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Researchers at UCD

Donal Buggy

Professor of Anaesthesiology

School Of Medicine
Mater Hospital
Eccles Street
Dublin 7

Tel: 8032281
Email: donal.buggy@ucd.ie

Biography

I took up the part-time post of Professor of Anaesthesia in November 2012, having been appointed Professor to the Adjunct Clinical Faculty in 2008. Since 2001, I have worked as a Consultant in Anaesthesia in the Mater Misericordiae University Hospital.

Our unit remains at the forefront of worldwide research on perioperative influences on cancer recurrence and metastasis, particularly breast cancer.

I am Editorial Board Member of British Journal of Anaesthesia (BJA) since 2008, and in 2013 I edited a Special Issue on Anaesthesia and Cancer, online access, which has since had 20,000 downloads. This was a significant factor in propelling BJA to the No.1  ranked journal in the specialty this year (Impact Factor 5.6)

European Society Anaesthesiology Research Committee Member 2015-present, former member of Pharmacology Subcommittee (2010-2013).

Elected to Council of College of Anaesthetists of Ireland, Chairman Congress and CEPD Committee.

Funded by Air Liquide to continue investigating effects of xenon on cancer cell biology.

Funded by EU COST Action CA15204 "EURO-Periscope": European Platform for Investigation of Perioperative Interventions in Surgery for Cancer"

 
Funded by ESA 60K and College of Anaesthetists of Ireland (CAI) 69K, for animal studies in perioperative lidocaine in the 4T1 mouse model of breast cancer. 

Member of: Translational Oncology

Professional

 

Associations

Association: British Journal of Anaesthesia, Function/Role: Editorial Board Member
                       

Publications

Books

Fitzgerald, K. and Buggy, D. (2006) Nonconventional and Adjunctive Analgesia. : Elsevier Inc. [DOI] [Details]

Book Chapters

Buggy DJ, Ash S (2016) 'Outcomes after Anaesthesia' In: Hopkins P, Howell SJ (eds). Oxford Textbook of Anaesthesia. Oxford: Oxford University Press. [Details]
Abdulrahman D, Buggy DJ (2015) 'Anaesthesia and Cancer' In: Karen Stuart-Smith (eds). Perioperative Medicine. Sydney: Springer. [Details]
Shanahan H, Buggy DJ (2013) 'Experimental evidence for the effect of opioids in cancer' In: Parat MO (eds). Morphine and metastasis. Sydney: Springer. [Details]
Ash S, Buggy DJ (2013) 'Anaesthesia and analgesia and cancer metastasis' In: Riedel B (eds). Best practice & research clinical anaesthesiology. sydney: springer. [Details]
C Deegan, D Buggy (2011) 'Landmark papers in airway management' In: N. Webster, H. Galley (eds). Landmark Papers in Anaesthesia. Oxford: Oxford University Press. [Details]
 

