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researcher

Catherine Godson

Professor

School Of Medicine
Conway Institute
Belfield
Dublin 4

Tel: +353 1 7166731
Email: catherine.godson@ucd.ie

Biography

I lead an international, multidisciplinary group of investigators including faculty, postdocs, clinical fellows, graduate students and undergraduates whose research focuses on innate immunity and chronic complications of diabetes. Our investigations have identified several novel modulators of disease and potential markers of susceptibility and progression of diabetic nephropathy. We collaborate closely with biopharma in an open innovation model. I have supervised 16 PhD students to completion and these are now engaged in industry, policy, clinical medicine and academic spheres.

I play a leadership role nationally and internationally including board membership of the Health Research Board, Ireland (2007-2012), the European Medical Research Council (2007-2012) and the Wellcome Trust Physiological Sciences Committee (2006-2009). I was elected to the Royal Irish Academy in 2011.

Professional

Honours and Awards

Year: 1984.
Title: Cystic Fibrosis Association Postgraduate Research Scholarship
Year: 1987.
Title: Young Investigator Award, Third International. Symposium on Nephrotoxicity
Year: 1989.
Title: University of California Cancer Research Coordinating Committee Post-Doctoral Fellowship
Year: 1990.
Title: American Heart Association Postdoctoral Fellowship
Year: 1992.
Title: University of Geneva Postdoctorante Award
Year: 1998.
Title: University College Dublin President¿s Research Award

Associations

Association: Wellcome Trust Physiological Sciences Review Panel , Function/Role: Member
Association: Health Research Board, Ireland , Function/Role: Member
Association: Editorial Board of Molecular Pharmacology , Function/Role: Member
Association: Irish Government¿s Chief Science Adviser¿s SWOT Analysis 2005, Function/Role: Member
Association: Wellcome Trust, National Kidney Research Fund (UK), National Institutes of Health, Function/Role: Grant reviewer
Association: NovaUCD, Function/Role: Board Member
Association: Dublin Molecular Medicine Centre , Function/Role: Board member

Patents

Patent PCT /IE 00/0026 : Identification of genes having a role in the presentation of diabetic nephropathy
   

Conference Contributions

Freeman JE., Godson C., and Kinsella, BT.; An investigation of thromboxane A2 and lipoxin A4 signalling in primary human mesangial cells. [Oral Presentation], Conway Institute of Biomolecular and Biomedical Research Festival of Research, University College Dublin, May 2002, * .
Brazil, DP., Kattla, JJ., Moran, RM., Roxburgh SR., Murphy M., Hemmings BA., Godson, C.; European Association for the Study of Diabetes (EASD). [Poster Presentation], European Association for the Study of Diabetes (EASD), Athens, Greece .
Kattla, JK, Roxburgh, SA, Godson C, Brazil, DP.; American Society of Nephrology. [Poster Presentation], American Society of Nephrology, Philadelphia, USA .
Freeman JE., Godson C., and Kinsella, BT.; An investigation of thromboxane A2 and lipoxin A4 signalling in primary human mesangial cells. Conway Institute of Biomolecular and Biomedical Research Festival of Research, University College Dublin, September 2001, .
Catherine GODSON; (2008) Lipoxin receptors and signal transduction. [Invited Lecture], European Conference on Lipid Mediators, Vallodolid, Spain , 12-JUN-08 - 14-JUN-08.
Catherine GODSON; (2008) FPRL Receptor Workshop. [Invited Lecture], fPRL-1 expression and bioactions in the resolution of inflammation, London June 2008, London June 2008 , 12-JUN-08 - 12-JUN-08.
Invited Speaker ; (2008) Diabetes and the kidney. Lipoxins, macrophages and diabetic nephropathy,. [Invited Lecture], International Society of Nephrology Nexus Symposium:, Dublin , 28-JUN-08 - 30-JUN-08.
Godson, C.; (2005) The thrill of biomedical discovery: new targets and markers in diabetic kidney disease. [Invited Oral Presentation], BA Festival of Science, Dublin , 01-JAN-05.
Godson, C.; (2005) Lipoxins and Annexin'1 regulate macrophage phagocytosis of apoptotic leukocytes. [Invited Oral Presentation], Gordon Research Conference, Phagocytic Clearance of Apoptotic Leukocytes, Connecticut , 01-JAN-05.
Godson, C.; (2005) Invited Speaker: Taking insult from injury: lipoxins pro-resolution, anti-fibrotic mediators in renal disease. [Invited Oral Presentation], International Conference on Eicosanoid Biology, San Francisco , 01-JAN-05.
Godson, C.; (2006) Invited Speaker: Monocyte-Endothelial Interactions. [Invited Oral Presentation], ISN Forefronts in Nephrology: Endothelial Biology and Renal Disease, Palisades New York , 01-MAR-06.
Godson, C.; (2006) Molecular mechanisms in the pathogenesis of diabetic nephropathy. [Keynote Address], European Renal Cell Study Group International Meeting, Dublin , 01-MAR-06.
Godson, C.; (2006) Phagocytosis of apoptotic cells in the resolution of inflammation. [Keynote Address], International Society of Histochemistry Annual Meeting, Stressa, Italy , 01-SEP-06.
Godson, C.; (2006) Resolvyx, Boston. [Invited Lecture], Resolvyx, Boston, Boston , 01-MAR-06.
Godson, C.; (2004) Berlex BioSciences. [Invited Lecture], Berlex BioSciences, Richmond, CA , 01-JAN-04.
Godson, C.; (2003) CellTech Ltd. [Invited Lecture], CellTech Ltd, Cambridge , 01-JAN-03.
Godson, C.; (2004) William Harvey Research Institute. [Invited Lecture], William Harvey Research Institute, Queen Mary College, London , 01-JAN-04.
Godson, C.; (2002) BioSciences Institute, University College Cork. [Invited Lecture], BioSciences Institute, University College Cork, UCC , 01-JAN-02.
Godson, C.; (2004) A Genomics Approach to Understanding the Pathogenesis of Diabetic Nephropathy. [Invited Oral Presentation], American Society of Nephrology Annual Meeting, St. Louis , 01-JAN-04.
Godson, C.; (2003) Regression of fibrosis, the physicians holy grail. [Chaired Session], American Society of Nephrology Annual Meeting, San Diego , 01-JAN-03.
Godson, C.; (2007) Panellist, Today's Research, Tomorrow's Prosperity: Commercializing University Research Symposium. [Other], Today's Research, Tomorrow's Prosperity: Commercializing University Research Symposium, University of Toronto , 01-MAY-07.

Committees

Committee : HRB Board Member
Committee : Wellcome Trust Physiological Sciences Review Committee
Committee : European Medical Research Council Board Member
Committee : Dublin Chamber Knowledge Economy Committee
Committee : Health Research Board Ireland, Molecular and Cell Biology Committee
Committee : Health Research Board Ireland, Cardiovascular, Renal and Respiratory Disease Committee
Committee : UCD Human Subjects Ethics Committee
 

Education

Year 1988 Institution: University College Dublin
Qualification: PhD Subject:
Year 1984 Institution: University College Dublin
Qualification: BSc Subject:
 

Consultancy

Client: Abbott Laboratories
Client: GE Life Sciences
Client: GSK, Greenford
Client: Boehringer-Ingelheim, Germany
Client: Resolvyx, Boston
   

Other Activities

Invited reviewer for J. Biol.Chem, Proc. Natl.Acad Sci USA, J. Immunol., Science, J. Am. Soc. Nephrol , Eur J. Biochem. Kid. Intl.
EXTERNAL EXAMINER:
University of Utrecht (2007), University of Warwick (2004), Trinity College Dublin (2005)

Publications

Books

Serhan, C.N. and Godson, C. (2011) Endogenous Anti-inflammatory and Proresolving Lipid Mediators in Renal Disease. : Elsevier Inc. [DOI] [Details]

Book Chapters

Serhan CN and Godson C (2011) 'ipid Mediators of Regeneration' In: Serhan CN and Godson C (eds). Regenerative Nephrology. NY: Elsevier/Academic Press. [Details]
Serhan, CN and Godson, C; (2010) 'pp 69-92' In: Serhan, CN and Godson, C; (eds). Lipid Mediators of Regeneration In: Regenerative Nephrology. Elsevier Academic Press: Elsevier Academic Press. [Details]
Ryan A, Sadlier, DM and Godson C Animal models of glomerulonphritis. In Fundamentals of Inflammation, Serhan, Ward and Gilroy (Eds.) Cambridge University Press, In press 2009; (2010) 'Animal models of glomerulonphritis' In: Ryan A, Sadlier, DM and Godson C Animal models of glomerulonphritis. In Fundamentals of Inflammation, Serhan, Ward and Gilroy (Eds.) Cambridge University Press, In press 2009; (eds). Fundamentals of Inflammation. NY: Cambridge University Press. [Details]
Maderna, P Godson,C ; (2007) 'Beyond inflammation: Lipoxins; resolution of inflammation and regulation of fibrosis' In: Rossi, Adriano; Sawatzky, Deborah A. (Eds.) (eds). The Resolution of Inflammation. Series: Progress in Inflammation Research. *: Birkhäuser. [Details]
 

