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Researchers at UCD

Donal O'Shea

Associate Clinical Professor

School Of Medicine
St Vincent's Hospital
Elm Park
Dublin 4

Tel:
Email: info@dosheaendo.ie

Biography

The Obesity Immunology group¿s research is focused immune system dysregulation in obese adults and children and the effect of gut hormones and diabetes medication on innate cell function. We are primarily interested in cells of the innate immune system; invariant natural killer T cells (iNKT cells), MAIT cells, Vδ3 T cells and Dendritic cells. These cells have been found to be impacted by the obese condition. I am also affiliated with UCD Conway Institute of Biomolecular and Biomedical Research, where I have forged close ties with Prof Carel Le Roux and am in active collaboration with Prof Helen Roche and Dr Fiona McGillicuddy.

Professional

Honours and Awards

Year: 2011.
Title: Philanthropic donation
Year: 2011.
Title: National Children's Research Centre Obesity Consortium Project Grant
Year: 2011.
Title: Newman Scholarship Programme Funding
Year: 2009.
Title: Irish Heart Foundation Research Awards
Year: 2010.
Title: Health Research Board Clinical Research Training Fellowship
Year: 2009.
Title: Irish Heart Foundation Project Grant
Year: 2007.
Title: Health Research Board Clinical Research Training Fellowship
Year: 2006.
Title: Diabetes Federation of Ireland Health Research Board Project Grant
Year: 2008.
Title: Newman Scholarship Funding
Year: 2011.
Title: Newman Scholarships Funding
Year: 2008.
Title: Newman Scholarships Funding
Year: 2006.
Title: Newman Scholarship
Year: 2005.
Title: Health Research Board Clinical Research Training Fellowship
Year: 1999.
Title: Wellcome Trust Project Grant
Year: 1998.
Title: 50 Years of the NHS Anniversary Award, Charing Cross League of Friends
Year: 1997.
Title: British Diabetic Association Project Grant 1997
Year: 1997.
Title: Royal Postgraduate Medical School PhD studentships
Year: 1995.
Title: Royal Postgraduate Medical School PhD studentships
Year: 2008.
Title: UCD Premier Award for Undergraduate Teaching Excellence
Year: 2007.
Title: UCD Premier Award for Undergraduate Teaching Excellence
Year: 2006.
Title: UCD Premier Award for Undergraduate Teaching Excellence
Year: 2005.
Title: UCD Premier Award for Undergraduate Teaching Excellence
Year: 2004.
Title: UCD Premier Award for Undergraduate Teaching Excellence
Year: 2003.
Title: UCD Premier Award for Undergraduate reaching Excellence
Year: 2006.
Title: Irish Endocrine Society O' Donovan Medal awarded for group's research activity
Year: 1999.
Title: Imperial College School of Medicine Undergraduate Teacher of the year
Year: 1998.
Title: Norman Plummer Prize for Postgraduate Clinical Research
Year: 1996.
Title: Patrick M Meenan UCDMGA Inaugaral Research Medal
Year: 1993.
Title: Wellcome Trust Research Training Fellowship
Year: 1989.
Title: UCD and Mater Hospital Leonard Prize in Medicine
Year: 1988.
Title: University College Dublin Medical Society President's Prize
Year: 1987.
Title: Auditor University College Dublin Medical Society

Associations

Association: Royal College of Physicians of Ireland, Function/Role: Fellow
Association: American Society of Andrology, Function/Role: Member
Association: The (American) Endocrine Society, Function/Role: Member
Association: Amercian Medical Association, Function/Role: Member
Association: Irish Endocrine Society, Function/Role: Member
Association: Royal Academy of Medicine Ireland, Function/Role: Member
Association: HSE implementation group for the recommendations of the Obesity Taskforce , Function/Role: Obesity care and management
Association: National Obesity Taskforce , Function/Role: Author of detection and treatment of obesity report
Association: Irish Endocrine Society, Function/Role: Secretary (2004-2008)
Association: Special Action Group on Obesity , Function/Role: Member
Association: The Endocrine Society and The International Association for the Study of Obesity, Function/Role: Member
     