Peer Reviewed Journals

Connolly C, Buggy DJ (2016) 'Opioids and tumour metastasis: does the choice of the anesthetic-analgesic technique influence outcome after cancer surgery?'. Current Opinion in Anaesthesiology, 29 (4):468-474. [DOI] [Details]
Meier, J; Filipescu, D; Kozek-Langenecker, S; Llau Pitarch, J; Mallett, S; Martus, P; Matot, I; ETPOS collaborators (2016) 'Intraoperative transfusion practices in Europe'. British Journal of Anaesthesia, 116 (2):255-261. [Details]
Myles, PS; Grocott, MP; Boney, O; Moonesinghe, SR; COMPAC-StEP Group (2016) 'Standardizing end points in perioperative trials: towards a core and extended outcome set'. British Journal of Anaesthesia, 116 (5):586-589. [Details]
O'Sullivan KE, Breen EP;Gallagher HC;Buggy DJ;Hurley JP (2016) 'Understanding STAT3 signaling in cardiac ischemia'. Basic Research in Cardiology, 111 (3). [DOI] [Details]
Kiernan, F. and Buggy, D. J. (2015) 'What's measured matters: measuring performance in anaesthesia'. BRITISH JOURNAL OF ANAESTHESIA, 114 (6):869-871. [DOI] [Details]
Whitlock, RP; Devereaux, PJ; Teoh, KH; Lamy, A; Vincent, J; Pogue, J; Paparella, D; Sessler, DI; Karthikeyan, G; Villar, JC; Zuo, Y; Avezum, Á; Quantz, M; Tagarakis, GI; Shah, PJ; Abbasi, SH; Zheng, H; Pettit, S; Chrolavicius, S; Yusuf, S; SIRS Investigators (2015) 'Methylprednisolone in patients undergoing cardiopulmonary bypass (SIRS): a randomised, double-blind, placebo-controlled trial'. Lancet, 386 (10000):1243-1253. [Details]
Gallagher HC, Gallagher RM;Butler M;Buggy DJ;Henman MC (2015) 'Venlafaxine for neuropathic pain in adults'. The Cochrane database of systematic reviews, (8). [DOI] [Details]
Levins KJ, Buggy DJ (2015) 'Perioperative interventions during cardiac surgery: can anaesthetic-analgesic technique influence outcome?'. Current Anesthesiology Reports, 5 (3):318-330. [Details]
L Marshall, Hameed Khan, DJ Buggy (2015) 'Can anaesthetic and analgesic techniques for cancer surgery affect recurrence and metastasis?'. Current Anesthesiology Reports, 5 :190-202. [Details]
Whitlock RP, SIRS Investigators (2015) 'Methylprednisolone in patients undergoing CPB with SIRS: A prospective, randomised trial'. Lancet, 386 (10000):1243-1253. [Details]
Desmond F, McCormack J;Mulligan N;Stokes M;Buggy DJ (2015) 'Effect of anaesthetic technique on immune cell infiltration in breast cancer: a follow-up pilot analysis of a prospective, randomised, investigator-masked study'. Anticancer Research, 35 (3):1311-1319. [Details]
A. Kurz, E. Fleischmann, D. I. Sessler, D. J. Buggy, C. Apfel and O. Akça (2015) 'Effects of supplemental oxygen and dexamethasone on surgical site infection: a factorial randomized trial'. British Journal of Anaesthesia, 115 (3):434-443. [DOI] [Details]
Byrne K, Levins KJ;Buggy DJ (2015) 'Can anesthetic-analgesic technique during primary cancer surgery affect recurrence or metastasis?'. Canadian Anaesthetists Society Journal, . [DOI] [Details]
Crowley, PD, Stuttgen V, O'Carroll E, Ash SA, Buggy DJ, Gallagher HC (2015) 'Oxygen stimulates migration and upregulates secretion of angiogenesis factors in oestrogen receptor (ER)-positive and ER-negative human breast cancer cell lines'. European Journal of Anaesthesiology, Supplement, 32 (s53):1AP17-1AP18. [Details]
Ecimovic P, Murray D, Doran P, Buggy DJ (2014) 'Propofol and bupivacaine in breast cancer cell function in vitro: role of the NET1 gene'. Anticancer Research, . [Details]
Buckley A, McQuaid S;Johnson P;Buggy DJ (2014) 'Effect of anaesthetic technique on the natural killer cell anti-tumour activity of serum from women undergoing breast cancer surgery: a pilot study'. British Journal of Anaesthesia, 113 Suppl 1 :1-62. [DOI] [Details]
Ash SA, Valchev GI, Crowley P, Gallagher H, Buggy DJ (2014) 'Xenon and breast cancer cell function in vitro'. European Journal of Anaesthesiology, 31 :160. [Details]
Gallagher H.C., Gallagher R.M., Butler M, Buggy D.J., Henman M.C. (2014) 'Venlafaxine for neuropathic pain (Protocol)'. Cochrane Database of Systematic Reviews, . Available Online [DOI] [Details]
