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Researchers at UCD

researcher

Colm O'Brien

Professor of Ophthalmology

School Of Medicine
Mater Hospital
Eccles Street
Dublin 7

Tel:
Email: cobrien@mater.ie

Biography

Research interests in the mechanisms and treatment of glaucoma, including optic nerve/lamina cribrosa/trabecular meshwork ECM accumulation/fibrosis, focusing in particular on abnormal calcium homeostasis, mitochondrial dysfunction and oxidative stress.

 

The group is also investigating macular pigment function/structure and function, and quality of life issues in glaucoma.

 

Achievements: Chairman of the Glaucoma Programme Committee, ARVO, Seattle 2012-13

 

Symposium Organiser/Moderator:

1.       Fibrosis in Glaucoma, ARVO Annual Meeting, Seattle May 2013

2.       Update on glaucoma GWAS studies, UK & Eire Glaucoma Society Annual Meeting, Nottingham, December 2013

Professional

           

Committees

Committee : National Council for the Blind of Ireland
Committee : Fighting Blindness Ireland, Scientific Advisory Board
Committee : Drug Safety Committee, Mater Misericordiae University Hospital
Committee : UK & Eire Glaucoma Society Committee
           

Other Activities

Orbis Volunteer, China 2006

Publications

Books

Wilson, S.J. and Rankin, S.J.A. and O'Brien, C. and Delaney, Y. (2007) Diagnosis of glaucoma through examination of the optic nerve head. : Elsevier Ltd. [DOI] [Details]

Book Chapters

S Wilson, S J A Rankin, C O'Brien, Y Delaney; (2007) 'Diagnosis of glaucoma through examination of the optic nerve head' In: D F Edgar, A Rudnicka (eds). Glaucoma Co-Management. London: Butterworth-Heinemann Limited. [Details]
C O'Brien, E Henry; (1999) 'Anti-Glaucoma Drugs' In: D Easty, J Sparrow (eds). Oxford Textbook of Ophthalmology. Oxford: Oxford University Press. [Details]
C O'Brien; (1999) 'Management of Glaucoma' In: D Easty, J Sparrow (eds). Oxford Textbook of Ophthalmology. Oxford: Oxford University Press. [Details]
C O'Brien, A Harris; (1999) 'Optic Nerve Blood Flow Measurement' In: M Yanoff, J Duker (eds). Ophthalmology. London: C V Mosby. [Details]
C O'Brien, J Diamond; (1999) 'Primary Open Angle Glaucoma' In: C O'Brien, J Diamond; (eds). Clinical Evidence. London: BMJ Publishing Group. [Details]
 

