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Researchers at UCD

Johan Ericsson

Sfi Stokes Professor

School Of Medicine
Conway Institute
Belfield
Dublin 4

Tel: +353 1 7166753
Email: johan.ericsson@ucd.ie

Publications

     

Peer Reviewed Journals

Welcker M, Larimore EA;Swanger J;Bengoechea-Alonso MT;Grim JE;Ericsson J;Zheng N;Clurman BE (2013) 'Fbw7 dimerization determines the specificity and robustness of substrate degradation'. Genes and Development, 27 (23):2531-2536. [DOI] [Details]
Calvisi, DF,Wang, CM,Ho, C,Ladu, S,Lee, SA,Mattu, S,Destefanis, G,Delogu, S,Zimmermann, A,Ericsson, J,Brozzetti, S,Staniscia, T,Chen, X,Dombrowski, F,Evert, M; (2011) 'Increased Lipogenesis, Induced by AKT-mTORC1-RPS6 Signaling, Promotes Development of Human Hepatocellular Carcinoma'. Journal of Gastroenterology, 140 :1071-542. [DOI] [Details]
Mu Y, Sundar R;Thakur N;Ekman M;Gudey SK;Yakymovych M;Hermansson A;Dimitriou H;Bengoechea-Alonso MT;Ericsson J;Heldin CH;Landstr¿¿m M (2011) 'TRAF6 ubiquitinates TGF¿¿ type I receptor to promote its cleavage and nuclear translocation in cancer'. Nature Communications, 2 . [DOI] [Details]
Calvisi DF, Wang C, Ho C, Ladu S, Lee SA, Mattu S, Destefanis G, Delogu S, Zimmermann A, Ericsson J, Brozzetti S, Staniscia T, Chen X, Dombrowski F, Evert M; (2010) 'Increased Lipogenesis, Induced by AKT-mTORC1-RPS6 Signaling, Promotes Development of Human Hepatocellular Carcinoma'. Journal of Gastroenterology, . [DOI] [Details]
Fenton TR, Gwalter J, Ericsson J, Gout IT.; (2010) 'Histone acetyltransferases interact with and acetylate p70 ribosomal S6 kinases in vitro and in vivo'. International Journal of Biochemistry & Cell Biology, . [Details]
Bengoechea-Alonso MT, Ericsson J.; (2010) 'The ubiquitin ligase Fbxw7 controls adipocyte differentiation by targeting C/EBPalpha for degradation'. Proceedings of the National Academy of Sciences of the United States of America, . [Details]
Bengoechea-Alonso, MT,Ericsson, J; (2010) 'Tumor suppressor Fbxw7 regulates TGF beta signaling by targeting TGIF1 for degradation'. Oncogene, 29 :5322-5328. [DOI] [Details]
Ericsson JD, Janmaat AF, Lowenberger C, Myers JH; (2009) 'Is decreased generalized immunity a cost of Bt resistance in cabbage loopers Trichoplusia ni?'. Journal of Invertebrate Pathology, 100 (2):61-67. [DOI] [Details]
Bengoechea-Alonso MT, Ericsson J.; (2009) 'Quelling cholesterol pathway fends off brain damage'. Nature Medicine, . [Details]
Bengoechea-Alonso MT, Ericsson J; (2009) 'A phosphorylation cascade controls the degradation of active SREBP1'. Journal of Biological Chemistry, 284 (9):5885-5895. [DOI] [Details]
Motallebipour M, Enroth S, Punga T, Ameur A, Koch C, Dunham I, Komorowski J, Ericsson J, Wadelius C; (2009) 'Novel genes in cell cycle control and lipid metabolism with dynamically regulated binding sites for sterol regulatory element-binding protein 1 and RNA polymerase II in HepG2 cells detected by chromatin immunoprecipitation with microarray detection'. FEBS Journal, 276 (7):1878-1890. [DOI] [Details]
Bengoechea-Alonso MT, Ericsson J; (2009) 'Quelling cholesterol pathway fends off brain damage'. Nature Medicine, 15 (12):1358-1359. [DOI] [Details]
Grim JE, Gustafson MP, Hirata RK, Hagar AC, Swanger J, Welcker M, Hwang HC, Ericsson J, Russell DW, Clurman BE; (2008) 'Isoform- and cell cycle-dependent substrate degradation by the Fbw7 ubiquitin ligase'. Journal of Cell Biology, 181 (6):913-920. [DOI] [Details]
Furuta E, Pai SK, Zhan R, Bandyopadhyay S, Watabe M, Mo YY, Hirota S, Hosobe S, Tsukada T, Miura K, Kamada S, Saito K, Iiizumi M, Liu W, Ericsson J, Watabe K; (2008) 'Fatty acid synthase gene is up-regulated by hypoxia via activation of Akt and sterol regulatory element binding protein-1'. Cancer Research, 68 (4):1003-1011. [DOI] [Details]