Peer Reviewed Journals

Beaton H, Andrews D;Parsons M;Murphy M;Gaffney A;Kavanagh D;McKay GJ;Maxwell AP;Taylor CT;Cummins EP;Godson C;Higgins DF;Murphy P;Crean J (2016) 'Wnt6 regulates epithelial cell differentiation and is dysregulated in renal fibrosis'. American journal of physiology. Renal physiology, . [DOI] [Details]
Emma Börgesoncorrespondenceemail, Andrew M.F. Johnson, Yun Sok Lee, Andreas Till, Gulam Hussain Syed, Syed Tasadaque Ali-Shah,Patrick J. Guiry, Jesmond Dalli, Romain A. Colas, Charles N. Serhan, Kumar Sharma10, Catherine Godson (2015) 'Lipoxin A4 Attenuates Obesity-Induced Adipose Inflammation and Associated Liver and Kidney Disease'. Cell metabolism, . [DOI] [Details]
Crean D, Godson C (2015) 'Specialised lipid mediators and their targets'. Seminars in immunology, . [Details]
Todd JN, Dahlstr¿¿m EH;Salem RM;Sandholm N;Forsblom C; ;McKnight AJ;Maxwell AP;Brennan E;Sadlier D;Godson C;Groop PH;Hirschhorn JN;Florez JC (2015) 'Genetic Evidence for a Causal Role of Obesity in Diabetic Kidney Disease'. Journal of Diabetes, . [DOI] [Details]
Fionnuala B. Hickey*¿, James B. Corcoran*¿, Brenda Griffin*¿, Una Bhreathnach*¿, Heather Mortiboys#, Helen M. Reid¿, Darrell Andrews*¿, Shane Byrne*¿, Fiona Furlong§, Finian Martin*¿, Catherine Godson*¿+ and Madeline Murphy*¿+ (2014) 'IHG-1 INCREASES MITOCHONDRIAL FUSION AND BIOENERGETIC FUNCTION'. Diabetes, . [Details]
: Karen A Nolan, Ph.D; Eoin P Brennan, Ph.D; Carsten C Scholz, Ph.D; Cliodhna Cullen, B.Sc; Aidan Ryan, MB, Ph.D; Cormac T Taylor, Ph.D MRIA Catherine Godson PhD MRIA (2014) 'Paricalcitol protects against TGF-1 induced fibrotic responses in hypoxia and stabilises HIF- in renal epithelia'. Experimental Cell Research, . [Details]
Neff KJ, Frankel AH, Tam FW, Sadlier DM, Godson C, le Roux CW. (2013) 'The effect of bariatric surgery on renal function and disease: a focus on outcomes and inflammation'. Nephrology Dialysis Transplantation, . [DOI] [Details]
Brennan, EP,Nolan, KA,Borgeson, E,Gough, OS,McEvoy, CM,Docherty, NG,Higgins, DF,Murphy, M,Sadlier, DM,Ali-Shah, ST,Guiry, PJ,Savage, DA,Maxwell, AP,Martin, F,Godson, C (2013) 'Lipoxins Attenuate Renal Fibrosis by Inducing let-7c and Suppressing TGF beta R1'. Journal of the American Society of Nephrology : JASN, 24 :627-637. [DOI] [Details]
Murphy M, Hickey F, Godson C (2013) 'IHG-1 amplifies TGF-β1 signalling and mitochondrial biogenesis and is increased in diabetic kidney disease'. Current Opinion in Nephrology and Hypertension, 22 (1):77-84. [DOI] [Details]
Corcoran JB, McCarthy S, Griffin B, Gaffney A, Bhreathnach U, Börgeson E, Hickey FB, Docherty NG, Higgins DF, Furlong F, Martin F, Godson C, Murphy M (2013) 'IHG-1 must be localised to mitochondria to decrease Smad7 expression and amplify TGF-β1-induced fibrotic responses'. Biochimica et biophysica acta, 1833 (8):1969-1978. [DOI] [Details]
Sandholm N, McKnight AJ, Salem RM, Brennan EP, Forsblom C, Harjutsalo V, Mäkinen VP, McKay GJ, Sadlier DM, Williams WW, Martin F, Panduru NM, Tarnow L, Tuomilehto J, Tryggvason K, Zerbini G, Comeau ME, Langefeld CD; FIND Consortium, Godson C, Hirschhorn JN, Maxwell AP, Florez JC, Groop PH; FinnDiane Study Group and the GENIE Consortium (2013) 'Chromosome 2q31.1 associates with ESRD in women with type 1 diabetes'. Journal of the American Society of Nephrology, 24 (10):1537-1543. [Details]
Faherty, N., O'Donovan, H., Kavanagh, D., madden, S., McKay, GJ, Maxwell, AP., Martin, F., Godson, C and Crean, J. (2013) 'TGFβ and CCN2/CTGF mediate actin related gene 3 expression by differential E2F1/CREB activation'. BMC Genomics, . [Details]
Borgeson, E., McGillicuddy, F. C., Harford, K. A., Corrigan, N., Higgins, D. F., Maderna, P., Roche, H. M., Godson, C. (2012) 'Lipoxin A4 attenuates adipose inflammation'. FASEB Journal, 26 (10):4287-94. Available Online [Details]
O'Donovan, HC,Hickey, F,Brazil, DP,Kavanagh, DH,Oliver, N,Martin, F,Godson, C,Crean, J (2012) 'Connective tissue growth factor antagonizes transforming growth factor-beta 1/Smad signalling in renal mesangial cells'. Biochemical Journal, 441 :499-510. [DOI] [Details]
Curran, SP,Hickey, FB,Watson, A,Godson, C,Brazil, DP (2012) 'Deletion of Gremlin1 increases cell proliferation and migration responses in mouse embryonic fibroblasts'. Cellular Signalling, 24 :889-898. [DOI] [Details]
Brennan, EP,Morine, MJ,Walsh, DW,Roxburgh, SA,Lindenmeyer, MT,Brazil, DP,Gaora, PO,Roche, HM,Sadlier, DM,Cohen, CD,Godson, C,Martin, F (2012) 'Next-generation sequencing identifies TGF-beta 1-associated gene expression profiles in renal epithelial cells reiterated in human diabetic nephropathy'. Biochimica et Biophysica Acta - Molecular Basis of Disease, 1822 :589-599. [DOI] [Details]
Faherty N, Curran SP, O'Donovan H, Martin F, Godson C, Brazil DP, and Crean J (2012) 'CCN2/CTGF increases expression of miR-302 microRNAs, which target the TGFβ type II receptor with implications for nephropathic cell phenotypes'. Journal of Cell Science, . [Details]
¿ Sandholm N, Salem RM, McKnight AJ, Brennan EP, Forsblom C, Isakova T, McKay GJ, Williams WW, Sadlier DM, Mäkinen VP, Swan EJ, Palmer C, Boright AP, Ahlqvist E, Deshmukh HA, Keller BJ, Huang H, Ahola AJ, Fagerholm E, Gordin D, Harjutsalo V, He B, Heikkilä O, Hietala K, Kytö J, Lahermo P, Lehto M, Lithovius R, Osterholm AM, Parkkonen M, Pitkäniemi J, Rosengård-Bärlund M, Saraheimo M, Sarti C, Söderlund J, Soro-Paavonen A, Syreeni A, Thorn LM, Tikkanen H, Tolonen N, Tryggvason K, Tuomilehto J, Wadén J, Gill GV, Prior S, Guiducci C, Mirel DB, Taylor A, Hosseini SM; DCCT/EDIC Research Group, Parving HH, Rossing P, Tarnow L, Ladenvall C, Alhenc-Gelas F, Lefebvre P, Rigalleau V, Roussel R, Tregouet DA, Maestroni A, Maestroni S, Falhammar H, Gu T, Möllsten A, Cimponeriu D, Ioana M, Mota M, Mota E, Serafinceanu C, Stavarachi M, Hanson RL, Nelson RG, Kretzler M, Colhoun HM, Panduru NM, Gu HF, Brismar K, Zerbini G, Hadjadj S, Marre M, Groop L, Lajer M, Bull SB, Waggott D, Paterson AD, Savage DA, Bain SC, Martin F, Hirschhorn JN, Godson C, Florez JC, Groop PH, Maxwell AP. New susceptibility Loci associated with kidney disease in type 1 diabetes. PLoS Genet. 2012 Sep;8(9):e1002921. (2012) 'New susceptibility Loci associated with kidney disease in type 1 diabetes'. PLoS Genetics, . [Details]
Williams WW, Salem RM, McKnight AJ, Sandholm N, Forsblom C, Taylor A, Guiducci C, McAteer JB, McKay GJ, Isakova T, Brennan EP, Sadlier DM, Palmer C, Söderlund J, Fagerholm E, Harjutsalo V, Lithovius R, Gordin D, Hietala K, Kytö J, Parkkonen M, Rosengård-Bärlund M, Thorn L, Syreeni A, Tolonen N, Saraheimo M, Wadén J, Pitkäniemi J, Sarti C, Tuomilehto J, Tryggvason K, Osterholm AM, He B, Bain S, Martin F, Godson C, Hirschhorn JN, Maxwell AP, Groop PH, Florez JC (2012) 'Association Testing of Previously Reported Variants in a Large Case-Control Meta-Analysis of Diabetic Nephropathy'. Journal of Diabetes, . [DOI] [Details]
Wan, M,Godson, C,Guiry, PJ,Agerberth, B,Haeggstrom, JZ; (2011) 'Leukotriene B-4/antimicrobial peptide LL-37 proinflammatory circuits are mediated by BLT1 and FPR2/ALX and are counterregulated by lipoxin A(4) and resolvin E1'. FASEB Journal, 25 :1697-1705. [DOI] [Details]
Hickey, F Corcoran, J Docherty NG, Griffin, B Bhreathnach, U Furlong, F Martin, F Godson, C and Murphy, M ; (2011) 'IHG-1 regulates mitochondrial biogenesis through stabilisation of PGC-1α J Am Soc Nephrol 2011, in press'. . [Details]
Borgeson,E Dochery, NG Murphy,M Rodgers,K Ryan, A O¿Sullivan, T Guiry,P Goldschmeding, R Higgins DF and Godson, C. ; (2011) 'Lipoxin A4 and benzo-Lipoxin A4 attenuate experimental renal fibrosis. FASEB J'. . [Details]
Rooney, B,O'Donovan, H,Gaffney, A,Browne, M,Faherty, N,Curran, SP,Sadlier, D,Godson, C,Brazil, DP,Crean, J; (2011) 'CTGF/CCN2 activates canonical Wnt signalling in mesangial cells through LRP6: Implications for the pathogenesis of diabetic nephropathy'. FEBS Letters, 585 :531-538. [DOI] [Details]
Hickey, FB,Corcoran, JB,Docherty, NG,Griffin, B,Bhreathnach, U,Furlong, F,Martin, F,Godson, C,Murphy, M; (2011) 'IHG-1 Promotes Mitochondrial Biogenesis by Stabilizing PGC-1 alpha'. Journal of the American Society of Nephrology : JASN, 22 :1475-1485. [DOI] [Details]
Brennan, EP; Ehrich, M; O'Donovan, H; Brazil, DP; Crean, JK; Murphy, M; Sadlier, DM; Martin, F; Godson, C; McKnight, AJ; Van den Boom, D; Maxwell, AP; Savage, DA (2010) 'DNA methylation profiling in cell models of diabetic nephropathy'. Epigenetics : official journal of the DNA Methylation Society, 5 (5):396-401. Available Online [Details]
Duffy, CD,Maderna, P,McCarthy, C,Loscher, CE,Godson, C,Guiry, PJ; (2010) 'Synthesis and Biological Evaluation of Pyridine-Containing Lipoxin A(4) Analogues'. ChemMedChem, 5 :517-522. [DOI] [Details]
Nyhan KC, Faherty N, Murray G, Cooey LB, Godson C, Crean JK, Brazil DP.; (2010) 'Jagged/Notch signalling is required for a subset of TGFBeta1 responses in human kidney epithelial cells'. Biochima Et Biophysica Acta - Molecular Cell Research, 1803 :1386-1395. [Details]
