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Simon Coyle Rowan

Postdoc Research Fellow Lvl Ii

School Of Medicine
Conway Institute
Belfield
Dublin 4

Tel:
Email: simon.coylerowan@ucd.ie

Biography

Simon C Rowan (BSc, PhD) is a post doctoral research fellow in the respiratory research group of Professor Paul McLoughlin in the Conway Institute, UCD. 

His current research interests include investigating the role of the bone morphogenetic protein antagonist Gremlin1 in the pathogenesis of hypoxic pulmonary hypertension and the development of novel methods and techniques for the preservation of physiological lung function ex vivo.  

He has lectured in respiratory physiology and biomedical engineering in the UCD School of Medicine and contributes to lecture series on human and comparative physiology in the College of Health and Agriculture.

He has authored and contributed to scientific, peer reviewed publications, in the highest impact journals in his field such as the Lancet Respiratory Medicine and Circulation.  

His full publication list is available at: http://orcid.org/0000-0002-4103-4421 
 

Professional

Honours and Awards

Year: 2011.
Title: Ad Astra Scholarship
Year: 2010.
Title: Ad Astra Scholarship
Year: 2012.
Title: Future of Science Fund Scholarship
Year: 2009.
Title: Ad Astra Scholarship
             

Education

Year 2009 Institution: University College Dublin
Qualification: BSc Subject:
Year 2011 Institution: University College Dublin
Qualification: PhD Subject:
     

Journals Edited

American Journal Of Physiology - Lung Cellular And Molecular Physiology: Reviewer.
 

Publications

     

Peer Reviewed Journals

Murphy N, Gaynor KU;Rowan SC;Walsh SM;Fabre A;Boylan J;Keane MP;McLoughlin P (2016) 'Altered Expression of Bone Morphogenetic Protein Accessory Proteins in Murine and Human Pulmonary Fibrosis'. The American journal of pathology, 186 (3):600-15. [DOI] [Details]
Rowan, SC. Keane, MP. Gaine, S. McLoughlin, P. (2016) 'Hypoxic pulmonary hypertension in chronic lung diseases: novel vasoconstrictor pathway'. The Lancet. Respiratory medicine, 4 (3):225-36. [DOI] Link to full text [Details]
Rowan, S. C. McLoughlin, P (2014) 'Hypoxic pulmonary hypertension: the paradigm is changing'. Experimental Physiology, 99 (6):837-838. Available Online [DOI] Link to full text [Details]
Li L, Howell K;Sands M;Banahan M;Frohlich S;Rowan SC;Neary R;Ryan D;McLoughlin P (2013) 'The alpha and delta isoforms of CREB1 are required to maintain normal pulmonary vascular resistance'. PLoS ONE, 8 (12):e80637. [DOI] [Details]
Skelly JR, Rowan SC, Jones JF, O'Halloran KD (2013) 'Upper airway dilator muscle weakness following intermittent and sustained hypoxia in the rat: effects of a superoxide scavenger'. Physiological research / Academia Scientiarum Bohemoslovaca, 62 (2):187-196. [Details]
Cahill E, Rowan SC, Sands M, Banahan M, Ryan D, Howell K, McLoughlin P; (2012) 'The pathophysiological basis of chronic hypoxic pulmonary hypertension in the mouse: vasoconstrictor and structural mechanisms contribute equally'. Experimental Physiology, 97 (6):796-806. [DOI] [Details]
Cahill E, Costello CM, Rowan SC, Harkin S, Howell K, Leonard MO, Southwood M, Cummins EP, Fitzpatrick SF, Taylor CT, Morrell NW, Martin F, McLoughlin P; (2012) 'Gremlin plays a key role in the pathogenesis of pulmonary hypertension'. Circulation, 125 (7):920-930. Available Online [DOI] Link to full text [Details]
 

