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Carel Le Roux

Full Professor of Experimental Pathology

Conway Institute
S57
Diabetes Complications Research Centre
Conway Institute
UCD
Dublin 4

Tel: +353 1 716 6831
Email: carel.leroux@ucd.ie

Biography

Professor Carel le Roux (MBChB, MSC, FRCP, FRCPath, PhD) graduated from medical school in Pretoria South Africa, completed his Senior House Officer training at Barts and The London Hospital, his SpR training in metabolic medicine at the Hammersmith Hospitals and his PhD at Imperial College London. He was appointed as Senior Lecturer and promoted to Reader in 2009 at Imperial. He accepted a Chair as Head of Pathology at University College Dublin in 2011. He received the President of Ireland Young Researcher Award from Science Foundation Ireland, a Clinician Scientist Award from the National Institute Health Research in the UK and a Wellcome Trust Clinical Research Fellowship amongst others.

A popular lecturer at undergraduate level, national and international conferences he has also supervised several MSc, MD and PhD students, many of whom have gone on to successful academic careers.

After establishing a successful independent research group he published numerous high impact papers over the years that have influenced his field. In particular, his translational research on the understanding of the physiological role and pathological changes in appetite control and the impact of bariatric surgery on diabetes has been widely acknowledged. He has also been able to take up a variety of editorial positions of peer reviewed journals.

Working within the Diabetes Complications Research Centre and the Section of Surgery and Surgical Specialities the focus of his research is primarily concerned with increased mortality and morbidity associated with obesity and diabetes. A better mechanistic understanding of how the "gut talks to the brain" will allow safer and more effective treatments to be used in future. To this end the role of gut hormones, bile acids and changes in food preference are areas of interest.

                                                                                                                                                              

Professional

Honours and Awards

Year: 2015.
Title: Robert Graves Lecture
Year: 2006.
Title: Association for Clinical Biochemsitry¿s Professor¿s prize for young investigators
Year: 2008.
Title: Cuthbertson Medal for achievements in nutrition
Year: 2008.
Title: Alberta Heritage Foundation for Medical Research Lecturer Award
Year: 2008.
Title: Young Investigator: European Association for Study of Obesity
Year: 2012.
Title: Nicola Scopinaro lecture award
Year: 2014.
Title: International Federation for Clinical Chemistry visiting lecturer award
Year: 2002.
Title: Wellcome Clinical Fellowship
Year: 2006.
Title: Department of Health Clinician Scientist award
Year: 2014.
Title: President of Ireland Young Researcher Award

Associations

Association: Royal College of Physicians (UK), Function/Role: Fellow
Association: Faculty of Pathology, Royal College of Physicians of Ireland, Function/Role: Vice Dean
Association: Royal College of Pathologists, Function/Role: Fellow
       

Committees

Committee : Metabolic Surgery committee of the International Federation for Surgery for Obesity
Committee : UCD Pathology Board
Committee : Irish Society for Clinical Nutrition and Metabolism (IrSPEN)
Committee : Board of the Faculty of Pathology, Roayl College of Physicians of Ireland
 

Education

Year 2000 Institution: Royal College of Physicians UK
Qualification: FRCP Subject:
Year 2005 Institution: University of London
Qualification: PhD Subject:
Year 1996 Institution: University of Pretoria, S.Afri
Qualification: MBChB Subject:
Year 2008 Institution:
Qualification: FRC Path Subject:
Year 2001 Institution: University of London
Qualification: MSc Subject:

Languages

Dutch:
English:

Consultancy

Client: University of Copenhagen
 

Journals Edited

Surgery For Obesity And Related Diseases: Reviewer.
Obesity Surgery: Reviewer.
International Journal Of Obesity: Reviewer.
American Journal Of Physiology: Reviewer.
Lancet: Reviewer.
Cell Metabolism: Reviewer.
Nature: Reviewer.

Other Activities

Professor le Roux was ranked as the leading clinician scientists working in bariatric surgery in 2015 on Expertscape http://www.expertscape.com/ex/bariatrics

 

Expertscape simply uses the literature to score people on any topic. It takes no surveys, but is soley based on articles published in medical journals. Peer review is the hallmark of medical journal articles. 

Publications

Books

Miras, A.D. and Le Roux, C.W. (2014) Mechanisms of bariatric surgery. : Springer New York. [DOI] [Details]
   

