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Silke Ryan

Adjunct Clinical Associate Professor

School Of Medicine
Conway Institute
Belfield
Dublin 4

Tel: 01-2213702
Email: silke.ryan@ucd.ie

Biography

Current Employment
 

01¿17 ¿ date:                Consultant in Respiratory and Sleep Medicine, St. Vincent¿s University Hospital and Mater Misericordiae Hospital, Dublin

10¿17 ¿ date:                Associate Clinical Professor, School of Medicine


 Academic Qualifications

M.D., PhD, MRCPI

 Publication Summary

48 peer-reviewed papers

11 book chapters

2704 citations

H-index: 23
 
Grants 
 

¿ Health Research Board (Principal Investigator): Targeting Adipose Tissue Inflammation by Intermittent Hypoxia: Towards Personalized Medicine in Obstructive Sleep Apnoea, 2017-2020. ¿ 745,209
¿ Health Research Board (Principal Investigator): The role of adipose tissue in systemic inflammation in response to intermittent hypoxia and the importance of these events in the development of atherosclerosis; 2012-2016. ¿ 516,946
¿ UCD Seed Funding (Principal Investigator): Signalling mechanisms of intermittent hypoxia-induced atherosclerosis; 2013-2015. ¿ 15,000
¿ Health Research Board (Co-investigator ¿ PI Prof Walter McNicholas): Mechanisms of non-dipping hypertension in obstructive sleep apnoea; 2012-2015. ¿ 230,000


Awards


 Year: 2015
Title: Cournand Lecturer Award, European Respiratory Society (recognizes the most successful young European investigator in the broad field of Respiratory Medicine over a 3-year period)
Year: 2012
Title: James B. Skatrud New Investigator Award, American Thoracic Society (recognizes outstanding career accomplishments and future promise of a new investigator working in the area of respiratory neurobiology and sleep, awarded annually)

Professional

Honours and Awards

Year: 2015.
Title: Cournand Lecture Award
Year: 2012.
Title: James Skatrud New Investigator Award
Year: 2006.
Title: European Respiratory Society Travel Grant for Sleep Medicine

Associations

Association: European Sleep Research Society, Function/Role: Member
Association: Journal of Sleep Research, Function/Role: Associate Editor
Association: European Sleep Research Society, Function/Role: Member
Association: Irish Sleep Society, Function/Role: Committee Member
Association: Irish Thoracic Society, Function/Role: Member
Association: European Respiratory Society, Function/Role: Member
Association: American Thoracic Society, Function/Role: Member
     

Conference Contributions

Ryan, S (2015) Inflammatory pathway activation by intermittent hypoxia in obstructive sleep apnoea. [Invited Lecture], Conway Festival, Conway Institute, UCD, Dublin , 10-SEP-15 - 10-SEP-15.
Ryan, S (2015) Intermittent hypoxia and adipose tissue. [Invited Lecture], Sleep and Breathing Conference, Barcelona, Spain , 17-APR-15 - 17-APR-15.
Ryan, S (2015) Obstructive sleep apnoea as a cause of cardiovascular disease. [Invited Lecture], Sleep and Breathing Conference, Barcelona, Spain , 17-APR-15 - 17-APR-15.
Ryan, S (2015) Ring of fire: Inflammation and metabolism in sleep-disordered breathing. [Oral Presentation], European Respiratory Society Annual Congress, Amsterdam, Netherlands , 26-SEP-15 - 30-SEP-15.
Ryan, S (2015) Inflammatory pathway activation by intermittent hypoxia in obstructive sleep apnoea. [Keynote Address], European Respiratory Society Annual Congress, Amsterdam, Netherlands , 26-SEP-15 - 30-SEP-15.
   

Education

Year 2007 Institution: UCD
Qualification: PhD Subject: Medicine
Year 1999 Institution: Friedrich-Schiller University, Jena, Germany
Qualification: MD Subject: Medicine
Year 2003 Institution: RCPI
Qualification: MRCPI Subject: Medicine
Year 2010 Institution: European Respiratory Society
Qualification: Diploma Subject: Respiratory Medicine (HERMES)
Year 1998 Institution: Friedrich-Schiller University, Jena, Germany
Qualification: MBChB Subject: Medicine
 

Consultancy

Client: St Vincent's University Hospital and Mater Misericordiae Hospital
 

Journals Edited

Journal Of Sleep Research: Editor.
Sleep Medicine: Reviewer.
Respirology: Reviewer.
Sleep: Reviewer.
Respiration: Reviewer.
Sleep And Breathing: Reviewer.
Journal Of Applied Physiology: Reviewer.
Thorax: Reviewer.
European Respiratory Monograph: Reviewer.
European Respiratory Journal: Reviewer.
American Journal Of Cardiology: Reviewer.
 

