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Researchers at UCD

researcher

Bill Watson

Conway Fellow & Director Biomedical Health and Life Science Honours Bsc Degree

School of Medicine
Conway Institute
Belfield
Dublin 4

Tel: 353 1 716 6733
Email: william.watson@ucd.ie

Biography

Professor Watson received his PhD degree in Biochemistry from the Department of Biochemistry, University College Cork in 1995. He then undertook his post-doctoral research in University of Toronto and the Toronto General Hospital in Canada, before returning in 1997, to the Department of Surgery, Mater Misericordiae University Hospital as a college Lecturer in University College Dublin. He is now Professor of Cancer Biology in the UCD School of Medicine, University College Dublin. Apart from his undergraduate and post-graduate teaching responsibilities, he has an active internationally recognised research group. As a translational biologist based in the Conway Institute he utilises latest technologies to study cellular and molecular pathways and clinical collaboration through the Prostate Cancer Research Consortium (of which he is the lead PI) to expand the understanding of the initiation and progression of prostate cancer in order to identify diagnostic and prognostic biomarkers and therapeutic sites for manipulation. 

Professional

Honours and Awards

Year: 2000.
Title: Alton Prize
Year: 2000.
Title: Presidents Award
Year: 1998.
Title: Presidents Award
Year: 1997.
Title: Post Doctoral Travel Award
Year: 1996.
Title: William O'Keeffe Memorial Prize
Year: 1996.
Title: Post Doctoral Travel Award
Year: 1995.
Title: Student Travel Award
Year: 1995.
Title: Young Investigator Award
Year: 1995.
Title: Council prize
Year: 1993.
Title: Shepherd Trust prize. Royal College of Surgeons in Ireland
Year: 1990.
Title: Mayo Clinic, Undergraduate Research Fellowship

Associations

Association: European Association of Urology Research Foundation - Basic Science, Function/Role: Chair
Association: Irish Association for Cancer Research, Function/Role: President
     

Conference Contributions

Watson, W (2015) The role of ZEB1 in EMT and docetaxel resistance in advanced prostate cancer. [Invited Lecture], 2nd Annual Meeting of Matrix Biology Ireland, UCD , 02-DEC-15 - 04-DEC-15.
Watson, W (2015) Biomarkers for decision-making in early stage disease. [Invited Lecture], Prostate Cancer Collaborative Research, Brisbane, Australia , 25-NOV-15 - 28-NOV-15.

Committees

Committee : Movember Global Action Plan Scientific Advisory Committee
Committee : Prostate Cancer UK Scientific Committee
Committee : Biomedical Health and Life Science BSc Degree

Employment

Employer: Royal College of Surgeons in Ireland
Position: Ph.D. Student
Employer: University of Toronto and Toronto General Hospital
Position: Post Doctoral Research Fellow
Employer: University College Dublin
Position: College Lecturer

Education

Year 1991 Institution: University College Dublin
Qualification: BSc Subject:
Year 1995 Institution: Royal Coll Surgeons in Ireland
Qualification: PhD Subject:
Year 1992 Institution: Dublin Institute of Technology (DIT), IRL
Qualification: GRSC Subject:
     

Journals Edited

Bju International: Editorial Advisory Board Member.

Other Activities

Chair, Organising Committee of the 7th World Basic Urological Research Congress January 2005 - present. This is the Joint meeting of the European Society for Urological Research and the Society for Basic Urologic Research in the US which will be hosted in UCD on the 27-29th September 2007.

Publications

 

Book Chapters

Foley, R., DiFranco, M., Bryan, K., Rexhepaj, E., Mulrane, L., Watson, W., Cunningham, P. and Gallagher, W. ; (2008) 'Automated Image Analysis Approaches in Histopathology' In: Foley, R., DiFranco, M., Bryan, K., Rexhepaj, E., Mulrane, L., Watson, W., Cunningham, P. and Gallagher, W. ; (eds). Handbook of Research on Systems Biology Applications in Medicine. Hershey, Pennsylvania: IGI Global. [Details]
Walsh, S.E., Fitzpatrick, J.M. Watson, R.W.G.; (2006) 'Apoptosis and prostate cancer' In: Walsh, S.E., Fitzpatrick, J.M. Watson, R.W.G.; (eds). Prostate Cancer Principles and Practice. London: Taylor & Francis. [Details]
Watson R.W.G., McLornan L., McEleny K., Fitzpatrick J.M.; (2003) 'Update on the regulation of apoptosis in prostate Cancer' In: J. Mydlo (eds). Prostate Cancer. , pp.45-53 [Details]
Morrissey C., Watson R.W.G, Fitzpatrick J.M.; (2003) 'Apoptosis in the Prostate' In: Kirby R. and OLeary M (eds). Hot Topics in Urology. [Details]
Watson R.W.G., Coffey R., Fitzpatrick J.M.; (2000) 'Future Trends in Basic Research: Apoptosis as a target' In: A. Belldegrun, R. Kirby and D.W.W. Newling (eds). New Perspectives in Prostate Cancer. , pp.115-125 [Details]
Watson R.W.G.; (1998) 'Apoptosis: Its role in the systemic inflammatory response syndrome and the involvement of cytokines' In: H. Redl and G. Schlaged (eds). Cytokines in severe sepsis and septic shock. , pp.213-226 [Details]
MarshallJ. C., Watson R.W.G.; (1997) 'Apoptosis in the resolution of systemic inflammation' In: * (eds). Yearbook in Intensive Care and Emergency Medicine. , pp.100-108 [Details]
 