Rooney B, O'Donovan, H., Browne, M., Gaffney, A., Curran, SP., Brazil, DP. Godson, C., Sadlier, D and Crean, JK. ; (2010) 'CTGF/CCN2 activates canonical Wnt signaling in mesangial cells through LRP6; implications for the pathogenesis of diabetic nephropathy'. European journal of biochemistry / FEBS, . [Details]
Ryan A, Godson C. ; (2010) 'Lipoxins: regulators of resolution'. CURRENT OPINION IN PHARMACOLOGY, 10 (2):166-172. [Details]
Connolly M, Marrelli A, Blades M, McCormick J, Maderna P, Godson C, Mullan R, FitzGerald O, Bresnihan B, Pitzalis C, Veale DJ, Fearon U; (2010) 'Acute serum amyloid A induces migration, angiogenesis, and inflammation in synovial cells in vitro and in a human rheumatoid arthritis/SCID mouse chimera model'. Journal of Immunology, 184 (11):6427-6437. [DOI] [Details]
Walsh DW, Godson C, Brazil DP, Martin F; (2010) 'Extracellular BMP-antagonist regulation in development and disease: tied up in knots'. Trends in Cell Biology, 20 (5):244-256. [DOI] [Details]
Nyhan, KC,Faherty, N,Murray, G,Cooey, LB,Godson, C,Crean, JK,Brazil, DP; (2010) 'Jagged/Notch signalling is required for a subset of TGF beta 1 responses in human kidney epithelial cells'. Cell, 1803 :1386-1395. [DOI] [Details]
Maderna, P,Cottell, DC,Toivonen, T,Dufton, N,Dalli, J,Perretti, M,Godson, C; (2010) 'FPR2/ALX receptor expression and internalization are critical for lipoxin A(4) and annexin-derived peptide-stimulated phagocytosis'. FASEB Journal, 24 :4240-4249. [DOI] [Details]
Borgeson, E,Godson, C; (2010) 'Molecular Circuits of Resolution in Renal Disease'. The Scientific World Journal, 10 :1370-1385. [DOI] [Details]
Brennan, EP; Ehrich, M; Brazil, DP; Crean, JK; Murphy, M; Sadlier, DM; Martin, F; Godson, C; McKnight, AJ; Van den Boom, D; Maxwell, AP; Savage, DA (2009) 'Comparative analysis of DNA methylation profiles in peripheral blood leukocytes versus lymphoblastoid cell lines'. Epigenetics : official journal of the DNA Methylation Society, 4 (3):159-164. Available Online [Details]
Roxburgh, S. A.,Kattla, J. J.,Curran, S. P.,O'Meara, Y. M.,Pollock, C. A.,Goldschmeding, R.,Godson, C.,Martin, F.,Brazil, D. P.; (2009) 'Allelic depletion of grem1 attenuates diabetic kidney disease'. Diabetes, 58 (77):1641-501641. Available Online [Details]
Godson C, Decker Y, McBean G, ; (2009) 'Lipoxin A4 inhibits IL-1beta-induced IL-8 and ICAM-1 expression in 1321N1 human astrocytoma cells'. American Journal of Physiology - Cell Physiology, 296 (6):1-7. [DOI] [Details]
Baker, N,O'Meara, SJ,Scannell, M,Maderna, P,Godson, C; (2009) 'Lipoxin A(4): Anti-Inflammatory and Anti-Angiogenic Impact on Endothelial Cells'. Journal of Immunology, 182 :3819-3826. [Details]
Brennan, EP,Ehrich, M,Brazil, DP,Crean, JK,Murphy, M,Sadlier, DM,Martin, F,Godson, C,McKnight, AJ,van den Boom, D,Maxwell, AP,Savage, DA; (2009) 'Comparative analysis of dna methylation profiles in peripheral blood leukocytes versus lymphoblastoid cell lines'. Gene, 4 :159-164. [Details]
Decker, Y,McBean, G,Godson, C; (2009) 'Lipoxin A(4) inhibits IL-1 beta-induced IL-8 and ICAM-1 expression in 1321N1 human astrocytoma cells'. Cell, 296 :1420-1427. [DOI] [Details]
Ryan, A.,Murphy, M.,Godson, C.,Hickey, F. B.; (2009) 'Diabetes mellitus and apoptosis: inflammatory cells'. Apoptosis, 14 (1212):1435-501435. Available Online [Details]
Maderna P and Godson C; (2009) 'Lipoxins: Resolutionary Road'. British Journal of Pharmacology, 158 (4):947-959. [Details]
Murphy, M,Docherty, NG,Griffin, B,Howlin, J,McArdle, E,McMahon, R,Schmid, H,Kretzler, M,Droguett, A,Mezzano, S,Brady, HR,Furlong, F,Godson, C,Martin, F; (2008) 'IHG-1 amplifies TGF-beta 1 signaling and is increased in renal fibrosis'. Journal of the American Society of Nephrology, 19 (NA):1672-1680. [DOI] [Details]
Decker, Y., Mc Bean, G., Godson, C., ; (2008) 'Anti-inflammatory effects of Lipoxin A4 in human 1321N1 astrocytoma cells'. Journal of Neuroimmunology, 197 (2):168-168. [Details]
O'Meara, S. J., Rodgers, K., Godson, C., ; (2008) 'Lipoxins: update and impact of endogenous pro-resolution lipid mediators'. Reviews of Physiology, Biochemistry and Pharmacology, Vol 160, 160 :47-69. [Details]
Godson C, Murphy M, Crean J, Brazil DP, Sadlier D, Martin F, ; (2008) 'Regulation and consequences of differential gene expression in diabetic kidney disease'. Biochemical Society Transactions, 36 (Pt 5):941-945. [DOI] [Details]
Murphy M, Crean JK, Brazil DP, Sadlier D, Martin F and Godson C ; (2008) 'Regulation and consequences of differential gene expression in diabetic kidney disease'. Biochem J, 36 :941-945. [Details]
Kane, R,Godson, C,O'Brien, C; (2008) 'Chordin-like 1, a bone morphogenetic protein-4 antagonist, is upregulated by hypoxia in human retinal pericytes and plays a role in regulating angiogenesis'. Molecular Vision, 14 :1138-1148. [Details]
Kattla, JJ,Carew, RM,Heljic, M,Godson, C,Brazil, DP; (2008) 'Protein kinase B/Akt activity is involved in renal TGF-beta 1-driven epithelial-mesenchymal transition in vitro and in vivo'. American Journal of Physiology - Renal Physiology, 295 :215-225. [DOI] [Details]
Mitchell D, O'Meara SJ, Gaffney A, Crean JK, Kinsella BT, Godson C.; (2007) 'The Lipoxin A4 Receptor Is Coupled to SHP-2 Activation:implications for regulation of receptor tyrosine kinases'. Journal of Biological Chemistry, 282 (21):15606-15618. [Details]
Guiry PJ, O'Sullivan TP, Vallin KS, Shah ST, Fakhry J, Maderna P, Scannell M, Sampaio AL, Perretti M, Godson C, ; (2007) 'Aromatic lipoxin A4 and lipoxin B4 analogues display potent biological activities'. Medicinal Chemistry, 24 (NA):5894-5902. [DOI] [Details]
Scannell, M,Flanagan, MB,Destefani, A,Wynne, KJ,Cagney, G,Godson, C,Maderna, P; (2007) 'Annexin-1 and peptide derivatives are released by apoptotic cells and stimulate phagocytosis of apoptotic neutrophils by macrophages'. Journal of Immunology, 178 :4595-4605. [Details]
Mitchell, DM., Gaffney, A., Crean, JK., Kinsella, BT. and Godson C; (2007) 'The lipoxin A4 receptor is coupled to SHP-2 activation; implications for regulating growth factor receptor signalling'. Journal of Biological Chemistry, . [Details]
Reville, K,Crean, JK,Vivers, S,Dransfield, I,Godson, C; (2006) 'Lipoxin A(4) redistributes myosin IIA and Cdc42 in macrophages: Implications for phagocytosis of apoptotic leukocytes'. Journal of Immunology, 176 :1878-1888. [Details]
Cummins, EP; Berra, E; Comerford, KM; Ginouves, A; Fitzgerald, KT; Seeballuck, F; Godson, C; Nielsen, JE; Moynagh, P; Pouyssegur, J; Taylor, CT; ; (2006) 'Prolyl hydroxylase-1 negatively regulates I kappa B kinase-beta, giving insight into hypoxia-induced NF kappa B activity'. Proceedings of the National Academy of Sciences of the United States of America, 103 (48):18154-18159. [Details]
Rodgers, K; Mitchell, D; O'Meara, S; Godson, C; ; (2006) 'Lipoxins: Potential anti-fibtrotic agents in models of inflammation'. Prostaglandins Other Lipid Mediators, 79 (1-2):168-168. [Details]
Crean, JK; Furlong, F; Mitchell, D; McArdle, E; Godson, C; Martin, F; ; (2006) 'Connective tissue growth factor/CCN2 stimulates actin disassembly through Akt/protein kinase B-mediated phosphorylation and cytoplasmic translocation of p27(Kip-1)'. FASEB Journal, 20 (10):1712. [Details]
Johnson RJ, Sadlier DM, Ouyang X, McMahon B, Mu W, Ohashi R, Rodgers K, Murray D, Nakagawa T, Godson C, Doran P, Brady HR, ; (2005) 'Microarray and bioinformatic detection of novel and established genes expressed in experimental anti-Thy1 nephritis'. Kidney International, 68 (6):2542-2561. [DOI] [Details]
Kane, R; Stevenson, L; Godson, C; Stitt, AW; O'Brien, C; ; (2005) 'Gremlin gene expression in bovine retinal pericytes exposed to elevated glucose'. British Journal of Ophthalmology, 89 (12):1638-1642. [Details]
Maderna, P; Godson, C; ; (2005) 'Taking insult from injury: Lipoxins and lipoxin receptor agonists and phagocytosis of apoptotic cells'. Prostaglandins Leukotrienes and Essential Fatty Acids, 73 (3-4):179-187. [Details]
Rodgers, K; McMahon, B; Mitchell, D; Sadlier, D; Godson, C; ; (2005) 'Lipoxin A(4) modifies platelet-derived growth factor-induced profibrotic gene expression in human renal mesangial cells'. American Journal of Pathology, 167 (3):683-694. [Details]
Crean, JK; Furlong, F; O'Leary, R; Mc Ardle, E; Godson, C; Martin, F; ; (2005) 'CTGF induces actin disassembly in mesangial cells through PI3 kinase mediated phosphorylation and cytoplasmic translocation of p27/kip-1 on serine 10 and subsequent downregulation of RhoA activity'. FASEB Journal, 19 (4):814-814. [Details]
Browne, JG, Kane, R, Godson, C, Cotter, TG, O'Brien, CJ, ; (2005) 'Glucose induction of apoptosis in human retinal pericytes'. Investigative Ophthalmology Visual Science, 46 (NA). [Details]
Maderna P, Yona S, Perretti M, Godson C. ; (2005) 'Modulation of phagocytosis of apoptotic neutrophils by supernatant from dexamethasone-treated macrophages and annexin-derived peptide Ac(2-26)'. Journal of Immunology, 174 (6):3727-3733. [Details]
Leonard MO, Godson C, Brady HR, Taylor CT; (2005) 'Potentiation of glucocorticoid activity in hypoxia through induction of the glucocorticoid receptor'. Journal of Immunology, 174 (4):2250-2257. [Details]
