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Researchers at UCD

researcher

Billy Bourke

Associate Professor

School Of Medicine
Our Lady's Hospital
Crumlin
Dublin 12

Tel: 01 4096272
Email: billy.bourke@ucd.ie

Biography

My main laboratory research interest is in infectious diarrhoeal diseases of childhood and my group focuses particularly on Campylobacter jejuni, a major human intestinal pathogen and the most common cause of bacterial gastroenteritis. Together with a group of close collaborators that include Marguerite Clyne, Tadhg O'Croinin and Ulla Knaus at UCD and National Childrens Research Center we have developed an internationally competitive infection biology research programme. We have close collaborative ties with leading national and international scientists in the area of Campylobacter pathogenesis.

We also have an established track record in clinical epidemiology research on digestive diseases of childhood. Together with Marion Rowland, a clinical epidemiologist recognized internationally for her work on the epidemiology of H. pylori, we have a major research interest in the epidemiology of cystic fibrosis-associated liver disease. These studies, funded by grants from the Health Research Board and The National Childrens Resarch Center, have focussed on understanding the population incidence and risk factors for the development of liver disease and its complications among Irish children with cystic fibrosis

Professional

Honours and Awards

Year: 2005.
Title: Editorial Board of World Journal of Gastroenterology

Associations

Association: American Gastroenterology Association, Function/Role: Member
Association: North American Society for Gastroenterology, Hepatology & Nutrition, Function/Role: Member
Association: British Society of Gastroenterology, Hepatology & Nutrition, Function/Role: Member
Association: UCD Academic Centre for Paediatric Research, Function/Role: Director
Association: Health Research Board, Function/Role: Panel member/Reviewer
     