Peer Reviewed Journals

McDonnell F, Irnaten M;Clark AF;O'Brien CJ;Wallace DM (2016) 'Hypoxia-Induced Changes in DNA Methylation Alter RASAL1 and TGF¿¿1 Expression in Human Trabecular Meshwork Cells'. PLoS ONE, 11 (4). [DOI] [Details]
Siah WF, Loughman J;O'Brien C (2015) 'Lower Macular Pigment Optical Density in Foveal-Involved Glaucoma'. Ophthalmology, 122 (10):2029-2037. [DOI] [Details]
Wallace DM, O'Brien CJ (2015) 'The role of lamina cribrosa cells in optic nerve head fibrosis in glaucoma'. Experimental Eye Research, 142 :102-109. [DOI] [Details]
Treacy MP, O'Neill EC;Murphy M;O'Toole L;Delaney Y;O'Brien C;Connell PP (2015) 'Opportunistic detection of glaucomatous optic discs within a diabetic retinopathy screening service'. European Journal of Ophthalmology, . [DOI] [Details]
Sundaresan P, Simpson DA;Sambare C;Duffy S;Lechner J;Dastane A;Dervan EW;Vallabh N;Chelerkar V;Deshpande M;O'Brien C;McKnight AJ;Willoughby CE (2015) 'Whole-mitochondrial genome sequencing in primary open-angle glaucoma using massively parallel sequencing identifies novel and known pathogenic variants'. Genetics in Medicine, 17 (4):279-284. [DOI] [Details]
Murphy RM, Bakir B;O'Brien C;Wiggs JL;Pasquale LR (2015) 'Drug-induced Bilateral Secondary Angle-Closure Glaucoma: A Literature Synthesis'. Journal of Glaucoma, . [DOI] [Details]
Quill B, Irnaten M;Docherty NG;McElnea EM;Wallace DM;Clark AF;O'Brien CJ (2015) 'Calcium channel blockade reduces mechanical strain-induced extracellular matrix gene response in lamina cribrosa cells'. British Journal of Ophthalmology, 99 (7):1009-1014. [DOI] [Details]
Wallace DM, Pokrovskaya O;O'Brien CJ (2015) 'The Function of Matricellular Proteins in the Lamina Cribrosa and Trabecular Meshwork in Glaucoma'. Journal of Ocular Pharmacology and Therapeutics, 31 (7):386-395. [DOI] [Details]
McElnea EM, Hughes E;McGoldrick A;McCann A;Quill B;Docherty N;Irnaten M;Farrell M;Clark AF;O'Brien CJ;Wallace DM (2014) 'Lipofuscin accumulation and autophagy in glaucomatous human lamina cribrosa cells'. BMC Ophthalmology, 14 . [DOI] [Details]
McDonnell F, O'Brien C;Wallace D (2014) 'The role of epigenetics in the fibrotic processes associated with glaucoma'. Ophthalmology, 2014 . [DOI] [Details]
Gao W, Ferguson G;Connell P;Walshe T;O'Brien C;Redmond EM;Cahill PA (2014) 'Glucose attenuates hypoxia-induced changes in endothelial cell growth by inhibiting HIF-1¿¿ expression'. Diabetes and Vascular Disease Research, 11 (4):270-280. [DOI] [Details]
Wallace DM, Murphy-Ullrich JE;Downs JC;O'Brien CJ (2014) 'The role of matricellular proteins in glaucoma'. Matrix Biology, 37 :174-182. [DOI] [Details]
McNally S, O'Brien CJ (2014) 'Metabolomics/Proteomics strategies used to identify biomarkers for exfoliation glaucoma'. Journal of Glaucoma, 23 (8 Suppl 1):1-4. [DOI] [Details]
Irnaten M, Barry RC, Wallace DM, Docherty NG, Quill B, Clark AF, O'Brien CJ (2013) 'Elevated maxi-K(+) ion channel current in glaucomatous lamina cribrosa cells'. Eye, 115 :224-229. [DOI] [Details]
Wallace DM, Clark AF;Lipson KE;Andrews D;Crean JK;O'Brien CJ (2013) 'Anti-connective tissue growth factor antibody treatment reduces extracellular matrix production in trabecular meshwork and lamina cribrosa cells'. Investigative Ophthalmology and Visual Science, 54 (13):7836-7848. [DOI] [Details]
Igras E, Loughman J;Ratzlaff M;O'Caoimh R;O'Brien C (2013) 'Evidence of lower macular pigment optical density in chronic open angle glaucoma'. British Journal of Ophthalmology, 97 (8):994-998. [DOI] [Details]
Wiggs, JL,Hewitt, AW,Fan, BJ,Wang, DY,Sena, DRF,O'Brien, C,Realini, A,Craig, JE,Dimasi, DP,Mackey, DA,Haines, JL,Pasquale, LR (2012) 'The p53 Codon 72 PRO/PRO Genotype May Be Associated with Initial Central Visual Field Defects in Caucasians with Primary Open Angle Glaucoma'. PLoS ONE, 7 . [DOI] [Details]
Kirwan RP, Felice L;Clark AF;O'Brien CJ;Leonard MO (2012) 'Hypoxia regulated gene transcription in human optic nerve lamina cribrosa cells in culture'. Investigative Ophthalmology and Visual Science, 53 (4):2243-2255. [DOI] [Details]
Quill B, Docherty N, Clark AF, O'Brien CJ; (2011) 'The Effect of Graded Cyclic Stretch on Extracellular Matrix Related Gene Expression Profiles in Cultured Primary Human Lamina Cribrosa Cells'. Investigative Ophtalmology and Visual Science, 30 (52):1908-1915. [Details]
Farrell, SMJ,Groeger, G,Bhatt, L,Finnegan, S,O'Brien, CJ,Cotter, TG; (2011) 'bFGF-mediated redox activation of the PI3K/Akt pathway in retinal photoreceptor cells'. European Journal of Neuroscience, 33 :632-641. [DOI] [Details]