Peer Reviewed Journals

Cohen RV, Luque A, Junqueira S, Ribeiro RA, Le Roux CW. (2017) 'What is the impact on the healthcare system if access to bariatric surgery is delayed?'. Surgery for Obesity and Related Diseases, . [Details]
Ooi GJ, Doyle L, Tie T, Wentworth JM, Laurie C, Earnest A, Cowley MA, Sikaris K, le Roux CW, Burton PR, O'Brien PE, Brown WA. (2017) 'Weight loss after laparoscopic adjustable gastric band and resolution of the metabolic syndrome and its components'. International Journal of Obesity, . [DOI] [Details]
Miras AD, Herring R, Vusirikala A, Shojaee-Moradi F, Jackson NC, Chandaria S, Jackson SN, Goldstone AP, Hakim N, Patel AG, Umpleby AM, Le Roux CW. (2017) 'Measurement of hepatic insulin sensitivity early after the bypass of the proximal small bowel in humans'. Obesity Science & Practice, 3 (1):95-98. [DOI] [Details]
Mossberg KE, Pournaras DJ, Welbourn R, le Roux CW, Brogren H (2017) 'Differential response of plasma plasminogen activator inhibitor 1 after weight loss surgery in patients with or without type 2 diabetes'. Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery, . [Details]
Neff KJ, Baud G, Raverdy V, Caiazzo R, Verkindt H, Noel C, le Roux CW, Pattou F. (2017) 'Renal Function and Remission of Hypertension After Bariatric Surgery: a 5-Year Prospective Cohort Study'. Obesity Surgery, . [Details]
Neff KJ, Elliott JA, Corteville C, Abegg K, Boza C, Lutz TA, Docherty NG, le Roux CW. (2017) 'Effect of Roux-en-Y gastric bypass and diet-induced weight loss on diabetic kidney disease in the Zucker diabetic fatty rat'. Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery, . [Details]
Giblin L, McGrath BA, Murray BA, le Roux CW, Docherty NG, McSweeney PL, Kelly AL. (2017) 'Letter to the Editor Regarding Equivalent Increases in Circulating GLP-1 Following Jejunal Delivery of Intact and Hydrolysed Casein: Relevance to Satiety Induction following Bariatric Surgery'. Obesity Surgery, . [Details]
Cohen RV, Pereira TV, Aboud CM, Caravatto PP, Petry TB, Correa JL, Schiavon CA, Correa M, Pompílio CE, Pechy FN, le Roux CW; (2017) 'Microvascular Outcomes after Metabolic Surgery (MOMS) in patients with type 2 diabetes mellitus and class I obesity: rationale and design for a randomised controlled trial'. BMJ Open, . [Details]
Pournaras DJ, Hardwick RH, le Roux CW. (2017) 'Gastrointestinal surgery for obesity and cancer: 2 sides of the same coin'. Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery, . [Details]
Hyde KM, Blonde GD, le Roux CW, Spector AC. (2017) 'Liraglutide suppression of caloric intake competes with the intake-promoting effects of a palatable cafeteria diet, but does not impact food or macronutrient selection'. Physiology & behavior, . [Details]
Nielsen MS, Christensen BJ, Ritz C, Rasmussen S, Hansen TT, Bredie WLP, le Roux CW, Sjödin A, Schmidt JB (2017) 'Roux-En-Y Gastric Bypass and Sleeve Gastrectomy Does Not Affect Food Preferences When Assessed by an Ad libitum Buffet Meal'. Obesity Surgery, . [Details]
Laurenius A, Werling M, le Roux CW, Fändriks L, Olbers T. (2017) 'Dumping symptoms is triggered by fat as well as carbohydrates in patients operated with Roux-en-Y gastric bypass'. Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery, . [Details]
Miras AD, le Roux CW. (2017) 'Metabolic Surgery in a Pill'. Cell Metabolism, . [Details]
Cohen RV, Luque A, Junqueira S, Ribeiro RA, Le Roux CW. (2017) 'What is the impact on the healthcare system if access to bariatric surgery is delayed?'. Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery, . [Details]
Abdelaal M, le Roux CW, Docherty NG. (2017) 'Morbidity and mortality associated with obesity'. Annals of Translational Medicine, . [Details]
Docherty NG, le Roux CW (2016) 'Reconfiguration of the small intestine and diabetes remitting effects of Roux-en-Y gastric bypass surgery'. Current Opinion in Gastroenterology, 32 (2):61-66. [DOI] [Details]
Pournaras DJ, le Roux CW (2016) 'Bariatric Surgery and Decreasing Vascular Risk'. Angiology, . [Details]
Jung J, Ha TK, Lee J, Lho Y, Nam M, Lee D, le Roux CW, Ryu DH, Ha E, Hwang GS. (2016) 'Changes in one-carbon metabolism after duodenal-jejunal bypass surgery'. American Journal of Physiology - Endocrinology and Metabolism, . [Details]
Mathes CM, Letourneau C, Blonde GD, le Roux CW, Spector AC. (2016) 'Roux-en-Y gastric bypass in rats progressively decreases the proportion of fat calories selected from a palatable cafeteria diet'. American journal of physiology. Regulatory, integrative and comparative physiology, . [Details]
Pournaras DJ, Nygren J, Hagström-Toft E, Arner P, le Roux CW, Thorell A. (2016) 'Improved glucose metabolism after gastric bypass: evolution of the paradigm'. Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery, . [Details]
Elliott JA, Docherty NG, Eckhardt HG, Doyle SL, Guinan EM, Ravi N, Reynolds JV, le Roux CW. (2016) 'Weight Loss, Satiety, and the Postprandial Gut Hormone Response After Esophagectomy: A Prospective Study'. Annals of Surgery, . [Details]
Bächler T, le Roux CW, Bueter M. (2016) 'How do patients' clinical phenotype and the physiological mechanisms of the operations impact the choice of bariatric procedure?'. Clinical and Experimental Gastroenterology, . [Details]
Nair M, le Roux CW, Docherty NG. (2016) 'Mechanisms underpinning remission of albuminuria following bariatric surgery'. Current Opinion in Endocrinology, Diabetes and Obesity, . [Details]
Hunt KF, Dunn JT, le Roux CW, Reed LJ, Marsden PK, Patel AG, Amiel SA. (2016) 'Differences in Regional Brain Responses to Food Ingestion After Roux-en-Y Gastric Bypass and the Role of Gut Peptides: A Neuroimaging Study'. Diabetes Care, . [Details]
Zanchi D, Meyer-Gerspach AC, Suenderhauf C, Janach K, le Roux CW, Haller S, Drewe J, Beglinger C, Wölnerhanssen BK, Borgwardt S. (2016) 'Differential effects of L-tryptophan and L-leucine administration on brain resting state functional networks and plasma hormone levels'. Scientific Reports, . [Details]
Gorman DM, le Roux CW, Docherty NG. (2016) 'The Effect of Bariatric Surgery on Diabetic Retinopathy: Good, Bad, or Both?'. Diabetes and Metabolism Journal, . [Details]
Nair M, le Roux CW, Docherty NG. (2016) 'Measuring changes in renal function after bariatric surgery: Why estimated glomerular filtration rate is not good enough'. Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery, . [Details]
Murphy CF, le Roux CW. (2016) 'The Neurobiological Impact of Ghrelin Suppression after Oesophagectomy'. International Journal of Molecular Sciences, . [Details]
O'Neill KN, Finucane FM, le Roux CW, Fitzgerald AP, Kearney PM. (2016) 'Unmet need for bariatric surgery'. Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery, . [Details]
Maghsoodi N, Alaghband-Zadeh J;Cross G;Werling M;Fandriks L;Docherty NG;Olbers T;Dew T;Sherwood R;Vincent RP;Le Roux CW (2016) 'ANNALS EXPRESS: Elevated Fasting & Post-prandial C-Terminal Telopeptide (CTX) after Roux-en-Y gastric bypass (RYGB)'. Annals of Clinical Biochemistry, . [DOI] [Details]
Melvin A, le Roux CW;Docherty NG (2016) 'The Gut as an Endocrine Organ: Role in the Regulation of Food Intake and Body Weight'. Current Atherosclerosis Reports, 18 (8). [DOI] [Details]
Belgaumkar AP, Vincent RP;Carswell KA;Hughes RD;Alaghband-Zadeh J;Mitry RR;le Roux CW;Patel AG (2016) 'Changes in Bile Acid Profile After Laparoscopic Sleeve Gastrectomy are Associated with Improvements in Metabolic Profile and Fatty Liver Disease'. Obesity Surgery, 26 (6):1195-1202. [DOI] [Details]
de Jonge C, Rensen SS;Verdam FJ;Vincent RP;Bloom SR;Buurman WA;le Roux CW;Bouvy ND;Greve JW (2016) 'Impact of Duodenal-Jejunal Exclusion on Satiety Hormones'. Obesity Surgery, 26 (3):672-678. [DOI] [Details]
Goldstone AP, Miras AD;Scholtz S;Jackson S;Neff KJ;P¿¿nicaud L;Geoghegan J;Chhina N;Durighel G;Bell JD;Meillon S;le Roux CW (2016) 'Link Between Increased Satiety Gut Hormones and Reduced Food Reward After Gastric Bypass Surgery for Obesity'. The Journal of clinical endocrinology and metabolism, 101 (2):599-609. [DOI] [Details]
Qvigstad, E. and Gulseth, H.L. and Risstad, H. and Le Roux, C.W. and Berg, T.J. and Mala, T. and Kristinsson, J.A. (2016) 'A novel technique of Roux-en-Y gastric bypass reversal for postprandial hyperinsulinemic hypoglycaemia: A case report'. International Journal of Surgery Case Reports, 21 :91-94. Available Online [DOI] [Details]
Elliott, J.A. and le Roux, C.W. (2016) 'Type 2 diabetes with BMI<30 kg/m2: Can we predict success of metabolic surgery?'. Surgery for Obesity and Related Diseases, . Available Online [DOI] [Details]
Van Avesaat, M. and Troost, F.J. and Westerterp-Plantenga, M.S. and Helyes, Z. and Le Roux, C.W. and Dekker, J. and Masclee, A.A.M. and Keszthelyi, D. (2016) 'Capsaicin-induced satiety is associated with gastrointestinal distress but not with the release of satiety hormones'. American Journal of Clinical Nutrition, 103 (2):305-313. Available Online [DOI] [Details]
Abdeen, G. and le Roux, C.W. (2016) 'Mechanism Underlying the Weight Loss and Complications of Roux-en-Y Gastric Bypass. Review'. Obesity Surgery, 26 (2):410-421. Available Online [DOI] [Details]
de Jonge, C. and Rensen, S.S. and Verdam, F.J. and Vincent, R.P. and Bloom, S.R. and Buurman, W.A. and le Roux, C.W. and Bouvy, N.D. and Greve, J.W.M. (2016) 'Impact of Duodenal-Jejunal Exclusion on Satiety Hormones'. Obesity Surgery, 26 (3):672-678. Available Online [DOI] [Details]
Welbourn, R. and Dixon, J. and Barth, J.H. and Finer, N. and Hughes, C.A. and le Roux, C.W. and Wass, J. (2016) 'NICE-Accredited Commissioning Guidance for Weight Assessment and Management Clinics: a Model for a Specialist Multidisciplinary Team Approach for People with Severe Obesity'. Obesity Surgery, 26 (3):649-659. Available Online [DOI] [Details]
Docherty, N.G. and Le Roux, C.W. (2016) 'Reconfiguration of the small intestine and diabetes remitting effects of Roux-en-Y gastric bypass surgery'. Current Opinion in Gastroenterology, 32 (2):61-66. Available Online [DOI] [Details]
Melvin, A. and le Roux, C.W. and Docherty, N.G. (2016) 'Which organ is responsible for the pathogenesis of obesity?'. Irish Medical Journal, 109 (4):397. Available Online [Details]
Del Genio, G. and Gagner, M. and Limongelli, P. and Tolone, S. and Pournaras, D. and Le Roux, C.W. and Brusciano, L. and Licia Mozzillo, A. and Del Genio, F. and Docimo, L. (2016) 'Remission of type 2 diabetes in patients undergoing biliointestinal bypass for morbid obesity: A new surgical treatment'. Surgery for Obesity and Related Diseases, 12 (4):815-821. Available Online [DOI] [Details]
Wilding, J.P.H. and Overgaard, R.V. and Jacobsen, L.V. and Jensen, C.B. and Le Roux, C.W. (2016) 'Exposure-response analyses of liraglutide 3.0mg for weight management'. Diabetes, Obesity and Metabolism, 18 (5):491-499. Available Online [DOI] [Details]
Neff, K.J. and le Roux, C.W. (2016) 'Bariatric surgery: traversing the CROSSROADS into mainstream diabetes care'. Diabetologia, 59 (5):942-944. Available Online [DOI] [Details]
Welbourn, R. and Le Roux, C.W. and Owen-Smith, A. and Wordsworth, S. and Blazeby, J.M. (2016) 'Why the NHS should do more bariatric surgery; how much should we do?'. BMJ (Online), 353 . Available Online [DOI] [Details]
Hansen, T.T. and Jakobsen, T.A. and Nielsen, M.S. and Sjödin, A. and Le Roux, C.W. and Schmidt, J.B. (2016) 'Hedonic Changes in Food Choices Following Roux-en-Y Gastric Bypass'. Obesity Surgery, :1-10. Available Online [DOI] [Details]
