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Researchers at UCD

researcher

Gerry Wilson

Professor of Rheumatology

School Of Medicine
Conway Institute
Belfield
Dublin 4

Tel: +353 1 7166801
Email: gerry.wilson@ucd.ie

Biography

Professor Gerry Wilson graduated in Medicine from Queen's University Belfast in 1983. He was awarded an ARC Clinical Fellowship for a PhD thesis which he undertook at the University of Sheffield and successfully completed in 1995. He was subsequently awarded an ARC Copeman Fellowship for research at Stanford University. He was appointed Professor in Rheumatology and Honorary Consultant Rheumatologist at the University of Sheffield Medical School and Sheffield Teaching Hospitals NHS Foundation Trust where he was Head of the Sheffield EULAR Centre of Excellence for Rheumatology.

Prof Wilson was appointed to the Arthritis Ireland/UCD Chair of Rheumatology in 2013. He joins Ireland's leading rheumatology group comprising seven existing consultant rheumatologists based Mater Misericordiae University Hospital and St Vincent's University Hospital. Prof Wilson is the head of the UCD Centre for Arthritis Research.

Professional

 

Associations

Association: Academic Centre for Arthritis and Rheumatic Disease (ACARD), Function/Role: Head
Association: Rheumatoid Arthritis Biologics Register of Ireland (RABRI) , Function/Role: Steering Group
Association: Arthritis Research Coalition, Function/Role: Head
Association: EULAR Centre of Excellence in Rheumatology (2011-2016), Function/Role: Head
Association: UK Rheumatoid Arthritis Genetics (UKRAG) group, Function/Role: Member
Association: Maximising Therapeutic Utility for Rheumatoid Arthritis (MATURA) , Function/Role: Steering Group
Association: Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate (BRAGGSS) , Function/Role: Steering Group
Association: European Medicines Agency , Function/Role: Ad hoc Panel Chair
Association: Commission on Human Medicines Expert Advisory Panel, Function/Role: Member
     

Conference Contributions

Dorris, ER; Creevey, K; Moran, C; Muthana, M; Wilson, G (2016) The rheumatoid arthritis susceptibility gene C5ORF30 acts as an immunomodulator in macrophages. [Oral Presentation], EULAR, London , 08-JUN-16 - 11-JUN-16.

Committees

Committee : Health Products Regulatory Authority (HPRA), Preclinical/Clinical Expert Subcommittee
Committee : Commission on Human Medicines, Expert Advisory Panel
Committee : Heberden Committee of British Society for Rheumatology
 

Education

Year 1986 Institution: Royal College of Physicians UK
Qualification: MRCP Subject:
Year 1983 Institution: Queen's University of Belfast, UK
Qualification: MB, BCh, BAO Subject: Medicine
Year 1988 Institution: Royal College of Physicians, Ir
Qualification: DCH Subject:
Year 1995 Institution: University of Sheffield
Qualification: PhD Subject:
         

Publications

     

