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Tom Flanagan

Lecturer/Assistant Professor

School Of Medicine
Health Sciences Centre
Belfield
Dublin 4

Tel: +353 1 7166631
Email: thomas.flanagan@ucd.ie

Biography

Dr. Flanagan is a graduate of Anatomy from NUI, Galway (2000) and was awarded a Ph.D. (Anatomy) in 2005. He subsequently took up a post-doctoral position at the Cardiovascular Tissue Engineering Laboratory, Helmholtz Institute for Biomedical Engineering at Aachen University in Germany, where he co-ordinated a project to develop autologous heart valve prostheses for surgical implantation. Dr. Flanagan joined the UCD School of Medicine in 2008 as Lecturer in Human Anatomy, and heads the Tissue Engineering Research Group at the School.

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Professional

Honours and Awards

Year: 2016.
Title: UCD Medicine Teacher of the Year Award (Pre-Clinical) 2016
Year: 2015.
Title: UCD Medicine Teacher of the Year Award (Pre-Clinical) 2015
Year: 2016.
Title: UCD-Penang Medical College (PMC) Medicine Class of 2019 - Favourite Teacher Award
Year: 2015.
Title: UCD-Penang Medical College (PMC) Medicine Class of 2018 - Favourite Teacher Award
Year: 2015.
Title: UCD-Penang Medical College (PMC) Medicine Class of 2017 - Favourite Teacher Award
Year: 2014.
Title: UCD-Penang Medical College (PMC) Medicine Class of 2016 - Favourite Teacher Award
Year: 2002.
Title: DAAD Visiting Research Fellowship (Germany)

Associations

Association: Matrix Biology Ireland (MBI), Function/Role: Secretary (2015-present), Council Member (2013-present)
Association: Microscopy Society of Ireland (MSI), Function/Role: Honorary Secretary (2008-2012), Committee Member (2008-present)
Association: Tissue Engineering & Regenerative Medicine International Society (TERMIS), Function/Role: Member (2004-present)
Association: Anatomical Society, Function/Role: Member (2013-present)
     

