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Researchers at UCD

Alistair Nichol

Consultant Anaesthetist - Icu.

School of Medicine
Department of Critical Care
St. Vincents University Hospital
Elm Park
Dublin 4

Tel: +353 1 721 5053
Email: alistair.nichol@ucd.ie

Professional

         

Conference Contributions

Nichol, A., Howell, K. and McLoughlin, P.; (2005) Membrane Channels. [Poster Presentation], Physiological Society, Oxford , 05-SEP-05 - 07-SEP-05.
Nichol A, O¿Croinin D, Naughton F, Boylan J, McLoughlin P; (2008) Buffered Hypercapnia worsens E coli induced Lung Injury in vivo. [Peer Reviewed Published Proceedings], American Thoracic Society International Conference, .
Nichol, A., Howell, K., Costello, C. & McLoughlin, P.; Hypoxia Conference. [Poster Presentation], Keystone Symposium, Breckenridge, Colorado, USA .

Committees

Committee : ISARIC WP
Committee : Management Committee of 4 large internation Multicentre RCTS
Committee : PREPARE WP
           

Other Activities

  Research students
a.       UCD Summer medical student project (1)

b.      UCD Engineering student project (3)

c.       3 registrar projects

d.      MD research project (commencing Jan 2014)

 

Publications

     

Peer Reviewed Journals

French C;Little L;Presneill J;Cooper DJ;Haddad S;Duranteau J;Huet O;Skrifvars M;Arabi Y;Bellomo R;, Nichol A (2015) 'Erythropoietin in traumatic brain injury: study protocol for a randomised controlled trial'. Trials, 16 . [DOI] [Details]
Nichol A, Gantner D;Presneill J;Murray L;Trapani T;Bernard S;Cameron P;Capellier G;Forbes A;McArthur C;Newby L;Rashford S;Rosenfeld JV;Smith T;Stephenson M;Varma D;Walker T;Webb S;Cooper DJ (2015) 'Protocol for a multicentre randomised controlled trial of early and sustained prophylactic hypothermia in the management of traumatic brain injury'. Critical Care Medicine, 17 (2):92-100. [Details]
Presneill J, Little L;Nichol A;French C;Cooper DJ;Haddad S;Duranteau J;Huet O;Skrifvars M;Arabi Y;Bellomo R; ; (2015) 'Statistical analysis plan for the Erythropoietin in Traumatic Brain Injury trial: a randomised controlled trial of erythropoietin versus placebo in moderate and severe traumatic brain injury'. Trials, 15 . [DOI] [Details]
Kaukonen KM, Bailey M;Ady B;Aubron C;French C;Gantner D;Irving D;Murray L;Nichol A;Pettil¿¿ V;McQuilten Z;Cooper DJ (2014) 'A randomised controlled trial of standard transfusion versus fresher red blood cell use in intensive care (TRANSFUSE): protocol and statistical analysis plan'. Critical Care Medicine, 16 (4):255-261. [Details]
Aubron C, Nichol A, Cooper DJ, Bellomo R (2013) 'Age of red blood cells and transfusion in critically ill patients'. Annals of Intensive Care, 3 (1). [DOI] [Details]
Kruger P, Bailey M, Bellomo R, Cooper DJ, Harward M, Higgins A, Howe B, Jones D, Joyce C, Kostner K, McNeil J, Nichol A, Roberts MS, Syres G, Venkatesh B (2013) 'A multicenter randomized trial of atorvastatin therapy in intensive care patients with severe sepsis'. Critical Care Medicine, 187 (7):743-750. [DOI] [Details]
Hodgson C, Carteaux G, Tuxen DV, Davies AR, Pellegrino V, Capellier G, Cooper DJ, Nichol A (2013) 'Hypoxaemic rescue therapies in acute respiratory distress syndrome: Why, when, what and which one?'. Injury, 44 (12):1700-1709. [DOI] [Details]
Moore EM, Bellomo R, Nichol AD (2012) 'The meaning of acute kidney injury and its relevance to intensive care and anaesthesia'. Anaesthesia and Intensive Care, 40 (6):929-948. [Details]
Hodgson, CL,Hayes, K,Everard, T,Nichol, A,Davies, AR,Bailey, MJ,Tuxen, DV,Cooper, DJ,Pellegrino, V (2012) 'Long-term quality of life in patients with acute respiratory distress syndrome requiring extracorporeal membrane oxygenation for refractory hypoxaemia'. Journal of Critical Care, 16 . [DOI] [Details]
Nichol AD, O'Cronin D F, Naughton F, Hopkins N, Boylan J, McLoughlin P.; (2010) 'Hypercapnic acidosis reduces oxidative reactions in endotoxin-induced lung injury'. Anesthesiology, 113 (1):116-125. [DOI] [Details]
Nichol, AD,O'Cronin, DF,Howell, K,Naughton, F,O'Brien, S,Boylan, J,O'Connor, C,O'Toole, D,Laffey, JG,McLoughlin, P; (2009) 'Infection-induced lung injury is worsened after renal buffering of hypercapnic acidosis'. Critical Care Medicine, 37 :2953-2961. [DOI] [Details]
O'Croinin, DF, Nichol, AD, Hopkins, N, Boylan, JF, O'Brien S, O'Connor, C, Laffey, JG, McLoughlin, P; (2008) 'Sustained hypercapnic acidosis during pulmonary infection increases bacterial load and worsens lung injury'. Critical Care Medicine, 36 (7):2128-2135. [DOI] [Details]
Hyvelin JM, Howell K, Nichol A, Costello CM, Preston RJ, McLoughlin P.; (2005) 'Inhibition of Rho-kinase attenuates hypoxia-induced angiogenesis in the pulmonary circulation'. Circulation Research, 97 (2):185-191. [Details]
 