Conference Contributions

Quinn, A., Doody, C., Fogarty, E., O'Shea, D.; (2006) The effect of an 18 week group exercise education program on weight, physical activity, cardiovascular fitness, quality of life and attitudes to exercise in obese Irish female adults. [Invited Oral Presentation], European Congress of Endocrinology incorporating the British Endocrine Societies, Glasgow, Scotland , 01-APR-06 - 05-APR-06.
Ahern T, Tobin AM, Corrigan M, Hogan A, Kirby B, O'Shea D; (2011) Liraglutide Decreases Psoriasis Severity. [Poster Presentation], European Association for the Study of Diabetes Annual Meeting in 2011, Lisbon , 12-SEP-11 - 16-SEP-11.
Ahern T, Corrigan M, O¿Malley E, Dunlevy C, O'Shea D, Hayes FJ; (2011) Obese Men with Both Elevated Oestradiol and Low Testosterone Levels have an Adverse Cardiovascular Risk Profile. [Poster Presentation], The (American) Endocrine Society Annual Meeting in 2011, Boston , 06-APR-11 - 07-JUN-11.
Lydia Lynch, Donal O'Shea, Michael Nowak, Bindu Varghese, Andrew Hogan, Steven P. Balk, Cliona O'Farrelly, Mark A. Exley.; (2011) A role for innate immune cells in Diet-Induced Obesity and Insulin Resistance Through Regulatory Cytokine Production. [Oral Presentation], The Annual Meeting for the Irish Endocrine Society 2011, Antrim , 11-NOV-11 - 12-NOV-11.
Ahern T, Corrigan M, Gaoatswe G, Sweeney C, Hogan A, O'Shea D, Hayes FJ; (2011) Normalising the Sex Hormone Balance Modulates Pro-inflammatory Cytokine Secretion in Obese Men. [Oral Presentation], The Annual Meeting for the Irish Endocrine Society 2011, Antrim , 11-NOV-11 - 12-NOV-11.
Gaoatswe G, Ahern T, Corrigan M, Hogan A, O¿Shea D ; (2011) P38 people with type 2 Diabetes have low numbers of Invariant Natural Killer T cells. [Poster Presentation], 35th Annual Irish Endocrine Society Meeting, London , 05-NOV-11 - 06-NOV-11.
Gaoatswe G, Mc Gowan L, El Faki Y, Tamagno G, Cantwell C, O'Shea D ; (2011) P39 Trans-Arterial hepatic Chemo--Embolisation for Metastaticneuroendocrine Tumours: Experience of an Irish Tertiary Referral Centre. [Poster Presentation], 35th Annual Irish Endocrine Society Meeting, London , 05-NOV-11 - 11-JUN-11.

Committees

Committee : Council of The Endocrine Society 2005-2007
Committee : Clinical scientist Task Force of Endocrine Society 2006
Committee : Endocrine society Annual Meeting Steering Committee - Clinical Chair 2004-2005
Committee : Endocrine Society Annual Meeting - Abstract Reviewer 2001

Employment

Employer: Mater Hospital
Position: Intern Mater Misericordiae Hospital
Employer: Wexford General Hospital,Mater Hospital, SVUH
Position: UCD 2 Year Medical SHO Rotation
Employer: Hammersmith Hospital
Position: Diabetes & Endocrinology Registrar (locum)
Employer: Hammersmith Hospital
Position: Diabetes & Endocrinology Registrar
Employer: Hammersmith Hospital
Position: Cardiology Registrar
Employer: Hammersmith Hospital
Position: Senior Registrar & Wellcome Trust Training Fellow, Department of Diabetes & Endocrinology
Employer: Charing Cross Hospital, Hammersmith Hospitals, NHS
Position: Consultant Physician / Senior Lecturer, Head of Department, Department of Diabetes & Endocrinology
Employer: St Vincent's University and St Columcille's Hospitals, Dublin and University College Dublin
Position: Consultant Physician & Endocrinologist & Associate Professor of Medicine

Education

Year 2002 Institution: London
Qualification: FRCP Subject: Endocriology
Year 1999 Institution: Royal College of Physicians
Qualification: FRCPI Subject: Endocrinology
Year 1992 Institution: Royal College of Ireland
Qualification: MRCPI Subject: Membership of the Royal College of Ireland
Year 1996 Institution: UCD
Qualification: MD Subject: The hypothalamic control of appetite and peripheral metabolism
Year 1989 Institution: NUI
Qualification: MB, BCh, BAO Subject: Medicine
         

Publications

     