Conference Contributions

Flanagan TC, Jockenhoevel S (2015) The Hype & Hope of Cardiovascular Tissue Engineering Strategies. [Invited Oral Presentation], Tissue Engineering & Regenerative Medicine International Society (TERMIS) World Congress, Boston, MA, USA , 08-SEP-15 - 11-SEP-15.
Strauther S, Clarke F, Flanagan TC (2013) Cardiovascular Tissue Engineering: Elastin-Synthesizing Potential of Neonatal versus Adult Arterial Smooth Muscle Cells. [Oral Presentation], Tissue Engineering & Regenerative Medicine International Society (TERMIS)-Asia-Pacific Chapter Meeting, Shanghai and Wuzhen, China , 23-OCT-13 - 26-OCT-13.
Flanagan TC (2012) Tissue Engineering: Renewed Hope for Children with Broken Hearts?. [Invited Lecture], NCRC Seminar Series, National Children's Research Centre, Dublin , 09-OCT-12 - 09-OCT-12.
Flanagan, TC; (2011) Rebuilding Broken Hearts: Tapping into the Future, or Just a Pipe Dream?. [Invited Lecture], EBRC Seminar Series 2011, Roslin Institute, Edinburgh, Scotland , 22-JUN-11 - 22-JUN-11.
Flanagan TC, Breuer C, Korossis S; (2010) Cardiovascular Tissue Engineering: From Bench to Bedside. [Chaired Session], Tissue Engineering & Regenerative Medicine International Society (TERMIS)-EU Chapter Meeting, Galway, Ireland , 14-JUN-10 - 17-JUN-10.
Flanagan TC, Lueders C, Jockenhoevel S; (2009) Cardiovascular tissue engineering. [Oral Presentation], Marie Curie Cutting Edge Practical Training Course: Tissue Engineering, Stem Cells & Biocompatibility Testing of Materials, Aachen, Germany , 24-AUG-09 - 03-SEP-09.
Flanagan TC; (2009) Stem cells & tissue engineering therapy for cardiovascular disease. [Invited Lecture], International Summer School on Stem Cells & Regenerative Medicine, Piran, Slovenia , 21-AUG-09 - 29-AUG-09.
Flanagan TC, Koch S, Sachweh, JS, Tschoeke B, Tanios F, Schnoering H, Tolba RH, Schmitz-Rode T, Jockenhoevel S; (2009) Functional autologous tissue-engineered vascular grafts in the systemic circulation: a microscopic analysis. [Oral Presentation], 33rd Annual Symposium of the Microscopical Society of Ireland, University College Dublin , 26-AUG-09 - 28-AUG-09.
Flanagan TC; (2009) Opening Session Chair. [Chaired Session], 33rd Annual Symposium of the Microscopical Society of Ireland, University College Dublin , 26-AUG-09 - 28-AUG-09.
Flanagan TC, Frese J, Koch S, Sachweh JS, Bernstein N, Schmitz-Rode T, Jockenhoevel S; (2008) In vivo evaluation of fibrin-based tissue-engineered heart valves in a sheep model. [Oral Presentation], Tissue Engineering & Regenerative Medicine International Society (TERMIS)-EU Chapter Meeting, Porto, Portugal , 22-JUN-08 - 26-JUN-08.
Flanagan TC, Cornelissen C, Koch S, Tschoeke B, Sachweh JS, Schmitz-Rode T, Jockenhoevel S; (2007) Optimised dynamic conditioning enhances in vitro development of autologous fibrin-based tissue engineered heart valves. [Oral Presentation], Tissue Engineering & Regenerative Medicine International Society (TERMIS)-EU Chapter Meeting, London, England , 04-SEP-07 - 07-SEP-07.