Browne, JG,Ho, SL,Kane, R,Oliver, N,Clark, AF,O'Brien, CJ,Crean, JK; (2011) 'Connective Tissue Growth Factor Is Increased in Pseudoexfoliation Glaucoma'. Science, 52 :3660-3666. [DOI] [Details]
Guerin, MB,Donovan, M,McKernan, DP,O'Brien, CJ,Cotter, TG; (2011) 'Age-dependent rat retinal ganglion cell susceptibility to apoptotic stimuli: implications for glaucoma'. Ophthalmology, 39 :243-251. [DOI] [Details]
McElnea, EM,Quill, B,Docherty, NG,Irnaten, M,Siah, WF,Clark, AF,O'Brien, CJ,Wallace, DM; (2011) 'Oxidative stress, mitochondrial dysfunction and calcium overload in human lamina cribrosa cells from glaucoma donors'. Molecular Vision, 17 :1182-1191. [Details]
Gallagher, BAM,Hart, PM,O'Brien, C,Stevenson, MR,Jackson, AJ; (2011) 'Mobility and access to transport issues as experienced by people with vision impairment living in urban and rural Ireland'. Disability and Rehabilitation, 33 :979-988. [DOI] [Details]
Walshe TE, Connell P, Cryan L, Ferguson G, Gardiner T, Morrow D, Redmond EM, O'Brien C, Cahill PA.; (2011) 'Microvascular retinal endothelial and pericyte cell apoptosis in vitro: role of Hedgehog and Notch signaling'. Investigative Ophtalmology and Visual Science, 23 (52):4472-4483. [Details]
Walshe TE, Connell P, Cryan L, Ferguson G, O'Brien C, Cahill PA; (2011) 'The role of pulsatile flow in controlling microvascular retinal endothelial and pericyte cell apoptosis and proliferation'. Investigative Ophtalmology and Visual Science, 15 (89):661-670. [Details]
Peirce C, O¿Brien C, O¿Herlihy C.; (2010) 'Postpartum femoral neuropathy following spontaneous vaginal delivery'. Journal of obstetrics and gynaecology: the journal of the Institute of Obstetrics and Gynaecology (J Obstet Gynaecol), 30 :203-204. [Details]
Dervan, EW,Chen, H,Ho, SL,Brummel, N,Schmid, J,Toomey, D,Haralambova, M,Gould, E,Wallace, DM,Prehn, JHM,O'Brien, CJ,Murphy, D; (2010) 'Protein Macroarray Profiling of Serum Autoantibodies in Pseudoexfoliation Glaucoma'. Investigative Ophthalmology Visual Science, 51 :2968-2975. [DOI] [Details]
O'Connor, R,Cryan, LM,Wynne, K,de Stefani, A,Fitzgerald, D,O'Brien, C,Cagney, G; (2010) 'Proteomics Strategy for Identifying Candidate Bioactive Proteins in Complex Mixtures: Application to the Platelet Releasate'. Journal of Biomedicine and Biotechnology, . [DOI] [Details]
Quaranta L, Konstas AG, Rossetti L, Garcia-Feijoo J, O'Brien C, Nasr MB, Fogagnolo P, Demos CM, Stewart JA, Stewart WC; (2010) 'Untreated 24-h intraocular pressures measured with Goldmann applanation tonometry vs nighttime supine pressures with Perkins applanation tonometry'. Eye, 24 (7):1252-1258. [Details]
Browne, JG., Ho, SL., Kadare, SJ., Kane, R., Oliver, N., Clark, AF., O'Brien, CJ., Crean, JK. ; (2010) 'The Effect Of CTGF On Trabecular Meshwork Cells And The Implications For Pseudoexfoliative Syndrome'. IOVS, . [Details]
Kirwan, RP,Wordinger, RJ,Clark, AF,O'Brien, CJ; (2009) 'Differential global and extra-cellular matrix focused gene expression patterns between normal and glaucomatous human lamina cribrosa cells'. Molecular Vision, 15 :76-88. [Details]
Cryan, LM,Fitzgerald, DJ,O'Brien, C; (2009) 'Ocular prostaglandin production and morphology in mice lacking a single isoform of cyclooxygenase'. Prostaglandins Leukotrienes and Essential Fatty Acids, 81 :401-409. [DOI] [Details]
Irnaten, M,Barry, RC,Quill, B,Clark, AF,Harvey, BJP,O'Brien, CJ; (2009) 'Activation of Stretch-Activated Channels and Maxi-K+ Channels by Membrane Stress of Human Lamina Cribrosa Cells'. Investigative Ophthalmology Visual Science, 50 :194-202. [DOI] [Details]
O'Connor, JC,Wallace, DM,O'Brien, CJ,Cotter, TG; (2008) 'A novel antioxidant function for the tumor-suppressor gene p53 in the retinal ganglion cell'. Investigative Ophthalmology Visual Science, 49 :4237-4244. [DOI] [Details]
O'Brien C, Irnaten M, Barry RC, Quill B, Clark AF, Harvey B, ; (2008) 'Membrane Stress Of Human Lamina Cribrosa Cells Activates Stretch Activated Channels and Maxi K+ Channels'. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, . [DOI] [Details]
Cryan, LM,Paraoan, L,Hiscott, P,Damato, BE,Grierson, I,Gray, D,Farrell, M,Doherty, GA,Fitzgerald, DJ,O'Brien, C; (2008) 'Expression of COX-2 and prognostic outcome in uveal melanoma'. Current Eye Research, 33 (NA):177-184. [DOI] [Details]
O'Brien C et al; (2008) 'Evaluation of LOX1 gene polymorphisms in exfoliation syndrome and exfoliation glaucoma'. Molecular Vision, 17 (14):533-541. [Details]
O'Driscoll, C,O'Connor, J,O'Brien, CJ,Cotter, TG; (2008) 'Basic fibroblast growth factor-induced protection from light damage in the mouse retina in vivo'. Journal of Neurochemistry, 105 :524-536. [DOI] [Details]