Ash SA, Valchev GI, Looney M, Ni Mhathuna A, Crowley PD, Gallagher HC, Buggy DJ (2014) 'Xenon decreases cell migration and secretion of a pro-angiogenesis factor in breast adenocarcinoma cells: comparison with sevoflurane'. British journal of anaesthesia, 113 Suppl 1 :14-21. [DOI] [Details]
Jaura AI, Flood G, Gallagher HC, Buggy DJ (2014) 'Differential effects of serum from patients administered distinct anaesthetic techniques on apoptosis in breast cancer cells in vitro: a pilot study'. British journal of anaesthesia, 113 Suppl 1 :1-7. [DOI] [Details]
Ecimovic P, McHugh B, Murray D, Doran P, Buggy DJ (2013) 'Effects of sevoflurane on breast cancer cell function in vitro'. Anticancer Research, :4255-4260. [Details]
Ni Mhathuna A, Valchev G, Ash S, Buggy DJ, Gallagher HC (2013) 'The anaesthetic gases, xenon and sevoflurane, have opposing effects on breast cancer cell migration in vitro'. Irish Journal of Medical Science, 182 :S504-S505. [Details]
Jaura A, Buggy D, Gallagher H (2013) 'The influence of anaesthetic technique on apoptosis in ER negative breast cancer cells'. European Journal of Anaesthesiology, 30 :145-145. [Details]
Jaura AI, Flood G, Gallagher HC, Buggy DJ (2013) 'Serum from patients administered distinct anaesthetic techniques has differential effects on apoptosis in ER negative breast cancer cells in vitro'. British journal of anaesthesia, 111 (5):856-857. [Details]
Conrick-Martin I, Buggy DJ (2013) 'Effects of anesthetic and analgesic techniques on immune function'. Journal of Clinical Anesthesia, :253-254. [Details]
Niwa H, Lambert DJ< Rowbotham DJ, Buggy DJ (2013) 'Can anaesthetic techniques and drugs affect cancer recurrence in patients undergoing cancer surgery?'. Journal of anesthesia, . [Details]
Akca O, Kurz A, Fleischmann E, Buggy D, Sessler DI (2013) 'Hypercapnia and surgical site infaction: a randomised controlled trial'. British journal of anaesthesia, . [Details]
Conrick-Martin I, Kell MR, Buggy DJ. (2012) 'Meta-analysis of the effect of central neuraxial regional anesthesia compared with general anesthesia on postoperative natural killer T lymphocyte function'. Journal of Clinical Anesthesia, . [Details]
Colvin L, Fallon M, Buggy DJ (2012) 'Cancer biology, anaesthetics and analgesics: Is there a link?'. British journal of anaesthesia, :140-143. [Details]
Heaney, A,Buggy, DJ (2012) 'Can anaesthetic and analgesic techniques affect cancer recurrence or metastasis?'. British Journal of Anaesthesia, 109 :17-28. [DOI] [Details]
Doherty, M,Buggy, DJ (2012) 'Intraoperative fluids: how much is too much?'. British Journal of Anaesthesia, 109 :69-79. [DOI] [Details]
Ecimovic P, Murray D, Doran P, McDonald J, Lambert DG, Buggy DJ; (2011) 'Direct effect of morphine on breast cancer cell function in vitro: role of the NET1 gene'. British Journal of Anaesthesia, . [DOI] [Details]
Elsaigh I, Montgomery T, Moriarty DC, Buggy D, Gallagher HC (2011) 'Cell cycle protein expression as a marker of anaesthetic-induced developmental toxicity'. European Journal of Anaesthesiology, 28 :S48. [Details]
Thorton P., Buggy DJ., (2011) 'Postoperative local anaesthetic infusion analgesia'. British Journal of Aesthetics, 107 :656-658. [Details]
Ecimovic P., Doran P., Lambert DG., Buggy DJ., (2011) 'Role of NET1 Gene in effect of morphine on breast cancer cell function in vitro'. British journal of anaesthesia, . [Details]
Deegan CA, Murray D, Doran P, Moriarty DC, Sessler DI, Mascha E, Kavanagh BP, Buggy DJ; (2010) 'Anesthetic technique and the cytokine and matrix metalloproteinase response to primary breast cancer surgery'. Regional Anesthesia and Pain Medicine, 35 (6):490-495. [DOI] [Details]
Casey E, Lane A, Kuriakose D, McGeary S, Hayes N, Phelan D, Buggy D.; (2010) 'Bolus remifentanil for chest drain removal in ICU: a randomized double-blind comparison of three modes of analgesia in post-cardiac surgical patients'. Intensive Care Medicine, 36 (8):1380-1385. [Details]