Tschoeke B, Flanagan TC, Sriharwoko M, Deichmann T, Ellä V, Koch S, Glitz A, Schmitz-Rode T, Gries T, Kellomäki M, Jockenhoevel S; (2007) Tissue-engineering of small calibre vascular grafts. [Oral Presentation], Tissue Engineering & Regenerative Medicine Society International (TERMIS)-EU Chapter Meeting, London, England , 04-SEP-07 - 07-SEP-07.
Veggian P, Sachweh JS, Koch S, Tschoeke B, Flanagan TC, Schmitz-Rode T, Jockenhoevel S; (2007) Ex vivo expansion of pericardial patch structures. [Poster Presentation], Biomedica Life Science Summit, Aachen, Germany , 21-MAR-07 - 22-MAR-07.
Cornelissen C, Flanagan TC, Schmitz-Rode T, Jockenhoevel S; (2007) Optimised dynamic conditioning enhances in vitro development of autologous fibrin-based tissue engineered heart valves. [Poster Presentation], Biomedica Life Science Summit, Aachen, Germany , 21-MAR-07 - 22-MAR-07.
Flanagan TC, Wilkins B, Black A, Jockenhoevel S, Smith TJ, Pandit AS; (2003) Reconstituted heart valve tissue using a collagen/chondroitin sulphate matrix. [Oral Presentation], 2nd Conference of the UK Society for Biomaterials, Belfast, N. Ireland , 23-JUN-03 - 25-JUN-03.
Flanagan TC, Mulvihill A, Wilkins B, Black A, Jockenhoevel S, Pandit A; (2003) Characterisation of mitral valve interstitial cells and endocardial cells in 2-D- and 3-D-culture. [Oral Presentation], 30th Annual Congress of the European Society for Artificial Organs, Aachen, Germany , 03-SEP-03 - 06-SEP-03.
Flanagan TC, Mulvihill A, Black A, Jockenhoevel S, Wilkins B; (2002) Effects of glycosaminoglycan addition to a collagen-based tissue model derived from porcine mitral valve. [Poster Presentation], 1st Berlin Symposium on Tissue Engineering of Cardiovascular Structures, Berlin, Germany , 09-NOV-02 - 10-NOV-02.
Jockenhoevel S, Fuchs H, Roehl A, Dresbach H, Strehlau E, Smajic S, Schilling L, Flanagan T, Berndt E, Gries T, Messmer BJ, Autschbach R; (2002) Cardiovascular tissue engineering and bioreactor technologies. [Poster Presentation], st International Meeting of the Stem Cell Network North Rhine Westphalia, Duesseldorf, Germany , 27-NOV-02 - 28-NOV-02.
Flanagan TC, Mulvihill A, Black A, Wilkins B; (2002) In vitro construction of viable, functional tissue derived from mammalian heart valve using a natural extracellular matrix scaffold. [Oral Presentation], 26th Annual Symposium of the Microscopical Society of Ireland, Galway, Ireland , 28-AUG-02 - 30-AUG-02.
Flanagan T, Wilkins B; (2001) Immunohistochemical characterisation of porcine mitral valve interstitial cells in culture. [Oral Presentation], 25th Annual Symposium of the Microscopical Society of Ireland, Belfast, N. Ireland , 28-AUG-01 - 30-AUG-01.