Cohen, R.V. and Shikora, S. and Petry, T. and Caravatto, P.P. and Le Roux, C.W. (2016) 'The Diabetes Surgery Summit II Guidelines: a Disease-Based Clinical Recommendation'. Obesity Surgery, :1-3. Available Online [DOI] [Details]
Belgaumkar, A.P. and Vincent, R.P. and Carswell, K.A. and Hughes, R.D. and Alaghband-Zadeh, J. and Mitry, R.R. and le Roux, C.W. and Patel, A.G. (2016) 'Changes in Bile Acid Profile After Laparoscopic Sleeve Gastrectomy are Associated with Improvements in Metabolic Profile and Fatty Liver Disease'. Obesity Surgery, 26 (6):1195-1202. Available Online [DOI] [Details]
Coluzzi, I. and Raparelli, L. and Guarnacci, L. and Paone, E. and Del Genio, G. and Le Roux, C.W. and Silecchia, G. (2016) 'Food Intake and Changes in Eating Behavior After Laparoscopic Sleeve Gastrectomy'. Obesity Surgery, :1-9. Available Online [DOI] [Details]
Goldstone, A.P. and Miras, A.D. and Scholtz, S. and Jackson, S. and Neff, K.J. and Pénicaud, L. and Geoghegan, J. and Chhina, N. and Durighel, G. and Bell, J.D. and Meillon, S. and Le Roux, C.W. (2016) 'Link between increased satiety gut hormones and reduced food reward after gastric bypass surgery for obesity'. Journal of Clinical Endocrinology and Metabolism, 101 (2):599-609. Available Online [DOI] [Details]
Miras, A. D. and Al-Najim, W. and Jackson, S. N. and McGirr, J. and Cotter, L. and Tharakan, G. and Vusirikala, A. and le Roux, C. W. and Prechtl, C. G. and Scholtz, S. (2015) 'PSYCHOLOGICAL CHARACTERISTICS, EATING BEHAVIOR, AND QUALITY OF LIFE ASSESSMENT OF OBESE PATIENTS UNDERGOING WEIGHT LOSS INTERVENTIONS'. Scandinavian Journal of Surgery, 104 (1, SI):10-17. [DOI] [Details]
Elliott JA, le Roux CW. (2015) 'How long should we make the biliopancreatic limb during Roux-en-Y gastric bypass?'. Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery, . [Details]
Docherty NG, Canney AL;le Roux CW (2015) 'Weight loss interventions and progression of diabetic kidney disease'. Current Diabetes Reports, 15 (8). [DOI] [Details]
Abegg K, Corteville C;Docherty NG;Boza C;Lutz TA;Mu¿¿oz R;le Roux CW (2015) 'Effect of bariatric surgery combined with medical therapy versus intensive medical therapy or calorie restriction and weight loss on glycemic control in Zucker diabetic fatty rats'. American journal of physiology. Regulatory, integrative and comparative physiology, 308 (4):1-9. [DOI] [Details]
Risstad H, S¿¿vik TT;Engstr¿¿m M;Aasheim ET;Fagerland MW;Ols¿¿n MF;Kristinsson JA;le Roux CW;B¿¿hmer T;Birkeland KI;Mala T;Olbers T (2015) 'Five-year outcomes after laparoscopic gastric bypass and laparoscopic duodenal switch in patients with body mass index of 50 to 60: a randomized clinical trial'. JAMA Surgery, 150 (4):352-361. [DOI] [Details]
Mathes CM, Bohnenkamp RA;Blonde GD;Letourneau C;Corteville C;Bueter M;Lutz TA;le Roux CW;Spector AC (2015) 'Gastric bypass in rats does not decrease appetitive behavior towards sweet or fatty fluids despite blunting preferential intake of sugar and fat'. Physiology & behavior, 142 :179-188. [DOI] [Details]
Wu Q, Li JV;Seyfried F;le Roux CW;Ashrafian H;Athanasiou T;Fenske W;Darzi A;Nicholson JK;Holmes E;Gooderham NJ (2015) 'Metabolic phenotype-microRNA data fusion analysis of the systemic consequences of Roux-en-Y gastric bypass surgery'. International journal of obesity (2005), 39 (7):1126-1134. [DOI] [Details]
Sathyapalan T, Thatcher NJ;Hammersley R;Rigby AS;Courts FL;Pechlivanis A;Gooderham NJ;Holmes E;le Roux CW;Atkin SL (2015) 'Aspartame sensitivity? A double blind randomised crossover study'. PLoS ONE, 10 (3). [DOI] [Details]
Chuah LL, Miras AD;Papamargaritis D;Jackson SN;Olbers T;le Roux CW (2015) 'Impact of perioperative management of glycemia in severely obese diabetic patients undergoing gastric bypass surgery'. Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery, 11 (3):578-584. [DOI] [Details]
Arora T, Velagapudi V;Pournaras DJ;Welbourn R;le Roux CW;Ore¿¿i¿¿ M;B¿¿ckhed F (2015) 'Roux-en-Y Gastric Bypass Surgery Induces Early Plasma Metabolomic and Lipidomic Alterations in Humans Associated with Diabetes Remission'. PLoS ONE, 10 (5). [DOI] [Details]
Maguire PJ, Power KA;O'Higgins AC;Jackson S;Harley R;le Roux CW;Turner MJ (2015) 'Maternal C-reactive protein in early pregnancy'. European Journal of Obstetrics, Gynecology and Reproductive Biology, 193 :79-82. [DOI] [Details]
Spector AC, le Roux CW;Munger SD;Travers SP;Sclafani A;Mennella JA (2015) 'Proceedings of the 2015 A.S.P.E.N. Research Workshop-Taste Signaling: Impact on Food Selection, Intake, and Health'. JPEN. Journal of parenteral and enteral nutrition, . [DOI] [Details]
Pi-Sunyer X, Astrup A;Fujioka K;Greenway F;Halpern A;Krempf M;Lau DC;le Roux CW;Violante Ortiz R;Jensen CB;Wilding JP; (2015) 'A Randomized, Controlled Trial of 3.0 mg of Liraglutide in Weight Management'. The New England journal of medicine, 373 (1):11-22. [DOI] [Details]
Elliott JA, Jackson S;King S;McHugh R;Docherty NG;Reynolds JV;le Roux CW (2015) 'Gut Hormone Suppression Increases Food Intake After Esophagectomy With Gastric Conduit Reconstruction'. Annals of Surgery, 262 (5):824-830. [DOI] [Details]
Docherty NG, Le Roux CW (2015) 'Physiological adaptations following Roux-en-Y gastric bypass and the identification of targets for bariatric mimetic pharmacotherapy'. Current Opinion in Pharmacology, 25 :23-29. [DOI] [Details]
le Roux CW, Engstr¿¿m M;Bj¿¿rnfot N;F¿¿ndriks L;Docherty NG (2015) 'Equivalent Increases in Circulating GLP-1 Following Jejunal Delivery of Intact and Hydrolysed Casein: Relevance to Satiety Induction Following Bariatric Surgery'. Obesity Surgery, . [DOI] [Details]
van Avesaat M, Troost FJ;Westerterp-Plantenga MS;Helyes Z;Le Roux CW;Dekker J;Masclee AA;Keszthelyi D (2015) 'Capsaicin-induced satiety is associated with gastrointestinal distress but not with the release of satiety hormones'. American Journal of Clinical Nutrition, . [DOI] [Details]
Werling M, F¿¿ndriks L;Olbers T;Bueter M;Sj¿¿str¿¿m L;L¿¿nroth H;Wallenius V;Stenl¿¿f K;le Roux CW (2015) 'Roux-en-Y Gastric Bypass Surgery Increases Respiratory Quotient and Energy Expenditure during Food Intake'. PLoS ONE, 10 (6). [DOI] [Details]
Alsters SI, Goldstone AP;Buxton JL;Zekavati A;Sosinsky A;Yiorkas AM;Holder S;Klaber RE;Bridges N;van Haelst MM;le Roux CW;Walley AJ;Walters RG;Mueller M;Blakemore AI (2015) 'Truncating Homozygous Mutation of Carboxypeptidase E (CPE) in a Morbidly Obese Female with Type 2 Diabetes Mellitus, Intellectual Disability and Hypogonadotrophic Hypogonadism'. PLoS ONE, 10 (6). [DOI] [Details]
Dutia R, Embrey M;O'Brien S;Haeusler RA;Ag¿¿nor KK;Homel P;McGinty J;Vincent RP;Alaghband-Zadeh J;Staels B;le Roux CW;Yu J;Laferr¿¿re B (2015) 'Temporal changes in bile acid levels and 12¿¿-hydroxylation after Roux-en-Y gastric bypass surgery in type 2 diabetes'. International Journal of Obesity, 39 (5):806-813. [DOI] [Details]
Boxwell AJ, Chen Z;Mathes CM;Spector AC;Le Roux CW;Travers SP;Travers JB (2015) 'Effects of high-fat diet and gastric bypass on neurons in the caudal solitary nucleus'. Physiology and Behavior, . [DOI] [Details]
Tremaroli V, Karlsson F;Werling M;St¿¿hlman M;Kovatcheva-Datchary P;Olbers T;F¿¿ndriks L;le Roux CW;Nielsen J;B¿¿ckhed F (2015) 'Roux-en-Y Gastric Bypass and Vertical Banded Gastroplasty Induce Long-Term Changes on the Human Gut Microbiome Contributing to Fat Mass Regulation'. Cell Metabolism, 22 (2):228-238. [DOI] [Details]
Mathes CM, Bohnenkamp RA;le Roux CW;Spector AC (2015) 'Reduced sweet and fatty fluid intake after Roux-en-Y gastric bypass in rats is dependent on experience without change in stimulus motivational potency'. American Journal of Physiology - Regulatory Integrative and Comparative Physiology, 309 (8):1-74. [DOI] [Details]
Pournaras DJ, le Roux CW (2015) 'Type 2 diabetes: multimodal treatment of a complex disease'. Lancet, 386 (9997):936-937. [DOI] [Details]
Scholtz S, Goldstone AP;le Roux CW (2015) 'Changes in Reward after Gastric Bypass: the Advantages and Disadvantages'. Current Atherosclerosis Reports, 17 (10). [DOI] [Details]
Maguire PJ, Power KA, O'Higgins AC, Jackson S, Harley R, le Roux CW, Turner MJ (2015) 'Maternal C-reactive protein in early pregnancy'. European Journal of Obstetrics & Gynecology and Reproductive Biology, . [Details]
Belgaumkar AP, Vincent RP, Carswell KA, Hughes RD, Alaghband-Zadeh J, Mitry RR, le Roux CW, Patel AG (2015) 'Changes in Bile Acid Profile After Laparoscopic Sleeve Gastrectomy are Associated with Improvements in Metabolic Profile and Fatty Liver Disease'. Obesity Surgery, . [Details]
Abegg, K., Corteville, C., Docherty, N. G., Boza, C., Lutz, T. A., Munoz, R., le Roux, C. W. (2015) 'Effect of bariatric surgery combined with medical therapy versus intensive medical therapy or calorie restriction and weight loss on glycemic control in Zucker diabetic fatty rats'. American Journal of Physiology - Regulatory Integrative and Comparative Physiology, 308 (4):9. Available Online [Details]
Docherty, N. G., Canney, A. L., le Roux, C. W. (2015) 'Weight Loss Interventions and Progression of Diabetic Kidney Disease'. Current Diabetes Reports, 15 (8):625. Available Online [Details]
Xavier Pi-Sunyer, M.D., Arne Astrup, M.D., D.M.Sc., Ken Fujioka, M.D., Frank Greenway, M.D., Alfredo Halpern, M.D., Michel Krempf, M.D., Ph.D., David C.W. Lau, M.D., Ph.D., Carel W. le Roux, F.R.C.P., Ph.D., Rafael Violante Ortiz, M.D., Christine Bjørn Jensen, M.D., Ph.D., and John P.H. Wilding, D.M. (2015) 'A Randomized, Controlled Trial of 3.0 mg of Liraglutide in Weight Management'. New England Journal of Medicine, 373 :11-22. Available Online [DOI] [Details]
Goyale, A., Ashley, S.L., Taylor, D.R., Elnenaei, M.O., Alaghband-Zadeh, J., Sherwood, R.A., le Roux, C.W., Vincent, R.P. (2015) 'Predicting refeeding hypophosphataemia: insulin growth factor 1 (IGF-1) as a diagnostic biochemical marker for clinical practice'. Annals of Clinical Biochemistry, 52 (1):82-87. Available Online [DOI] [Details]
Sam, A.H., Sleeth, M.L., Thomas, E.L., Ismail, N.A., Daud, N.M., Chambers, E., Shojaee-Moradie, F., Umpleby, M., Goldstone, A.P., Le Roux, C.W., Bech, P., Busbridge, M., Laurie, R., Cuthbertson, D.J., Buckley, A., Ghatei, M.A., Bloom, S.R., Frost, G.S., Bell, J.D., Murphy, K.G. (2015) 'Circulating pancreatic polypeptide concentrations predict visceral and liver fat content'. Journal of Clinical Endocrinology and Metabolism, 100 (3):1048-1052. Available Online [DOI] [Details]
Chuah, L.L., Miras, A.D., Papamargaritis, D., Jackson, S.N., Olbers, T., le Roux, C.W. (2015) 'Impact of perioperative management of glycemia in severely obese diabetic patients undergoing gastric bypass surgery'. Surgery for Obesity and Related Diseases, . Available Online [DOI] [Details]
Risstad, H., Søvik, T.T., Engström, M., Aasheim, E.T., Fagerland, M.W., Olsén, M.F., Kristinsson, J.A., Le Roux, C.W., Bøhmer, T., Birkeland, K.I., Mala, T., Olbers, T. (2015) 'Five-year outcomes after laparoscopic gastric bypass and laparoscopic duodenal switch in patients with body mass index of 50 to 60: A randomized clinical trial'. JAMA Surgery, 150 (4):352-361. Available Online [DOI] [Details]
Papamargaritis, D., Aasheim, E.T., Sampson, B., le Roux, C.W. (2015) 'Copper, selenium and zinc levels after bariatric surgery in patients recommended to take multivitamin-mineral supplementation'. Journal of Trace Elements in Medicine and Biology, 31 :167-172. Available Online [DOI] [Details]
Lho, Y., Le Roux, C.W., Park, H.S., Kim, G.S., Jung, J., Hwang, G.-S., Seo, Y.K., Ha, T.K., Ha, E. (2015) 'Changes in Glucose Metabolism in Vertical Sleeve Gastrectomy'. Obesity Surgery, . Available Online [DOI] [Details]