Peer Reviewed Journals

Watson C, James S;O'Connell E;Gallagher J;O'Reilly J;Tallon E;Baugh J;O'Connell J;O'Shea D;Ledwidge M;McDonald K (2016) 'Influence of diabetes on natriuretic peptide thresholds in screening for Stage B heart failure'. Biomarkers, :1-6. [DOI] [Details]
O'Malley E, Ahern T;Dunlevy C;Lehane C;Kirby B;O'Shea D (2015) 'Obesity-related chronic lymphoedema-like swelling and physical function'. Qjm-An International Journal Of Medicine, 108 (3):183-187. [DOI] [Details]
Hams E, Bermingham R;Wurlod FA;Hogan AE;O'Shea D;Preston RJ;Rodewald HR;McKenzie AN;Fallon PG (2015) 'The helminth T2 RNase ¿¿1 promotes metabolic homeostasis in an IL-33 and group 2 innate lymphoid cell-dependent mechanism'. FASEB Journal, . [DOI] [Details]
Kiely C, Rocha J;O'Connor E;O'Shea D;Green S;Ega¿¿a M (2015) 'Influence of menopause and Type 2 diabetes on pulmonary oxygen uptake kinetics and peak exercise performance during cycling'. American Journal of Physiology - Regulatory Integrative and Comparative Physiology, 309 (8):1-83. [DOI] [Details]
Martin-Grace J, O'Tuathail M;Hannon MJ;Swan N;O'Shea D;Tamagno G (2015) 'Amlodipine for the Medical Treatment of Adult-Onset Diffuse Nesidioblastosis'. Pancreas, 44 (7):1162-1164. [DOI] [Details]
Breen C, Ryan M;Gibney MJ;O'Shea D (2015) 'Diabetes-related nutrition knowledge and dietary intake among adults with type 2 diabetes'. British Journal of Nutrition, 114 (3):439-447. [DOI] [Details]
Mitchell PD, King TJ;O'Shea DB (2015) 'Subcutaneous Emphysema in Acute Asthma: A Cause for Concern?'. Respiratory Care, 60 (8):1-3. [DOI] [Details]
Mohan H, Nicholson P;Winter DC;O'Shea D;O'Toole D;Geoghegan J;Maguire D;Hoti E;Traynor O;Cantwell CP (2015) 'Radiofrequency ablation for neuroendocrine liver metastases: a systematic review'. Journal of Vascular and Interventional Radiology, 26 (7):935-9420. [DOI] [Details]
Carolan E, Tobin LM;Mangan BA;Corrigan M;Gaoatswe G;Byrne G;Geoghegan J;Cody D;O'Connell J;Winter DC;Doherty DG;Lynch L;O'Shea D;Hogan AE (2015) 'Altered distribution and increased IL-17 production by mucosal-associated invariant T cells in adult and childhood obesity'. Journal of Immunology, 194 (12):5775-5780. [DOI] [Details]
O'Connor E, Green S;Kiely C;O'Shea D;Ega¿¿a M (2015) 'Differential effects of age and type 2 diabetes on dynamic vs. peak response of pulmonary oxygen uptake during exercise'. Journal of Applied Physiology, 118 (8):1031-1039. [DOI] [Details]
Woods CP, Corrigan M;Gathercole L;Taylor A;Hughes B;Gaoatswe G;Manolopoulos K;Hogan AE;O'Connell J;Stewart PM;Tomlinson JW;O'Shea D;Sherlock M (2015) 'Tissue specific regulation of glucocorticoids in severe obesity and the response to significant weight loss following bariatric surgery (BARICORT)'. Journal of Clinical Endocrinology and Metabolism, 100 (4):1434-1444. [DOI] [Details]
Somerville R, McKenzie K;Eslami S;Breen C;O'Shea D;Wall P (2015) 'Poor mental health in severely obese patients is not explained by the presence of comorbidities'. Clinical Obesity, 5 (1):12-21. [DOI] [Details]
Breen, C. and Mckenzie, K. and Yoder, R. and Ryan, M. and Gibney, M.J. and O'Shea, D. (2015) 'A qualitative investigation of patients' understanding of carbohydrate in the clinical management of type 2 diabetes'. Journal of Human Nutrition and Dietetics, . Available Online [DOI] [Details]
Gaoatswe G, Kent BD;Corrigan MA;Nolan G;Hogan AE;McNicholas WT;O'Shea D (2015) 'Invariant Natural Killer T Cell Deficiency and Functional Impairment in Sleep Apnea: Links to Cancer Comorbidity'. Sleep, 38 (10):1629-1634. [DOI] [Details]
Murtagh G, O Connell J;O Connell E;Tallon E;Watson C;Gallagher J;Baugh J;Patle A;O Connell L;Griffin J;O'Hanlon R;Voon V;Ledwidge M;O Shea D;McDonald K (2015) 'Importance of risk factor management in diabetic patients and reduction in Stage B heart failure'. Qjm-An International Journal Of Medicine, 108 (4):307-314. [DOI] [Details]