Publications

 

Book Chapters

Ryan S. (2017) 'Obstructive Sleep Apnea' In: Quah, S.R. and Cockerham, W.C (eds). The International Encyclopedia of Public Health, 2nd edition. Amsterdam: Elsevier. [Details]
Ryan S, McNicholas WT (2015) 'Obstructive Sleep Apnea and Other Respiratory Disorders in Obesity' In: Ahima RS (eds). Metabolic Syndrome. A comprehensive textbook. Switzerland: Springer. [Details]
Ryan S. (2014) 'Obstructive sleep apnoea' In: Caplan M (eds). Reference Module in Biomedical Sciences. Amsterdam: Elsevier. [Details]
Ryan S, McNicholas WT (2012) 'Sleep history' In: Anita Simonds, Wilfried De Backer (eds). ERS Handbook Respiratory Sleep Medicine. Lausanne: ERS. [Details]
Ryan S, McNicholas WT. (2012) 'Nasal pillows as an alternative interface in patients with obstructive sleep apnoea syndrome initiating continuous positive airway pressure therapy' In: Teofilo Lee-Cheong (eds). Best of Sleep Medicine 2012. North Charleston, USA: CreateSpace Independent Publishing Platform. [Details]
Ryan S, McNicholas WT. (2011) 'Effect of Salmeterol on Sleeping Oxygen Saturation in Chronic Obstructive Pulmonary Disease' In: Teofilo Lee-Cheong (eds). Best of Sleep Medicine 2011. North Charleston, USA: CreateSpace Independent Publishing Platform. [Details]
Ryan S, Doherty LS, Nolan GM, McNicholas WT (2010) 'Effect of heated humidification and topical steroids in patients with obstructive sleep apnea syndrome using nasal continuous positive airway pressure' In: Teofilo Lee-Cheong (eds). Best of Sleep Medicine 2010. North Charleston, USA: CreateSpace Independent Publishing Platform. [Details]
Wuyts WA, Ryan S, Egan JJ. (2009) 'Pulmonary Fibrosis' In: A.J. Fisher, G.M. Verleden, and G. Massard (eds). Lung Transplantation. Lausanne: European Respiratory Monograph. [Details]
Garvey J, Ryan S, McNicholas WT. (2009) 'Oxidative stress, inflammation, and vascular function in obstructive sleep apnea syndrome' In: TD Bradley, JS Floras (eds). Sleep Apnea: Implications in Cardiovascular and Cerebrovascular Disease, 2nd Edition. Danvers: CRC Press. [Details]
Ryan S, McNicholas WT. (2008) 'Obstructive sleep apnea' In: Kris Heggenhougen and Stella Quah (eds). International Encyclopedia of Public Health. San Diego, USA: Academic Press. [Details]
de Chazal P, Heneghan C, Chua CP, Shouldice R, Ryan S, McNicholas W. (2007) 'Home- Based Assessment of Sleep Apnoea using Simultaneous Electrocardiogram and Oximetry Signals' In: Robert T. Ferber (eds). Progress in Sleep Apnea Research. New York, USA: Nova Science Publishers. [Details]
 