Peer Reviewed Journals

Jani M, Isaacs JD, Morgan AW, Wilson AG, Plant D, Hyrich KL, Chinoy H, Barton A. (2017) 'High frequency of antidrug antibodies and association of random drug levels with efficacy in certolizumab pegol-treated patients with rheumatoid arthritis: results from the BRAGGSS cohort'. Annals of the Rheumatic Diseases, 76 (1):208-213. [Details]
Hawtree S, Muthana M, Wilkinson JM, Akil M, Wilson AG (2015) 'Histone Deacetylase 1 Regulates Tissue Destruction In Rheumatoid Arthritis'. Human Molecular Genetics, 24 (19):5367-5377. Available Online [Details]
Meghna Jani, John D Isaacs, Ann W Morgan, Anthony G Wilson, Darren Plant, Kimme L Hyrich, Hector Chinoy, Anne Barton (2016) 'Detection of anti-drug antibodies using a bridging ELISA compared with radioimmunoassay in adalimumab-treated rheumatoid arthritis patients with random drug levels'. Rheumatology, . [DOI] [Details]
Smith, S.L., Plant, D., Eyre, S., Hyrich, K., Morgan, A.W., Wilson, A.G., Isaacs, J.D. and Barton, A. (2017) 'The predictive value of serum S100A9 and response to etanercept is not confirmed in a large UK rheumatoid arthritis cohort'. Rheumatology, . [DOI] [Details]
Muthana M, Hawtree S, Wilshaw A, Linehan E, Roberts H, Khetan S, Adeleke G, Wright F, Akil M, Fearon U, Veale D, Ciani B, Wilson AG (2015) 'C5orf30 is a negative regulator of tissue damage in rheumatoid arthritis'. PNAS, 112 (37):11618-11623. Available Online [Details]
Jani M, Isaacs JD, Morgan AW, Wilson AG, Plant D, Hyrich KL, Chinoy H, Barton A, Prouse PJ, Moitra RK, Shawe DJ. (2016) 'High frequency of antidrug antibodies and association of random drug levels with efficacy in certolizumab pegol-treated patients with rheumatoid arthritis: results from the BRAGGSS cohort'. Annals of the Rheumatic Diseases, . [DOI] [Details]
Smith SL, Plant D, Lee XH, Massey J, Hyrich K, Morgan AW, Wilson AG, Isaacs J, Barton A. (2016) 'Previously reported PDE3A-SLCO1C1 genetic variant does not correlate with anti-TNF response in a large UK rheumatoid arthritis cohort'. Pharmacogenomics, 17 (7):715-720. [DOI] [Details]
Jani M, Isaacs J, Morgan AW, Wilson AG, Plant D, Hyrich KL, Chinoy H, Barton A. (2016) 'Utility of detecting anti-drug antibodies using a bridging ELISA compared to radioimmunoassay in adalimumab treated rheumatoid arthritis patients with random drug levels'. Rheumatology, . [Details]
Plant, D., A. Webster, N. Nair, J. Oliver, S. Smith, S. Eyre, K.L. Hyrich, A.G. Wilson, A.W. Morgan, J. Isaacs, J. Worthington, and A. Barton. (2016) 'Differential methylation as a biomarker of response to etanercept in patients with rheumatoid arthritis'. Arthritis and Rheumatism, 68 (6):1353-1360. [DOI] [Details]
Viatte S, Plant D, Han B, Fu B, Yarwood A, Thomson W, Symmons DPM, Worthington J, Young A, Hyrich KL, Morgan AW, Wilson AG, Isaacs JD, Raychaudhuri S, Barton A (2015) 'Association of HLA-DRB1 haplotypes with rheumatoid arthritis severity, mortality, and treatment response'. JAMA-Journal of the American Medical Association, 313 (16):1645-1656. Available Online [DOI] [Details]
Hsu, Y.H., Y. Liu, M.T. Hannan, W. Maixner, S.B. Smith, L. Diatchenko, Y.M. Golightly, H.B. Menz, V.B. Kraus, M. Doherty, A.G. Wilson, and J.M. Jordan. (2015) 'Genome-wide association meta-analyses to identify common genetic variants associated with hallux valgus in Caucasian and African Americans'. Journal of Medical Genetics, 52 (11):762-769. [DOI] [Details]
Smith SL; Eyre S; Yarwood A; Hyrich K; Morgan AW; Wilson AG; Isaacs J; Plant D; Barton A (2015) 'Investigating CD11c expression as a potential genomic biomarker of response to TNF inhibitor biologics in whole blood rheumatoid arthritis samples'. Arthritis Research and Therapy, 17 . [DOI] [Details]
Jani M, Chinoy H, Warren RB, Griffiths C E, Morgan AW, Wilson AG, Hyrich KL, Isaacs J, Plant D, Barton A (2015) 'Clinical utility of random anti-TNF drug level testing and measurement of anti-drug antibodies on long-term treatment response in rheumatoid arthritis'. Arthritis Rheumatology, 67 (8):2011-2019. Available Online [Details]
Montes A, Perez-Pampin E, Navarro-Sarabia F, Moreira V, de la Serna AR, Magallares B, Vasilopoulos Y, Sarafidou T, Fernández-Nebro A, del Carmen Ordóñez M, Narváez J, Cañete JD, Marquez A, Pascual-Salcedo D, Joven B, Carreira P, Moreno-Ramos MJ, Caliz R, Ferrer MA, Garcia-Portales R, Blanco FJ, Magro C, Raya E, Valor L, Alegre-Sancho JJ, Balsa A, Martin J, Plant D, Isaacs J, Morgan AW, Barton A, Wilson AG, (BRAGGSS), Gómez-Reino JJ, Gonzalez A (2015) 'Rheumatoid arthritis response to treatment across IgG1 allotype - anti-TNF incompatibility: a case-only study'. Arthritis Research & Therapy, 17 (1):63. Available Online [Details]
Bluett J, Morgan C, Thurston L, Plant D, Hyrich KL, Morgan AW, Wilson AG, Isaacs JD, Cordingley L, Barton A (2015) 'Impact of inadequate adherence on response to subcutaneously administered anti-tumour necrosis factor drugs: results from the Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate cohort'. Journal of Rheumatology, 54 (3):494-499. Available Online [Details]
Bluett J, et al. (2014) 'Association of a complement receptor 1 gene variant with baseline erythrocyte sedimentation rate levels in patients starting anti-TNF therapy in a UK rheumatoid arthritis cohort: results from the Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate cohort'. Pharmacogenomics, 14 (2):171-175. [Details]
Knevel R, de Rooy DP, Saxne T, Lindqvist E, Leijsma MK, Daha NA, Koeleman BP, Tsonaka R, Houwing-Duistermaat JJ, Schonkeren JJ, Toes RE, Huizinga TW, Brouwer E, Wilson AG, van der Helm-van Mil AH (2014) 'A genetic variant in osteoprotegerin is associated with progression of joint destruction in rheumatoid arthritis'. Arthritis Research & Therapy, 16 (3):R108. [Details]
Yarwood A, Viatte S, Plant D, Morgan AW, Isaacs J, Wilson AG, Hyrich K, Eyre S, Barton A. (2014) 'Testing the role of vitamin D in response to antitumour necrosis factor α therapy in a UK cohort: a Mendelian randomisation approach'. Annals of Rheumatic Diseases, 73 (5):938-940. [Details]
Bluett J, Morgan C, Thurston L, Plant D, Hyrich KL, Morgan AW, Wilson AG, Isaacs JD, Cordingley L, Barton A. (2014) 'Impact of inadequate adherence on response to subcutaneously administered anti-tumour necrosis factor drugs: results from the Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate cohort'. Rheumatology (Oxford, England), . [Details]
Cordingley L, Prajapati R, Plant D, Maskell D, Morgan C, Ali FR, Morgan AW, Wilson AG, Isaacs JD, Barton A. (2014) 'Impact of psychological factors on subjective disease activity assessments in patients with severe rheumatoid arthritis'. Arthritis Care and Research, 66 (6):861-868. [Details]
Plant D, Wilson AG, Barton A. (2014) 'Genetic and epigenetic predictors of responsiveness to treatment in RA'. Nature reviews. Rheumatology, 10 (6):329-337. [Details]
Mathews RJ, Robinson JI, Battellino M, Wong C, Taylor JC; Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate (BRAGGSS), Eyre S, Churchman SM, Wilson AG, Isaacs JD, Hyrich K, Barton A, Plant D, Savic S, Cook GP, Sarzi-Puttini P, Emery P, Barrett JH, Morgan AW, McDermott MF. (2014) 'Evidence of NLRP3-inflammasome activation in rheumatoid arthritis (RA); genetic variants within the NLRP3-inflammasome complex in relation to susceptibility to RA and response to anti-TNF treatment'. Annals of the Rheumatic Diseases, 73 (6):1202-1210. [Details]
Orozco G, Viatte S, Bowes J, Martin P, Wilson AG, Morgan AW, Steer S, Wordsworth P, Hocking LJ; Barton A, Worthington J, Eyre S. (2014) 'Novel Rheumatoid Arthritis susceptibility locus at 22q12 identified in an extended UK genome wide association study'. Arthritis Rheumatology, 66 (1):24-30. [Details]
Gay S. & Wilson AG. (2014) 'The emerging role of epigenetics in rheumatic diseases'. Rheumatology (Oxford, England), 53 (3):406-414. [Details]
de Rooy DP, Yeremenko NG, Wilson AG, Knevel R, Lindqvist E, Saxne T, Krabben A, Leijsma MK, Daha NA, Tsonaka S, Zhernakova A, Houwing-Duistermaat JJ, Huizinga TW, Toes RE, Baeten DL, Brouwer E, van der Helm-van Mil AH. (2013) 'Genetic studies on components of the Wnt signalling pathway and the severity of joint destruction in rheumatoid arthritis'. Annals of the Rheumatic Diseases, 72 (5):769-775. [Details]