Kane, R,Godson, C,O'Brien, C; (2008) 'Chordin-like 1, a bone morphogenetic protein-4 antagonist, is upregulated by hypoxia in human retinal pericytes and plays a role in regulating angiogenesis'. Molecular Vision, 14 :1138-1148. [Details]
O'Brien, C., Polakova, M., Pitt, N., Tosin, M., Murphy, P.V., ; (2007) 'Glycosidation-anomerisation reactions of 6,1-anhydroglucopyranuronic acid and anomerisation of beta-D-glucopyranosiduronic acids promoted by SnCl4'. CHEMISTRY-A EUROPEAN JOURNAL, 13 (3):902-909. [Details]
Lee H, O'Meara S, O'Brien C, Kane R.; (2007) 'The role of gremlin, a BMP antagonist, and epithelial to mesenchymal transition in proliferative vitreoretinopathy'. Investigative Ophtalmology and Visual Science, 48 (9):4291-4299. [Details]
Horgan, N.,Kirwan, R. P.,O'Brien, C. J.; (2007) 'Choroidal detachment associated with latanoprost use in the fellow eye'. Ann Pharmacother, 41 (1):161-2. [Details]
Cotter TG, McKernan DP, Guerin MB, O'Brien CJ, ; (2007) 'A key role for calpains in retinal ganglion cell death'. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 48 (12):5420-5430. [DOI] [Details]
Cahill PA, Gao W, Ferguson G, Connell P, Walshe T, Murphy R, Birney YA, O'Brien C, ; (2007) 'High glucose concentrations alter hypoxia-induced control of vascular smooth muscle cell growth via a HIF-1alpha-dependent pathway'. Journal Molecular Cell Cardiology, 42 (3):609-619. [DOI] [Details]
Cahill PA, Connell P, Walshe T, Ferguson G, Gao W, O'Brien C, ; (2007) 'Elevated glucose attenuates agonist- and flow-stimulated endothelial nitric oxide synthase activity in microvascular retinal endothelial cells'. Endothelium: Journal of Endothelial Cell Research, 14 (1):17-24. [DOI] [Details]
Mahony R, O'Brien C, Kinsley B, Firth R, Coffey M, O'Connell R, O'Herlihy C; (2007) 'Antepartum pudendal neuropathy and the effect of vaginal delivery in women with type 1 diabetes mellitus'. International Journal of Diabetes and Metabolism, . [Details]
McKernan, DP,Caplis, C,Donovan, M,O'Brien, CJ,Cotter, TG; (2006) 'Age-dependent susceptibility of the retinal ganglion cell layer to cell death'. Investigative Ophthalmology Visual Science, 47 :807-814. [DOI] [Details]
Kelliher, C; Kenny, D; O'Brien, C; ; (2006) 'Trends in blind registration in the adult population of the Republic of Ireland 1996-2003'. British Journal of Ophthalmology, 90 (3):367-371. [Details]
Guerin, MB; McKernan, DP; O'Brien, CJ; Cotter, TG; ; (2006) 'Retinal ganglion cells: dying to survive'. International Journal of Developmental Biology, 50 (8):665-674. [Details]
Delaney, Y; Walshe, TE; O'Brien, C; ; (2006) 'Vasospasm in glaucoma: Clinical and laboratory aspects'. Optometry and Vision Science, 83 (7):406-414. [Details]
Knox, F. A.,Barry, M.,McGowan, B.,O'Brien, C.; (2006) 'The rising cost of glaucoma drugs in Ireland 1996-2003'. Br J Ophthalmol, 90 (2):162-5. [Details]
Henry, E.,Newby, D. E.,Webb, D. J.,Hadoke, P. W.,O'Brien, C. J.; (2006) 'Altered endothelin-1 vasoreactivity in patients with untreated normal-pressure glaucoma'. Invest Ophthalmol Vis Sci, 47 (6):2528-32. [Details]
Greene BR, de Chazal P, Boylan G, Reilly RB, O'Brien C, Connolly S. ; (2006) 'Heart and respiration rate changes in the neonate during electroencephalographic seizure'. Medical and Biological Engineering and Computing, 44 (1-2):27-34. [Details]
Cryan, L,Pidgeon, G,Fitzgerald, D,O'Brien, C; (2006) 'COX-2 protects against thrombosis of the retinal vasculature in a mouse model of proliferative retinopathy'. Molecular Vision, 12 :405-414. [Details]
Browne, JG, Kane, R, Godson, C, Cotter, TG, O'Brien, CJ, ; (2005) 'Glucose induction of apoptosis in human retinal pericytes'. Investigative Ophthalmology Visual Science, 46 (NA). [Details]
Kane, R; Stevenson, L; Godson, C; Stitt, AW; O'Brien, C; ; (2005) 'Gremlin gene expression in bovine retinal pericytes exposed to elevated glucose'. British Journal of Ophthalmology, 89 (12):1638-1642. [Details]
Kirwan, RP; Fenerty, CH; Crean, J; Wordinger, RJ; Clark, AF; O'Brien, CJ; ; (2005) 'Influence of cyclical mechanical strain on extracellular matrix gene expression in human lamina cribrosa cells in vitro'. Molecular Vision, 11 (94-96):798-810. [Details]
Cleary, C; Buckley, CH; Henry, E; McLoughlin, P; O'Brien, C; Hadoke, PWF; ; (2005) 'Enhanced endothelium derived hyperpolarising factor activity in resistance arteries from normal pressure glaucoma patients: implications for vascular function in the eye'. British Journal of Ophthalmology, 89 (2):223-228. [Details]
