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Neil Gerard Docherty

Lecturer/Assistant Professor

Conway Institute of Biomolecular & Biomedical Research
UCD
Belfield
Dublin 4

Tel: Ext 6877
Email: neil.docherty@ucd.ie

Biography

Following undergraduate studies in Biochemistry and Immunology at University of Aberdeen, Scotland, I undertook a Ph.D. at The Department of Physiology and Pharmacology, University of Salamanca, Spain, studying inflammation and fibrosis in the setting of acute renal failure.

I subsequently undertook a post-doctoral fellowship at The School of Medicine at University College Dublin (UCD) examining functional, inflammatory and fibrotic aspects of renal injury in obstructive nephropathy. From 2007-2009, also at UCD, I led MD research projects focused on chronic inflammation and tissue remodelling in obstructive nephropathy, inflammatory bowel disease and glaucoma.

 In 2009, I was appointed to a lectureship at the Department of Physiology, Trinity College Dublin charged with the prospective design and implementation of Human Health & Disease an integrated 4-year programme of undergraduate study in applied biomedical science. In November 2013 I rejoined the UCD School of Medicine as a Lecturer in Pathology and Principal Investigator at the Diabetes Complications Research Centre where I co-lead research efforts in The Metabolic Medicine group into the surgical treatment of obesity, diabetes and diabetic complications with Professor Carel le Roux.

 
In June 2017 I was appointed to a permanent Faculty position in Anatomy and currently deliver teaching on the structure and function of the GI and GU tracts to students of Medicine, Biomedical Sciences, Radiography and Human Performance Science.

Professional

Honours and Awards

Year: 2012.
Title: Provost's special commendation for teaching excellence

Associations

Association: Royal Academy of Medicine in Ireland, Function/Role: Fellow
Association: European Association for the Study of Diabetes, Function/Role: Member
       

Committees

Committee : School of Medicine Admissions Committee
Committee : Animal Welfare Sub-Committee
Committee : Medicine Degree Committee 1

Employment

Employer: University of Gothenburg
Position: Visiting Researcher
           

Publications

 

Book Chapters

Neil G Docherty and John M Fitzpatrick; (2009) 'Upper Urinary Tract Obstruction' In: Mundy A, Fitzpatrick JM, Neal D and George JR (eds). The Scientific Basis of Urology 3rd Edition. London: Taylor and Francis. [Details]
Docherty NG, O'Connell PR; (2009) 'TNF a neutralization in the medical management of Crohn's Disease' In: Columbus F (eds). Tumour Necrosis Factor Alpha. New York: Nova Science. [Details]
 

