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Researchers at UCD

Brendan Drumm

Professor of Paediatrics

School Of Medicine
Health Sciences Centre
Belfield
Dublin 4

Tel:
Email: brendan.drumm@ucd.ie

Biography

Professor Drumm, undertook his medical studies at University College Galway and graduated in 1979.

 

In 1981 he started his postgraduate clinical training at the Hospital for Sick Children in Toronto where he was subsequently appointed Consultant Paediatric Gastroenterologist and Assistant Professor of Pediatrics at the University of Toronto.

 

In 1990 he was appointed Professor and Head of the Department of Paediatrics at University College Dublin and Consultant Paediatric Gastroenterologist at Our Lady's Children¿s Hospital in Dublin, where he established a paediatric Gastroenterology research unit. This research unit,which includes Dr Marguerite Clyne, Prof Billy Bourke and Dr Marion Rowland is recognised internationally as a leader in research in  gastrointestinal diseases in childhood.

 

Professor Drumm has over 100 research reports, book chapters and reviews published.  The ranking of his research internationally is confirmed by publications on several occasions in prestigious journals such as the New England Journal of Medicine, The Lancet, Gastroenterology, The Journal of Clinical Investigation and the Proceedings of the National Academy of Sciences.

 

His research has been supported by grants from agencies varying from the Wellcome Trust in the UK, to the European Union, American Gastroenterology Association, Irish Health Research Board, Medical Research Council of Canada and the Children¿s Research Foundation.

 

Professor Drumm has been an invited speaker for National Colleges of Physicians and National Gastroenterology associations across the world including the United States, England, Canada, Scotland, Holland and Australia, and has been a guest speaker at Universities in over 20 countries.

 

In 2005 the Irish Government appointed Professor Drumm as the first CEO of the Health Service Executive (HSE) in Ireland  for a five year term.

 

The HSE was established to unify and manage the health and personal social care services in Ireland. Before 2005 services were provided through a series of unconnected agencies and health boards.

 

The HSE employs 110,000 people and has an annual budget of approximately 15 billon euro.

 

As CEO, Professor Drumm led the largest public service Transformation Programme ever undertaken in Ireland.

 

This Programme concentrated on building an integrated healthcare service that delivers the vast majority of care to patients and clients in their own homes or as close to their home as possible.

 

The major building blocks included:

 

A major hospital reconfiguration programme.

 

A national network of comprehensive Primary Care Teams.

 

Developing clinical leadership focused on improving access, quality and value at national, regional and local level.

 

Developing a comprehensive performance management system

 

Value for money and cost containment initiatives that enabled cost reductions of over 1 billion euros and significant service level increases across all areas.

 

!n 2011 he returned to University College Dublin. He is developing programmes focused on promoting clinicians as leaders of change in the provision of health care internationally. He has a particular interest in changing the provision of health services to try and ensure that care and healing are as important as investigating, treating and curing patients.

 

He is a Fellow of the Royal Colleges of Physicians in Canada, Ireland and the UK, and was in the first group of Gastroenterologists awarded with a fellowship of the American Gastroenterology Association in 2008 in recognition of his contribution to research in gastrointestinal disease.

 

For more information about Professor Brendan Drumm see brendandrumm.com

Publications

 

Book Chapters

Rowland M, Bourke B, Drumm B (2008) 'Helicobacter pylori and peptic ulcer disease' In: Walker, WA. Goulet, O. Kleinman, RE. Sherman, PM. Shneider, BL. Sanderson, IR (eds). Pediatric Gastrointestinal Disease Pathophysiology, Diagnosis Management. Hamilton: BC Decker Hamilton. [Details]
Rowland M, Bourke B, Drumm B (2000) 'Gastritis and Peptic Ulcer Disease' In: Walker, WA. Durie, PR. Hamilton, JR. Walker-Smith JA. Watkins JB (eds). Pediatric Gastrointestinal Disease Pathophysiology, Diagnosis Management. St Louis: Mosby. , pp.383-404 [Details]
Rowland M, Drumm B (1996) 'Helicobacter pylori infection in children In Helicobcater pylori' In: Hunt, RH Tytgat, GNJ (eds). Basic Mechanisms to Clinical Cure. Dordrecht: Kluwer Academic Publications. , pp.286-294 [Details]
 