Wu, Q., Li, J.V., Seyfried, F., le Roux, C.W., Ashrafian, H., Athanasiou, T., Fenske, W., Darzi, A., Nicholson, J.K., Holmes, E., Gooderham, N.J. (2015) 'Metabolic phenotype-microRNA data fusion analysis of the systemic consequences of Roux-en-Y gastric bypass surgery'. International Journal of Obesity, . Available Online [DOI] [Details]
Miras, A.D., Chuah, L.L., Khalil, N., Nicotra, A., Vusirikala, A., Baqai, N., Graham, C., Ravindra, S., Lascaratos, G., Oliver, N., Le Roux, C.W. (2015) 'Type 2 diabetes mellitus and microvascular complications 1 year after Roux-en-Y gastric bypass: a caseâ¿¿control study'. Diabetologia, . Available Online [DOI] [Details]
Tham, J.C., le Roux, C.W., Docherty, N.G. (2015) 'Cardiovascular, Renal and Overall Health Outcomes After Bariatric Surgery'. Current Cardiology Reports, 17 (5). Available Online [DOI] [Details]
Arora, T., Velagapudi, V., Pournaras, D.J., Welbourn, R., Le Roux, C.W., Orešič, M., Bäckhed, F. (2015) 'Roux-en-Y gastric bypass surgery induces early plasma metabolomic and lipidomic alterations in humans associated with diabetes remission'. PLoS ONE, 10 (5). Available Online [DOI] [Details]
Sathyapalan, Thozhukat and Thatcher, Natalie J. and Hammersley, Richard and Rigby, Alan S. and Pechlivanis, Alexandros and Gooderham, Nigel J. and Holmes, Elaine and le Roux, Carel W. and Atkin, Stephen L. and Courts, Fraser (2015) 'Aspartame Sensitivity? A Double Blind Randomised Crossover Study'. PLoS ONE, 10 (3). [DOI] [Details]
Mathes, Clare M. and Bohnenkamp, Ryan A. and Blonde, Ginger D. and Letourneau, Chanel and Corteville, Caroline and Bueter, Marco and Lutz, Thomas A. and le Roux, Carel W. and Spector, Alan C. (2015) 'Gastric bypass in rats does not decrease appetitive behavior towards sweet or fatty fluids despite blunting preferential intake of sugar and fat'. Physiology & Behavior, 142 :179-188. [DOI] [Details]
Wilding, J. and Astrup, A. and Fujioka, K. and Greenway, F. and Krempf, M. and Lau, D. and Le Roux, C. W. and Lilleore, S. K. and Jensen, T. and Violante Ortiz, R. (2015) 'In overweight and obese adults, liraglutide 3.0mg reduces the prevalence of prediabetes and delays the onset of Type 2 diabetes: SCALE obesity and pre-diabetes trial'. Diabetic Medicine, 32 (1, SI):71. [Details]
Wilding, J. and Lau, D. and Astrup, A. and Fujioka, K. and Greenway, F. and Krempf, M. and Le Roux, C. W. and Violante Ortiz, R. and Lilleore, S. K. and Jensen, T. and Pi-Sunyer, X. (2015) 'Safety and tolerability of liraglutide 3.0mg following 56 weeks of randomised treatment in overweight and obese adults: SCALE obesity and pre-diabetes trial'. Diabetic Medicine, 32 (1, SI):70. [Details]
Taylor DR, Alaghband-Zadeh J, Cross GF, Omar S, le Roux CW, Vincent RP. (2014) 'Urine Bile Acids Relate to Glucose Control in Patients with Type 2 Diabetes Mellitus and a Body Mass Index Below 30 kg/m2'. PLoS ONE, . [DOI] [Details]
Kim JY, Ha TK, le Roux CW. (2014) 'Metabolic effects of gastrectomy with or without omentectomy in gastric cancer'. Hepato-Gastroenterology, 61 (134):1830-1834. [Details]
Angelopoulos T, Kokkinos A, Liaskos C, Tentolouris N, Alexiadou K, Miras AD, Mourouzis I, Perrea D, Pantos C, Katsilambros N, Bloom SR, le Roux CW. (2014) 'The effect of slow spaced eating on hunger and satiety in overweight and obese patients with type 2 diabetes mellitus'. BMJ Open Diabetes Research & Care, . [DOI] [Details]
Tako AA, Kotiadis K, Vasilakis C, Miras A, le Roux CW. (2014) 'Improving patient waiting times: a simulation study of an obesity care service'. BMJ Quality and Safety, . [Details]
Lyons T, Neff KJ, Benn J, Chuah LL, le Roux CW, Gilchrist M. (2014) 'Body mass index and diabetes status do not affect postoperative infection rates after bariatric surgery'. Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery, . [Details]
Bächler T, Schiesser M, Lutz TA, le Roux CW, Bueter M. (2014) 'Where to begin and where to end? Preoperative assessment for patients undergoing metabolic surgery'. Digestive Surgery, . [Details]
Seyfried F, Bueter M, Spliethoff K, Miras AD, Abegg K, Lutz TA, le Roux CW. (2014) 'Roux-en Y gastric bypass is superior to duodeno-jejunal bypass in improving glycaemic control in Zucker diabetic fatty rats'. Obesity Surgery, . [Details]
Bhutta HY, Deelman TE, le Roux CW, Ashley SW, Rhoads DB, Tavakkoli A. (2014) 'Intestinal sweet-sensing pathways and metabolic changes after Roux-en-Y gastric bypass surgery'. American Journal of Physiology - Gastrointestinal and Liver Physiology, . [Details]
Elias E, Casselbrant A, Werling M, Abegg K, Vincent RP, Alaghband-Zadeh J, Olbers T, le Roux CW, Fändriks L, Wallenius V. (2014) 'Bone mineral density and expression of vitamin D receptor-dependent calcium uptake mechanisms in the proximal small intestine after bariatric surgery'. British Journal of Surgery, . [Details]
Miras AD, Seyfried F, Phinikaridou A, Andia ME, Christakis I, Spector AC, Botnar RM, le Roux CW. (2014) 'Rats fed diets with different energy contribution from fat do not differ in adiposity'. Obesity Facts, . [Details]
Docherty NG, le Roux CW (2014) 'Improvements in the metabolic milieu following Roux-en-Y gastric bypass and the arrest of diabetic kidney disease'. Experimental Physiology, 99 (9):1146-1153. [DOI] [Details]
Miras AD, le Roux CW (2014) 'Can medical therapy mimic the clinical efficacy or physiological effects of bariatric surgery?'. International Journal of Obesity, 38 (3):325-333. [DOI] [Details]
Buhmann H, le Roux CW;Bueter M (2014) 'The gut-brain axis in obesity'. Best Practice and Research in Clinical Gastroenterology, 28 (4):559-571. [DOI] [Details]
Werling M, F¿¿ndriks L;Royce VP;Cross GF;le Roux CW;Olbers T (2014) 'Preoperative assessment of gut hormones does not correlate to weight loss after Roux-en-Y gastric bypass surgery'. Surgery for Obesity and Related Diseases, 10 (5):822-828. [DOI] [Details]
Tham JC, Howes N;le Roux CW (2014) 'The role of bariatric surgery in the treatment of diabetes'. Therapeutic Advances in Chronic Disease, 5 (3):149-157. [DOI] [Details]
le Roux CW, Bueter M (2014) 'The physiology of altered eating behaviour after Roux-en-Y gastric bypass'. Experimental Physiology, 99 (9):1128-1132. [DOI] [Details]
Laurenius A, Werling M;Le Roux CW;F¿¿ndriks L;Olbers T (2014) 'More symptoms but similar blood glucose curve after oral carbohydrate provocation in patients with a history of hypoglycemia-like symptoms compared to asymptomatic patients after Roux-en-Y gastric bypass'. Surgery for Obesity and Related Diseases, 10 (6):1047-1054. [DOI] [Details]
Docherty, N. G., le Roux, C. W. (2014) 'Physiological and pathophysiological signalling between the gut and the kidney: role in diabetic kidney disease'. Experimental Physiology, 99 (9):1138-9. Available Online [Details]
Docherty, N. G., le Roux, C. W. (2014) 'Improvements in the metabolic milieu following Roux-en-Y gastric bypass and the arrest of diabetic kidney disease'. Experimental Physiology, 99 (9):1146-53. Available Online [Details]
Jackson, S., le Roux, C. W., Docherty, N. G. (2014) 'Bariatric surgery and microvascular complications of type 2 diabetes mellitus'. Current Atherosclerosis Reports, 16 (11):453. Available Online [Details]
Miras, A.D. and Risstad, H. and Baqai, N. and Law, S. and Søvik, T.T. and Mala, T. and Olbers, T. and Kristinsson, J.A. and Le Roux, C.W. (2014) 'Application of the International Diabetes Federation and American Diabetes Association criteria in the assessment of metabolic control after bariatric surgery'. Diabetes, Obesity and Metabolism, 16 (1):86-89. Available Online [Details]
Pournaras, D.J. and Le Roux, C.W. (2014) 'Can we predict diabetes remission after weight-loss surgery?'. The Lancet Diabetes and Endocrinology, 2 (1):4-6. Available Online [Details]
Carswell, K.A. and Vincent, R.P. and Belgaumkar, A.P. and Sherwood, R.A. and Amiel, S.A. and Patel, A.G. and Le Roux, C.W. (2014) 'The effect of bariatric surgery on intestinal absorption and transit time'. Obesity Surgery, 24 (5):796-805. Available Online [Details]
Neff, K.J. and Chuah, L.L. and Aasheim, E.T. and Jackson, S. and Dubb, S.S. and Radhakrishnan, S.T. and Sood, A.S. and Olbers, T. and Godsland, I.F. and Miras, A.D. and Le Roux, C.W. (2014) 'Beyond weight loss: Evaluating the multiple benefits of bariatric surgery after Roux-en-Y gastric bypass and adjustable gastric band'. Obesity Surgery, 24 (5):684-691. Available Online [Details]
Salinari, S. and Le Roux, C.W. and Bertuzzi, A. and Rubino, F. and Mingrone, G. (2014) 'Duodenal-jejunal bypass and jejunectomy improve insulin sensitivity in goto-kakizaki diabetic rats without changes in incretins or insulin secretion'. Diabetes, 63 (3):1069-1078. Available Online [Details]
Neff, K.J. and Prener, C. and Chuah, L.L. and O'Donnell, K. and Godsland, I.F. and Miras, A.D. and Le Roux, C.W. (2014) 'A holistic assessment of bariatric surgical outcomes in a northern irish cohort'. Irish Medical Journal, 107 (1). Available Online [Details]
Miras, A.D. and le Roux, C.W. (2014) 'Metabolic surgery: Shifting the focus from glycaemia and weight to end-organ health'. The Lancet Diabetes and Endocrinology, 2 (2):141-151. Available Online [Details]
Goyale A, Ashley SL, Taylor DR, Elnenaei MO, Alaghband-Zadeh J, Sherwood RA, le Roux CW, Vincent RP (2014) 'Predicting refeeding hypophosphataemia: Insulin growth factor 1 (IGF-1) as a diagnostic biochemical marker for clinical practice'. Annals of Clinical Biochemistry, . [Details]
Lyons T, Neff KJ, Benn J, Chuah LL, le Roux CW, Gilchrist M (2013) 'Body mass index and diabetes status do not affect postoperative infection rates after bariatric surgery'. Surgery For Obesity And Related Diseases, . [DOI] [Details]
Neff KJ, le Roux CW. (2013) 'Bariatric surgery: the indications in metabolic disease'. Digestive Surgery, . [Details]
Scholtz S, Miras AD, Chhina N, Prechtl CG, Sleeth ML, Daud NM, Ismail NA, Durighel G, Ahmed AR, Olbers T, Vincent RP, Alaghband-Zadeh J, Ghatei MA, Waldman AD, Frost GS, Bell JD, le Roux CW, Goldstone AP. (2013) 'Obese patients after gastric bypass surgery have lower brain-hedonic responses to food than after gastric banding'. Nutricion Hospitalaria, . [Details]
Chuah LL, Papamargaritis D, Pillai D, Krishnamoorthy A, le Roux CW. (2013) 'Morbidity and mortality of diabetes with surgery'. Nutricion Hospitalaria, . [Details]
Papamargaritis D, Miras AD, le Roux CW. (2013) 'Influence of diabetes surgery on gut hormones and incretins'. Nutricion Hospitalaria, . [Details]
Werling M, Vincent RP, Cross GF, Marschall HU, Fändriks L, Lönroth H, Taylor DR, Alaghband-Zadeh J, Olbers T, Le Roux CW. (2013) 'Enhanced fasting and post-prandial plasma bile acid responses after Roux-en-Y gastric bypass surgery'. Scandanavian Journal of Gastroenterology, . [Details]
Neff KJ, Frankel AH, Tam FW, Sadlier DM, Godson C, le Roux CW. (2013) 'The effect of bariatric surgery on renal function and disease: a focus on outcomes and inflammation'. Nephrology Dialysis Transplantation, . [Details]
Pournaras DJ, le Roux CW. (2013) 'Preventing type 2 diabetes, CVD, and mortality: surgical versus non-surgical weight loss strategies'. Current Atherosclerosis Reports, . [Details]
Lucey H, Elliot J, Higgins DF, Neff KJ, le Roux CW. (2013) 'Diabetic kidney disease after metabolic surgery'. Irish Journal of Medical Science, 182 (11):S490. [Details]