Peer Reviewed Journals

Foley, R.W., Gorman, L.V., Sharifi, N., Lundon, D.J., Murphy, K., Moore, H., Tuzova, A., Perry, A., Murphy, T.B. and Watson, R.W.G. (2016) 'Improving Multivariable Prostate Cancer Risk Assessment Using The Prostate Health Index'. BJU International, 117 (3):409-417. [DOI] [Details]
Foley RW, Maweni RM;Gorman L;Murphy K;Lundon DJ;Durkan G;Power R;O'Brien F;O'Malley KJ;Galvin DJ;Murphy TB;Watson RW (2016) 'The ERSPC Risk Calculators Significantly Outperform The PCPT 2.0 In The Prediction Of Prostate Cancer; A Multi-Institutional Study'. BJU International, . [DOI] [Details]
Lundon, D. J. and Kelly, B. D. and Foley, R. and Loeb, S. and Fitzpatrick, J. M. and Watson, R. W. G. and Rogers, E. and Durkan, G. C. and Walsh, K. (2015) 'Prostate cancer risk assessment tools in an unscreened population'. WORLD JOURNAL OF UROLOGY, 33 (6):827-832. [DOI] [Details]
Johnson IR, Parkinson-Lawrence EJ, Keegan H, Spillane CD, Barry-O'Crowley J, Watson WR, Selemidis S, Butler LM, O'Leary JJ, Brooks DA (2015) 'Endosomal Gene expression: a new indicator for prostate cancer patient prognosis?'. Oncotarget, 6 (36):37919-37929. [DOI] [Details]
Foley RW, Lundon DJ;Murphy K;Murphy TB;Galvin DJ;Watson RW (2015) 'Predicting prostate cancer: analysing the clinical efficacy of prostate cancer risk calculators in a referral population'. Irish Journal of Medical Science, 184 (3):701-706. [DOI] [Details]
Onwuneme C, Blanco A;O'Neill A;Watson B;Molloy EJ (2015) 'Vitamin D enhances Reactive Oxygen Intermediates Production in Phagocytic Cells in Term and Preterm Infants'. Pediatric Research, . [DOI] [Details]
Prencipe M, O'Neill A;O'Hurley G;Nguyen LK;Fabre A;Bjartell A;Gallagher WM;Morrissey C;Kay EW;Watson RW (2015) 'Relationship between serum response factor and androgen receptor in prostate cancer'. Prostate, 75 (15):1704-1717. [DOI] Link to full text [Details]
Wekesa A, Harrison M;Watson RW (2015) 'Physical activity and its mechanistic effects on prostate cancer'. Prostate Cancer and Prostatic Diseases, 18 (3):197-207. [DOI] [Details]
Murphy L, Prencipe M;Gallagher WM;Watson RW (2015) 'Commercialized biomarkers: new horizons in prostate cancer diagnostics'. Expert Review of Molecular Diagnostics, 15 (4):491-503. [DOI] Link to full text [Details]
O'Hare FM, Watson RW;O'Neill A;Blanco A;Donoghue V;Molloy EJ (2015) 'Persistent systemic monocyte and neutrophil activation in neonatal encephalopathy'. Journal of Maternal-Fetal and Neonatal Medicine, :1-8. [DOI] [Details]
O'Hare FM, Watson W;O'Neill A;Grant T;Onwuneme C;Donoghue V;Mooney E;Downey P;Murphy J;Twomey A;Molloy EJ (2015) 'Neutrophil and monocyte toll-like receptor 4, CD11b and reactive oxygen intermediates, and neuroimaging outcomes in preterm infants'. Pediatric Research, 78 (1):82-90. [DOI] [Details]
Eliwan HO, Watson RW;Aslam S;Regan I;Philbin B;O'Hare FM;O'Neill A;Preston R;Blanco A;Grant T;Nolan B;Smith O;Molloy EJ (2015) 'Neonatal brain injury and systemic inflammation: modulation by activated protein C ex vivo'. Clinical and Experimental Immunology, 179 (3):477-484. [DOI] [Details]
Evans JC, McCarthy J, Torres-Fuentes C, Cryan JF, Ogier J, Darcy R, Watson RW, O'Driscoll CM. (2015) 'Cyclodextrin mediated delivery of NF-κB and SRF siRNA reduces the invasion potential of prostate cancer cells in vitro'. Gene Therapy, . [Details]
Gallagher MF, Salley Y, Spillane CD, Ffrench B, El Baruni S, Blacksheilds G, Smyth P, Martin C, Sheils O, Watson W, O'Leary JJ. (2015) 'Enhanced regulation of cell cycle and suppression of osteoblast differentiation molecular signatures by prostate cancer stem-like holoclones'. J Clin Pathol, . [Details]
O'Hurley G, Prencipe M, Lundon D, O'Neill A, Boyce S, O'Grady A, Gallagher WM, Morrissey C, Kay EW, Watson RW (2014) 'The analysis of serum response factor expression in bone and soft tissue prostate cancer metastases'. Prostate, 74 (3):306-313. [DOI] Link to full text [Details]
Boyce, S., Fan, Y., Watson, R.W. and Murphy, T.B. (2013) 'Evaluation of prediction models for the staging of prostate cancer'. BMC Medical Informatics and Decision Making, 13 :126. [DOI] [Details]
Prencipe M, Madden SF, O'Neill A, O'Hurley G, Culhane A, O'Connor D, Klocker H, Kay EW, Gallagher WM, Watson WR (2013) 'Identification of transcription factors associated with castration-resistance: is the serum responsive factor a potential therapeutic target?'. Prostate, 73 (7):743-753. [DOI] [Details]
Kennedy SA, McEllistrem B, Kinsella A, Fan Y, Boyce S, Murphy K, McCarthy JF, Wood AE, Watson RW. (2012) 'EuroSCORE and neutrophil adhesion molecules predict outcome post-cardiac surgery'. European Journal of Clinical Investigation, 42 (8):881-890. Available Online [Details]
O'Connell K, Prencipe M, O'Neill A, Corcoran C, Rani S, Henry M, Dowling P, Meleady P, O'Driscoll L, Watson W, O'Connor R (2012) 'The use of LC-MS to identify differentially expressed proteins in docetaxel-resistant prostate cancer cell lines'. Proteomics, 12 (13):2115-2126. [DOI] [Details]
Raza, A., Kennedy, S., Fan, Y., Maher, B., Codd, M., Murphy, T., Wood, A. and Watson, W. (2012) 'Anti Inflammatory Effects of Statins in Cardiac Surgery Patients'. World Journal of Cardiovascular Surgery, 2 (September):40-47. [DOI] [Details]
Corcoran, C,Rani, S,O'Brien, K,O'Neill, A,Prencipe, M,Sheikh, R,Webb, G,McDermott, R,Watson, W,Crown, J,O'Driscoll, L (2012) 'Docetaxel-Resistance in Prostate Cancer: Evaluating Associated Phenotypic Changes and Potential for Resistance Transfer via Exosomes'. PLoS ONE, 7 . [DOI] [Details]
Oon, SF,Fanning, DM,Fan, Y,Boyce, S,Murphy, TB,Fitzpatrick, JM,Watson, RW (2012) 'The identification and internal validation of a preoperative serum biomarker panel to determine extracapsular extension in patients with prostate cancer'. Prostate, 72 :1523-1531. [DOI] [Details]
Murphy, L,Watson, RW (2012) 'Patented prostate cancer biomarkers'. Nature Reviews Urology, 9 :464-472. [DOI] [Details]
Bellmunt, J,Attard, G,Bahl, A,Huland, H,Klotz, L,Kuban, D,Oudard, S,Watson, W (2012) 'Advances in the management of high-risk localised and metastatic prostate cancer'. BJU International, 109 :8-13. [DOI] [Details]
Oon SF, Pennington SR, Fitzpatrick JM, Watson RW (2011) 'Biomarker research in prostate cancer--towards utility, not futility'. Nature Reviews Urology, 8 (3):131-138. [DOI] [Details]
O'Neill AJ, Prencipe M;Dowling C;Fan Y;Mulrane L;Gallagher WM;O'Connor D;O'Connor R;Devery A;Corcoran C;Rani S;O'Driscoll L;Fitzpatrick JM;Watson RW (2011) 'Characterisation and manipulation of docetaxel resistant prostate cancer cell lines'. Molecular Cancer, 10 . [DOI] [Details]
Oon SF, Watson RW, O'Leary JJ, Fitzpatrick JM.; (2011) 'Epstein criteria for insignificant prostate cancer'. BJU international, 108 (4):518-525. [Details]
Kennedy SA, Scaife C, Dunn MJ, Wood AE, Watson RW.; (2011) 'Benefits of heat treatment to the protease packed neutrophil for proteome analysis: halting protein degradation'. Proteomics, 11 (12):2560-2564. [Details]
Cuffe, S,Dowling, CM,Claffey, J,Pampillon, C,Hogan, M,Fitzpatrick, JM,Carty, MP,Tacke, M,Watson, RWG; (2011) 'Effects of Titanocene Dichloride Derivatives on Prostate Cancer Cells, Specifically DNA Damage-Induced Apoptosis'. Prostate, 71 :111-124. [DOI] [Details]
Saldova, R,Fan, Y,Fitzpatrick, JM,Watson, RWG,Rudd, PM; (2011) 'Core fucosylation and alpha 2-3 sialylation in serum N-glycome is significantly increased in prostate cancer comparing to benign prostate hyperplasia'. Glycobiology, 21 :195-205. [DOI] [Details]
DiFranco, MD,O'Hurley, G,Kay, EW,Watson, RWG,Cunningham, P; (2011) 'Ensemble based system for whole-slide prostate cancer probability mapping using color texture features'. Computerized Medical Imaging and Graphics, 35 :629-645. [DOI] [Details]
Fan, Y,Murphy, TB,Byrne, JC,Brennan, L,Fitzpatrick, JM,Watson, RWG; (2011) 'Applying Random Forests To Identify Biomarker Panels in Serum 2D-DIGE Data for the Detection and Staging of Prostate Cancer'. Journal of Proteome Research, 10 :1361-1373. [DOI] [Details]
Kinsella, A,Raza, A,Kennedy, S,Fan, Y,Wood, AE,Watson, RW (2011) 'The impact of high-dose statin therapy on transendothelial neutrophil migration and serum cholesterol levels in healthy male volunteers'. European Journal of Clinical Pharmacology, 67 :1103-1108. [DOI] [Details]
M.R. Quinlan, P. Cronin, P.J. Daly, R.W. Watson, W. Manucha, N.G. Docherty, ; (2010) 'A gender comparison of post-obstructive injury in the rat kidney'. Kidney & blood pressure research, 33 :266. [Details]
Healy DG, Watson RW;O'Mahony U;Egan JJ;Wood AE (2010) 'Neutrophil immunosurveillance for heart transplant rejection: a prospective study'. Transplantation Proceedings, 42 (5):1788-1792. [DOI] [Details]
Fanning, DM,Fan, Y,Fitzpatrick, JM,Watson, RWG; (2010) 'External Validation of the 2007 and 2001 Partin Tables in Irish Prostate Cancer Patients'. Urologia Internationalis, 84 :174-179. [DOI] [Details]
Fanning, DM,Kay, E,Fan, Y,Fitzpatrick, JM,Watson, RWG; (2010) 'Prostate cancer grading: the effect of stratification of needle biopsy Gleason Score 4+3 as high or intermediate grade'. BJU International, 105 :631-635. [DOI] [Details]
Cuffe S, Dowling CM, Claffey J, Pampillón C, Hogan M, Fitzpatrick JM, Carty MP, Tacke M, Watson RW; (2010) 'Effects of titanocene dichloride derivatives on prostate cancer cells, specifically DNA damage-induced apoptosis'. Prostate, . [Details]
Watson RW, Kay EW, Smith D; (2010) 'Integrating biobanks: addressing the practical and ethical issues to deliver a valuable tool for cancer research'. nature review cancer, 10 (9):646-651. [Details]
Fanning, D. M.,Yue, F.,Fitzpatrick, J. M.,Watson, R. W.; (2010) 'Novel predictive tools for Irish radical prostatectomy pathological outcomes: development and validation'. Irish Journal of Medical Science, 179 (22):187-95187. Available Online [Details]
Smyth, L. G.,O'Hurley, G.,O'Grady, A.,Fitzpatrick, J. M.,Kay, E.,Watson, R. W.; (2010) 'Carbonic anhydrase IX expression in prostate cancer'. Prostate Cancer and Prostatic Diseases, 13 (22):178-81178. Available Online [Details]
Fizazi K, Sternberg CN, Fitzpatrick JM, Watson RW, Tabesh M; (2010) 'Role of targeted therapy in the treatment of advanced prostate cancer'. BJU International, 105 (6):748-767. [DOI] [Details]
Burke JP, Watson RW, Mulsow JJ, Docherty NG, Coffey JC, O'Connell PR; (2010) 'Endoglin negatively regulates transforming growth factor beta1-induced profibrotic responses in intestinal fibroblasts'. British Journal of Surgery, 97 (6):892-901. [DOI] [Details]
Burke, JP,Cunningham, MF,Watson, RWG,Docherty, NG,Coffey, JC,O'Connell, PR; (2010) 'Bacterial lipopolysaccharide promotes profibrotic activation of intestinal fibroblasts'. British Journal of Surgery, 97 :1126-1134. [DOI] [Details]
Girard, FP,Byrne, J,Downes, M,Fanning, D,Desgrandchamps, F,Fitzpatrick, JM,Watson, RW; (2010) 'Detecting soluble Clusterin in in-vitro and in-vivo models of prostate cancer'. Neoplasma, 57 :488-493. [DOI] [Details]
O'Hurley, G,O'Grady, A,Smyth, P,Byrne, J,O'Leary, JJ,Sheils, O,Watson, RWG,Kay, EW; (2010) 'Evaluation of Zinc-alpha-2-Glycoprotein and Proteasome Subunit beta-Type 6 Expression in Prostate Cancer Using Tissue Microarray Technology'. Applied Immunohistochemistry, 18 :512-517. [DOI] [Details]
Perry AS, Watson RW, Lawler M, Hollywood D (2010) 'The epigenome as a therapeutic target in prostate cancer'. Nature Reviews Urology, 7 (12):668-680. [DOI] [Details]
Fan, Y.,Murphy, T. B.,Watson, R. W.; (2009) 'digeR: a graphical user interface R package for analyzing 2D-DIGE data'. Bioinformatics, 25 (2222):3033-43033. Available Online [Details]
Daly, P. J., Docherty, N. G., Healy, D. A., McGuire, B. B., Fitzpatrick, J. M., Watson, R. W. (2009) 'The single insult of hypoxic preconditioning induces an antiapoptotic response in human proximal tubular cells, in vitro, across cold storage'. BJU Int, 103 (2):254-9. Available Online [Details]
Watson RW, Maher BM, Dhonnchu TN, Burke JP, Soo A, Wood AE, ; (2009) 'Statins alter neutrophil migration by modulating cellular Rho activity--a potential mechanism for statins-mediated pleotropic effects?'. Journal of Leukocyte Biology, 85 (1):186-193. [DOI] [Details]
Watson RW, Docherty NG, Calvo IF, Quinlan MR, Pérez-Barriocanal F, McGuire BB, Fitzpatrick JM, ; (2009) 'Increased E-cadherin expression in the ligated kidney following unilateral ureteric obstruction'. Kidney International, 2 (NA):205-213. [DOI] [Details]
Watson RW, Walsh S, Gill C, O'Neill A, Fitzpatrick JM, ; (2009) 'Hypoxia increases normal prostate epithelial cell resistance to receptor-mediated apoptosis via AKT activation'. International Journal of Cancer, 124 (8):1871-1878. [DOI] [Details]
McCann A, Watson JA, Watson CJ, McCrohan AM, Woodfine K, Tosetto M, McDaid J, Gallagher E, Betts D, Baugh J, O'Sullivan J, Murrell A, Watson RW, ; (2009) 'Generation of an epigenetic signature by chronic hypoxia in prostate cells'. Human Molecular Genetics, 18 (19):3594-3604. [DOI] [Details]
Watson RW, Fanning DM, Kay E, Fan Y, Fitzpatrick JM, ; (2009) 'Prostate cancer grading: the effect of stratification of needle biopsy Gleason Score 4 + 3 as high or intermediate grade'. BJU International, . [DOI] [Details]
Watson RW, Soo A, Maher B, McCarthy J, Nölke L, Wood A, ; (2009) 'Pre-operative Determination of an Individual's Neutrophil Response: A Potential Predictor of Early Cardiac Transplant Cellular Rejection'. Journal of Heart and Lung Transplantation, . [DOI] [Details]
Watson RW, Fanning DM, Yue F, Fitzpatrick JM, ; (2009) 'Novel predictive tools for Irish radical prostatectomy pathological outcomes: development and validation'. Irish Journal of Medical Science, (NA). [DOI] [Details]