Ng CT, Biniecka M, Kennedy A, McCormick J, Fitzgerald O, Bresnihan B, Buggy D, Taylor CT, O'Sullivan J, Fearon U, Veale DJ; (2010) 'Synovial tissue hypoxia and inflammation in vivo'. Annals of the Rheumatic Diseases, 69 (7):1389-1395. [DOI] [Details]
Looney M, Doran P, Buggy DJ. (2010) 'Effect of anesthetic technique on serum vascular endothelial growth factor C and transforming growth factor β in women undergoing anesthesia and surgery for breast cancer'. Anesthesiology, 113 (5):1118-1125. [Details]
Eissa D, Carton EG, Buggy DJ. (2010) 'Anaesthetic management of patients with severe sepsis'. British Journal of Aesthetics, . [Details]
Buggy DJ; (2009) 'Central neuraxial block: defining risk more clearly'. British Journal of Anaesthesia, 102 (2):151-153. [DOI] [Details]
Ecimovic, P.Ecimovic, P.,Murray, D.Murray, D.,Deegan, C.Deegan, C.,Doran, P.Doran, P.,Moriarty, D. C.Moriarty, D. C.,Buggy, D. J.Buggy, D. J.; (2009) 'Morphine Increases Breast Cancer Cell Proliferation and Migration in Vitro'. Intensive Care MedicineIntensive Care MedicineIntensive Care Medicine, 35 :60-6060. Available Online [Details]
Deegan CA, Murray D, Doran P, Ecimovic P, Moriarty DC, Buggy DJ.; (2009) 'Effect of anaesthetic technique on oestrogen receptor-negative breast cancer cell function in vitro'. British journal of anaesthesia, 103 (5):685-690. [Details]
Biki, B,Mascha, E,Moriarty, DC,Fitzpatrick, JM,Sessler, DI,Buggy, DJ; (2008) 'Anesthetic technique for radical prostatectomy surgery affects cancer recurrence - A retrospective analysis'. Anesthesiology, 109 :180-187. [Details]
Burlacu CL, Frizelle HP, Moriarty DC, Buggy DJ; (2007) 'Pharmacokinetics of levobupivacaine, fentanyl, and clonidine after administration in thoracic paravertebral analgesia'. Regional Anesthesia and pain medicine, 32 (2):136-145. [Details]
Walshe C, Phelan D, Bourke J, Buggy D. ; (2007) 'Vascular erosion by central venous catheters used for total parenteral nutrition'. Intensive Care Medicine, 33 (3):534-537. [Details]
Buggy DJ, Mascha E, Sessler D. ; (2007) 'Regional block and cancer recurrence: too early to tell'. Anesthesiology, 107 (2):354-355. [Details]
Burlacu CL, Frizelle HP, Moriarty DC, Buggy DJ. ; (2007) 'Pharmacokinetics of levobupivacaine, fentanyl, and clonidine after administration in thoracic paravertebral analgesia'. Regional Anesthesia and pain medicine, 32 (2):136-145. [Details]
Arain MR, Buggy DJ.; (2007) 'Anaesthesia for cancer patients'. Current Opinion in Anaesthesiology, 20 (3):247-253. [Details]
Exadaktylos AK, Buggy DJ, Moriarty DC, Mascha E, Sessler DI. ; (2006) 'Can anesthetic technique for primary breast cancer surgery affect recurrence or metastasis?'. Anesthesiology, 105 (4):660-664. [Details]
Burlacu CL, Frizelle HP;Moriarty DC;Buggy DJ (2006) 'Fentanyl and clonidine as adjunctive analgesics with levobupivacaine in paravertebral analgesia for breast surgery'. Anaesthesia, 61 (10):932-937. [DOI] [Details]
Rohan, D; Buggy, DJ; Crowley, S; Ling, FKH; Gallagher, H; Regan, C; Moriarty, DC; ; (2005) 'Increased incidence of postoperative cognitive dysfunction 24 hr after minor surgery in the elderly'. Canadian Journal of Anaesthesia, 52 (2):137-142. [Details]
Bates, JJ; Watson, RWG; Glynn, CM; O'Neill, AJ; Fitzpatrick, JM; Buggy, DJ; ; (2004) 'Aspirin preserves neutrophil apoptosis after cardiopulmonary bypass'. Shock, 21 (6):495-499. [Details]
Buggy, DJ,Kerin, MJ; (2004) 'Paravertebral analgesia with levobupivacaine increases postoperative flap tissue oxygen tension after immediate latissimus dorsi breast reconstruction compared with intravenous opioid analgesia'. Anesthesiology, 100 :375-380. [Details]
Bone, M,Critchley, P,Buggy, DJ; (2002) 'Gabapentin in postamputation phantom limb pain: A randomized, double-blind, placebo-controlled, cross-over study'. Pain, 27 :481-486. [DOI] [Details]
Buggy, DJ and Ahmed, N and Hart, E (2001) 'Instrumental delivery and epidural anaesthesia'. LANCET, 358 (9294):1726. [DOI] [Details]