Conference Contributions

Mariño K, Struwe W,; Naughton J; Gough R, Carrington SD, Bourke B, Clyne M; Karlsson N, Rudd PM; (2011) Structural characterization of mucin-type O-glycans from chicken intestinal mucins: role in differential C. jejuni adherence. [Poster Presentation (Refereed)], Glycobiology: Gordon Conference, Lucca (Barga) Italy , 08-MAY-11 - 13-MAY-11.
Naughton JA, Marino K, Gough R, Gallagher M, Carrington SD, Bourke B, ClyneM; (2011) Divergent mechanisms of interaction of Helicobacter pylori and Campylobacter jejuni with mucus and mucins. [Poster Presentation], Workshop on Campylobacter and Helicobacter- like organisms, Vancouver , 28-AUG-11 - 01-SEP-11.
Naughton JA, Gough R, Gallagher ME, Carrington SD, Bourke B, Clyne M; (2011) Probing of purified mammalian mucins demonstrates tropism of campylobacter jeujuni for host specific glycans. [Poster Presentation (Refereed)], Mucins in Health and Disease (11th International Workshop on carcinoma-associated Mucins), Robinson College, Cambridge, UK , 09-JUL-11 - 13-JUL-11.
Naughton JA, Marino K, Gough R, Gallagher ME, Carrington SD, Bourke B, Clyne M; (2011) Divergent mechanisms of interaction of Helicobacter pylori and Campylobacter jejuni with mucus and mucins. [Poster Presentation (Refereed)], 4th Annual GlycoScience Ireland Meeting, Teagasc Food Research Centre, Moorepark, Fermoy, Co Cork, Ireland , 21-OCT-11 - 21-NOV-11.
Stanley, R; Raftery, T; Hurley, M; Sugrue, S; Bryce-Smith, A; Broderick, A; Bourke, B; Hussey, S (2015) The impact of aetiology and age on long term outcomes in Irish children on home parenteral nutrition. [Poster Presentation], Irish Society of Gastroenterology Winter Meeting, Cork , 19-NOV-15 - 20-NOV-15.
Yu, I; O'Neill, E; Stanley, R; Carey, A; Kiernan, S; Hamzawi, M; O'Driscoll, K; Quinn, S; Broderick, A; Bourke, B; Raftery, T; Hussey, S (2015) Aetiological risk factors for developing paediatric inflammatory bowel disease in a prospective cohort. [Oral Presentation], ISG Winter Meeting, Cork , 19-NOV-15 - 20-NOV-15.
O¿ Neill, E; Raftery, T; Broderick, A; Bourke, B; Hussey S (2015) The association between serum vitamin D status and disease activity in paediatric inflammatory bowel disease. [Poster Presentation], ISG WINTER MEETING 2015, Cork , 19-NOV-15 - 20-NOV-15.
O'Neill, E; Raftery, T; Broderick, A; Bourke, B; Hussey, S (2016) The association between serum vitamin D status and disease activity in paediatric inflammatory bowel disease. [Poster Presentation], 11th Congress of ECCO, Amsterdam , 16-MAR-16 - 19-MAR-16.
Yu, I; O'Neill, E; Stanley, R; Carey, A; Kiernan, S; Hamzawi, M; O'Driscoll, K; Quinn, S; Broderick, A; Bourke, B; Hussey, S (2016) Aetiological risk factors for developing paediatric inflammatory bowel disease in a prospective cohort. [Poster Presentation], 11th Congress of ECCO, Amsterdam , 16-MAR-16 - 19-MAR-16.
Fitzpatrick E, Sherlock M, Drumm B, Rowland M.; The incidence of cyclic vomiting syndrome in the pediatric population in Ireland. [Other], Presented to the Neurogastroenterology & Motility 2006 Joint International Meeting, Boston, MA .
Connolly, L; Drummond, J; Daly, L; Plant, B; Linnane, B; McElvaney, NG; McNally, P; Javadpour, S; O'Riordan, S; McCormick, A; Broderick, AM; Blackman, S; Bourke, B; Rowland, M; Liver disease research group (2016) Is there an association between diabetes and cystic fibrosis liver disease. [Oral Presentation], ESPGHAN Monothematic Conference on Cystic Fibrosis Liver Disease, Paris, France , 28-JAN-16 - 29-JAN-16.
Bourke, B; Drummond, J; Gallagher, C; McNally, P; Broderick, A; Greally, P; Slattery, D; Daly, L; McElvaney, NG; O'Laoide, R; Rowland, M (2015) Mortality and disease progression among cystic fibrosis patients with non-specific liver abnormalities. [Oral Presentation], United European Gastroenterology Week, Barcelona , 24-OCT-15 - 27-OCT-15.
Alemka A, Clyne, Bourke B; (2008) The interaction of Campylobacter jejuni with the mucus secreting cell line HT29MTCE12. [Plenary Lecture], Irish Division Society for General Microbiology (SGM), National University of Ireland Galway , 27-MAR-08 - 28-MAR-08.
Alemka A, Clyne, Bourke B; (2008) The interaction of Campylobacter jejuni with the mucus secreting cell line HT29MTCE12. [Plenary Lecture], Irish Society of Gastroenterology (ISG) Spring Meeting, Sligo, Ireland , 24-APR-08 - 25-APR-08.
Corcionivoschi N, Clyne M, Bourke; (2007) Alteration in bacterial capsular polysaccharides following co-culture with human epithelial cells. [Poster Presentation], 14th International Workshop on Campylobacter, Helicobacter and Related Organisms, Rotterdam, Netherlands , 03-SEP-07 - 05-SEP-07.
Corcionivoschi N, Clyne M, Bourke B; (2007) Alteration in bacterial capsular polysaccharides following co-culture with human epithelial cells. [Plenary Lecture], Irish Society of Gastroenterology Winter Meeting, Dublin, Ireland , 29-NOV-07 - 29-NOV-07.
*; (2006) Management of cystic fibrosis associated liver disease in children. [Other], Management of cystic fibrosis associated liver disease in children, Dublin , 23-JUN-06 - 23-JUN-06.
*; (2006) Gastroenterology in children and teenagers. [Invited Lecture], Gastroenterology in children and teenagers, Edinburgh , 07-DEC-06 - 07-DEC-06.

Committees

Committee : Scientific Advisory Committee, Children's Research Centre
Committee : UCD Executive Committee
 

Education

Year 1990 Institution:
Qualification: MRCPI Subject:
Year 1988 Institution: University College Dublin
Qualification: MB, BCh, BAO Subject:
Year 1996 Institution: University College Dublin
Qualification: MD Subject:
Year 1990 Institution: Royal Coll Surgeons in Ireland
Qualification: DCH Subject:
     

Journals Edited

World Journal Of Gastroenterology: Editorial Board member.
 