Peer Reviewed Journals

Brett, T,Rowland, M,Drumm, B (2012) 'An approach to functional abdominal pain in children and adolescents'. British Journal of General Practice, 62 :386-387. [DOI] [Details]
Drumm BR, Bourke B;Drummond J;McNicholas F;Quinn S;Broderick A;Taaffe S;Twomey J;Rowland M (2012) 'Cyclical vomiting syndrome in children: a prospective study'. Neurogastroenterology and Motility, 24 (10):922-927. [DOI] [Details]
Drumm B, Rowland M; (2011) 'Why is Helicobacter pylori disappearing? More questions than answers'. Jornal de Pediatria, 87 (5):369-370. [DOI] [Details]
Hussey S, Fleming P, Rowland M, Harty S, Chan L, Broderick A, Drumm B, Bourke B (2011) 'Disease outcome for children who present with oral manifestations of Crohn's disease'. European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry, 12 (3):167-169. [Details]
Rowland M, Fitzpatrick E, Bourke B, Drumm B, ; (2008) 'The incidence of cyclic vomiting syndrome in children: population-based study'. American Journal of Gastroenterology, 103 (4):991-91. [DOI] [Details]
Reeves, EP,Ali, T,Leonard, P,Hearty, S,O'Kennedy, R,May, FEB,Westley, BR,Josenhans, C,Rust, M,Suerbaum, S,Smith, A,Drumm, B,Clyne, M; (2008) 'Helicobacter pylori Lipopolysaccharide Interacts With TFF1 in a pH-Dependent Manner'. Journal of Gastroenterology, 135 :2043-2054. [DOI] [Details]
Rowland M, Fitzpatrick E, Bourke B, Drumm B, ; (2007) 'Outcome for children with cyclical vomiting syndrome'. Archives of Disease in Childhood, 92 (11):1001-1004. [DOI] [Details]
Oderda, G; Shcherbakov, P; Bontems, P; Urruzuno, P; Romano, C; Gottrand, F; Gomez, MJM; Ravelli, A; Gandullia, P; Roma, E; Cadranel, S; De Giacomo, C; Canani, RB; Rutigliano, V; Pehlivanoglu, E; Kalach, N; Roggero, P; Celinska-Cedro, D; Drumm, B; Casswall, T; Ashorn, M; Arvanitakis, SN; PERTH Grp; ; (2007) 'Results from the Pediatric European Register for Treatment of Helicobacter pylori (PERTH)'. Helicobacter, 12 (2):150-156. [Details]
Dolan, B., Drumm, B., Clyne, M., ; (2007) 'The interaction of Helicobacter pylori with a mucous secreting cell line'. Zoonoses and Public Health, 54 :95-95. [Details]
Reeves, E. P., Leonard, P., Hearty, S., O'Kennedy, R., May, F. E. B., Westley, B. R., Drumm, B., Clyne, M., ; (2007) 'Rough-form lipopolysaccharide of Helicobacter pylori promotes adhesion to trefoil protein TFF1 - a pH regulated interaction'. Zoonoses and Public Health, 54 :8-8. [Details]
Murphy, A. M.,Drumm, B.,Brenner, C.,Lynch, S. A.; (2006) 'Diencephalic cachexia of infancy: Russell's syndrome'. Clin Dysmorphol, 15 (4):253-4. [Details]
Rowland, M,Daly, L,Vaughan, M,Higgins, A,Bourke, B,Drumm, B; (2006) 'Age-Specific incidence of Helicobacter pylori'. GASTROENTEROLOGY, 130 (NA):65-72. [DOI] [Details]
Rowland M, Bourke B, Drumm B. ; (2005) 'Do the Rome criteria help the doctor or the patient?'. Journal of Pediatric Gastroenterology and Nutrition, 41 (Supp 1):S32-S33. [Details]
Rowland, M; Bourke, B; Drumm, B; ; (2005) 'Functional abdominal pain - Do the Rome criteria help the doctor or the patient?'. Journal of Pediatric Gastroenterology and Nutrition, 41 (NA):32-33. [Details]
Harty S, Fleming P, Rowland M, Crushell E, McDermott M, Drumm B, Bourke B. ; (2005) 'A prospective study of the oral manifestations of Crohns disease'. Clinical Gastroenterology and Hepatology, 3 :886-891. [Details]
Corbett K, Kelleher S, Rowland M, Daly L, Drumm B, Canny G, Greally P, Hayes R, Bourke B.; (2004) 'Cystic fibrosis-associated liver disease: A population-based study'. Journal of Paediatrics, 145 :327-332. [Details]
Howes, N,Lerch, MM,Greenhalf, W,Stocken, DD,Ellis, I,Simon, P,Truninger, K,Ammann, R,Cavallini, G,Charnley, RM,Uomo, G,Delhaye, M,Spicak, J,Drumm, B,Jansen, J,Mountford, R,Whitcomb, DC,Neoptolemos, JP (2004) 'Clinical and Genetic Characteristics of Hereditary Pancreatitis in Europe'. Clinical Gastroenterology and Hepatology, 2 :252-261. [DOI] [Details]
