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Researchers at UCD

Timothy Lynch

Adjunct Professor

School Of Medicine
Health Sciences Centre
Belfield
Dublin 4

Tel:
Email: timothy.lynch@ucd.ie

Biography

Professor Tim Lynch is a Consultant Neurologist at the Mater Misericordiae University Hospital (MMUH) and Beaumont Hospital. He is also Director of the Dublin Neurological Institute at the MMUH and Professor of Neurology at University College Dublin (UCD) and Clinical Investigator at the Conway Institute, UCD. Prof Lynch is a Royal College of Surgeons medical graduate from 1984 and a UCD BSc Pharmacology graduate from 1986. He trained in clinical medicine initially in the Richmond Hospital and subsequently Beaumont Hospital, the Mater Misericordiae University Hospital before doing one year of paediatric neurology in Our Lady's Hospital for Sick Children, Crumlin. In 1990 Prof Lynch moved to New York and spent eight years at Columbia Presbyterian Medical Centre/Columbia University initially doing a residency in neurology under the supervision of Prof Lewis P Rowland before spending a two-year Fellowship in Movement Disorders & Genetics of Neurodegeneration under the supervision of Prof Stanley Fahn. During his Fellowship Prof Lynch developed an interest in Genetics of Movement Disorders and Neurodegeneration doing early linkage analysis and gene cloning. Prof Lynch returned to take up the post as Consultant Neurologist at the MMUH in 1998. He studied an Irish-American family with frontotemporal dementia, Parkinsonism and Amyotrophy. Prof Lynch and Wilhelmsen published seminal papers on Frontotemporal Dementia Syndrome linked to chromosome 17. Prof Lynch then helped to form collaboration with the Mayo Clinic, Washington University, St Louis and Maastricht University resulting in cloning the tau gene for Frontotemporal Dementia linked to chromosome 17 in a number of pedigrees. This paper was published in Nature in 1998. He has developed the Department of Neurology at the MMUH setting up a Movement Disorder Clinic, a Multiple Sclerosis Clinic, a Migraine and Headache Clinic, a Deep Brain Stimulation Clinic, a Stroke Unit culminating in the opening of the Dublin Neurological Institute at the MMUH in September 2008. He was appointed Professor of Neurology, University College Dublin in 2007 and Director of the Dublin Neurological Institute in 2008. Prof Lynch has published over eighty articles in peer-reviewed journals on the genetics of Parkinson¿s disease, neurodegeneration and other movement disorders. He collaborates with research groups at the Mayo Clinic, US, University College London, National Institute of Health, US and Conway Institute, University College Dublin. His main research interest includes Parkinson's disease, movement disorders, genetics of Parkinson¿s disease and Parkinsonism, genetics of atypical dementia and the genetics of multiple sclerosis.

Publications

     