Conference Publications

Nichol A, O'Croinin D, Naughton F, Boylan J, McLoughlin P; (2008) Buffered Hypercapnia worsens E coli induced Lung Injury in vivo American Thoracic Society International Conference [Details]
Nichol A, Naughton F, OCroinin D, McLoughlin P; (2007) Buffered Hypercapnia worsens lung injury in endotoxin induced pneumonia American Thoracic Society International Conference [Details]
Nichol, A., Naughton, F., O`Cronin, D., Boylan, J., Laffey, J. Mc Loughlin, P.; (2006) Buffered hypercapnia worsens lung injury in endotoxin induced lung injury College of Anaesthetists [Details]
Nichol, A., Howell, K., Costello, C. McLoughlin, P.; (2006) Reversal of vasoconstriction in chronically hypoxic hypertensive lungs does not alter the alveolar arterial oxygen gap Keystone Conferrnce [Details]
Nichol, A., O`Cronin, D., Naughton, F. McLoughlin, P.; (2005) Hypercapnia does not attenuate oxidation in endotoxin induced Acute Lung Injury Irish Thoracic Socitey [Details]
Nichol, A., Howell, K. Mc Loughlin, P.; (2005) Reversal of vasoconstriction in chronically hypoxic hypertensive lungs does not alter the alveolar arterial oxygen gap Physiological Society Smooth Muscle Symposium [Details]
   

Editorial

Nichol, A; (2007) High-frequency oscillation in acute respiratory distress syndrome: Who rescues the rescuer?. Editorial [DOI] [Details]
                                                                                   

Research

Research Interests

1.          Grants

(a)      EU FP-7  PREPARE ¿24,000,000.00 (UCD ¿562,727.00)

(b)      ANZCA   Lung recruitment: PHARLAP Sub-studyAUD $ 34,000.00

(c)       ICSI Travel award ¿2,500.00

(d)      HRB- MRCGPHARLAP Study- ¿82,860.69

(e)      SVUH Summer student scholarship ¿1,000

 

2.          Research Projects / Collaborations in SVUH

(a)      ARISE RCT- Collab with ED- 3 patients recruited

(b)      PHARLAP- ethics approval but contracts pending

(c)       TRANSFUSE- collab with haem / blood bank, ethics approval but contracts pending

(d)      SCOTCH study- collab with hepatology

(e)      Collab with endocrinology GLP study

(f)       COMBACTE- IMI collaboration + linked with Mater

(g)      SVUH- Lung safe (ESICM)

(h)      SVUH- National Co-0rdinator IC-GLOSARRI (ESICM)

 

3.          Links with MATER / DUBLIN EAST

(a)      Regular 6 weekly meeting Research / Training / Clinical / Transport
Dublin East group Research / Training / Clinical / Transport

                      

Research Projects

Sponsor : Health Research Board (HRB)
Title : Translating Critical Care Research into Clinical Practice
Start Date / End Date : 01-DEC-15 / 30-NOV-16
Sponsor : Intensive Care Society of Ireland
Title : Hypercapnic Acidosis and Peroynitrite
Start Date / End Date : 01-DEC-04 / 30-NOV-06
Sponsor : Health Research Board (HRB)
Title : Improving Outcomes after Critical Illness
Start Date / End Date : 19-JUN-14 / 19-SEP-14
Sponsor : Enterprise Ireland (EI)
Title : Horizon 2020 travel support
Start Date / End Date : 22-NOV-13 / 22-AUG-14
Sponsor : EC Framework (FP7)
Title : Platform foR European Preparedness Against (Re-)emerging Epidemics (PREPARE)
Start Date / End Date : 01-FEB-14 / 31-JAN-19
Sponsor : Health Research Board (HRB)
Title : STandaRd Issue TrANsfusion versuS Fresher red blood cell Use in intenSive carE (TRANSFUSE) - a randomised controlled trial.
Start Date / End Date : 06-OCT-14 / 02-FEB-19
Sponsor : Health Research Board (HRB)
Title : Improving Outcomes after Critical Illness
Start Date / End Date : 18-MAY-15 / 17-MAY-20
Sponsor : University College Dublin Foundation Ltd.
Title : Research Activities of Professor Alistair Nichol in the UCD School of Medicine and Medical Science
Start Date / End Date : 01-APR-15 / 31-MAR-20
 

Current Postgraduate Students

David Cosgrave, Medicine (MD)   -   Thesis Supervisor
Memon Fazal Illahi, Medicine (MD)   -   Thesis Supervisor
Prasanth Sukumar, Doctor of Philosophy (PhD)   -   Thesis Co-Supervisor