Committees

Committee : Matrix Biology Ireland
Committee : Microscopy Society of Ireland
Committee : UCD School of Medicine - Research, Innovation & Impact Group (RIIG)
Committee : UCD School of Medicine - Medicine Degrees Committee I
Committee : UCD School of Medicine - BHLS Degree Committee
Committee : UCD School of Medicine - Admissions Committee
Committee : UCD School of Medicine - Staff-Student Committee

Employment

Employer: Helmholtz Institute for Biomedical Engineering, Aachen University
Position: Post-Doctoral Research Associate

Education

Year 2000 Institution: National University of Ireland, Galway
Qualification: BSc (First Class Hons) Subject: Anatomy
Year 2005 Institution: National University of Ireland, Galway
Qualification: PhD Subject: Anatomy

Languages

German:
   

Journals Edited

Journal Of Biomedical Materials Research Part A: Reviewer.
Artificial Organs : Reviewer.
Biomaterials: Reviewer.
Cells Tissues Organs: Reviewer.
Tissue Engineering, Part A: Reviewer.
Journal Of The Mechanical Behavior Of Biomedical Materials: Reviewer.
Circulation: Reviewer.
Annals Of Biomedical Engineering: Reviewer.
Acta Biomaterialia: Reviewer.
Plos One: Reviewer.
 

Publications

 

Book Chapters

Jockenhoevel S, Flanagan TC (2011) 'Cardiovascular tissue engineering based on fibrin gel scaffolds' In: Eberle D (eds). Tissue Engineering for Tissue and Organ Regeneration. Rijeka, Croatia: Intech. , pp.35-48 [Details]
Flanagan TC, Olszewski S, Frese J, Jockenhoevel S; (2010) 'Hybrid biomaterials for engineering vascular tissues' In: Jabbari E, Khademhosseini A (eds). Biologically-Responsive Hybrid Biomaterials. Singapore: World Scientific Publishing Co. , pp.373-387 [Details]
Black A, Corcoran BM, Heying R, Jockenhoevel S, Flanagan TC; (2010) 'The mitral valve: development, structure, pathology and tissue engineering' In: Schmitt, L.; Konig, T (eds). Advances in Cardiovascular Research. New York, USA: Nova Publishers. , pp.1-45 [Details]
Jockenhoevel S, Flanagan TC, Wilhelmi M; (2009) 'Tissue engineering - innovative strategies towards living implants' In: Jacobs M, Branchereau A (eds). Innovative Cardiovascular Procedures. Turin, Italy: Edizioni Minerva Medica. , pp.49-55 [Details]
 