Clyne, M; Drumm, B; ; (2004) 'Helicobacter pylori infection of human and murine primary gastric cells'. Infection and Immunity, 72 (9):5464-5469. [Details]
Clyne M, Dillon P, Daly S, O'Kennedy R, May FE, Westley BR, Drumm B.; (2004) 'Helicobacter pylori interacts with the human single-domain trefoil protein TFF1'. Proceedings of the National Academy of Sciences of the, 101 (19):7409-7414. [Details]
Crushell, E,Rowland, M,Doherty, M,Gormally, S,Harty, S,Bourke, B,Drumm, B; (2003) 'Importance of parental conceptual model of illness in severe recurrent abdominal pain'. Pediatrics, 112 :1368-1372. [Details]
Drumm B, Bourke B, ; (2002) 'Cochrane's epitaph for cisapride in childhood gastro-oesophageal reflux'. Archives of Disease in Childhood, 86 (2):71-72. [Details]
Sharif, F; McDermott, M; Dillon, M; Drumm, B; Rowland, M; Imrie, C; Kelleher, S; Harty, S; Bourke, B; ; (2002) 'Focally enhanced gastritis in children with Crohn's disease and ulcerative colitis'. American Journal of Gastroenterology, 97 (6):1415-1420. [Details]
Drumm B, Imrie C, Rowland M, Bourke B, ; (2001) 'Is Helicobacter pylori infection in childhood a risk factor for gastric cancer?'. Pediatrics, 107 (2):373-380. [Details]
Rowland, M; Drumm, B; ; (2001) 'Helicobacter pylori and sudden-infant-death syndrome'. Lancet, 357 (9253):327-327. [Details]
Oderda, G; Cadranel, S; Drumm, B; Koletzko, S; ; (2001) 'Announcing the creation of the Paediatric European Register for Treatment of Helicobacter pylori (PERTH)'. Journal of Pediatric Gastroenterology and Nutrition, 33 (5):526-527. [Details]
Howes, N,Greenhalf, W,Rutherford, S,O'Donnell, M,Mountford, R,Ellis, I,Whitcomb, D,Imrie, C,Drumm, B,Neoptolemos, JP; (2001) 'A new polymorphism for the R122H mutation in hereditary pancreatitis'. Gut, 48 :247-250. [Details]
Imrie, C,Rowland, M,Bourke, B,Drumm, B; (2001) 'Limitations to carbon 13-labeled urea breath testing for Helicobacter pylori in infants'. Pediatrics, 139 :734-737. [Details]
Pittock S, Drumm B, Fleming P, McDermott M, Imrie I, Flint, S, Bourke B. ; (2001) 'The oral cavity in Crohn disease'. J Pediatr, (138):767-771. [Details]
OCroinin, T., Clyne, M., Appelmelk, B. J., and Drumm, B.; (2001) 'Antigastric autoantibodies in ferrets naturally infected with Helicobacter mustelae'. Infection and Immunity, 69 :2708-2713. [Details]
Clyne M, Ocroinin T, Suerbaum S, Josenhans C, Drumm B. ; (2000) 'Adherence of isogenic flagellum-negative mutants of Helicobacter pylori and Helicobacter mustelae to human and ferret gastric epithelial cells'. Infection and Immunity, 68 (7):4335. [Details]
Bourke, B; Drumm, B; ; (2000) 'The efficacy of cisapride; Time to review not regurgitate'. Journal of Pediatric Gastroenterology and Nutrition, 30 (3):230-230. [Details]
OCroinin, T; Clyne, R; Drumm, B; ; (2000) 'Helicobacter mustelae infection of the ferret as a natural animal model for Helicobacter adherence studies'. Gut, 47 (NA):4-4. [Details]
Croinin, TO; Heerma, SB; Drumm, B; Vandenbroucke-Grauls, CMJ; Bourke, B; Kusters, JG; ; (2000) 'Identification of Helicobacter mustelae virulence factors by screening of a random insertional mutant library'. Gut, 47 (NA):62-63. [Details]
Clyne, M, OCroinin, T, Drumm, B, ; (2000) 'Adherence mechanism of Helicobacter pylori and Helicobacter mustelae to primary human and ferret gastric cells'. Gut, 47 (NA):1-1. [Details]
Clyne M, O Croinin T, Drumm B, Moran A, Hynes S, Henegan M.; (1999) 'Mimicry of Blood group Antigen A by Helicobacter mustelae and Helicobacter pylori'. GASTROENTEROLOGY, 116 (2). [Details]
Vaughan, D; Drumm, B; ; (1999) 'Treatment of fistulas with granulocyte colony-stimulating factor in a patient with Crohn's disease'. New England Journal of Medicine, 340 (3):239-240. [Details]
Drumm B, Rowland M, Imrie C, Bourke B, ; (1999) 'How should Helicobacter pylori infected children be managed?'. Gut, 45 Suppl 1 (NA):1-9. [Details]
Vaughan, D; Imrie, C; Kelleher, J; Drumm, B; Osborne, H; ; (1999) 'Pancreatic duct stenting as a treatment for hereditary pancreatitis'. Pediatrics, 104 (5):1129-1133. [Details]