Lynch, M. and Tobin, A.-M. and Ahern, T. and O'Shea, D. and Kirby, B. (2014) 'Sitagliptin for severe psoriasis'. Clinical and Experimental Dermatology, . Available Online [DOI] [Details]
Yang S, Wang B;Humphries F;Hogan AE;O'Shea D;Moynagh PN (2014) 'The E3 ubiquitin ligase Pellino3 protects against obesity-induced inflammation and insulin resistance'. Immunity, 41 (6):973-987. [DOI] [Details]
Exley MA, Hand L;O'Shea D;Lynch L (2014) 'Interplay between the immune system and adipose tissue in obesity'. Journal of Endocrinology, 223 (2):1-8. [DOI] [Details]
Kiely C, O'Connor E;O'Shea D;Green S;Ega¿¿a M (2014) 'Hemodynamic responses during graded and constant-load plantar flexion exercise in middle-aged men and women with type 2 diabetes'. Journal of Applied Physiology, 117 (7):755-764. [DOI] [Details]
Carolan E, Hogan AE;Corrigan M;Gaotswe G;O'Connell J;Foley N;O'Neill LA;Cody D;O'Shea D (2014) 'The impact of childhood obesity on inflammation, innate immune cell frequency, and metabolic microRNA expression'. Journal of Clinical Endocrinology and Metabolism, 99 (3):1-8. [DOI] [Details]
Boland MR, Lowery AJ;Walsh S;Beddy D;Prichard RS;O'Shea D;Skehan SJ;McDermott EW (2014) 'Incidental Phaeochromocytoma on Staging PET-CT in a Patient with a Sigmoid Tumour and Situs Inversalis Totalis'. Case reports in surgery, 2014 . [DOI] [Details]
Murtagh G, O Connell J, O Connell E, Tallon E, Watson C, Gallagher J, Baugh J, Patle A, O Connell L, Griffin J, O' Hanlon R, Voon V, Ledwidge M, O Shea D, McDonald K (2014) 'Importance of Risk Factor Management in Diabetic Patients & Reduction in Stage B Heart Failure'. Quarterly Journal of Medicine, . [Details]
Ahern T, Khattak A;O'Malley E;Dunlevy C;Kilbane M;Woods C;McKenna MJ;O'Shea D (2014) 'Association between vitamin D status and physical function in the severely obese'. Journal of Clinical Endocrinology and Metabolism, 99 (7):1-31. [DOI] [Details]
O'Shea, D. and O'Connell, J. (2014) 'Cystic fibrosis related diabetes'. Current Diabetes Reports, 14 (8). Available Online [DOI] [Details]
Church, H.A. and O'Shea, D. and Lucey, J.V. (2014) 'Parent-child relationships in gender identity disorder'. Irish Journal of Medical Science, 183 (2):277-281. Available Online [DOI] [Details]
Tynan, G.A. and Hearnden, C.H. and Oleszycka, E. and Lyons, C.L. and Coutts, G. and O'Connell, J. and Corrigan, M.A. and Lynch, L. and Campbell, M. and Callanan, J.J. and Mok, K.H. and Geoghegan, J. and O'Farrelly, C. and Allan, S.M. and Roche, H.M. and O'Shea, D.B. and Lavelle, E.C. (2014) 'Endogenous oils derived from human adipocytes are potent adjuvants that promote IL-1α-dependent inflammation'. Diabetes, 63 (6):2037-2050. Available Online [DOI] [Details]
Judge, C. and O'Donovan, C. and Callaghan, G. and Gaoatswe, G. and O'Shea, D. (2014) 'Gender dysphoria - prevalence and co-morbidities in an Irish adult population'. Frontiers in Endocrinology, 5 (JUN). Available Online [DOI] [Details]
Hogan, A.E. and Gaoatswe, G. and Lynch, L. and Corrigan, M.A. and Woods, C. and O'Connell, J. and O'Shea, D. (2014) 'Glucagon-like peptide 1 analogue therapy directly modulates innate immune-mediated inflammation in individuals with type 2 diabetes mellitus'. Diabetologia, 57 (4):781-784. Available Online [DOI] [Details]
Breen, C. and Ryan, M. and Mcnulty, B. and Gibney, M.J. and Canavan, R. and O'shea, D. (2014) 'High saturated-fat and low-fibre intake: A comparative analysis of nutrient intake in individuals with and without type 2 diabetes'. Nutrition and Diabetes, 4 (FEBRUARY). Available Online [DOI] [Details]