Bengoechea-Alonso MT, Ericsson J; (2007) 'SREBP in signal transduction: cholesterol metabolism and beyond'. Current Opinion in Cell Biology, 19 (2):215-222. [DOI] [Details]
Bengoechea-Alonso MT, Ericsson J; (2006) 'Cdk1/cyclin B-mediated phosphorylation stabilizes SREBP1 during mitosis'. Cell Cycle, 5 (15):1708-1718. [Details]
Punga T, Bengoechea-Alonso MT, Ericsson J; (2006) 'Phosphorylation and ubiquitination of the transcription factor sterol regulatory element-binding protein-1 in response to DNA binding'. Journal of Biological Chemistry, 281 (35):25278-25286. [DOI] [Details]
Bengoechea-Alonso MT, Punga T, Ericsson J; (2005) 'Hyperphosphorylation regulates the activity of SREBP1 during mitosis'. Proceedings of the National Academy of Sciences of the United States of America, 102 (33):11681-11686. [DOI] [Details]
Sundqvist A, Bengoechea-Alonso MT, Ye X, Lukiyanchuk V, Jin J, Harper JW, Ericsson J; (2005) 'Control of lipid metabolism by phosphorylation-dependent degradation of the SREBP family of transcription factors by SCF(Fbw7)'. Cell Metabolism, 1 (6):379-391. [DOI] [Details]
Pandey RR, Ceribelli M, Singh PB, Ericsson J, Mantovani R, Kanduri C; (2004) 'NF-Y regulates the antisense promoter, bidirectional silencing, and differential epigenetic marks of the Kcnq1 imprinting control region'. Journal of Biological Chemistry, 279 (50):52685-52693. [DOI] [Details]
Sundqvist A, Ericsson J; (2003) 'Transcription-dependent degradation controls the stability of the SREBP family of transcription factors'. Proceedings of the National Academy of Sciences of the United States of America, 100 (24):13833-13838. [DOI] [Details]
Kurisaki K, Kurisaki A, Valcourt U, Terentiev AA, Pardali K, Ten Dijke P, Heldin CH, Ericsson J, Moustakas A; (2003) 'Nuclear factor YY1 inhibits transforming growth factor beta- and bone morphogenetic protein-induced cell differentiation'. Molecular Cell, 23 (13):4494-4510. [Details]
Kast HR, Nguyen CM, Anisfeld AM, Ericsson J, Edwards PA; (2001) 'CTP:phosphocholine cytidylyltransferase, a new sterol- and SREBP-responsive gene'. Journal of Lipid Research, 42 (8):1266-1272. [Details]
Heldin CH, Ericsson J; (2001) 'Signal transduction. RIPping tyrosine kinase receptors apart'. Science, 294 (5549):2111-2113. [DOI] [Details]
Itoh S, Ericsson J, Nishikawa J, Heldin CH, ten Dijke P; (2000) 'The transcriptional co-activator P/CAF potentiates TGF-beta/Smad signaling'. Nucleic Acids Research, 28 (21):4291-4298. [Details]
Edwards PA, Ericsson J; (1999) 'Sterols and isoprenoids: signaling molecules derived from the cholesterol biosynthetic pathway'. Annual Review of Biochemistry, 68 :157-185. [DOI] [Details]
Ericsson J, Usheva A, Edwards PA; (1999) 'YY1 is a negative regulator of transcription of three sterol regulatory element-binding protein-responsive genes'. Journal of Biological Chemistry, 274 (20):14508-14513. [Details]
Bylund J, Ericsson J, Oliw EH; (1998) 'Analysis of cytochrome P450 metabolites of arachidonic and linoleic acids by liquid chromatography-mass spectrometry with ion trap MS'. Analytical Biochemistry, 265 (1):55-68. [Details]
Edwards PA, Ericsson J; (1998) 'Signaling molecules derived from the cholesterol biosynthetic pathway: mechanisms of action and possible roles in human disease'. Current Opinion in Lipidology, 9 (5):433-440. [Details]
Ericsson J, Greene JM, Carter KC, Shell BK, Duan DR, Florence C, Edwards PA; (1998) 'Human geranylgeranyl diphosphate synthase: isolation of the cDNA, chromosomal mapping and tissue expression'. Journal of Lipid Research, 39 (9):1731-1739. [Details]