O'Connell PR, Burke JP, Watson RW, Murphy M, Docherty NG, Coffey JC, ; (2009) 'Simvastatin impairs smad-3 phosphorylation and modulates transforming growth factor beta1-mediated activation of intestinal fibroblasts'. British Journal of Surgery, 5 (NA):541-551. [DOI] [Details]
Walsh, S,Gill, C,O'Neill, A,Fitzpatrick, JM,Watson, RWG; (2009) 'Hypoxia increases normal prostate epithelial cell resistance to receptor-mediated apoptosis via AKT activation'. Journal of Cancer, 124 :1871-1878. [DOI] [Details]
Byrne, JC,Downes, MR,O'Donoghue, N,O'Keane, C,O'Neill, A,Fan, Y,Fitzpatrick, JM,Dunn, MJ,Watson, RWG; (2009) '2D-DIGE as a Strategy To Identify Serum Markers for the Progression of Prostate Cancer'. Journal of Proteome Research, 8 :942-957. [DOI] [Details]
Foley, R,Marignol, L,Thomas, AZ,Cullen, IM,Perry, AS,Tewari, P,O'Grady, A,Kay, E,Dunne, B,Loftus, B,Watson, RW,Fitzpatrick, JM,Woodson, K,Lehman, T,Hollywood, D,Lynch, TH,Lawler, M; (2009) 'The HIF-1 alpha C1772T polymorphism may be associated with susceptibility to clinically localised prostate cancer but not with elevated expression of hypoxic biomarkers'. Journal of Cancer, 8 :118-124. [Details]
St John Floyd, M., Jr.,Teahan, S. J.,Fitzpatrick, J. M.,Watson, R. W.; (2009) 'Differential mechanisms of bicalutamide-induced apoptosis in prostate cell lines'. Prostate Cancer Prostatic Dis, 12 (11):25-3325. Available Online [Details]
Gill, C.,Dowling, C.,O'Neill, A. J.,Watson, R. W.; (2009) 'Effects of cIAP-1, cIAP-2 and XIAP triple knockdown on prostate cancer cell susceptibility to apoptosis, cell survival and proliferation'. Mol Cancer, 8 :3939. Available Online [Details]
Quinlan, M. R., Watson, R. W. G., Docherty, N. G., Fitzpatrick, J. M., ; (2008) 'Establishment of an in vitro model of mechanical stretch-induced renal tubular cell apoptosis'. BJU International, 101 :41-41. [Details]
Dowling, C. M., Claffey, J., Cuffe, S., Fichtner, I., Pampillon, C., Sweeney, N. J., Strohfeldt, K., Watson, R. W. G., Tacke, M., ; (2008) 'Antitumor activity of Titanocene Y in xenografted PC3 tumors in mice'. Letters in Drug Design Discovery, 5 (2):141-144. [Details]
Quinlan, M. R., Docherty, N. G., Watson, R. W. G., Fitzpatrick, J. M., ; (2008) 'Exploring mechanisms involved in renal tubular sensing of mechanical stretch following ureteric obstruction'. American Journal of Physiology - Renal Physiology, 295 (1):1-11. [DOI] [Details]
Molloy, E. J., O'Neill, A. J., Grantham-Sloan, J. J., Webb, D. W., Watson, R. W. G., ; (2008) 'Maternal and neonatal lipopolysaccharide and Fas responses are altered by antenatal risk factors for sepsis'. Clinical and Experimental Immunology, 151 (2):244-250. [Details]
Byrne, J. C., Downes, M. R., O'Donoghue, N., Fitzpatrick, J. M., Dunn, M. J., Watson, R. W. G., ; (2008) 'Fasting status as a consideration for human serum collection and preparation prior to depletion and analysis'. Electrophoresis, 29 (14):3055-3059. [DOI] [Details]
Docherty N.G , Fuentes Calvo I, Quinlan M.R, Perez-Barriocanal F, McGuire B.B, Fitzpatrick J.M and Watson R.W.G; (2008) 'Relative Increases in E-cadherin Expression in Ligated Versus Non-Ligated Kidneys Following Unilateral Ureteric Obstruction'. Kidney International, . [Details]
Burke, JP,Ferrante, M,Dejaegher, K,Watson, RWG,Docherty, NG,De Hertogh, G,Vermeire, S,Rutgeerts, P,D'Hoore, A,Penninckx, F,Geboes, K,Van Assche, G,O'Connell, PR; (2008) 'Transcriptomic analysis of intestinal fibrosis-associated gene expression in response to medical therapy in Crohn's disease'. Inflammatory Bowel Diseases, 14 (NA):1197-1204. [DOI] [Details]
Quinlan M.R, Perez-Barriocanal F, Wright E, Dillon-Murphy R, Watson RWG, Fitzpatrick JM and Docherty NG.; (2008) 'Analysis of Urinary and Plasma Electrolytes in a Rat Model of Unilateral Ureteric Obstruction (UUO)'. Open Journal of Urology and Neprology, . [Details]
Docherty N.G , Fuentes Calvo I, Quinlan M.R, Perez-Barriocanal F, McGuire B.B, Fitzpatrick J.M and Watson R.W.G; (2008) 'Increased E-cadherin Expression in the Ligated Kidney Following Unilateral Ureteric Obstruction'. Kidney International, . [Details]
Daly P, Docherty N.G, Healy D.A, Taylor C.T, Fitzpatrick J.M and Watson R.W.G. ; (2008) 'The Single Insult of Hypoxic Preconditioning induces an Anti-apoptotic Response in Human Proximal Tubular Cells, in vitro, Across Cold Storage'. BJU International, . [Details]
Bannon, JH,Fichtner, I,O'Neill, A,Pampillon, C,Sweeney, NJ,Strohfeldt, K,Watson, RW,Tacke, M,Mc Gee, MM; (2007) 'Substituted titanocenes induce caspase-dependent apoptosis in human epidermoid carcinoma cells in vitro and exhibit antitumour activity in vivo'. British Journal of Cancer, 97 :1234-1241. [DOI] [Details]
Perry AS, Loftus B;Moroose R;Lynch TH;Hollywood D;Watson RW;Woodson K;Lawler M (2007) 'In silico mining identifies IGFBP3 as a novel target of methylation in prostate cancer'. British Journal of Cancer, 96 (10):1587-1594. [DOI] [Details]
McGuire, B. B., Watson, R. W., Perez-Barriocanal, F., Fitzpatrick, J. M., Docherty, N. G. (2007) 'Gender differences in the renin-angiotensin and nitric oxide systems: relevance in the normal and diseased kidney'. Kidney Blood Press Res, 30 (2):67-80. Available Online [Details]
Burke, JP; Mulsow, JJ; O'Keane, C; Docherty, NG; Watson, RWG; O'Connell, PR; ; (2007) 'Fibrogenesis in Crohn's disease'. American Journal of Gastroenterology, 102 (2):439-448. [Details]
Watson RW, Molloy EJ, O'Neill AJ, Grantham-Sloan JJ, Sheridan-Pereira M, Fitzpatrick JM, Webb DW, ; (2007) 'Neonatal encephalopathy is associated with altered perinatal systemic neutrophil apoptosis'. American Journal of Perinatology, 9 (NA):525-530. [DOI] [Details]
Hogan, M, Claffey, J, Pampillon, C, Watson, RWG, Tacke, M, ; (2007) 'Synthesis and cytotoxicity studies of new dimethylamino-functionalized and azole-substituted titanocene anticancer drugs'. Organometallics, 26 :2501-2506. [Details]
Watson RW, Downes MR, Byrne JC, Pennington SR, Dunn MJ, Fitzpatrick JM, ; (2007) 'Urinary markers for prostate cancer'. Bju International, 2 (NA):263-268. [DOI] [Details]
Watson RW, Gill C, Walsh SE, Morrissey C, Fitzpatrick JM, ; (2007) 'Resveratrol sensitizes androgen independent prostate cancer cells to death-receptor mediated apoptosis through multiple mechanisms'. Prostate, 15 (NA):1641-1653. [DOI] [Details]
Perrv, A, Loftus, B, Moroose, R, Lynch, T, Hollywood, D, Watson, RWG, Woodson, K, Lawler, M, ; (2007) 'Promoter hypermethylation of IGFBP3 is an early event in prostate carcinogenesis'. EUR UROL SUPPL, 6 :191-191. [Details]
Molloy EJ, O'Neill AJ, Grantham J, Sheridan-Pereira M, Fitzpatrick JM, Webb DW, Watson RWG. ; (2007) 'Maternal and neonatal lipopolysaccharide responses are altered in encephalopathy'. American Journal of Perinatology, . [Details]
Molloy EJ, O'Neill AJ, Grantham J, Sheridan-Pereira M, Fitzpatrick JM, Webb DW, Watson RWG. ; (2007) 'Maternal and Neonatal Lipopolysaccharide and Fas responses are altered by sepsis'. Clinical & Experimental Immunology, . [Details]
Healy DG, Wood AE, O Neill A, McCarthy JF, Fitzpatrick JM, Watson RW. ; (2007) 'Can preoperative modelling of individual neutrophil adhesion responses predict renal morbidity'. European Journal of Cardio-Thoracic Surgery, 31 :1088-1093. [Details]
Healy DG, Watson RW, Fitzpatrick JM, Wood AE.; (2007) 'Differential white cell count relationships with human cardiac allograft rejection'. Transplantation Proceedings, 39 (1):218-222. [Details]
Morrissey C, Brown M, O'sullivan J, Weathered N, Watson RW, Tenniswood M.; (2007) 'Epigallocatechin-3-gallate and bicalutamide cause growth arrest and apoptosis in NRP-152 and NRP-154 prostate epithelial cells'. Journal of Urology, 14 (6):545-551. [Details]
Lebret, T; Watson, RWG; Molinie, V; Poulain, JE; O'Neill, A; Fitzpatrick, JM; Botto, H; ; (2007) 'HSP90 expression: A new predictive factor for BCG response in stage Ta-T1 grade 3 bladder tumours'. European Urology, 51 (1):161-167. [Details]
Mc Guire, B, Docherty, NG, Fitzpatrick, JM, Watson, RWG, ; (2007) 'Acute ureteric obstruction leads to increased expression of collagen XVIII and endostatin spanning fragment neostatin'. EUR UROL SUPPL, 6 :114-114. [Details]
Healy, DA; Daly, PJ; Docherty, NG; Murphy, M; Fitzpatrick, JM; Watson, RWG; ; (2006) 'Heat shock-induced protection of renal proximal tubular epithelial cells from cold storage and rewarming injury'. Journal of the American Society of Nephrology : JASN, 17 (3):805-812. [Details]
Healy DG, Watson RW;O'Keane C;Egan JJ;McCarthy JF;Hurley J;Fitzpatrick J;Wood AE (2006) 'Neutrophil transendothelial migration potential predicts rejection severity in human cardiac transplantation'. European Journal of Cardio-thoracic Surgery, 29 (5):760-766. [DOI] [Details]
Docherty, NG; O'Sullivan, OE; Healy, DA; Fitzpatrick, JM; Watson, RWG; ; (2006) 'Evidence that inhibition of tubular cell apoptosis protects against renal damage and development of fibrosis following ureteric obstruction'. American Journal of Physiology - Renal Physiology, 290 (1):4-13. [Details]
O'Kane, HF; Watson, CJ; Johnston, SR; Petak, I; Watson, RWG; Williamson, KE; ; (2006) 'Targeting death receptors in bladder, prostate and renal cancer'. Urology, 175 (2):432-438. [Details]
Docherty, NG; O'Sullivan, OE; Healy, DA; Murphy, M; O'Neill, AJ; Fitzpatrick, JM; Watson, RWG; ; (2006) 'TGF-beta(1)-induced EMT can occur independently of its proapoptotic effects and is aided by EGF receptor activation'. American Journal of Physiology - Renal Physiology, 290 (5):1202-1212. [Details]
Docherty, NG; McGuire, B; O'Sullivan, OE; Watson, RWG; Fitzpatrick, JM; ; (2006) 'N-cadherin is upregulated in the obstructed rat kidney and during mechanical stretch and TGF-beta 1 induced emt of tubular cell cultures'. Nephrology Dialysis Transplantation, 21 (NA):37-37. [Details]
O'Neill, A; Morrissey, C; Cunningham, K; Taylor, C; Fitzpatrick, JM; Watson, RWG; ; (2006) 'Effects of hypoxia on MnSOD expression and subsequent epigallocatechin gallate induced prostate cancer cell apoptosis'. European Urology, Supplements, 5 (14):797-797. [Details]
Molloy, EJ; O'Neill, AJ; Doyle, BT; Grantham, JJ; Taylor, CT; Sheridan-Pereira, M; Fitzpatrick, JM; Webb, DW; Watson, RWG; ; (2006) 'Effects of heat shock and hypoxia on neonatal neutrophil lipopolysaccharide responses: Altered apoptosis, Toll-like receptor-4 and CD11b expression compared with adults'. Biology of the Neonate, 90 (1):34-39. [Details]
O'Connell PR, Beddy D, Mulsow J, Watson RW, Fitzpatrick JM, ; (2006) 'Expression and regulation of connective tissue growth factor by transforming growth factor beta and tumour necrosis factor alpha in fibroblasts isolated from strictures in patients with Crohn's disease'. British Journal of Surgery, 10 (NA):1290-1296. [DOI] [Details]
McCrohan, AM,Morrissey, C,O'Keane, C,Mulligan, N,Watson, C,Smith, J,Fitzpatrick, JM,Watson, RWG; (2006) 'Effects of the dual 5 alpha-reductase inhibitor dutasteride on apoptosis in primary cultures of prostate cancer epithelial cells and cell lines'. Cancer, 106 (NA):2743-2752. [DOI] [Details]
Watson, RWG, O'Neill, A, Brannigan, AE, Coffey, R, Marshall, JC, Brady, HR, Fitzpatrick, JM, ; (2006) 'Regulation of Fas antibody induced neutrophil apoptosis is both caspase and mitochondrial dependent (vol 453, pg 67, 1999)'. FEBS Letters, 580 (3):996-996. [Details]
Pennington SR, Downes MR, Byrne JC, Dunn MJ, Fitzpatrick JM, Watson RW, ; (2006) 'Application of proteomic strategies to the identification of urinary biomarkers for prostate cancer: a review'. Biomarkers, 5 (NA):406-416. [DOI] [Details]
Watson RW, O'Connor K, Gill C, Tacke M, Rehmann FJ, Strohfeldt K, Sweeney N, Fitzpatrick JM, ; (2006) 'Novel titanocene anti-cancer drugs and their effect on apoptosis and the apoptotic pathway in prostate cancer cells'. Apoptosis, 7 (NA):1205-1214. [DOI] [Details]
Healy D, Watson RWG, O Keane C, O Neill AL, Egan JJ, McCarthy JF, Hurley J, Fitzpatrick JM, Wood AE; (2006) 'Individual variation in early neutrophil infiltration of the allograft influences rejection in human cardiac transplantation'. European Journal of Cardio-Thoracic Surgery, 29 (5):760-766. [Details]
Docherty, N. G.,O'Sullivan, O. E.,Healy, D. A.,Murphy, M.,O'Neill A, J.,Fitzpatrick, J. M.,Watson, R. W.; (2006) 'TGF-beta1-induced EMT can occur independently of its proapoptotic effects and is aided by EGF receptor activation'. Am J Physiol Renal Physiol, 290 (5):F1202-12. [Details]
Molloy EJ, O'Neill AJ, Doyle BT, Grantham J, Taylor Ct, Sheridan-Pereira M, Fitzpatrick JM, Webb DW, Watson RWG. ; (2006) 'Altered lipopolysaccharide-induced neutrophil responses following hypoxia and heatshock in both adults and neonates in vitro'. Biology of the Neonate, 90 (1):34-39. [Details]
Gill, C; Walsh, S; Morrissey, C; Fitzpatrick, JM; Watson, RWG; ; (2006) 'Sensitisation of prostate cancer cells to apoptosis involves altered expression of IAPs and increased caspase activation'. European Urology, Supplements, 5 (14):796-796. [Details]
Quinlan, JF; Watson, RWG; Kelly, G; Kelly, PM; O'Byrne, JM; Fitzpatrick, JM; ; (2006) 'Transforming growth factor-beta (TGF-beta) in acute injuries of the spinal cord'. Journal of Bone and Joint Surgery-British Volume, 88B (3):406-410. [Details]
Byrne, J; Downes, M; O'Donoghue, N; Dunn, MJ; Fitzpatrick, JM; Watson, RWG; Pennington, SR; ; (2006) 'Utilising proteomic platforms for the identification of novel serum markers of prostate cancer'. European Urology, Supplements, 5 (14):789-789. [Details]
Byrne, JC; Brennan, L; Downes, MR; O'Donoghue, N; Fitzpatrick, JM; Dunn, MJ; Watson, RWG; Pennington, SR; ; (2006) 'A combined proteomic and metabolomic analysis of prostate cancer serum samples'. Molecular and Cellular Proteomics, 5 (10):71-71. [Details]
Docherty, NG; Healy, DA; O'Sullivan, OE; Fitzpatrick, JM; Watson, RWG; ; (2005) 'The presence of EGF increases proliferation and reduces apoptosis without exerting an anti-fibrotic action during TGF-beta 1 induced EMT of tubular epithelial cells'. Nephrology Dialysis Transplantation, 20 (NA):205-205. [Details]