Elliott JA, Patel VM;Kirresh A;Ashrafian H;Le Roux CW;Olbers T;Athanasiou T;Zacharakis E (2013) 'Fast-track laparoscopic bariatric surgery: a systematic review'. Updates in Surgery, 65 (2):85-94. [DOI] [Details]
Papamargaritis, D,le Roux, CW,Sioka, E,Koukoulis, G,Tzovaras, G,Zacharoulis, D (2013) 'Changes in gut hormone profile and glucose homeostasis after laparoscopic sleeve gastrectomy'. Surgery for Obesity and Related Diseases, 9 :192-201. [DOI] [Details]
Iesari, S,le Roux, CW,De Gaetano, A,Manco, M,Nanni, G,Mingrone, G (2013) 'Twenty-Four Hour Energy Expenditure and Skeletal Muscle Gene Expression Changes After Bariatric Surgery'. Journal of Clinical Endocrinology and Metabolism, 98 :321-327. [DOI] [Details]
Seyfried, F,Li, JV,Miras, AD,Cluny, NL,Lannoo, M,Fenske, WK,Sharkey, KA,Nicholson, JK,le Roux, CW,Holmes, E (2013) 'Urinary Phenotyping Indicates Weight Loss-Independent Metabolic Effects of Roux-en-Y Gastric Bypass in Mice'. Journal of Proteome Research, 12 :1245-1253. [DOI] [Details]
Neff, KJH,le Roux, CW (2013) 'Bariatric surgery: a best practice article'. Journal of Clinical Pathology - Clinical Molecular Pathology, 66 :90-98. [DOI] [Details]
Werling, M. and Fändriks, L. and Björklund, P. and Maleckas, A. and Brandberg, J. and Lönroth, H. and Le Roux, C.W. and Olbers, T. (2013) 'Long-term results of a randomized clinical trial comparing Roux-en-y gastric bypass with vertical banded gastroplasty'. British Journal of Surgery, 100 (2):222-230. Available Online [Details]
Neff, K.J. and Olbers, T. and le Roux, C.W. (2013) 'Bariatric surgery: The challenges with candidate selection, individualizing treatment and clinical outcomes'. BMC Medicine, 11 (1). Available Online [Details]
Neff, K.J. and Le Roux, C.W. (2013) 'Incretins: New targets for the prevention of diabetes and obesity'. Clinical Lipidology, 8 (1):109-121. Available Online [Details]
Vincent, R.P. and Omar, S. and Elnenaei, M.O. and Goo, C.H. and Salota, R. and Wu, P. and Delaney, H.L. and Le Roux, C.W. (2013) 'Adherence to the national institute of clinical excellence guidance on parenteral nutrition screening is not enough to improve outcomes'. Clinical Nutrition, 32 (1):73-76. Available Online [Details]
Neff, K.J.H. and Le Roux, C.W. (2013) 'Bariatric surgery: A best practice article'. Journal of Clinical Pathology, 66 (2):90-98. Available Online [Details]
Werling, M. and Olbers, T. and Fändriks, L. and Bueter, M. and Lönroth, H. and Stenlöf, K. and le Roux, C.W. (2013) 'Increased Postprandial Energy Expenditure May Explain Superior Long Term Weight Loss after Roux-en-Y Gastric Bypass Compared to Vertical Banded Gastroplasty'. PLoS ONE, 8 (4). Available Online [Details]
Papamargaritis, D. and Miras, A.D. and le Roux, C.W. (2013) 'Influence of diabetes surgery on gut hormones and incretins [Influencia de cirugía diabetes sobre hormonas intestinales e incretinas]'. Nutricion Hospitalaria, 28 (SUPPL2):95-103. Available Online [Details]
Chuah, L.L. and Papamargaritis, D. and Pillai, D. and Krishnamoorthy, A. and le Roux, C.W. (2013) 'Morbidity and mortality of diabetes with surgery [Morbi-mortalidad en pacientes diabéticos tipo 2 tras cirugía electiva]'. Nutricion Hospitalaria, 28 (SUPPL2):47-52. Available Online [Details]
Chuah, L.L. and le Roux, C.W. (2013) 'Management of patients with type 2 diabetes before and after bariatric surgery: Evolution and microvascular complications [Manejo de pacientes con diabetes tipo 2 antes y después de la cirugía bariátrica: Evolución y complicaciones microvasculares]'. Nutricion Hospitalaria, 28 (SUPPL2):17-22. Available Online [Details]
Neff, K.J. and O'Shea, D. and le Roux, C.W. (2013) 'Glucagon like peptide-1 (GLP-1) dynamics following bariatric surgery: A signpost to a new frontier'. Current Diabetes Reviews, 9 (2):93-101. Available Online [Details]
Elliott, J.A. and Patel, V.M. and Kirresh, A. and Ashrafian, H. and Le Roux, C.W. and Olbers, T. and Athanasiou, T. and Zacharakis, E. (2013) 'Fast-track laparoscopic bariatric surgery: A systematic review'. Updates in Surgery, 65 (2):85-94. Available Online [Details]
Fenske, W.K. and Dubb, S. and Bueter, M. and Seyfried, F. and Patel, K. and Tam, F.W.K. and Frankel, A.H. and Le Roux, C.W. (2013) 'Effect of bariatric surgery-induced weight loss on renal and systemic inflammation and blood pressure: A 12-month prospective study'. Surgery for Obesity and Related Diseases, 9 (4):559-568. Available Online [Details]
Pournaras, D.J. and Le Roux, C.W. (2013) 'Are bile acids the new gut hormones? Lessons from weight loss surgery models'. Endocrinology, 154 (7):2255-2256. Available Online [Details]
Osto, M. and Abegg, K. and Bueter, M. and le Roux, C.W. and Cani, P.D. and Lutz, T.A. (2013) 'Roux-en-Y gastric bypass surgery in rats alters gut microbiota profile along the intestine'. Physiology and Behavior, 119 :92-96. Available Online [Details]
De Jonge, C. and Rensen, S.S. and Verdam, F.J. and Vincent, R.P. and Bloom, S.R. and Buurman, W.A. and Le Roux, C.W. and Schaper, N.C. and Bouvy, N.D. and Greve, J.W.M. (2013) 'Endoscopic duodenal-jejunal bypass liner rapidly improves type 2 diabetes'. Obesity Surgery, 23 (9):1354-1360. Available Online [Details]
Miras, A.D. and Le Roux, C.W. (2013) 'Mechanisms underlying weight loss after bariatric surgery'. Nature Reviews Gastroenterology and Hepatology, 10 (10):575-584. Available Online [Details]
Werling, M. and Vincent, R.P. and Cross, G.F. and Marschall, H.-U. and Fändriks, L. and Lönroth, H. and Taylor, D.R. and Alaghband-Zadeh, J. and Olbers, T. and Le Roux, C.W. (2013) 'Enhanced fasting and post-prandial plasma bile acid responses after Roux-en-Y gastric bypass surgery'. Scandinavian Journal of Gastroenterology, 48 (11):1257-1264. Available Online [Details]
Seyfried, F. and Miras, A.D. and Bueter, M. and Prechtl, C.G. and Spector, A.C. and Le Roux, C.W. (2013) 'Effects of preoperative exposure to a high-fat versus a low-fat diet on ingestive behavior after gastric bypass surgery in rats'. Surgical Endoscopy and Other Interventional Techniques, 27 (11):4192-4201. Available Online [Details]
Cohen, R. and le Roux, C.W. and Papamargaritis, D. and Salles, J.E. and Petry, T. and Correa, J.L. and Pournaras, D.J. and Galvao Neto, M. and Martins, B. and Sakai, P. and Schiavon, C.A. and Sorli, C. (2013) 'Role of proximal gut exclusion from food on glucose homeostasis in patients with Type 2 diabetes'. Diabetic Medicine, 30 (12):1482-1486. Available Online [Details]
Vincent, R.P. and Omar, S. and Ghozlan, S. and Taylor, D.R. and Cross, G. and Sherwood, R.A. and Fandriks, L. and Olbers, T. and Werling, M. and Alaghband-Zadeh, J. and le Roux, C.W. (2013) 'Higher circulating bile acid concentrations in obese patients with type 2 diabetes'. Annals of Clinical Biochemistry, 50 (4):360-364. Available Online [Details]
Sam AH, Busbridge M, Amin A, Webber L, White D, Franks S, Martin NM, Sleeth M, Ismail NA, Daud NM, Papamargaritis D, Le Roux CW, Chapman RS, Frost G, Bloom SR, Murphy KG. (2013) 'Hepcidin levels in diabetes mellitus and polycystic ovary syndrome'. Diabetic Medicine, . [DOI] [Details]
Neff KJ, le Roux CW. (2013) 'Bariatric Surgery: The Indications in Metabolic Disease'. Digestive Surgery, . [Details]
Scholtz S, Miras AD, Chhina N, Prechtl CG, Sleeth ML, Daud NM, Ismail NA, Durighel G, Ahmed AR, Olbers T, Vincent RP, Alaghband-Zadeh J, Ghatei MA, Waldman AD, Frost GS, Bell JD, le Roux CW, Goldstone AP. (2013) 'Obese patients after gastric bypass surgery have lower brain-hedonic responses to food than after gastric banding'. Gut, . [DOI] [Details]
Tako AA, Kotiadis K, Vasilakis C, Miras A, le Roux CW (2013) 'Improving patient waiting times: a simulation study of an obesity care service'. Bmj Quality & Safety, . [DOI] [Details]
Neff KJ, Frankel AH, Tam FW, Sadlier DM, Godson C, le Roux CW. (2013) 'The effect of bariatric surgery on renal function and disease: a focus on outcomes and inflammation'. Nephrology Dialysis Transplantation, . [DOI] [Details]
Pournaras DJ, le Roux CW (2013) 'Preventing type 2 diabetes, CVD, and mortality: surgical versus non-surgical weight loss strategies'. Current Atherosclerosis Reports, . [DOI] [Details]
Miras AD, le Roux CW. (2013) 'Can medical therapy mimic the clinical efficacy or physiological effects of bariatric surgery?'. International Journal of Obesity, . [DOI] [Details]
Fenske, W.K. and Pournaras, D.J. and Aasheim, E.T. and Miras, A.D. and Scopinaro, N. and Scholtz, S. and Le Roux, C.W. (2012) 'Can a protocol for glycaemic control improve type 2 diabetes outcomes after gastric bypass?'. Obesity Surgery, 22 (1):90-96. Available Online [Details]
Papamargaritis, D,Panteliou, E,Miras, AD,le Roux, CW (2012) 'Mechanisms of Weight Loss, Diabetes Control and Changes in Food Choices After Gastrointestinal Surgery'. Current Atherosclerosis Reports, 14 :616-623. [DOI] [Details]
Miras, AD,Jackson, RN,Jackson, SN,Goldstone, AP,Olbers, T,Hackenberg, T,Spector, AC,le Roux, CW (2012) 'Gastric bypass surgery for obesity decreases the reward value of a sweet-fat stimulus as assessed in a progressive ratio task'. American Journal of Clinical Nutrition, 96 :467-473. [DOI] [Details]
Pournaras, DJ,Glicksman, C,Vincent, RP,Kuganolipava, S,Alaghband-Zadeh, J,Mahon, D,Bekker, JHR,Ghatei, MA,Bloom, SR,Walters, JRF,Welbourn, R,le Roux, CW (2012) 'The Role of Bile After Roux-en-Y Gastric Bypass in Promoting Weight Loss and Improving Glycaemic Control'. Journal of Endocrinology, 153 :3613-3619. [DOI] [Details]
Hankir, M,Bueter, M,Gsell, W,Seyfried, F,Khalil, M,Smith, KL,Bloom, SR,Bell, JD,le Roux, CW (2012) 'Increased Energy Expenditure in Gastric Bypass Rats Is Not Caused by Activated Brown Adipose Tissue'. Obesity Facts, 5 :349-358. [DOI] [Details]
Parker, H.E. and Wallis, K. and Le Roux, C.W. and Wong, K.Y. and Reimann, F. and Gribble, F.M. (2012) 'Molecular mechanisms underlying bile acid-stimulated glucagon-like peptide-1 secretion'. British Journal of Pharmacology, 165 (2):414-423. Available Online [Details]
Pournaras, D.J. and Aasheim, E.T. and Søvik, T.T. and Andrews, R. and Mahon, D. and Welbourn, R. and Olbers, T. and Le Roux, C.W. (2012) 'Effect of the definition of type II diabetes remission in the evaluation of bariatric surgery for metabolic disorders'. British Journal of Surgery, 99 (1):100-103. Available Online [Details]
Fenske, W.K. and Bueter, M. and Miras, A.D. and Ghatei, M.A. and Bloom, S.R. and Le Roux, C.W. (2012) 'Exogenous peptide YY3-36 and Exendin-4 further decrease food intake, whereas octreotide increases food intake in rats after Roux-en-Y gastric bypass'. International Journal of Obesity, 36 (3):379-384. Available Online [Details]
Kennedy, E. and Alberti, G. and Le Roux, C. (2012) 'Bariatric surgery: A European perspective'. European Diabetes Nursing, 9 (1):22-25. Available Online [Details]
Ashrafian, H. and Le Roux, C.W. and Rowland, S.P. and Ali, M. and Cummin, A.R. and Darzi, A. and Athanasiou, T. (2012) 'Metabolic surgery and obstructive sleep apnoea: The protective effects of bariatric procedures'. Thorax, 67 (5):442-449. Available Online [Details]
Hankir, M. and Bueter, M. and Gsell, W. and Seyfried, F. and Khalil, M. and Smith, K.L. and Bloom, S.R. and Bell, J.D. and Le Roux, C.W. (2012) 'Increased energy expenditure in gastric bypass rats is not caused by activated brown adipose tissue'. Obesity Facts, 5 (3):349-358. Available Online [Details]
Dixon, J.B. and Le Roux, C.W. and Rubino, F. and Zimmet, P. (2012) 'Bariatric surgery for type 2 diabetes'. The Lancet, 379 (9833):2300-2311. Available Online [Details]