Ho, SL; Dogar, GF; Wang, J; Crean, J; Wu, QD; Oliver, N; Weitz, S; Murray, A; Cleary, PE; O'Brien, C; ; (2005) 'Elevated aqueous humour tissue inhibitor of matrix metalloproteinase-1 and connective tissue growth factor in pseudoexfoliation syndrome'. British Journal of Ophthalmology, 89 (2):169-173. [Details]
O'Brien CJ, Long VW, ; (2005) 'Trends in ophthalmic surgery in Ireland'. Irish Journal of Medical Science, 174 (2):36-39. [Details]
Cahill PA, Walshe TE, Ferguson G, Connell P, O'Brien C, ; (2005) 'Pulsatile flow increases the expression of eNOS, ET-1, and prostacyclin in a novel in vitro coculture model of the retinal vasculature'. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 46 (1):375-382. [DOI] [Details]
Kirwan, RP, Leonard, MO, Murphy, M, Clark, AF, O'Brien, CJ, ; (2005) 'Transforming growth factor-beta-regulated gene transcription and protein expression in human GFAP-negative lamina cribrosa cells'. Glia, 52 (4):309-324. [Details]
Crean JK, Kirwan R, Finerty C and OBrien C; (2004) 'Matrix metalloproteinase-2/type IV collagenase secretion in human lamina cribrosa cells is modulated by cyclical mechanical stretch and transforming growth factor-b1'. Journal of Glaucoma In Press . [Details]
Azuara-Blanco A, Morgan-Davies J, Taylor N, Hill AR, Aspinall P, O'Brien CJ, ; (2004) 'Three dimensional analysis of the lamina cribrosa in glaucoma'. British Journal of Ophthalmology, 88 (10):1299-1304. [DOI] [Details]
Shortt, AJ, Howell, K, O'Brien, C, McLoughlin, P, ; (2004) 'Chronic systemic hypoxia causes intra-retinal angiogenesis'. Journal of Anatomy, 205 (5):349-356. [DOI] [Details]
Kirwan, RP; Crean, JK; Fenerty, CH; Clark, AF; O'Brien, CJ; ; (2004) 'Effect of cyclical mechanical stretch and exogenous transforming growth factor-beta 1 on matrix metalloproteinase-2 activity in lamina cribrosa cells from the human optic nerve head'. Journal of Glaucoma, 13 (4):327-334. [Details]
Browne, JG; Kane, R; Godson, C; Cotter, TG; O'Brien, CJ; ; (2004) 'Mechanism of pericyte apoptosis following glucose exposure'. Investigative Ophthalmology Visual Science, 45 (NA):88-88. [Details]
Kirwan, C; Howell, K; O'Brien, CO; McLoughlin, P; ; (2004) 'The role of nitric oxide in angiogenesisin the globally hypoxic retina'. Investigative Ophthalmology Visual Science, 45 (NA):739-739. [Details]
Kirwan, RP; Crean, JK; Clark, A; O'Brien, CJ; ; (2004) 'The effect of transforming growth factor beta-1 (TGF-beta 1) on gene expression profiles in lamina cribrosa cells from the human optic nerve head'. Investigative Ophthalmology Visual Science, 45 (NA):408-408. [Details]
Shouldice, RB,O'Brien, LM,O'Brien, C,de Chazal, P,Gozal, D,Heneghan, C; (2004) 'Detection of obstructive sleep apnea in pediatric subjects using surface lead electrocardiogram features'. Sleep, 27 (NA):784-792. [Details]
O'Brien, C; O'Herlihy, C; O'Connell, PR; ; (2004) 'Pudendal neuropathy is best determined by full neurophysiologic assessment'. American Journal of Obstetrics and Gynecology, 191 (5):1836-1836. [Details]
Eogan, M; O'Brien, C; Carolan, D; Fynes, M; O'Herlihy, C; ; (2004) 'Median and ulnar nerve conduction in pregnancy'. International Journal of Gynecology Obstetrics, 87 (3):233-236. [Details]
Cryan, LM; Pidgeon, GP; Fitzgerald, DJ; O' Brien, C; ; (2004) 'COX-2 has a protective role in a mouse model of ischaemic retinopathy'. Investigative Ophthalmology Visual Science, 45 (NA):354-354. [Details]
Kirwan, RP; Crean, JK; Fenerty, C; Clark, AF; O'Brien, CJ; ; (2003) 'Differential gene expression in normal primary human lamina cribrosa cells exposed to cyclical mechanical stretch: A model for glaucomatous optic neuropathy'. Investigative Ophthalmology Visual Science, 44 (NA):295-295. [Details]
Andrew R, Stokes J, Walker BR, Campbell JC, Seckl JR, O'Brien C, ; (2003) 'Altered peripheral sensitivity to glucocorticoids in primary open-angle glaucoma'. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 44 (12):5163-5167. [Details]
O'Brien C, Kerr J, Nelson P, ; (2003) 'Pulsatile ocular blood flow in primary open-angle glaucoma and ocular hypertension'. American Journal of Ophthalmology, 136 (6):1106-1113. [Details]
O'Brien C, Nelson P, Aspinall P, Papasouliotis O, Worton B, ; (2003) 'Quality of life in glaucoma and its relationship with visual function'. Journal of Glaucoma, 12 (2):139-150. [Details]
Quinn, S, O'Brien, C, McLoughlin, P, ; (2003) 'Role of cyclooxygenase and haemoxygenase products in nitric oxide-independent vasodilatation in the porcine ciliary artery'. Eye, 17 (5):628-636. [DOI] [Details]
