 1 7166326
Email: mharrison@mater.ie

Publications

Books

Dervan, P, Harrison, M; (2004) Minds Maps in Pathology (Chinese translation). : Elsevier (Sinapore) Pte Ltd. [Details]
Dervan, P, Harrison, M,; (2002) Mind Maps in Pathology. : Churchill Livingstone. [Details]
   

Peer Reviewed Journals

Ma'ayeh M, Purandare N;Harrison M;Geary MP (2014) 'A rapidly enlarging cutaneous hemangioma in pregnancy'. Clinics and practice, 4 (2). [DOI] [Details]
92. PENPACT-1 (PENTA 9/PACTG 390) Study Team, A. Babiker, H. Castro nee Green H, A. Compagnucci, S. Fiscus, C. Giaquinto, DM. Gibb, L. Harper, L. Harrison, M. Hughes, R Mc Kinney, A. Melvin, L. Mofenson, Y. Saidi, ME. Smith, G. Tudor-Williams, AS. Walker. Collaborators J. Lambert et al. ; (2011) 'First-line antiretroviral therapy with a protease inhibitor versus non-nucleoside reverse transcriptase inhibitor and switch at higher versus low viral load in HIV-infected children: an open-label, randomised phase 2/3 trial'. The Lancet, . [Details]
Prencipe M, Fitzpatrick P, Gorman S, Tosetto M, Klinger R, Furlong F, Harrison M, O'Connor D, Roninson IB, O'Sullivan J, McCann A; (2009) 'Cellular senescence induced by aberrant MAD2 levels impacts on paclitaxel responsiveness in vitro'. British Journal of Cancer, 101 (11):1900-1908. [DOI] [Details]
Mc Cormack O, Chung WY, Fitzpatrick P, Cooke F, Flynn B, Harrison M, Fox E,Gallagher E, McGoldrick A, Dervan PA, McCann A, Kerin MJ.; (2008) 'Progesterone receptor B (PRB) promoter hypermethylation in sporadic breast cancer: Progesterone receptor B hypermethylation in breast cancer'. Breast Cancer Research and Treatment, 111 :45-53. [Details]
Mc Cormack, O., Chung, W. Y., Fitzpatrick, P., Cooke, F., Flynn, B., Harrison, M., Fox, E., Gallagher, E., Mc Goldrick, A., Dervan, P. A., Mc Cann, A., Kerin, M. J., ; (2008) 'Growth arrest-specific gene 6 expression in human breast cancer'. British Journal of Cancer, 98 (6):1141-1146. [DOI] [Details]
McCann A, Gallagher EM, O'Shea DM, Fitzpatrick P, Harrison M, Gilmartin B, Watson JA, Clarke T, Leonard MO, McGoldrick A, Meehan M, Watson C, Furlong F, O'Kelly P, Fitzpatrick JM, Dervan PA, O'Grady A, Kay EW, ; (2008) 'Recurrence of urothelial carcinoma of the bladder: a role for insulin-like growth factor-II loss of imprinting and cytoplasmic E-cadherin immunolocalization'. Clinical Cancer Research, 14 (21):6829-6838. [DOI] [Details]
Meehan, M.,Melvin, A.,Gallagher, E.,Smith, J.,McGoldrick, A.,Moss, C.,Goossens, S.,Harrison, M.,Kay, E.,Fitzpatrick, J.,Dervan, P.,Mc Cann, A.; (2007) 'Alpha-T-catenin (CTNNA3) displays tumour specific monoallelic expression in urothelial carcinoma of the bladder'. Genes Chromosomes Cancer, 46 (6):587-93. [Details]
McCormack.O, Chung.WY, Fitzpatrick.P, Cooke.F, Flynn.B, Harrison.M, Fox.E, Gallagher.E, McGoldrick.A, Dervan.PA, McCann.A and Kerin.MJ.; (2007) 'PROGESTERONE RECEPTOR B (PRB) PROMOTER HYPERMETHYLATION IN SPORADIC BREAST CANCER: PROGESTERONE RECEPTOR B HYPERMETHYLATION IN BREAST CANCER'. Breast Cancer Research and Treatment, . [Details]
Gallagher, E; Goldrick, AM; Chung, WY; Cormack, OM; Harrison, M; Kerin, M; Dervan, PA; Cann, AM; ; (2006) 'Gain of imprinting of SLC22A18 sense and antisense transcripts in human breast cancer'. Genomics, 88 (1):12-17. [Details]
Pedersen, I.S., Dervan, P.A., McGoldrick, A., Harrison, M., Ponchel, F., Speirs, V., Isaacs, J.D., Gorey, T., and McCann, A.; (2002) 'Promoter switch: a novel mechanism causing biallelic PEG1/MEST expression in invasive breast cancer'. Human Molecular Genetics, 11 (12). [Details]
Pedersen, I.S., Dervan, P.A., Broderick, D., Harrison, M., Miller, N., Delany, E., O'Shea, D., Costello, P., McGoldrick, A., Keating, G., Tobin, B., Gorey, T., and McCann, A.; (1999) 'Frequent loss of imprinting of PEG1/MEST in invasive breast cancer'. Cancer Research, 59 (21):5449-5451. [Details]
Fee, M; Tobin, B; Magee, H; Harrison, M; Gorey, T; Dervan, PA; ; (1996) 'Comparison of oestrogen receptor assessment in frozen and paraffin sections'. Pathology Research and Practice, 192 (9):919-924. [Details]
Harrison.M, Coyne.J.D, Gorey.T, Dervan.P.A.; (1996) 'Comparison of cytomorphological and architectural heterogeneity in mammographically detected ductal carcinoma in situ'. Histopathology, 28 :445-450. [Details]
Harrison.M, Magee.H, O'Loughlin.J, Gorey.T, Dervan.P.A.; (1995) 'Chromosome 1 aneusomy, identified by interphase cytogenetics, in mammographically detected ductal carcinoma in situ of the breast'. Journal of Pathology, 175 :303-309. [Details]
Vahdat, L.,Raptis, G.,Fennelly, D.,Hamilton, N.,Reich, L.,Tiersten, A.,Harrison, M.,Hudis, C.,Moore, M.,Yao, T. J.,Norton, L.,Crown, J.; (1995) 'Rapidly cycled courses of high-dose alkylating agents supported by filgrastim and peripheral blood progenitor cells in patients with metastatic breast cancer'. Clinical Cancer Research, 1 (11):1267-1273. Available Online [Details]
Gaffney.R, Harrison.M, Walsh.M, Sweeney.E, Cafferkey.M.; (1993) 'The incidence and role of actinomyces in recurrent acute tonsilitis'. Clinical Otolaryngology and Allied Sciences, 18 :268-271. [Details]
Crown, J.,Kritz, A.,Vahdat, L.,Reich, L.,Moore, M.,Hamilton, N.,Schneider, J.,Harrison, M.,Gilewski, T.,Hudis, C.,Gulati, S.,Norton, L.; (1993) 'Rapid Administration of Multiple Cycles of High-Dose Myelosuppressive Chemotherapy in Patients with Metastatic Breast-Cancer'. Journal of Clinical Oncology, 11 (6):1144-1149. Available Online [Details]
Doyle.YG, Harrison. M,O'Malley.F.; (1990) 'A study of selected death certificates from three Dublin teaching hospitals'. Public Health Medicine, 12 (2):118-123. [Details]
Harrison.M, Hourihane.DO'B; (1989) 'Quality assurance programme for necropsies'. Journal of Clinical Pathology, 42 (11):1190-1193. [Details]
 