Ericsson J, Edwards PA; (1998) 'CBP is required for sterol-regulated and sterol regulatory element-binding protein-regulated transcription'. Journal of Biological Chemistry, 273 (28):17865-17870. [Details]
Jackson SM, Ericsson J, Mantovani R, Edwards PA; (1998) 'Synergistic activation of transcription by nuclear factor Y and sterol regulatory element binding protein'. Journal of Lipid Research, 39 (4):767-776. [Details]
Welch CL, Xia YR, Edwards PA, Lusis AJ, Ericsson J; (1998) 'Assignment of Gpam to distal mouse chromosome 19 by linkage analysis'. Mammalian genome : official journal of the International Mammalian Genome Society, 9 (1). [Details]
Ericsson J, Jackson SM, Kim JB, Spiegelman BM, Edwards PA; (1997) 'Identification of glycerol-3-phosphate acyltransferase as an adipocyte determination and differentiation factor 1- and sterol regulatory element-binding protein-responsive gene'. Journal of Biological Chemistry, 272 (11):7298-7305. [Details]
Jackson SM, Ericsson J, Edwards PA; (1997) 'Signaling molecules derived from the cholesterol biosynthetic pathway'. Sub-Cellular Biochemistry, 28 :1-21. [Details]
Ericsson J, Jackson SM, Edwards PA; (1996) 'Synergistic binding of sterol regulatory element-binding protein and NF-Y to the farnesyl diphosphate synthase promoter is critical for sterol-regulated expression of the gene'. Journal of Biological Chemistry, 271 (40):24359-24364. [Details]
Jackson SM, Ericsson J, Metherall JE, Edwards PA; (1996) 'Role for sterol regulatory element binding protein in the regulation of farnesyl diphosphate synthase and in the control of cellular levels of cholesterol and triglyceride: evidence from sterol regulation-defective cells'. Journal of Lipid Research, 37 (8):1712-1721. [Details]
Ericsson J, Jackson SM, Lee BC, Edwards PA; (1996) 'Sterol regulatory element binding protein binds to a cis element in the promoter of the farnesyl diphosphate synthase gene'. Proceedings of the National Academy of Sciences of the United States of America, 93 (2):945-950. [Details]
Jackson SM, Ericsson J, Osborne TF, Edwards PA; (1995) 'NF-Y has a novel role in sterol-dependent transcription of two cholesterogenic genes'. Journal of Biological Chemistry, 270 (37):21445-21448. [Details]
Ericsson J, Holm LE, Stenbeck M; (1995) 'Thyroid, endocrine glands, bone, muscle and connective tissue'. Acta oncologica (Stockholm, Sweden), 34 Suppl 4 :95-108. [Details]
Ericsson J, Stenbeck M; (1995) 'Eye, brain and nervous system'. Acta oncologica (Stockholm, Sweden), 34 Suppl 4 :83-93. [Details]
Ericsson J, Stenbeck M; (1995) 'Urinary tract'. Acta oncologica (Stockholm, Sweden), 34 Suppl 4 :67-73. [Details]
Ericsson J, Steinbeck M; (1995) 'Lymphatic and haematopoietic tissues'. Acta oncologica (Stockholm, Sweden), 34 Suppl 4 :109-124. [Details]
Thelin A, Peterson E, Hutson JL, McCarthy AD, Ericsson J, Dallner G; (1994) 'Effect of squalestatin 1 on the biosynthesis of the mevalonate pathway lipids'. Biochimica et biophysica acta, 1215 (3):245-249. [Details]
Thelin A, Runquist M, Ericsson J, Swiezewska E, Dallner G; (1994) 'Age-dependent changes in rat liver prenyltransferases'. Mechanisms of Ageing and Development, 76 (2-3):165-176. [Details]
Spear DH, Ericsson J, Jackson SM, Edwards PA; (1994) 'Identification of a 6-base pair element involved in the sterol-mediated transcriptional regulation of farnesyl diphosphate synthase'. Journal of Biological Chemistry, 269 (40):25212-25218. [Details]
