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Researchers at UCD

researcher

Geraldine McCarthy

Clinical Professor

School Of Medicine
Mater Hospital
Eccles Street
Dublin 7

Tel:
Email: g.mccarthy@ucd.ie

Biography

Professor Geraldine McCarthy has ongoing collaboration with DCU Biomedical Diagnostics Institute project MobiMate (mobile-phone enabled remote chronic disease management) funded by Enterprise Ireland, PI Dr Conor Burke. Continuation of collaboration with Prof Dermot Kenny RCSI on platelet hyperreactivity in inflammatory arthritis. Continuation of collaboration with Dr Aisling Dunne/Prof Kingston Mills at TCD in relation to the pathologic effects of BCP crystals in osteoarthritis. Collaboration with Dr Eamonn Molloy St Vincents University Hospital and Prof Conor Murphy RVEEH in relation to giant cell arteritis. She is currently a PI in an international study of gout (SUGAR) funded by the American College of Rheumatology and the European League Against Rheumatism. She is a member of a taskforce for the revision of EULAR fibromyalgia management guidelines. She has established  Eiregout, a subsidiary of the European Gout Genetics Consortium (EuroGout) for the recruitment of a very large well ascertained gout sample set for use in genome-wide genetic studies, in collaboration with Dr Tony Merriman, University of Otago, Dunedin, New Zealand.

 

Member of the Fibrosis Research Theme

Publications

 

Book Chapters

Molloy ES, McCarthy GM. ; (2006) 'Biochemistry of Apatite-associated Syndromes' In: Wortmann RL, Schumacher HR, Becker MA, Ryan LM (eds). Crystal-induced arthropathies; Gout, pseudogout and apatite associated syndromes. New York: Marcel Dekker. [Details]
McCarthy GM. ; (1999) 'Crystal-related tissue damage' In: ISmith CJ, Holers VM (eds). Gout, Hyperuricemia and Crystal-associated Arthropathies. New York, NY: Marcel Dekker, Inc. , pp.39-57 [Details]
McCarthy GM; (1997) 'Apatite deposition diseases' In: : Klippel JH, Dieppe PE (Eds): (eds). Rheumatology 2nd ed. London UK: Mosby-Wolfe. [Details]
McCarthy GM, McCarty DJ; (1997) ' Hyperuricemia and gout. ' In: Conn RB, Borer WZ, Snyder JW (Eds) (eds). Current Diagnosis. Philadelphia, PA: WB Saunders Co;. , pp.698-702 [Details]
 