Peer Reviewed Journals

Brougham CM, Levingstone TJ, Shen N, Cooney GM, Jockenhoevel S, Flanagan TC, O'Brien FJ (2017) 'Freeze-drying as a novel biofabrication method for achieving a controlled microarchitecture within large, complex natural biomaterial scaffolds'. Advanced healthcare materials, in press . [DOI] [Details]
Brougham CM, Levingstone TJ, Jockenhoevel S, Flanagan TC, O'Brien FJ (2015) 'Incorporation of fibrin into a collagen-glycosaminoglycan matrix results in a scaffold with improved mechanical properties and enhanced capacity to resist cell-mediated contraction'. Acta Biomaterialia, 26 :205-214. [Details]
Liu MM, Flanagan TC, Lu CC, French AT, Argyle DA, Corcoran BM (2015) 'Culture and characterisation of canine mitral valve interstitial and endothelial cells'. Veterinary Journal, 204 (1):32-39. [Details]
Woods I, Flanagan TC (2014) 'Electrospinning of biomimetic scaffolds for tissue-engineered vascular grafts: threading the path'. Expert Review of Cardiovascular Therapy, 12 (7):815-832. [Details]
Weinandy S, Babczyk P, Dreier A, Unger RE, Flanagan TC, Kirkpatrick CJ, Zenke M, Klee D, Jockenhoevel S (2014) 'Ovine carotid artery-derived cells as an optimized supportive cell layer in 2-D capillary network assays'. PLoS ONE, 9 (3):e91664. [Details]
Weinandy S, Laffar S, Dreier A, Unger R, Kirkpatrick CJ, Losel R, Flanagan TC, van Zandvoort M, Hermanns-Sachweh B, Klee D, Jockenhoevel S (2014) 'Biofunctionalised microfibre-assisted formation of intrinsic three-dimensional capillary-like structures'. Tissue Engineering Part A, 20 (13-14):1858-1869. [Details]
Tuemen M, Nguyen DVA, Raffius J, Flanagan TC, Dietrich M, Frese J, Schmitz-Rode T, Jockenhoevel S (2013) 'Non-destructive analysis of extracellular matrix development in cardiovascular tissue-engineered constructs'. Annals of Biomedical Engineering, 41 :883-893. [Details]
Koch S, Stappenbeck N, Cornelissen CG, Flanagan TC, Mela P, Sachweh JS, Hermanns-Sachweh B, Jockenhoevel S (2012) 'Tissue engineering - selecting the optimal fixative for immunohistochemistry'. Tissue Engineering Part C: Methods, 18 :976-983. Available Online [Details]
Weinandy S, Rongen L, Schreiber F, Cornelissen C, Flanagan TC, Mahnken AH, Gries T, Schmitz-Rode T, Jockenhoevel S (2012) 'The BioStent - novel concept for a viable stent structure'. Tissue Engineering Part A, 18 :1818-1826. Available Online [Details]
Wirz S, Dietrich M, Flanagan TC, Bokermann G, Wagner W, Schmitz-Rode T, Jockenhoevel S; (2011) 'Influence of platelet-derived growth factor-AB on tissue development in autologous platelet-rich plasma gels'. Tissue Engineering, Part A, 17 (13-14):1891-1899. Available Online [Details]
Koch S, Flanagan TC, Sachweh JS, Tanios F, Schnoering H, Deichmann T, Ella V, Kellomaki M, Gronloh N, Gries T, Tolba RH, Schmitz-Rode T, Jockenhoevel S; (2010) 'Fibrin-polylactide-based tissue-engineered vascular graft in the arterial circulation'. Biomaterials, 31 (17):4731-4739. Available Online [Details]
Cholewinski E, Dietrich M, Flanagan TC, Schmitz-Rode T, Jockenhoevel S; (2009) 'Tranexamic acid - an alternative to aprotinin in fibrin-based cardiovascular tissue engineering'. Tissue Engineering, Part A, 15 (11):3645-3653. Available Online [Details]
Flanagan TC, Tschoeke B, Koch S, Sri Harwoko M, Deichmann T, Ella V, Sachweh JS, Kellomaki M, Gries T, Schmitz-Rode T, Jockenhoevel S; (2009) 'Tissue-engineered small-calibre vascular graft based on a novel biodegradable composite fibrin-polylactide scaffold'. Tissue Engineering, Part A, 15 (8):1909-1918. Available Online [Details]
Flanagan TC, Tschoeke B, Diamantouros S, Schmitz-Rode T, Jockenhoevel S; (2009) 'Mechanical properties of tissue-engineered vascular grafts: response to letter to the editor'. Artificial Organs, 33 (2):194-196. Available Online [Details]
Flanagan TC, Sachweh JS, Frese J, Schnoering H, Gronloh N, Koch S, Tolba RH, Schmitz-Rode T, Jockenhoevel S; (2009) 'In vivo remodeling and structural characterization of fibrin-based tissue-engineered heart valves in the adult sheep model'. Tissue Engineering, Part A, 15 (10):2965-2976. Available Online [Details]
Tschoeke B, Flanagan TC, Cornelissen A, Koch S, Roehl A, Sri Harwoko M, Sachweh JS, Gries T, Schmitz-Rode T, Jockenhoevel S; (2008) 'Development of a composite degradable/nondegradable tissue-engineered vascular graft'. Artificial Organs, 32 (10):800-809. Available Online [Details]
Binnebosel M, Rosch R, Junge K, Flanagan TC, Schwab R, Schumpelick V, Klinge U; (2007) 'Biomechanical analysis of overlap and mesh dislocation in an incisional hernia model in vitro'. Surgery, 142 (3):365-371. Available Online [Details]
Flanagan TC, Cornelissen C, Koch S, Tschoeke B, Sachweh JS, Schmitz-Rode T, Jockenhoevel S; (2007) 'The in vitro development of autologous fibrin-based tissue-engineered heart valves through optimised dynamic conditioning'. Biomaterials, 28 (23):3388-3397. Available Online [Details]
Flanagan TC, Black A, O'Brien M, Smith TJ, Pandit AS; (2006) 'Reference models for mitral valve tissue engineering based on valve cell phenotype and extracellular matrix analysis'. Cells Tissues Organs, 183 (1):12-23. Available Online [Details]
Flanagan TC, Wilkins B, Black A, Jockenhoevel S, Smith TJ, Pandit AS; (2006) 'A collagen-glycosaminoglycan co-culture model for heart valve tissue engineering applications'. Biomaterials, 27 (10):2233-2246. Available Online [Details]
Flanagan TC, Pandit A; (2003) 'Living artificial heart valve alternatives: a review'. European Cells and Materials, 6 :28-45. Available Online [Details]