Rowland, M,Kumar, D,Daly, L,O'Connor, P,Vaughan, D,Drumm, B; (1999) 'Low rates of Helicobacter pylori reinfection in children'. Journal of Gastroenterology, 117 :336-341. [Details]
Bull, LN; Juijn, JA; Liao, M; van Eijk, MJT; Sinke, RJ; Stricker, NL; DeYoung, JA; Carlton, VEH; Baharloo, S; Klomp, LWJ; Abukawa, D; Barton, DE; Bass, NM; Bourke, B; Drumm, B; Jankowska, I; Lovisetto, P; McQuaid, S; Pawlowska, J; Tazawa, Y; Villa, E; Tygstrup, N; Berger, R; Knisely, AS; Houwen, RHJ; Freimer, NB; ; (1999) 'Fine-resolution mapping by haplotype evaluation: the examples of PFIC1 and BRIC'. Journal of Human Genetics, 104 (3):241-248. [Details]
Bull, LN,Juijn, JA,Liao, M,van Eijk, MJT,Sinke, RJ,Stricker, NL,DeYoung, JA,Carlton, VEH,Baharloo, S,Klomp, LWJ,Abukawa, D,Barton, DE,Bass, NM,Bourke, B,Drumm, B,Jankowska, I,Lovisetto, P,McQuaid, S,Pawlowska, J,Tazawa, Y,Villa, E,Tygstrup, N,Berger, R,Knisely, AS,Houwen, RHJ,Freimer, NB; (1999) 'Fine-resolution mapping by haplotype evaluation: the examples of PFIC1 and BRIC'. Gene, 104 :241-248. [Details]
Goggin, N; Rowland, N; Imrie, C; Walsh, D; Clyne, M; Drumm, B; ; (1998) 'Effect of Helicobacter pylori eradication on the natural history of duodenal ulcer disease'. Archives of Disease in Childhood, 79 (6):502-505. [Details]
Dillon, M,Brown, S,Casey, W,Walsh, D,Durnin, M,Abubaker, K,Drumm, B; (1998) 'Colonoscopy under general anesthesia in children'. Pediatrics, 102 :381-383. [Details]
Rowland, M,Drumm, B; (1998) 'Clinical significance of Helicobacter infection in children'. British Medical Bulletin, 54 :95-103. [Details]
Rowland M, Lambert I, Gormally S, Daly LE, Thomas JE, Hetherington C, Durnin M, Drumm B. ; (1998) 'C-13 urea breath test for the diagnosis of Helicobacter pylori in children'. GUT, 43 (NA):8-8. [Details]
Clyne, M, Drumm, B, ; (1998) 'No correlation between H-pylori and blood groups in gastric cancer - Reply'. Journal of Gastroenterology, 114 (3):621-621. [Details]
Croinin, TO; Clyne, M; Drumm, B; ; (1998) 'Molecular mimicry of ferret gastric epithelial blood group antigen a by Helicobacter mustelae'. Journal of Gastroenterology, 114 (4):690-696. [Details]
Clyne, M, Covacci, A, Drumm, B, Crabtree, JE, ; (1997) 'Adherence of Helicobacter pylori to gastric epithelial cells and induction of interleukin-8'. Gut, 41 (NA):110-110. [Details]
Rowland, M; Kumar, D; OConnor, P; Daly, LE; Drumm, B; ; (1997) 'Reinfection with Helicobacter pylori in children'. Journal of Gastroenterology, 112 (4):273-273. [Details]
Clyne, M; Covacci, A; Drumm, B; Crabtree, JE; ; (1997) 'Adherence of Helicobacter pylori to gastric epithelial cells and induction of interleukin-8'. Gut, 41 (NA):110-110. [Details]
Rowland, M; Kumar, D; OConnor, P; Daly, LE; Drumm, B; ; (1997) 'Reinfection with Helicobacter pylori in children'. Gut, 41 (NA):1-1. [Details]
Walsh, D; Drumm, B; ; (1997) 'Helicobacter pylori: challenges for the paediatrician'. Paediatrics and Child Health, 33 (6):469-470. [Details]
Rowland, M,Lambert, I,Gormally, S,Daly, LE,Thomas, JE,Hetherington, C,Durnin, M,Drumm, B; (1997) 'Carbon 13 - Labeled urea breath test for the diagnosis of Helicobacter pylori infection in children'. Pediatrics, 131 :815-820. [Details]
Clyne, M,Drumm, B; (1997) 'Absence of effect of Lewis a and Lewis B expression on adherence of Helicobacter pylori to human gastric cells'. Journal of Gastroenterology, 113 :72-80. [Details]
Clyne M, Thomas J, Weaver L, Drumm B.; (1997) 'In vitro evaluation of the role of antibodies against Helicobacter pylori in inhibiting adherence of the organism to gastric cells'. Gut, 40 (6):731-738. [Details]
OCroinin, T; Clyne, M; Drumm, B; ; (1997) 'Helicobacter mustelae specific antibodies cross react with ferret gastric tissue'. Journal of Gastroenterology, 112 (4):1054-1054. [Details]
Clyne, M,Drumm, B; (1996) 'The urease enzyme of Helicobacter pylori does not function as an adhesin'. Infection and Immunity, 64 :2817-2820. [Details]