McAllister K, Yarwood A, Bowes J, Orozco G, Viatte S, Diogo D, Hocking LJ, Steer S, Wordsworth P, Wilson AG, Morgan AW, Kremer JM, Pappas D, Gregersen P, Klareskog L, Plenge R, Barton A, Greenberg J, Worthington J, Eyre S. (2013) 'Identification of BACH2 and RAD51B as Rheumatoid Arthritis Susceptibility Loci in a Meta‐Analysis of Genome‐Wide Data'. Arthritis and Rheumatism, 65 (12):3058-3062. [Details]
Scott IC, Seegobin SD, Steer S, Tan R, Forabosco P, Hinks A, Eyre S, Morgan AW, Wilson AG, Hocking LJ, Wordsworth P, Barton A, Worthington J, Cope AP, Lewis CM. (2013) 'Predicting the risk of rheumatoid arthritis and its age of onset through modelling genetic risk variants with smoking'. PLoS Genetics, 9 (9):e:1003808. [Details]
A Krabben, AG Wilson, DPC de Rooy, A Zhernakova, E Brouwer, E Lindqvist, T Saxne, G Stoeken, JAB van Nies, R Knevel, TWJ Huizinga, B Koeleman, R Toes, PK Gregersen, AHM van der Helm-van Mil (2013) 'Genetic Variants in the IL-4 and IL-4 Receptor Genes in Association with the Severity of Joint Damage in Rheumatoid Arthritis: A Study in Seven Cohorts'. Arthritis and Rheumatism, 65 :3051-3057. [Details]
Hawtree, S and Muthana, M and Wilson, AG (2013) 'The role of histone deacetylases in rheumatoid arthritis fibroblast-like synoviocytes'. Biochemical Society Transactions, 41 (3):783-788. [Details]
Cui J, Stahl EA, Saevarsdottir S, Miceli C, Diogo D, Trynka G, Raj T, Mirkov MU, Canhao H, Ikari K, Terao C, Okada Y, Wedrén S, Askling J, Yamanaka H, Momohara S, Taniguchi A, Ohmura K, Matsuda F, Mimori T, Gupta N, Kuchroo M, Morgan AW, Isaacs JD, Wilson AG, Hyrich KL, Herenius M, Doorenspleet ME, Tak PP, Crusius JB, van der Horst-Bruinsma IE, Wolbink GJ, van Riel PL, van de Laar M, Guchelaar HJ, Shadick NA, Allaart CF, Huizinga TW, Toes RE, Kimberly RP, Bridges SL Jr, Criswell LA, Moreland LW, Fonseca JE, de Vries N, Stranger BE, De Jager PL, Raychaudhuri S, Weinblatt ME, Gregersen PK, Mariette X, Barton A, Padyukov L, Coenen MJ, Karlson EW, Plenge RM. (2013) 'Genome-Wide Association Study and Gene Expression Analysis Identifies CD84 as a Predictor of Response to Etanercept Therapy in Rheumatoid Arthritis'. PLoS Genetics, 9 (3):e1003394. [Details]
Knevel R, Krabben A, Wilson AG, Brouwer E, Leijsma MK, Lindqvist E, de Rooy DP, Daha NA, van der Linden MP, Tsonaka S, Zhernakova A, Westra HJ, Franke L, Houwing-Duistermaat JJ, Toes RE, Huizinga TW, Saxne T, van der Helm-van Mil AH. (2013) 'A genetic variant in granzyme B is associated with progression of joint destruction in rheumatoid arthritis'. Arthritis and Rheumatism, 65 (3):582-589. [Details]
McAllister K, Yarwood A, Bowes J, Orozco G, Viatte S, Diogo D, Hocking LJ, Steer S, Wordsworth P, Wilson AG, Morgan AW; UK Rheumatoid Arthritis Genetics Consortium, Rheumatoid Arthritis Consortium International, Kremer JM, Pappas D, Gregersen P, Klareskog L, Plenge R, Barton A, Greenberg J, Worthington J, Eyre S. (2013) 'Meta-analysis identifies BACH2 and RAD51B as rheumatoid arthritis susceptibility loci'. Arthritis and Rheumatism, 65 (12):3058-3062. [Details]
Taylor LH, Twigg S, Worthington J, Emery P, Morgan AW, Wilson AG, Teare MD. (2013) 'Metaanalysis of the Association of Smoking and PTPN22 R620W Genotype on Autoantibody Status and Radiological Erosions in Rheumatoid Arthritis'. Journal of Rheumatology, 40 (7):1048-1053. [Details]
Teare MD, Knevel R, Morgan MD, Kleszcz A, Emery P, Moore DJ, Conaghan P, Huizinga TW, Morgan AW, van der Helm-van Mil AH, Wilson AG. (2013) 'Allele-Dose Association of the C5orf30 rs26232 Variant With Joint Damage in Rheumatoid Arthritis'. Arthritis and Rheumatism, 65 (10):2555-2561. [Details]
Sarwar, N., A.S. Butterworth, D.F. Freitag, J. Gregson, P. Willeit, D.N. Gorman, P. Gao, D. Saleheen, A. Rendon, C.P. Nelson, P.S. Braund, A.S. Hall, D.I. Chasman, A. Tybjaerg-Hansen, J.C. Chambers, E.J. Benjamin, P.W. Franks, R. Clarke, A.A. Wilde, M.D. Trip, M. Steri, J.C. Witteman, L. Qi, C.E. van der Schoot, U. de Faire, J. Erdmann, H.M. Stringham, W. Koenig, D.J. Rader, D. Melzer, D. Reich, B.M. Psaty, M.E. Kleber, D.B. Panagiotakos, J. Willeit, P. Wennberg, M. Woodward, S. Adamovic, E.B. Rimm, T.W. Meade, R.F. Gillum, J.A. Shaffer, A. Hofman, A. Onat, J. Sundstrom, S. Wassertheil-Smoller, D. Mellstrom, J. Gallacher, M. Cushman, R.P. Tracy, J. Kauhanen, M. Karlsson, J.T. Salonen, L. Wilhelmsen, P. Amouyel, B. Cantin, L.G. Best, Y. Ben-Shlomo, J.E. Manson, G. Davey-Smith, P.I. de Bakker, C.J. O'Donnell, J.F. Wilson, A.G. Wilson, T.L. Assimes, J.O. Jansson, C. Ohlsson, A. Tivesten, O. Ljunggren, M.P. Reilly, A. Hamsten, E. Ingelsson, F. Cambien, J. Hung, G.N. Thomas, M. Boehnke, H. Schunkert, F.W. Asselbergs, J.J. Kastelein, V. Gudnason, V. Salomaa, T.B. Harris, J.S. Kooner, K.H. Allin, B.G. Nordestgaard, J.C. Hopewell, A.H. Goodall, P.M. Ridker, H. Holm, H. Watkins, W.H. Ouwehand, N.J. Samani, S. Kaptoge, E. Di Angelantonio, O. Harari, and J. Danesh (2012) 'Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies'. The Lancet, 379 ((9822)):1205-1213. [Details]
Mackie SL, Taylor JC, Twigg S, Martin SG, Steer S, Worthington J, Barton A, Wilson AG, Hocking L, Young A, Emery P, Barrett JH, Morgan AW. (2012) 'Relationship between area-level socio-economic deprivation and autoantibody status in patients with rheumatoid arthritis: multicentre cross-sectional study'. Annals of the Rheumatic Diseases, 71 (10):1640-1645. [Details]
Zaitlen N, Lindström S, Pasaniuc B, Cornelis M, Genovese G, Pollack S, Barton A, Bickeböller H, Bowden DW, Eyre S, Freedman BI, Friedman DJ, Field JK, Groop L, Haugen A, Heinrich J, Henderson BE, Hicks PJ, Hocking LJ, Kolonel LN, Landi MT, Langefeld CD, Le Marchand L, Meister M, Morgan AW, Raji OY, Risch A, Rosenberger A, Scherf D, Steer S, Walshaw M, Waters KM, Wilson AG, Wordsworth P, Zienolddiny S, Tchetgen ET, Haiman C, Hunter DJ, Plenge RM, Worthington J, Christiani DC, Schaumberg DA, Chasman DI, Altshuler D, Voight B, Kraft P, Patterson N, Price AL. (2012) 'Informed conditioning on clinical covariates increases power in case-control association studies'. PLoS Genetics, 8 (11):e1003032. [Details]
Maxwell JR, Gowers IR, Kuet KP, Barton A, Worthington J, Wilson AG. (2012) 'Expression of the autoimmunity associated TNFAIP3 is increased in rheumatoid arthritis but does not differ according to genotype at 6q23'. Rheumatology (Oxford, England), 51 (8):1514-1515. [Details]
P.S. Grabowski, M. Muthana, A.G. Wilson (2012) 'Acid sensing protein genes are expressed in human rheumatoid-derived synoviocytes'. Bone, 50 (1):S191. [Details]
Knevel R, de Rooy DP, Gregersen PK, Lindqvist E, Wilson AG, Gröndal G, Zhernakova A, van Nies JA, Toes RE, Tsonaka R, Houwing-Duistermaat JJ, Steinsson K, Huizinga TW, Saxne T, van der Helm-van Mil AH. (2012) 'Studying associations between variants in TRAF1-C5 and TNFAIP3-OLIG3 and the progression of joint destruction in rheumatoid arthritis in multiple cohorts'. Annals of the Rheumatic Diseases, 71 (10):1753-1755. [Details]
Plant D, Prajapati R, Hyrich KL, Morgan AW, Wilson AG, Isaacs JD, Barton A. (2012) 'Replication of association of the PTPRC gene with response to anti--tumor necrosis factor therapy in a large UK cohort'. Arthritis and Rheumatism, 64 (3):665-670. [Details]
Robinson JI, Carr IM, Cooper DL, Rashid LH, Martin SG, Emery P, Isaacs JD, Barton A, Wilson AG, Barrett JH, Morgan AW. (2012) 'Confirmation of association of FCGR3B but not FCGR3A copy number with susceptibility to autoantibody positive rheumatoid arthritis'. Human Mutation, 33 (4):741-749. [Details]
Knevel R, Krabben A, Brouwer E, Posthumus MD, Wilson AG, Lindqvist E, Saxne T, de Rooy D, Daha N, van der Linden MP, Stoeken G, van Toorn L, Koeleman B, Tsonaka R, Zhernakoza A, Houwing-Duistermaat JJ, Toes R, Huizinga TW, van der Helm-van Mil A. (2012) 'Genetic variants in IL15 associate with progression of joint destruction in rheumatoid arthritis: a multicohort study'. Annals of the Rheumatic Diseases, 71 (10):1651-1657. [Details]
James R Maxwell, Darren Plant, Anne Barton, Kimme L Hyrich, Ann W Morgan, John Isaacs, Anthony G Wilson (2012) 'Response to Etanercept, but Not Infliximab or Adalimumab, Is Inversely Associated with Body Mass Index'. Arthritis and Rheumatism, 64 (10). [Details]