Gillespie, P. and Oshea, E. and O'Hara, M.C. and Dinneen, S.F. and Daly, L. and Heller, S. and Courtney, C.H. and O'Shea, D. and Smith, D. and McGurk, C. and Murphy, K. and O'Shea, E. and Casey, D. and Lawton, J. and White, F.F. and Newell, J. and Byrne, M. and Clark, M. and Cooke, D. and McDonnell, B. and Cunningham, A. and Murphy, C. and Heverin, C. and Monaghan, C. and O'Malley, R. and Fanning, E. and Brown, S. and Twamley, H. and O'Scannail, M. and Breen, C. and McCarthy, K. and Rhynehart, A. and Cannon, E. and O'Brien, J. and Dingle, C. and Harkin, P. and Quinn, C. and Wallace, N. and Kildunne, J. and Moran, M. and Devine, H. and Brown, P. and O'Grady, O. and O'Connor, K. and Fitzgerald, A. and McErlean, U. and Gillen, N. and McNeill, M. and Canavan, E. and Dunlop, L. and Boocock, R. (2014) 'Cost effectiveness of group follow-up after structured education for type 1 diabetes: A cluster randomised controlled trial'. Trials, 15 (1). Available Online [DOI] [Details]
O'Shea, D. and Corrigan, M. and Dunne, M.R. and Jackson, R. and Woods, C. and Gaoatswe, G. and Moynagh, P.N. and O'Connell, J. and Hogan, A.E. (2013) 'Changes in human dendritic cell number and function in severe obesity may contribute to increased susceptibility to viral infection'. International Journal of Obesity, 37 (11):1510-1513. Available Online [DOI] [Details]
Tobin, A.-M. and Ahern, T. and Rogers, S. and Collins, P. and O'Shea, D. and Kirby, B. (2013) 'The dermatological consequences of obesity'. International Journal of Dermatology, 52 (8):927-932. Available Online [DOI] [Details]
Dinneen, S.F., O' Hara, M.C., Byrne, M., Smith, D., Courtney, C.H., McGurk, C., Heller, S., Newell, J., Coffey, N., Breen, C., O' Scannail, M. and O' Shea, D. (2013) 'Group follow-up compared to individual clinic visits after structured education for type 1 diabetes: a cluster randomised controlled trial'. Diabetes Research and Clinical Practice, . [Details]
Briggs AD, Mytton OT, Madden D, O Shea D, Rayner M, Scarborough P (2013) 'The potential impact on obesity of a 10% tax on sugar-sweetened beverages in Ireland, an effect assessment modelling study'. Public Health, 13 (1). [DOI] [Details]
Grosset, J.-F. and Crowe, L. and de Vito, G. and O'Shea, D. and Caulfield, B. (2013) 'Comparative effect of a 1 h session of electrical muscle stimulation and walking activity on energy expenditure and substrate oxidation in obese subjects'. Applied Physiology, Nutrition and Metabolism, 38 (1):57-65. Available Online [DOI] [Details]
Glynn, N. and Keane, F. and O'Shea, D. and Geoghegan, J. and Smith, D. (2013) 'Hypoglycaemia-more than skin deep'. QJM, 106 (4):365-366. Available Online [DOI] [Details]
Breen, C. and Ryan, M. and Gibney, M.J. and Corrigan, M. and O'Shea, D. (2013) 'Glycemic, Insulinemic, and Appetite Responses of Patients With Type 2 Diabetes to Commonly Consumed Breads'. Diabetes Educator, 39 (3):376-386. Available Online [DOI] [Details]
Neff, K.J. and O'Shea, D. and le Roux, C.W. (2013) 'Glucagon like peptide-1 (GLP-1) dynamics following bariatric surgery: A signpost to a new frontier'. Current Diabetes Reviews, 9 (2):93-101. Available Online [Details]
Mangan, B.A. and Dunne, M.R. and O'Reilly, V.P. and Dunne, P.J. and Exley, M.A. and O'Shea, D. and Scotet, E. and Hogan, A.E. and Doherty, D.G. (2013) 'Cutting edge: CD1d restriction and Th1/Th2/Th17 cytokine secretion by human Vδ3 T cells'. Journal of Immunology, 191 (1):30-34. Available Online [DOI] [Details]
Reid, C.T. and Tobin, A.M. and Ahern, T. and O'Shea, D. and Kirby, B. (2013) 'Liraglutide in combination with acitretin for severe recalcitrant psoriasis'. British Journal of Dermatology, 169 (1):230-231. Available Online [DOI] [Details]
Murray, A.E. and McMorrow, A.M. and O'Connor, E. and Kiely, C. and Mac Ananey, O. and O'Shea, D. and Egaña, M. and Lithander, F.E. (2013) 'Dietary quality in a sample of adults with type 2 diabetes mellitus in Ireland; A cross-sectional case control study'. Nutrition Journal, 12 (1). Available Online [DOI] [Details]
O'Connell, K. and Kelly, S. and Kinsella, K. and Jordan, S. and Kenny, O. and Murphy, D. and Heffernan, E. and O'Laoide, R. and O'Shea, D. and McKenna, C. and Cassidy, L. and Fletcher, J. and Walsh, C. and Brady, J. and McGuigan, C. and Tubridy, N. and Hutchinson, M. (2013) 'Dose-related effects of vitamin D on immune responses in patients with clinically isolated syndrome and healthy control participants: Study protocol for an exploratory randomized double- blind placebo-controlled trial'. Trials, 14 (1). Available Online [DOI] [Details]