Conference Publications

McGoldrick A, Harrison M, Fitzpatrick P, Dervan P, Kerin MJ.; (2006) Progesterone receptor B (PRB) targets Growth arrest specific gene 6 (Gas6) in primary breast cancer Association of Surgeons of Great Britain and Ireland edinburgh, , 03-MAY-06 [Details]
                       

Abstract

O'Reilly, EA,Furlong, F,Salman, R,Bambury, R,Harrison, M,Drew, G,Kelly, C,O'Grady, A,Kay, E,McCann, A,Kell, M (2012) Senescent and Autophagic cellular fates predict chemoresponse in TNBC. Abstract [Details]
Mccann, A,O'Shea, DM,Fitzpatrick, P,O'Grady, A,Harrison, M,O'Kelly, P,Gilmartin, B,Watson, C,Beasley, A,Fitzpatrick, JM,Dervan, PA,Kay, EW (2007) Cytoplasmic E-cadherin (cdh1) staining is an independent predictor of time to recurrence in bladder cancer. Abstract [Details]
Smith, JD,Meehan, M,McGoldrick, A,Harrison, M,McCormack, O,Dervan, P,Fitzpatrick, J,Kerin, M,McCann, A (2007) Alpha-T-catenin, a novel gene involved in cell adhesion, is structurally and epigenetically altered in breast cancer and not in lymph node deposits. Abstract [Details]
Harrison, M,Coyne, JD,Gorey, T,Dervan, T (1996) Heterogeneity of DCIS comparing cytonuclear and architectural classifications. Abstract [Details]
                                                               

Research

Research Interests

For my MD thesis entitled ‘Cytogenetic study of ductal carcinoma of the breast by in situ hybridisation interphase cytogenetics' I studied Ductal Carcinoma in Situ, classifying it and establishing the degree of heterogeneity shown. Using Interphase Cytogenetics, I assessed aneusomy in DCIS for chromosomes 1 and 17, comparing these findings to the histological classification. The aneusomy was compared to the ploidy status to confirm that it was not a reflection of an overall increase in chromosome complement.


I am the lead pathologist for a Conway Institute research group studying the mechanisms underlying Taxol resistance in breast cancer and also involved in the identification of novel indicators of disease progression in urothelial cell carcinoma of the bladder.


My involvement in both the breast and bladder cancer projects connects the ongoing projects in the Conway with the Mater Hospital. This includes accessing, pathological workup and histological grading and staging of all cases: to date a total of 400 breast carcinomas and 500 urothelial cell carcinomas have been studied. Evaluation also includes identifying areas for laser capture dissection microscopy (LCDM) and for coring for the construction of tissue microarray platforms.


FUNDING AGENCIES:
Mater College Grant
Cancer Research Ireland (CRI)

     

Collaborators

Internal Collaborators

Team:
Dr. Amanda McCann- amanda.mccann@ucd.ie  Senior Lecturer/Group leader
Dr. Breege Gilmartin- breege.gilmartin@ucd.ie  Lecturer/MD student
Mr. George Keatin- george.keating@ucd.ie  Senior technician
Mr. Alo McGoldrick- Aloysius.McGoldrick@ucd.ie  Senior technician
Dr. Jenny Orr- jenny.a.orr@ucd.ie  Post-doc
Ms. Maria Prencipe- maria.prencipe@ucd.ie   Post-grad
Ms. Barbara Flynn- barbara.flynn@maild.hse.ie  Post-grad
Ms.Emma Gallagher-gallagher_emma@yahoo.co.uk  Post-grad
Ms. Maria Meehan- maria.h.meehan@ucd.ie  Post-grad
Dr. James Smith- jamesdsmith@eircom.net  Post-grad