Clyne, M; Drumm, B; ; (1996) 'Cell envelope characteristics of Helicobacter pylori: Their role in adherence to mucosal surfaces and virulence'. FEMS Immunology and Medical Microbiology, 16 (2):141-155. [Details]
Drumm B, Bourke B, Goggin N, Walsh D, Kennedy S, Setchell KD, ; (1996) 'Byler-like familial cholestasis in an extended kindred'. Archives of Disease in Childhood, 75 (3):223-227. [Details]
Gormally, SM, Kierce, BM, Daly, LE, Bourke, B, Carroll, R, Durnin, MT, Drumm, B, ; (1996) 'Gastric metaplasia and duodenal ulcer disease in children infected by Helicobacter pylori'. Gut, 38 (4):513-517. [Details]
GORMALLY, SM; PRAKASH, N; DURNIN, MT; DALY, LE; CLYNE, M; KIERCE, BM; DRUMM, B; ; (1995) 'ASSOCIATION OF SYMPTOMS WITH HELICOBACTER-PYLORI INFECTION IN CHILDREN'. Pediatrics, 126 (5):753-756. [Details]
CLYNE, M; LABIGNE, A; DRUMM, B; ; (1995) 'HELICOBACTER-PYLORI REQUIRES AN ACIDIC ENVIRONMENT TO SURVIVE IN THE PRESENCE OF UREA'. Infection and Immunity, 63 (5):1669-1673. [Details]
EISENSTAT, DDR; GRIFFITHS, AM; CUTZ, E; PETRIC, M; DRUMM, B; ; (1995) 'ACUTE CYTOMEGALOVIRUS-INFECTION IN A CHILD WITH MENETRIERS DISEASE'. Journal of Gastroenterology, 109 (2):592-595. [Details]
CLYNE, M; DRUMM, B; ; (1995) 'THE UREASE ENZYME OF HELICOBACTER-PYLORI DOES NOT FUNCTION AS AN ADHESIN'. Journal of Gastroenterology, 108 (4):798-798. [Details]
CLYNE, M; THOMAS, J; DRUMM, B; ; (1995) 'EFFECT OF BREAST-MILK AND SPECIFIC ANTIBODIES ON ADHERENCE OF HELICOBACTER-PYLORI'. Journal of Gastroenterology, 108 (4):798-798. [Details]
ABUBAKAR, K; GOGGIN, N; GORMALLY, S; DURNIN, M; DRUMM, B; ; (1995) 'PREPARING THE BOWEL FOR COLONOSCOPY'. Archives of Disease in Childhood, 73 (5):459-461. [Details]
CLYNE, M, DRUMM, B, ; (1994) 'HELICOBACTER-PYLORI REQUIRES AN ACIDIC ENVIRONMENT TO SURVIVE IN THE PRESENCE OF UREA'. Journal of Gastroenterology, 106 (4):666-666. [Details]
GORMALLY, SM; BAKER, A; PORTMANN, B; MOWAT, A; DRUMM, B; ; (1994) 'HIGH WATER COPPER CONTENT ASSOCIATED WITH INDIAN CHILDHOOD CIRRHOSIS IN EUROPEAN CHILDREN'. Journal of Gastroenterology, 106 (4):900-900. [Details]
Drumm B, Bourke B, Sherman P, ; (1994) 'Peptic ulcer disease: what is the role for Helicobacter pylori?'. Seminars in Gastrointestinal Disease, 5 (1):24-31. [Details]
SHABIB, SM,CUTZ, E,DRUMM, B,SHERMAN, PM; (1994) 'ASSOCIATION OF GASTRIC METAPLASIA AND DUODENITIS WITH HELICOBACTER-PYLORI INFECTION IN CHILDREN'. J Clin Pathol, 102 :188-191. [Details]
GORMALLY, SM; PRAKASH, N; DURNIN, M; DALY, L; KIERCE, B; DRUMM, B; ; (1994) 'SYMPTOMS IN CHILDREN BEFORE AND AFTER TREATMENT OF HELICOBACTER-PYLORI INFECTION'. Journal of Gastroenterology, 106 (4):83-83. [Details]
CLYNE, M, DRUMM, B, ; (1993) 'CHARACTERIZATION OF BINDING OF HELICOBACTER-PYLORI TO A GASTRIC ADENOCARCINOMA CELL-LINE'. Journal of Gastroenterology, 104 (4):57-57. [Details]
CLYNE, M, DRUMM, B, ; (1993) 'ADHERENCE OF HELICOBACTER-PYLORI TO PRIMARY HUMAN GASTROINTESTINAL CELLS'. Journal of Gastroenterology, 104 (4):56-56. [Details]
LAMBERT, I, CLYNE, M, DRUMM, B, ; (1993) 'HELICOBACTER-PYLORI IN DENTAL PLAQUES'. Lancet, 341 (8850):957-957. [Details]
CLYNE, M, DRUMM, B, ; (1993) 'ADHERENCE OF HELICOBACTER-PYLORI TO PRIMARY HUMAN GASTROINTESTINAL CELLS'. Infection and Immunity, 61 (10):4051-4057. [Details]
DRUMM, B; (1993) 'HELICOBACTER-PYLORI IN THE PEDIATRIC-PATIENT'. Journal of Gastroenterology, 22 :169-182. [Details]
Drumm, B., Perez-Perez, G., Blaser, M., and Sherman, P.; (1990) 'Intrafamilial clustering of Helicobacter pylori0 infection'. Then New England Journal of Medicine, 312 :359-363. [Details]
Drumm, B., Sherman, P., Cutz, E., and Karmali, M.; (1987) 'Association of Campylobacter pylori0 on the Gastric Mucosa with Antral Gastritis in Children'. 316 :1557-1561. [Details]
Sharif, F., McDermott, M., Dillon, M., Rowland, M., Kelleher, S., Drumm, B., and Bourke, B.; (0) 'Focally enhanced gastritis in Crohn disease and ulcerative colitis'. American Journal of Gastroenterology, . [Details]