Seyfried, F. and Lannoo, M. and Gsell, W. and Tremoleda, J.L. and Bueter, M. and Olbers, T. and Jurowich, C. and Germer, C.-T. and Le Roux, C.W. (2012) 'Roux-en-Y gastric bypass in mice - Surgical technique and characterisation'. Obesity Surgery, 22 (7):1117-1125. Available Online [Details]
Pournaras, D.J. and Aasheim, E.T. and Bueter, M. and Ahmed, A.R. and Welbourn, R. and Olbers, T. and Le Roux, C.W. (2012) 'Effect of bypassing the proximal gut on gut hormones involved with glycemic control and weight loss'. Surgery for Obesity and Related Diseases, 8 (4):371-374. Available Online [Details]
Pournaras, D.J. and Glicksman, C. and Vincent, R.P. and Kuganolipava, S. and Alaghband-Zadeh, J. and Mahon, D. and Bekker, J.H.R. and Ghatei, M.A. and Bloom, S.R. and Walters, J.R.F. and Welbourn, R. and Le Roux, C.W. (2012) 'The role of bile after Roux-en-Y gastric bypass in promoting weight loss and improving glycaemic control'. Endocrinology, 153 (8):3613-3619. Available Online [Details]
Miras, A.D. and Jackson, R.N. and Jackson, S.N. and Goldstone, A.P. and Olbers, T. and Hackenberg, T. and Spector, A.C. and Le Roux, C.W. (2012) 'Gastric bypass surgery for obesity decreases the reward value of a sweet-fat stimulus as assessed in a progressive ratio task'. American Journal of Clinical Nutrition, 96 (3):467-473. Available Online [Details]
Roberts, R.E. and Zhao, M. and Whitelaw, B.C. and Ramage, J. and Diaz-Cano, S. and Le Roux, C.W. and Quaglia, A. and Huang, G.C. and Aylwin, S.J.B. (2012) 'GLP-1 and glucagon secretion from a pancreatic neuroendocrine tumor causing diabetes and hyperinsulinemic hypoglycemia'. Journal of Clinical Endocrinology and Metabolism, 97 (9):3039-3045. Available Online [Details]
Michalakis, K. and Le Roux, C. (2012) 'Gut hormones and leptin: Impact on energy control and changes after bariatric surgerywhat the future holds'. Obesity Surgery, 22 (10):1648-1657. Available Online [Details]
Ratner, C. and Ettrup, A. and Bueter, M. and Haahr, M.E. and Compan, V. and Le Roux, C.W. and Levin, B. and Hansen, H.H. and Knudsen, G.M. (2012) 'Cerebral markers of the serotonergic system in rat models of obesity and after Roux-en-Y gastric bypass'. Obesity, 20 (10):2133-2141. Available Online [Details]
Miras, A.D. and Chuah, L.L. and Lascaratos, G. and Faruq, S. and Mohite, A.A. and Shah, P.R. and Gill, M. and Jackson, S.N. and Johnston, D.G. and Olbers, T. and Le Roux, C.W. (2012) 'Bariatric surgery does not exacerbate and may be beneficial for the microvascular complications of type 2 diabetes'. Diabetes Care, 35 (12). Available Online [Details]
Papamargaritis, D. and Panteliou, E. and Miras, A.D. and Le Roux, C.W. (2012) 'Mechanisms of weight loss, diabetes control and changes in food choices after gastrointestinal surgery'. Current Atherosclerosis Reports, 14 (6):616-623. Available Online [Details]
Patle, R. and Dubb, S. and Alaghband-Zadeh, J. and Sherwood, R.A. and Tam, F. and Frankel, A. and Moniz, C. and Bueter, M. and Vincent, R.P. and Le Roux, C.W. (2012) 'Improved blood pressure, nitric oxide and asymmetric dimethylarginine are independent after bariatric surgery'. Annals of Clinical Biochemistry, 49 (6):589-594. Available Online [Details]
Atogo-Asse, F.-E. and Vincent, R.P. and Hughes, S.A. and Auzinger, G. and Le Roux, C.W. and Wendon, J. and Bernal, W. (2012) 'High density lipoprotein in patients with liver failure; Relation to sepsis, adrenal function and outcome of illness'. Liver International, 32 (1):128-136. Available Online [Details]
Li, J.V. and Reshat, R. and Wu, Q. and Ashrafian, H. and Bueter, M. and le Roux, C.W. and Darzi, C.W.L.R. and Athanasiou, T. and Marchesi, J.R. and Nicholson, J.K. and Holmes, E. and Gooderham, N.J. (2011) 'Experimental bariatric surgery in rats generates a cytotoxic chemical environment in the gut contents'. Frontiers in Microbiology, 2 (SEP). Available Online [Details]
Dixon, A.F.R. and Le Roux, C.W. and Ghatei, M.A. and Bloom, S.R. and McGee, T.L. and Dixon, J.B. (2011) 'Pancreatic polypeptide meal response may predict gastric band-induced weight loss'. Obesity Surgery, 21 (12):1906-1913. Available Online [Details]
Bueter, M. and Miras, A.D. and Chichger, H. and Fenske, W. and Ghatei, M.A. and Bloom, S.R. and Unwin, R.J. and Lutz, T.A. and Spector, A.C. and Le Roux, C.W. (2011) 'Alterations of sucrose preference after Roux-en-Y gastric bypass'. Physiology and Behavior, 104 (5):709-721. Available Online [Details]
Haslam, D. and Le Roux, C. (2011) 'Efficiency. A heavyweight answer to obesity'. The Health service journal, 121 (6276):32-33. Available Online [Details]
Elnenaei, M.O. and Alaghband-Zadeh, J. and Sherwood, R. and Awara, M.A. and Moniz, C. and Le Roux, C.W. (2011) 'Leptin and insulin growth factor 1: Diagnostic markers of the refeeding syndrome and mortality'. British Journal of Nutrition, 106 (6):906-912. Available Online [Details]
Li, J.V. and Ashrafian, H. and Bueter, M. and Kinross, J. and Sands, C. and Le Roux, C.W. and Bloom, S.R. and Darzi, A. and Athanasiou, T. and Marchesi, J.R. and Nicholson, J.K. and Holmes, E. (2011) 'Metabolic surgery profoundly influences gut microbial - Host metabolic cross-talk'. Gut, 60 (9):1214-1223. Available Online [Details]
Hall, J.I. and Vora, N. and Langworthy, R. and Stock, S. and Momin, A. and Sherwood, R.A. and le Roux, C.W. and Alaghband-Zadeh, J. (2011) 'Leptin/adiponectin ratio in patients with coronary heart disease: Comparing subjects with and without metabolic syndrome'. Annals of Clinical Biochemistry, 48 (4):327-331. Available Online [Details]
Seyfried, F. and Le Roux, C.W. and Bueter, M. (2011) 'Lessons learned from gastric bypass operations in rats'. Obesity Facts, 4 (SUPPL. 1):3-12. Available Online [Details]
Beckman, L.M. and Beckman, T.R. and Sibley, S.D. and Thomas, W. and Ikramuddin, S. and Kellogg, T.A. and Ghatei, M.A. and Bloom, S.R. and Le Roux, C.W. and Earthman, C.P. (2011) 'Changes in gastrointestinal hormones and leptin after Roux-en-Y gastric bypass surgery'. Journal of Parenteral and Enteral Nutrition, 35 (2):169-180. Available Online [Details]
Ashrafian, H. and Athanasiou, T. and Le Roux, C.W. (2011) 'Heart remodelling and obesity: The complexities and variation of cardiac geometry'. Heart, 97 (3):171-172. Available Online [Details]
Roberts, R.E. and Glicksman, C. and Alaghband-Zadeh, J. and Sherwood, R.A. and Akuji, N. and Le Roux, C.W. (2011) 'The relationship between postprandial bile acid concentration, GLP-1, PYY and ghrelin'. Clinical Endocrinology, 74 (1):67-72. Available Online [Details]
Bueter, M. and Ashrafian, H. and Frankel, A.H. and Tam, F.W.K. and Unwin, R.J. and Le Roux, C.W. (2011) 'Sodium and water handling after gastric bypass surgery in a rat model'. Surgery for Obesity and Related Diseases, 7 (1):68-73. Available Online [Details]
Pournaras, D.J. and Osborne, A. and Hawkins, S.C. and Vincent, R.P. and Mahon, D. and Ewings, P. and Ghatei, M.A. and Bloom, S.R. and Welbourn, R. and Le Roux, C.W. (2010) 'Remission of type 2 diabetes after gastric bypass and banding: Mechanisms and 2 year outcomes'. Annals of Surgery, 252 (6):966-971. Available Online [Details]
Bueter, M. and Dubb, S.S. and Gill, A. and Joannou, L. and Ahmed, A. and Frankel, A.H. and Tam, F.W.K. and Le Roux, C.W. (2010) 'Renal cytokines improve early after bariatric surgery'. British Journal of Surgery, 97 (12):1838-1844. Available Online [Details]
Pournaras, D.J. and Le Roux, C.W. (2010) 'Ghrelin and metabolic surgery'. International Journal of Peptides, 2010 . Available Online [Details]
Glicksman, C. and Pournaras, D.J. and Wright, M. and Roberts, R. and Mahon, D. and Welbourn, R. and Sherwood, R. and Alaghband-Zadeh, J. and Le Roux, C.W. (2010) 'Postprandial plasma bile acid responses in normal weight and obese subjects'. Annals of Clinical Biochemistry, 47 (5):482-484. Available Online [Details]
Elnenaei, M.O. and Musto, R. and Alaghband-Zadeh, J. and Moniz, C. and Le Roux, C.W. (2010) 'Postprandial bone turnover is independent of calories above 250 kcal'. Annals of Clinical Biochemistry, 47 (4):318-320. Available Online [Details]
Le Roux, C.W. and Borg, C. and Wallis, K. and Vincent, R.P. and Bueter, M. and Goodlad, R. and Ghatei, M.A. and Patel, A. and Bloom, S.R. and Aylwin, S.J.B. (2010) 'Gut hypertrophy after gastric bypass is associated with increased glucagon-like peptide 2 and intestinal crypt cell proliferation'. Annals of Surgery, 252 (1):50-56. Available Online [Details]
Le Roux, C.W. and Pournaras, D.J. (2010) 'Metabolic surgery: Nutritional outcomes and health benefits'. CAB Reviews: Perspectives in Agriculture, Veterinary Science, Nutrition and Natural Resources, 5 :1-6. Available Online [Details]
Scholtz, S. and Le Roux, C. and Balen, A.H. (2010) 'The role of bariatric surgery in the management of female fertility'. Human Fertility, 13 (2):67-71. Available Online [Details]
Bueter, M. and Löwenstein, C. and Olbers, T. and Wang, M. and Cluny, N.L. and Bloom, S.R. and Sharkey, K.A. and Lutz, T.A. and le Roux, C.W. (2010) 'Gastric Bypass Increases Energy Expenditure in Rats'. Gastroenterology, 138 (5):1845-1853.e1. Available Online [Details]
Bueter, M. and Löwenstein, C. and Ashrafian, H. and Hillebrand, J. and Bloom, S.R. and Olbers, T. and Lutz, T. and Le Roux, C.W. (2010) 'Vagal sparing surgical technique but not stoma size affects body weight loss in rodent model of gastric bypass'. Obesity Surgery, 20 (5):616-622. Available Online [Details]
Bueter, M. and Thalheimer, A. and Le Roux, C.W. and Wierlemann, A. and Seyfried, F. and Fein, M. (2010) 'Upper gastrointestinal investigations before gastric banding'. Surgical Endoscopy and Other Interventional Techniques, 24 (5):1025-1030. Available Online [Details]
Vincent, R.P. and Goo, C.H. and Wu, P.F. and Delaney, H.L. and le Roux, C.W. (2010) 'Influence of adherence to the national guidance on nutrition screening and dietitian referral on clinical outcomes of those requiring parenteral nutrition'. Journal of Human Nutrition and Dietetics, 23 (2):190-193. Available Online [Details]
Sathyapalan, T. and Cho, L. and Kilpatrick, E.S. and Le Roux, C.W. and Coady, A.-M. and Atkin, S.L. (2010) 'Effect of rimonabant and metformin on glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 in obese women with polycystic ovary syndrome'. Clinical Endocrinology, 72 (3):423-425. Available Online [Details]
Alexandraki, K.I. and Kaltsas, G.A. and Le Roux, C.W. and Fassnacht, M. and Ajodha, S. and Christ-Crain, M. and Akker, S.A. and Drake, W.M. and Edwards, R. and Allolio, B. and Grossman, A.B. (2010) 'Assessment of serum-free cortisol levels in patients with adrenocortical carcinoma treated with mitotane: A pilot study'. Clinical Endocrinology, 72 (3):305-311. Available Online [Details]
Miras, A.D. and Le Roux, C.W. (2010) 'Bariatric surgery and taste: Novel mechanisms of weight loss'. Current Opinion in Gastroenterology, 26 (2):140-145. Available Online [Details]
Kokkinos, A. and Le Roux, C.W. and Alexiadou, K. and Tentolouris, N. and Vincent, R.P. and Kyriaki, D. and Perrea, D. and Ghatei, M.A. and Bloom, S.R. and Katsilambros, N. (2010) 'Eating slowly increases the postprandial response of the anorexigenic gut hormones, peptide YY and glucagon-like peptide-1'. Journal of Clinical Endocrinology and Metabolism, 95 (1):333-337. Available Online [Details]
Pournaras, D.J. and Osborne, A. and Hawkins, S.C. and Mahon, D. and Ghatei, M.A. and Bloom, S.R. and Welbourn, R. and Le Roux, C.W. (2010) 'The gut hormone response following roux-en-Y gastric bypass: Cross-sectional and prospective study'. Obesity Surgery, 20 (1):56-60. Available Online [Details]