Briggs, A.D.M. and Mytton, O.T. and Madden, D. and O'Shea, D. and Rayner, M. and Scarborough, P. (2013) 'The potential impact on obesity of a 10% tax on sugar-sweetened beverages in Ireland, an effect assessment modelling study'. BMC Public Health, 13 (1). Available Online [DOI] [Details]
Tamagno, G. and Sheahan, K. and Skehan, S.J. and Geoghegan, J.G. and Fennelly, D. and Collins, C.D. and Maguire, D. and Traynor, O. and Brophy, D.P. and Cantwell, C. and Swan, N. and McGowan, L. and O'Toole, D. and O'Shea, D. (2013) 'Initial impact of a systematic multidisciplinary approach on the management of patients with gastroenteropancreatic neuroendocrine tumor'. Endocrine, 44 (2):504-509. Available Online [DOI] [Details]
Ahern, T. and Tobin, A.-M. and Corrigan, M. and Hogan, A. and Sweeney, C. and Kirby, B. and O'Shea, D. (2013) 'Glucagon-like peptide-1 analogue therapy for psoriasis patients with obesity and type 2 diabetes: A prospective cohort study'. Journal of the European Academy of Dermatology and Venereology, 27 (11):1440-1443. Available Online [DOI] [Details]
Hassan, S.J. and O'Shea, D. (2012) 'Weight management services for adults' highlighting the role of primary care'. Irish Medical Journal, 105 (10). Available Online [Details]
Sahebally, S.M. and Burke, J.P. and O'Shea, D. and Geoghegan, J. (2012) 'The effect of gastric band slippage on patient body mass index and quality of life'. Obesity Surgery, 22 (5):773-776. Available Online [DOI] [Details]
Macananey, O. and O'Shea, D. and Warmington, S.A. and Green, S. and Egaña, M. (2012) 'Gymnasium-based unsupervised exercise maintains benefits in oxygen uptake kinetics obtained following supervised training in type 2 diabetes'. Applied Physiology, Nutrition and Metabolism, 37 (4):599-609. Available Online [DOI] [Details]
Lynch, L. and Nowak, M. and Varghese, B. and Clark, J. and Hogan, A. and Toxavidis, V. and Balk, S. and O'Shea, D. and O'Farrelly, C. and Exley, M. (2012) 'Adipose Tissue Invariant NKT Cells Protect against Diet-Induced Obesity and Metabolic Disorder through Regulatory Cytokine Production'. Immunity, 37 (3):574-587. Available Online [DOI] [Details]
Tamagno, G. and O'Shea, D. (2012) 'Anatomical localization of insulinomas: Still a need to combine a set of diagnostic procedures'. Hormones, 11 (4):483-487. Available Online [Details]
Farah, N. and Hogan, A.E. and O'Connor, N. and Kennelly, M.M. and O'Shea, D. and Turner, M.J. (2012) 'Correlation between maternal inflammatory markers and fetomaternal adiposity'. Cytokine, 60 (1):96-99. Available Online [DOI] [Details]
Brogan A, Hevey D, O'Callaghan G, Yoder R, O'Shea D; (2011) 'Impaired decision making among morbidly obese adults'. 70 (2):189-186. Available Online [DOI] [Details]
Hogan AE, Corrigan MA, O'Reilly V, Gaoatswe G, O'Connell J, Doherty DG, Lynch L, O'Shea D; (2011) 'Cigarette smoke alters the invariant natural killer T cell function and may inhibit anti-tumor responses'. Clinical Immunology, 140 (3):229-235. Available Online [DOI] [Details]
Hogan AE, Tobin AM, Ahern T, Corrigan MA, Gaoatswe G, Jackson R, O'Reilly V, Lynch L, Doherty DG, Moynagh PN, Kirby B, O'Connell J, O'Shea D.; (2011) 'Glucagon-like peptide-1 (GLP-1) and the regulation of human invariant natural killer T cells: lessons from obesity, diabetes and psoriasis'. Diabetologia, 54 (11):2745-2754. Available Online [DOI] [Details]
O'Connell J, Lynch L, Hogan A, Cawood TJ, O'Shea D.; (2011) 'Preadipocyte factor-1 is associated with metabolic profile in severe obesity'. J Clin Endocrinol Metab, 96 (4):680-684. Available Online [Details]
O'Shea D, Cawood TJ, O'Farrelly C, Lynch L.; (2010) 'Natural killer cells in obesity: impaired function and increased susceptibility to the effects of cigarette smoke'. PLoS ONE, 25 (5). Available Online [DOI] [Details]