Other Journals

Jockenhoevel S, Flanagan TC; (2008) 'Tissue-engineered heart valves: an alternative for the pediatric population' Congenital Cardiology Today 6 (12) :1-8. Available Online [Details]

Conference Publications

Flanagan TC, Frese J, Koch S, Sachweh JS, Bernstein N, Schmitz-Rode T, Jockenhoevel S; (2008) In vivo evaluation of fibrin-based tissue-engineered heart valves in a sheep model Tissue Engineering & Regenerative Medicine International Society (TERMIS)-EU Chapter Meeting [Details]
Flanagan TC, Frese J, Sachweh JS, Diamantouros S, Koch S, Schmitz-Rode T, Jockenhoevel S; (2008) The use of fibrin as an autologous scaffold material for cardiovascular tissue engineering applications: from in vitro to in vivo evaluation 4th European Congress for Medical & Biomedical Engineering Antwerp, Belgium, , 23-NOV-08 - 27-NOV-08 [Details]
Diamantouros SE, Flanagan TC, Finocchiaro T, Schmitz-Rode T, Jockenhoevel S; (2008) Design and construction of a system for the application of variable pressure to tissue-engineered blood vessels 4th European Congress for Medical & Biomedical Engineering Antwerp, Belgium, , 23-NOV-08 - 27-NOV-08 [Details]
Tschoeke B, Flanagan TC, Sriharwoko M, Deichmann T, Ellä V, Koch S, Glitz A, Schmitz-Rode T, Gries T, Kellomäki M, Jockenhoevel S; (2007) Tissue-engineering of small calibre vascular grafts Tissue Engineering & Regenerative Medicine International Society (TERMIS)-EU Chapter Meeting [Details]
Flanagan TC, Cornelissen C, Koch S, Tschoeke B, Sachweh JS, Schmitz-Rode T, Jockenhoevel S; (2007) Optimised dynamic conditioning enhances in vitro development of autologous fibrin-based tissue engineered heart valves Tissue Engineering & Regenerative Medicine International Society (TERMIS)-EU Chapter Meeting [Details]
Diamantouros S, Flanagan TC, Sachweh JS, Schmitz-Rode T, Jockenhoevel S; (2007) Vasoactive drugs reduce smooth muscle cell-mediated cell contraction of fibrin gel in culture: implications for fibrin based heart valve tissue engineering Tissue Engineering & Regenerative Medicine International Society (TERMIS)-EU Chapter Meeting [Details]
Veggian P, Sachweh JS, Flanagan TC, Koch S, Tschoeke B, Schmitz-Rode T, Jockenhoevel S; (2007) Ex vivo expansion of pericardial patch structures Tissue Engineering and Regenerative Medicine International Society (TERMIS)-EU Chapter Meeting [Details]
Flanagan TC, Mulvihill A, Wilkins B, Black A, Jockenhoevel S, Pandit A; (2003) Characterisation of mitral valve interstitial cells and endocardial cells in 2-D- and 3-D-culture 30th Annual Congress of the European Society for Artificial Organs [Details]
Flanagan T, Wilkins B, Black A, Jockenhoevel S, Pandit A; (2003) Reconstituted heart valve tissue using a collagen/chondroitin sulphate matrix 2nd Conference of the UK Society for Biomaterials [Details]
Flanagan TC, Mulvihill A, Black A, Wilkins B; (2002) In vitro construction of viable, functional tissue derived from mammalian heart valve using a natural extracellular matrix scaffold 26th Annual Symposium of the Microscopical Society of Ireland [Details]
Flanagan T, Wilkins B; (2001) Immunohistochemical characterisation of porcine mitral valve interstitial cells in culture 25th Annual Symposium of the Microscopical Society of Ireland [Details]
                                       

Presented Papers

Kreitz S, Dohmen G, Diamantouros S, Frese J, Flanagan TC, Schmitz-Rode T, Autschbach R, Jockenhoevel S ; (2009) Novel dynamic bioreactor system for heart valve cultivation under echocardiographic control. IFMBE Proceedings Volume 25: Presented Papers [Details]
Diamantouros SE, Flanagan TC, Finocchiaro T, Deichmann T, Wilhelmi M, Schmitz-Rode T, Jockenhoevel S ; (2009) Development of a system for the performance and evaluation of mechanical conditioning on tissue-engineered vascular grafts. IFMBE Proceedings Volume 25: Presented Papers [Details]
Flanagan TC, Frese J, Sachweh JS, Diamantouros S, Koch S, Schmitz-Rode T, Jockenhoevel S ; (2008) The use of fibrin as an autologous scaffold material for cardiovascular tissue engineering applications: from in vitro to in vivo evaluation. IFMBE Proceedings Volume 22: Presented Papers [Details]
Diamantouros S, Flanagan TC, Finocchiaro T, Schmitz-Rode T, Jockenhoevel S ; (2008) Design and construction of a system for the application of variable pressure to tissue-engineered blood vessels. IFMBE Proceedings Volume 22: Presented Papers [Details]
                                                                                             

Research

Research Interests

TE UCD logo

- Cardiovascular disease, congenital heart defects
- Cardiovascular tissue engineering
- In vitro models of disease (myxomatous mitral valve disease, breast cancer)
- Valvular and vascular cell populations / mesenchymal stem cells
- Biological scaffold technologies / electrospinning / 3-D bio-printing
- Bioreactor design & development

