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Miriam Tosetto

Senior Research Assistant

School Of Medicine
St Vincent's Hospital
Elm Park
Dublin 4

Tel: 2214916
Email: mtosetto@ucd.ie

Biography

2001-2002 Bird Foundation Europe Onlus Institute for Rare Diseases ¿M. Baschirotto¿, Vicenza, Italy Scholarship - Research and Diagnostic on rare diseases.

 

2004 -at present Centre for Colorectal Disease, Education & Research Centre, St. Vincent¿s University Hospital, University College Dublin

My role would include the coordination and management of day to day activities of the colorectal research group. This involves the organisation of the lab, bio-banking and lab maintenance as part of a multi-disciplinary centre. I am also involved in development and setting up of multiple research projects within the group

Professional

         

Conference Contributions

Tosetto, M., Allen, L. T., Dawson, K. A., and Gallagher, W. M. presented by M. Tosetto.; (2003) Cell-biomaterial interactions: evaluation of biological responses to chiral polymers. [Poster Presentation], Irish Association of Pharmacologists 14th Annual Meeting, Dublin , 10-OCT-03.
Tosetto, M., Allen, L. T., Dawson, K. A., and Gallagher, W. M. presented by M. Tosetto.; (2003) Cell-biomaterial interactions: evaluation of biological responses to chiral polymers. [Poster Presentation], 3rd Annual Conway Institute Festival of Research, University College Dublin , 10-SEP-03 - 11-SEP-03.
   

Education

Year 2004 Institution: UCD
Qualification: MSc Subject: Pharmacology on cell-biomaterial interaction
Year 2000 Institution: Universita degli studi di Padova
Qualification: BSc Subject: Chemistry: Specialising in Organic-Biological chemistry
         

Publications

     