Publications

Books

Bourke, B. and Fleming, P. and Healy, C. (2011) Crohn Disease and Orofacial Granulomatosis. : Wiley-Blackwell. [DOI] [Details]
Chan, V.L. and Sherman, P.M. and Bourke, B. (2006) Bacterial genomes and infectious diseases. : Humana Press. [DOI] [Details]

Book Chapters

Bourke, B; Hussey, S (2016) 'Chronic infections of the small intestine' In: Shanahan, F; Fitz, JG; Kalloo, AN; Podolsky, DK; Camilleri, M; Wang, TC (eds). Yamada's Textbook of Gastroenterology. New York: Wiley Blackwell. [Details]
Shortt, C; Duggan, G; Bourke, B. (2014) 'The intricate relationship between Campylobacter and mucus' In: Sheppard, SK (eds). Campylobacter ecology and evolution. Norfolk, UK: Caister Academic Press. , pp.89-97 [Details]
Bourke B, Fleming P, Healy C (2011) 'Crohns disease and orofacial granulomatosis' In: Irvine AD, Hoeger PH, Yan AC (eds). Harpers textbook of pediatric dermatology 3rd Edition. New Jersey: Wiley-Blackwell. , pp.157.1-157.5 [Details]
Marion Rowland, Billy Bourke, Brendan Drumm; (2008) 'Helicobacter pylori and Peptic Ulcer Disease' In: Kleinman, Goulet, Mieli-Vergani, Sanderson, Sherman, Shneider (eds). Walker's Pediatric Gastrointestinal Disease 5. Canada: BC Decker Inc. , pp.139-151 [Details]
Rowland M, Bourke B, Drumm B (2008) 'Helicobacter pylori and peptic ulcer disease' In: Walker, WA. Goulet, O. Kleinman, RE. Sherman, PM. Shneider, BL. Sanderson, IR (eds). Pediatric Gastrointestinal Disease Pathophysiology, Diagnosis Management. Hamilton: BC Decker Hamilton. [Details]
Rowland M, Bourke B, Drumm B (2000) 'Gastritis and Peptic Ulcer Disease' In: Walker, WA. Durie, PR. Hamilton, JR. Walker-Smith JA. Watkins JB (eds). Pediatric Gastrointestinal Disease Pathophysiology, Diagnosis Management. St Louis: Mosby. , pp.383-404 [Details]

Edited Books

Voon L Chan, Philip M Sherman, Billy Bourke (Ed.). (2006) Bacterial Genomes and Infectious Diseases. USA: Humana Press Inc. [Details]