James R Maxwell, Lyndsey H Taylor, Richardo A Pachecho, Neil Lawrence, Gordon W Duff, M Dawn Teare, Anthony G Wilson (2012) 'Inverse Relation Between the tumor Necrosis Factor Promoter Methylation and Trascript Leveles in Leukocytes From Patients with Rheumatoid Arthritis'. Arthritis and Rheumatism, 64 (10). [Details]
Plant, D., I. Ibrahim, M. Lunt, S. Eyre, E. Flynn, K.L. Hyrich, A.W. Morgan, A.G. Wilson, J.D. Isaacs, and A. Barton (2012) 'Correlation of C-reactive protein haplotypes with serum C-reactive protein level and response to anti-tumor necrosis factor therapy in UK rheumatoid arthritis patients: results from the Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate cohort'. Arthritis Research & Therapy, 14 (5):R214. [Details]
Maxwell, J.R., I. Marinou, K.P. Kuet, G. Orozco, D.J. Moore, A. Barton, J. Worthington, and A.G. Wilson. (2012) 'Rheumatoid Arthritis-associated Polymorphisms at 6q23 Are Associated with Radiological Damage in Autoantibody-positive RA'. Journal of Rheumatology, 39 (9):1781-1785. [Details]
Zaitlen, N., S. Lindström, B. Pasaniuc, M. Cornelis, G. Genovese, A. Barton, D.W. Bowden, S. Eyre, B.I. Freedman, D.J. Friedman, L. Groop, B.E. Henderson, P.J. Hicks, L.J Hocking, L.N. Kolonel, C.D. Langefeld, L. Le Marchand, A.W. Morgan, S. Steer, K.M. Waters, A.G. Wilson, P. Wordsworth, C. Haiman, D. Hunter, R. Plenge, J. Worthington, D.A. Schaumberg, D.I. Chasman, D. Altshuler, B. Voight, P. Kraft, N. Patterson, and A. L. Price (2012) 'Liability threshold modeling of covariates increases power in case-control association studies'. PLoS Genetics, 8 (11):e1003032. [Details]
Rita Prajapati, Darren Plant, Deborah Maskell, Ann W Morgan, Anthony G Wilson, John Isaacs, Lis Cordingley, Anne Barton (2011) 'Investigation of the relationship between patient-centered factors and baseline disease activity (DAS28) in rheumatoid arthritis (RA)'. Arthritis and Rheumatism, 63 (10). [Details]
Gowers IR, Walters K, Kiss-Toth E, Read RC, Duff GW, Wilson AG. (2011) 'Age-related loss of CpG methylation in the tumour necrosis factor promoter'. Cytokine, 56 (3):792-797. [Details]
Morgan AW, Thomson W, Martin SG; Yorkshire Early Arthritis Register Consortium, Carter AM; UK Rheumatoid Arthritis Genetics Consortium, Erlich HA, Barton A, Hocking L, Reid DM, Harrison P, Wordsworth P, Steer S, Worthington J, Emery P, Wilson AG, Barrett JH. (2011) 'Reevaluation of the interaction between HLA--DRB1 shared epitope alleles, PTPN22, and smoking in determining susceptibility to autoantibody-positive and autoantibody-negative rheumatoid arthritis in a large UK Caucasian population'. Arthritis and Rheumatism, 60 :2565-2576. [Details]
McClure A, Lunt M, Eyre S, Ke X, Thomson W, Hinks A, Bowes J, Gibbons L, Plant D, Wilson AG, Marinou I, Morgan AW, Emery P; BIRAC consortium, Steer S, Hocking LJ, Reid DM, Wordsworth P, Harrison P, Worthington J, Barton A. (2011) 'Investigating the viability of genetic screening/testing for RA susceptibility using combinations of five confirmed risk loci'. Rheumatology (Oxford, England), 50 (6):1178-1178. [Details]
Orozco G, Eyre S, Hinks A, Bowes J, Morgan AW, Wilson AG, Wordsworth P, Steer S, Hocking L; UKRAG consortium, Thomson W, Worthington J, Barton A. (2011) 'Study of the common genetic background for rheumatoid arthritis and systemic lupus erythematosus'. Annals of the Rheumatic Diseases, 70 (3):463-468. [Details]
Plant D, Bowes J, Potter C, Hyrich KL, Morgan AW, Wilson AG, Isaacs JD; Wellcome Trust Case Control Consortium; British Society for Rheumatology Biologics Register, Barton A. (2011) 'Genome-wide association study of genetic predictors of anti--tumor necrosis factor treatment efficacy in rheumatoid arthritis identifies associations with polymorphisms at seven loci'. Arthritis and Rheumatism, 63 (3):645-653. [Details]
Mewar D, Wilson AG. (2011) 'Treatment of rheumatoid arthritis with tumour necrosis factor inhibitors'. British Journal of Pharmacology, 162 (4):785-791. [Details]
Coulthard LR, Taylor JC, Eyre S; Biologics in Rheumatoid Arthritis Genetics and Genomics, Robinson JI, Wilson AG, Isaacs JD, Hyrich K, Emery P, Barton A, Barrett JH, Morgan AW, McDermott MF. (2011) 'Genetic variants within the MAP kinase signalling network and anti-TNF treatment response in rheumatoid arthritis patients'. Annals of the Rheumatic Diseases, 70 (1):98-103. [Details]
Mackie SL, Taylor JC, Martin SG; YEAR Consortium; UKRAG Consortium, Wordsworth P, Steer S, Wilson AG, Worthington J, Emery P, Barrett JH, Morgan AW. (2011) 'A spectrum of susceptibility to rheumatoid arthritis within HLA-DRB1: stratification by autoantibody status in a large UK population'. Genes and Immunity, 13 (2):120-128. [Details]
M. S. Yau, L. Yerges-Armstrong, M. Doherty, M. Hochberg, J. M. Jordan, V. B. Kraus, B. Mitchell, A. G. Wilson, (2011) 'Heritability and Linkage of Radiographic Progression of Hip and Knee Osteoarthritis: Results From the Longitudinal Component of the Genetics of Generalized Osteoarthritis Study'. Arthritis and Rheumatism, 63 (10). [Details]
Marinou, I., K. Walters, J. Winfield, D.E. Bax, and A.G. Wilson. (2010) 'A gain of function polymorphism in the interleukin 6 receptor influences RA susceptibility'. Annals of the Rheumatic Diseases, 69 (6):1191-1194. [Details]
Eyre S, Flynn E, Martin P, Hinks A, Wilson AG, Morgan AW, Emery P, Steer S, Hocking LJ, Reid DM, Harrison P, Wordsworth P, Thomson W, Worthington J, Barton A. (2010) 'No evidence for association of the KLF12 gene with rheumatoid arthritis in a large UK cohort'. Annals of the Rheumatic Diseases, 69 (7):1407-1408. [Details]
Potter C, Gibbons LJ, Bowes JD, Cordell HJ, Hyrich K, Isaacs JD, Morgan AW, Wilson AG, Barton A; (2010) 'Polymorphisms spanning the TNFR2 and TACE genes do not contribute towards variable anti-TNF treatment response'. Pharmacogenomics, 20 (5):338-341. [Details]
Emery, P and Orozco, G and Hinks, A and Eyre, S and Ke, X and Gibbons, LJ and Bowes, J and Flynn, E and Martin, P and Wilson, AG and others (2010) 'CORRIGENDUM: COMBINED EFFECTS OF THREE INDEPENDENT SNPS GREATLY INCREASE THE RISK ESTIMATE FOR RA AT 6Q23'. Human Molecular Genetics, 19 (22). [Details]
Emery, P and Barton, A and Eyre, S and Ke, X and Hinks, A and Bowes, J and Flynn, E and Martin, P and Wilson, AG and Morgan, AW and others (2010) 'Identification of AF4/FMR2 family, member 3 (AFF3) as a novel rheumatoid arthritis susceptibility locus and confirmation of two further pan-autoimmune susceptibility genes'. Human Molecular Genetics, 18 (13):2518-2522. [Details]
Burr, Marian L and Naseem, Haris and Hinks, Anne and Eyre, Steve and Gibbons, Laura J and Bowes, John and Wilson, Anthony G and Maxwell, James and Morgan, Ann W and Emery, Paul and others (2010) 'PADI4 genotype is not associated with rheumatoid arthritis in a large UK Caucasian population'. Annals of the rheumatic diseases, 69 (4):666-670. [Details]
Craddock, Nick and Hurles, Matthew E and Cardin, Niall and Pearson, Richard D and Plagnol, Vincent and Robson, Samuel and Vukcevic, Damjan and Barnes, Chris and Conrad, Donald F and Giannoulatou, Eleni and others (2010) 'Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls'. Nature, 464 (7289):713-720. [Details]
Stahl, Eli A and Raychaudhuri, Soumya and Remmers, Elaine F and Xie, Gang and Eyre, Stephen and Thomson, Brian P and Li, Yonghong and Kurreeman, Fina AS and Zhernakova, Alexandra and Hinks, Anne and others (2010) 'Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci'. Nature genetics, 42 (6):508-514. [Details]
Orozco G, Eyre S, Hinks A, Ke X, Wilson AG, Bax DE, Morgan AW, Emery P, Steer S, Hocking L, Reid DM, Wordsworth P, Harrison P, Thomson W, Barton A, Worthington J. (2010) 'Association of CD40 with rheumatoid arthritis confirmed in a large UK case-control study'. Annals of the Rheumatic Diseases, 69 (5):813-816. [Details]
Maxwell JR, Gowers IR, Moore DJ, Wilson AG. (2010) 'Alcohol consumption is inversely associated with risk and severity of rheumatoid arthritis'. Rheumatology (Oxford, England), 49 (11):2140-2146. [Details]
Cui J, Saevarsdottir S, Thomson B, Padyukov L, van der Helm-van Mil AH, Nititham J, Hughes LB, de Vries N, Raychaudhuri S, Alfredsson L, Askling J, Wedrén S, Ding B, Guiducci C, Wolbink GJ, Crusius JB, van der Horst-Bruinsma IE, Herenius M, Weinblatt ME, Shadick NA, Worthington J, Batliwalla F, Kern M, Morgan AW, Wilson AG, Isaacs JD, Hyrich K, Seldin MF, Moreland LW, Behrens TW, Allaart CF, Criswell LA, Huizinga TW, Tak PP, Bridges SL Jr, Toes RE, Barton A, Klareskog L, Gregersen PK, Karlson EW, Plenge RM. (2010) 'Rheumatoid arthritis risk allele PTPRC is also associated with response to anti-tumor necrosis factor alpha therapy'. Arthritis and Rheumatism, 62 (7):1849-1861. [Details]