Brady HR, Dolan V, Murphy M, Sadlier D, Lappin D, Doran P, Godson C, Martin F, O'Meara Y, Schmid H, Henger A, Kretzler M, Droguett A, Mezzano S, ; (2005) 'Expression of gremlin, a bone morphogenetic protein antagonist, in human diabetic nephropathy'. American Journal of Kidney Diseases, 45 (6):1034-1039. [Details]
Ohse, T,Ota, T,Kieran, N,Godson, C,Yamada, K,Tanaka, T,Fujita, T,Nangaku, M; (2004) 'Modulation of interferon-induced genes by lipoxin analogue in anti-glomerular basement membrane nephritis'. Journal of the American Society of Nephrology : JASN, 15 :919-927. [DOI] [Details]
Mitchell, D; Rodgers, K; Hanly, J; McMahon, B; Brady, HR; Martin, F; Godson, C; ; (2004) 'Lipoxins inhibit Akt/PKB activation and cell cycle progression in human mesangial cells'. American Journal of Pathology, 164 (3):937-946. [Details]
Browne, JG; Kane, R; Godson, C; Cotter, TG; O'Brien, CJ; ; (2004) 'Mechanism of pericyte apoptosis following glucose exposure'. Investigative Ophthalmology Visual Science, 45 (NA):88-88. [Details]
Crean, JK; Furlong, F; Finlay, D; Mitchell, D; Conway, B; Brady, HR; Godson, C; Martin, F; ; (2004) 'Connective tissue growth factor [CTGF]/CCN2 stimulates mesangial cell migration through integrated dissolution of focal adhesion complexes and activation of cell polarization'. FASEB Journal, 18 (11):1541. [Details]
McMahon, B; Godson, C; ; (2004) 'Lipoxins: endogenous regulators of inflammation'. American Journal of Physiology - Renal Physiology, 286 (2):189-201. [Details]
Kieran NE Maderna P and Godson C. ; (2004) 'Lipoxins: potential anti-inflammatory, proresolution, and antifibrotic mediators in renal disease'. Kidney International, 65 (4):1145-1154. [Details]
Gallagher J, Howlin J, Mc Carthy C, Murphy E, Bresnihan B, FitzGerald O, Godson C, Brady HR and Finian Martin.; (2003) 'Identification of Naf1/ABIN-1 among TNF-alpha-induced expressed genes in human synoviocytes using oligonucleotide microarrays'. FEBS Letters, 551 :8-12. [Details]
McMahon, B; Rodgers, K; Mitchell, D; Brady, HR; Godson, C; ; (2003) 'Lipoxin A(4) modulation of platelet-derived growth factor-induced transcriptional responses in human renal mesangial cells'. Journal of the American Society of Nephrology : JASN, 14 (NA):62-62. [Details]
Reville, K; Brady, HR; Godson, C; ; (2003) 'Functional proteomics of lipoxin-stimulated macrophage function'. Journal of the American Society of Nephrology : JASN, 14 (NA):87-87. [Details]
Murphy, M; Curtin, D; Dolan, V; Hensey, C; Kretzler, M; Schlondorff, D; Godson, C; Brady, HR; Martin, F; ; (2003) 'IHG-1 enhances TGF-beta-induced transcriptional activation and its expression is increased in diabetic nephropathy'. Journal of the American Society of Nephrology : JASN, 14 (NA):127-128. [Details]
Mitchell, DM; Rodgers, K; Petasis, NA; Brady, HR; Godson, C; ; (2003) 'Lipoxins modulate Akt/PKB activation and cell cycle progression in mesangial cells'. Journal of the American Society of Nephrology : JASN, 14 (NA):340-340. [Details]
Ohse, T; Ota, T; Kieran, N; Godson, C; Yamada, K; Tanaka, T; Fujita, T; Nangaku, M; ; (2003) 'Modulation of interferon-induced genes by lipoxin analogue in Anti-GBM nephritis'. Journal of the American Society of Nephrology : JASN, 14 (NA):635-635. [Details]
Kane, R; Godson, C; Brady, HR; O'Brien, C; ; (2003) 'Differential gene expression in human retinal pericytes in response to glucose and hypoxia'. Investigative Ophthalmology Visual Science, 44 (NA):395-395. [Details]
Maderna, P; Godson, C; ; (2003) 'Phagocytosis of apoptotic cells and the resolution of inflammation'. Biochimica et Biophysica Acta - Molecular Basis of Disease, 1639 (3):141-151. [Details]
Leonard, MO; Godson, C; Brady, HR; Taylor, CT; ; (2003) 'Involvement of HIF-1 alpha in hypoxia mediated alterations in human proximal tubular epithelial cell transcription'. Journal of the American Society of Nephrology : JASN, 14 (NA):24-24. [Details]
Leonard, MO; Cottell, DC; Godson, C; Brady, HR; Taylor, CT; ; (2003) 'The role of HIF-1 alpha in transcriptional regulation of the proximal tubular epithelial cell response to hypoxia'. Journal of Biological Chemistry, 278 (41):40296-40304. [Details]
Duffy, TN; Fearon, U; Godson, C; Brady, H; Bresnihan, B; Veale, D; FitzGerald, O; ; (2003) 'Profibrotic mRNA is preferentially expressed in bone forming arthritis'. Arthritis and Rheumatism, 48 (9):602-602. [Details]
Higgins, DF,Lappin, DWP,Kieran, NE,Anders, HJ,Watson, RWG,Strutz, F,Schlondorff, D,Haase, VH,Fitzpatrick, JM,Godson, C,Brady, HR; (2003) 'DNA oligonucleotide microarray technology identifies fisp-12 among other potential fibrogenic genes following murine unilateral ureteral obstruction (UUO): Modulation during epithelial-mesenchymal transition'. Kidney International, 64 :2079-2091. [Details]
Kieran, NE,Doran, PP,Connolly, SB,Greenan, MC,Higgins, DF,Leonard, M,Godson, C,Taylor, CT,Henger, A,Kretzler, M,Burne, MJ,Rabb, H,Brady, HR; (2003) 'Modification of the transcriptomic response to renal ischemia/reperfusion injury by lipoxin analog'. Kidney International, 64 :480-492. [Details]
Goh, J.,Godson, C.,Brady, H. R.,Macmathuna, P.; (2003) 'Lipoxins: pro-resolution lipid mediators in intestinal inflammation'. Gastroenterology, 124 (4):1043-54. [Details]
Clarkson, M., Murphy, M., Gupta, S., Mackenzie, H.S., Godson, C., Martin F., Brady, H.R. ; (2002) 'High glucose-altered gene expression in mesangial cells. Actin-regulatory protein gene expression is triggered by oxidative stress and cytoskeletal disassembly'. Journal of Biological Chemistry, 277 (12):9707-9712. [Details]
Mitchell, DM; Hanly, J; Petasis, NA; Brady, HR; Godson, C; ; (2002) 'The lipoxin A(4) receptor is coupled to antiproliferative responses'. Journal of the American Society of Nephrology : JASN, 13 (NA):85-85. [Details]
Leonard, MO; Cottell, D; Godson, C; Brady, HR; Taylor, CT; ; (2002) 'Gene expression profile clustering of proximal tubule epithelial cells in hypoxia and reoxygenation'. Journal of the American Society of Nephrology : JASN, 13 (NA):118-118. [Details]
Mitchell, S; Thomas, G; Harvey, K; Cottell, D; Reville, K; Berlasconi, G; Petasis, NA; Erwig, L; Rees, AJ; Savill, J; Brady, HR; Godson, C; ; (2002) 'Lipoxins, aspirin-triggered epi-lipoxins, lipoxin stable analogues, and the resolution of inflammation: Stimulation of macrophage phagocytosis of apoptotic neutrophils in vivo'. Journal of the American Society of Nephrology : JASN, 13 (10):2497-2507. [Details]
Lappin, DWP; Doran, P; Godson, C; Brady, HR; ; (2002) 'Gene responses to hyperglycaemia'. Experimental Nephrology, 10 (2):120-129. [Details]
Stenson, C; Mitchell, S; Lappin, D; Brady, HR; Godson, C; ; (2002) 'Biphasic regulation of leukocyte trafficking by lipoxins'. Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury, 5, 507 (NA):543-549. [Details]
Maderna, P, Cottell, DC, Berlasconi, G, Petasis, NA, Brady, HR, Godson, C, ; (2002) 'Lipoxins induce actin reorganization in monocytes and macrophages but not in neutrophils - Differential involvement of Rho GTPases'. American Journal of Pathology, 160 (6):2275-2283. [Details]
McMahon, B,Mitchell, D,Shattock, R,Martin, F,Brady, HR,Godson, C; (2002) 'Lipoxin, leukotriene, and PDGF receptors cross-talk to regulate mesangial cell proliferation'. FASEB Journal, 16 :1817. [DOI] [Details]
Leonard, MO; Hannan, K; Burne, MJ; Lappin, DWP; Doran, P; Coleman, P; Stenson, C; Taylor, CT; Daniels, F; Godson, C; Petasis, NA; Rabb, H; Brady, HR; ; (2002) '15-Epi-16-(para-fluorophenoxy)-lipoxin A(4)-methyl ester, a synthetic analogue of 15-epi-lipoxin A(4), is protective in experimental ischemic acute renal failure'. Journal of the American Society of Nephrology : JASN, 13 (6). [Details]
Crean, JKG; Finlay, D; Murphy, M; Moss, C; Godson, C; Martin, F; Brady, HR; ; (2002) 'The role of p42/44 MAPK and protein kinase B in connective tissue growth factor induced extracellular matrix protein production, cell migration, and actin cytoskeletal rearrangement in human mesangial cells'. Journal of Biological Chemistry, 277 (46):44187-44194. [Details]
Lappin, DWP; Mullally, A; Kairaitis, L; Wang, YP; Godson, C; Harris, DCH; Brady, HR; Doran, PP; ; (2002) 'Temporal patterns of gene expression in adriamycin-induced nephrosis'. Journal of the American Society of Nephrology : JASN, 13 (NA):117-117. [Details]
Kieran, NE; Connolly, SB; Greenan, MC; Higgins, D; Burne, MJ; Godson, C; Doran, PP; Rabb, H; Brady, HR; ; (2002) 'The transcriptomic response to renal ischemia-reperfusion injury and its modification by lipoxin A4 analogue FphO-15-RLXA4-Me'. Journal of the American Society of Nephrology : JASN, 13 (NA):120-120. [Details]
Higgins, DF; Lappin, DWP; Isaka, Y; Watson, RW; Godson, C; Imai, E; Fitzpatrick, JM; Brady, HR; ; (2002) 'Transcriptomic responses underpinning renal tubulointerstitial fibrosis as identified by DNA oligonucleotide microarray technology'. Journal of the American Society of Nephrology : JASN, 13 (NA):560-560. [Details]
Stenson, C.,Mitchell, S.,Lappin, D.,Brady, H. R.,Godson, C.; (2002) 'Biphasic regulation of leukocyte trafficking by lipoxins'. Adv Exp Med Biol, 507 :543-9. [Details]