Long, RM; Morrissey, C; Hamilton, HJ; Farrell, N; Fitzpatrick, JM; Watson, RWG; ; (2005) 'Prostate epithelial cell differentiation is associated with alterations in apoptotic phenotype'. BJU International, 95 (NA):79-79. [Details]
Long, RM; Morrissey, C; Fitzpatrick, JM; Watson, RWG; ; (2005) 'Prostate epithelial cell differentiation and its relevance to the understanding of prostate cancer therapies'. Clinical Science, 108 (1):1-11. [Details]
Molloy, EJ; O'Neill, AJ; Grantham, JJ; Sheridan-Pereira, M; Fitzpatrick, JM; Webb, DW; Watson, RWG; ; (2005) 'Granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor have differential effects on neonatal and adult neutrophil survival and function'. Pediatric Research, 57 (6):806-812. [Details]
Morrissey, C; O'Neill, A; Spengler, B; Christoffel, V; Fitzpatrick, JM; Watson, RWG; ; (2005) 'Apigenin drives the production of reactive oxygen species and initiates a mitochondrial mediated cell death pathway in prostate epithelial cells'. Prostate, 63 (2):131-142. [Details]
Mulsow, JJW; Watson, RWG; Fitzpatrick, JM; O'Connell, PR; ; (2005) 'Transforming growth factor-beta promotes pro-fibrotic behavior by serosal fibroblasts via PKC and ERK1/2 mitogen activated protein kinase cell signaling'. Annals of Surgery, 242 (6):880-889. [Details]
Daly, PJA; Power, RE; Healy, DA; Hickey, DP; Fitzpatrick, JM; Watson, RWG; ; (2005) 'Delayed graft function: a dilemma in renal transplantation'. BJU International, 96 (4):498-501. [Details]
Watson, RWG; Fitzpatrick, JM; ; (2005) 'Targeting apoptosis in prostate cancer: focus on caspases and inhibitors of apoptosis proteins'. BJU International, 96 (NA):30-34. [Details]
Coffey, RNT,Morrissey, C,Taylor, CT,Fitzpatrick, JM,Watson, RWG; (2005) 'Resistance to caspase-dependent, hypoxia-induced apoptosis is not hypoxia-inducible factor-1 alpha mediated in prostate carcinoma cells'. Journal of Cancer, 103 :1363-1374. [DOI] [Details]
Healy, DG; Watson, RW; O'Neill, AJ; Egan, JJ; McCarthy, JF; Hurley, JP; Fitzpatrick, JM; Wood, AE; ; (2005) 'Cytoimmunological surveillance in human cardiac transplantation with the neutrophil'. British Journal of Surgery, 92 (10):1322-1322. [Details]
Kell, MR, Beddy, D, O'Toole, PJ, Conneely, J, Winter, DC, Watson, W, Fitzpatrick, JM, Kerin, M, ; (2004) 'Systemic T cell interleukin 2 production correlates with disease stage in breast cancer patients'. British Journal of Surgery, 91 (9):1227-1227. [Details]
Power, RE; Doyle, BT; Higgins, D; Brady, HR; Fitzpatrick, JM; Watson, RWG; ; (2004) 'Mechanical deformation induced apoptosis in human proximal renal tubular epithelial cells is caspase dependent'. Urology, 171 (1):457-461. [Details]
Hegarty, P; Watson, RWG; Hegarty, NJ; Coffey, RNT; Fitzpatrick, JM; ; (2004) 'Pressure effects on cellular systems: Is there a link with benign prostatic hyperplasia?'. Urology, 64 (2):195-200. [Details]
McEleny, K; Coffey, R; Morrissey, C; Fitzpatrick, JM; Watson, RWG; ; (2004) 'Caffeic acid phenethyl ester-induced PC-3 cell apoptosis is caspase-dependent and mediated through the loss of inhibitors of apoptosis proteins'. BJU International, 94 (3):402-406. [Details]
Molloy, EJ; O'Neill, AJ; Grantham, JJ; Sheridan-Pereira, M; Fitzpatrick, JM; Webb, DW; Watson, RW; ; (2004) 'Labor induces a maternal inflammatory response syndrome'. American Journal of Obstetrics and Gynecology, 190 (2):448-455. [Details]
Beddy, D, Watson, RWG, Fitzpatrick, JM, O'Connell, PR, ; (2004) 'Increased vascular endothelial growth factor production in fibroblasts isolated from strictures in patients with Crohn's disease'. British Journal of Surgery, 91 (1):72-77. [DOI] [Details]
Morrissey, C,Bektic, J,Spengler, B,Galvin, D,Christoffel, V,Klocker, H,Fitzpatrick, JM,Watson, RWG; (2004) 'Phytoestrogens derived from Belamcanda chinensis have an antiproliferative effect on prostate cancer cells in vitro'. Urology, 172 :2426-2433. [DOI] [Details]
O'Neill, AJ; Doyle, BT; Molloy, E; Watson, C; Phelan, D; Greenan, MC; Fitzpatrick, JM; Watson, RWG; ; (2004) 'Gene expression profile of inflammatory neutrophils: Alterations in the inhibitors of apoptosis proteins during spontaneous and delayed apoptosis'. Shock, 21 (6):512-518. [Details]
Molloy, EJ; O'Neill, A; Grantham, JJ; Sheridan-Pereira, M; Fitzpatrick, JM; Webb, DW; Watson, RW; ; (2004) 'Gender alters neonatal neutrophil survival and lipopolysaccharlde (LPS) responsiveness'. Pediatric Research, 55 (4):398-399. [Details]
Mulsow, J; Watson, RW; Fitzpatrick, JM; O'Connell, R; ; (2004) 'Transforming growth factor-beta mediates increased production of extracellular matrix by intestinal fibroblasts'. British Journal of Surgery, 91 (NA):64-65. [Details]
O'Neill, A; Greenan, MC; Doyle, B; Fitzpatrick, JM; Watson, RWG; ; (2004) 'Gene profiling of in vitro and in vivo models of delayed neutrophil apoptosis: a common pathway?'. Biochemical Society Transactions, 32 (NA):470-473. [Details]
Bates, JJ; Watson, RWG; Glynn, CM; O'Neill, AJ; Fitzpatrick, JM; Buggy, DJ; ; (2004) 'Aspirin preserves neutrophil apoptosis after cardiopulmonary bypass'. Shock, 21 (6):495-499. [Details]
McEleny, K; Coffey, R; Morrissey, C; Williamson, K; Zangemeister-Wittke, U; Fitzpatrick, JM; Watson, RWG; ; (2004) 'An antisense oligonucleotide to cIAP-1 sensitizes prostate cancer cells to Fas and TNF alpha mediated apoptosis'. Prostate, 59 (4):419-425. [Details]
Doyle, BT; O'Neill, AJ; Fitzpatrick, JM; Watson, RWG; ; (2004) 'Differentiation-induced HL-60 cell apoptosis: A mechanism independent of mitochondrial disruption?'. Apoptosis, 9 (3):345-352. [Details]
Galvin, DJ; Watson, RWG; O'Neill, A; Coffey, RNT; Taylor, C; Gillespie, JI; Fitzpatrick, JM; ; (2004) 'Hypoxia inhibits human bladder smooth muscle cell proliferation: A potential mechanism of bladder dysfunction'. Neurourology and Urodynamics, 23 (4):342-348. [Details]
Molloy, EJ; O'Neill, AJ; Grantham, JJ; Sheridan-Pereira, M; Fitzpatrick, JM; Webb, DW; Watson, RWG; ; (2004) 'Labour promotes neonatal neutrophil survival and lipopolysaccharide responsiveness'. PEDIATRIC RESEARCH, 56 (1):99-103. [Details]
Beddy, D, Watson, RWG, Fitzpatrick, JM, O'Connell, PR, ; (2004) 'Increased vascular endothelial growth factor production in fibroblasts isolated from strictures in patients with Crohn's disease - Author's reply'. British Journal of Surgery, 91 (5):646-646. [Details]
Beddy, D. J.,Watson, W. R.,Fitzpatrick, J. M.,O'Connell, P. R.; (2004) 'Critical involvement of stress-activated mitogen-activated protein kinases in the regulation of intracellular adhesion molecule-1 in serosal fibroblasts isolated from patients with Crohn's disease'. J Am Coll Surg, 199 (2):234-42. Available Online [Details]
Kell, MR; Beddy, D; Conneely, J; O'Toole, PJ; Winter, DC; Watson, W; Fitzpatrick, JM; Kerin, MJ; ; (2003) 'T-cell function correlates with oncological status and disease stage in breast cancer'. Breast Cancer Research and Treatment, 82 (NA):114-114. [Details]
B.M. Murphy, A.J. ONeill, C. Adrain, R.W.G. Watson, S.J. Martin.; (2003) 'The apoptosome pathway to caspase activation in primary human neutrophils exhibits dramatically reduced requirements for cytochrome c'. Journal of Experimental Medicine, 197 :625-632. [Details]
T. Lebret, R.W.G. Watson, V. Molinie, A. ONeill, C. Gabriel, J.M. Fitzpatrick, H. Botto; (2003) 'Heat shock proteins HSP27, HSP60, HSP70, HSP90 Expression in bladder cancer'. Journal of Cancer, 98 :970-977. [Details]
N.J. Hegarty, L.S. Young, A.J. ONeill, R.W.G. Watson, J.M. Fitzpatrick; (2003) 'Endothelin in unilateral ureteral obstruction: vascular and cellular effects'. Journal of Clinical Investigation, 104 :171-179. [Details]
Brady HR, Higgins DF, Lappin DW, Kieran NE, Anders HJ, Watson RW, Strutz F, Schlondorff D, Haase VH, Fitzpatrick JM, Godson C, ; (2003) 'DNA oligonucleotide microarray technology identifies fisp-12 among other potential fibrogenic genes following murine unilateral ureteral obstruction (UUO): modulation during epithelial-mesenchymal transition'. Kidney International, 64 (6):2079-2091. [DOI] [Details]
Zierau, O; Morrissey, C; Watson, RWG; Schwab, P; Kolba, S; Metz, P; Vollmer, G; ; (2003) 'Antiandrogenic activity of the phytoestrogens naringenin, 6-(1,1-dimethylallyl)naringenin and 8-prenylnaringenin'. Planta Medica, 69 (9):856-858. [Details]
Morrissey, O; Watson, RWG; ; (2003) 'Phytoestrogens and prostate cancer'. Current Drug Targets, 4 (3):231-241. [Details]
Lebret, T; Watson, RWG; Fitzpatrick, JM; ; (2003) 'Heat shock proteins: Their role in urological tumors'. Urology, 169 (1):338-346. [Details]
Beddy, D, Watson, RWG, Fitzpatrick, JM, O'Connell, PR, ; (2003) 'Increased VEGF production in fibroblasts isolated from patients with Crohn's disease'. British Journal of Surgery, 90 (NA):6-6. [Details]
Beddy, D; Watson, RWG; Fitzpatrick, JM; O'Connell, PR; ; (2003) 'TNF-alpha regulates expression of cyclooxygenase-2 by fibroblasts in Crohn's disease'. British Journal of Surgery, 90 (5):629-629. [Details]
Higgins, DF,Lappin, DWP,Kieran, NE,Anders, HJ,Watson, RWG,Strutz, F,Schlondorff, D,Haase, VH,Fitzpatrick, JM,Godson, C,Brady, HR; (2003) 'DNA oligonucleotide microarray technology identifies fisp-12 among other potential fibrogenic genes following murine unilateral ureteral obstruction (UUO): Modulation during epithelial-mesenchymal transition'. Kidney International, 64 :2079-2091. [Details]
Kell, MR, Sweeney, K, Beddy, D, Connelly, J, Winter, DC, Watson, RGW, Fitzpatrick, JM, Kerin, M, ; (2003) 'Systemic T-cells are primed for a tumour permissive phenotype in breast cancer patients'. British Journal of Surgery, 90 (5):602-603. [Details]
Burke, JG; Watson, RWG; Conhyea, D; McCormack, D; Dowling, FE; Walsh, MG; Fitzpatrick, JM; ; (2003) 'Human nucleus pulposis can respond to a pro-inflammatory stimulus'. Spine, 28 (24):2685-2693. [Details]
Molloy, EJ; O'Neill, AJ; Grantham, JJ; Sheridan-Pereira, M; Fitzpatrick, JM; Webb, DW; Watson, RWG; ; (2003) 'Sex-specific alterations in neutrophil apoptosis: the role of estradiol and progesterone'. BLOOD, 120 (7):2653-2659. [Details]
Healy, DA; Watson, RWG; Newsholme, P; ; (2003) 'Polyunsaturated and monounsaturated fatty acids increase neutral lipid accumulation, caspase activation and apoptosis in a neutrophil-like, differentiated HL-60 cell line'. Clinical Science, 104 (2):171-179. [Details]
Hegarty, NJ; Young, LS; O'Neill, AJ; Watson, RWG; Fitzpatrick, JM; ; (2003) 'Endothelin in unilateral ureteral obstruction: Vascular and cellular effects'. Urology, 169 (2):740-744. [Details]
Shaw, CM; Watson, RWG; Fitzpatrick, JM; Kerin, MJ; ; (2003) 'The impact of extracellular matrix proteins on drug resistance in breast cancer cells'. Breast Cancer Research and Treatment, 82 (NA):88-89. [Details]
Kell, MR; Conneely, J; O'Toole, PJ; Winter, DC; Beddy, D; Watson, W; Fitzpatrick, JM; Kerin, M; ; (2003) 'T-cell function correlates with oncological status in breast cancer'. British Journal of Surgery, 90 (NA):46-46. [Details]
Kell, MR, Conneely, J, O'Toole, PJ, Winter, DC, Beddy, D, Watson, W, Fitzpatrick, JM, Kerin, M, ; (2003) 'T-cell function correlates with oncological status in breast cancer'. British Journal of Surgery, 90 (NA):46-46. [Details]
Healy, DA,Watson, RWG,Newsholme, P; (2002) 'Glucose, but not glutamine, protects against spontaneous and anti-Fas antibody-induced apoptosis in human neutrophils'. Clinical Science, 103 :179-189. [Details]
Doyle, BT; O'Neill, AJ; Newsholme, P; Fitzpatrick, JM; Watson, RW (2002) 'The loss of IAP expression during HL-60 cell differentiation is caspase-independent'. Journal of Leukocyte Biology, 71 (2):247-254. [Details]
Galvin DJ, Watson RW;Gillespie JI;Brady H;Fitzpatrick JM (2002) 'Mechanical stretch regulates cell survival in human bladder smooth muscle cells in vitro'. American Journal of Physiology - Renal Physiology, 283 (6):1-9. [DOI] [Details]
Morrissey C., R.W.G. Watson, J.M. Fitzpatrick.; (2002) 'The effects of phytoestrogens on prostate cancer cells in vitro'. British Journal of Cancer, 86 (4):64. [Details]
Barry T. , R.W.G. Watson, D. OHanlon, M. Kennedy, T.F. Gorey, J.M. Fitzpatrick, M.J. Kerin.; (2002) 'A mechanism of drug resistance in breast cancer implicating COX-2. Will NSAIDs be the answer'. British Journal of Cancer, 86 (4):22. [Details]
Barry T., D. Healy, D. OHanlon, R.W.G. Watson, T.F. Gorey, J.M. Fitzpatrick, M.J. Kerins.; (2002) 'Cox-2 expression modulates tumour invasion'. Journal of the American College of Surgeons, 195 (3):62. [Details]
Beddy D., R.W.G. Watson, J.M. Fitzpatrick, P.R. OConnell; (2002) 'TNF-a and IL-1b regulate fibroblast ICAM-1 expression in Crohn disease through a jun kinase pathway'. Journal of the American College of Surgeons, 195 (3):12. [Details]
Beddy D., R.W.G. Watson, J.M. Fitzpatrick, P.R. OConnell.; (2002) 'TNF-alpha regulates expression of cyclo-oxygenase-2 by fibroblasts in Crohnn disease. (Winner of the William OKeeffe Memorial Prize for best Oral presentation)'. Irish Journal of Medical Science, 171 (4):5. [Details]
Power R.W. , R.W.G. Watson, B.T, Doyle, D. Higgins, H.R. Brady, J.M. Fitzpatrick.; (2002) 'The mechanism of mechanical stretch-induced apoptosis in human proximal renal tubular epithelial cells'. Irish Journal of Medical Science, 171 (2):57. [Details]
OBrian M.F. , R.W.G. Watson, J.M. Fitzpatrick. B. Doyle, A. ONeill, P. Newsholme, J.M. Fitzpatrick, R.W.G. Watson. ; (2002) 'HL-60 cell differentiation and apoptosis is associated with decreased inhibitors of apoptosis proteins expression and increased caspase activity'. Journal of Leukocite Biology, 71 :247-254. [Details]
Hegarty N.J. , R.W.G. Watson, L.S. Young, A.J. ONeill, H.R. Brady, J.M. Fitzpatrick.; (2002) 'Cytoprotective effects of nitrates in a cellular model of hydronephrosis'. Kidney International, 62 :70-77. [Details]