Mohanty ST, Kottam L, Gambardella A, Nicklin MJ, Coulton L, Hughes D, Wilson AG, Croucher PI, Bellantuono I. (2010) 'Alterations in the self-renewal and differentiation ability of bone marrow mesenchymal stem cells in a mouse model of rheumatoid arthritis'. Arthritis Research & Therapy, 12 (4):R149. [Details]
Eyre S, Hinks A, Flynn E, Martin P, Wilson AG, Maxwell JR, Morgan AW, Emery P, Steer S, Hocking LJ, Reid DM, Harrison P, Wordsworth P, Thomson W, Worthington J, Barton A. (2010) 'Confirmation of association of the REL locus with rheumatoid arthritis susceptibility in the UK population'. Annals of the Rheumatic Diseases, 69 (8):1572-1573. [Details]
Eyre S, Hinks A, Bowes J, Flynn E, Martin P, Wilson AG, Morgan AW, Emery P, Steer S, Hocking LJ, Reid DM, Harrison P, Wordsworth P, Thomson W, Worthington J, Barton A. (2010) 'Overlapping genetic susceptibility variants between three autoimmune disorders: rheumatoid arthritis, type 1 diabetes and coeliac disease'. Arthritis Research & Therapy, 12 (5):R175. [Details]
Tan RJ, Gibbons LJ, Potter C, Hyrich KL, Morgan AW, Wilson AG, Isaacs JD, Barton A. (2010) 'Investigation of rheumatoid arthritis susceptibility genes identifies association of AFF3 and CD226 variants with response to anti-tumour necrosis factor treatment'. Annals of the Rheumatic Diseases, 69 (6):1029-1035. [Details]
Potter C, Cordell HJ, Barton A, Daly AK, Hyrich KL, Mann DA, Morgan AW, Wilson AG, Isaacs JD. (2010) 'Association between anti-tumour necrosis factor treatment response and genetic variants within the TLR and NF$\kappa$B signalling pathways'. Annals of the Rheumatic Diseases, 69 (7):1315-1320. [Details]
Hassan B, Maxwell JR, Hyrich KL; Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate, Barton A, Worthington J, Isaacs JD, Morgan AW, Wilson AG. (2010) 'Genotype at the sIL-6R A358C polymorphism does not influence response to anti-TNF therapy in patients with rheumatoid arthritis'. Rheumatology (Oxford, England), 49 (1):43-47. [Details]
Robinson JI, Barrett JH, Taylor JC; YEAR Consortium, Naven M, Corscadden D; BRAGGSS, Barton A, Wilson AG, Emery P, Isaacs JD, Morgan AW. (2010) 'Dissection of the FCGR3A association with RA: increased association in men and with autoantibody positive disease'. Annals of the Rheumatic Diseases, 69 (6):1054-1057. [Details]
Marinou I, Maxwell JR, Wilson AG (2010) 'Genetic influences modulating the radiological severity of rheumatoid arthritis'. Annals of the Rheumatic Diseases, 69 (3):476-482. [Details]
Raychaudhuri S, Thomson BP, Remmers EF, Eyre S, Hinks A, Guiducci C, Catanese JJ, Xie G, Stahl EA, Chen R, Alfredsson L, Amos CI, Ardlie KG; BIRAC Consortium, Barton A, Bowes J, Burtt NP, Chang M, Coblyn J, Costenbader KH, Criswell LA, Crusius JB, Cui J, De Jager PL, Ding B, Emery P, Flynn E,Harrison P, Hocking LJ, Huizinga TW, Kastner DL, Ke X, Kurreeman FA, Lee AT, Liu X, Li Y, Martin P, Morgan AW, Padyukov L, Reid DM, Seielstad M, Seldin MF,Shadick NA, Steer S, Tak PP, Thomson W, van der Helm-van Mil AH, van der Horst-Bruinsma IE, Weinblatt ME, Wilson AG, Wolbink GJ, Wordsworth P; YEAR Consortium, Altshuler D, Karlson EW, Toes RE, de Vries N, Begovich AB, Siminovitch KA, Worthington J, Klareskog L, Gregersen PK, Daly MJ, Plenge RM (2009) 'Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk'. Nature Genetics, 41 (12):1313-1318. [Details]
Maxwell JR, Gowers IR, Wilson AG. (2009) 'Complex genetic association of 6q23 with autoimmune rheumatic conditions'. Arthritis Research & Therapy, 11 (2):107. [Details]
Vignal, Charlotte and Bansal, Aruna T and Balding, David J and Binks, Michael H and Dickson, Marion C and Montgomery, Doug S and Wilson, Anthony G (2009) 'Reply'. Arthritis \& Rheumatism, 60 (7):2207-2208. [Details]
Orozco G, Hinks A, Eyre S, Ke X, Gibbons LJ, Bowes J, Flynn E, Martin P, Wilson AG, Bax DE, Morgan AW, Emery P, Steer S, Hocking L, Reid DM, Wordsworth P, Harrison P, Thomson W, Barton A, Worthington J. (2009) 'Combined effects of three independent SNPs greatly increase the risk estimate for RA at 6q23'. Human Molecular Genetics, 18 (14):2693-2699. [Details]
Potter C, Hyrich KL, Tracey A, Lunt M, Plant D, Symmons DP, Thomson W, Worthington J, Emery P, Morgan AW, Wilson AG, Isaacs J, Barton A (2009) 'Association of rheumatoid factor and anti-cyclic citrullinated peptide positivity, but not carriage of shared epitope or PTPN22 susceptibility variants, with anti-tumour necrosis factor response in rheumatoid arthritis'. Annals of the Rheumatic Diseases, 68 (1):69-74. [Details]
Vignal C, Bansal AT, Balding DJ, Binks MH, Dickson MC, Montgomery DS, Wilson AG. (2009) 'Genetic association of the major histocompatibility complex with rheumatoid arthritis implicates two non-DRB1 loci'. Arthritis and Rheumatism, 60 (1):53-62. [Details]
Morgan AW, Thomson W, Martin SG; Yorkshire Early Arthritis Register Consortium, Carter AM, Erlich HA, Barton A, Hocking L, Reid DM, Harrison P, Wordsworth P, Steer S, Worthington J, Emery P, Wilson AG, Barrett JH. (2009) 'Reevaluation of the interaction between HLA--DRB1 shared epitope alleles, PTPN22, and smoking in determining susceptibility to autoantibody-positive and autoantibody-negative rheumatoid arthritis in a large UK Caucasian population'. Arthritis and Rheumatism, 60 (9):2565-2576. [Details]
Barton A, Eyre S, Ke X, Hinks A, Bowes J, Flynn E, Martin P, Wilson AG, Morgan AW, Emery P, Steer S, Hocking LJ, Reid DM, Harrison P, Wordsworth P, Thomson W, Worthington J. (2009) 'Identification of AF4/FMR2 family, member 3 (AFF3) as a novel rheumatoid arthritis susceptibility locus and confirmation of two further pan-autoimmune susceptibility genes'. Human Molecular Genetics, 18 (13):2518-2522. [Details]
Read RC, Teare DM, Pridmore AC, Naylor SC, Timms JM, Kaczmarski EB, Borrow R, Wilson AG. (2009) 'The tumor necrosis factor polymorphism TNF (-308) is associated with susceptibility to meningococcal sepsis, but not with lethality'. Critical Care Medicine, 37 (4):1237-1243. [Details]
Bowes JD, Potter C, Gibbons LJ, Hyrich K, Plant D, Morgan AW, Wilson AG, Isaacs JD, Worthington J, Barton A (2009) 'Investigation of genetic variants within candidate genes of the TNFRSF1B signalling pathway on the response to anti-TNF agents in a UK cohort of rheumatoid arthritis patients'. Pharmacogenomics, 19 (4):319-323. [Details]
Marinou I, Walters K, Dickson MC, Binks MH, Bax DE, Wilson AG. (2009) 'Evidence of epistasis between interleukin 1 and selenoprotein-S with susceptibility to rheumatoid arthritis'. Annals of the Rheumatic Diseases, 68 (9):1494-1497. [Details]
McClure A, Lunt M, Eyre S, Ke X, Thomson W, Hinks A, Bowes J, Gibbons L, Plant D, Wilson AG, Marinou I, Morgan AW, Emery P, Steer S, Hocking LJ, Reid DM, Wordsworth P, Harrison P, Worthington J, Barton A. (2009) 'Investigating the viability of genetic screening/testing for RA susceptibility using combinations of five confirmed risk loci'. Rheumatology (Oxford, England), 48 (11):1369-1374. [Details]
Plant D, Barton A, Thomson W, Ke X, Eyre S, Hinks A, Bowes J, Gibbons LJ, Wilson AG, Marinou I, Morgan AW, Steer S, Hocking LJ, Reid DM, Wordsworth P, Harrison P, Worthington J. (2009) 'A re-evaluation of three putative functional single nucleotide polymorphisms in rheumatoid arthritis'. Annals of the Rheumatic Diseases, 68 (8):1373-1375. [Details]
Marinou I, Till SH, Moore DJ, Wilson AG. (2008) 'Lack of association or interactions between the IL-4, IL-4Ralpha and IL-13 genes, and rheumatoid arthritis'. Arthritis Research & Therapy, 10 (4):R80. [Details]
Cantaert, Tineke and Stone, Millicent A and ter Borg, Mari\"ette and Mogg, Rebecca and De Vries, Niek and Wilson, Anthony G and Tak, Paul-Peter and Baeten, Dominique (2008) 'A functional polymorphism of TIR-domain-containing adaptor protein is not associated with axial spondyloarthritis'. Annals of the rheumatic diseases, 67 (5):720-722. [Details]