Peer Reviewed Journals

Shortt C, Scanlan E, Hilliard A, Cotroneo CE, Bourke B, Ó Cróinín T. (2016) 'DNA Supercoiling Regulates the Motility of Campylobacter jejuni and Is Altered by Growth in the Presence of Chicken Mucus'. mBio, 13 (5):e01227-16-e01227-16. [Details]
Alvarez,LA; Kovacic, L; Rodriguez, J; Gosemann, JH; Kubica, M; Pircalabioru, GG; Friedmacher, F; Cean, A; Ghise, A; Sarandan, MB; Puri, P; Daff, S; Plettner, E; von Kriegsheim, A; Bourke, B; Knaus, UG (2016) 'NADPH oxidase-derived H2O2 subverts pathogen signaling by oxidative phosphotyrosine conversion to PB-DOPA'. Proceedings of the National Academy of Sciences of the United States of America, 113 (37):10406-10411. [DOI] [Details]
Pircalabioru G, Aviello G;Kubica M;Zhdanov A;Paclet MH;Brennan L;Hertzberger R;Papkovsky D;Bourke B;Knaus UG (2016) 'Defensive Mutualism Rescues NADPH Oxidase Inactivation in Gut Infection'. Cell host & microbe, 19 (5):651-663. [DOI] [Details]
Hayes P, Dhillon S;O'Neill K;Thoeni C;Hui KY;Elkadri A;Guo CH;Kovacic L;Aviello G;Alvarez LA;Griffiths AM;Snapper SB;Brant SR;Doroshow JH;Silverberg MS;Peter I;McGovern DP;Cho J;Brumell JH;Uhlig HH;Bourke B;Muise AA;Knaus UG (2015) 'Defects in NADPH Oxidase Genes NOX1 and DUOX2 in Very Early Onset Inflammatory Bowel Disease'. Cellular and molecular gastroenterology and hepatology, 1 (5):489-502. [DOI] [Details]
Bourke B, Hussey S (2015) 'Chronic infections of the small intestine'. Current Opinion in Gastroenterology, 31 (2):104-110. [DOI] [Details]
Casey JP, Slattery S;Cotter M;Monavari AA;Knerr I;Hughes J;Treacy EP;Devaney D;McDermott M;Laffan E;Wong D;Lynch SA;Bourke B;Crushell E (2015) 'Clinical and genetic characterisation of infantile liver failure syndrome type 1, due to recessive mutations in LARS'. Journal of Inherited Metabolic Disease, 38 (6):1085-1092. [DOI] [Details]
Naughton J, Duggan G, Bourke B, Clyne M. (2014) 'Interaction of microbes with mucus and mucin: recent developments'. Gut Microbes, 5 (1):48-52. [DOI] [Details]
Rowland M, Gallagher C;Gallagher CG;Laoide R¿¿;Canny G;Broderick AM;Drummond J;Greally P;Slattery D;Daly L;McElvaney NG;Bourke B (2014) 'Outcome in patients with cystic fibrosis liver disease'. Journal of Cystic Fibrosis, 14 (1):120-126. [DOI] [Details]
Rowland M, Gallagher C, Gallagher CG, Laoide RO, Canny G, Broderick AM, Drummond J, Greally P, Slattery D, Daly L, McElvaney NG, Bourke B (2014) 'Outcome in patients with cystic fibrosis liver disease'. Journal of Cystic Fibrosis, . [Details]
Alvarez LA, Bourke B, Pircalabioru G, Georgiev AY, Knaus UG, Daff S, Corcionivoschi (2013) 'Cj1411c Encodes for a Cytochrome P450 Involved in Campylobacter jejuni 81-176 Pathogenicity'. PLoS ONE, 26 (8):e75534. [Details]
Naughton J, Duggan G, Bourke B, Clyne M (2013) 'Interaction of microbes with mucus and mucins: Recent developments'. Gut, 5 (1). [Details]
Crowley E, Bourke B, Hussey S (2013) 'How to use Helicobacter pylori testing in paediatric practice'. Archives of Disease in Childhood, . [DOI] [Details]
Naughton JA, Mariño K, Dolan B, Reid C, Gough R, Gallagher ME, Kilcoyne M, Gerlach JQ, Joshi L, Rudd P, Carrington S, Bourke B, Clyne M. (2013) 'Divergent mechanisms of interaction of Helicobacter pylori and Campylobacter jejuni with mucus and mucins'. Infection and Immunity, 81 :2838-2850. [Details]
Crowley E, Bourke B, Hussey S (2013) 'How to use Helicobacter pylori testing in paediatric practice'. Archives Of Disease In Childhood-Education And Practice Edition, 98 (1):18-25. [Details]
Alemka A, Corcionivoschi N, Bourke B. (2012) 'Defense and adaptation: The complex inter-relationship between Campylobacter jejuni and mucus'. Frontiers in Cellular and Infection Microbiology, 2 :15. [Details]
Drumm BR, Bourke B;Drummond J;McNicholas F;Quinn S;Broderick A;Taaffe S;Twomey J;Rowland M (2012) 'Cyclical vomiting syndrome in children: a prospective study'. Neurogastroenterology and Motility, 24 (10):922-927. [DOI] [Details]
Casey JP, McGettigan P, Lynam-Lennon N, McDermott M, Regan R, Conroy J, Bourke B, O'Sullivan J, Crushell E, Lynch S, Ennis S (2012) 'Identification of a mutation in LARS as a novel cause of infantile hepatopathy'. Molecular Genetics and Metabolism, 106 (3):351-358. [DOI] [Details]