McMahon, R; Murphy, M; Gardiner, C; Godson, C; Martin, F; Brady, HR; ; (2001) 'Gremlin inhibits DNA synthesis and proliferation in human mesangial cells by a BMP independent mechanism'. British Journal of Pharmacology, 134 (NA). [Details]
Maderna, P; Brady, HR; Godson, C; ; (2001) 'Lipoxins induce reorganisation of the actin cytoskeleton in monocyte-derived macrophages: The role of RhoA'. British Journal of Pharmacology, 134 (NA). [Details]
McMahon, B; Mitchell, S; Brady, HR; Godson, C; ; (2001) 'Lipoxins: revelations on resolution'. Trends in Pharmacological Sciences, 22 (8):391-395. [Details]
Goh, J; Baird, AW; O'Keane, C; Watson, RWG; Cottell, D; Bernasconi, G; Petasis, NA; Godson, C; Brady, HR; MacMathuna, P; ; (2001) 'Lipoxin A(4) and aspirin-triggered 15-epi-lipoxin A(4) antagonize TNF-alpha-stimulated neutrophil-enterocyte interactions in vitro and attenuate TNF-alpha-induced chemokine release and colonocyte apoptosis in human intestinal mucosa ex vivo'. Journal of Immunology, 167 (5):2772-2780. [Details]
Crean, J. K.,Lappin, D.,Godson, C.,Brady, H. R.; (2001) 'Connective tissue growth factor: an attractive therapeutic target in fibrotic renal disease'. Expert Opin Ther Targets, 5 (4):519-530. [Details]
Crean JK, Lappin D, Godson C, Brady HR; (2001) 'Connective tissue growth factor: an attractive therapeutic target in fibrotic renal disease'. Expert Opinion on Therapeutic Targets, 5 (4):519-530. [Details]
Freeman JE, Godson C & Kinsella BT.; (2001) 'An investigation into thromboxane A2 and lipoxin A4 signalling in primary human mesangial cells'. British Journal of Pharmacology, 134 :83p. [Details]
Godson, C,Mitchell, S,Harvey, K,Petasis, NA,Hogg, N,Brady, HR; (2000) 'Cutting edge: Lipoxins rapidly stimulate nonphlogistic phagocytosis of apoptotic neutrophils by monocyte-derived macrophages'. Journal of Immunology, 164 :1663-1667. [Details]
McMahon, B; Stenson, C; McPhillips, F; Fanning, A; Brady, HR; Godson, C; ; (2000) 'Lipoxin A(4) antagonizes the mitogenic effects of leukotriene D-4 in human renal mesangial cells - Differential activation of MAP kinases through distinct receptors'. Journal of Biological Chemistry, 275 (36):27566-27575. [Details]
McMahon, R; Murphy, M; Clarkson, M; Taal, M; Mackenzie, HS; Godson, C; Martin, F; Brady, HR; ; (2000) 'IHG-2, a mesangial cell gene induced by high glucose, is human gremlin - Regulation by extracellular glucose concentration, cyclic mechanical strain, and transforming growth factor-beta 1'. Journal of Biological Chemistry, 275 (14):9901-9904. [Details]
Diamond, P; McGinty, A; Jiao, QS; Murphy, B; Godson, C; Sugrue, D; McCann, H; Brady, HR; ; (2000) 'Expression of suppressors of cytokine signalling (SOCS) in experimental cardiac transplant rejection'. Journal of the American College of Cardiology, 35 (2):221-221. [Details]
McMahon, B; Stenson, C; Brady, HR; Godson, C; ; (2000) 'Lipoxin A4 modulates Leukotriene D4-induced mitogenesis in renal mesangial cells'. FASEB Journal, 14 (8):1346-1346. [Details]
Lappin, DWP; Hensey, C; McMahon, R; Godson, C; Brady, HR; ; (2000) 'Gremlins, glomeruli and diabetic nephropathy'. Current Opinion in Nephrology and Hypertension, 9 (5):469-472. [Details]
Godson, C.,Brady, H. R.; (2000) 'Lipoxins: novel anti-inflammatory therapeutics?'. Curr Opin Investig Drugs, 1 (3):380-5. [Details]
Maderna, P; Godson, C; Hannify, G; Murphy, M; Brady, HR; ; (2000) 'Influence of lipoxin A(4) and other lipoxygenase-derived eicosanoids on tissue factor expression'. American Journal of Physiology - Cell Physiology, 279 (4):945-953. [Details]
Goh, J; Baird, AW; Watson, WR; Godson, C; O'Keane, C; Brady, HR; MacMathuna, P; ; (2000) 'Lipoxins attenuate TNF-A-induced apoptosis in human colonic mucosa'. Journal of Gastroenterology, 118 (4):806-806. [Details]
Murphy, M; Godson, C; Martin, F; Brady, HR; ; (1999) 'Gene expression in cultured human mesangial cells in response to extracellular glucose as assessed by suppressive subtractive hybridization'. Kidney International, 55 (6):2585-2585. [Details]
Diamond, P; McGinty, A; Sugrue, D; Brady, HR; Godson, C; ; (1999) 'Regulation of leukocyte trafficking by lipoxins'. Clinical Chemistry and Laboratory Medicine, 37 (3):293-297. [Details]
Clarkson, M; Cannon, S; Godson, C; Jones, D; Horan, J; Mulkerrin, E; Brady, HR; ; (1999) 'Pathophysiology of hyperkalaemia in elderly patients'. Kidney International, 55 (6):2582-2582. [Details]
Maderna, P; Chanyaputhipong, P; Petasis, NA; Godson, C; Brady, HR; ; (1999) 'Protein kinase C-dependent stereospecific regulation of endothelial cell tissue factor gene expression by lipoxins'. Kidney International, 55 (6):2578-2579. [Details]
McMahon, B; McPhillips, F; Fanning, A; Brady, HR; Godson, C; ; (1999) 'Modulation of mesangial cell MAP kinase activities by leukotrien D-4 and lipoxin A(4)'. Kidney International, 55 (6):2578-2578. [Details]
Maderna, P; Coleman, P; Godson, C; O'Meara, YM; Brady, HR; ; (1999) 'Haemodialysis serum inhibits endothelial cell (EC) expression of tissue factor (TF)'. Kidney International, 55 (6):2575-2575. [Details]
Mitchell, S; Harvey, K; Fokin, VV; Petasis, NA; Godson, C; Brady, HR; ; (1999) 'Lipoxins stimulate macrophages to phagocytose apoptotic neutrophils'. Kidney International, 55 (6):2574-2574. [Details]
Clarkson, MR; Gupta, S; Murphy, M; Martin, F; Godson, C; Brady, HR; ; (1999) 'Connective tissue growth factor: a potential stimulus for glomerulosclerosis and tubulointerstitial fibrosis in progressive renal disease'. Current Opinion in Nephrology and Hypertension, 8 (5):543-548. [Details]
Mitchell, S; Harvey, K; Fokin, VV; Petasis, NA; Godson, C; Brady, HR; ; (1999) 'Lipoxins stimulate macrophage phagocytosis of apoptotic neutrophils'. FASEB Journal, 13 (4):557-557. [Details]
Murphy, M; Godson, C; Cannon, S; Martin, F; Brady, HR; ; (1999) 'Connective tissue growth factor expression in human mesangial cells exposed to high glucose'. FASEB Journal, 13 (4):37-37. [Details]
Maderna, P; Coleman, P; Godson, C; O'Meara, YM; Brady, HR; ; (1999) 'Serum from hemodialysis patients inhibits basal and cytokine-stimulated tissue factor expression in vitro'. Journal of the American Society of Nephrology : JASN, 10 (11):2403-2406. [Details]
Murphy, M., Godson, C., Cannon, S., Kato, S., Mackenzie, H.S., Martin, F., Brady, H.R. ; (1999) 'Suppression subtraction hybridization identifies high glucose levels as a stimulus for expression of connective tissue growth factor and other genes in human mesangial cells'. Journal of Biological Chemistry, 274 :5830-5834. [Details]
Maher, LJ; Skelly, MM; Godson, C; Brady, HR; Baird, AW; ; (1999) 'Lipoxin A(4) inhibits mast cell stimulation in rat colon in vitro'. Journal of Gastroenterology, 116 (4):905-905. [Details]
Bosio, PM; Cannon, S; Godson, C; McKenna, PJ; O'Herlihy, C; Conroy, R; McCann, H; Sugrue, D; Brady, HR; ; (1999) 'Hyperdynamic circulation and elevated plasma levels of soluble p-selectin precede the development of peripheral vasoconstriction and hypertension in women destined to develop pre-eclampsia'. Kidney International, 55 (6):2581-2581. [Details]
Murphy, M; Godson, C; Cannon, S; Martin, F; Brady, HR; ; (1999) 'Connective tissue growth factor expression in human mesangial cells exposed to high glucose'. Kidney International, 55 (6):2585-2585. [Details]
Clarkson, MR; McGinty, A; Godson, C; Brady, HR; ; (1998) 'Leukotrienes and lipoxins: lipoxygenase-derived modulators of leukocyte recruitment and vascular tone in glomerulonephritis'. Nephrology Dialysis Transplantation, 13 (12):3043-3051. [Details]
Murphy, M; McGinty, A; Godson, C; ; (1998) 'Protein kinases C: potential targets for intervention in diabetic nephropathy'. Current Opinion in Nephrology and Hypertension, 7 (5):563-570. [Details]
GODSON, C,RYAN, MP,BRADY, HR,BOURKE, S,FITZGERALD, MX; (1988) 'ACUTE HYPOMAGNESEMIA COMPLICATING THE TREATMENT OF MECONIUM ILEUS EQUIVALENT IN CYSTIC-FIBROSIS'. Journal of Gastroenterology, 23 :148-150. [Details]
Godson, C.,Ryan, M. P.,O'Halloran, D.,Bourke, S.,Brady, H. R.,FitzGerald, M. X.; (1988) 'Investigation of aminoglycoside nephrotoxicity in cystic fibrosis patients'. Scand J Gastroenterol Suppl, 143 :70-3. [Details]
Godson, C.,Ryan, M. P.,Brady, H. R.,Bourke, S.,FitzGerald, M. X.; (1988) 'Acute hypomagnesaemia complicating the treatment of meconium ileus equivalent in cystic fibrosis'. Scand J Gastroenterol Suppl, 143 :148-50. [Details]
GODSON, C,RYAN, MP,OHALLORAN, D,BOURKE, S,BRADY, HR,FITZGERALD, MX; (1988) 'INVESTIGATION OF AMINOGLYCOSIDE NEPHROTOXICITY IN CYSTIC-FIBROSIS PATIENTS'. Journal of Gastroenterology, 23 :70-73. [Details]
GODSON, C, RYAN, MP, BRAYDEN, D, BRADY, HB, FITZGERALD, MX, ; (1986) 'INVESTIGATION OF MAGNESIUM STATUS IN PATIENTS WITH CYSTIC-FIBROSIS'. Irish Journal of Medical Science, 155 (4):133-134. [Details]
GODSON, C, BRAYDEN, D, BRADY, HR, WALLEY, T, FITZGERALD, MX, RYAN, MP, ; (1985) 'PREVALENCE AND CAUSES OF MAGNESIUM-DEFICIENCY IN AMBULATORY AND HOSPITALIZED-PATIENTS WITH CYSTIC-FIBROSIS'. Journal of the American College of Nutrition, 4 (3):370-370. [Details]
 