McEleny K. , R.W.G. Watson, A. ONeill, R.N. Coffey, J.M. Fitzpatrick; (2002) 'The Inhibitors of Apoptosis Proteins in Prostate Cancer Cell Lines'. Prostate, 51 :131-140. [Details]
Brannigan A.E. , R.W.G. Watson, D. Beddy, H. Hurley, J.M. Fitzpatrick, P.R. OConnell.; (2002) 'Increased adhesion molecule expression in serosal fibroblasts isolated from patients with Inflammatory Bowel Disease is secondary to inflammation'. Annals of Surgery, 235 :507-511. [Details]
R.W.G. Watson.; (2002) 'Redox Regulation of Neutrophil Apoptosis'. 4 :97-104. [Details]
Coffey R.N.T. , R.W.G. Watson, A.J. O' Neill, K. Mc Eleny, J.M. Fitzpatrick; (2002) 'Androgen resistance to apoptosis in the LNCaP cell line; attributable to altered caspase and Bcl-2 expression'. Prostate, 53 :300-309. [Details]
Galvin D.J., R.W.G. Watson, A.J. ONeill, R.T. Coffey, H. Brady, J.I. Gillespie, J.M. Fitzpatrick.; (2002) 'Mechanical stretch alters human bladder smooth muscle phenotype'. European Urology, 1 (1):131. [Details]
Pfeil K. , E.I. E.I. Eder, G. Bartsch, A. ONeill, R.W.G. Watson, H. Klocker; (2002) 'Differences in the expression of Apoptosis-related proteins in LNCaP and Long-term androgen-ablated LNCaP Prostate cancer cells'. European Urology, (1):54. [Details]
Galvin D.J. , R.W.G. Watson, A.J. ONeill, R.N.T. Coffey, C. Taylor, J.I. Gillespie, J.M. Fitzpatrick. .; (2002) 'Hypoxia inhibits proliferation in human bladder smooth muscle cells'. Irish Journal of Medical Science, 171 (2):47. [Details]
Barry T.L. , R.W.G. Watson, D. OHanlon, T.F. Gorey, J.M. Fitzpatrick, M.J. Kerin.; (2002) 'Intracellular introduction of cyclo-oxygenase antisense oligonucleotide enhances chemotherapy-induced apoptosis and prevents chemoresistance in breast cancer'. Irish Journal of Medical Science, 171 (2):45. [Details]
Kells M.R., J. Connelly, D.C. Winters, D. Beddy, C. Canning, R.W.G. Watson, J.M. Fitzpatrick, M. Kerins.; (2002) 'Systemic T-cells demonstrate a tumour permissive response in breast cancer patients'. Irish Journal of Medical Science, 171 (2):36. [Details]
Hegarty N.J., P.K. Hegarty, P. Cunningham, R.N.T. Coffey, R.W.G. Watson, J.M. Fitzpatrick.; (2002) 'Alpha-adrenergic antagonists may modify disease processes in prostate cancer and benign prostate hyperplasia'. Prostate Cancer and Prostatic Diseases, 5 (1):16. [Details]
McEleny, KR; Watson, RWG; Williamson, K; Coffey, RNT; Fitzpatrick, J; ; (2002) 'A novel tri-specific antisense oligonucleotide(AO) to the inhibitors of apoptosis proteins (LAPS) enhances apoptosis in PC3 prostate cancer cells'. British Journal of Cancer, 86 (NA):66-67. [Details]
Murphy, DG; Fitzpatrick, JM; Watson, RWG; ; (2002) 'Changes in the apoptotic phenotype of prostatic epithelial cells during their differentiation from basal to luminal secretory'. British Journal of Cancer, 86 (NA):81-81. [Details]
Coffey, RNT; Watson, RWG; Taylor, CT; Fitzpatrick, JM; ; (2002) 'Altered sensitivity to hypoxia in prostate cancer cell lines; Hypoxia-induced apoptosis a mitochondrial independent event'. British Journal of Cancer, 86 (NA):101-101. [Details]
Burke, JG; Watson, RWG; McCormack, D; Dowling, FE; Walsh, MG; Fitzpatrick, JM; ; (2002) 'Intervertebral discs which cause low back pain secrete high levels of proinflammatory mediators'. Journal of Bone and Joint Surgery-British Volume, 84B (2):196-201. [Details]
Coffey, RNT; Watson, RWG; O'Neill, AJ; Mc Eleny, K; Fitzpatrick, JM; ; (2002) 'Androgen-mediated resistance to apoptosis'. Prostate, 53 (4):300-309. [Details]
Barry, TL; Watson, RWG; Kennedy, M; Fitzpatrick, JM; Kerin, MJ; ; (2002) 'Expression versus-activity. A mechanism implicating cyclooxygenase-2 in breast cancer drug resistance'. Pathology, 198 (NA):28-28. [Details]
Hegarty, PK; Watson, RWG; Coffey, RNT; Webber, MM; Fitzpatrick, JM; ; (2002) 'Effects of cyclic stretch on prostatic cells in culture'. Urology, 168 (5):2291-2295. [Details]
Higgins, DF; Lappin, DWP; Isaka, Y; Watson, RW; Godson, C; Imai, E; Fitzpatrick, JM; Brady, HR; ; (2002) 'Transcriptomic responses underpinning renal tubulointerstitial fibrosis as identified by DNA oligonucleotide microarray technology'. Journal of the American Society of Nephrology : JASN, 13 (NA):560-560. [Details]
Burke, JG,Watson, RWG,McCormack, D,Dowling, FE,Walsh, MG,Fitzpatrick, JM; (2002) 'Spontaneous production of monocyte chemoattractant protein-1 and interleukin-8 by the human lumbar intervertebral disc'. Spine, 27 :1402-1407. [Details]
Goh J, Baird AW, O'Keane C, Watson RW, Cottell D, Bernasconi G, Petasis NA, Godson C, Brady HR, MacMathuna P (2001) 'Lipoxin A(4) and aspirin-triggered 15-epi-lipoxin A(4) antagonize TNF-alpha-stimulated neutrophil-enterocyte interactions in vitro and attenuate TNF-alpha-induced chemokine release and colonocyte apoptosis in human intestinal mucosa ex vivo'. Journal of Immunology, 167 (5):2772-2780. [Details]
N.J. Hegarty, L.S.Young, C.N. Kirwan, A.J. ONeill, D. Bouchier-Hayes, P. Sweeney, R.W.G. Watson, J.M. Fitzpatrick; (2001) 'Nitric oxide in unilateral obstruction-effect on regional renal blood flow'. Kidney International, 59 :1059-1065. [Details]
McEleny K.R. , R.W.G. Watson, J.M. Fitzpatrick; (2001) 'Defining a Role for the Inhibitors of Apoptosis Proteins in Prostate Cancer'. Prostate Cancer and Prostatic Diseases, 4 :28-32. [Details]
Hegarty P.K. , C. OConnell, R.W.G. Watson, D.C. Cottell, J.M. Fitzpatrick.; (2001) 'Measuring collagen in the prostate by scanning electron mircoscopy'. Urology, 165 :210. [Details]
McEleny K.R. , R.W.G. Watson, R.N.T. Coffey, H.J. Muenchan, J.M. Fitzpatrick.; (2001) 'NF-kB manipulation of cIAP-2 alters apoptosis in LNCaP cells'. Urology, 165 :50. [Details]
Molloy E.J. , A.J. ONeill, M. Sheridan-Pereira, J.M. Fitzpatrick, D.W. Webb, R.W.G. Watson.; (2001) 'Perinatal neutrophil apoptosis: contribution to neonatal bacterial sepsis and maternal neutrophilia'. Irish Journal of Medical Science, 170 (1):34. [Details]
McEleny K.R. , R.W.G. Watson, R.N.T. Coffey, P.K. Hegarty, J.M. Fitzpatrick.; (2001) 'Inhibitors of Apoptosis proteins in prostate cancer cells'. European Urology, 39 (5):92. [Details]
Hegarty P.K. , R.W.G. Watson, K.R. McEleny, R.N.T. Coffey, J.M. Fitzpatrick; (2001) 'The role of tissue pressure in the pathogenesis of benign prostatic hyperplasia'. European Urology, 39 :67. [Details]
Galvin D.J. , R.W.G. Watson, A. ONeill, R.N.T. Coffey, J.I. Gillespie, H. Bardy, J. M. Fitzpatrick.; (2001) 'Mechanical stretch as a mechanism of bladder dysfunction'. Irish Journal of Medical Science, 170 (1):49. [Details]
McLornan L. , R.W.G. Watson, J.M. Fitzpatrick.; (2001) 'Growth factor activation of PI-3kinase/AKT in prostate cancer resistance to apoptosis'. Irish Journal of Medical Science, 170 (1):48. [Details]
Molloy E., A.J. ONeill, J. Grantham, M. Sheridan-Pereira, J.M. Fitzpatrick, D.W. Webb, R.W.G. Watson.; (2001) 'Gender differences and immune function'. Irish Journal of Medical Science, 170 (1):39. [Details]
Beddy D.J. , D.A. McNamara, R.W.G. Watson, J.M. Fitzpatrick, P.R. OConnell. .; (2001) 'Localisation of TNF-alpha and VEGF production in patients with active crohns disease'. Irish Journal of Medical Science, 170 (1):37. [Details]
Barry T. , R.W.G. Watson, D. ODanlon, M. Kennedy, T.F. Gorey, J.M. Fitzpatrick, M.J. Kerin.; (2001) 'The Role of Cox-2 expression in apoptotic resistance in breast cancer'. Irish Journal of Medical Science, 170 (1):15. [Details]
Doyle B.T. , H. Hurley, A.J. ONeill, P. Newsholme, J.M. Fitzpatrick, R.W.G. Watson.; (2001) 'The protective role of HSP on HL-60 cell apoptosis'. Biochemical Society Transactions, 29 (5):110. [Details]
Coffey R.N.T. , R.W.G. Watson, J. M. Fitzpatrick.; (2001) 'Caspases: Mediators of prostate cancer cell apoptosis'. 88 (1):37. [Details]
Hegarty P.K., P. Cunningham, R.W.G. Watson, R.N.T. Coffey, J.M. Fitzpatrick.; (2001) 'Appha-adrenergic antagonists induce apoptosis in benign and malignant prostatic epithelia'. Urology, 165 :215. [Details]
ONeill A.J. , B.T. Doyle, A. Murphy, J.M. Fitzpatrick, R.W.G. Watson.; (2001) 'Gene profile of Inflammatory Neutrophils'. Irish Journal of Medical Science, 170 (1):78. [Details]
Hurley, H; Doyle, BT; O'Neill, AJ; Fitzpatrick, JM; Watson, RWG; ; (2001) 'Heat shock protein expression inhibits etoposide induced apoptosis in HL60 cells'. FASEB Journal, 15 (4):315-315. [Details]
Doyle, BT; O'Neill, AJ; Newsholme, P; Fitzpatrick, JM; Watson, RWG; ; (2001) 'HL-60 cell differentiation and resulting apoptosis is associated with decreased expression of the inhibitors of apoptosis protein'. FASEB Journal, 15 (4):313-313. [Details]
O'Neill, AJ; Doyle, BT; Fitzpatrick, JM; Watson, RWG; ; (2001) 'Inhiitors of apoptosis proteins expressed at a basal level in normal or inflammatory neutrophils'. FASEB Journal, 15 (4):335-335. [Details]
Coffey, RNT; Watson, RWG; Fitzpatrick, JM; ; (2001) 'Signaling for the caspases: Their role in prostate cell apoptosis'. Urology, 165 (1):5-14. [Details]
Kavanagh, EG; Watson, RW; Lederer, JA; Fitzpatrick, JM; O'Connell, PR; ; (2001) 'Activated neutrophils upregulate T-cell responses in patients with acute pancreatitis'. British Journal of Surgery, 88 (5):745-746. [Details]
O'Brien, MF; Watson, RWG; Fitzpatrick, JM; ; (2001) 'Insulin-like growth factor I and prostate cancer'. Urology, 58 (1):1-7. [Details]
Hegarty, N.J., Young, L.S., Bouchier-Hayes, D.M., Sweeney, P., Watson, R.G.W., and Fitzpatrick, J.M.; (2001) 'Regional renal blood flow changes following ureteric obstruction'. 59 :1059-1065. [Details]
Coffey, R. N.,Watson, R. W.,Hegarty, P. K.,Watson, C. L.,Wolohan, L.,Brady, H. R.,O'Keane, C.,Fitzpatrick, J. M.; (2001) 'Priming prostate carcinoma cells for increased apoptosis is associated with up-regulation of the caspases'. Cancer, 92 (9):2297-308. [Details]
Molloy, EJ; O'Neill, AJ; Sheridan-Pereira, M; Fitzpatrick, JM; Webb, DW; Watson, RWG; ; (2001) 'Maternal and neonatal apoptosis at delivery: A mechanism for bacterial susceptibility?'. FASEB Journal, 15 (4):369-369. [Details]
Hurley, H; Doyle, BT; O'Neill, AJ; Fitzpatrick, JM; Watson, RWG; ; (2001) 'Heat shock protein expression inhibits etoposide induced apoptosis in HL60 cells'. FASEB Journal, 15 (4):315-315. [Details]
O'Neill, AJ,Boran, SA,O'Keane, C,Coffey, RNT,Hegarty, NJ,Hegarty, P,Gaffney, EF,Fitzpatrick, JM,Watson, RWG; (2001) 'Caspase 3 expression in benign prostatic hyperplasia and prostate carcinoma'. Prostate, 47 :183-188. [Details]
Watson, RWG,Fitzpatrick, JM; (2000) 'Target sites for manipulating apoptosis in prostate cancer'. BJU International, 85 :38-44. [Details]
O'Neill, AJ; O'Neill, S; Hegarty, NJ; Coffey, RNT; Gibbons, N; Brady, H; Fitzpatrick, JM; Watson, RWG; ; (2000) 'Glutathione depletion-induced neutrophil apoptosis is caspase 3 dependent'. Shock, 14 (6):605-609. [Details]
O'Neill, AJ; Brady, HR; Fitzpatrick, JM; Watson, RWG; ; (2000) 'Neutrophil apoptosis is associated with altered caspase processing'. FASEB Journal, 14 (4):194-194. [Details]
Gibbons, NB; Watson, RWG; Coffey, RNT; Brady, HP; Fitzpatrick, JM; ; (2000) 'Heat-shock proteins inhibit induction of prostate cancer cell apoptosis'. Prostate, 45 (1):58-65. [Details]
Coffey, R. N.,Watson, R. W.,Hegarty, N. J.,O'Neill, A.,Gibbons, N.,Brady, H. R.,Fitzpatrick, J. M.; (2000) 'Thiol-mediated apoptosis in prostate carcinoma cells'. Cancer, 88 (9):2092-104. [Details]
Smith, JD; O'Neill, A; Brady, HR; Fitzpatrick, JM; Watson, RWG; ; (2000) 'Cellular glutathione extrusion is an integral part of neutrophil apoptosis'. FASEB Journal, 14 (4):194-194. [Details]
Brannigan, AE; O'Connell, PR; Hurley, H; O'Neill, A; Brady, HR; Fitzpatrick, JM; Watson, RWG; ; (2000) 'Neutrophil apoptosis is delayed in patients with inflammatory bowel disease'. Shock, 13 (5):361-366. [Details]
O'Neill, S; O'Neill, AJ; Conroy, E; Brady, HR; Fitzpatrick, JM; Watson, RWG; ; (2000) 'Altered caspase expression results in delayed neutrophil apoptosis in acute pancreatitis'. Journal of Leukocyte Biology, 68 (1):15-20. [Details]
Watson, RWG,O'Neill, A,Brannigen, AE,Coffey, R,Marshall, JC,Brady, HR,Fitzpatrick, JM; (1999) 'Regulation of Fas antibody induced neutrophil apoptosis is both caspase and mitochondrial dependent'. FEBS Letters, 453 :67-71. [Details]
O'Neill, AJ; Brady, HR; Fitzpatrick, JM; Watson, RWG; ; (1999) 'Differential role of the mitochondria in neutrophil apoptosis'. FASEB Journal, 13 (5):661-661. [Details]
O'Neill, S; Conroy, E; O'Neill, A; Brady, HR; Fitzpatrick, JM; Watson, RWG; ; (1999) 'Altered caspase expression results in delayed neutrophil apoptosis in acute pancreatitis'. FASEB Journal, 13 (5):661-661. [Details]
Watson, RWG; Coffey, R; O'Neill, A; Fitzpatrick, JM; ; (1999) 'Caspase protease manipulation: a novel approach to apoptotic induction in prostate cancer'. Prostate Cancer and Prostatic Diseases, 2 (NA):34-34. [Details]
O'Neill, AJ; Murtagh, JC; Brady, HR; Fitzpatrick, JM; Watson, RWG; ; (1999) 'Delayed neutrophil apoptosis is associated with altered caspase 3 processing'. Journal of Leukocyte Biology, -1 (NA):25-25. [Details]
Watson, RWG; Rotstein, OD; Parodo, J; Bitar, R; Fitzpatrick, J; Marshall, JC; ; (1998) 'Fas induced neutrophil apoptosis is caspase dependent and regulated by thiols'. FASEB Journal, 12 (5):1045-1045. [Details]
Watson, RWG; Brannigen, AE; Fitzpatrick, JM; ; (1998) 'Fas-induced neutrophil apoptosis is mediated through mitochondrial permeability and caspases'. British Journal of Surgery, 85 (11):1563-1563. [Details]
Watson, R.W.G., Rotstein, O.D., Parodo, J., Bitar, R., and Marshall, J.C.; (1998) 'The Interleukin-1converting enzyme (Caspase-1) inhibits apoptosis of inflammatory neutrophils through activation of interleukin-1'. Journal of Immunology, 161 :957-962. [Details]