Dr. Flanagan's research interests lie in the fields of cardiovascular disease and tissue engineering, and in particular the development of novel heart valve prostheses. Heart valve disease has a devastating effect worldwide, and current treatment options, while enhancing the quality of life of a patient, are not ideal. Mechanical heart valves are associated with long-term anti-coagulation therapy, as well as infection, structural failure and emboli, while biological prostheses are prone to calcification in juveniles and tissue deterioration. Tissue engineering has emerged as a potential approach to combat these inadequacies, by developing living replacements which are constructed using cells and materials derived from the patient, removing the potential for graft rejection. Dr. Flanagan's research has spanned from the characterisation of heart valve cell populations for identifying potential cell sources for tissue-engineered valves, to scaffold development (collagen-glycosaminoglycan composite, fibrin) for valve construction, through to the in vivo application of autologous valves in an adult sheep model. The latter study was performed at the laboratory of Dr. Stefan Jockenhoevel, Helmholtz Institute for Biomedical Engineering, Aachen University in Germany, using a fibrin scaffold and customised bioreactor conditioning technique.

Dr. Flanagan's current research focus is on the development of novel, autologous elastogenic vascular grafts for the repair of congenital heart defects - a project funded by the National Children's Research Centre (NCRC)/Children's Medical & Research Foundation (CMRF). Congenital cardiovascular defects are present in about 1% of all live births. Children born with a single pumping chamber, for example, are considered a mortality risk. The treatment of choice for such defects is staged surgical reconstruction, with the final stage involving connection of the inferior vena cava to the pulmonary artery with a vascular graft conduit. A significant limitation in this field is the inability of current graft materials to grow and remodel as the patient grows. Tissue engineering has emerged as an exciting alternative for the production of living vascular conduits with the potential for growth and remodelling within the patient. A significant limitation with current tissue-engineered conduits is stretching of the wall after implantation with a consequent risk of graft rupture. It is thought that the absence of elastic fibres, which protect vessels against over-expansion, may ultimately be responsible for this expansion. This study aims to produce a novel vascular conduit that can be constructed entirely from materials isolated from the infant, removing the potential for graft rejection, and providing the patient with a living, elastic conduit amenable to growth. A tubular scaffold material will be designed and tailored specifically to encourage formation of elastic walls by living cells, while biochemical supplementation and mechanical conditioning will be optimised to promote the development of mechanically stable tissue. It is anticipated that the results of this study will form a substantial basis for the clinical application of patient-grown tissue-engineered vascular conduits in the repair of congenital cardiovascular defects.    

Research Projects

Sponsor : University College Dublin (UCD)
Title : Minimally-Invasive Devices using Advanced Scaffold Technology for Correction of Congenital & Acquired Cardiovascular Defects: Proof of Concept
Start Date / End Date : 01-APR-17 / 30-SEP-18
Sponsor : Irish Research Council (IRC)
Title : Development of an In-Vitro Urethral Model for Urinary Catheter Performance Evaluation
Start Date / End Date : 04-JAN-16 / 03-JAN-20
Sponsor : The Wellcome Trust (WT)
Title : Tissue-Engineered Vascular Grafts: A Novel Fabrication Technique to Improve Cellularisation of Tubular Electrospun Scaffolds
Start Date / End Date : 02-JUN-15 / 27-JUL-15
Sponsor : University College Dublin (UCD)
Title : Patient-Specific `Tumour Engineering¿: A Novel Test System To Help Predict Responses to Cancer Therapies: Proof-of-Concept
Start Date / End Date : 01-APR-15 / 30-SEP-16
Sponsor : Irish Heart Foundation
Title : Tissue Engineering of Functional Heart Valve Prostheses Based on a Natural Biodegradable Multicomponent Scaffold: Proof-of-Concept
Start Date / End Date : 01-JAN-14 / 31-DEC-14
Sponsor : University College Dublin (UCD)
Title : Neonatal vs Adult Arterial Smooth Muscle Cells: Identifying a Suitable Cell Source for Tissue-Engineered Vascular Grafts
Start Date / End Date : 01-MAY-13 / 31-OCT-14
Sponsor : University College Dublin (UCD)
Title : Tissue-Engineered Human Urethra as a Reconstruction Graft & In Vitro Catheterisation Test System: Proof-of-Concept
Start Date / End Date : 01-MAY-13 / 31-OCT-14
Sponsor : National Children's Research Centre, Our Lady's Children's Hospital, Crumlin (CRC)
Title : Autologous, elastogenic tissue-engineered vascular conduits for repair of congenital heart defects
Start Date / End Date : 01-OCT-12 / 01-OCT-16
Sponsor : University College Dublin (UCD)
Title : A Freeze-Dried Fibrin Scaffold for Cardiovascular Tissue Engineering Applications
Start Date / End Date : 03-AUG-09 / 31-JAN-11