Hope B, Shahdadpuri R, Dunne C, Broderick AM, Grant T, Hamzawi M, O'Driscoll K, Quinn S, Hussey S, Bourke B (2012) 'Rapid rise in incidence of Irish paediatric inflammatory bowel disease'. Archives of Disease in Childhood, . [DOI] [Details]
Corcionivoschi N, Alvarez LA, Sharp TH, Strengert M, Alemka A, Mantell J, Verkade P, Knaus UG, Bourke B. (2012) 'Mucosal Reactive oxygen species decrease virulence by disrupting Campylobacter jejuni phosphotyrosine signaling'. Cell Host and Microbe, 19 :47-59. [Details]
Hope B, Shahdadpuri R, Dunne C, Broderick AM, Grant T, Hamzawi M, O'Driscoll K, Quinn S, Hussey S, Bourke B (2012) 'Rapid rise in incidence of Irish paediatric inflammatory bowel disease'. Archives of Disease in Childhood, 97 (7):590-594. [Details]
Blackburn C, McDermott M, Bourke B (2012) 'Clinical presentation of and outcome for solitary rectal ulcer syndrome in children'. Journal of Pediatric Gastroenterology and Nutrition, 54 (2):263-265. [Details]
Drumm BR, Bourke B, Drummond J, McNicholas F, Quinn S, Broderick A, Taaffe S, Twomey J, Rowland M (2012) 'Cyclic vomiting syndrome in children:A prospective study'. Neurogastroenterology and Motility, . [Details]
Casey JP, McGettigan P, Lynam-Lennon N, McDermott M, Regan R, Conroy J, Bourke B, Sullivan JO, Crushell E, Lynch S, Ennis S (2012) 'Identification of a mutation in LARS as a novel cause of infantile hepatopathy'. Molecular Genetics and Metabolism, 106 (3):351-358. [Details]
Russell RK, Wilson ML, Loganathan S, Bourke B, Kiparissi F, Mahdi G, Torrente F, Rodrigues A, Davies I, Thomas A, Akobeng AK, Fagbemi A, Hyer W, Spray C, Vaish S, Rogers P, McGrogan P, Heuschkel RB, Ayub N, Fell JM, Afzal NA, Green M, Murphy MS, Rao P, Shah N, Ho GT, Naik S, Wilson DC. ; (2011) 'A British Society of Paediatric Gastroenterology, Hepatology and Nutrition survey of the effectiveness and safety of adalimumab in children with inflammatory bowel disease'. Alimentary Pharmacology & Therapeutics, 33 :946-953. [Details]
Rowland M, Gallagher CG;O'Laoide R;Canny G;Broderick A;Hayes R;Greally P;Slattery D;Daly L;Durie P;Bourke B (2011) 'Outcome in cystic fibrosis liver disease'. American Journal of Gastroenterology, 106 (1):104-109. [DOI] [Details]
Hussey S, Fleming P, Rowland M, Harty S, Chan L, Broderick A, Drumm B, Bourke B (2011) 'Disease outcome for children who present with oral manifestations of Crohn's disease'. European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry, 12 (3):167-169. [Details]
Malik S, Ahmed SF, Wilson ML, Shah N, Loganathan S, NAik S, Bourke B, Thomas A, Akobeng, AK, Fagbemi A, Wilson DC, Russell RK; (2011) 'The effects of Ant-TNF ¿ alpha on growth in children with Crohns disease'. Jornal of Crohns and Colitis, . [Details]
Rowland M, Bourke B. ; (2011) 'Liver disease in cystic fibrosis'. Current Opinion in Pulmonary Medicine, 17 :461-466. [Details]
Hussey S, Fleming P, Rowland M, Harty S, Chan L, Broderick A, Drumm B, Bourke B; (2011) 'Disease outcome for children who present with Crohns disease'. European Archives of Paediatric Dentistry, 12 :169-171. [Details]
Rowland M, Gallagher CG, O'Laoide R, Canny G, Broderick A, Hayes R, Greally P, Slattery D, Daly L, Durie P, Bourke B. ; (2011) 'Outcome in cystic fibrosis liver disease'. American Journal of Gastroenterology, 106 :104-109. [Details]
2. Pawlikowska L, Strautnieks S, Jankowska I, Czubkowski P, Emerick K, Antoniou A, Wanty C, Fischler B, Jacquemin E, Wali S, Blanchard S, Nielsen IM, Bourke B, McQuaid S, Lacaille F, Byrne JA, van Eerde AM, Kolho KL, Klomp L, Houwen R, Bacchetti P, Lobritto S, Hupertz V, McClean P, Mieli-Vergani G, Shneider B, Nemeth A, Sokal E, Freimer NB, Knisely AS, Rosenthal P, Whitington PF, Pawlowska J, Thompson RJ, Bull LN. ; (2010) 'Differences in presentation and progression between severe FIC1 and BSEP deficiencies'. Hepatology, 53 :170-178. [Details]
3. Alemka A, Whelan S, Gough R, Clyne M, Gallagher ME, Carrington SD, Bourke B. ; (2010) 'Purified chicken intestinal mucin attenuates Campylobacter jejuni pathogenicity in vitro'. Journal of Medical Microbiology, 59 :898-903. [Details]