Peer Reviewed Journals

Murphy AM, Thomas A, Crinion SJ, Kent BD, Tambuwala MM, Fabre A, Pepin JL, Roche HM, Arnaud C, Ryan S. (2017) 'Intermittent hypoxia in obstructive sleep apnoea mediates insulin resistance through adipose tissue inflammation'. European Respiratory Journal, . [DOI] [Details]
Murphy DJ, Crinion SJ, Redmond CE, Healy GM, McNicholas WT, Ryan S, Dodd JD (2017) 'Diagnostic accuracy of carotid intima media thickness in predicting coronary plaque burden on coronary computed tomography angiography in patients with obstructive sleep apnoea'. Journal of Cardiovascular Computed Tomography, . [Details]
Crinion SJ, Ryan S, McNicholas WT. (2017) 'Obstructive sleep apnoea as a cause of nocturnal nondipping blood pressure: recent evidence regarding clinical importance and underlying mechanisms'. European Respiratory Journal, . [Details]
Puttappa A, Sheshadri K, Fabre A, Imberger G, Boylan J, Ryan S, Iqbal M, Conlon N. (2017) 'Prolonged Unexplained Hypoxemia as Initial Presentation of Cirrhosis: A Case Report'. American Journal of Case Reports, . [Details]
McNicholas WT, Bonsignore MR, Lévy P, Ryan S. (2016) 'Mild obstructive sleep apnoea: clinical relevance and approaches to management'. The Lancet Respiratory Medicine, . [Details]
Ryan S. (2016) 'Adipose tissue inflammation by intermittent hypoxia: mechanistic link between obstructive sleep apnoea and metabolic dysfunction'. Journal of Physiology, . [Details]
Marrone O, Battaglia S, Steiropoulos P, Basoglu OK, Kvamme JA, Ryan S, Pepin JL, Verbraecken J, Grote L, Hedner J, Bonsignore MR; ESADA study group.. (2016) 'Chronic kidney disease in European patients with obstructive sleep apnea: the ESADA cohort study'. Journal of Sleep Research, . [Details]
Vgontzas AN, Gaines J, Ryan S, McNicholas WT. (2016) 'CrossTalk proposal: Metabolic syndrome causes sleep apnoea'. Journal of Physiology, . [Details]
Kent BD, McNicholas WT, Ryan S. (2015) 'Insulin resistance, glucose intolerance and diabetes mellitus in obstructive sleep apnoea'. Journal of Thoracic Disease, 7 (8):1343-1357. [DOI] [Details]
Kent BD, Grote L, Ryan S, Pépin JL, Bonsignore MR, Tkacova R, Saaresranta T, Verbraecken J, Lévy P, Hedner J, McNicholas WT (2014) 'Diabetes mellitus prevalence and control in sleep-disordered breathing: the European Sleep Apnea Cohort (ESADA) study'. Chest, 146 (4):982-990. [Details]
Ryan S, Crinion SJ, McNicholas WT (2014) 'Obesity and sleep-disordered breathing--when two 'bad guys' meet'. Quarterly Journal of Medicine, 107 (12):949-954. [Details]
Taylor CT, Kent BD, Crinion SJ, McNicholas WT, Ryan S (2014) 'Human adipocytes are highly sensitive to intermittent hypoxia induced NF-kappaB activity and subsequent inflammatory gene expression'. Biochemical and Biophysical Research Communications, 447 (4):660-665. [Details]
Ryan S (2013) 'The effect of continuous positive airway pressure therapy on vascular function in obstructive sleep apnea: how much is enough?'. Sleep Medicine, . [Details]
Kent BD, Garvey JF;Ryan S;Nolan G;Dodd JD;McNicholas WT (2013) 'Severity of obstructive sleep apnoea predicts coronary artery plaque burden: a coronary computed tomographic angiography study'. European Respiratory Journal, 42 (5):1263-1270. [DOI] [Details]
Lévy P, Ryan S, Oldenburg O, Parati G (2013) 'Sleep Apnea and the Heart'. European respiratory review : an official journal of the European Respiratory Society, . [Details]
McSharry DG, Ryan S;Calverley P;Edwards JC;McNicholas WT (2012) 'Sleep quality in chronic obstructive pulmonary disease'. Respirology, 17 (7):1119-1124. [DOI] [Details]