Conference Publications

Kavanagh, D., Gaffney A., Murphy, M., Faherty, N., Andrews, D., Higgins, D., McKay, G., Maxwell, P., Godson, C. and Crean, J. (2012) Wnt 6 is increased in diabetic nephropathy and modulates de novo tubulogenesis and opposes TGFbeta mediated epithelial cell differentiation in vitro American Society of Nephrology [Details]
Faherty N, Curran SP, O'Donovan H, Martin F, Godson C, Brazil DP, and Crean J. (2011) CCN2/CTGF increases expression of miR-302 microRNAs, which target the TGFβ type II receptor with implications for nephropathic cell phenotypes American Society of Nephrology [Details]
O'Donovan, H. 1, Xu, L.3, Oliver, N.3, Godson, C.2, and Crean, JK; (2010) CTGF/CCN2 and TGFBeta Superfamily signalling: Implications for therapeutic intervention American Society of Nephrology [Details]
Browne, M., Faherty, N.1, Xu, L., Oliver, N., Brazil, D. , Godson, C. and Crean, J. ; (2010) Connective Tissue Growth Factor (CTGF) causes Cdc42 activation and altered actin binding protein expression in the glomerular podocyte American Society of Nephrology [Details]
Rooney B, Gaffney, A., Godson, C., Sadlier, D and Crean, JK.; (2010) CTGF/CCN2 activates canonical Wnt signaling in mesangial cells through LRP6; implications for the pathogenesis of diabetic nephropathy American Society of Nephrology [Details]
Godson C, Murphy M, Crean J, Brazil DP, Sadlier D, Martin F, ; (2008) Biochemical Society transactions Regulation and consequences of differential gene expression in diabetic kidney disease , pp.941-945 [DOI] [Details]
Shah, S.T. A., O'Sullivan, T.P., Maderna, P., Godson, C. and Guiry, P.J.; (2005) The total synthesis of novel lipoxin A4 analogues for biological evaluation Recent Advances in Synthesis and Chemical Biology IV [Details]
Shah, S.T. A., O'Sullivan, T.P., Maderna, P., Godson, C. Guiry, P.J.; (2005) The total synthesis of novel lipoxin A4 analogues for biological evaluation Recent Advances in Synthesis and Chemical Biology IV [Details]
Shah, S.T. A., O'Sullivan, T.P., Maderna, P., Godson, C. Guiry, P.J.; (2005) The total synthesis of novel lipoxin A4 analogues for biological evaluation UCD Conway Festival of Research [Details]
Shah, S. T. A.; O'Sullivan, T. P.; Maderna, P.; Godson, C.; Guiry, P. J.; (2005) The total synthesis of novel lipoxin A4 analogues for biological evaluation UCD Conway Festival of Research [Details]
Shah, S.T. A., O'Sullivan, T.P., Maderna, P., Godson, C. Guiry, P.J.; (2005) The total synthesis of novel lipoxin A4 analogues for biological evaluation UCD Conway Festival of Research [Details]
Shah, S.T. A., O'Sullivan, T.P., Maderna, P., Godson, C. Guiry, P.J.; (2005) The total synthesis of novel lipoxin A4 analogues for biological evaluation UCD Conway Festival of Research [Details]
Shah, S.T. A., O'Sullivan, T.P., Maderna, P., Godson, C. Guiry, P.J.; (2005) The total synthesis of novel lipoxin A4 analogues for biological evaluation Recent Advances in Synthesis and Chemical Biology IV [Details]
Murphy, M; Curtin, D; Dolan, V; Hensey, C; Kretzler, M; Schlondorff, D; Godson, C; Brady, HR; Martin, F; ; (2003) JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY IHG-1 enhances TGF-beta-induced transcriptional activation and its expression is increased in diabetic nephropathy , pp.127-128 [Details]
Freeman JE., Godson C., and Kinsella, BT.; (2001) An investigation of thromboxane A2 and lipoxin A4 signalling in primary human mesangial cells Conway Institute of Biomolecular and Biomedical Research Festival of Research University College Dublin, [Details]
Freeman JE., Godson C., and Kinsella, BT.; (2001) An investigation of thromboxane A2 and lipoxin A4 signalling in primary human mesangial cells British Pharmacological Society Dublin, [Details]
Freeman JE., McMahon, B., Godson C., and Kinsella, BT.; (2001) Characterisation of thromboxane A2 and lipoxin A4 signalling in human mesangial cells Irish Nephrological Society AGM Royal College of Physicians of Ireland, [Details]
                       

Abstract

Decker Y., McBean G. and Godson C.; (2008) Anti-inflammatory effects of lipoxin A4 in human 1321N1 astrocytoma cells. J. Neuroimmunol. 197, p168: Abstract [Details]
       