Other Journals

Harty, S., Fleming, P., Rowland, M., Crushell, E., McDermott, M., Drumm, B., Bourke, B.; (2005) 'A prospective study of the oral manifestations of Crohn's disease' Clin Gastroenterol Hepatol . [Details]
Harty, S., Fleming, P., Rowland, M., Crushell, E., McDermott, M., Drumm, B., Bourke, B.; (2005) 'A prospective stidy of the oral manifestations of Crohn's disease' Clin Gastroenterol Hepatol . [Details]

Conference Publications

Smith, A., Clyne, M., Carrington, S.D., Drumm, B., and Reid, C.; (2007) Construction and expression of a truncated version of MUC5AC as a model system to investigate its role in pathogen'mucosal interactions Mucins in Health and Disease (9th International Workshop on Carcinoma-associated Mucins) Robinson College Cambridge July 2007 [Details]
Rowland, M,Bourke, B,Drumm, B (2005) JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION Functional abdominal pain - Do the Rome criteria help the doctor or the patient? , pp.32-33 [Details]
Rowland, M,Imrie, C,Bourke, B,Drumm, B (1999) GUT How should Helicobacter pylori infected children be managed? , pp.36-39 [Details]
O Croinin T, Clyne M, Appelmelk B, Claeys D and Drumm B; (1999) Presence of anti-gastric atuoantibodies in ferrets naturally infected with Helicobacter mustelae American Society of Microbiology : Annual General Meeting [Details]
Clyne M, O Croinin T and Drumm B; (1999) Adherence of Helicobacter pylori and Helicobacter mustelae to gastric cells studied using confocal microscopy American Society of Microbiology : Annual General Meeting [Details]
Goggin, N,Rowland, N,Imrie, C,Walsh, D,Clyne, M,Drumm, B (1998) ARCHIVES OF DISEASE IN CHILDHOOD Effect of Helicobacter pylori eradication on the natural history of duodenal ulcer disease , pp.502-505 [Details]
O Croinin T, Clyne M and Drumm B; (1997) Helicobacter mustelae specific antibodies cross-react with ferret gastric tissue Second European Meeting on Pathogenesis and Host Response in Helicobacter pylori infections [Details]
O Croinin T, Clyne M and Drumm B; (1997) Molecular mimicry of ferret gastric epithelial blood group antigen A by Helicobacter mustelae American Gastroenterology Association : Annual General Meeting [Details]
Clyne, M,Drumm, B (1996) FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY Cell envelope characteristics of Helicobacter pylori: Their role in adherence to mucosal surfaces and virulence , pp.141-155 [Details]
   