4. Alemka A, Clyne M, Shanahan F, Tompkins T, Corcionivoschi N, Bourke B. ; (2010) 'Probiotic colonisation of mucus-adherent HT29MTXE12 cells attenuates Campylobacter jejuni virulence properties'. Infection and Immunity, 78 :2812-2822. [Details]
Rowland M, Fleming P, Bourke B; (2010) 'Looking in the mouth for Crohn's disease'. Inflammatory bowel diseases, 16 :332-337. [DOI] [Details]
Bartlett JR, Friedman KJ, Ling SC, Pace RG, Bell SC, Bourke B, Castaldo G, Castellani C, Cipolli M, Colombo JL, Debray D, Fernandez A, Lacaille F, Macek M Jr, Rowland M, Salvatore F, Taylor C,J, Wainwright C, Wilschanski M, Zemkova D, Hannah WB, Philips MJ, Corey M, Zielenski J, Dorfman R, Wang Y, Zou F, Silverman LM, Drumm ML, Wright FA, Lange EM, Durie PR, Knowles MR,; (2009) 'Genetic modifiers of liver disease in cystic fibrosis'. JAMA, :1076-1083. [Details]
Corcionivoschi N, Clyne M, Lyons A, Gundogdu O, Wren BW, Dorrell N, Karlyshev AV, Bourke B. ; (2009) 'Campylobacter jejuni cocultured with epithelial cells reduces surface capsular polysaccharide expression'. Infect Immun, 77 (5):1959-1967. [Details]
McDermott M, Hussey S, Bourke B, Broderick A, Phelan E, ; (2008) 'Cryptogenic, multifocal, ulcerous, and stenosing enteritis as a manifestation of enterocolic venopathy'. Journal of Pediatric Gastroenterology and Nutrition, 47 (1):107-109. [DOI] [Details]
Rowland M, Fitzpatrick E, Bourke B, Drumm B, ; (2008) 'The incidence of cyclic vomiting syndrome in children: population-based study'. American Journal of Gastroenterology, 103 (4):991-91. [DOI] [Details]
Rowland M, Fitzpatrick E, Bourke B, Drumm B, ; (2007) 'Outcome for children with cyclical vomiting syndrome'. Archives of Disease in Childhood, 92 (11):1001-1004. [DOI] [Details]
Byrne CM, Clyne M, Bourke B. ; (2007) 'Campylobacter jejuni adhere to and invade chicken intestinal epithelial cells in vitro'. Microbiology, 153 pt. 2 :561-569. [Details]
Croinin, T. O.,McCormack, A.,van Vliet, A. H.,Kusters, J. G.,Bourke, B.; (2007) 'Random mutagenesis to identify novel Helicobacter mustelae virulence factors'. FEMS Immunol Med Microbiol, 50 (2):257-63. [Details]
Bourke B, Broderick A, Bohane T. ; (2006) 'Peutz-Jeghers syndrome and management recommendations'. Clinical Gastroenterology and Hepatology, 12 :1550. [Details]
Hashim, A., Mulchy, G., Bourke, B., Clyne, M.; (2006) 'Interaction of Cryptosporidium hominis and Cryptosporidium parvum with primary human and bovine intestinal cells'. INFECTION AND IMMUNITY, 74 (1):99-107. [Details]
Rowland, M,Daly, L,Vaughan, M,Higgins, A,Bourke, B,Drumm, B; (2006) 'Age-Specific incidence of Helicobacter pylori'. GASTROENTEROLOGY, 130 (NA):65-72. [DOI] [Details]
Rowland M, Broderick A, Bourke B. ; (2006) 'Behavioral and nutritional treatment to improve energy intake and growth in toddlers and preschool-aged children with cystic fibrosis'. Journal of Paediatrics, 118 (1):432-433. [Details]
Finn SM, Rowland M, Lawlor F, Kinsella W, Chan L, Byrne O, O'Mahony O, Bourke B. ; (2006) 'The significance of cutaneous spider naevi in children'. Archives of Disease in Childhood, 91 (7):604-605. [Details]
Harty S, Fleming P, Rowland M, Crushell E, McDermott M, Drumm B, Bourke B. ; (2005) 'A prospective study of the oral manifestations of Crohns disease'. Clinical Gastroenterology and Hepatology, 3 :886-891. [Details]
Rowland M, Bourke B, Drumm B. ; (2005) 'Do the Rome criteria help the doctor or the patient?'. Journal of Pediatric Gastroenterology and Nutrition, 41 (Supp 1):S32-S33. [Details]
Bourke B. ; (2005) 'Will treatment of Helicobacter pylori infection in childhood alter the risk of developing gastric cancer?'. Canadian Journal of Gastroenterology, 19 (7):409-411. [Details]
Bourke B, Ceponis P, Chiba N, Czinn S, Ferraro R, Fischbach L, Gold B,Hyunh H, Jacobson K, Jones NL, Koletzko S, Lebel S, Moayyedi P, Ridell R,Sherman P, van Zanten S, Beck I, Best L, Boland M, Bursey F, Chaun H, Cooper G,Craig B, Creuzenet C, Critch J, Govender K, Hassall E, Kaplan A, Keelan M, Noad G, Robertson M, Smith L, Stein M, Taylor D, Walters T, Persaud R, Whitaker S,Woodland; Canadian Helicobacter Study Group. ; (2005) 'Canadian Helicobacter Study Group Consensus Conference: Update on the approach to Helicobacter pylori infection in children and adolescents--an evidence-based evaluation'. Canadian Journal of Gastroenterology, 19 (7):399-408. [Details]