Ho, S; Crean, J; Oliver, N; Klaus, S; O'Brien, C; ; (2003) 'Elevated aqueous humour tissue inhibitor of matrix metalloproteinase-1 and connective tissue growth factor in pseudoexfoliation syndrome'. Investigative Ophthalmology Visual Science, 44 (NA):519-519. [Details]
Cryan, LM; Fitzgerald, DJ; O'Brien, C; ; (2003) 'Isoform specific disruption of the cyclooxygenase genes in oxygen-induced retinopathy'. Investigative Ophthalmology Visual Science, 44 (NA):77-77. [Details]
Kane, R; Godson, C; Brady, HR; O'Brien, C; ; (2003) 'Differential gene expression in human retinal pericytes in response to glucose and hypoxia'. Investigative Ophthalmology Visual Science, 44 (NA):395-395. [Details]
Chang, B; Madden, S; Doran, P; Kane, R; O'Brien, C; ; (2003) 'In silico gene identification of eye specific genes'. Investigative Ophthalmology Visual Science, 44 (NA):81-81. [Details]
Buckley, C; Hadoke, PWF; Henry, E; O'Brien, C; ; (2002) 'Systemic vascular endothelial cell dysfunction in normal pressure glaucoma'. British Journal of Ophthalmology, 86 (2):227-232. [Details]
O'Brien, CJ; Fenerty, CH; Crean, JKG; Clark, AF; ; (2001) 'Production of matrix metalloprotease-2 by glauomatous and non-glaucomatous optic nerve astrocytes'. Investigative Ophthalmology Visual Science, 42 (4):511-511. [Details]
O'Brien C, O'Toole L, Cahill M, ; (2001) 'Eyelid hypertrichosis associated with latanoprost is reversible'. European Journal of Ophthalmology, 11 (4):377-379. [Details]
Devlin, HC; Crean, J; Fenerty, C; Clark, AF; O'Brien, C; ; (2001) 'Effects of mechanical stretch on the expression of MMPs and TIMPs by trabecular meshwork cells'. Investigative Ophthalmology Visual Science, 42 (4):140-140. [Details]
O Brien C, Devlin H; (2001) 'Normal Tension Glaucoma; Diagnosis and Management'. CME journal of ophthalmology, 5 (1):13-17. [Details]
O'Brien CJ, King AJ, Bolton N, Aspinall P, ; (2000) 'Measurement of peripapillary retinal nerve fiber layer volume in glaucoma'. American Journal of Ophthalmology, 129 (5):599-607. [Details]
O'Brien CJ, Morgan-Davies J, King AJ, Aspinall P, ; (2000) 'Measurement of a novel optic disc topographic parameter, spikiness, in glaucoma'. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 238 (8):669-676. [Details]
Nelson P, MacKinnon JR, McKillop G, O'Brien C, Swa K, Butt Z, ; (2000) 'Colour Doppler imaging of the ocular circulation in diabetic retinopathy'. Acta Ophthalmologica Scandinavica, 78 (4):386-389. [Details]
Andrew R, Stokes J, Noble J, Brett L, Phillips C, Seckl JR, O'Brien C, ; (2000) 'Distribution of glucocorticoid and mineralocorticoid receptors and 11beta-hydroxysteroid dehydrogenases in human and rat ocular tissues'. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 41 (7):1629-1638. [Details]
O'Brien CJ, Edgar DF, Crabb DP, Rudnicka AR, Lawrenson JG, Guttridge NM, ; (1999) 'Effects of dipivefrin and pilocarpine on pupil diameter, automated perimetry and LogMAR acuity'. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 237 (2):117-124. [Details]
Butt Z, O'Brien C, ; (1999) 'Blood flow velocity in the peripheral circulation of glaucoma patients'. Ophthalmologica, 213 (3):150-153. [Details]
O'Brien C, Henry E, Newby DE, Webb DJ, ; (1999) 'Peripheral endothelial dysfunction in normal pressure glaucoma'. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 40 (8):1710-1714. [Details]
O'Brien C, Nelson P, Aspinall P, ; (1999) 'Patients' perception of visual impairment in glaucoma: a pilot study'. British Journal of Ophthalmology, 83 (5):546-552. [Details]
O'Brien CJ, Buckley CH, Hadoke PW, ; (1998) 'Role of the endothelium in modulating functional responses of isolated bovine anterior ciliary arteries to vasoconstrictor agonists'. British Journal of Ophthalmology, 82 (7):826-829. [Details]
O'Brien C, ; (1998) 'Is there a role for computerised image analysis in glaucoma management?'. British Journal of Ophthalmology, 82 (1):2-3. [Details]
O'Brien C, Kerr J, Nelson P, ; (1998) 'A comparison of ocular blood flow in untreated primary open-angle glaucoma and ocular hypertension'. American Journal of Ophthalmology, 126 (1):42-51. [Details]
O'Brien C, ; (1998) 'Vasospasm and glaucoma'. British Journal of Ophthalmology, 82 (8):855-856. [Details]
O'Brien C, Kelly PA, Buckley CH, Ritchie IM, ; (1998) 'Possible role for nitric oxide releasing nerves in the regulation of ocular blood flow in the rat'. British Journal of Ophthalmology, 82 (10):1199-1202. [Details]
Hitchings RA, Fontana L, Poinoosawmy D, Bunce CV, O'Brien C, ; (1998) 'Pulsatile ocular blood flow investigation in asymmetric normal tension glaucoma and normal subjects'. British Journal of Ophthalmology, 82 (7):731-736. [Details]