Ryan, S,Garvey, JF,Swan, V,Behan, R,McNicholas, WT; (2011) 'Nasal pillows as an alternative interface in patients with obstructive sleep apnoea syndrome initiating continuous positive airway pressure therapy'. Journal of Sleep Research, 20 :367-373. [DOI] [Details]
Kent BD, Ryan S, McNicholas WT (2011) 'Obstructive sleep apnea and inflammation: relationship to cardiovascular co-morbidity'. Respiratory Physiology and Neurobiology, 178 (3):475-481. [DOI] [Details]
Kent BD, Ryan S, McNicholas WT; (2010) 'The genetics of obstructive sleep apnoea'. Current opinion in pulmonary medicine, 16 (6):536-542. [Details]
Ryan S, McNicholas W.; (2010) 'The effect of continuous positive airway pressure on C-reactive protein levels in patients with obstructive sleep apnea syndrome'. Chest, 137 (2):496-497. [Details]
Ryan, S,Doherty, LS,Nolan, GM,McNicholas, WT; (2009) 'Effects of Heated Humidification and Topical Steroids on Compliance, Nasal Symptoms, and Quality of Life in Patients with Obstructive Sleep Apnea Syndrome Using Nasal Continuous Positive Airway Pressure'. Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 5 :422-427. [Details]
Ryan, S.,McNicholas, W. T.; (2009) 'Inflammatory cardiovascular risk markers in obstructive sleep apnoea syndrome'. Cardiovasc Hematol Agents Med Chem, 7 (1):76-81. Available Online [Details]
Ryan, S.,Taylor, C. T.,McNicholas, W. T.; (2009) 'Systemic inflammation: a key factor in the pathogenesis of cardiovascular complications in obstructive sleep apnoea syndrome?'. Thorax, 64 (7):631-6. Available Online [Details]
Ryan, S.,Doherty, L. S.,Rock, C.,Nolan, G. M.,McNicholas, W. T.; (2009) 'Effects of Salmeterol on Sleeping Oxygen Saturation in Chronic Obstructive Pulmonary Disease'. Respiration, . Available Online [Details]
Ryan, S.,McNicholas, W. T.; (2008) 'Intermittent hypoxia and activation of inflammatory molecular pathways in OSAS'. Arch Physiol Biochem, 114 (4):261-6. Available Online [Details]
McNicholas WT, Heneghan C, de Chazal P, Ryan S, Chua CP, Doherty L, Boyle P, Nolan P, ; (2008) 'Electrocardiogram recording as a screening tool for sleep disordered breathing'. Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 3 (NA):223-228. [Details]
Ryan, S,Ward, S,Heneghan, C,McNicholas, WT; (2007) 'Predictors of decreased spontaneous baroreflex sensitivity in obstructive sleep apnea syndrome'. Chest, 131 :1100-1107. [DOI] [Details]
Ryan S, Nolan GM, Hannigan E, Cunningham S, Taylor C, McNicholas WT. (2007) 'Cardiovascular risk markers in obstructive sleep apnoea syndrome and correlation with obesity'. Thorax, 62 (6):509-514. [Details]
Ryan, S, McNicholas, WT & Taylor, CT.; (2007) 'A critical role for p38 MAP kinase in NF-kB signaling during intermittent hypoxia / reoxygenation'. Biochemical and Biophysical Research Communications, 355 (3):728-733. [Details]
Ryan, S,Taylor, CT,McNicholas, WT; (2006) 'Predictors of elevated nuclear factor-kappa B-dependent genes in obstructive sleep apnea syndrome'. American Journal of Respiratory and Critical Care Medicine, 174 :824-830. [DOI] [Details]
McNicholas WT, Ryan S. (2006) 'Obstructive sleep apnoea syndrome: translating science to clinical practice'. Respirology (Carlton, Vic.), 11 (2):136-144. [Details]
Ward, S.,Ryan, S.,Mc Nicholas, W. T.,Heneghan, C.; (2006) 'Comparison of baroreflex sensitivity measures for assessing subjects with Obstructive Sleep Apnea'. Conf Proc IEEE Eng Med Biol Soc, 1 :3572-5. [Details]
Nolan GM, Ryan S, O¿Connor TM, McNicholas WT. (2006) 'Comparison of Three Auto- adjusting Positive Pressure Devices in Patients with Sleep Apnoea'. European Respiratory Journal, . [Details]
Ryan, S,Taylor, CT,McNicholas, WT; (2005) 'Selective activation of inflammatory pathways by intermittent hypoxia in obstructive sleep apnea syndrome'. Circulation, 112 :2660-2667. [DOI] [Details]