Peer Reviewed Journals

Gorman DM, le Roux CW;Docherty NG (2016) 'The Effect of Bariatric Surgery on Diabetic Retinopathy: Good, Bad, or Both?'. Diabetes & metabolism journal, 40 (5):354-364. [DOI] [Details]
Neff KJ, Elliott JA;Corteville C;Abegg K;Boza C;Lutz TA;Docherty NG;le Roux CW (2016) 'Effect of Roux-en-Y gastric bypass and diet-induced weight loss on diabetic kidney disease in the Zucker diabetic fatty rat'. Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery, 13 (1):21-27. [DOI] [Details]
Nair M, le Roux CW;Docherty NG (2016) 'Mechanisms underpinning remission of albuminuria following bariatric surgery'. Current opinion in endocrinology, diabetes, and obesity, 23 (5):366-372. [DOI] [Details]
Elliott JA, le Roux CW, Reynolds J and Docherty NG (2016) 'Physiology, pathophysiology and therapeutic implications of enteroendocrine control of food intake'. Expert Review of Endocrinology and Metabolism, 11 (6):475-499. [DOI] [Details]
Docherty NG, F¿¿ndriks L;le Roux CW;Hallersund P;Werling M (2017) 'Urinary sodium excretion after gastric bypass surgery'. Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery, . [DOI] [Details]
Arora T, Seyfried F;Docherty NG;Tremaroli V;le Roux CW;Perkins R;B¿¿ckhed F (2017) 'Diabetes-associated microbiota in fa/fa rats is modified by Roux-en-Y gastric bypass'. The ISME journal, 11 (9):2035-2046. [DOI] [Details]
Abdelaal M, le Roux CW;Docherty NG (2017) 'Morbidity and mortality associated with obesity'. Annals of Translational Medicine, 5 (7). [DOI] [Details]
Kapoor N, Al-Najim W;le Roux CW;Docherty NG (2017) 'Shifts in Food Preferences After Bariatric Surgery: Observational Reports and Proposed Mechanisms'. Current obesity reports, . [DOI] [Details]
Docherty NG, le Roux CW (2016) 'Reconfiguration of the small intestine and diabetes remitting effects of Roux-en-Y gastric bypass surgery'. Current Opinion in Gastroenterology, 32 (2):61-66. [DOI] [Details]
Melvin, A. and le Roux, C.W. and Docherty, N.G. (2016) 'Which organ is responsible for the pathogenesis of obesity?'. Irish Medical Journal, 109 (4):397. Available Online [Details]
Maghsoodi N, Alaghband-Zadeh J;Cross G;Werling M;Fandriks L;Docherty NG;Olbers T;Dew T;Sherwood R;Vincent RP;Le Roux CW (2016) 'ANNALS EXPRESS: Elevated Fasting & Post-prandial C-Terminal Telopeptide (CTX) after Roux-en-Y gastric bypass (RYGB)'. Annals of Clinical Biochemistry, . [DOI] [Details]
Melvin A, le Roux CW;Docherty NG (2016) 'The Gut as an Endocrine Organ: Role in the Regulation of Food Intake and Body Weight'. Current Atherosclerosis Reports, 18 (8). [DOI] [Details]
Elliott JA, Docherty NG;Eckhardt HG;Doyle SL;Guinan EM;Ravi N;Reynolds JV;Roux CW (2016) 'Weight Loss, Satiety, and the Postprandial Gut Hormone Response After Esophagectomy: A Prospective Study'. Annals of Surgery, . [DOI] [Details]
Tham, J. C., le Roux, C. W., Docherty, N. G. (2015) 'Cardiovascular, renal and overall health outcomes after bariatric surgery'. Current Cardiology Reports, 17 (5):34. Available Online [Details]
Abegg K, Corteville C;Docherty NG;Boza C;Lutz TA;Mu¿¿oz R;le Roux CW (2015) 'Effect of bariatric surgery combined with medical therapy versus intensive medical therapy or calorie restriction and weight loss on glycemic control in Zucker diabetic fatty rats'. American journal of physiology. Regulatory, integrative and comparative physiology, 308 (4):1-9. [DOI] [Details]
Quill B, Irnaten M;Docherty NG;McElnea EM;Wallace DM;Clark AF;O'Brien CJ (2015) 'Calcium channel blockade reduces mechanical strain-induced extracellular matrix gene response in lamina cribrosa cells'. British Journal of Ophthalmology, 99 (7):1009-1014. [DOI] [Details]
Lavelle A, Lennon G, O'Sullivan O, Docherty N, Balfe A, Maguire A, Mulcahy HE, Doherty G, O'Donoghue D, Hyland J, Ross RP, Coffey JC, Sheahan K, Cotter PD, Shanahan F, Winter DC, O'Connell PR (2015) 'Spatial variation of the colonic microbiota in patients with ulcerative colitis and control volunteers'. Gut, . [DOI] [Details]