Peer Reviewed Journals

Olszewska DA, Lynch T (2016) 'Is PARK10 a Locus for Familial PD? Yes or Not?'. Movement disorders : official journal of the Movement Disorder Society, . [DOI] [Details]
Murphy TM, Sullivan L, Lane C, O'Connor L, Barrett C, Hollywood D, Lynch T, Lawler M, Perry AS; (2011) 'In silico analysis and DHPLC screening strategy identifies novel apoptotic gene targets of aberrant promoter hypermethylation in prostate cancer'. Prostate, 71 (1):1-17. [DOI] [Details]
Ogaki K, Koga S;Heckman MG;Fiesel FC;Ando M;Labb¿¿ C;Lorenzo-Betancor O;Moussaud-Lamodi¿¿re EL;Soto-Ortolaza AI;Walton RL;Strongosky AJ;Uitti RJ;McCarthy A;Lynch T;Siuda J;Opala G;Rudzinska M;Krygowska-Wajs A;Barcikowska M;Czyzewski K;Puschmann A;Nishioka K;Funayama M;Hattori N;Parisi JE;Petersen RC;Graff-Radford NR;Boeve BF;Springer W;Wszolek ZK;Dickson DW;Ross OA (2015) 'Mitochondrial targeting sequence variants of the CHCHD2 gene are a risk for Lewy body disorders'. Neurology, 85 (23):2016-2025. [DOI] [Details]
Butler JS, Beiser IM;Williams L;McGovern E;Molloy F;Lynch T;Healy DG;Moore H;Walsh R;Reilly RB;O'Riordan S;Walsh C;Hutchinson M (2015) 'Age-Related Sexual Dimorphism in Temporal Discrimination and in Adult-Onset Dystonia Suggests GABAergic Mechanisms'. Frontiers in Neurology, 6 . [DOI] [Details]
Labb¿¿ C, Ogaki K;Lorenzo-Betancor O;Carrasquillo MM;Heckman MG;McCarthy A;Soto-Ortolaza AI;Walton RL;Lynch T;Siuda J;Opala G;Krygowska-Wajs A;Barcikowska M;Czyzewski K;Dickson DW;Uitti RJ;Wszolek ZK;Ross OA (2015) 'Exonic Re-Sequencing of the Chromosome 2q24.3 Parkinson's Disease Locus'. PLoS ONE, 10 (6). [DOI] [Details]
Fearon C, Butler JS;Newman L;Lynch T;Reilly RB (2015) 'Audiovisual Processing is Abnormal in Parkinson's Disease and Correlates with Freezing of Gait and Disease Duration'. Parkinson's Disease, . [DOI] [Details]
McCarthy A, Lonergan R;Olszewska DA;O'Dowd S;Cummins G;Magennis B;Fallon EM;Pender N;Huey ED;Cosentino S;O'Rourke K;Kelly BD;O'Connell M;Delon I;Farrell M;Spillantini MG;Rowland LP;Fahn S;Craig P;Hutton M;Lynch T (2015) 'Closing the tau loop: the missing tau mutation'. Brain, 138 (Pt 10):3100-3109. [DOI] [Details]
Labb¿¿ C, Ogaki K;Lorenzo-Betancor O;Soto-Ortolaza AI;Walton RL;Rayaprolu S;Fujioka S;Murray ME;Heckman MG;Puschmann A;McCarthy A;Lynch T;Siuda J;Opala G;Rudzinska M;Krygowska-Wajs A;Barcikowska M;Czyzewski K;Sanotsky Y;Rektorov¿¿ I;McLean PJ;Rademakers R;Ertekin-Taner N;Hassan A;Ahlskog JE;Boeve BF;Petersen RC;Maraganore DM;Adler CH;Ferman TJ;Parisi JE;Graff-Radford NR;Uitti RJ;Wszolek ZK;Dickson DW;Ross OA (2015) 'Role for the microtubule-associated protein tau variant p.A152T in risk of ¿¿-synucleinopathies'. Neurology, . [DOI] [Details]
Lorenzo-Betancor O, Ogaki K;Soto-Ortolaza AI;Labbe C;Walton RL;Strongosky AJ;van Gerpen JA;Uitti RJ;McLean PJ;Springer W;Siuda J;Opala G;Krygowska-Wajs A;Barcikowska M;Czyzewski K;McCarthy A;Lynch T;Puschmann A;Rektorova I;Sanotsky Y;Vilari¿¿o-G¿¿ell C;Farrer MJ;Ferman TJ;Boeve BF;Petersen RC;Parisi JE;Graff-Radford NR;Dickson DW;Wszolek ZK;Ross OA (2015) 'DNAJC13 p.Asn855Ser mutation screening in Parkinson's disease and pathologically confirmed Lewy body disease patients'. European Journal of Neurology, 22 (9):1323-1325. [DOI] [Details]