Other Journals

Foley, R., Gorman, L., Lundon, D., Sharifi, N., Murphy, K., Tuzova, A., Perry, A., Murphy, T.B. and Watson, R.W. (2015) 'Analysis of pro [-2] PSA: A novel biomarker that significantly improves the detection of prostate cancer' International Journal of Surgery 23 (Supplement 1) :S15-S15. [DOI] [Details]
Foley, R.W., Gorman, L., Sharifi, N., Murphy, K., Moore, H., Tuzova, A.V., Murphy, T.B., Lundon, D.J. and Watson, R.W. (2015) 'Improving multivariable prostate cancer risk assessment using the prostate health index' BJU International 116 (Supplement 2) :31-31. [DOI] [Details]
Foley, R.W., Murphy, K., Lundon, D., Perry, A., Power, R., Durkan, G., O'Brien, F., O'Malley, K., Galvin, D., Murphy, T.B. and Watson, R.W. (2015) 'Prostate volume estimation can significantly improve prostate cancer diagnosis' BJU International 116 (Supplement 2) :20-20. [DOI] [Details]
Foley, R.W., Murphy, K., Lundon, D., Durkan, G., Power, R., Galvin, D., Murphy, T.B. and Watson, R.W. (2015) 'An Irish prostate cancer risk calculator' BJU International 116 (Supplement 2) :18-18. [DOI] [Details]
Foley, R.W., Murphy, K., Galvin, D.J., O'Malley, K.J., Murphy, T.B. and Watson, R.W. (2015) 'The creation and internal validation of a novel risk stratification tool for the early diagnosis of prostate cancer' European Urology Supplements 14 (2) :e19-e19. [DOI] [Details]
Foley, R., Murphy, K., Lundon, D., Power, R., Perry, A., Murphy, T.B., Galvin, D., Watson, R.W. (2015) 'The creation, internal validation and external validation of a novel clinical prediction model for the early diagnosis of prostate cancer' International Journal of Surgery 23 (Supplement 1) :S120-S121. [DOI] [Details]
Breen, K.J., Boyce, S., Boyd Lyons, A., Lundon, D., Fitzpatrick, J.M., Murphy, T.B and Watson, R.W. (2014) 'External validation of the 2007 and 2013 updated Partin tables in a cohort of Irish men' BJU International 114 (Supplement 2) :21-21. [DOI] [Details]
Boyce S., Murphy L., Fitzpatrick J.M., Murphy T.B., Watson R.W.G. (2013) 'Validation of a panel of serum biomarkers to inform surgical intervention for prostate cancer' Journal of Clinical Urology 6 (5) :339-339. [DOI] [Details]
Oon S., Fanning D., Fan Y., Boyce S., Murphy T.B., Fitzpatrick J., Klocker H., Power R., Lynch T. and Watson R.W.G. (2011) 'A preoperative serum biomarker panel to determine between low grade and intermediate to high grade prostate cancer' Irish Journal of Medical Science 180 (8) :S270-S270. [DOI] [Details]
Fanning, D.M., Fan, Y., Murphy, B., Klocker, H., Horninger, W., Fitzpatrick, J.M., Watson, R.W.G.; (2010) 'A profile of prostate cancer in Ireland --- development and internal validation of a novel panel of blood biomarkers' Irish Journal of Medical Science 179 (Suppl. 6) :238-239. [Details]
Watson, W, Byrne, J, ODonogue, N, Dunn, M, Scaife, C, Fitzpatrick, J, Pennington, S, ; (2007) 'The prostate cancer research consortium: A bio-resource for the discovery of tissue and serum markers for prostate cancer' Anticancer Research 27 :1372-1372. [Details]
Molloy, E.J., O'Neill, A.J., Doyle, B.T., Grantham, J.J., Taylor, C.T., Sheridan-Pereira, M., Fitzpatrick, J.M. Watson, R.W.G.; (2006) 'Effects of heat shock and hypoxia on neonatal neutrophil lipopolysaccharide responses: altered apoptosis, toll-like receptor-4 and CD11b expression compared with adults' Biology of the Neonate . [Details]
O'Connor, K., Gill, C., Tacke, M., Rehmann, F.-J. K., Strohfeldt, K., Sweeney, N., Fitzpatrick, J. M., Watson, R. W. G. ; (2006) 'Novel Titanocene Anti-Cancer Drugs and their Effect on Apoptosis and the Apoptotic Pathway in Prostate Cancer Cells' Apoptosis . [Details]