Cantaert T, Stone MA, ter Borg M, Mogg R, De Vries N, Wilson AG, Tak PP, Baeten D. (2008) 'A Functional Variant of TIR-domain-containing Adaptor Protein (TIRAP) is Not Associated with Spondyloarthritis'. Annals of the Rheumatic Diseases, 67 (5):720-722. [Details]
Gordon, A and Southam, L and Loughlin, J and White, G and Wilson, AG and Stockley, I and Hamer, AJ and Eastell, R and Wilkinson, JM (2008) 'VARIATION WITHIN THE GENE ENCODING SFRP-3 AFFECTS BONE PHENOTYPE BEFORE AND AFTER TOTAL HIP ARTHROPLASTY'. Journal of Bone Joint Surgery, 90 (SUPP III):533-533. [Details]
Maxwell JR, Potter C, Hyrich KL, Barton A, Worthington J, Isaacs JD, Morgan AW, Wilson AG. (2008) 'Association of the tumour necrosis factor-308 variant with differential response to anti-TNF agents in the treatment of rheumatoid arthritis'. Human Molecular Genetics, 17 (22):3532-3538. [Details]
Wilson AG. (2008) 'Epigenetic regulation of gene expression in the inflammatory response and relevance to common diseases'. Journal of clinical periodontology, 79 (8S):1514-1519. [Details]
Nile CJ, Read RC, Akil M, Duff GW, Wilson AG (2008) 'Methylation status of a single CpG site in the IL6 promoter is related to IL6 messenger RNA levels and rheumatoid arthritis'. Arthritis and Rheumatism, 58 (9):2686-2693. [Details]
Barton A, Thomson W, Ke X, Eyre S, Hinks A, Bowes J, Gibbons L, Plant D; Wellcome Trust Case Control Consortium, Wilson AG, Marinou I, Morgan A, Emery P; YEAR consortium, Steer S, Hocking L, Reid DM, Wordsworth P, Harrison P, Worthington J. (2008) 'Re-evaluation of putative rheumatoid arthritis susceptibility genes in the post-genome wide association study era and hypothesis of a key pathway underlying susceptibility'. Human Molecular Genetics, 17 (15):2274-2279. [Details]
Barton A, Thomson W, Ke X, Eyre S, Hinks A, Bowes J, Plant D, Gibbons LJ, Wilson AG, Bax DE, Morgan AW, Emery P, Steer S, Hocking L, Reid DM, Wordsworth P, Harrison P, Worthington J. (2008) 'Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13'. Nature Genetics, 40 (10):1156-1159. [Details]
Rioja I, Hughes FJ, Sharp CH, Warnock LC, Montgomery DS, Akil M, Wilson AG, Binks MH, Dickson MC. (2008) 'Potential novel biomarkers of disease activity in rheumatoid arthritis patients: CXCL13, CCL23, transforming growth factor $\alpha$, tumor necrosis factor receptor superfamily member 9, and macrophage colony-stimulating factor'. Arthritis and Rheumatism, 58 (8):2257-2267. [Details]
Atif U, Philip A, Aponte J, Woldu EM, Brady S, Kraus VB, Jordan JM, Doherty M, Wilson AG, Moskowitz RW, Hochberg M, Loeser R, Renner JB, Chiano M. (2008) 'Absence of association of asporin polymorphisms and osteoarthritis susceptibility in US Caucasians'. Osteoarthritis and Cartilage, 16 (10):1174-1177. [Details]
Mewar D, Marinou I, Coote AL, Moore DJ, Akil M, Smillie D, Dickson MC, Binks MH, Montgomery DS, Wilson AG. (2008) 'Association between radiographic severity of rheumatoid arthritis and shared epitope alleles: differing mechanisms of susceptibility and protection'. Annals of the Rheumatic Diseases, 67 (7):980-983. [Details]
Sheedy FJ, Marinou I, O'Neill LA, Wilson AG. (2008) 'The Mal/TIRAP S180L and TLR4 G299D polymorphisms are not associated with susceptibility to, or severity of, rheumatoid arthritis'. Annals of the Rheumatic Diseases, 67 (9):1328-1331. [Details]
Potter C, Hyrich KL, Tracey A, Lunt M, Plant D, Symmons DP, Thomson W, Worthington J, Emery P, Morgan AW, Wilson AG, Isaacs J, Barton A. (2008) 'Association of RF and anti-CCP positivity, but not carriage of shared epitope or PTPN22 susceptibility variants, with anti-TNF response in RA'. Annals of the Rheumatic Diseases, 68 (1):69-74. [Details]
Marinou I, Healy J, Mewar D, Moore DJ, Dickson MC, Binks MH, Montgomery DS, Walters K, Wilson AG. (2007) 'Association of interleukin-6 and interleukin-10 genotypes with radiographic damage in rheumatoid arthritis is dependent on autoantibody status'. Arthritis and Rheumatism, 56 :2549-2556. [Details]
Sung HY, Guan H, Czibula A, King AR, Eder K, Heath E, Suvarna SK, Dower SK, Wilson AG, Francis SE, Crossman DC, Kiss-Toth E. (2007) 'Human tribbles-1 controls proliferation and chemotaxis of smooth muscle cells via MAPK signaling pathways'. Journal of Biological Chemistry, 282 (25):18379-18387. [Details]
Thomson W, Barton A, Ke X, Eyre S, Hinks A, Bowes J, Donn R, Symmons D, Hider S, Bruce IN, Wilson AG, Marinou I, Morgan A, Emery P; YEAR Consortium, Carter A, Steer S, Hocking L, Reid DM, Wordsworth P, Harrison P, Strachan D, Worthington J. (2007) 'Rheumatoid arthritis association at 6q23'. Nature Genetics, 39 (12):1431-1433. [Details]
Kraus VB, Jordan JM, Doherty M, Wilson AG, Moskowitz R, Hochberg M, Loeser R, Hooper M, Renner JB, Crane MM, Hastie P, Sundseth S, Atif U. (2007) 'The Genetics of Generalized Osteoarthritis (GOGO) study: study design and evaluation of osteoarthritis phenotypes'. Osteoarthritis and Cartilage, 15 (2):120-127. [Details]
Marinou I, Montgomery DS, Dickson MC, Binks MH, Moore DJ, Bax DE, Wilson AG. (2007) 'The interferon induced with helicase domain 1 A946T polymorphism is not associated with rheumatoid arthritis'. Arthritis Research & Therapy, 9 (2):R40. [Details]
Gordon A, Southam L, Loughlin J, Wilson AG, Stockley I, Hamer AJ, Eastell R, Wilkinson JM. (2007) 'Variation in the secreted frizzled-related protein-3 gene and risk of Osteolysis and heterotopic ossification after total hip arthroplasty'. journal of orthopedic research, 25 (12):1665-1670. [Details]
Greetham D, Ellis CD, Mewar D, Fearon U, an Ultaigh SN, Veale DJ, Guesdon F, Wilson AG. (2007) 'Functional characterization of NF-kappaB inhibitor-like protein 1 (NFkappaBIL1), a candidate susceptibility gene for rheumatoid arthritis'. Human Molecular Genetics, 16 (24):3027-3036. [Details]
Mewar D, Marinou I, Lee ME, Timms JM, Kilding R, Teare MD, Read RC, Wilson AG. (2006) 'Haplotype-specific gene expression profiles in a telomeric major histocompatibility complex gene cluster and susceptibility to autoimmune diseases'. Genes and Immunity, 7 (8):625-631. [Details]
Maxwell JR, Wilson AG. (2006) 'Cytokine pharmacogenetics'. Cytokine, 33 (6):362-366. [Details]
Mewar D, Coote A, Moore DJ, Marinou I, Keyworth J, Dickson MC, Montgomery DS, Binks MH, Wilson AG. (2006) 'Independent associations of anti-cyclic citrullinated peptide antibodies and rheumatoid factor with radiographic severity of rheumatoid arthritis'. Arthritis Research & Therapy, 8 (4):R128. [Details]
Menezo V, Bond SK, Towler HM, Kuo NW, Baharlo B, Wilson AG, Lightman S. (2006) 'Cytokine gene polymorphisms involved in chronicity and complications of anterior uveitis'. Cytokine, 35 (3):200-206. [Details]
Balasubramanian SP, Azmy IA, Higham SE, Wilson AG, Cross SS, Cox A, Brown NJ, Reed MW. (2006) 'Interleukin gene polymorphisms and breast cancer: a case control study and systematic literature review'. BMC Cancer, 14 (6):188. [Details]
Mewar D, Moore DJ, Young-Min S, Bertolaccini ML, Khamashta MA, Watson PF, Wilson AG. (2005) 'Antiferritin antibodies discovered by phage display expression cloning are associated with radiographic damage in rheumatoid arthritis'. Arthritis and Rheumatism, 52 (12):3868-3872. [Details]
Minton EJ, Smillie D, Smith P, Shipley S, McKendrick MW, Gleeson DC, Underwood JC, Cannings C, Wilson AG (2005) 'Clearance of hepatitis C virus is not associated with single nucleotide polymorphisms in the IL-1,-6, or-10 genes'. Human immunology, 66 (2):127-132. [Details]
Kilding R, Wilson AG. (2005) 'Mapping of a novel susceptibility gene for rheumatoid arthritis in the telomeric MHC region'. Cytokine, 32 (2):71-75. [Details]
Azmy IA, Balasubramanian SP, Wilson AG, Stephenson TJ, Cox A, Brown NJ, Reed MW. (2004) 'Role of tumour necrosis factor gene polymorphisms (-308 and -238) in breast cancer susceptibility and severity'. Breast Cancer Research, 6 (4):R395-R400. [Details]
Gordon, A and Kiss-Toth, E and Wilson, AG and Stockley, I and Hamer, AJ and Eastell, R and Wilkinson, JM (2004) 'A SINGLE NUCLEOTIDE POLYMORPHISM AT--238 IN THE TNF GENE INFLUENCES PROMOTER RESPONSE TO POLYETHYLENE PARTICLES IN-VITRO'. Journal of Bone \& Joint Surgery, British Volume, 86 (SUPP I):71-71. [Details]
Gordon, A and Wilson, AG and Stockley, I and Hamer, AJ and Macdonald, DA and Eastell, R and Wilkinson, JM (2004) 'POLYMORPHISM AT+ 3954 IN THE IL-1B GENE AND RISK OF ASEPTIC LOOSENING AFTER TOTAL HIP ARTHROPLASTY'. Journal of Bone \& Joint Surgery, British Volume, 86 (SUPP I):70-70. [Details]