Reviews

Murphy, M,Hickey, F,Godson, C (2013) IHG-1 amplifies TGF-beta 1 signalling and mitochondrial biogenesis and is increased in diabetic kidney disease. Reviews [DOI] [Details]
Ryan, AD,Godson, C (2010) Lipoxins: regulators of resolution. Reviews [DOI] [Details]
Walsh, DW,Godson, C,Brazil, DP,Martin, F (2010) Extracellular BMP-antagonist regulation in development and disease: tied up in knots. Reviews [DOI] [Details]
Maderna, P,Godson, C (2009) Lipoxins: resolutionary road. Reviews [DOI] [Details]
Ryan, A,Murphy, M,Godson, C,Hickey, FB (2009) Diabetes mellitus and apoptosis: inflammatory cells. Reviews [DOI] [Details]
O'Meara, SJ,Rodgers, K,Godson, C (2008) Lipoxins: update and impact of endogenous pro-resolution lipid mediators. Reviews [DOI] [Details]
Maderna, P,Godson, C (2005) Taking insult from injury: Lipoxins and lipoxin receptor agonists and phagocytosis of apoptotic cells. Reviews [DOI] [Details]
McMahon, B,Godson, C (2004) Lipoxins: endogenous regulators of inflammation. Reviews [DOI] [Details]
Goh, J,Godson, C,Brady, HR,MacMathuna, P (2003) Lipoxins: Pro-resolution lipid mediators in intestinal inflammation. Reviews [DOI] [Details]
Maderna, P,Godson, C (2003) Phagocytosis of apoptotic cells and the resolution of inflammation. Reviews [DOI] [Details]
Lappin, DWP,Doran, P,Godson, C,Brady, HR (2002) Gene responses to hyperglycaemia. Reviews [Details]
Lappin, DWP,Hensey, C,McMahon, R,Godson, C,Brady, HR (2000) Gremlins, glomeruli and diabetic nephropathy. Reviews [Details]
Clarkson, MR,Gupta, S,Murphy, M,Martin, F,Godson, C,Brady, HR (1999) Connective tissue growth factor: a potential stimulus for glomerulosclerosis and tubulointerstitial fibrosis in progressive renal disease. Reviews [Details]
Murphy, M,McGinty, A,Godson, C (1998) Protein kinases C: potential targets for intervention in diabetic nephropathy. Reviews [Details]
   

Presentation

Crean JK, Finlay D, Godson C, Martin F, Brady HR; (2002) Connective Tissue Growth Factor induces adhesion, contraction and cytoskeletal rearrangement in human mesangial cells: the role of Erk and Rho Kinases. Presentation [Details]
Crean JK, Finlay D, Martin F, Godson C, Brady HR; (2002) The role of p42/44 MAPK and protein kinase B in connective tissue growth factor induced extracellular matrix protein production, cell migration and actin cytoskeletal rearrangement in human mesangial cells. Presentation [Details]
                                               

Research

Research Interests

Microvascular complications of diabetes and TGF signalling networks
Mammalian cell signal transduction
The resolution of inflammatory responses

Work in our laboratory focuses on understanding signal transduction processes implicated in disease states such as inflammation and diabetes. We are particularly interested in understanding the mechanisms underlying the resolution of inflammation. It is increasingly appreciated that the resolution of inflammation is a dynamically regulated process. Whereas inflammation is appropriate to effective host defence, in several chronic disease including the arthritides, atherosclerosis and colitis, chronic inflammation persists contributing to the pathology of these conditions. The resolution of inflammation does not merely reflect the dissipation of proinflammatory signals but the active generation of anti-inflammatory mediators, which included the lipoxins.

RESEARCH FUNDING:
Principal Investigator on the following Grants (1998-2007)
2007-2013 Science Foundation Ireland Investigator Award, Molecular Mechanisms of the Initiation, Progression and Potential Regression of Diabetic Kidney Disease. Total value €7.5 m; €3.5 m (SFI) and €3.7m (industrial partners)
2003-2006: Wellcome Trust Project Grant: Characterization of IHG-1, a novel diabetic nephroropathy-associated gene product, which amplifies TGF- induced signalling
2003-2006: Irish Research Council for Science Engineering and Technology PhD Project Grant: Resolving Inflammation through Endogenous Mediators: An investigation of the potential of lipoxin receptor agonists to stimulate macrophage phagocytosis of apoptotic cells
2002-2005: Health Research Board Project Grant: Antifibrotic potential of lipoxins in renal disease.
2002-2007: Health Research Board Program Grant: Lipoxins, lipid-derived mediators that promote the resolution of inflammation
2001-2004: Health Research Board Project Grant: Functional proteomics of lipoxin-stimulated macrophages.
2000-2003: Health Research Project Grant: Leukotriene, lipoxin and PDGF receptor cross talk in renal mesangial cells.
2001-2002 Mater College Grant: Macrophage transcriptional responses in inflammation
2000-2001: Mater College Grant: Differential gene expression in glomerular hypertension
1999-2002: Health Research Board Project Grant: Lipoxin-induced gene expression in macrophages.
1998-2001: Health Research Board Project Grant: Cloning and characterization of endothelial lipoxin receptors.
1998: UCD President's Research Award.
1998: Health Research Board -Wellcome Trust Equipment Grant.


Sponsor for fellowships:

2004-2007: Health Research Board Postdoctoral Fellowship to Dr. Rosemary Kane: The role of the BMP-4 antagonist ventroptin in diabetic retinopathy
2001-2004: Health Research Board Postdoctoral Fellowship to Dr John Crean: CTGF as a therapeutic target in diabetic nephropathy.
1998-2000: Health Research Board Clinical Research Fellowship to Dr. Michael Clarkson: Expression of the lipoxin A4 receptor in experimental and human glomerulonephritis
1998; 1999,2000,2001 Health Research Board Summer Student Scholarships


Coinvestigator on the following grants:

2005-2008 Science Foundation Ireland Research Frontiers Programme
2004-2009 EU Framework 6: Eicosanox Programme Grant; Work Programme Leader
2004-2007 Science Foundation Ireland Research Frontiers Programme: Mechanisms of M. tuberculosis-induced macrophage apoptosis in the host response.
2000: Health Research Board Equipment Grant.
2000-2002 Conway Institute Postdoctoral Fellowship. Differential gene expression in fibrosis and unilateral ureteric obstruction
2000-2002: Conway Institute Postdoctoral Fellowship. Thromboxane-Lipoxin Receptor cross-talk in renal mesangial cells.
2000-2002 Conway Institute Postdoctoral Fellowship. TGF- signal transduction via the SMAD family.
1999-2002: Wellcome Trust Project Grant 'Lipoxin biosynthesis and bioactions in glomerulonephritis'.
1999-2001: Enterprise Ireland Strategic Grant. ‘Identification of Novel Diagnostic Markers and Therapeutic Targets by Suppression Subtractive Hybridisation'.
1997-2000: Health Research Board Unit Grant - Differential Gene Expression in Diabetic Glomerulosclerosis
1998: Health Research Board Equipment Grant.
1998-2000: Enterprise Ireland Strategic Grant: 'Pre-clinical development of a novel class of anti-inflammatory drugs based on synthetic lipoxin analogues'
1998-2002: EU Concerted Action Grant: Chronic inflammation leading to scarring, the major mechanism for kidney failure