Peer Reviewed Journals

Taylor WJ, Fransen J;Dalbeth N;Neogi T;Ralph Schumacher H;Brown M;Louthrenoo W;Vazquez-Mellado J;Eliseev M;McCarthy G;Stamp LK;Perez-Ruiz F;Sivera F;Ea HK;Gerritsen M;Scire CA;Cavagna L;Lin C;Chou YY;Tausche AK;da Rocha Castelar-Pinheiro G;Janssen M;Chen JH;Slot O;Cimmino M;Uhlig T;Jansen TL (2016) 'Diagnostic Arthrocentesis for Suspicion of Gout Is Safe and Well Tolerated'. Journal of Rheumatology, 43 (1):150-153. [DOI] [Details]
O'Neill L, Rooney P;Molloy D;Connolly M;McCormick J;McCarthy G;Veale DJ;Murphy CC;Fearon U;Molloy E (2015) 'Regulation of Inflammation and Angiogenesis in Giant Cell Arteritis by Acute-Phase Serum Amyloid A'. Arthritis & rheumatology, 67 (9):2447-2456. [DOI] [Details]
Stack J, McCarthy G (2015) 'Basic calcium phosphate crystals and osteoarthritis pathogenesis: novel pathways and potential targets'. Current Opinion in Rheumatology, . [DOI] [Details]
de Lautour H, Taylor WJ;Adebajo A;Alten R;Burgos-Vargas R;Chapman P;Cimmino MA;da Rocha Castelar Pinheiro G;Day R;Harrold LR;Helliwell P;Janssen M;Kerr G;Kavanaugh A;Khanna D;Khanna PP;Lin C;Louthrenoo W;McCarthy G;Vazquez-Mellado J;Mikuls TR;Neogi T;Ogdie A;Perez-Ruiz F;Schlesinger N;Schumacher HR;Scir¿¿ CA;Singh JA;Sivera F;Slot O;Stamp LK;Tausche AK;Terkeltaub R;Uhlig T;van de Laar M;White D;Yamanaka H;Zeng X;Dalbeth N (2015) 'Development of Preliminary Remission Criteria for Gout Using Delphi and 1000Minds¿¿ Consensus Exercises'. Arthritis Care and Research, . [DOI] [Details]
Stack J, Ryan J;McCarthy G (2015) 'Colchicine: New Insights to an Old Drug'. American Journal of Therapeutics, 22 (5):1-7. [DOI] [Details]
French HP, Galvin R;Cusack T;McCarthy GM (2014) 'Predictors of short-term outcome to exercise and manual therapy for people with hip osteoarthritis'. Physical Therapy, 94 (1):31-39. [DOI] [Details]
Taylor WJ, Fransen J;Dalbeth N;Neogi T;Schumacher HR;Brown M;Louthrenoo W;Vazquez-Mellado J;Eliseev M;McCarthy G;Stamp LK;Perez-Ruiz F;Sivera F;Ea HK;Gerritsen M;Scire C;Cavagna L;Lin C;Chou YY;Tausche AK;da Rocha Castelar-Pinheiro G;Janssen M;Chen JH;Slot O;Cimmino M;Uhlig T;Jansen TL (2014) 'Performance of classification criteria for gout in early and established disease'. Annals of the Rheumatic Diseases, . [DOI] [Details]
Cotter AG, Sabin CA;Simelane S;Macken A;Kavanagh E;Brady JJ;McCarthy G;Compston J;Mallon PW; (2014) 'Relative contribution of HIV infection, demographics and body mass index to bone mineral density'. AIDS, 28 (14):2051-2060. [DOI] [Details]
Chhana A, Callon KE;Dray M;Pool B;Naot D;Gamble GD;Coleman B;McCarthy G;McQueen FM;Cornish J;Dalbeth N (2014) 'Interactions between tenocytes and monosodium urate monohydrate crystals: implications for tendon involvement in gout'. Annals of the Rheumatic Diseases, 73 (9):1737-1741. [DOI] [Details]
McCarthy EM, MacMullan PA;Al-Mudhaffer S;Madigan A;Donnelly S;McCarthy CJ;Molloy ES;Kenny D;McCarthy GM (2014) 'Plasma fibrinogen along with patient-reported outcome measures enhances management of polymyalgia rheumatica: a prospective study'. Rheumatology, 41 (5):931-937. [DOI] [Details]
Durcan L, Bolster F;Kavanagh EC;McCarthy GM (2014) 'The structural consequences of calcium crystal deposition'. Rheumatic Disease Clinics of North America, 40 (2):311-328. [DOI] [Details]
Prowse, RL,Dalbeth, N,Kavanaugh, A,Adebajo, AO,Gaffo, AL,Terkeltaub, R,Mandell, BF,Suryana, BPP,Goldenstein-Schainberg, C,Diaz-Torne, C,Khanna, D,Liote, F,Mccarthy, G,Kerr, GS,Yamanaka, H,Janssens, H,Baraf, HF,Chen, JH,Vazquez-Mellado, J,Harrold, LR,Stamp, LK,Van de Laar, MA,Janssen, M,Doherty, M,Boers, M,Edwards, NL,Gow, P,Chapman, P,Khanna, P,Helliwell, PS,Grainger, R,Schumacher, HR,Neogi, T,Jansen, TL,Louthrenoo, W,Sivera, F,Taylor, WJ (2013) 'A Delphi Exercise to Identify Characteristic Features of Gout - Opinions from Patients and Physicians, the First Stage in Developing New Classification Criteria'. Journal of Rheumatology, 40 :498-505. [DOI] [Details]
MacMullan PA, McCarthy GM; (2010) 'The meniscus, calcification and osteoarthritis: a pathologic team'. Arthritis Research and Therapy, 12 (3). [DOI] [Details]
Mac Mullan PA, Peace AJ, Madigan AM, Tedesco AF, Kenny D, McCarthy GM; (2010) 'Platelet hyper-reactivity in active inflammatory arthritis is unique to the adenosine diphosphate pathway: a novel finding and potential therapeutic target'. Rheumatology [formerly the British journal of rheumatology], 49 (2):240-245. [DOI] [Details]
McCarthy GM, Cheung HS; (2009) 'Point: Hydroxyapatite crystal deposition is intimately involved in the pathogenesis and progression of human osteoarthritis'. Current Rheumatology Reports, 11 (2):141-147. [Details]