Other Journals

Ryan S, Kent BD, McNicholas WT. (2011) 'Genetics of Cardiovascular Consequences of Obstructive Sleep Apnoea Syndrome' Sleep Medicine Clinics . [Details]
Ryan S, Taylor CT, McNicholas WT. (2009) 'Systemic inflammation-a key factor in the pathogenesis of cardiovascular complications in obstructive sleep apnoea syndrome' Postgraduate Medical Journal . [Details]
Ryan S, McNicholas WT. (2006) 'Obstructive sleep apnoea syndrome' Medicine weekly . [Details]
Ryan S (2006) 'Predictors of elevated tumour necrosis factor alpha level in obstructive sleep apnoea syndrome' Eurpean Respiratory Review . [Details]
Ryan S, McNicholas WT. (2006) 'Sleep-related breathing disorders' Irish Medical News . [Details]
Ryan S, Siemon G, Drogemuller A, Rameken M, Vater M, Senges, Seidl K. (2001) 'Two year follow-up of 321 patients with an implantable Cardioverter/defibrillator: comparison of patients with and without atrial fibrillation' Z Kardiol . [Details]

Conference Publications

Ryan, S; Russell, A; Nolan, G; McNicholas, WT (2015) Clinical predictors of obesity hypoventilation syndrome in obese subjects with obstructive sleep apnea ERS International Congress Amsterdam, , 26-SEP-15 - 30-SEP-15 [Details]
                                         

Abstract

McCague, S,Kent, BD,Nolan, G,Hayes, L,Ryan, S,McNicholas, WT (2012) The Relationship of Alcohol Consumption to Disease Severity in a Sleep Apnoea Cohort. Abstract [Details]
Mc Cague, S,Kent, BD,Nolan, G,Ryan, S,Mc Nicholas, WT (2012) THE RELATIONSHIP OF ALCOHOL CONSUMPTION TO DISEASE SEVERITY IN A SLEEP APNOEA COHORT. Abstract [Details]
       

Reviews

Kent, BD,Ryan, S,McNicholas, WT (2011) Obstructive sleep apnea and inflammation: Relationship to cardiovascular co-morbidity. Reviews [DOI] [Details]
Ryan, S,Taylor, CT,McNicholas, WT (2009) Systemic inflammation: a key factor in the pathogenesis of cardiovascular complications in obstructive sleep apnoea syndrome?. Reviews [DOI] [Details]
McNicholas, WT,Ryan, S (2006) Obstructive sleep apnoea syndrome: Translating science to clinical practice. Reviews [Details]
                                                                                 

Research

Research Interests

  

Pathophysiology of cardiovascular diseases in obstructive sleep apnoea

 

Inflammatory responses to intermittent hypoxia

 

Effect of intermittent hypoxia on adipose tissue  
 
UCD Medicine Research Individual Investigator 

                                           

Research Projects

Sponsor : Health Research Board (HRB)
Title : Targeting Adipose Tissue Inflammation by Intermittent Hypoxia: Towards Personalized Medicine in Obstructive Sleep Apnoea
Start Date / End Date : 01-DEC-17 / 30-NOV-21
Sponsor : University College Dublin Foundation Ltd.
Title : UCD Foundation Research Fellow
Start Date / End Date : 05-NOV-15 / 31-OCT-17
Sponsor : Health Research Board (HRB)
Title : The role of adipose tissue in systemic inflammation in response to intermittent hypoxia and the importance of these events in the development of atherosclerosis.
Start Date / End Date : 01-DEC-11 / 30-MAY-16
Sponsor : University College Dublin (UCD)
Title : Signalling mchanisms of intermittent hypoxia-induced atherosclerosis
Start Date / End Date : 01-MAY-13 / 31-OCT-14

Recent Postgraduates

Dr Sophie Crinion (PhD - Co-supervisor)
 

Collaborators

Internal Collaborators

Internal

Prof Cormac Taylor, UCD

Prof Walter McNicholas, St. Vincent¿s University Hospital

Prof Helen Roche, UCD

Dr Eoin Cummins, UCD

Dr Fiona McGillicuddy, UCD

Prof Donal O¿Shea, St. Vincent¿s University Hospital

Prof Jonathan Dodd, St. Vincent¿s University Hospital

External Collaborators

External

Prof Jean-Louis Pepin/Prof Patrick Levy, University of Grenoble, France

Dr Renata Riha, University of Edinburgh, UK

Dr Murtaza Tambuwala, University of Ulster, UK

Dr Brian Kent, Guy¿s and St. Thomas¿ Hospital, London, UK

Prof Conor Heneghan, Fitbit Technologies, San Francisco, US

European Sleep Apnoea Database (ESADA) investigators