Anderson, SL and Habib, AS and Sharpe, P and Shah, J and Buggy, D (2001) 'Iontophoretically applied lidocaine to produce analgesia prior to Tuohy needle insertion'. BRITISH JOURNAL OF ANAESTHESIA, 86 (2):322P. [Details]
Nortcliffe, SA and Phillips, G and Dulloo, A and Sharpe, P and Buggy, DJ (2001) 'Nimodipine and acute postoperative pain'. BRITISH JOURNAL OF ANAESTHESIA, 86 (2):303P. [Details]
Ayorinde, BT and Buczkowski, P and Brown, J and Shah, J and Buggy, DJ (2001) 'Evaluation of pre-emptive intramuscular phenylephrine and ephedrine for reduction of spinal anaesthesia-induced hypotension during Caesarean section'. BRITISH JOURNAL OF ANAESTHESIA, 86 (3):372-376. [DOI] [Details]
Kirkbride, DA and Parker, JL and Williams, GD and Buggy, DJ (2001) 'Induction of anaesthesia in the elderly day-case patient: double-blind comparison of propofol and sevoflurane'. BRITISH JOURNAL OF ANAESTHESIA, 87 (1):166P. [Details]
Ayorinde, BT and Buggy, DJ (2001) 'Use of pre-emptive vasopressors for spinal anaesthesia-induced hypotension during Caesarean section'. BRITISH JOURNAL OF ANAESTHESIA, 87 (2):321. [Details]
Nortcliffe, SA and Buggy, DJ (2001) 'Prophylaxis of nausea and vomiting after spinal morphine analgesia for Caesarean section: comparison between cyclizine, dexamethasone, and placebo'. BRITISH JOURNAL OF ANAESTHESIA, 87 (4):657P. [Details]
Kirkbride, DA and Parker, JL and Williams, GD and Buggy, DJ (2001) 'Induction of anesthesia in the elderly ambulatory patient: A double-blinded comparison of propofol and sevoflurane'. ANESTHESIA AND ANALGESIA, 93 (5):1185-1187. [DOI] [Details]
Buggy, DJ and Asher, MJ and Lambert, DG (2000) 'Nimodipine premedication and induction dose of propofol'. ANESTHESIA AND ANALGESIA, 90 (2):445-449. [DOI] [Details]
Shah, J and Ayorinde, BT and Rowbotham, DJ and Buggy, DJ (2000) 'Warm air sensation for assessment of block after spinal anaesthesia'. BRITISH JOURNAL OF ANAESTHESIA, 84 (3):399-400. [Details]
Buggy, DJ and Nicol, B and Rowbotham, DJ and Lambert, DG (2000) 'Effects of intravenous anesthetic agents on glutamate release - A role for GABA(A) receptor-mediated inhibition'. ANESTHESIOLOGY, 92 (4):1067-1073. [DOI] [Details]
Buggy, DJ and Crossley, AWA (2000) 'Thermoregulation, mild perioperative hypothermia and postanaesthetic shivering'. BRITISH JOURNAL OF ANAESTHESIA, 84 (5):615-628. [Details]
Powell, RM and Buggy, DJ (2000) 'Ondansetron given before induction of anesthesia reduces shivering after general anesthesia'. ANESTHESIA AND ANALGESIA, 90 (6):1423-1427. [DOI] [Details]
Buggy, D (2000) 'Can anaesthetic management influence surgical-wound healing?'. LANCET, 356 (9227):355-357. [DOI] [Details]
Ayorinde, BT and Scudamore, I and Buggy, DJ (2000) 'Anaesthetic management of a pregnant patient in a persistent vegetative state'. BRITISH JOURNAL OF ANAESTHESIA, 85 (3):479-481. [Details]
Buggy, DJ and Hall, NA and Shah, J and Brown, J and Williams, J (2000) 'Motor block during patient-controlled epidural analgesia with ropivacaine or ropivacaine/fentanyl after intrathecal bupivacaine for Caesarean section'. BRITISH JOURNAL OF ANAESTHESIA, 85 (3):468-470. [Details]
Caranza, R and Teyapalan, I and Buggy, DJ (1999) 'Central neuraxial opioid analgesia after caesarean section: comparison of epidural diamorphine and intrathecal morphine'. INTERNATIONAL JOURNAL OF OBSTETRIC ANESTHESIA, 8 (2):90-93. [DOI] [Details]
Cagney B, Williams O, Jennings L, Buggy D (1999) 'Tramadol or fentanyl analgesia for ambulatory knee arthroscopy'. European Journal of Anaesthesiology, 16 (3):182-185. [Details]
Molloy, ME and Buggy, DJ and Scanlon, P (1999) 'Propofol or sevoflurane for laryngeal mask airway insertion'. CANADIAN JOURNAL OF ANAESTHESIA-JOURNAL CANADIEN D ANESTHESIE, 46 (4):322-326. [Details]
Buggy, D (1999) 'Ambulation during regional analgesia for labour should be discouraged'. INTERNATIONAL JOURNAL OF OBSTETRIC ANESTHESIA, 8 (3):179-180. [DOI] [Details]