le Roux CW, Engstr¿¿m M;Bj¿¿rnfot N;F¿¿ndriks L;Docherty NG (2015) 'Equivalent Increases in Circulating GLP-1 Following Jejunal Delivery of Intact and Hydrolysed Casein: Relevance to Satiety Induction Following Bariatric Surgery'. Obesity Surgery, . [DOI] [Details]
Elliott JA, Jackson S;King S;McHugh R;Docherty NG;Reynolds JV;le Roux CW (2015) 'Gut Hormone Suppression Increases Food Intake After Esophagectomy With Gastric Conduit Reconstruction'. Annals of Surgery, 262 (5):824-830. [DOI] [Details]
Docherty NG, Le Roux CW (2015) 'Physiological adaptations following Roux-en-Y gastric bypass and the identification of targets for bariatric mimetic pharmacotherapy'. Current Opinion in Pharmacology, 25 :23-29. [DOI] [Details]
Docherty NG, Canney AL;le Roux CW (2015) 'Weight loss interventions and progression of diabetic kidney disease'. Current Diabetes Reports, 15 (8). [DOI] [Details]
Mazzei L, Docherty NG;Manucha W (2015) 'Mediators and mechanisms of heat shock protein 70 based cytoprotection in obstructive nephropathy'. Cell Stress and Chaperones, 20 (6):893-906. [DOI] [Details]
Abegg, K., Corteville, C., Docherty, N. G., Boza, C., Lutz, T. A., Munoz, R., le Roux, C. W. (2015) 'Effect of bariatric surgery combined with medical therapy versus intensive medical therapy or calorie restriction and weight loss on glycemic control in Zucker diabetic fatty rats'. American Journal of Physiology - Regulatory Integrative and Comparative Physiology, 308 (4):9. Available Online [Details]
Docherty, N. G., Canney, A. L., le Roux, C. W. (2015) 'Weight Loss Interventions and Progression of Diabetic Kidney Disease'. Current Diabetes Reports, 15 (8):625. Available Online [Details]
Lavelle, A., Lennon, G., O'Sullivan, O., Docherty, N., Balfe, A., Maguire, A., Mulcahy, H. E., Doherty, G., O'Donoghue, D., Hyland, J., Ross, R. P., Coffey, J. C., Sheahan, K., Cotter, P. D., Shanahan, F., Winter, D. C., O'Connell, P. R. (2015) 'Spatial variation of the colonic microbiota in patients with ulcerative colitis and control volunteers'. Gut, . Available Online [Details]
Quill, B., Irnaten, M., Docherty, N. G., McElnea, E. M., Wallace, D. M., Clark, A. F., O'Brien, C. J. (2015) 'Calcium channel blockade reduces mechanical strain-induced extracellular matrix gene response in lamina cribrosa cells'. British Journal of Ophthalmology, 99 (7):1009-14. Available Online [Details]
Vallon, V., Docherty, N. G. (2014) 'Intestinal regulation of urinary sodium excretion and the pathophysiology of diabetic kidney disease: a focus on glucagon-like peptide 1 and dipeptidyl peptidase 4'. Experimental Physiology, 99 (9):1140-5. Available Online [Details]
McElnea EM, Hughes E;McGoldrick A;McCann A;Quill B;Docherty N;Irnaten M;Farrell M;Clark AF;O'Brien CJ;Wallace DM (2014) 'Lipofuscin accumulation and autophagy in glaucomatous human lamina cribrosa cells'. BMC Ophthalmology, 14 :153. [DOI] [Details]
Lennon G, Balfe A, Bambury N, Lavelle A, Maguire A, Docherty NG, Coffey JC, Winter D, Sheahan K, O`Connell PR. (2014) 'Correlations between colonic crypt mucin chemotype, inflammatory grade and Desulfovibrio species in ulcerative colitis'. Colorectal Disease, 16 (5):1-9. [DOI] [Details]
Docherty NG, le Roux CW (2014) 'Improvements in the metabolic milieu following Roux-en-Y gastric bypass and the arrest of diabetic kidney disease'. Experimental Physiology, 99 (9):1146-1153. [DOI] [Details]
Vallon V, Docherty NG (2014) 'Intestinal regulation of urinary sodium excretion and the pathophysiology of diabetic kidney disease: a focus on glucagon-like peptide¿¿1 and dipeptidyl peptidase¿¿4'. Experimental Physiology, 99 (9):1140-1145. [DOI] [Details]