Conference Publications

Foley, R.W., Murphy, K., Galvin, D.J., O'Malley, K.J., Murphy, T.B. and Watson, R.W. (2015) The creation and internal validation of a novel risk stratification tool for the early diagnosis of prostate cancer 30th Annual Congress of the European Association of Urology , pp.e19 [DOI] [Details]
Maher, B. M.,Dhonnchu, T. N.,Burke, J. P.,Soo, A.,Wood, A. E.,Watson, R. W.; (2009) Statins alter neutrophil migration by modulating cellular Rho activity--a potential mechanism for statins Society of Leukocyte Biology , pp.186-93186 Available Online [Details]
O'Connell PR, Burke JP, Watson RW, Murphy M, Docherty NG, Coffey JC, ; (2009) The British journal of surgery Simvastatin impairs smad-3 phosphorylation and modulates transforming growth factor beta1-mediated activation of intestinal fibroblasts , pp.541-551 [DOI] [Details]
Watson RW, Fanning DM, Kay E, Fan Y, Fitzpatrick JM, ; (2009) BJU international Prostate cancer grading: the effect of stratification of needle biopsy Gleason Score 4 + 3 as high or intermediate grade [DOI] [Details]
Dowling, C. M., Cuffe, S., Gill, C., Tacke, M., Fitzpatrick, J. M., Watson, R. W. G., ; (2008) European Urology Supplements Effects of docetaxel and novel titanocene analogues on cell death in prostate cancer following downregulation of Id-1 and the IAPS , pp.276-276 [Details]
D'Arcy, F., Foley, R., Perry, A., Marignol, L., Lawler, M., Gaffney, E., Watson, R. G. W., Fitzpatrick, J. M., Lynch, T. H., ; (2008) European Urology Supplements No evidence of XMRV in irish prostate cancer patients with the R462q mutation , pp.271-271 [Details]
Cuffe, S., Dowling, C., Gill, C., Tacke, M., Fitzpatrick, J. M., Carty, M. P., Watson, R. W. G., ; (2008) Ejc Supplements Novel titanocene analogues induce apoptosis in prostate cancer epithelial cells by initiating a DNA damage response , pp.29-29 [Details]
Cuffe, S., Dowling, C., Gill, C., Tacke, M., Fitzpatrick, J. M., Carty, M. P., Watson, R. W. G., ; (2008) Ejc Supplements Novel titanocene analogues induce apoptosis in prostate cancer epithelial cells by initiating a DNA damage response , pp.29-29 [Details]
Dowling, C. M., Cuffe, S., Gill, C., Tacke, M., Fitzpatrick, J. M., Watson, R. W. G., ; (2008) Effects of docetaxel and novel titanocene analogues on cell death in prostate cancer following downregulation of Id-1 and the IAPS Eurpean Association for Urology , pp.276-276 [Details]
Healy, DG,Wood, AE,O'Neill, A,McCarthy, JF,Fitzpatrick, JM,Watson, RW (2007) EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY Can preoperative modelling of individual neutrophil adhesion responses predict renal morbidity? , pp.1088-1093 [DOI] [Details]
O'Connell PR, Beddy D, Mulsow J, Watson RW, Fitzpatrick JM, ; (2006) The British journal of surgery Expression and regulation of connective tissue growth factor by transforming growth factor beta and tumour necrosis factor alpha in fibroblasts isolated from strictures in patients with Crohn's disease , pp.1290-1296 [DOI] [Details]
O'Neill, A; Morrissey, C; Cunningham, K; Taylor, C; Fitzpatrick, JM; Watson, RWG; ; (2006) Effects of hypoxia on MnSOD expression and subsequent epigallocatechin gallate induced prostate cancer cell apoptosis European Association of Urology , pp.797-797 [Details]
Watson RW, O'Connor K, Gill C, Tacke M, Rehmann FJ, Strohfeldt K, Sweeney N, Fitzpatrick JM, ; (2006) Apoptosis : an international journal on programmed cell death Novel titanocene anti-cancer drugs and their effect on apoptosis and the apoptotic pathway in prostate cancer cells , pp.1205-1214 [DOI] [Details]
Gill, C., Walsh, S., Morrissey, C., Fitzpatrick, J., Watson, R.W.G.; (2006) Resveratrol downregulates cIAP-1 expression and enhances death receptor-medicated apoptosis of prostate cancer cells American Association for Cancer Research Washington, USA, , 01-APR-06 - 05-APR-06 [Details]
Gill, C., Walsh, S., Morrissey, C., Fitzpatrick, J., Watson R.W.G.; (2006) Resveratrol downregulates cIAP-1 expression and enhances death receptor-medicated apoptosis of prostate cancer cells American Association for Cancer Research [Details]
   

Editorial

Watson, RWG; (2003) Gene-chip technology and prostate cancer: The identification of new genes regulating tumour progression. Editorial [DOI] [Details]
             

Workshops

DiFranco, M., O'Hurley, G., Kay, E. W., Watson, R. William G. and Cunningham, P. ; (2008) Automated Gleason Scoring of Prostatic Histopathology Slides Using Multi-channel Co-occurrence Texture Features. Workshops [Details]
 

Abstract

Flynn, L,Sheils, O,O'Leary, JJ,Finn, SP,Watson, W,Loda, M,Mucci, L (2013) miRNA Signatures of Indolent and Aggressive Prostate Cancer. Abstract [Details]
Salley, Y,Gallagher, M,Elbaruni, S,Smyth, P,Spillane, C,Martin, CM,Watson, W,Sheils, OM,O'Leary, JJ (2012) Genome Expression Profiling of Holoclones Derived from Prostate Cancer. Abstract [Details]
Corcoran, C,Rani, S,O'Brien, K,O'Neill, A,Watson, W,Crown, J,O'Driscoll, L (2011) THE USE OF IN VITRO CELL LINE MODELS TO INVESTIGATE DOCETAXEL-RESISTANCE IN PROSTATE CANCER. Abstract [Details]
Kinsella, A,Raza, A,Kennedy, S,Fan, Y,Wood, AE,Watson, RW (2011) The impact of high-dose statin therapy, on transendothelial neutrophil migration and serum cholesterol levels in healthy male volunteers. Abstract [Details]
O'Hare, FM,Watson, W,O'Neill, A,Molloy, E (2010) EARLY PRETERM NEONATAL NEUTROPHIL FUNCTION IN RESPONSE TO ENDOTOXIN. Abstract [Details]
McEllistrem, B,Kennedy, S,Fan, Y,Kinsella, A,Wood, AE,Watson, RW (2010) EXAMINING THE CORRELATION BETWEEN NEUTROPHIL MIGRATORY REGULATORS (CD11b, CD47, CD99) AND POST OPERATIVE COMPLICATIONS OF OPEN HEART SURGERY, IN A PRE-OPERATIVE PATIENT COHORT. Abstract [Details]
Dowling, C,Cuffe, S,Tacke, M,Fitzpatrick, J,Watson, W (2008) Manipulating prostate cancer cell susceptibility to docetaxel and novel titanocene analogues induced apoptosis. Abstract [Details]
Parry, A,Powell, C,Lynch, T,Fitzpatrick, J,O'Malley, K,Gaffney, E,Dunne, B,O'Keane, CS,Hollywood, D,Lawler, M,Watson, W (2007) The first report from the irish prostate cancer research consortium: A profile of PSA and pathological parameters in irish men with prostate cancer. Abstract [Details]
Cullen, I,Foley, R,Woodson, K,Fitzpatrick, J,Lynch, T,Watson, W,Lawler, M (2007) The C1772T single nucleotide polymorphism in the HIF-1A alpha gene is over-represented in the primary prostate cancer population. Abstract [Details]
Byrne, J; Downes, M; O'Donoghue, N; Dunn, MJ; Fitzpatrick, JM; Watson, RWG; Pennington, SR; ; (2006) Utilising proteomic platforms for the identification of novel serum markers of prostate cancer. Abstract [Details]
Healy, DG,Watson, RW,O'Neill, AJ,Egan, JJ,McCarthy, JF,Hurley, JP,Fitzpatrick, JM,Wood, AE (2005) Cytoimmunological surveillance in human cardiac transplantation with the neutrophil. Abstract [Details]
Kell, MR,Beddy, D,O'Toole, PJ,Conneely, J,Winter, DC,Watson, W,Fitzpatrick, JM,Kerin, M (2004) Systemic T cell interleukin 2 production correlates with disease stage in breast cancer patients. Abstract [Details]
Mulsow, J,Watson, RW,Fitzpatrick, JM,O'Connell, R (2004) Transforming growth factor-beta mediates increased production of extracellular matrix by intestinal fibroblasts. Abstract [Details]
Molloy, EJ,O'Neill, A,Grantham, JJ,Sheridan-Pereira, M,Fitzpatrick, JM,Webb, DW,Watson, RW (2004) Gender alters neonatal neutrophil survival and lipopolysaccharlde (LPS) responsiveness. Abstract [Details]
Kell, MR,Beddy, D,Conneely, J,O'Toole, PJ,Winter, DC,Watson, W,Fitzpatrick, JM,Kerin, MJ (2003) T-cell function correlates with oncological status and disease stage in breast cancer. Abstract [Details]
Kell, MR,Conneely, J,O'Toole, PJ,Winter, DC,Beddy, D,Watson, W,Fitzpatrick, JM,Kerin, M (2003) T-cell function correlates with oncological status in breast cancer. Abstract [Details]
Higgins, DF,Lappin, DWP,Isaka, Y,Watson, RW,Godson, C,Imai, E,Fitzpatrick, JM,Brady, HR (2002) Transcriptomic responses underpinning renal tubulointerstitial fibrosis as identified by DNA oligonucleotide microarray technology. Abstract [Details]
Kavanagh, EG,Watson, RW,Lederer, JA,Fitzpatrick, JM,O'Connell, PR (2001) Activated neutrophils upregulate T-cell responses in patients with acute pancreatitis. Abstract [Details]
                                                                                       

Research

Research Interests

My focus of research is in prostate cancer which can be divided into two areas:

1. Biomarker discovery and validation: Using the critical mass and bioresource facilities of the Prostate Cancer Research Consortium (of which I am the lead PI) the group undertake to address clinically relevant questions to identify and validate biomarkers for grade and stage of prostate cancer which will inform appropriate treatment strategies.

2. Understanding the mechanisms of resistances to therapy of advanced disease. We have established models of resistance to androgen ablation therapy and chemoresistance and using genechip and bioinformatice strategies have identified central transcription factors which represent novel sites for therapeutic manipulation which form the bases of your research directions as well as the role of EMT in apoptotic resistance.

As a translational biologist based at the Conway Institute I utilise latest technologies to study the cellular and molecular pathways of prostate cancer. I use this knowledge to address clinically relevant questions via my clinical collaborators as part of the Prostate Cancer Research Consortium and iPROSPECT. These studies have identified novel biomarkers for patient stratification into appropriate treatment groups and targets for therapeutic manipulation which we are validating with our International collaborators as part of the Movember Global Action Plan and ToPCaP.