Conference Publications

Rowan, SC; Cornwell, J; Rochfort, K; McLoughlin, P (2016) An optimized viscosity solution can better preserve physiological lung function ex vivo during extended ventilation and perfusion prior to transplantation American Thoracic Society International Conference San Francisco, [Details]
Rowan SC, Cornwell J, McLoughlin P (2015) Gremlin1 a contributor to attenuated VEGF signaling in the hypoxic pulmonary hypertensive lung Keystone Symposia on Hypoxia: From Basic Mechanisms to Therapeutics, Dublin, 2015 [Details]
Rowan SC, Cornwall J, McLoughlin P (2015) Gremlin1 blocks VEGF signaling in the lung, a second pro-hypertensive action contributing to hypoxic pulmonary hypertension American Thoracic Society International Conference (2015), Denver, Am J Resp Crit care Med 191;2015:A1933 Available Online [Details]
Rowan SC, Cahill E, McLoughlin P (2013) The BMP antagonist gremlin contributes to pathological remodelling of the hypoxic pulmonary vasculature by reducing eNOS expression and activity American Thoracic Society International Conference (2013), Philidelphia, Am J Resp Crit Care Med 187; 2013:A2256 Available Online [Details]
Rowan SC, Cahill E, McLoughlin P (2013) Effects of gremlin haploinsufficiency on the pulmonary vascular endothelium in the hypoxic murine lung 37th Congress of IUPS (2013), Birmingham; Proc 37th IUPS, PCD080 Available Online [Details]
Coyle-Rowan, S. Cahill, E. Sands. M, Banahan. M, Ryan, D. Howell, K. McLoughlin, P (2012) Structural narrowing of the vascular lumen is the major mechanism underlying chronic hypoxic pulmonary hypertension in the mouse, not rho kinase dependent vasoconstriction American thoracic Society International Conference (2012), San Francisco, Am J Resp Crit Care Med 185;2012:A2628 Available Online [Details]
Rowan, SC. Cahill, E. McLoughlin, P. (2012) Haploinsufficiency of gremlin augments NOS expression and activity in the hypoxic pulmonary circulation Keystone Symposia on Pulmonary Vascular Disease and Right Ventricular Dysfunction: Current Concepts and Future Therapies, Montery, CA, 2012 [Details]
Rowan, S. C. Cahill, E. Howell, K. McLoughlin, P (2012) A modelling approach to assess the contribution of vascular remodelling to increased pulmonary vascular resistance in hypoxic pulmonary hypertension Physiological Society Main Meeting (2012), Edinburgh; Proc Physiol Soc 27, PC218 Available Online [Details]
Coyle-Rowan, S. Cahill, E. Costello, CM. Howell, K. Martin, F. McLoughlin, P. (2011) Hypoxic up regulation of the BMP antagonist gremlin1 contributes to the development of pulmonary hypertension American Thoracic Society International Conference (2011), Denver, Colorado; Am J Resp Crit Care Med 183;2011:A3396 Available Online [Details]
Coyle-Rowan S, Cahill E, Harkin S, Costello CM, Howell K, Martin F, McLoughlin P; (2010) Hypoxic upregulation of the BMP antagonist gremlin1 contributes to the development of pulmonary hypertension Physiological Society Main Meeting (2010), Birmingham; Proc Physiol Soc 20, PC06 Available Online [Details]
Coyle-Rowan S & O'Halloran KD; (2009) Intermittent hypoxia impairs rat upper airway muscle function: protective effects of a superoxide scavenger Physiological Society Main Meeting (2009), Dublin; Proc Physiol Soc 15: PC56 Available Online [Details]
                                                                                                                 

Research

Research Interests

My research, as part of the respiratory research group in the Conway Institute, is focused on the development of novel therapeutic strategies for treating pulmonary hypertension (PH), a common complication of many chronic lung diseases such as chronic obstructive lung disease (COPD). Chronic lung diseases are among the leading causes of death world wide. PH significantly increases the morbidity and mortality associated with these diseases and currently there is now cure available. 
 
We utilise novel genetically modified animal models and advanced cell culture techniques to examine the contribution of the bone morphogenetic protein antagonist Gremlin1 to the pathogenesis of this debilitating disease. 


As part of our work combating chronic lung disease we are also involved in developing novel strategies to preserve lung function outside the body (ex vivo). Lung transplantation is the final therapeutic option for many suffering from a chronic lung disease. Many patients die awaiting a donor lung due to a world wide shortage of suitable organs and the short duration that a lung can be preserved ex vivo. We are actively investigating novel methods and techniques to help preserve physiological lung function ex vivo thereby helping to improve the available pool of donor organs for those in dire need of lung transplantation. 

Research Projects

Sponsor : Enterprise Ireland (EI)
Title : UCD Technologies: Modified viscosity solution for ex vivo lung preservation
Start Date / End Date : 20-JAN-15 / 20-APR-15
   

Collaborators

Internal Collaborators

Dr Malachy O'Rourke, School of Mechanical and Materials Engineering, UCD

External Collaborators

Dr Keith Rochfort, School of Biotechnology, DCU 

Dr Phil Cummins, School of Biotechnology, DCU