Docherty, N. G., le Roux, C. W. (2014) 'Physiological and pathophysiological signalling between the gut and the kidney: role in diabetic kidney disease'. Experimental Physiology, 99 (9):1138-9. Available Online [Details]
Docherty, N. G., le Roux, C. W. (2014) 'Improvements in the metabolic milieu following Roux-en-Y gastric bypass and the arrest of diabetic kidney disease'. Experimental Physiology, 99 (9):1146-53. Available Online [Details]
Docherty, N. G., Murphy, M., Martin, F., Brennan, E. P., Godson, C. (2014) 'Targeting cellular drivers and counter-regulators of hyperglycaemia- and transforming growth factor-beta1-associated profibrotic responses in diabetic kidney disease'. Experimental Physiology, 99 (9):1154-62. Available Online [Details]
Jackson, S., le Roux, C. W., Docherty, N. G. (2014) 'Bariatric surgery and microvascular complications of type 2 diabetes mellitus'. Current Atherosclerosis Reports, 16 (11):453. Available Online [Details]
Lennon, G., Balfe, A., Bambury, N., Lavelle, A., Maguire, A., Docherty, N. G., Coffey, J. C., Winter, D. C., Sheahan, K., O'Connell, P. R. (2014) 'Correlations between colonic crypt mucin chemotype, inflammatory grade and Desulfovibrio species in ulcerative colitis'. Colorectal Disease, 16 (5):9. Available Online [Details]
McElnea, E. M., Hughes, E., McGoldrick, A., McCann, A., Quill, B., Docherty, N., Irnaten, M., Farrell, M., Clark, A. F., O'Brien, C. J., Wallace, D. M. (2014) 'Lipofuscin accumulation and autophagy in glaucomatous human lamina cribrosa cells'. BMC Ophthalmology, 14 :153. Available Online [Details]
Rodriguez-Pena, A. B., Fuentes-Calvo, I., Docherty, N. G., Arevalo, M., Grande, M. T., Eleno, N., Perez-Barriocanal, F., Lopez-Novoa, J. M. (2014) 'Effect of angiotensin II and small GTPase Ras signaling pathway inhibition on early renal changes in a murine model of obstructive nephropathy'. BioMed Research International, 2014 :124902. Available Online [Details]
Irnaten M, Barry RC, Wallace DM, Docherty NG, Quill B, Clark AF, O'Brien CJ (2013) 'Elevated maxi-K(+) ion channel current in glaucomatous lamina cribrosa cells'. Eye, 115 :224-229. [DOI] [Details]
Lavelle A, Lennon G, Docherty N, Balfe A, Mulcahy HE, Doherty G, O Donoghue D, Hyland JM, Shanahan F, Sheahan K, Coffey JC, Winter DC, O Connell PR (2013) 'Depth-dependent differences in community structure of the human colonic microbiota in health'. PLoS ONE, 8 (11). [DOI] [Details]
Brennan EP, Nolan KA, Börgeson E, Gough OS, McEvoy CM, Docherty NG, Higgins DF, Murphy M, Sadlier DM, Ali-Shah ST, Guiry PJ, Savage DA, Maxwell AP, Martin F, Godson C (2013) 'Lipoxins attenuate renal fibrosis by inducing let-7c and suppressing TGFβR1'. Journal of the American Society of Nephrology : JASN, 24 (4):627-637. [DOI] [Details]
Corcoran JB, McCarthy S, Griffin B, Gaffney A, Bhreathnach U, Börgeson E, Hickey FB, Docherty NG, Higgins DF, Furlong F, Martin F, Godson C, Murphy M (2013) 'IHG-1 must be localised to mitochondria to decrease Smad7 expression and amplify TGF-β1-induced fibrotic responses'. Biochimica et biophysica acta, 1833 (8):1969-1978. [DOI] [Details]
Irnaten, M., Barry, R. C., Wallace, D. M., Docherty, N. G., Quill, B., Clark, A. F., O'Brien, C. J. (2013) 'Elevated maxi-K(+) ion channel current in glaucomatous lamina cribrosa cells'. Experimental Eye Research, 115 :224-9. Available Online [Details]
Corcoran, J. B., McCarthhttps://rms.ucd.ie/ufrs/!W_VA_PUB_BOOKCHAPTER.SHOWy, S., Griffin, B., Gaffney, A., Bhreathnach, U., Borgeson, E., Hickey, F. B., Docherty, N. G., Higgins, D. F., Furlong, F., Martin, F., Godson, C., Murphy, M. (2013) 'IHG-1 must be localised to mitochondria to decrease Smad7 expression and amplify TGF-beta1-induced fibrotic responses'. Biochimica et biophysica acta, 1833 (8):1969-78. Available Online [Details]