Bourke B, Corbett K, Kelleher S, Rowland M, Daly L, Drumm B, Canny G, Greally P, Hayes R, ; (2004) 'Cystic fibrosis-associated liver disease: a population-based study'. Pediatrics, 3 (NA):327-332. [DOI] [Details]
Crushell E, Hartey S, Sharif F, Bourke B.; (2004) 'Enteric Campylobacter - Purging its secrets?'. Paediatric Research, (55):3-12. [Details]
Hashim A, Clyne M, Mulcahy G, D Akiyoshi, R Chalmers, Bourke B. ; (2004) 'Host cell tropism underlies species restriction of human and bovine Cryptosporidium parvum genotypes'. Infection and Immunity, 72 :6125-6131. [Details]
Bourke B, Crushell E, Harty S, Sharif F, ; (2004) 'Enteric campylobacter: purging its secrets?'. Pediatric Research, 55 (1):3-12. [DOI] [Details]
Mooney A, Byrne C, Clyne M, Johnson-Henry K, Sherman P, Bourke B; (2003) 'Invasion of human epithelial cells by Campylobacter upsaliensis'. Cellular Microbiology, 5 :835-847. [Details]
Crushell E, Rowland M, Doherty M, Gormally S, Harty S, Bourke B, Drumm B. ; (2003) 'Importance of parental conceptual model of illness in severe recurrent abdominal pain'. Journal of Paediatrics, (112):1368-1372. [Details]
Bourke B, ; (2002) 'Campylobacter infection: small bowel and colon'. Current Opinion in Gastroenterology, 18 (1):4-9. [Details]
Sharif F, McDermott M, Dillon M, Rowland M, Kelleher S, Drumm B, Bourke B. ; (2002) 'Focally enhanced gastritis in Crohn disease and ulcerative colitis'. American Journal of Gastroenterology, 97 :1415-1420. [Details]
Drumm B, Bourke B, ; (2002) 'Cochrane's epitaph for cisapride in childhood gastro-oesophageal reflux'. Archives of Disease in Childhood, 86 (2):71-72. [Details]
Jones NL, Bourke B, ; (2001) 'Pathogenesis of Helicobacter pylori infection'. Current Opinion in Gastroenterology, 17 (1):24-29. [Details]
Byrne C, Doherty D, MooneyM, Byrne M, Woodward D, Johnson W, Rogers F, Bourke B. ; (2001) 'Basis of the superiority of cefoperazone amphotericin teicoplainin (CAT) for isolating Campylobacter upsaliensisfrom stools?'. Journal of Clinical Microbiology, (39):2713-2716. [Details]
Mooney A, Clyne M, Curran T, Doherty D, Kilmartin B, Bourke B. ; (2001) 'Campylobacter upsaliensis exerts cytolethal distending toxin effect on HeLa cells and T lymphocytes'. Microbiology, (47):735-743. [Details]
Pittock S, Drumm B, Fleming P, McDermott M, Imrie I, Flint, S, Bourke B. ; (2001) 'The oral cavity in Crohn disease'. J Pediatr, (138):767-771. [Details]
Drumm B, Imrie C, Rowland M, Bourke B, ; (2001) 'Is Helicobacter pylori infection in childhood a risk factor for gastric cancer?'. Pediatrics, 107 (2):373-380. [Details]
Bourke B, Mooney A, Clyne M, Curran T, Doherty D, Kilmartin B, ; (2001) 'Campylobacter upsaliensis exerts a cytolethal distending toxin effect on HeLa cells and T lymphocytes'. Journal of Microbiology, 147 (Pt 3):735-743. [Details]
Bourke B, Pittock S, Drumm B, Fleming P, McDermott M, Imrie C, Flint S, ; (2001) 'The oral cavity in Crohn's disease'. Pediatrics, 138 (5):767-771. [DOI] [Details]
Bourke B, Sharif F, Crushell E, O'Driscoll K, ; (2001) 'Liquid paraffin: a reappraisal of its role in the treatment of constipation'. Archives of Disease in Childhood, 85 (2):121-124. [Details]
Sherman PM, Bourke B, ; (1999) 'Gastrointestinal infections in children'. Current Opinion in Gastroenterology, 15 (1):79-84. [Details]
Drumm B, Rowland M, Imrie C, Bourke B, ; (1999) 'How should Helicobacter pylori infected children be managed?'. Gut, 45 Suppl 1 (NA):1-9. [Details]
Sherman P, Bourke B, Chan VL, ; (1998) 'Campylobacter upsaliensis: waiting in the wings'. Clinical Microbiology Reviews, 11 (3):440-449. [Details]
Drumm B, Bourke B, Goggin N, Walsh D, Kennedy S, Setchell KD, ; (1996) 'Byler-like familial cholestasis in an extended kindred'. Archives of Disease in Childhood, 75 (3):223-227. [Details]
Drumm B, Bourke B, Sherman P, ; (1994) 'Peptic ulcer disease: what is the role for Helicobacter pylori?'. Seminars in Gastrointestinal Disease, 5 (1):24-31. [Details]
       