Editorial

Drumm, B,Rowland, M; (2003) The epidemiology of Helicobacter pylori: Where to from here?. Editorial [Details]
Drumm, B; (2001) The dangers of consensus. Editorial [Details]
Rowland, M,Drumm, B; (2001) Helicobacter pylori and sudden-infant-death syndrome. Editorial [Details]
Oderda, G,Cadranel, S,Drumm, B,Koletzko, S; (2001) Announcing the creation of the Paediatric European Register for Treatment of Helicobacter pylori (PERTH). Editorial [Details]
                 

Abstract

Drumm, B,Bourke, B,McNicholas, F,Broderick, A,Quinn, S,Drummond, J,Rowland, M (2011) CYCLICAL VOMITING SYNDROME, A PROSPECTIVE STUDY. Abstract [Details]
Reeves, EP,Leonard, P,Hearty, S,O'Kennedy, R,May, FEB,Westley, BR,Drumm, B,Clyne, M (2007) Rough-form lipopolysaccharide of Helicobacter pylori promotes adhesion to trefoil protein TFF1 - a pH regulated interaction. Abstract [Details]
Dolan, B,Drumm, B,Clyne, M (2007) The interaction of Helicobacter pylori with a mucous secreting cell line. Abstract [Details]
Clyne, M,OCroinin, T,Drumm, B (2000) Adherence mechanism of Helicobacter pylori and Helicobacter mustelae to primary human and ferret gastric cells. Abstract [Details]
OCroinin, T,Clyne, R,Drumm, B (2000) Helicobacter mustelae infection of the ferret as a natural animal model for Helicobacter adherence studies. Abstract [Details]
Croinin, TO,Heerma, SB,Drumm, B,Vandenbroucke-Grauls, CMJ,Bourke, B,Kusters, JG (2000) Identification of Helicobacter mustelae virulence factors by screening of a random insertional mutant library. Abstract [Details]
Rowland, M,Lambert, I,Gormally, S,Daly, LE,Thomas, JE,Hetherington, C,Durnin, M,Drumm, B (1998) C-13 urea breath test for the diagnosis of Helicobacter pylori in children. Abstract [Details]
Rowland, M,Kumar, D,OConnor, P,Daly, LE,Drumm, B (1997) Reinfection with Helicobacter pylori in children. Abstract [Details]
Clyne, M,Covacci, A,Drumm, B,Crabtree, JE (1997) Adherence of Helicobacter pylori to gastric epithelial cells and induction of interleukin-8. Abstract [Details]
OCroinin, T,Clyne, M,Drumm, B (1997) Helicobacter mustelae specific antibodies cross react with ferret gastric tissue. Abstract [Details]
CLYNE, M,THOMAS, J,DRUMM, B (1995) EFFECT OF BREAST-MILK AND SPECIFIC ANTIBODIES ON ADHERENCE OF HELICOBACTER-PYLORI. Abstract [Details]
GORMALLY, SM,PRAKASH, N,DURNIN, MT,DALY, LE,CLYNE, M,KIERCE, BM,DRUMM, B (1995) ASSOCIATION OF SYMPTOMS WITH HELICOBACTER-PYLORI INFECTION IN CHILDREN. Abstract [Details]
EISENSTAT, DDR,GRIFFITHS, AM,CUTZ, E,PETRIC, M,DRUMM, B (1995) ACUTE CYTOMEGALOVIRUS-INFECTION IN A CHILD WITH MENETRIERS DISEASE. Abstract [Details]
CLYNE, M,DRUMM, B (1995) THE UREASE ENZYME OF HELICOBACTER-PYLORI DOES NOT FUNCTION AS AN ADHESIN. Abstract [Details]
GORMALLY, SM,PRAKASH, N,DURNIN, M,DALY, L,KIERCE, B,DRUMM, B (1994) SYMPTOMS IN CHILDREN BEFORE AND AFTER TREATMENT OF HELICOBACTER-PYLORI INFECTION. Abstract [Details]
CLYNE, M,DRUMM, B (1994) HELICOBACTER-PYLORI REQUIRES AN ACIDIC ENVIRONMENT TO SURVIVE IN THE PRESENCE OF UREA. Abstract [Details]
GORMALLY, SM,BAKER, A,PORTMANN, B,MOWAT, A,DRUMM, B (1994) HIGH WATER COPPER CONTENT ASSOCIATED WITH INDIAN CHILDHOOD CIRRHOSIS IN EUROPEAN CHILDREN. Abstract [Details]
GORMALLY, S,DRUMM, B (1994) HELICOBACTER-PYLORI AND GASTROINTESTINAL SYMPTOMS. Abstract [Details]
CLYNE, M,DRUMM, B (1993) CHARACTERIZATION OF BINDING OF HELICOBACTER-PYLORI TO A GASTRIC ADENOCARCINOMA CELL-LINE. Abstract [Details]
CLYNE, M,DRUMM, B (1993) ADHERENCE OF HELICOBACTER-PYLORI TO PRIMARY HUMAN GASTROINTESTINAL CELLS. Abstract [Details]
GORMALLY, SM,KIERSE, B,BOURKE, B,DURNIN, M,CARROLL, R,DRUMM, B (1993) GASTRIC METAPLASIA AND DUODENAL-ULCER DISEASE IN CHILDREN. Abstract [Details]
       