Brennan, E. P., Nolan, K. A., Borgeson, E., Gough, O. S., McEvoy, C. M., Docherty, N. G., Higgins, D. F., Murphy, M., Sadlier, D. M., Ali-Shah, S. T., Guiry, P. J., Savage, D. A., Maxwell, A. P., Martin, F., Godson, C., Genie Consortium (2013) 'Lipoxins attenuate renal fibrosis by inducing let-7c and suppressing TGFbetaR1'. Journal of the American Society of Nephrology : JASN, 24 (4):627-37. Available Online [Details]
Mazzei, L. J., Garcia, I. M., Altamirano, L., Docherty, N. G., Manucha, W. (2012) 'Rosuvastatin preserves renal structure following unilateral ureteric obstruction in the neonatal rat'. American Journal of Nephrology, 35 (2):103-13. Available Online [Details]
Rowan, F., Docherty, N. G., Murphy, M., Murphy, T. B., Coffey, J. C., O'Connell, P. R. (2011) 'Ileal pouch microbial diversity'. Ann Surg, 254 (4):70. Available Online [Details]
Hickey FB, Corcoran JB;Docherty NG;Griffin B;Bhreathnach U;Furlong F;Martin F;Godson C;Murphy M (2011) 'IHG-1 promotes mitochondrial biogenesis by stabilizing PGC-1¿¿'. Journal of the American Society of Nephrology : JASN, 22 (8):1475-1485. [DOI] [Details]
Burke JP, Cunningham MF, Sweeney C, Docherty NG, O'Connell PR; (2011) 'N-cadherin is overexpressed in Crohn's stricture fibroblasts and promotes intestinal fibroblast migration'. Inflammatory Bowel Diseases, 17 (8):1665-1673. [DOI] [Details]
Medani, M., Collins, D., Docherty, N.G., Baird, A.W., O'Connell, P.R., Winter, D.C.; (2011) 'Emerging role of hydrogen sulfide in colonic physiology and pathophysiology'. Inflammatory bowel diseases, 17 (7):1620-1625. [DOI] [Details]
Quill, B., Docherty, N. G., Clark, A. F., O'Brien, C. J. (2011) 'The effect of graded cyclic stretching on extracellular matrix-related gene expression profiles in cultured primary human lamina cribrosa cells'. Invest Ophthalmol Vis Sci, 52 (3):1908-15. Available Online [Details]
Medani, M., Collins, D., Docherty, N. G., Baird, A. W., O'Connell, P. R., Winter, D. C. (2011) 'Emerging role of hydrogen sulfide in colonic physiology and pathophysiology'. Inflamm Bowel Dis, 17 (7):1620-5. Available Online [Details]
McElnea, E. M., Quill, B., Docherty, N. G., Irnaten, M., Siah, W. F., Clark, A. F., O'Brien, C. J., Wallace, D. M. (2011) 'Oxidative stress, mitochondrial dysfunction and calcium overload in human lamina cribrosa cells from glaucoma donors'. Mol Vis, 17 :1182-91. Available Online [Details]
Hickey, F. B., Corcoran, J. B., Docherty, N. G., Griffin, B., Bhreathnach, U., Furlong, F., Martin, F., Godson, C., Murphy, M. (2011) 'IHG-1 promotes mitochondrial biogenesis by stabilizing PGC-1alpha'. J Am Soc Nephrol, 22 (8):1475-85. Available Online [Details]
Docherty, N. G., Godson, C. (2011) 'Fibrinogen as a damage-associated mitogenic signal for the renal fibroblast'. Kidney Int, 80 (10):1014-6. Available Online [Details]
Burke, J. P., Cunningham, M. F., Sweeney, C., Docherty, N. G., O'Connell, P. R. (2011) 'N-cadherin is overexpressed in Crohn's stricture fibroblasts and promotes intestinal fibroblast migration'. Inflamm Bowel Dis, 17 (8):1665-73. Available Online [Details]
Borgeson, E., Docherty, N. G., Murphy, M., Rodgers, K., Ryan, A., O'Sullivan, T. P., Guiry, P. J., Goldschmeding, R., Higgins, D. F., Godson, C. (2011) 'Lipoxin A(4) and benzo-lipoxin A(4) attenuate experimental renal fibrosis'. FASEB J, 25 (9):2967-79. Available Online [Details]
Rowan, F., Docherty, N. G., Murphy, M., Murphy, T. B., Coffey, J. C., O'Connell, P. R. (2010) 'Bacterial colonization of colonic crypt mucous gel and disease activity in ulcerative colitis'. Ann Surg, 252 (5):869-75. Available Online [Details]
Rowan F, Docherty NG;Murphy M;Murphy TB;Coffey JC;O'Connell PR (2010) 'Bacterial colonization of colonic crypt mucous gel and disease activity in ulcerative colitis'. Annals of Surgery, 252 (5):869-875. [DOI] [Details]
Medani M, Collins D, Docherty NG, Baird AW, O'Connell PR, Winter DC; (2010) 'Emerging role of hydrogen sulfide in colonic physiology and pathophysiology'. Inflammatory Bowel Diseases, . [DOI] [Details]