Dennedy MC, Smith D, O'Shea D, McKenna TJ.; (2010) 'Investigation of patients with atypical or severe hyperandrogenaemia including androgen-secreting ovarian teratoma'. European journal of endocrinology / European Federation of Endocrine Societies Links, 162 (2):213-220. [Details]
Cawood TJ, Bashir M, Brady J, Murray B, Murray PT, O'Shea D.; (2010) 'Urinary collagen IV and πGST: potential biomarkers for detecting localized kidney injury in diabetes--a pilot study'. American Journal of Nephrology, . Available Online [DOI] [Details]
O'Connell J, Lynch L, Cawood TJ, Kwasnik A, Nolan N, Geoghegan J, McCormick A, O'Farrelly C, O'Shea D.; (2010) 'The relationship of omental and subcutaneous adipocyte size to metabolic disease in severe obesity'. PLoS ONE, 1 (5):e9997. Available Online [Details]
O'Connell J, Kieran P, Gorman K, Ahern T, Cawood TJ, O'Shea D.; (2010) 'BMI > or = 50 kg/m2 is associated with a younger age of onset of overweight and a high prevalence of adverse metabolic profiles'. Public Health Nutrition, 13 (7):1090-1098. Available Online [DOI] [Details]
Lynch LA, O'Connell JM, Kwasnik AK, Cawood TJ, O'Farrelly C, O'Shea DB.; (2009) 'Are natural killer cells protecting the metabolically healthy obese patient?'. Obesity, 17 (3):601-605. Available Online [DOI] [Details]
Dillon MF, Curran J, Martos R, Walsh C, Walsh J, Al-Azawi D, Lee CS, O'Shea D.; (2008) 'Factors that affect longevity of intravenous cannulas: a prospective study'. Qjm-Monthly Journal of the Association of Physicians, 101 (9):731-735. Available Online [DOI] [Details]
Cawood T, Moriarty P, O'Farrelly C, O'Shea D. ; (2007) 'Smoking and thyroid associated ophthalmopathy; a novel explanation of the biological link'. Journal of Clinical Endocrinology and Metabolism, 92 (1):59-64. Available Online [DOI] [Details]
DF Waterhouse, AM McLaughlin, D O¿Shea; (2007) 'An examination of the relationship between normal range thyrotropin and cardiovascular risk parameters: a study in healthy women'. Thyroid, 17 (3):243-248. [Details]
A Quinn, C Doody, D O¿Shea; (2007) 'The effect of a physical activity education programme on physical activity, fitness, quality of life and attitudes to exercise in obese females'. Journal of Science and Medicine in Sport, 11 (5):469-472. Available Online [DOI] [Details]
Quinn, A, Doody C, O'Shea D ; (2007) 'The effect of an 18 week group exercise education program on weight, physical activity, cardiovascular fitness, quality of life and attitudes to exercise in obese Irish female adults'. Journal of Science and Medicine in Sport, [Epub ahead of print] . [Details]
Tuthill A, Quinn A, McColgan D, McKenna M, O'shea D, McKenna TJ.; (2007) 'A prospective randomized controlled trial of lifestyle intervention on quality of life and cardiovascular risk score in patients with obesity and type 2 diabetes'. Diabetes, Obesity and Metabolism, . [Details]
Cawood TJ, Moriarty P, O'Farrelly C, O'Shea D.; (2006) 'The effects of TNFα and IL1 on an in vitro model of thyroid associated ophthalmopathy; contrasting effects on adipogenesis'. European Journal of Endocrinology, 155 (3):395-403. [Details]
Cawood TJ, McKenna MJ, Gallagher CG, Smith D, Chung WY, Gibney J, O'Shea D. ; (2006) 'Cystic Fibrosis-Related Diabetes in Adults'. Irish Medical Journal, 99 (3):83-86. [Details]
O'Shea D, Cawood TJ, McKenna MJ, Gallagher CG, Smith D, Wen YC, Gibney J, Dodd JD, ; (2005) 'Oral bisphosphonates improve Bone Mineral Density in adults with cystic fibrosis'. Irish Medical Journal, 98 (9):270-273. [Details]
Dhillo, W.S. and Kong, W.M. and Le Roux, C.W. and Alaghband-Zadeh, J. and Jones, J. and Carter, G. and Mendoza, N. and Meeran, K. and O'Shea, D. (2002) 'Cortisol-binding globulin is important in the interpretation of dynamic tests of the hypothalamic-pituitary-adrenal axis'. European Journal of Endocrinology, 146 (2):231-235. Available Online [Details]
 