Recent Postgraduates

Ian Woods, Doctor of Philosophy (PhD) - Thesis Supervisor
Caoimhe Keoghegan, Master of Science (MSc) -   Thesis Supervisor
Luke Glacken, Master of Science (MSc)   -   Thesis Supervisor
Sean Strauther, Master of Science (MSc)   -   Thesis Supervisor
Fionn Clarke, Master of Science (MSc)   -   Thesis Supervisor

Current Postgraduate Students

Owen Humphreys, Doctor of Philosophy (PhD)   -   Thesis Supervisor

Teaching

 

Modules Coordinated

201700   ANAT20090     Human Anatomy: Med. Sciences for Biomed.Engin
201700   ANAT20040     Human Anatomy: Neurosciences

Enhancement of Teaching

AXON: A Novel Interactive Educational Tool for Improved 3-D Understanding of Neuroanatomy: In the summer of 2012, we developed a freely-available interactive animated learning resource that could be used to improve spatial and functional understanding of neuroanatomical concepts. Original images were created in Adobe Illustrator, and subsequently animated using Motion software to illustrate sensory pathways. These animations were then integrated into a website using Adobe Fireworks and Dreamweaver to allow for an interactive user experience. The resulting pilot interactive website (AXON - Animated Exploration of Neuroanatomy) allows users to "stimulate" sensations in a virtual character at specified locations (foot, hand and face). Interactive images, animations, anatomical/clinical information, in addition to voice-over material, are provided in the package to assist the overall learning experience. The package has been integrated into the undergraduate Medicine curriculum to assist neuroanatomy teaching. A student survey has demonstrated that this tool can enhance the overall learning experience of neuroanatomy. The product will be further developed to aid teaching and learning of additional neuroanatomy topics. AXON is freely available for use at the following website: http://www.ucd.ie/mededtec/axon/Index.html Samples of the content are also available on YouTube: https://www.youtube.com/watch?v=oas7yemSG5g Chan C, Tattersall A, Flanagan TC (2012) Conquering neurophobia: interactive animation for neuroanatomy teaching. Ir J Med Sci, 181 Suppl II: S453.
     

Collaborators

Internal Collaborators

Dr. Eoin O'Cearbhaill, School of Mechanical & Materials Engineering
 
Dr. Amanda McCann, Conway Institute

Prof. James Jones, School of Medicine
 

External Collaborators

Prof. Stefan Jockenhoevel, Helmholtz Institute for Biomedical Engineering & Institute for Textile Technology, RWTH Aachen University, Germany

Alex Black, Department of Anatomy, National University of Ireland, Galway

Prof. Fergal O'Brien, Department of Anatomy (Royal College of Surgeons in Ireland) & Trinity Centre for Biomedical Engineering (Trinity College Dublin), Dublin

Prof. Brendan Corcoran, Royal (Dick) School of Veterinary Studies & Roslin Institute, University of Edinburgh, Scotland, UK