Burke JP, Watson RW, Mulsow JJ, Docherty NG, Coffey JC, O'Connell PR; (2010) 'Endoglin negatively regulates transforming growth factor beta1-induced profibrotic responses in intestinal fibroblasts'. British Journal of Surgery, 97 (6):892-901. [DOI] [Details]
Burke JP, Cunningham MF, Watson RW, Docherty NG, Coffey JC, O'Connell PR; (2010) 'Bacterial lipopolysaccharide promotes profibrotic activation of intestinal fibroblasts'. British Journal of Surgery, 97 (7):1126-1134. [DOI] [Details]
Rowan, F., Docherty, N. G., Murphy, M., Murphy, B., Calvin Coffey, J., O'Connell, P. R. (2010) 'Desulfovibrio bacterial species are increased in ulcerative colitis'. Dis Colon Rectum, 53 (11):1530-6. Available Online [Details]
Quinlan, M. R., Cronin, P., Daly, P. J., Watson, R. W., Manucha, W., Docherty, N. G., Fitzpatrick, J. M. (2010) 'A gender comparison of postobstructive injury in the rat kidney'. Kidney Blood Press Res, 33 (4):266-73. Available Online [Details]
Cunningham, M. F., Docherty, N. G., Coffey, J. C., Burke, J. P., O'Connell, P. R. (2010) 'Postsurgical recurrence of ileal Crohn's disease: an update on risk factors and intervention points to a central role for impaired host-microflora homeostasis'. World J Surg, 34 (7):1615-26. Available Online [Details]
Cunningham, M. F., Docherty, N. G., Burke, J. P., O'Connell, P. R. (2010) 'S100A4 expression is increased in stricture fibroblasts from patients with fibrostenosing Crohn's disease and promotes intestinal fibroblast migration'. Am J Physiol Gastrointest Liver Physiol, 299 (2):66. Available Online [Details]
Burke, J. P., Watson, R. W., Mulsow, J. J., Docherty, N. G., Coffey, J. C., O'Connell, P. R. (2010) 'Endoglin negatively regulates transforming growth factor beta1-induced profibrotic responses in intestinal fibroblasts'. Br J Surg, 97 (6):892-901. Available Online [Details]
Burke, J. P., Cunningham, M. F., Watson, R. W., Docherty, N. G., Coffey, J. C., O'Connell, P. R. (2010) 'Bacterial lipopolysaccharide promotes profibrotic activation of intestinal fibroblasts'. Br J Surg, 97 (7):1126-34. Available Online [Details]
Rowan, F. E.,Docherty, N. G.,Coffey, J. C.,O'Connell, P. R.; (2009) 'Sulphate-reducing bacteria and hydrogen sulphide in the aetiology of ulcerative colitis'. Br J Surg, 96 (22):151-8151. Available Online [Details]
Rowan, F. E., Docherty, N. G., Coffey, J. C., O'Connell, P. R. (2009) 'Sulphate-reducing bacteria and hydrogen sulphide in the aetiology of ulcerative colitis'. Br J Surg, 96 (2):151-8. Available Online [Details]
Docherty, N. G., Calvo, I. F., Quinlan, M. R., Perez-Barriocanal, F., McGuire, B. B., Fitzpatrick, J. M., Watson, R. W. (2009) 'Increased E-cadherin expression in the ligated kidney following unilateral ureteric obstruction'. Kidney Int, 75 (2):205-13. Available Online [Details]
Daly, P. J., Docherty, N. G., Healy, D. A., McGuire, B. B., Fitzpatrick, J. M., Watson, R. W. (2009) 'The single insult of hypoxic preconditioning induces an antiapoptotic response in human proximal tubular cells, in vitro, across cold storage'. BJU International, 103 (2):254-259. Available Online [DOI] [Details]
Coffey, J. C.,Rowan, F.,Burke, J.,Dochery, N. G.,Kirwan, W. O.,O'Connell, P. R.; (2009) 'Pathogenesis of and unifying hypothesis for idiopathic pouchitis'. Am J Gastroenterol, 104 (44):1013-231013. Available Online [Details]
Coffey, J. C., Rowan, F., Burke, J., Dochery, N. G., Kirwan, W. O., O'Connell, P. R. (2009) 'Pathogenesis of and unifying hypothesis for idiopathic pouchitis'. Am J Gastroenterol, 104 (4):1013-23. Available Online [Details]
Coffey, J. C., Docherty, N. G., O'Connell, P. R. (2009) 'Hydrogen sulphide: an increasing need for scientific equipoise'. Gastroenterology, 137 (6):2181. Available Online [Details]