Murphy G, Coughlan R, Devlin J, FitzGerald O, McCarthy G; (2009) 'Recommendations for the therapeutics of methotrexate in rheumatoid arthritis'. Irish Medical Journal, . [Details]
French HP, Cusack T, Brennan A, White B, Gilsenan C, Fitzpatrick M, O'Connell P, Kane D, Fitzgerald O, McCarthy GM; (2009) 'Exercise and manual physiotherapy arthritis research trial (EMPART): a multicentre randomised controlled trial'. BMC Musculoskeletal Disorders, 10 . [DOI] [Details]
McCarthy GM; (2009) 'Inspirational calcification: how rheumatology research directs investigation in vascular biology'. Current Opinion in Rheumatology, 21 (1):47-49. [DOI] [Details]
Molloy, ES,Morgan, MP,Doherty, GA,McDonnell, B,O'Byrne, J,Fitzgerald, DJ,McCarthy, GM; (2009) 'Microsomal prostaglandin E-2 synthase 1 expression in basic calcium phosphate crystal-stimulated fibroblasts: role of prostaglandin E-2 and the EP4 receptor'. Osteoarthritis and Cartilage, 17 :686-692. [DOI] [Details]
Molloy, ES,Morgan, MP,Doherty, GA,McDonnell, B,O'Byrne, J,Fitzgerald, DJ,McCarthy, GM; (2008) 'Mechanism of basic calcium phosphate crystal-stimulated matrix metalloproteinase-13 expression by osteoarthritic synovial fibroblasts: inhibition by prostaglandin E-2'. Annals of the Rheumatic Diseases, 67 :1773-1779. [DOI] [Details]
McCarthy GM, Molloy ES, Morgan MP, Doherty GA, McDonnell B, Hilliard M, O'Byrne J, Fitzgerald DJ, ; (2008) 'Mechanism of basic calcium phosphate crystal-stimulated cyclo-oxygenase-1 up-regulation in osteoarthritic synovial fibroblasts'. Rheumatology, . [DOI] [Details]
Carville SF, Arendt-Nielsen S, Bliddal H, Blotman F, Branco JC, Buskilla D, Da Silva JAP, Danneskiold-Samsøe B, Dincer F, Henriksson C, Henriksson K, Kosek K, Longley K, McCarthy GM, Perrot S, Puszczewicz MJ, Sarzi-Puttini P, Silman A, Späth M, Choy EH. ; (2007) 'EULAR evidence based recommendations for the management of fibromyalgia syndrome'. Annals of Rheumatic Diseases, . [Details]
Nadra I, Boccaccini AR, Philippidis P, Whelan LC, McCarthy GM, Haskard DO, Landis RC. ; (2007) 'Effect of particle size on basic calcium phosphate crystal stimulation of macrophage TNFa release'. Atherosclerosis, . [Details]
Jordan, NP; Staines, A; Ryan, J; McCarthy, CJ; McCarthy, GM; ; (2006) 'Neurostructural integration technique: An effective therapy in the management of fibromyalgia'. Rheumatology, 45 (NA):109-110. [Details]
Jordan N, McCarthy GM.; (2006) 'Febuxostat: a safe and effective therapy for hyperuricemia and gout'. Future Rheumatology, 1 :303-309. [Details]
Molloy ES, McCarthy GM. ; (2006) 'Calcium crystal deposition disease ' update in pathogenesis and manifestations'. Rheumatic Diseases Clinics of North America, 32 :383-400. [Details]
McCarthy GM. ; (2006) 'New drugs for crystal deposition diseases'. Current Opinion in Rheumatology, 18 :170. [Details]
Zhang, W.,Doherty, M.,Pascual, E.,Bardin, T.,Barskova, V.,Conaghan, P.,Gerster, J.,Jacobs, J.,Leeb, B.,Liote, F.,McCarthy, G.,Netter, P.,Nuki, G.,Perez-Ruiz, F.,Pignone, A.,Pimentao, J.,Punzi, L.,Roddy, E.,Uhlig, T.,Zimmermann-Gorska, I.; (2006) 'EULAR evidence based recommendations for gout. Part I: Diagnosis. Report of a task force of the Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT)'. Ann Rheum Dis, 65 (10):1301-11. [Details]
Molloy ES, McCarthy GM; (2006) 'Basic calcium phosphate crystals: pathways to joint Degeneration'. Current Opinion in Rheumatology, 18 :187-192. [Details]
Molloy, ES; Morgan, MP; Doherty, GA; O'Byrne, J; Fitzgerald, DJ; McCarthy, GM; ; (2005) 'Mechanism of cyclooxygenase induction by basic calcium phosphate crystals in osteoarthritic synovial fibroblasts'. Arthritis and Rheumatism, 52 (9):100-101. [Details]
Molloy, ES; Morgan, MP; Doherty, GA; O'Byrne, J; Fitzgerald, DJ; McCarthy, GM; ; (2005) 'Mechanism of basic calcium phosphate crystal-induced Upregulation of matrix metalloproteinase-13 in human osteoarthritic synovial fibroblasts: Effect of prostaglandin E2+'. Arthritis and Rheumatism, 52 (9):101-101. [Details]
Morgan, M. P.,Whelan, L. C.,Sallis, J. D.,McCarthy, C. J.,Fitzgerald, D. J.,McCarthy, G. M.; (2004) 'Basic calcium phosphate crystal-induced prostaglandin E2 production in human fibroblasts: role of cyclooxygenase 1, cyclooxygenase 2, and interleukin-1beta'. Arthritis Rheum, 50 (5):1642-9. [Details]
O'Mahony MC, Cassidy JP, Callanan JJ, McCarthy G, ; (2002) 'Myocarditis in sibling boxer puppies associated with Citrobacter koseri infection'. Veterinary Pathology, 39 (3):393-395. [Details]
Morgan, MP,Cooke, MM,Christopherson, PA,Westfall, PR,McCarthy, GM; (2001) 'Calcium hydroxyapatite promotes mitogenesis and matrix metalloproteinase expression in human breast cancer cell lines'. Journal of Carcinogenesis, 32 :111-117. [Details]
 