Other Journals

Greene, B.R., deChazal, P., Boylan, G, O'Brien, C., Reilly, R.B., Connolly, S.; (2006) 'Autonomic Changes in the Neonate during Seizure' Medical & Biological Engineering and Computing 44 (1, 2) :27-34. [Details]
O'Brien, C. and Heneghan, C. ; (2006) 'A comparison of algorithms for estimation of a respiratory signal from the surface electrocardiogram' Computers in Biology and Medicine Jun-06 :1-10. [Details]
R.B. Shouldice, L. M. O'Brien, C. O'Brien, P. de Chazal, D Gozal, C Heneghan; (2004) 'Detection of obstructive sleep apnea in pediatric subjects using surface lead electrocardiogram features' Sleep 27 :784-792. [Details]

Conference Publications

Andrews D, Browne J, O'Donovan H, Faherty N, Oliver N, Wallace D, O'Brien C and Crean J. (2012) Integrated signalling between CTGF and TGFβ2 leads to divergent activation of canonical and non-canonical pathways controlling EMT in ARPE-19 cells: Implications for the pathogenesis of proliferative vitreoretinopathy ARVO [Details]
O'Brien C, Cryan LM, Paraoan L, Hiscott P, Damato BE, Grierson I, Gray D, Farrell M, Doherty GA, Fitzgerald DJ, ; (2008) Current eye research Expression of COX-2 and prognostic outcome in uveal melanoma , pp.177-184 [DOI] [Details]
Cotter TG, O'Driscoll C, O'Connor J, O'Brien CJ, ; (2008) Journal of neurochemistry Basic fibroblast growth factor-induced protection from light damage in the mouse retina in vivo , pp.524-536 [DOI] [Details]
Sarfarazi M, Aragon-Martin JA, Ritch R, Liebmann J, O'Brien C, Blaaow K, Mercieca F, Spiteri A, Cobb CJ, Damji KF, Tarkkanen A, Rezaie T, Child AH, ; (2008) Molecular vision Evaluation of LOXL1 gene polymorphisms in exfoliation syndrome and exfoliation glaucoma , pp.533-541 [Details]
O'Brien, C. and Heneghan, C.; (2006) Variations in ECG derived respiratory signal frequency in REM and non-REM sleep SENSATION International Conference - Monitoring Sleep and Sleepiness Basel, Switzerland, , 29-MAY-06 - 30-MAY-06 [Details]
Healy, C.F., O'Brien, C., O'Herlihy, C. O'Connell, P.R.; (2006) The effects of obstetric trauma on the pudendal nerve - early report on the development of an acute animal model to simulate the anatomical distortions associated with childbirth Sylvestor O'Halloran Surgical Scientific Meeting [Details]
Keane, PA, O'Brien, C, McLoughlin, P, ; (2005) INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE The role of the nitric oxide precursor, L-arginine in angiogenesis involving the globally hypoxic adult retina [Details]
R. Shouldice, S. Ward, L.M. O'Brien, C. O'Brien, S. Redmond, D. Gozal, C. Heneghan; (2004) PR and PP ECG interval variation during obstructive apnea and hypopnea Proceedings of the IEEE 30th Annual Northeast Bioengineering Conference , pp.100-101 [Details]
O'Brien, CJ; Hanel, M; Dolan, V; Brady, HR; Hensey, C; ; (2003) INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE Expression and function of gremlin in the developing Xenopus eye , pp.127-127 [Details]
Quinn, S, O'Brien, C, McLoughlin, P, ; (2003) EYE Role of cyclooxygenase and haemoxygenase products in nitric oxide-independent vasodilatation in the porcine ciliary artery , pp.628-636 [DOI] [Details]
Quinn, S,O'Brien, C,McLoughlin, P (2003) EYE Role of cyclooxygenase and haemoxygenase products in nitric oxide-independent vasodilatation in the porcine ciliary artery , pp.628-636 [DOI] [Details]
Kirwan RP, Crean JK, Fenerty C, Clark AF, O'Brien.C (2003) Differential gene expression in normal primary human lamina cribrosa cells exposed to cyclical mechanical stretch: A model for glaucomatous optic neuropathy ARVO - The Association for Research in Vision and Ophthalmology [Details]
Devlin HC, Crean J, Fenerty C, Clark AF, O'Brien C. (2001) Effects of mechanical stretch on the expression of MMPs and TIMPs by trabecular meshwork cells ARVO [Details]
   