Kraus VB, Li YJ, Martin ER, Jordan JM, Renner JB, Doherty M, Wilson AG, Moskowitz R, Hochberg M, Loeser R, Hooper M, Sundseth S. (2004) 'Articular hypermobility is a protective factor for hand osteoarthritis'. Arthritis and Rheumatism, 50 (7):2178-2183. [Details]
Kilding R, Iles MM, Timms JM, Worthington J, Wilson AG. (2004) 'Additional genetic susceptibility for rheumatoid arthritis telomeric of the DRB1 locus'. Arthritis and Rheumatism, 50 (3):763-769. [Details]
Sabroe I, Whyte MK, Wilson AG, Dower SK, Hubbard R, Hall I. (2004) 'Toll-like receptor (TLR) 4 polymorphisms and COPD'. Thorax, 59 (1):81-81. [Details]
Tazi-Ahnini R, Timms JM, Cox A, Wilson AG. (2003) 'Identification of novel single nucleotide polymorphisms within the NOTCH4 gene and determination of association with MHC alleles'. Immunogenetics, 30 (2):101-105. [Details]
Wilkinson, JM and Wilson, AG and Stockley, I and Scott, IR and Macdonald, DA and Hamer, AJ and Eastell, R (2003) 'GENETIC VARIATION IN THE TNF GENE AND ASEPTIC LOOSENING AFTER TOTAL HIP ARTHROPLASTY'. Orthopaedic Proceedings, 85 (SUPP I):60. [Details]
Kilding R, Akil M, Till S, Amos R, Winfield J, Iles MM, Wilson AG. (2003) 'A biologically important single nucleotide polymorphism within the toll-like receptor-4 gene is not associated with rheumatoid arthritis'. Clinical and Experimental Rheumatology, 21 (3):340-342. [Details]
Wilkinson JM, Wilson AG, Stockley I, Scott IR, Macdonald DA, Hamer AJ, Duff GW, Eastell R. (2003) 'Variation in the TNF gene promoter and risk of osteolysis after total hip arthroplasty'. Journal of Bone and Mineral Research, 18 (11):1995-2001. [Details]
Tazi-Ahnini R, Cork MJ, Wengraf D, Wilson AG, Gawkrodger DJ, Birch MP, Messenger AG, McDonagh AJ. (2003) 'Notch4, a non-HLA gene in the MHC is strongly associated with the most severe form of alopecia areata'. Human Genetics, 112 (4):400-403. [Details]
Low AS, Gonzalez-Gay MA, Akil M, Amos RS, Bax DE, Cannings C, Hajeer A, Till SH, Winfield J, Ollier WE, Wilson AG. (2002) 'TNF +489 polymorphism does not contribute to susceptibility to rheumatoid arthritis'. Clinical and Experimental Rheumatology, 20 (6):829-832. [Details]
Sabroe I, Parker LC, Wilson AG, Whyte MK, Dower SK. (2002) 'Toll-like receptors: their role in allergy and non-allergic inflammatory disease'. Clinical Experimental Allergy, 32 (7):984-989. [Details]
Kemp EH, Herd LM, Waterman EA, Wilson AG, Weetman AP, Watson PP. (2002) 'Immunoscreening of phage-displayed cDNA-encoded polypeptides identifies B cell targets in autoimmune disease'. Biochemical and Biophysical Research Communications, 298 (1):169-177. [Details]
Low AS, Azmy I, Sharaf N, Cannings C, Wilson AG. (2002) 'Association between two tumour necrosis factor intronic polymorphisms and HLA alleles'. Immunogenetics, 29 (1):31-34. [Details]
Vankemmelbeke MN, Holen I, Wilson AG, Ilic MZ, Handley CJ, Kelner GS, Clark M, Liu C, Maki RA, Burnett D, Buttle DJ. (2001) 'Expression and activity of ADAMTS-5 in synovium'. European Journal of Biochemistry, 268 (5):1259-1268. [Details]
Read RC, Pullin J, Gregory S, Borrow R, Kaczmarski EB, di Giovine FS, Dower SK, Cannings C, Wilson AG. (2001) 'A functional polymorphism of toll-like receptor 4 is not associated with likelihood or severity of meningococcal disease'. Journal of Infectious Diseases, 184 (5):640-642. [Details]
Summers KE, Goff LK, Wilson AG, Gupta RK, Lister TA, Fitzgibbon J. (2001) 'The frequency of the Bcl-2/IgH MBR rearrangement in normal individuals - implications for the monitoring of follicular lymphoma'. Clinical oncology, 19 (2):420-424. [Details]
Millard TP, Kondeatis E, Cox A, Wilson AG, Grabczynska SA, Carey BS, Lewis CM, Khamashta MA, Duff GW, Hughes GR, Hawk JL, Vaughan RW, McGregor JM. (2001) 'A candidate gene analysis of three related photosensitivity disorders: cutaneous lupus erythematosus, polymorphic light eruption and actinic prurigo'. British Journal of Dermatology, 145 (2):229-236. [Details]
Janer M, Cowland A, Picard J, Campbell D, Pontarotti P, Newsom-Davis J, Bunce M, Welsh K, Demaine A, Wilson AG, Willcox N. (1999) 'A susceptibility region for myasthenia gravis extending into the HLA-class I sector telomeric to HLA-C'. Human immunology, 60 (9):909-917. [Details]
Wilson AG, Duff GW. (1999) 'Relevance of tumour necrosis factor alpha gene polymorphism in rheumatic disease'. Rheumatology (Oxford, England), 38 (7):681-683. [Details]
Wilson AG, Symons JA, McDowell TL, McDevitt HO, Duff GW. (1997) 'Effects of a polymorphism in the human tumor necrosis factor alpha promoter on transcriptional activation'. Proceedings of the National Academy of Sciences of the United States of America, 94 (7):3195-3199. [Details]
McManus, R., A.G. Wilson, J. Mansfield, D.G. Weir, G.W. Duff, and D. Kelleher (1996) 'TNF2, a polymorphism of the tumour necrosis-alpha gene promoter, is a component of the celiac disease major histocompatibility complex haplotype'. European Journal of Immunology, 26 :2113-2118. [Details]
Clay FE, Cork MJ, Wilson AG, Crane AM, Lewis F, Harrington CI, Duff GW. (1996) 'Promoter region polymorphism in the human TNF-alpha gene is not associated with lichen sclerosus'. Experimental Dermatology, 5 (4):227-229. [Details]
Wilson, AG and Duff, GW (1996) 'Genetics of tumour necrosis factor in systemic lupus erythematosus'. Lupus, 5 (2):87-88. [Details]
Stark, Marshall and Jones, SarahJane and Johansen, Karl and Blake, Lian and Shaw, Robert and Wilson, AnthonyG and Duff, GordonW (1995) 'Tumour necrosis factor'. The Lancet, 345 (8950):648-649. [Details]
Wilson AG, de Vries N, van de Putte LB, Duff GW. (1995) 'A tumour necrosis factor alpha polymorphism is not associated with rheumatoid arthritis'. Annals of the Rheumatic Diseases, 54 (7):601-603. [Details]
Wilson AG, Clay FE, Crane AM, Cork MJ, Duff GW. (1995) 'Comparative genetic association of human leukocyte antigen class II and tumor necrosis factor-alpha with dermatitis herpetiformis'. Journal of Investigative Dermatology, 104 (5):856-858. [Details]
Wilson, Anthony G and Duff, Gordon W (1995) 'Genetic traits in common diseases'. British Medical Journal, 310 (6993):1482. [Details]
Cox A, Gonzalez AM, Wilson AG, Wilson RM, Ward JD, Artlett CM, Welsh K, Duff GW. (1994) 'Comparative analysis of the genetic associations of HLA-DR3 and tumour necrosis factor alpha with human IDDM'. Diabetologia, 37 (5):500-503. [Details]
Wilson AG, di Giovine FS, Duff GW. (1994) 'Genetics of tumour necrosis factor-alpha in autoimmune, infectious, and neoplastic diseases'. Journal of Inflammation, 45 (1):1-12. [Details]
Wilson AG, Gordon C, di Giovine FS, de Vries N, van de Putte LB, Emery P, Duff GW. (1994) 'A genetic association between systemic lupus erythematosus and tumor necrosis factor alpha'. European Journal of Immunology, 24 (1):191-195. [Details]
Mansfield JC, Holden H, Tarlow JK, Di Giovine FS, McDowell TL, Wilson AG, Holdsworth CD, Duff GW. (1994) 'Novel genetic association between ulcerative colitis and the anti-inflammatory cytokine interleukin-1 receptor antagonist'. Gastroenterology, 106 (3):637-637. [Details]
Wilson AG, de Vries N, Pociot F, di Giovine FS, van der Putte LB, Duff GW. (1993) 'An allelic polymorphism within the human tumor necrosis factor alpha promoter region is strongly associated with HLA A1, B8, and DR3 alleles'. Experimental Medicine, 177 (2):557-560. [Details]
Pociot F, Wilson AG, Nerup J, Duff GW. (1993) 'No independent association between a tumor necrosis factor-alpha promotor region polymorphism and insulin-dependent diabetes mellitus'. European Journal of Immunology, 23 (11):3050-3053. [Details]
Bell AL, Markey GM, McCaigue MD, Middleton D, McCormick JA, Wilson AG, Morris TC. (1992) 'Heredofamilial deficiency of monocyte esterase in patients with rheumatoid arthritis'. Annals of the Rheumatic Diseases, 51 (5):668-670. [Details]
Wilson AG, di Giovine FS, Blakemore AI, Duff GW. (1992) 'Single base polymorphism in the human tumour necrosis factor alpha (TNF alpha) gene detectable by NcoI restriction of PCR product'. Human Molecular Genetics, 1 (5):353-353. [Details]
                                                                                                                                           