Burke, J. P., Watson, R. W., Murphy, M., Docherty, N. G., Coffey, J. C., O'Connell, P. R. (2009) 'Simvastatin impairs smad-3 phosphorylation and modulates transforming growth factor beta1-mediated activation of intestinal fibroblasts'. Br J Surg, 96 (5):541-51. Available Online [Details]
Quinlan, M. R., Docherty, N. G., Watson, R. W., Fitzpatrick, J. M. (2008) 'Exploring mechanisms involved in renal tubular sensing of mechanical stretch following ureteric obstruction'. Am J Physiol Renal Physiol, 295 (1). Available Online [Details]
Murphy, M., Docherty, N. G., Griffin, B., Howlin, J., McArdle, E., McMahon, R., Schmid, H., Kretzler, M., Droguett, A., Mezzano, S., Brady, H. R., Furlong, F., Godson, C., Martin, F. (2008) 'IHG-1 amplifies TGF-beta1 signaling and is increased in renal fibrosis'. J Am Soc Nephrol, 19 (9):1672-80. Available Online [Details]
Burke, J. P., Ferrante, M., Dejaegher, K., Watson, R. W., Docherty, N. G., De Hertogh, G., Vermeire, S., Rutgeerts, P., D'Hoore, A., Penninckx, F., Geboes, K., Van Assche, G., O'Connell, P. R. (2008) 'Transcriptomic analysis of intestinal fibrosis-associated gene expression in response to medical therapy in Crohn's disease'. Inflamm Bowel Dis, 14 (9):1197-204. Available Online [Details]
McGuire, B. B., Watson, R. W., Perez-Barriocanal, F., Fitzpatrick, J. M., Docherty, N. G. (2007) 'Gender differences in the renin-angiotensin and nitric oxide systems: relevance in the normal and diseased kidney'. Kidney Blood Press Res, 30 (2):67-80. Available Online [Details]
Docherty, N. G., Morales, A. I., Lopez Novoa, J. M., Perez Barriocanal, F. (2007) '[The transition of epithelial cells to fibromyoblasts. Mechanisms involved and its possible relationship with renal fibrosis]'. Nefrologia, 27 (6):681-8. Available Online [Details]
Burke, J. P., Mulsow, J. J., O'Keane, C., Docherty, N. G., Watson, R. W., O'Connell, P. R. (2007) 'Fibrogenesis in Crohn's disease'. Am J Gastroenterol, 102 (2):439-48. Available Online [Details]
Healy, D. A., Daly, P. J., Docherty, N. G., Murphy, M., Fitzpatrick, J. M., Watson, R. W. (2006) 'Heat shock-induced protection of renal proximal tubular epithelial cells from cold storage and rewarming injury'. J Am Soc Nephrol, 17 (3):805-12. Available Online [Details]
Docherty, N. G., O'Sullivan, O. E., Healy, D. A., Murphy, M., O'Neill A, J., Fitzpatrick, J. M., Watson, R. W. (2006) 'TGF-beta1-induced EMT can occur independently of its proapoptotic effects and is aided by EGF receptor activation'. Am J Physiol Renal Physiol, 290 (5):12. Available Online [Details]
Docherty, N. G., O'Sullivan, O. E., Healy, D. A., Fitzpatrick, J. M., Watson, R. W. (2006) 'Evidence that inhibition of tubular cell apoptosis protects against renal damage and development of fibrosis following ureteric obstruction'. Am J Physiol Renal Physiol, 290 (1):13. Available Online [Details]
Docherty, N. G., Lopez-Novoa, J. M., Arevalo, M., Duwel, A., Rodriguez-Pena, A., Perez-Barriocanal, F., Bernabeu, C., Eleno, N. (2006) 'Endoglin regulates renal ischaemia-reperfusion injury'. Nephrol Dial Transplant, 21 (8):2106-19. Available Online [Details]
Prieto, M., Rodriguez-Pena, A. B., Duwel, A., Rivas, J. V., Docherty, N., Perez-Barriocanal, F., Arevalo, M., Vary, C. P., Bernabeu, C., Lopez-Novoa, J. M., Eleno, N. (2005) 'Temporal changes in renal endoglin and TGF-beta1 expression following ureteral obstruction in rats'. J Physiol Biochem, 61 (3):457-67. Available Online [Details]
Rodriguez-Pena, A., Eleno, N., Duwell, A., Arevalo, M., Perez-Barriocanal, F., Flores, O., Docherty, N., Bernabeu, C., Letarte, M., Lopez-Novoa, J. M. (2002) 'Endoglin upregulation during experimental renal interstitial fibrosis in mice'. Hypertension, 40 (5):713-20. Available Online [Details]
Docherty, N. G., Perez-Barriocanal, F., Balboa, N. E., Lopez-Novoa, J. M. (2002) 'Transforming growth factor-beta1 (TGF-beta1): a potential recovery signal in the post-ischemic kidney'. Ren Fail, 24 (4):391-406. Available Online [Details]