Buggy, DJ and Lambert, DG (1999) 'Reversal of the inhibitory effect of propofol, but not of ketamine, on K+ evoked glutamate release from rat cerebrocortical slices by the GABA(A) antagonist bicuculline'. BRITISH JOURNAL OF ANAESTHESIA, 83 (1):174P. [Details]
Buggy, DJ and Smith, G (1999) 'Epidural anaesthesia and analgesia: better outcome after major surgery? Growing evidence suggests so'. BRITISH MEDICAL JOURNAL, 319 (7209):530-531. [Details]
Buggy, DJ and Allsager, CM and Coley, S (1999) 'Profound motor blockade with epidural ropivacaine following spinal bupivacaine'. ANAESTHESIA, 54 (9):895-898. [Details]
Buggy, DJ and Asher, MJ and Lambert, DG (1999) 'Nimodipine premedication and induction dose of propofol'. BRITISH JOURNAL OF ANAESTHESIA, 82 (3):448P. [Details]
Anderson, S and Buggy, D (1999) 'Prolonged pharyngeal obstruction after the Heimlich manoeuvre'. ANAESTHESIA, 54 (3):308-309. [Details]
Buggy, DJ and Power, CK and Meeke, R and O'Callaghan, S and Moran, C and O'Brien, GT (1998) 'Prevention of spinal anaesthesia-induced hypotension in the elderly: im methoxamine or combined hetastarch and crystalloid'. BRITISH JOURNAL OF ANAESTHESIA, 80 (2):199-203. [Details]
Buggy, D and Fitzpatrick, G (1998) 'Intravascular volume optimisation during repair of proximal femoral fracture - Regional anaesthesia is usually technique of choice'. BRITISH MEDICAL JOURNAL, 316 (7137):1090. [Details]
Buggy, DJ and Nicol, B and Lambert, DG (1998) 'Reversal of thiopentone-induced inhibition of K+-envoked glutamate release from rat cerebrocortical slices by the GABA(A) antagonist, bicuculline'. ANESTHESIOLOGY, 89 (3A, S):U214. [Details]
Buggy, D (1998) 'Dorsal column function after spinal/epidural anaesthesia'. ANAESTHESIA, 53 (9):925-926. [DOI] [Details]
Buggy, DJ and Hughes, N (1998) 'Acute airway obstruction during spinal anaesthesia for caesarean section'. INTERNATIONAL JOURNAL OF OBSTETRIC ANESTHESIA, 7 (4):267-270. [DOI] [Details]
Ambrose, C and Buggy, D and Farragher, R and Troy, A and McNulty, C and Carey, M (1998) 'Pre-emptive glycopyrrolate 0.2 mg and bradycardia during gynaecological laparoscopy with mivacurium'. EUROPEAN JOURNAL OF ANAESTHESIOLOGY, 15 (6):710-713. [Details]
Buggy, D (1998) 'Intra-operative bradycardia in gynaecological surgery'. ANAESTHESIA, 53 (8):824. [DOI] [Details]
Buggy, D (1998) 'Peripheral blocks of the lower limb for repair of fractured neck of femur'. BRITISH JOURNAL OF ANAESTHESIA, 81 (3):484. [Details]
Power, CK and Buggy, D and Keogh, J (1997) 'Acute superior vena caval syndrome with airway obstruction following elective mediastinoscopy'. ANAESTHESIA, 52 (10):989-992. [DOI] [Details]
Buggy, D and Higgins, P and Moran, C and OBrien, D and ODonovan, F and McCarroll, M (1997) 'Prevention of spinal anesthesia-induced hypotension in the elderly: Comparison between preanesthetic administration of crystalloids, colloids, and no prehydration'. ANESTHESIA AND ANALGESIA, 84 (1):106-110. [DOI] [Details]
Buggy, D (1997) 'Intrathecal morphine dose for caesarean section'. ANAESTHESIA, 52 (3):278. [Details]
Buggy, D and Higgins, P and Moran, C and ODonovan, F and McCarroll, M (1997) 'Clonidine at induction reduces shivering after general anaesthesia'. CANADIAN JOURNAL OF ANAESTHESIA-JOURNAL CANADIEN D ANESTHESIE, 44 (3):263-267. [Details]
Buggy, DJ and MacDowell, C (1996) 'Extradural analgesia with clonidine and fentanyl compared with 0.25\% bupivacaine in the first stage of labour'. BRITISH JOURNAL OF ANAESTHESIA, 76 (2):319-321. [Details]
Buggy, DJ (1996) 'Recent advances in obstetrics - Epidural analgesia in labour'. BRITISH MEDICAL JOURNAL, 312 (7027):379. [Details]
Buggy, D (1996) 'Shivering during epidural anesthesia - Reply'. ACTA ANAESTHESIOLOGICA SCANDINAVICA, 40 (3):394. [Details]
MacEvilly, M and Buggy, D (1996) 'Back pain and pregnancy: A review'. PAIN, 64 (3):405-414. [DOI] [Details]