Pournaras, D.-J. and Le Roux, C.-W. (2009) 'The effect of bariatric surgery on gut hormones that alter appetite'. Diabetes and Metabolism, 35 (6 PART II):508-512. Available Online [Details]
Bueter, M. and Ashrafian, H. and Le Roux, C.W. (2009) 'Mechanisms of weight loss after gastric bypass and gastric banding'. Obesity Facts, 2 (5):325-331. Available Online [Details]
Vincent, R.P. and Etogo-Asse, F.E. and Dew, T. and Bernal, W. and Alaghband-Zadeh, J. and Le Roux, C.W. (2009) 'Serum total cortisol and free cortisol index give different information regarding the hypothalamus-pituitary-adrenal axis reserve in patients with liver impairment'. Annals of Clinical Biochemistry, 46 (6):505-507. Available Online [Details]
Walters, J.R.F. and Tasleem, A.M. and Omer, O.S. and Brydon, W.G. and Dew, T. and le Roux, C.W. (2009) 'A New Mechanism for Bile Acid Diarrhea: Defective Feedback Inhibition of Bile Acid Biosynthesis'. Clinical Gastroenterology and Hepatology, 7 (11):1189-1194. Available Online [Details]
Vincent, R.P. and Aylwin, S.J.B. and Le Roux, C.W. (2009) 'When the brakes came off: re-feeding oedema after deflation of a gastric band: A case report'. Obesity Surgery, 19 (10):1468-1470. Available Online [Details]
Pournaras, D.J. and Le Roux, C.W. (2009) 'Obesity, gut hormones, and bariatric surgery'. World Journal of Surgery, 33 (10):1983-1988. Available Online [Details]
Bueter, M. and Ahmed, A. and Ashrafian, H. and le Roux, C.W. (2009) 'Bariatric surgery and hypertension'. Surgery for Obesity and Related Diseases, 5 (5):615-620. Available Online [Details]
Pournaras, D.J. and Le Roux, C.W. (2009) 'After bariatric surgery, what vitamins should be measured and what supplements should be given?'. Clinical Endocrinology, 71 (3):322-325. Available Online [Details]
Bueter, M. and Le Roux, C.W. (2009) 'Sir David Cuthbertson Medal Lecture Bariatric surgery as a model to study appetite control'. Proceedings of the Nutrition Society, 68 (3):227-233. Available Online [Details]
Ashrafian, H. and le Roux, C.W. (2009) 'Metabolic surgery and gut hormones - A review of bariatric entero-humoral modulation'. Physiology and Behavior, 97 (5):620-631. Available Online [Details]
Ashrafian, H. and Le Roux, C.W. and Darzi, A. and Athanasiou, T. (2008) 'Effects of bariatric surgery on cardiovascular function'. Circulation, 118 (20):2091-2102. Available Online [Details]
Murray, C.D.R. and Le Roux, C.W. and Emmanuel, A.V. and Halket, J.M. and Przyborowska, A.M. and Kamm, M.A. and Murray-Lyon, I.M. (2008) 'The effect of Khat (Catha edulis) as an appetite suppressant is independent of ghrelin and PYY secretion'. Appetite, 51 (3):747-750. Available Online [Details]
Vincent, R.P. and Le Roux, C.W. (2008) 'Changes in gut hormones after bariatric surgery'. Clinical Endocrinology, 69 (2):173-179. Available Online [Details]
Vincent, R.P. and Le Roux, C.W. (2008) 'The satiety hormone peptide YY as a regulator of appetite'. Journal of Clinical Pathology, 61 (5):548-552. Available Online [Details]
Vincent, R.P. and Ashrafian, H. and le Roux, C.W. (2008) 'Mechanisms of disease: The role of gastrointestinal hormones in appetite and obesity'. Nature Clinical Practice Gastroenterology and Hepatology, 5 (5):268-277. Available Online [Details]
Le Roux, C.W. and Borg, C.M. and Murphy, K.G. and Vincent, R.P. and Ghatei, M.A. and Bloom, S.R. (2008) 'Supraphysiological doses of intravenous PYY3-36 cause nausea, but no additional reduction in food intake'. Annals of Clinical Biochemistry, 45 (1):93-95. Available Online [Details]
Moran, L.J. and Noakes, M. and Clifton, P.M. and Wittert, G.A. and Le Roux, C.W. and Ghatei, M.A. and Bloom, S.R. and Norman, R.J. (2007) 'Postprandial ghrelin, cholecystokinin, peptide YY, and appetite before and after weight loss in overweight women with and without polycystic ovary syndrome'. American Journal of Clinical Nutrition, 86 (6):1603-1610. Available Online [Details]
Vincent, R.P. and Le Roux, C.W. (2007) 'New agents in development for the management of obesity'. International Journal of Clinical Practice, 61 (12):2103-2112. Available Online [Details]
Le Roux, C.W. and Welbourn, R. and Werling, M. and Osborne, A. and Kokkinos, A. and Laurenius, A. and Lönroth, H. and Fändriks, L. and Ghatei, M.A. and Bloom, S.R. and Olbers, T. (2007) 'Gut hormones as mediators of appetite and weight loss after Roux-en-Y gastric bypass'. Annals of Surgery, 246 (5):780-785. Available Online [Details]
Vasilakopoulou, A. and Le Roux, C.W. (2007) 'Could a virus contribute to weight gain?'. International Journal of Obesity, 31 (9):1350-1356. Available Online [Details]
Germain, N. and Galusca, B. and Le Roux, C.W. and Bossu, C. and Ghatei, M.A. and Lang, F. and Bloom, S.R. and Estour, B. (2007) 'Constitutional thinness and lean anorexia nervosa display opposite concentrations of peptide YY, glucagon-like peptide 1, ghrelin, and leptin'. American Journal of Clinical Nutrition, 85 (4):967-971. Available Online [Details]
Vincent, R.P. and Le Roux, C.W. (2006) 'Peptide YY, food intake and obesity'. CPD Bulletin Clinical Biochemistry, 7 (3):116-121. Available Online [Details]
Batterham, R.L. and Heffron, H. and Kapoor, S. and Chivers, J.E. and Chandarana, K. and Herzog, H. and Le Roux, C.W. and Thomas, E.L. and Bell, J.D. and Withers, D.J. (2006) 'Critical role for peptide YY in protein-mediated satiation and body-weight regulation'. Cell Metabolism, 4 (3):223-233. Available Online [Details]
Murray, C.D. and le Roux, C.W. and Gouveia, C. and Bassett, P. and Ghatei, M.A. and Bloom, S.R. and Emmanuel, A.V. and Gabe, S.M. (2006) 'The effect of different macronutrient infusions on appetite, ghrelin and peptide YY in parenterally fed patients'. Clinical Nutrition, 25 (4):626-633. Available Online [Details]
Borg, C.M. and Le Roux, C.W. and Ghatei, M.A. and Bloom, S.R. and Patel, A.G. and Aylwin, S.J.B. (2006) 'Progressive rise in gut hormone levels after Roux-en-Y gastric bypass suggests gut adaptation and explains altered satiety'. British Journal of Surgery, 93 (2):210-215. Available Online [Details]
Le Roux, C.W. and Batterham, R.L. and Aylwin, S.J.B. and Patterson, M. and Borg, C.M. and Wynne, K.J. and Kent, A. and Vincent, R.P. and Gardiner, J. and Ghatei, M.A. and Bloom, S.R. (2006) 'Attenuated peptide YY release in obese subjects is associated with reduced satiety'. Endocrinology, 147 (1):3-8. Available Online [Details]
Le Roux, C.W. and Aylwin, S.J.B. and Batterham, R.L. and Borg, C.M. and Coyle, F. and Prasad, V. and Shurey, S. and Ghatei, M.A. and Patel, A.G. and Bloom, S.R. (2006) 'Gut hormone profiles following bariatric surgery favor an anorectic state, facilitate weight loss, and improve metabolic parameters'. Annals of Surgery, 243 (1):108-114. Available Online [Details]
Le Roux, C.W. and Neary, N.M. and Halsey, T.J. and Small, C.J. and Martinez-Isla, A.M. and Ghatei, M.A. and Theodorou, N.A. and Bloom, S.R. (2005) 'Ghrelin does not stimulate food intake in patients with surgical procedures involving vagotomy'. Journal of Clinical Endocrinology and Metabolism, 90 (8):4521-4524. Available Online [Details]
Le Roux, C.W. and Bloom, S.R. (2005) 'Peptide YY, appetite and food intake'. Proceedings of the Nutrition Society, 64 (2):213-216. Available Online [Details]
Patterson, M. and Murphy, K.G. and Le Roux, C.W. and Ghatei, M.A. and Bloom, S.R. (2005) 'Characterization of ghrelin-like immunoreactivity in human plasma'. Journal of Clinical Endocrinology and Metabolism, 90 (4):2205-2211. Available Online [Details]
Le Roux, C.W. and Ghatei, M.A. and Gibbs, J.S.R. and Bloom, S.R. (2005) 'The putative satiety hormone PYY is raised in cardiac cachexia associated with primary pulmonary hypertension'. Heart, 91 (2):241-242. Available Online [Details]
Le Roux, C.W. and Patterson, M. and Vincent, R.P. and Hunt, C. and Ghatei, M.A. and Bloom, S.R. (2005) 'Postprandial plasma ghrelin is suppressed proportional to meal calorie content in normal-weight but not obese subjects'. Journal of Clinical Endocrinology and Metabolism, 90 (2):1068-1071. Available Online [Details]
Le Roux, C.W. and Bloom, S.R. (2005) 'Editorial: Why do patients lose weight after Roux-en-Y gastric bypass?'. Journal of Clinical Endocrinology and Metabolism, 90 (1):591-592. Available Online [Details]
Le Roux, C.W. and Wilkinson, S.D. and Pavitt, D.V. and Muller, B.R. and Alaghband-Zadeh, J. (2004) 'A new antiglycolytic agent'. Annals of Clinical Biochemistry, 41 (1):43-46. Available Online [Details]
Cohen, M.A. and Ellis, S.M. and Le Roux, C.W. and Batterham, R.L. and Park, A. and Patterson, M. and Frost, G.S. and Ghatei, M.A. and Bloom, S.R. (2003) 'Oxyntomodulin Suppresses Appetite and Reduces Food Intake in Humans'. Journal of Clinical Endocrinology and Metabolism, 88 (10):4696-4701. Available Online [Details]
Batterham, R.L. and Cohen, M.A. and Ellis, S.M. and Le Roux, C.W. and Withers, D.J. and Frost, G.S. and Ghatei, M.A. and Bloom, S.R. (2003) 'Inhibition of food intake in obese subjects by peptide YY3-36'. New England Journal of Medicine, 349 (10):941-948. Available Online [Details]
Batterham, R.L. and Le Roux, C.W. and Cohen, M.A. and Park, A.J. and Ellis, S.M. and Patterson, M. and Frost, G.S. and Ghatei, M.A. and Bloom, S.R. (2003) 'Pancreatic polypeptide reduces appetite and food intake in humans'. Journal of Clinical Endocrinology and Metabolism, 88 (8):3989-3992. Available Online [Details]
Le Roux, C.W. and Chapman, G.A. and Kong, W.M. and Dhillo, W.S. and Jones, J. and Alaghband-Zadeh, J. (2003) 'Free cortisol index is better than serum total cortisol in determining hypothalamic-pituitary-adrenal status in patients undergoing surgery'. Journal of Clinical Endocrinology and Metabolism, 88 (5):2045-2048. Available Online [Details]
Le Roux, C.W. and Bloom, S.R. (2003) 'Clinical authorization: What is best for the patient?'. Annals of Clinical Biochemistry, 40 (2):113-114. Available Online [Details]
Le Roux, C.W. and Murphy, E. and Seed, M. (2002) 'A retrospective assessment of the effectiveness of fenofibrate 267 mg on high-density lipoprotein cholesterol levels in patients attending a lipid clinic'. Clinical Therapeutics, 24 (7):1154-1160. Available Online [Details]
le Roux, C.W. and Jenkins, P.J. and Chew, S.L. and Camacho-Hübner, C. and Grossman, A.B. and Besser, G.M. and Monson, J.P. (2002) 'Growth hormone replacement does not increase serum prostate-specific antigen in hypopituitary men over 50 years'. European Journal of Endocrinology, 147 (1):59-63. Available Online [Details]
Le Roux, C.W. and Sivakumaran, S. and Alaghband-Zadeh, J. and Dhillo, W. and Kong, W.M. and Wheeler, M.J. (2002) 'Free cortisol index as a surrogate marker for serum free cortisol'. Annals of Clinical Biochemistry, 39 (4):406-408. Available Online [Details]
Le Roux, C.W. and Meeran, K. and Alaghband-Zadeh, J. (2002) 'Is a 0900-h serum cortisol useful prior to a short Synacthen test in outpatient assessment?'. Annals of Clinical Biochemistry, 39 (2):148-150. Available Online [Details]
Dhillo, W.S. and Kong, W.M. and Le Roux, C.W. and Alaghband-Zadeh, J. and Jones, J. and Carter, G. and Mendoza, N. and Meeran, K. and O'Shea, D. (2002) 'Cortisol-binding globulin is important in the interpretation of dynamic tests of the hypothalamic-pituitary-adrenal axis'. European Journal of Endocrinology, 146 (2):231-235. Available Online [Details]
       