 

 

Research Projects

Sponsor : Health Research Board (HRB)
Title : Building a risk calculator to inform prostate cancer diagnosis
Start Date / End Date : 09-DEC-16 / 08-DEC-18
Sponsor : Science Foundation Ireland (SFI)
Title : Protein Biomarker Arrays for Personalized Treatment of Prostate Cancer
Start Date / End Date : 01-APR-14 / 01-APR-18
Sponsor : Enterprise Ireland (EI)
Randox Teoranta
Title : Validation and Risk Calculator Integration of Novel Biomarkers for Detection of Prostate Cancer
Start Date / End Date : 19-JAN-17 / 19-JUL-18
Sponsor : Science Foundation Ireland (SFI)
Title : Optimal Management of Gender-Specific Cancers via Efficient Use of Protein Profiling, Digital Pathology and Systems Medicine Tools (OPTi-PREDICT)
Start Date / End Date : 01-SEP-16 / 01-SEP-20
Sponsor : Mater College for Postgraduate Education & Research
Title : A characterisation of mucous gel colonisation of phylogenetic subgroups of sulphate reducing bacteria in the colon of patients with active and inactive ulcerative colitis
Start Date / End Date : 01-APR-06 / 30-JUN-07
Sponsor : Cancer Research Ireland (CRI)
Title : Proteomic analysis of urine from prostate cancer patients: translating the proteome to clinical biomarkers
Start Date / End Date : 01-OCT-06 / 30-SEP-09
Sponsor : Temple Street Children's University Hospital (Fundraising Office)
Title : Posterior capsular opacities in developmental and congenital paediatric cataracts
Start Date / End Date : 01-MAY-06 / 30-JUN-09
Sponsor : Science Foundation Ireland (SFI)
Title : Effects of novel titanocene analogues on DNA stability and subsequent cell death in prostate cancer cells
Start Date / End Date : 01-SEP-06 / 31-JAN-10
Sponsor : Irish Heart Foundation
Medical Research Charities Group
Title : Analysis of neutrophil migratory potential as a predictive marker of human cardiac transplant rejection
Start Date / End Date : 01-OCT-06 / 30-SEP-09
Sponsor : Irish Research Council for Science Engineering and Technology (IRCSET)
Title : Neutrophil expression analysis in human cardiac transplant rejection: detection and pre-emption
Start Date / End Date : 01-OCT-05 / 31-MAR-09
Sponsor : Almac Diagnostics Ltd., N.I.
Title : Prostate Cancer Tissue specific microarray generation
Start Date / End Date : 01-APR-06 / 30-JUN-06
Sponsor : Irish Research Council for Science Engineering and Technology (IRCSET)
Title : The investigation of the genotypes associated with the fibrostenosing phenotype of Crohn's disease
Start Date / End Date : 01-OCT-05 / 30-SEP-06
Sponsor : The Wellcome Trust (WT)
Title : Inhibition of TNFR1- and Fas-triggered Death Signals in Inflammatory Neutrophils: A mechanism for the persistence of the systemic inflammatory response syndrome
Start Date / End Date : 01-MAR-98 / 28-FEB-02
Sponsor : Mater Misericordiae University Hospital
Title : Inhibition of Death Signals in Inflammatory Neutrophils
Start Date / End Date : 01-MAR-98 / 28-FEB-99
Sponsor : Mater Misericordiae University Hospital
Title : Induction of Prostate Cell apoptosis: Role of Caspase Proteases
Start Date / End Date : 31-MAR-98 / 27-FEB-99
Sponsor : Mater Misericordiae University Hospital
Title : The functional activity serosal fibroblasts in patients with Crohn¿s disease
Start Date / End Date : 31-MAR-98 / 27-FEB-99
Sponsor : Mater Misericordiae University Hospital
Title : Investigation of the role of nitric oxide and neutrophil incorporation in the renal blood flow changes associated with ureteric obstruction
Start Date / End Date : 31-MAR-98 / 27-FEB-99
Sponsor : Health Research Board (HRB)
Title : The role of the inhibitors of apoptosis (IAP) family of proteins in delayed neutrophil apoptosis
Start Date / End Date : 01-OCT-99 / 30-SEP-02
Sponsor : Health Research Board (HRB)
Title : Equipment Grant: Cytometer
Start Date / End Date : 01-DEC-99 / 28-FEB-02
Sponsor : Irish Cancer Society (ICS)
Title : Regulation of Caspase Expression in Prostate Cancer
Start Date / End Date : 01-OCT-00 / 30-SEP-01
Sponsor : Health Research Board (HRB)
Title : The role of inflammation in neonatal encephalcopathy
Start Date / End Date : 01-JUL-01 / 30-JUN-03
Sponsor : Health Research Board (HRB)
Title : The role of inhibitors of apoptosis proteins in prostate cancer
Start Date / End Date : 01-JUL-01 / 30-JUN-02
Sponsor : Enterprise Ireland (EI)
Title : Identification of genes contributing to delayed neutrophic apoptosis
Start Date / End Date : 01-JUL-01 / 30-JUN-03
Sponsor : Irish Cancer Society (ICS)
Title : Regulation of T-Lymphocute cell susceptibility to apoptosis via the death inducing signaling complex (DISC) in prostate cancer
Start Date / End Date : 01-OCT-01 / 30-SEP-04
Sponsor : Private Funds
Title : Cytoflor 4000
Start Date / End Date : 01-OCT-01 / 30-SEP-02
Sponsor : British Urological Foundation (BUF)
Title : The effects of diethylmaleate on the treatment strategies of prostate cancer in an in vivo animal model
Start Date / End Date : 01-AUG-03 / 31-JUL-04
Sponsor : British Urological Foundation (BUF)
Title : Characterisation of the altered apoptotic phenotype during basal prostate epithelial cell differentiation into luminal cells
Start Date / End Date : 01-AUG-03 / 30-JUL-04
Sponsor : Mater Misericordiae University Hospital
Title : Altering the anti-apoprotic phenotype of prostate cancer cells by rna interferance
Start Date / End Date : 01-JUL-03 / 30-JUN-06
Sponsor : Cancer Research Ireland (CRI)
Title : Altering the anti-apoptopic phenotype of prostate cancer cells by RNA interface
Start Date / End Date : 01-OCT-03 / 28-FEB-07
Sponsor : Irish Cancer Society (ICS)
Title : Development of New Diagnostic, Prognostic and Therapeutic Agents in Prostate Cancer
Start Date / End Date : 01-OCT-03 / 30-SEP-06
Sponsor : Mater Misericordiae University Hospital
Title : The role of methylation in regulating proapaptatic protein resistance in relation to drug resistance in breast cancer
Start Date / End Date : 01-JAN-04 / 31-DEC-04
Sponsor : Mater Misericordiae University Hospital
Title : Heat shock protein and clinical response to cardiopulmonary bypass
Start Date / End Date : 01-JAN-04 / 31-DEC-04
Sponsor : Mater Misericordiae University Hospital
Title : Can individual variation in neutrophil function predict a cute transplant rejection and postoperative infection
Start Date / End Date : 01-JUL-03 / 30-JUN-05
Sponsor : Mater Misericordiae University Hospital
Title : Stricture Pathogenesis in Crohn's Disease - Dr. Jugen Mulsow
Start Date / End Date : 01-JUN-04 / 30-MAY-05
Sponsor : Health Research Board (HRB)
Title : Flow Cytometry: Applications for Cellular Function and Differentiation
Start Date / End Date : 01-JAN-05 / 30-JUN-05
Sponsor : Mater Misericordiae University Hospital
Title : The identification of the molecular pathways and genetic determinants of Multiple Sclerosis (MS)
Start Date / End Date : 01-JAN-05 / 31-DEC-06
Sponsor : British Urological Foundation (BUF)
Title : Role of Collagen XVIII in renal damage subsequent to unilateral to UUO
Start Date / End Date : 01-JUN-05 / 31-JUL-05
Sponsor : Beaumont Transplant Foundation
Title : Effects of Cold Ishaemia on Gene Expression and Protein Expression in Kidney Transplants
Start Date / End Date : 01-SEP-05 / 31-AUG-06
Sponsor : Glaxo Smith Kline, USA
Title : Evolution of avolve in primary cultures cells
Start Date / End Date : 01-NOV-02 / 31-OCT-03
Sponsor : Irish Cancer Society (ICS)
Title : Prostate cancer biomarker discovery: A programme of the prostate cancer research consortium
Start Date / End Date : 01-JAN-07 / 31-DEC-10
Sponsor : Royal College of Surgeons Ireland (RCSI)
Title : Proteomic analysis of urine from prostate cancer patients: translating the proteome to clinical biomarkers
Start Date / End Date : 01-JUL-07 / 30-JUN-08
Sponsor : Royal College of Surgeons Ireland (RCSI)
University College Dublin (UCD)
Title : Chronic Hypoxia in the regulation of Prostate Cancer Resistance to Apoptosis
Start Date / End Date : 01-JUL-08 / 30-JUN-09
Sponsor : British Urological Foundation (BUF)
Title : Valiidation of Prostatic Secretory Proteins as Biomarkers of Prostate Cancer
Start Date / End Date : 01-JUL-08 / 30-JUN-09
Sponsor : British Urological Foundation (BUF)
Title : Chronic hypoxia in the regulation of prostate cancer resistance to apopotosis
Start Date / End Date : 01-JUL-08 / 30-JUN-10
Sponsor : University College Dublin (UCD)
Title : Proteomics 2009 - "Technological Advances, Discovery and Validation"
Start Date / End Date : 26-MAY-08 / 01-DEC-09
Sponsor : Mater Misericordiae University Hospital
Title : The Identification of Pre-Clinical Neutrophil Markers that will Predict Outcome Following Open Heart Surgery
Start Date / End Date : 01-NOV-08 / 31-OCT-09
Sponsor : Royal College of Surgeons Ireland (RCSI)
Title : The Identification and Initial Validation of Serum and Urine Biomarkers for Biochemical Recurrence in Prostate Cancer Patients
Start Date / End Date : 01-JUL-09 / 30-JUN-11
Sponsor : British Urological Foundation (BUF)
Title : The identification and initial validation of serum and urine biomarkers for biochemical recurrence in prostate cancer patients
Start Date / End Date : 01-JUL-09 / 30-JUN-10
Sponsor : Science Foundation Ireland (SFI)
Title : Molecular therapeutics for cancer: translational research to individualise therapy with targeted agents
Start Date / End Date : 01-SEP-09 / 31-MAR-15
Sponsor : Science Foundation Ireland (SFI)
Title : Molecular therapeutics for cancer: translational research to individualise therapy with targeted agents
Start Date / End Date : 01-OCT-09 / 31-MAR-15
Sponsor : Irish Cancer Society (ICS)
Title : The Identification and Validation of Serum Biomarkers for Biochemical Recurrence in Prostate Cancer
Start Date / End Date : 01-OCT-10 / 30-SEP-13
Sponsor : Mater Misericordiae University Hospital
Title : The effect of statin dosage, on the inflammatory response to cardiac surgery, with specific reference to endpoints in the heart, lung and kidneys
Start Date / End Date : 01-MAY-10 / 31-DEC-10
Sponsor : Mater Misericordiae University Hospital
Title : The effects of statins on pulmonary function post cardiac surgery
Start Date / End Date : 01-SEP-10 / 31-AUG-11
Sponsor : University College Dublin (UCD)
Title : Biomarker Discovery and Validation for Prostate cancer Grade
Start Date / End Date : 01-DEC-10 / 31-DEC-11
Sponsor : Health Research Board (HRB)
Title : Validating a panel of serum biomarkers to inform surgical intervention for prostate cancer
Start Date / End Date : 01-JUN-11 / 30-SEP-14
Sponsor : The Mater Foundation
Title : To investigate the mechanisms of treatment resistance in advanced Prostate Cancer
Start Date / End Date : 01-JAN-12 / 30-JUN-13
Sponsor : Urology Foundation
Title : Mechanisms of Docetaxel resistance in castrate resistant prostate cancer
Start Date / End Date : 01-JUL-12 / 30-JUN-14
Sponsor : Prostate Cancer Foundation (PCF)
Title : Shedding light on stromal-epithelial interactions in prostate carcinogenesis and mortality
Start Date / End Date : 15-OCT-12 / 15-OCT-14
Sponsor : Movember Group Pty Ltd
Title : Integrated Global Serum Biomarker Project
Start Date / End Date : 01-JAN-13 / 30-JUN-15
Sponsor : Irish Cancer Society (ICS)
Title : Building a pipeline for novel therapies in castrate-resistant disease; the SRF paradigm.
Start Date / End Date : 01-DEC-12 / 31-JUL-17
Sponsor : Higher Education Authority (HEA)
Title : PRTLI 5: MMI
Start Date / End Date : 01-MAR-11 / 30-SEP-16
Sponsor : Mater Misericordiae University Hospital
Title : MD Scholarship - Ms Aideen Gough
Start Date / End Date : 01-SEP-14 / 30-SEP-16
Sponsor : Irish Cancer Society (ICS)
Title : Integrating biomarkers for the stratification of patients into insignificant and significant prostate cancer
Start Date / End Date : 01-OCT-11 / 31-MAY-15

Recent Postgraduates

Karen Hanrahan
Elizabeth Comerford 

Current Postgraduate Students

Eszter Vargyas, Doctor of Philosophy (PhD)   -   Thesis Supervisor
Colla Cunneen, Medicine (MD)   -   Thesis Supervisor
Aideen Gough, Medicine (MD)   -   Thesis Supervisor

Collaborators

Internal Collaborators

Professor Brendan Murphy

Professor Liam Gallagher 
 
 

External Collaborators

Professor Helmut Klocker, Department of Urology, Innsbruck Medical University, Austria

Professor Zoran Culig, Department of Urology, Innsbruck Medical University, Austria

Dr Colm Morrissey, Department of Urology, University of Washington, USA