Buggy, DJ and OBrien, D and Higgins, P and Moran, C and ODonovan, F and McCarroll, M (1996) 'Prevention of spinal anaesthesia induced hypotension in the elderly: Comparison between crystalloid, colloid and NO preload solution'. BRITISH JOURNAL OF ANAESTHESIA, 76 (2):A239. [Details]
Buggy, D and Higgins, P and OBrien, D and Moran, C and ODonovan, F and McCarroll, M (1996) 'Clonidine at induction reduces shivering after general anaesthesia'. BRITISH JOURNAL OF ANAESTHESIA, 76 (2):A293. [Details]
Buggy, D and MacDowell, C (1996) 'Extradural analgesia in the first stage of labour'. BRITISH JOURNAL OF ANAESTHESIA, 76 (6):887. [Details]
Buggy, D and MacEvilly, M (1996) 'Do epidurals cause back pain?'. BRITISH JOURNAL OF HOSPITAL MEDICINE, 56 (2-3):99-101. [Details]
Buggy, D and Murphy, K and VanHaaster, J and Feely, J (1996) 'Resistance followed by prolonged neuromuscular block with vecuronium'. ACTA ANAESTHESIOLOGICA SCANDINAVICA, 40 (7):862-863. [Details]
Buggy, DJ and OBrien, D and Higgins, P and Moran, C and ODonovan, F (1996) 'Crystalloid, colloid or no preload for prevention of spinal anaesthesia induced hypotension in the elderly'. ANESTHESIOLOGY, 85 (3A, S):A110. [Details]
Buggy, D and Higgins, P and OBrien, D and Moran, C and ODonovan, F and McCarroll, M (1996) 'Clonidine at induction reduces shivering after general anaesthesia'. ANESTHESIOLOGY, 85 (3A, S):A42. [Details]
Carroll, M and Day, F and Hennessy, A and Buggy, D and Cooney, C (1996) 'Patient attitudes to perioperative suppository administration for postoperative analgesia'. IRISH JOURNAL OF MEDICAL SCIENCE, 165 (4):286-288. [DOI] [Details]
Buggy, D and Keaveny, J and Browne, L (1996) 'Percutaneous radiofrequency thermocoagulation of the Gasserian ganglion for severe trigeminal neuralgia'. PAIN CLINIC, 9 (3):269-274. [Details]
BUGGY, D and HUGHES, N and GARDINER, J (1995) 'AMBULATORY EXTRADURAL ANALGESIA'. BRITISH JOURNAL OF ANAESTHESIA, 75 (2):248. [Details]
BUGGY, D and HUGHES, H and GARDINER, J (1995) 'POSTERIOR COLUMN SENSORY IMPAIRMENT DURING AMBULATORY EXTRADURAL ANALGESIA IN LABOR - REPLY'. BRITISH JOURNAL OF ANAESTHESIA, 74 (3):350. [DOI] [Details]
BUGGY, D (1995) 'BUPIVACAINE-FREE ANALGESIA FOR THE FIRST STAGE OF LABOR WITH CLONIDINE-FENTANYL'. BRITISH JOURNAL OF ANAESTHESIA, 74 (4):P481. [Details]
BUGGY, D and GARDINER, J (1995) 'THE SPACE BLANKET AND SHIVERING DURING EXTRADURAL ANALGESIA IN LABOR'. ACTA ANAESTHESIOLOGICA SCANDINAVICA, 39 (4):551-553. [Details]
BUGGY, D and SCHNITTGER, T and FOX, L (1995) 'LACK OF AIRWAY CONTROL IN GENERAL-ANESTHESIA'. BRITISH JOURNAL OF HOSPITAL MEDICINE, 53 (9):474. [Details]
BUGGY, D and HUGHES, N and GARDINER, J (1995) 'AMBULATORY EXTRADURAL ANALGESIA - REPLY'. BRITISH JOURNAL OF ANAESTHESIA, 75 (1):114-115. [Details]
BUGGY, D and HUGHES, N (1994) 'PREEMPTIVE USE OF THE SPACE BLANKET REDUCES SHIVERING AFTER GENERAL-ANESTHESIA'. BRITISH JOURNAL OF ANAESTHESIA, 72 (4):393-396. [DOI] [Details]
ADEBAYO, GI and GAFFNEY, P and BUGGY, D and FEELY, J (1994) 'ACUTE INHIBITORY EFFECT OF ALCOHOL ON SODIUM-LITHIUM COUNTERTRANSPORT'. ALCOHOL, 11 (5):367-370. [DOI] [Details]
BUGGY, D and HUGHES, N and GARDINER, J (1994) 'POSTERIOR COLUMN SENSORY IMPAIRMENT DURING AMBULATORY EXTRADURAL ANALGESIA IN LABOR'. BRITISH JOURNAL OF ANAESTHESIA, 73 (4):540-542. [DOI] [Details]
BUGGY, DJ and WALL, C and CARTON, EG (1994) 'PREOPERATIVE OR POSTOPERATIVE DICLOFENAC FOR LAPAROSCOPIC TUBAL-LIGATION'. BRITISH JOURNAL OF ANAESTHESIA, 73 (6):767-770. [DOI] [Details]
BUGGY, D and SCHNITTGER, T and FOX, L (1994) 'AIRWAY MANAGEMENT AFTER SEVERE FACIAL CONTRACTURES'. BRITISH JOURNAL OF HOSPITAL MEDICINE, 52 (7):367. [Details]
BUGGY, D and BREATHNACH, A and KEOGH, B and COOKE, T and FEELY, J (1993) 'LIPOPROTEIN(A) AND TREATMENT OF CHRONIC RENAL-DISEASE'. JOURNAL OF INTERNAL MEDICINE, 234 (5):453-455. [Details]
BUGGY, D and FEELY, J and MURPHY, J and OSULLIVAN, C and WALSH, M (1993) 'MICROALBUMINURIA AND CORONARY HEART-DISEASE IN NON-DIABETICS'. POSTGRADUATE MEDICAL JOURNAL, 69 (815):704-707. [Details]
 