Conference Publications

French H., Cusack T., Brennan A. Caffrey A., Cuddy V., Fitzpatrick M., FitzGerald O., Gilsenan C., Kane D., O'Connell P., White B.6, McCarthy G.; (2011) THE EFFECTIVENESS OF EXERCISE WITH AND WITHOUT MANUAL THERAPY FOR HIP OSTEOARTHRITIS: PRELIMINARY RESULTS OF A MULTI-CENTRE RANDOMISED CONTROLLED TRIAL World Confederation for Physical Therapy Amsterdam, , 20-JUN-11 - 23-JUN-11 [Details]
Lowry, D., Burke, T., O'Keeffe, D., McCarthy, G & Crowe J. ; (2010) Specific Neuropsychological and Widespread Psychosocial Impairment in a Fibromyalgia Population. Poster Presentation at 2010 DAMC Young Investigator's Research Symposium DAMC Young Investigator's Research Symposium Dublin, , 19-MAY-10 - 19-MAY-10 [Details]
   

Editorial

Hoffman, GS,Seo, P,McCarthy, G; (2009) Vasculitis syndromes introduction. Editorial [Details]
                                                                                   

Research

 

Research Projects

Sponsor : University College Dublin Foundation Ltd.
Title : Research into Lower Back Pain
Start Date / End Date : 01-JUN-15 / 31-MAY-17
Sponsor : Enterprise Ireland (EI)
Title : Mobile phone-enabled remote chronic disease management- Mobimate
Start Date / End Date : 01-NOV-13 / 23-SEP-14
Sponsor : University College Dublin (UCD)
Title : School Funded Research Account
Start Date / End Date : 01-OCT-14 / 30-SEP-18