Editorial

Kutty J, Hussey S;Broderick AM;Quinn S;Bourke B (2015) HLA testing for coeliac disease in Ireland?. Editorial [Details]
                                                                                   

Research

Research Interests

Diarrhoeal disease is one of the main causes of mortality in children worldwide. I am interested in understanding how infectious pathogens, in particular Campylobacter jejuni, causes diarrhoea. Specifically my group has been focused on developing better understanding of the mechanisms of infection by using sophisticated in vitro models as well as directly examining intestinal tissue ex vivo. Together with Prof Ulla Knaus and supported by the National Childrens Research Center our group has uncovered a novel role for epithelial NADPH-oxidases in protecting the host mucosal surface from bacterial infection. We also have been studying the interaction of enteric microorganisms with mucus (in conjunction with Dr M. Clyne (UCD SoM, and Alimentary Glycosciences Research Cluster) and the role of DNA supercoiling in bacterial behaviour (with  Dr T O'Croinin SBBS).

My clinical research interests include, in particular, cystic fibrosis associated liver disease and inflammatory bowel disease. Together with Dr Marian Rowland we have identified and characterised children throughout Ireland with CFLD. By gathering information on all the children and adolescents within Ireland with this condition we have the opportunity to understand what its impact is on patients with this condition. In conjunction with colleagues at the Irish Tertiary Gastroenterology Dept in Our Lady's Hospital (S Hussey/ AM Broderick) I care for Irish children with Crohn's disease and ulcerative colitis. We have seen a striking increase in the incidence of these conditions across the past decade in this country and have set up a major research study with help from the Children's Medical and Research Foundation to help better understand this development and to help engage with international efforts to treat this these conditions.

UCD Medicine Research Centre: Paediatric Diseases

FUNDING AGENCIES:
Health Research Board
Children's Medical & Research Foundation
Science Foundation Ireland

Research Projects

Sponsor : Health Research Board (HRB)
Title : Epidemiology and Natural History of Eosinophilic Oesophagitis in Ireland - A paediatric perspective
Start Date / End Date : 06-JUN-16 / 31-JUL-16
Sponsor : Health Research Board (HRB)
Title : The Natural History of Cystic Fibrosis Liver Disease- Refining the Phenotype
Start Date / End Date : 06-OCT-14 / 04-JAN-18
Sponsor : Health Research Board (HRB)
Title : The Role of Carbohydrates in Mediating Adherence and Invasion of Campylobacter Jejuni to Intestinal Cells
Start Date / End Date : 08-JUN-10 / 03-AUG-10
Sponsor : University College Dublin (UCD)
Title : The interaction of pathogenic organism with mucosal surfaces and epithelial cells
Start Date / End Date : 26-MAY-08 / 01-DEC-09
Sponsor : University College Dublin (UCD)
Title : Investigation of the role played by DNA supercoiling in the regulation of virulence genes of C. jejuni
Start Date / End Date : 26-MAY-08 / 01-DEC-09
Sponsor : Enterprise Ireland (EI)
Title : cDNA Representational difference analysis to explore temperature regulated gene transcription in the food-borne pathogen campylobacter
Start Date / End Date : 01-OCT-01 / 30-SEP-03
Sponsor : Science Foundation Ireland (SFI)
Title : The role and regulation of bacterial capsular polysaccharide in the pathogenesis of Campylobacter infection
Start Date / End Date : 01-NOV-05 / 28-FEB-10
 

Current Postgraduate Students

Lucy Connolly, Doctor of Philosophy (PhD)   -   Thesis Supervisor
Eileen Crowley, Medicine (MD)   -   Thesis Supervisor

Collaborators

Internal Collaborators


Professor Ulla Knaus
Dr Marguerite Clyne  
Dr Marion Rowland  
Dr Tadhg O'Croinin
Dr Jennifer Drummond
Dr Luis Alvarez
Dr Letal Salzberg