Editorial

Elliott JA, le Roux CW (2016) Type 2 diabetes with BMI<30 kg/m(2): Can we predict success of metabolic surgery?. Editorial [DOI] [Details]
Elliott JA, le Roux CW;Ph D FR (2015) How long should we make the biliopancreatic limb during Roux-en-Y gastric bypass?. Editorial [DOI] [Details]
                 

Abstract

Neff, KJ,Prenner, C,Chuah, LL,Godsland, I,le Roux, CW (2013) Bariatric Surgery: A Holistic Assessment of Outcomes. Abstract [Details]
Neff, KJ,Prenner, C,Chuah, LL,Godsland, P,le Roux, CW (2012) Bariatric Surgery and Outcomes in Northern Ireland. Abstract [Details]
       

Reviews

Neff, KJ,Olbers, T,le Roux, CW (2013) Bariatric surgery: the challenges with candidate selection, individualizing treatment and clinical outcomes. Reviews [DOI] [Details]
Neff, KJ,le Roux, CW (2013) Incretins: new targets for the prevention of diabetes and obesity. Reviews [DOI] [Details]
                                                                             

Research

Research Interests

Weight loss after upper gastrointestinal surgery

Weight loss presents a significant and unmet clinical challenge for long-term oesophageal cancer survivors. Our pilot data demonstrate exaggerated post-prandial satiety gut hormone responses after oesophagectomy and we propose that pharmacologic attenuation of this process may be of therapeutic utility.


We hypothesise that exaggerated post-prandial satiety gut hormone responses post-oesophagectomy result in reduced appetitive drive and unintentional weight loss. Consequently, pharmacologic attenuation of this response may result in increased food intake and hence body weight.

 

Aim 1: Post-prandial gut hormone secretion will be prospectively characterized among thirty patients undergoing oesophagectomy.

Aim 2: To determine the role of gut hormones as mediators of appetitive drive after oesophagectomy, we will conduct a randomised, double-blind, placebo-controlled crossover study using a validated behavioural paradigm. Changes in appetitive drive will be compared following administration of octreotide among post-oesophagectomy subjects and matched controls.

Aim 3: To determine the role of gut hormones as mediators of early satiety and food intake post-oesophagectomy, a randomised, double-blind, placebo controlled, crossover study of the effect of single dose octreotide on ad libitum calorie consumption will then be conducted.

Aim 4: We will conduct a randomised, double-blind, placebo-controlled, parallel-group study to assess the effect of octreotide therapy on body weight among disease-free post-oesophagectomy patients with persistent weight loss. Subjects¿ weight, micronutrient levels, body composition, ad libitum calorie intake and QoL will be assessed at the start of the study, after four weeks of intervention and after a four week run-out period. In addition, treatment adherence and adverse events will be documented to determine the feasibility and safety of octreotide therapy in this cohort.

Diabetic kidney disease and metabolic surgery

Diabetic kidney disease (DKD) is the leading cause of renal failure and death from cardiovascular disease. Unfortunately, current therapies are not very effective. Our recent data show that Roux-en-Y gastric bypass (RYGB) surgery can attenuate DKD in obese humans. Thus understanding the underlying mechanisms of such reversal can lead to the development of novel therapies and the identification of key biomarkers. 

Our objectives will be to investigate:

Aim 1: Physiological mechanisms associated with reversal of DKD after RYGB, using an established RYGB rat model in Zucker diabetic fatty (ZDF) rats. 

Aim 2: Molecular mechanisms associated with reversal of DKD after RYGB, by defining alterations in renal gene expression profiles in ZDF rats after RYGB. 

Aim 3: Identifying innovative biomarkers of DKD regression/progression, by using samples from an established randomized controlled trial comparing RYGB to best medical care in patients with DKD.

Impact: The proposed programme addresses an urgent and fundamental question: 'What are the potential mechanisms underlying the reversal of DKD and how can this knowledge be exploited for therapeutic gain?'.  Our findings have the potential to lead to replacement or reduction of the risks of surgery with targeted medical treatments that could effectively impact more patients with DKD. We will achieve our aims by working within an established international consortium while also collaborating with the EKF Diagnostics, while training the next generation of scientists in this exciting space.



UCD Medicine Research Centre: Diabetes Complications 

Research Projects

Sponsor : Food for Health Ireland - FHI2 UCD
Title : FHI-2
Start Date / End Date : 03-MAR-15 / 31-AUG-18
Sponsor : Health Research Board (HRB)
Title : Attenuation of Exaggerated Post-Prandial Gut Hormone Response: A Novel Therapeutic Strategy for the Treatment of Excessive Weight Loss Among Disease-Free Post-Oesophagectomy Patients
Start Date / End Date : 07-JUL-15 / 06-JUL-18
Sponsor : University College Dublin (UCD)
Title : Start-up grant
Start Date / End Date : 01-JAN-13 / 31-DEC-17
Sponsor : University College Dublin Foundation Ltd.
Title : The Effect of GLP-1 on inflammation in Obesity
Start Date / End Date : 01-MAR-13 / 29-FEB-16
Sponsor : University College Dublin (UCD)
Title : UCD Obesity Research fund
Start Date / End Date : 11-MAR-13 / 25-MAR-18
Sponsor : Science Foundation Ireland (SFI)
Title : PIYRA - Gastric bypass and the regression of kidney disease in Type 2 diabetes: Identification of potential mechanisms.
Start Date / End Date : 01-JUL-13 / 01-JUL-18

Recent Postgraduates

PhD STUDENTS

Dr Alexander Miras (2010-2013): MRC Clinical Research Fellowship £398650

Dr Samantha Scholtz (2008-2013): Wellcome Clinical Research Fellowship £413540

Dr Marco Bueter (2008-2011): The Deutsche Forschungsgemeinschaft (German Research Foundation) £187345

Mr Hutan Ashrafian (2008-2013): Wellcome Clinical Research Fellowship £376490

Mr Dimitri Pournaras (2009-2012): Royal College of Surgeons¿ Fellowship £91200

Ms Ghalia Abdeen (2012-2016): Kingdom of Saudi Arabia Research Fellowship £75000

Ms Werd Al-Najim (2013-)

Dr Karl Neff (2012-2016)

Dr Jessie Elliott (2013-2016)

Mette Søndergaard Nielsen (2014-): Danish Diabetes Academy Fellow ¿191876

Meera Nair (2015-)

Dr Conor Murphy (2015-)

 

MPhil/MD STUDENTS

Dr Royce Vincent (2010-2012)

Dr Ling Ling Chuah (2012-2015)

Dr Aoife Canney (2014-2016)

 

MSc STUDENTS

Ms Sabrina Jackson (2013-2015)

Ms Alison Doody (2015-2016)

Ms Dora Gorman (2015-2016)

 

Teaching

Teaching Philosophy

Using state of the art technology to enhance the learning experience for students Prof le Roux was one of the first to introduce the ¿flipped class room¿ approach in the School of Medicine.
 

Enhancement of Teaching

I have pioneered the "Flipped Classroom" approach in Pathology teaching at UCD.

Review and Enhancement of Curriculum

As Head of Subject for Pathology between 2012 and 2015 I oversaw an in depth review of the entire Pathology curriculum.

Developing as a Teacher

I have attended several courses to improve my presentation style and thus have become a better communicator.
 

Collaborators

Internal Collaborators

Within the Diabetes Complications Research Centre at UCD which is led by Professor Catherine Godson, but also include Prof Helen Roche, Dr Neil Docherty, Dr Fiona McGuilicuddy, Dr Orina Belton, Prof Donal OShea and Dr John Crean. Other collaborators at University College Dublin Dr Patrick Twomey, Prof Steve Pennington.

Within the Section of Surgery and Surgical Specialities: Prof Ronan O'Connell and Prof Ronan Cahill

External Collaborators

                                                                      External collaborations include

Trinity College Dublin: John Reynolds

University of Gothenburg: Torsten Olbers, Lars Fandriks, Almantas Maleckas, Lena Carlsson, Per-Arne Svensson

Imperial College London: Steve Bloom, Alex Miras, Andrew Frankel, Fred Tam

University of Zurich: Thomas Lutz, Marco Bueter

King's College London: Francesco Rubino, Stephanie Amiel, Simon Aylwin, Ameet Patel, Cynthia Borg

Musgrove Hospital, Taunton: Richard Welbourn, Rob Andrews, Dimitri Pournaras, Alan Osborn

Florida State University: Alan Spector

Oswaldo Hospital, Soa Paulo: Ricardo Cohen

Catholic University of Chile: Camilo Boza

Saudi Arabia: Al-Qahtani, Ghalia Abdeen