Other Journals

Rowan, F., Docherty, N.G., Murphy, M., Murphy, T.B., Coffey, J.C. and O'Connell, P.R.; (2010) 'Desulfovibrio bacterial species are increased in ulcerative colitis' Diseases of the Colon and Rectum 53 (4) :541-541. [Details]
Rowan F., Docherty N.G., Murphy M., Murphy T.B., Coffey J.C., O'Connell P.R. (2011) 'Ileal pouch microbial diversity' Annals of Surgery 254 (4) :669-670. [DOI] [Details]
     

Editorial

Nair M, le Roux CW;Docherty NG (2016) Measuring changes in renal function after bariatric surgery: Why estimated glomerular filtration rate is not good enough. Editorial [DOI] [Details]
                                                                                                           

Research

Research Interests

In collaboration with my colleague Professor Carel le Roux, I co-lead research into the surgical treatment of obesity, diabetes and diabetic complications.

My current research focus centres on the pathophysiology and surgical management of progressive kidney disease in patients with obesity and type 2 diabetes. I have specific interests in the role of circulating soluble TNFR1 as a predictive marker of the incidence and progression of albuminuria and in the role of restoration of podocyte function in the resolutionary effects of bariatric surgery. 

UCD Medicine Research Centre: Diabetes Complications 
 

Research Projects

Sponsor : University College Dublin (UCD)
Title : OBRSS Research Support Scheme
Start Date / End Date : 01-NOV-16 / 31-OCT-19
Sponsor : Health Research Board (HRB)
Title : Effect of Bariatric Surgery on plasma TNFR1: A Risk Marker for Progressive Diabetic Kidney Disease
Start Date / End Date : 05-JUN-17 / 31-JUL-17
Sponsor : Enterprise Ireland (EI)
Title : "Open Science" Training Network in Cardiovascular & Renal Disease (OSCAR)
Start Date / End Date : 24-MAY-17 / 23-FEB-18
Sponsor : Food for Health Ireland - FHI2 UCD
Title : FHI-2
Start Date / End Date : 03-MAR-15 / 31-AUG-18
Sponsor : University College Dublin (UCD)
Title : Soluble TNFR1 as a Predictor of Diabetic Kidney Disease in Obesity and a Potential Tool for Guiding Clincal Decisions and Resource Allocation: Preliminary Interrogation in The Swedish Obese Subjects (SOS) Study Dataset
Start Date / End Date : 01-APR-14 / 30-SEP-15
Sponsor : The Wellcome Trust (WT)
Title : Effect of Roux-en-Y Gastric Bypass Surgery on Renal Macrophage Phenotype in Zucker Diabetic Fatty Rats
Start Date / End Date : 02-JUN-14 / 31-JUL-14
Sponsor : University College Dublin (UCD)
Title : Start-up Funds
Start Date / End Date : 01-MAR-14 / 28-FEB-17
Sponsor : University College Dublin Foundation Ltd.
Title : Research Activities
Start Date / End Date : 01-NOV-14 / 30-JUN-18
Sponsor : Health Research Board (HRB)
Title : Attenuation of Exaggerated Post-Prandial Gut Hormone Response: A Novel Therapeutic Strategy for the Treatment of Excessive Weight Loss Among Disease-Free Post-Oesophagectomy Patients
Start Date / End Date : 07-JUL-15 / 06-JUL-18

Recent Postgraduates

Current

M Nair

N Kapoor

C Murphy

P Sinclair


JElliott                              

A Doody

 

Previous

D Gorman
 
D diCapua
 
A Canney
 
S Jackson
 
K Neff
 
B Quill
 
M Cunningham,
 
F Rowan,
MR Quinlan,
 
O O¿Sullivan
 
B McGuire

 

 

 

Diabetic Kidney Disease

Bariatric Surgery

Oesophageal Cancer 

Metabolic Surgery 


Oesophageal Cancer 

Diabetic Kidney Disease

 

 

  Diabetic Retinopathy
 
Haemochromatosis
 
Diabetic Kidney Disease  Diabetic Kidney Disease  Diabetic Kidney Disease  Glaucoma
 
Crohn's Disease
 
Ulcerative colitis
 
Obstruct. nephropathy
 
Obstruct. nephropathy
 
Obstruct. nephropathy

                                      

  *Principal Supervisor

**Co-Supervisor

&Thesis in correction

 

 

 

 

 

PhD*

PhD**
 
 
PhD**
 
 
PhD**
 
 
PhD */&
 
 
M.Sc (Res) */&

 

 

 
M.Sc (Res) (09/17)*
 
M.Sc (Res) (09/17)*
 
M.D. (06/17)*
 
M.Sc (Res) (11/16)*
 
PhD (03/16)*
 
M.D. (03/12)**
 
M.D. (08/11)**
 
M.D. (06/09)**
 
M.D. (02/06)*  
 
M.Ch. 05/08)**
 
M.D. (12/07)*

 

 

 

 



















Current Postgraduate Students

Piriyah Sinclair, Doctor of Philosophy (PhD)   -   Thesis Co-Supervisor
Conor Murphy, Master of Science (MSc)   -   Thesis Co-Supervisor
Dora Gorman, Medicine (MB BCh BAO)   -   Secondary Supervisor
Alison Doody, Master of Science (MSc)   -   Thesis Supervisor
Natasha Kapoor, Doctor of Philosophy (PhD)   -   Thesis Co-Supervisor
Aisling Mangan, Master of Science (MSc)   -   Thesis Supervisor
Daniele-Mario Di Capua, Master of Science (MSc)   -   Thesis Supervisor
Meera Nair, Doctor of Philosophy (PhD)   -   Thesis Supervisor

Collaborators

Internal Collaborators

Professor Carel le Roux

Professor Catherine Godson

Dr. Aurelie Fabre


 
 

 

External Collaborators

Dr Walter Manucha (Universidad Nacional de Cuyo, Argentina)

Dr. Lars Fandriks (University of Gothenburg)

Professor Ian Megson and Phil  Wakemore (University of the Highlands and Islands, Scotland)