Research Projects

Sponsor : Scios Nova Inc, USA
Title : No Project title to migrate.
Start Date / End Date : 01-JUN-97 / 09-AUG-97
Sponsor : Health Research Board (HRB)
Title : No Project title to migrate.
Start Date / End Date : 01-OCT-98 / 31-OCT-01
Sponsor : Health Research Board (HRB)
Title : No Project title to migrate.
Start Date / End Date : 01-JUL-98 / 01-JUL-20
Sponsor : Centre for Molecular Inflammation & Vascular Research Ltd
Title : The suppressors of Cytokine Signaling (SOCS) proteins as an Endogenous Regulators or Inflammation and Host Defence
Start Date / End Date : 01-OCT-98 / 30-OCT-01
Sponsor : Centre for Molecular Inflammation & Vascular Research Ltd
Title : Lipoxin-stimulated phagocytosis of apoptotic neutrophils by macrophage
Start Date / End Date : 01-OCT-98 / 30-OCT-01
Sponsor : Irish Heart Foundation
Title : Lipoxin modulation of tissue factor gene expression
Start Date / End Date : 01-JAN-99 / 31-DEC-99
Sponsor : Health Research Board (HRB)
Title : Diabetic Nephropathy Research Unit Equipment Grant
Start Date / End Date : 01-JAN-99 / 31-JAN-99
Sponsor : Health Research Board (HRB)
Title : Identification of susceptibility genes for progressive renal disease by combined differential gene expression, gene association and genetic linkage approaches
Start Date / End Date : 01-OCT-99 / 30-SEP-02
Sponsor : Health Research Board (HRB)
Title : Lipoxin mediated gene expression in macrophages
Start Date / End Date : 01-OCT-99 / 30-SEP-02
Sponsor : Health Research Board (HRB)
Title : Molecular Basis for Glomerulosclerosis in Diabetic Nephropathy
Start Date / End Date : 01-OCT-97 / 30-SEP-01
Sponsor : The Wellcome Trust (WT)
Title : Lipoxins: Lipid mediators that promote resolution of glomerulonephritis and other inflammatory diseases
Start Date / End Date : 01-DEC-99 / 01-NOV-03
Sponsor : Health Research Board (HRB)
Title : Lipoxin, Leukotriene and PDGF receptor crorss-talk in renal mesangial cells
Start Date / End Date : 01-OCT-00 / 30-SEP-03
Sponsor : Health Research Board (HRB)
Title : Hypoxia Dual Chamber System
Start Date / End Date : 01-NOV-00 / 08-NOV-00
Sponsor : Higher Education Authority (HEA)
Title : Research Unit 1 - project 2 (Dr. Geraldine McCarthy)
Start Date / End Date : 01-NOV-00 / 31-OCT-03
Sponsor : Higher Education Authority (HEA)
Title : Research Unit 2 Project 1 Lipoxin
Start Date / End Date : 01-NOV-00 / 31-OCT-03
Sponsor : Higher Education Authority (HEA)
Title : Research Unit 4 Project 1 Polymorphisins
Start Date / End Date : 01-NOV-00 / 31-OCT-03
Sponsor : Higher Education Authority (HEA)
Title : Research Unit 4 - project 3 Proteomics
Start Date / End Date : 01-NOV-00 / 31-OCT-03
Sponsor : Health Research Board (HRB)
Title : Microinjection equipment
Start Date / End Date : 01-FEB-01 / 31-JAN-02
Sponsor : Health Research Board (HRB)
Title : Evaluation of the therapeutic potential and mechanisms of action of the Lipoxins in experimental ischaemic acute renal failure with special emphasis on tubule epithelial cell transcriptemic responses.
Start Date / End Date : 01-JUL-01 / 03-JUN-03
Sponsor : Health Research Board (HRB)
Title : Connective tissue growth factor: a putative therapeutic target in Type 1 diabetes over a period of three years.
Start Date / End Date : 01-JUL-01 / 30-JUN-02
Sponsor : Health Research Board (HRB)
Title : Functional proteomics of lipocin - stimulated macroimages
Start Date / End Date : 01-OCT-01 / 30-SEP-04
Sponsor : Health Research Board (HRB)
Title : Lipoxins: Lipid-derived mediators that promote resolution of Inflammation.
Start Date / End Date : 01-JUL-02 / 01-OCT-07
Sponsor : Health Research Board (HRB)
Title : Identification of molecular drivers of diabetic athenosclenosis through complementary analysis of differential gene expression in vascular smooth muscle cells.
Start Date / End Date : 01-JUL-02 / 30-JUN-04
Sponsor : Health Research Board (HRB)
Title : An investigation of the potential antifibrotic actions of lipoxins in renal cells
Start Date / End Date : 01-OCT-02 / 30-SEP-05
Sponsor : Irish Research Council for Science Engineering and Technology (IRCSET)
Title : Annexun - 1 stimulated phagocytosis
Start Date / End Date : 01-OCT-03 / 31-MAR-07
Sponsor : Atlantic Philanthropies, USA
Title : Funding for Dr. Peter Doran (Bioinformatics and Human Genomics Unit)
Start Date / End Date : 01-SEP-03 / 30-AUG-08
Sponsor : Health Research Board (HRB)
Title : The role of ventroptin, a BMP antagonist, in diabetic retinopathy
Start Date / End Date : 01-OCT-04 / 30-SEP-07
Sponsor : Science Foundation Ireland (SFI)
Title : Ulysses Inaugural Medal (Dr. Phillip Sharp)
Start Date / End Date : 10-MAR-05 / 11-MAR-05
Sponsor : Science Foundation Ireland (SFI)
Title : Women in Irish Science and Engineering Research Institute Planning Grant
Start Date / End Date : 29-JUN-05 / 29-SEP-05
Sponsor : European Commission FP6
Title : Eicosanoids and Nitric Oxide: Mediators of Cardiovascular, Cerebral & Neoplastic Diseases (EICOSANOX)
Start Date / End Date : 01-FEB-05 / 31-JAN-10
Sponsor : Science Foundation Ireland (SFI)
Title : The molecular mechanisms underlying the initiation progression and potential regression of diabetic kidney disease
Start Date / End Date : 01-MAR-07 / 31-JAN-14
Sponsor : Irish Research Council for Science Engineering and Technology (IRCSET)
Title : Lipoxins: modulators of diabetic kidney disease?
Start Date / End Date : 01-OCT-07 / 30-SEP-10
Sponsor : HEA/PRTLI Cycle 4 Grant
Title : Biomedical Sciences Network
Start Date / End Date : 01-JUL-08 / 30-JUN-11
Sponsor : Science Foundation Ireland (SFI)
Title : Genome-Wide Association Studies of Diabetic Nephropathy
Start Date / End Date : 01-OCT-08 / 31-DEC-08
Sponsor : University College Dublin (UCD)
Title : Top-up funding
Start Date / End Date : 01-JUL-08 / 30-JUN-11
Sponsor : Science Foundation Ireland (SFI)
Title : In vitro transgenic models of renal diseas
Start Date / End Date : 01-MAR-08 / 28-FEB-09
Sponsor : Science Foundation Ireland (SFI)
Title : Micro-RNA Regulation of Gene Expression in Diabetic Nephropathy
Start Date / End Date : 01-JAN-09 / 31-DEC-09
Sponsor : Bayer Schering Pharma AG, Germany
Title : Mechanism of action of LX analogues
Start Date / End Date : 01-MAR-09 / 30-JUN-09
Sponsor : Science Foundation Ireland (SFI)
Title : Genome-Wide Association Studies of Diabetic Nephropathy
Start Date / End Date : 01-SEP-09 / 30-NOV-14
Sponsor : Compugen Ltd
Title : Efficiency and potency of two peptides in in vitro assays in human macrophages
Start Date / End Date : 15-JUN-09 / 15-OCT-09
Sponsor : Health Research Board (HRB)
Title : Investigation of the role of ROS in the regulation and function of IHG-1, a novel mediator of fibrosis
Start Date / End Date : 01-NOV-09 / 30-APR-13
Sponsor : Health Research Board (HRB)
Title : An investigation of the potential of lipoxin A4 and novel synthetic lipoxin of inflammatory arthritis
Start Date / End Date : 01-OCT-09 / 01-MAR-12
Sponsor : Irish Research Council for Science Engineering and Technology (IRCSET)
Title : Diabetic complications: a failure to resolve inflammation?
Start Date / End Date : 01-OCT-09 / 30-SEP-12
Sponsor : Boehringer Ingelheim Pharmaceuticals Inc
Title : Boehringer Ingelheim Pharmaceuticals Inc Research Project
Start Date / End Date : 01-NOV-09 / 30-NOV-10
Sponsor : The Wellcome Trust (WT)
Title : Biomedical Vacation Scholarship for Daniel Regan-Komito
Start Date / End Date : 21-JUN-10 / 20-AUG-10
Sponsor : University College Dublin Foundation Ltd.
Title : Gremlin in renal fibrosis
Start Date / End Date : 01-SEP-09 / 30-AUG-10
Sponsor : Higher Education Authority (HEA)
Title : Biomedical Sciences Network
Start Date / End Date : 01-OCT-09 / 31-MAR-12
Sponsor : F. Hoffmann-La Roche Ltd.
Title : The effect of Roche compounds in in vitro and in vivo models of fibrosis
Start Date / End Date : 01-FEB-11 / 31-OCT-11
Sponsor : EC Framework (FP7)
Title : Solving CKD ¿ Protecting against obesity-induced chronic kidney disease using pro-resolving lipids
Start Date / End Date : 01-JUL-12 / 30-JUN-15
Sponsor : F. Hoffmann-La Roche Ltd.
Title : Fibrosis: Organ Damage/Organ Repair: Getting the Balance Right
Start Date / End Date : 04-FEB-13 / 30-JAN-15
Sponsor : Massachusetts General Hospital
Title : JDRF Diabetic kidney disease- "A cross-sectional search for genetic determinants of diabetic nephrology"
Start Date / End Date : 01-SEP-12 / 31-AUG-15
Sponsor : University College Dublin (UCD)
Title : Chronic kidney diseases
Start Date / End Date : 01-MAY-13 / 29-MAY-15
Sponsor : Georgia Health Sciences University
Title : Functional role of candidate genes emerging from GWAS in diabetic nephropathy
Start Date / End Date : 01-JAN-13 / 31-DEC-14
Sponsor : Enterprise Ireland (EI)
Title : Travel to H2020 Partners
Start Date / End Date : 05-AUG-14 / 04-FEB-15
Sponsor : The Wellcome Trust (WT)
Title : Potential renoprotective role of incretin-based drugs in models of diabetic nephropathy
Start Date / End Date : 02-JUN-15 / 27-JUL-15
Sponsor : Science Foundation Ireland (SFI)
Title : Asymmetric Synthesis and Biological Evaluation of Lipoxin Analogues and Tetrahydrofuran Derivatives
Start Date / End Date : 01-APR-12 / 01-APR-17
Sponsor : Higher Education Authority (HEA)
Title : PRTLI 5: MMI
Start Date / End Date : 01-MAR-11 / 30-SEP-16
Sponsor : Irish Research Council (IRC)
Title : Exploration of exosomal biomarkers and micro-RNA therapeutics in complications of Diabetes
Start Date / End Date : 01-JAN-14 / 31-DEC-16
Sponsor : University College Dublin (UCD)
Title : School Funded Research Account
Start Date / End Date : 01-JUL-14 / 30-JUN-16

Recent Postgraduates

Blaithin McMahon PhD - Liposxin A4 and leukotriene D4 receptors in the regulation of glomerular inflammation 2002
Siobhan Mitchell PhD - Lipoxin mediated macrophage phagocytosis in the resolution of inflammation 2002
David Lappin PhD - A functional genomics investigation of diabetic nephropathy 2003
Michael Clarkson MD - Actin cytoskeletal dysfunction in the pathogenesis of diabetic nephropathy 2004
Derick Mitchell PhD - Receptor cross talk in the regulation of mesangial cell function 2004
Keira Reville PhD - Molecular mechganisms regulating lipoxin-stimulated phagocytosis of apoptotic leukocytes 2005
Susan Connolly PhD - An integrated functional genomics and bioinformativc approach to the study of cardiovascular disease 2005
Eoin Cummins PhD - Novel insights into NF-kB mediated responses to hypoxia 2007
Karen Rodgers PhD - Anti fibrotic actions of lipoxins in models of renal disease 2007
Michael Scannell PhD- Pleiotropic lipoxin receptor agonists and the reolution of inflammation 2007
Jayesh Kattla PhD- Molecular mechanisms of tubulointerstitial fibrosis in diabetic nephropathy 2007
Yann Decker- expected completion Summer 2008
Emma Borgeson- expected completion Autumn 2010
Aidan Ryan- expected completion Autumn 2010

 

Collaborators

Internal Collaborators

Professor Finian Martin
Conway Institute, UCD
http://www.ucd.ie/conway/cv_64.html


Professor Pat Guiry
CSCB, UCD

Prof.  Cormac Taylor
Conway Institute, UCD
http://www.ucd.ie/conway/cv_38.html

External Collaborators

Prof Mauro Perretti
William Harvey Research Institute
London

Prof AP Maxwell
Queens University
Belfast
N Ireland

Dr James Tobin

Cardiovascular and Metabolic Diseases

Wyeth

Cambridge, MA


Dr Jesper Haeggesstrom

Karolinska Institute

Stockholm

Sweden
Dr David Savage
Queens University
Belfast
N Ireland


Dr Jim Tobin
Cardiovascular and Metabolic Disease
Wyeth
Cambridge MA

Dr Ji-Ming Wang
Chemokine Receptor Lab
NCI
Fredricksburg, MD 

Dr Joel Hirschhorn and Dr Jose Flores
Broad Institute
MIT
Boston, MA