Iovino M, Agathou S;Gonz¿¿lez-Rueda A;Del Castillo Velasco-Herrera M;Borroni B;Alberici A;Lynch T;O'Dowd S;Geti I;Gaffney D;Vallier L;Paulsen O;K¿¿rad¿¿ttir RT;Spillantini MG (2015) 'Early maturation and distinct tau pathology in induced pluripotent stem cell-derived neurons from patients with MAPT mutations'. Brain, . [DOI] [Details]
Govern EM, Judge EP;Kavanagh E;Gaine S;Lynch T (2015) 'Interferon beta related pulmonary arterial hypertension; an emerging worrying entity?'. Multiple Sclerosis and Related Disorders, 4 (3):284-286. [DOI] [Details]
Olszewska DA, Lynch T (2015) 'Will crystal parkin help in understanding the future of Parkinson's disease?'. Frontiers in Neurology, 6 . [DOI] [Details]
Molloy A, Kimmich O, Williams L, Butler JS, Byrne N, Molloy F, Moore H, Healy DG, Lynch T, Edwards MJ, Walsh C, Reilly RB, O'Riordan S, Hutchinson M (2014) 'An evaluation of the role of environmental factors in the disease penetrance of cervical dystonia'. Journal of Neurology, Neurosurgery and Psychiatry, . [DOI] [Details]
Shannon B, Soto-Ortolaza A;Rayaprolu S;Cannon HD;Labb¿¿ C;Benitez BA;Choi J;Lynch T;Boczarska-Jedynak M;Opala G;Krygowska-Wajs A;Barcikowska M;Van Gerpen JA;Uitti RJ;Springer W;Cruchaga C;Wszolek ZK;Ross OA (2014) 'Genetic variation of the retromer subunits VPS26A/B-VPS29 in Parkinson's disease'. Neurobiology of Aging, 35 (8):19580-19582. [DOI] [Details]
Allen NM, Lin JP;Lynch T;King MD (2014) 'Status dystonicus: a practice guide'. Developmental Medicine and Child Neurology, 56 (2):105-112. [DOI] [Details]
McCarthy A, McKinley J;Lynch T (2014) 'Putting the downstream breaks on neurodegeneration?'. Movement Disorders, 29 (2). [DOI] [Details]
Olszewska DA, Fearon C;Lynch T (2014) 'New Perception of Mitochondrial Regulatory Pathway in Parkinsonism - Ubiquitin, PINK1, and Parkin'. Frontiers in Neurology, 5 . [DOI] [Details]
Salomone S, Robertson IH;Lynch T;Balsters JH;Fearon C;Marnane M;Pender NP;Dockree PM (2014) 'The effects of immunologic brainstem encephalopathy on cognitive function following awakening from a progressive autoimmune coma'. Neurocase, 20 (5):569-580. [DOI] [Details]
Hutchinson M, Isa T, Molloy A, Kimmich O, Williams L, Molloy F, Moore H, Healy DG, Lynch T, Walsh C, Butler J, Reilly RB, Walsh R, O'Riordan S (2014) 'Cervical dystonia: a disorder of the midbrain network for covert attentional orienting'. Frontiers in Neurology, 5 . [DOI] [Details]
Kimmich O, Molloy A, Whelan R, Williams L, Bradley D, Balsters J, Molloy F, Lynch T, Healy DG, Walsh C, O'Riordan S, Reilly RB, Hutchinson M (2014) 'Temporal discrimination, a cervical dystonia endophenotype: penetrance and functional correlates'. Movement Disorders, 29 (6):804-811. [DOI] [Details]
McKinley JJ, McCarthy A, Kavanagh E, Lynch T (2013) 'Neurological ornithology'. Journal of Neurology, Neurosurgery and Psychiatry, . [DOI] [Details]
Graham D, McCarthy A, Kavanagh E, O'Rourke K, Lynch T (2013) 'Teaching NeuroImages: longitudinally extensive transverse myelitis in neuro-Behcet disease'. Urology, 80 (18):1-90. [DOI] [Details]
McCarthy A, Farrell M, Hedley-Whyte T, McGuone D, Kavanagh E, McNally S, Keogan M, Horgan N, Lynch T, O'Rourke K (2013) 'Granulomatosis with polyangiitis masquerading as giant cell arteritis'. Neurology, 260 (6):1661-1663. [DOI] [Details]