Conference Publications

Ash SA, Valchev GI, Looney M, Ni Mhathuna A, Crowley PD, Gallagher HC, Buggy DJ (2014) Xenon and sevoflurane effects on migration and expression of angiogenesis factors in breast adenocarcinoma cells in vitro The College of Anaesthetists of Ireland: Delaney Medal Competition 2014 College of Anaesthetists of Ireland, Dublin, Ireland [Details]
Jaura AI, Flood G, Gallagher HC, Buggy DJ (2013) Serum from patients administered distinct anaesthetic techniques has differential effects on apoptosis in ER negative breast cancer cells in vitro Delaney Medal Competition, The College of Anaesthetists of Ireland [Details]
El-Saigh I, Buggy DJ, Gallagher H. (2011) A novel in vitro method for predicting anesthetic-induced developmental toxicity American Society Anesthsiologists Congress Oct 2011, Chicago: Anesthesiology 2011 Chicago, , pp.A699 [Details]
El-Saigh I, Buggy DJ, Gallagher H. (2011) Cyclin D3 and predicting anaesthetic toxicity European Society Anaesthesiologists Congress, Amsterdam June 2011, European Journal Anaesthesiologists, 2011 Amsterdam, [Details]
Ecimovic P, Doran P, Buggy DJ. (2010) Effect of sevofliurane on breast cancer cell function in vitro European Society Anaesthesiologists Congress, Helsinki 2010, European Journal Anaesthesiologists, 2010 Helsinki, [Details]
O'Farrell, R.; Buggy, D.; Foley, A.; Gallagher, H.; Moriarty, D.; Regan, C ; (2006) Susceptibility of the developing brain to neuronal damage induced by clinical anaesthetic agents European Society of Anesthesiology [Details]
   

Editorial

Connolly C, Miskolci O;Phelan D;Buggy DJ (2016) End-of-life in the ICU: moving from 'withdrawal of care' to a palliative care, patient-centred approach. Editorial [DOI] [Details]
                                                                                   

Research

Research Interests

*Evaluating effect of anaesthesia and analgesic drugs and techniques on cancer cell biology and clinical cancer outcome;
*Long term clinical outcomes after anaesthesia
*Acute pain including role of regional anaesthesia;
*Biomarkers of toxicity in anaesthetic drugs;
*Thermoregulation during anaesthesia

Research Projects

Sponsor : European Society of Anaesthesiology (ESA)
Title : Does perioperative IV lidocaine infusion during tumour resection surgery reduce metastatic disease in the 4T1 mouse model of breast cancer?
Start Date / End Date : 10-DEC-15 / 31-DEC-18
Sponsor : Mater Private Hospital
Title : Examining the therapeutic potential of JAK/STAT signaling manipulation in cardiac myocytes.
Start Date / End Date : 01-MAR-15 / 31-MAR-18
Sponsor : L'Air Liquide
Title : Influence of xenon gas on breast cancer metastasis, recurrence and survival in vivo.
Start Date / End Date : 19-SEP-14 / 18-MAR-16
Sponsor : University College Dublin (UCD)
Title : School funded research account
Start Date / End Date : 01-OCT-14 / 31-DEC-19
Sponsor : L'Air Liquide
Title : Influence of xenon gas on breast cancer cell viability and metastasis.
Start Date / End Date : 12-DEC-11 / 31-DEC-16
Sponsor : University College Dublin Foundation Ltd.
Title : Georgina Flood's Consumables Account
Start Date / End Date : 01-AUG-10 / 31-DEC-17

Recent Postgraduates

*Rachel O'Farrell MD (2009)
*Catherine Deegan MD (2010)
*Ismat El-Saigh MD (2012)
 

Collaborators

Internal Collaborators

1. Dr John Hurley, Cardiothoracic Surgeon, Mater Private Hospital, Dr. Lauren McDonagh, Conway Institute: "Investigation of the JAK-STAT3 signalling mechanism in hypoxic myocardial protection".

2. Dr Helen Gallagher, Senior Lecturer, School of Medicine: Experimental studies on the effect of xenon and O2 in cancer cell biology." 

3. Dr. Andrew Foley, Brerand Ltd. "Perioperative Lidocaine and the 4T1 model of breast cancer".

External Collaborators

1. Dr  Dan Sessler, Outcomes Research, Cleveland Clinic, USA. RCT on anaesthetic technique in breast cancer and its effects on recurrence or metastasis.

2. Australian & New Zealand College of Anaesthetists, lead by Paul Myles (Melbourne) and Tim Short (Auckland NZ) on "Balanced" trial of anaesthetic depth and clinical postoperative outcomes;

3. European Society Anaesthesiology (ESA) Clinical Trials Network: Contributed to EuSOS, EtPOS, POPULAR.

4. DCU: Noel McCaffrey, "Influence of short, community based exercise prohramme on postoperative morbidity scores after scancer surgery"

5. DCU: Patricia Johnson: "Effects of anaesthetic technique during breast cancer surgery on Natural Killer cell function".

6. St Vincent's and Tallaght Hospitals, and UK Hip Fracture Database: "HipHOP: Evaluation of tight intraoperative blood pressure control during surgical repair of hip fracture"