Peer Reviewed Journals

Dunne MR, Ryan C;Nolan B;Tosetto M;Geraghty R;Winter DC;O'Connell PR;Hyland JM;Doherty GA;Sheahan K;Ryan EJ;Fletcher JM (2016) 'Enrichment of Inflammatory IL-17 and TNF-¿¿ Secreting CD4(+) T Cells within Colorectal Tumors despite the Presence of Elevated CD39(+) T Regulatory Cells and Increased Expression of the Immune Checkpoint Molecule, PD-1'. Frontiers in Oncology, 6 . [DOI] [Details]
Gibson DJ, Elliott L, McDermott E, Tosetto M, Keegan D, Byrne K, Martin ST, Rispens T, Cullen G, Mulcahy HE, Cheifetz AS, Moss AC, Robson SC, Doherty GA, Ryan EJ (2015) 'Heightened Expression of CD39 by Regulatory T Lymphocytes Is Associated with Therapeutic Remission in Inflammatory Bowel Disease'. Inflammatory Bowel Diseases, . [DOI] [Details]
McDermott E, Ryan EJ;Tosetto M;Gibson D;Burrage J;Keegan D;Byrne K;Crowe E;Sexton G;Malone K;Harris RA;Kellermayer R;Mill J;Cullen G;Doherty GA;Mulcahy H;Murphy TM (2015) 'DNA methylation profiling in inflammatory bowel disease provides new insights into disease pathogenesis'. Journal of Crohn's and Colitis, . [DOI] [Details]
O'Toole A, Michielsen AJ, Nolan B, Tosetto M, Sheahan K, Mulcahy HE, Winter DC, Hyland JM, O'Connell PR, Fennelly D, O'Donoghue D, O'Sullivan J, Doherty GA, Ryan EJ (2014) 'Tumour microenvironment of both early- and late-stage colorectal cancer is equally immunosuppressive'. British Journal of Cancer, . [DOI] [Details]
Martin P, Noonan S, Mullen MP, Scaife C, Tosetto M, Nolan B, Wynne K, Hyland J, Sheahan K, Elia G, O'Donoghue D, Fennelly D, O'Sullivan J. (2014) 'Predicting response to vascular endothelial growth factor inhibitor and chemotherapy in metastatic colorectal cancer'. BMC Cancer, 14 (887). [DOI] [Details]
Sheridan J, Tosetto M;Gorman J;O'Donoghue D;Sheahan K;Hyland J;Mulcahy H;Gibbons D;O'Sullivan J (2013) 'Effects of radiation on levels of DNA damage in normal non-adjacent mucosa from colorectal cancer cases'. Journal of Gastrointestinal Cancer, 44 (1):41-45. [DOI] [Details]
Michielsen, A. J., Noonan, S., Martin, P., Tosetto, M., Marry, J., Biniecka, M., Maguire, A. A., Hyland, J. M., Sheahan, K. D., O'Donoghue, D. P., Mulcahy, H. E., Fennelly, D., Ryan, E. J., O'Sullivan, J. N. (2012) 'Inhibition of dendritic cell maturation by the tumor microenvironment correlates with the survival of colorectal cancer patients following bevacizumab treatment'. Molecular Cancer Therapy, 11 (8):1829-37. Available Online [Details]
Kevans D, Gorman S;Tosetto M;Sheahan K;O'Donoghue D;Mulcahy H;O'Sullivan J (2012) 'Clusterin and chemotherapy sensitivity under normoxic and graded hypoxic conditions in colorectal cancer'. Journal of Gastrointestinal Cancer, 43 (2):305-313. [DOI] [Details]
Michielsen, A. J., Hogan, A. E., Marry, J., Tosetto, M., Cox, F., Hyland, J. M., Sheahan, K. D., O'Donoghue, D. P., Mulcahy, H. E., Ryan, E. J., O'Sullivan, J. N. (2011) 'Tumour tissue microenvironment can inhibit dendritic cell maturation in colorectal cancer'. PLoS One, 6 (11). Available Online [Details]
Prencipe M, Fitzpatrick P, Gorman S, Tosetto M, Klinger R, Furlong F, Harrison M, O'Connor D, Roninson IB, O'Sullivan J, McCann A; (2009) 'Cellular senescence induced by aberrant MAD2 levels impacts on paclitaxel responsiveness in vitro'. British Journal of Cancer, 101 (11):1900-1908. [DOI] [Details]
Coss A, Tosetto M, Fox EJ, Sapetto-Rebow B, Gorman S, Kennedy BN, Lloyd AT, Hyland JM, O'Donoghue DP, Sheahan K, Leahy DT, Mulcahy HE, O'Sullivan JN ; (2009) 'Increased topoisomerase IIalpha expression in colorectal cancer is associated with advanced disease and chemotherapeutic resistance via inhibition of apoptosis'. Cancer Letters, 276 :228-238. [Details]
McCann A, Watson JA, Watson CJ, McCrohan AM, Woodfine K, Tosetto M, McDaid J, Gallagher E, Betts D, Baugh J, O'Sullivan J, Murrell A, Watson RW, ; (2009) 'Generation of an epigenetic signature by chronic hypoxia in prostate cells'. Human Molecular Genetics, 18 (19):3594-3604. [DOI] [Details]
Sullivan S, Tosetto M;Kevans D;Coss A;Wang L;O'Donoghue D;Hyland J;Sheahan K;Mulcahy H;O'Sullivan J (2009) 'Localization of nuclear cathepsin L and its association with disease progression and poor outcome in colorectal cancer'. International Journal of Cancer, 125 (1):54-61. [DOI] [Details]
Sheridan J, Wang LM;Tosetto M;Sheahan K;Hyland J;Fennelly D;O'Donoghue D;Mulcahy H;O'Sullivan J (2009) 'Nuclear oxidative damage correlates with poor survival in colorectal cancer'. British Journal of Cancer, 100 (2):381-388. [DOI] [Details]
Gorman S, Tosetto M;Lyng F;Howe O;Sheahan K;O'Donoghue D;Hyland J;Mulcahy H;O'Sullivan J (2009) 'Radiation and chemotherapy bystander effects induce early genomic instability events: telomere shortening and bridge formation coupled with mitochondrial dysfunction'. Mutation Research, 669 (1-2):131-138. [DOI] [Details]
                           

Abstract

Noonan, S,Martin, P,Maguire, A,Biniecka, M,Tosetto, M,Hyland, J,Sheahan, K,O'Donoghue, D,Mulcahy, H,Fennelly, D,O'Sullivan, J (2012) Correlation of markers of oxidative damage and circulating IL6 levels with survival following treatment with bevacizumab in metastatic colorectal cancer patients. Abstract [Details]
                                                               

Research

Research Interests

UCD Medicine Research Group: Colorectal