Hutchinson M, Kimmich O, Molloy A, Whelan R, Molloy F, Lynch T, Healy DG, Walsh C, Edwards MJ, Ozelius L, Reilly RB, O'Riordan S (2013) 'The endophenotype and the phenotype: temporal discrimination and adult-onset dystonia'. Movement Disorders, 28 (13):1766-1774. [DOI] [Details]
Kearney H, O'Dowd S, Murray B, Kavanagh E, O'Connell M, Lynch T (2012) 'Re-emergence of artistic traits in a patient with frontotemporal dementia'. Clinical Neurology and Neurosurgery, 114 (4):417-420. [DOI] [Details]
Mulroy E, Quigley G, Roberts K, Cummins G, Magennis B, Fortune G, O'Brien D, Blunnie WP, Harrington E, Gillivan-Murphy P, Kavanagh E, Gilligan P, Reilly R, Scolaí PO, Kelly S, Murray M, Lynch T (2012) 'Deep brain stimulation in ireland for Parkinson's disease and essential tremor'. Irish Medical Journal, 105 (8):278-280. [Details]
Kearney H, Murray B, Kavanagh E, O'Rourke K, Kelly P, Lynch T (2011) 'Autoimmune encephalopathy presenting as a 'posterior circulation stroke''. Neurology, 258 (2):330-332. [DOI] [Details]
Chartier-Harlin MC, Dachsel JC, Vilariño-Güell C, Lincoln SJ, Leprêtre F, Hulihan MM, Kachergus J, Milnerwood AJ, Tapia L, Song MS, Le Rhun E, Mutez E, Larvor L, Duflot A, Vanbesien-Mailliot C, Kreisler A, Ross OA, Nishioka K, Soto-Ortolaza AI, Cobb SA, Melrose HL, Behrouz B, Keeling BH, Bacon JA, Hentati E, Williams L, Yanagiya A, Sonenberg N, Lockhart PJ, Zubair AC, Uitti RJ, Aasly JO, Krygowska-Wajs A, Opala G, Wszolek ZK, Frigerio R, Maraganore DM, Gosal D, Lynch T, Hutchinson M, Bentivoglio AR, Valente EM, Nichols WC, Pankratz N, Foroud T, Gibson RA, Hentati F, Dickson DW, Destée A, Farrer MJ (2011) 'Translation initiator EIF4G1 mutations in familial Parkinson disease'. American Journal of Human Genetics, 89 (3):398-406. [DOI] [Details]
Walsh R, O'Dwyer JP, Sheikh IH, O'Riordan S, Lynch T, Hutchinson M (2007) 'Sporadic adult onset dystonia: sensory abnormalities as an endophenotype in unaffected relatives'. Journal of Neurology, Neurosurgery and Psychiatry, 78 (9):980-983. [DOI] [Details]
Costello DJ, Renganathan R, O'Hare A, Murray B, Lynch T; (2005) 'Audit of an inpatient neurology consultation service in a tertiary referral centre: value of the consulting neurologist'. Irish Medical Journal, 98 (5):134-137. [Details]
O'Dwyer JP, O'Riordan S, Saunders-Pullman R, Bressman SB, Molloy F, Lynch T, Hutchinson M (2005) 'Sensory abnormalities in unaffected relatives in familial adult-onset dystonia'. Urology, 65 (6):938-940. [DOI] [Details]
O'Riordan S, Ozelius LJ, de Carvalho Aguiar P, Hutchinson M, King M, Lynch T (2004) 'Inherited myoclonus-dystonia and epilepsy: further evidence of an association?'. Movement Disorders, 19 (12):1456-1459. [DOI] [Details]
O'Riordan S, Lynch T, Hutchinson M (2004) 'Familial adolescent-onset scoliosis and later segmental dystonia in an Irish family'. Neurology, 251 (7):845-848. [DOI] [Details]
Hutchinson M, Galvin R, Sweeney B, Lynch T, Murphy R, Redmond J (2004) 'Effect of a multidisciplinary clinic on survival in amyotrophic lateral sclerosis'. Journal of Neurology, Neurosurgery and Psychiatry, 75 (8):1208-121. [Details]