Reviews

Imrie, C,Rowland, M,Bourke, B,Drumm, B (2001) Is Helicobacter pylori infection in childhood a risk factor for gastric cancer?. Reviews [Details]
DRUMM, B (1990) HELICOBACTER-PYLORI. Reviews [Details]
                                                   

Letters

Drumm, B,Vaughan, D (2003) Granulocyte-macrophage colony-stimulating factor for Crohn's disease. Letters [Details]
Clyne, M,O Croinin, T,Drumm, B (1999) Mimicry of blood group antigen A by Helicobacter mustelae and H-pylori - Reply. Letters [Details]
Drumm, B,Rowland, M,Imrie, C (1999) Sensitivity of urease-based test on diagnosis of Helicobacter pylori in children and the elderly. Letters [Details]
Vaughan, D,Drumm, B (1999) Treatment of fistulas with granulocyte colony-stimulating factor in a patient with Crohn's disease. Letters [Details]
Clyne, M,Drumm, B (1998) No correlation between H-pylori and blood groups in gastric cancer - Reply. Letters [Details]
LAMBERT, I,CLYNE, M,DRUMM, B (1993) HELICOBACTER-PYLORI IN DENTAL PLAQUES. Letters [Details]
DRUMM, B,SHERMAN, P (1992) HELICOBACTER-PYLORI AND GASTRITIS. Letters [Details]

Research

Research Interests

RESEARCH.

 

1) The pathogenesis of Helicobacter pylori infection.

Over the past 20 years my colleague Dr Marguerite Clyne and I have worked on characterising the mechanism by which H pylori attaches to the gastric mucosa. We developed unique in vitro models of infection to characterise this interaction. This work has resulted in several publications in the world's leading journal in this area, Gastroenterology, and in journals such as Proceedings of the National Academy of Sciences.

 

2) The epidemiology of Helicobacter pylori.

Within our group we have developed one of the world's leading units studying the acquisition and transmission of this infection. The epidemiology of H. pylori is of great importance as it explains the remarkable decrease in the prevalence of two of the world's most important diseases in the 20th century peptic ulcer disease and gastric cancer. We have conducted the only prospective study on the acquisition of H pylori infection. Our comprehensively characterised population from all across Ireland provides the basis for continuing studies in this important area. Our studies have been published on a number of occasions in The New England Journal of Medicine and in Gastroenterology. Our group have been invited to provide commentaries on the epidemiology of H. pylori on  two occasions for The Lancet.

 

3) Paediatric gastrointestinal and liver disease.

Because of the large population attending our national centre for Paediatric Gastrointestinal diseases we have contributed extensively to the literature in relation to this specialty. These studies have varied from the management of children with stress-related gastrointestinal symptoms to defining the optimal method for carrying out colonoscopy in children. Members of our group have been to the forefront internationally in characterising the oral manifestations of Crohn's disease and the natural history of this condition.

We were the first group in the world to report on the use of granulocyte colony stimulating factor as a novel approach to treating Crohn's disease. There are now groups all across the world studying the use of stimulating factors in treating inflammatory bowel disease.

 

4) Following my return to academic work, having spent 5 years as CEO of the Irish health service, I am developing programs for healthcare professionals to become skilled in the delivery of care for patients rather than simply focusing on treatment and outcome.  Clinicians can become leaders in changing the emphasis in healthcare from simply providing technical assistance to a holistic approach to the needs of patients which include care as well as treatment. Research in this area will be of significant importance over the next 20 years.

Research Projects

Sponsor : The Wellcome Trust (WT)
Title : The role of the oxidative pertose phosphate pathway in helicobacter induced apoptosis in primary culture of gastric cells from a ferret
Start Date / End Date : 01-JUL-01 / 04-AUG-01
Sponsor : The Wellcome Trust (WT)
Title : No Project title to migrate.
Start Date / End Date : 01-OCT-97 / 30-SEP-02