Research

Research Interests

My research interests include the genetic background of rheumatoid arthritis. Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease characterised by joint inflammation which frequently leads to joint damage, significant morbidity and increased mortality. The aetiology is multifactorial with a substantial genetic contribution. I am also interested in pharmacogenetics, specifically the identification of biomarkers predictive of response to Methotrexate and anti-TNF.

Research Projects

Sponsor : Health Research Board (HRB)
Arthritis Ireland
Title : An investigation of the mechanisms linking C5orf30 with tissue damage in RA
Start Date / End Date : 01-APR-17 / 31-MAR-20
Sponsor : University College Dublin (UCD)
Title : OBRSS Research Support Scheme
Start Date / End Date : 01-NOV-16 / 31-OCT-19
Sponsor : Enterprise Ireland (EI)
Title : Envionmental and Ageing influences on Systemic Inflammation
Start Date / End Date : 30-JAN-14 / 29-OCT-14
Sponsor : University College Dublin Foundation Ltd.
Title : `Therapeutic potential of microRNA blockade in Inflammatory Arthritis¿
Start Date / End Date : 01-SEP-14 / 31-AUG-16
Sponsor : University College Dublin Foundation Ltd.
Title : Newman Fellowship in Down¿s Arthropathy
Start Date / End Date : 01-SEP-15 / 13-JAN-18
Sponsor : University College Dublin (UCD)
Title : Start Up Funds
Start Date / End Date : 01-AUG-13 / 30-SEP-19
Sponsor : University College Dublin (UCD)
Title : Discretionary
Start Date / End Date : 30-SEP-13 / 01-SEP-20
 

Current Postgraduate Students

Sian Cregan, Master of Science (MSc)   -   Thesis Supervisor

Teaching

   

Enhancement of Teaching

External Examiner MSc in Molecular Medicine Trinity College Dublin
     

Collaborators

Internal Collaborators

  • Prof Doug Veale, Director of Translational Research of the DAMC, Professor of Medicine and Consultant Rheumatologist
  • Prof Oliver FitzGerald, Consultant Rheumatologist and Newman Clinical Research Professor
  • Prof Steve Pennington, Professor Of Proteomics
  • Dr Eamonn Molloy, Consultant Rheumatologist
  • Prof Geraldine McCarthy, UCD Clinical Professor and Consultant Rheumatologist
  • Dr Anne Barbara Mongey, Consultant Rheumatologist
  • Dr Suzanne Donnelly, UCD Director of Clinical Education and Consultant Rheumatologist
  • Dr Sinead Ryan, Lecturer in Biosciences
  • Prof Denis Sheilds, Professor of Clinical Bioinformatics
  • Dr Ricardo Segurado, Lecturer in Public Health Biostatistics
  • Dr David O'Connell, Lecturer in Biomolecular & Biomedical Science

External Collaborators

  • Prof Ursula Fearon, Trinity College Dublin
  • Prof Luke O'Neill, Trinity College Dublin
  • Dr Munitta Muthana, University of Sheffield
  • Prof Anne Barton, University of Manchester

Industry Collaborations:

  • GlaxoSmithKline 
  • Pfizer
  • UCB
  • Merck
  • Bristol-Myers Squibb
  • AbbVie