Editorial

O'Brien C, Clark AF (2015) Introduction to EER Special Issue on ocular fibrosis. Editorial [DOI] [Details]
                 

Abstract

Ratzlaff, MG,Murphy, A,O'Connor, K,O'Brien, C,Loughman, J,Connell, P (2012) MACULAR PIGMENT OPTICAL DENSITY MEASURED BY HETEROCHROMATIC FLICKER PHOTOMETRY IN DIABETIC AND NONDIABETIC PATIENTS: A COMPARATIVE STUDY. Abstract [Details]
O'Sullivan, H,Hughes, E,O'Brien, C,Wallace, D (2012) RETINAL PIGMENT EPITHELIAL CELL: POTENTIAL MEDIATOR OF OPTIC DISC CUPPING?. Abstract [Details]
Keane, PA,O'Brien, C,McLoughlin, P (2005) The role of the nitric oxide precursor, L-arginine in angiogenesis involving the globally hypoxic adult retina. Abstract [Details]
Cryan, LM,Pidgeon, GP,Fitzgerald, DJ,O' Brien, C (2004) COX-2 has a protective role in a mouse model of ischaemic retinopathy. Abstract [Details]
Chang, B,Madden, S,Doran, P,Kane, R,O'Brien, C (2003) In silico gene identification of eye specific genes. Abstract [Details]
Kane, R,Godson, C,Brady, HR,O'Brien, C (2003) Differential gene expression in human retinal pericytes in response to glucose and hypoxia. Abstract [Details]
Cryan, LM,Fitzgerald, DJ,O'Brien, C (2003) Isoform specific disruption of the cyclooxygenase genes in oxygen-induced retinopathy. Abstract [Details]
       

Reviews

Cryan, LM,O'Brien, C (2008) Proteomics as a research tool in clinical and experimental ophthalmology. Reviews [DOI] [Details]
Delaney, Y,Walshe, TE,O'Brien, C (2006) Vasospasm in glaucoma: Clinical and laboratory aspects. Reviews [Details]
   

Presentation

Ho S, Crean J, Oliver N, Klaus S, O'Brien C.; (2003) Elevated aqueous humour tissue inhibitor of matrix metalloproteinase-1 and connective tissue growth factor in pseudoexfoliation syndrome. Presentation [Details]
Kirwan RP, Crean JK, Fenerty C, Clark AF, O'Brien.C; (2003) Differential gene expression in normal primary human lamina cribrosa cells exposed to cyclical mechanical stretch: A model for glaucomatous optic neuropathy. Presentation [Details]
Devlin HC, Crean J, Fenerty C, Clark AF, O'Brien C.; (2001) Effects of mechanical stretch on the expression of MMPs and TIMPs by trabecular meshwork cells. Presentation [Details]
O'Brien CJ, Fenerty CH, Crean JKG, Clark AF; (2001) Production of matrix metalloprotease-2 by glauomatous and non-glaucomatous optic nerve astrocytes. Presentation [Details]
                                               

Research

Research Interests

Clinical: Glaucoma and Diabetic Retinopathy
Laboratory: Matrix and Vascular Biology, Neuro-degeneration
Health Services Research

Current Funding:
National Council for the Blind of Ireland 2005-2007, Mechanisms in diabetic retinopathy. €305,000; C O'Brien, N Sweeney, L Cryan


Health Research Board 2004-2006, North-South Grants, Molecular mechanism of retinal pericyte apoptosis in diabetic retinopathy €240,000 C O'Brien, A Stitt, T Cotter


National Glaucoma Research; American Health Assistance Foundation $90,000 2007-2009
Modulation of lamina cribrosa matrix remodeling in POAG


Glaucoma Research Foundation, New York $37,000 2007-2008
Elucidation of mechano-transduction pathways in lamina cribrosa cells: Implications for glaucomatous cupping.


Research Projects

Sponsor : Institute of Ophthalmology
Title : Intracellular Calcium Handling Defect in Glaucomatous Lamina Cribrosa Cells
Start Date / End Date : 01-OCT-08 / 30-SEP-09
Sponsor : Health Research Board (HRB)
Title : Novel Anti-Connective Tissue Growth Factor Antibody Therapy in Pseudoexfoliation Glaucoma
Start Date / End Date : 01-DEC-10 / 01-DEC-13
Sponsor : Health Research Board (HRB)
Title : Glaucoma: An Insight into Epigenomic Reprogramming
Start Date / End Date : 01-DEC-11 / 31-DEC-14
Sponsor : University College Dublin (UCD)
Title : School Funded Research Account
Start Date / End Date : 01-JAN-14 / 31-DEC-14
Sponsor : Health Research Board (HRB)
Title : The Effect of Oxidative Stress on the Epigenetic Profile of Human Trabecular Meshwork Cells
Start Date / End Date : 01-JUL-14 / 25-AUG-14
   

Collaborators

Internal Collaborators

External Collaborators

A Stitt (Belfast) T Cotter (Cork) B Harvey (Dublin)
A Clark (Fort Worth, Texas)