Conference Publications

Doherty K, Ahern T, Billfalk-Kelly A, Maeve D, Fitzpatrick P,Gilroy I, Mulholland U, Rossiter E, O¿Shea D, Kelleher CC. (2011) Health professionals are not systematic in obesity detection and measurement . In: Journal of Epidemiology & Community Health eds. IEA World Congress of Epidemiology, Edinburgh Edinburgh, , 07-AUG-11 - 11-AUG-11 , pp.Suppl 1: A329-Suppl 1: A329 [Details]
Grosset JF, Crowe L, De Vito G, O¿Shea D, Caulfield B; (2009) Effect of a bout of 1h electrical muscle stimulation on substrate oxidation in obese subjects vs walking activity 14th European College Spoprts Science Oslo, , 24-JUN-09 - 29-JUN-09 [Details]
Grosset JF, O¿Shea D, Crowe L, Minogue C, Caulfield B.; (2008) Electrical muscle stimulation can be used to elicit cardiovascular exercise response at training intensities in obese adults Proceedings of XIII International FES Society Conference, Freiburg, Germany , 21-SEP-08 - 25-SEP-08 [Details]
                       

Abstract

Breen, C,Ryan, M,McNulty, B,Gibney, MJ,O'Shea, D (2013) Carbohydrate confusion in Type 2 diabetes: quantity not quality prevails. Abstract [Details]
Kennedy, C,Romero-Ortuno, R,Robinson, D,O'Shea, D,O'Shea, D,Kenny, RA,O'Connell, J (2012) Cognitive Outcomes of Metabolically Healthy Obese (MHO) Older Persons. Abstract [Details]
Doherty, K,Ahern, T,Billfalk-Kelly, A,Maeve, D,Fitzpatrick, P,Gilroy, I,Mulholland, U,Rossiter, E,O'Shea, D,Kelleher, C (2011) HEALTH PROFESSIONALS ARE NOT SYSTEMATIC IN OBESITY DETECTION AND MEASUREMENT. Abstract [DOI] [Details]
Tamagno, G,McGowan, L,Phelan, S,Sheahan, K,O'Shea, D (2010) The Clinical Challenge of Patients with a Thoracic or Neck Neuroendocrine Tumor: A Retrospective Analysis from a Single Irish Institution. Abstract [Details]
Moran, C,Tamagno, G,O'Shea, D (2010) Localising Insulinomas: A Persistent Challenge. Abstract [Details]
                                                               

Research

Research Interests

The Obesity Immunology group¿s research is focused on immune system dysregulation in obese adults and children.  We are primarily interested in cells of the innate immune system; invariant natural killer T cells (iNKT cells), MAIT cells, Vδ3 T cells, Natural Killer cells (NK) and Dendritic cells (Dc) and the effect of gut hormones and diabetes medications on cell function. These cells are impacted by the obese condition. We have recently published that obese children express increased levels of microRNA molecules (mir) involved in insulin signalling and metabolic regulation. We have found that NK cytotoxicty is reduced in both obese adults and children in comparison to their non-obese counterparts. In correlation with this we have found that mir34; associated with tumour suppression is down regulated in obese children.

Research Projects

Sponsor : Bray Lions Club
Title : Glycaemic and Insulin Responses of Subjects with and without Diabetes to Various Staple Carbohydrate-Rich Foods in the Irish Diet
Start Date / End Date : 01-SEP-08 / 31-AUG-10
Sponsor : Health Research Board (HRB)
Title : Smoking and the Development of Diabetes
Start Date / End Date : 01-DEC-08 / 01-DEC-11
Sponsor : Dept. of Agriculture, Fisheries & Food (DAFF)
Title : National Nutrition Phenotype Database
Start Date / End Date : 01-JUL-08 / 31-DEC-13
Sponsor : Irish Heart Foundation
Title : The Effect of Sex Hormones on Lymphocyte, Adipose Tissue and Vascular Tissue Inflammation in Men with Obesity or Cardiovascular disease
Start Date / End Date : 01-OCT-09 / 28-FEB-13
Sponsor : Sanofi Aventis
Title : Investigation of innate immune dysregulation in obesity
Start Date / End Date : 01-SEP-08 / 30-APR-11
Sponsor : University College Dublin Foundation Ltd.
Title : Gut Endocrine Tumours
Start Date / End Date : 01-AUG-10 / 31-JAN-12
Sponsor : University College Dublin Foundation Ltd.
Title : The interaction between steroid hormones & immune cells in metabolically healthy obese and metabolically unhealthy obese patients & the response to weight loss following bariatric surgery.
Start Date / End Date : 01-JUL-11 / 09-SEP-14
Sponsor : University College Dublin Foundation Ltd.
Title : Ipsen Newman Fellowship in Gut Neuroendocrine Tumours
Start Date / End Date : 01-MAR-11 / 28-FEB-13
Sponsor : Health Research Board (HRB)
Title : Effect of Glucagon like peptide-1 therapy on obesity driven inflammation and co-morbid inflammatory conditions
Start Date / End Date : 01-FEB-15 / 31-JAN-18
Sponsor : Merck Sharp & Dohme (Ireland)
Title : Dipeptidyl peptidase-4 Inhibition in Psoriasis patients with diabetes (DIP): A Randomized Clincal Trial
Start Date / End Date : 08-NOV-13 / 30-SEP-15
Sponsor : University College Dublin Foundation Ltd.
Title : Role of Innate T cells in Obese Type 2 Diabetes
Start Date / End Date : 01-OCT-13 / 30-SEP-15
Sponsor : University College Dublin (UCD)
Title : School Funded Research Account
Start Date / End Date : 16-DEC-13 / 15-DEC-14
 

Current Postgraduate Students

Aisling O Brien, Doctor of Philosophy (PhD)   -   Thesis Supervisor
Mohd Mat, Doctor of Philosophy (PhD)   -   Thesis Supervisor
Samuel Lee, Medicine (MB BCh BAO)   -   Thesis Supervisor