Andersson M, Ericsson J, Appelkvist EL, Schedin S, Chojnacki T, Dallner G; (1994) 'Modulations in hepatic branch-point enzymes involved in isoprenoid biosynthesis upon dietary and drug treatments of rats'. Biochimica et biophysica acta, 1214 (1):79-87. [Details]
Krisans SK, Ericsson J, Edwards PA, Keller GA; (1994) 'Farnesyl-diphosphate synthase is localized in peroxisomes'. Journal of Biological Chemistry, 269 (19):14165-14169. [Details]
Runquist M, Ericsson J, Thelin A, Chojnacki T, Dallner G; (1994) 'Isoprenoid biosynthesis in rat liver mitochondria. Studies on farnesyl pyrophosphate synthase and trans-prenyltransferase'. Journal of Biological Chemistry, 269 (8):5804-5809. [Details]
Ericsson J, Runquist M, Thelin A, Andersson M, Chojnacki T, Dallner G; (1993) 'Distribution of prenyltransferases in rat tissues. Evidence for a cytosolic all-trans-geranylgeranyl diphosphate synthase'. Journal of Biological Chemistry, 268 (2):832-838. [Details]
Ericsson J, Appelkvist EL, Runquist M, Dallner G; (1993) 'Biosynthesis of dolichol and cholesterol in rat liver peroxisomes'. Biochimie, 75 (3-4):167-173. [Details]
Ericsson J, Dallner G; (1993) 'Distribution, biosynthesis, and function of mevalonate pathway lipids'. Sub-Cellular Biochemistry, 21 :229-272. [Details]
Ericsson J, Thelin A, Chojnacki T, Dallner G; (1992) 'Substrate specificity of cis-prenyltransferase in rat liver microsomes'. Journal of Biological Chemistry, 267 (27):19730-19735. [Details]
Ericsson J, Appelkvist EL, Thelin A, Chojnacki T, Dallner G; (1992) 'Isoprenoid biosynthesis in rat liver peroxisomes. Characterization of cis-prenyltransferase and squalene synthetase'. Journal of Biological Chemistry, 267 (26):18708-18714. [Details]
Runquist M, Ericsson J, Thelin A, Chojnacki T, Dallner G; (1992) 'Biosynthesis of trans,trans,trans-geranylgeranyl diphosphate by the cytosolic fraction from rat tissues'. Biochemical and Biophysical Research Communications, 186 (1):157-165. [Details]
Tulinius H, Storm HH, Pukkala E, Andersen A, Ericsson J; (1992) 'Cancer in the Nordic countries, 1981-86. A joint publication of the five Nordic Cancer Registries'. APMIS, 31 :1-194. [Details]
Ericsson J, Thelin A, Chojnacki T, Dallner G; (1991) 'Characterization and distribution of cis-prenyl transferase participating in liver microsomal polyisoprenoid biosynthesis'. European journal of biochemistry / FEBS, 202 (3):789-796. [Details]
Ericsson J, Scallen TJ, Chojnacki T, Dallner G; (1991) 'Involvement of sterol carrier protein-2 in dolichol biosynthesis'. Journal of Biological Chemistry, 266 (16):10602-10607. [Details]
Jakobsson A, Ericsson J, Dallner G; (1990) 'Metabolism of fatty acids and their incorporation into phospholipids of the mitochondria and endoplasmic reticulum in isolated hepatocytes determined by isolation of fluorescence derivatives'. Biochimica et biophysica acta, 1046 (3):277-287. [Details]
Eggens I, Ericsson J, Tollbom O; (1988) 'Cytidine 5'-triphosphate-dependent dolichol kinase and dolichol phosphatase activities and levels of dolichyl phosphate in microsomal fractions from highly differentiated human hepatomas'. Cancer Research, 48 (12):3418-3424. [Details]
Jakobsson A, Ericsson J, Dallner G; (1988) 'Studies on fatty acid elongation and desaturation in rat liver phospholipids in vivo'. Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry, 42 (2):130-132. [Details]
McLaughlin JK, Malker HS, Linet MS, Ericsson J, Stone BJ, Weiner J, Blot WJ, Fraumeni JF Jr; (1988) 'Multiple myeloma and occupation in Sweden'. Environmental Health: A Global Access Science Source, 43 (1):7-10. [Details]
Ericsson J, Chojnacki T, Dallner G; (1987) 'Separation and quantitation of dolichyl esters by high-performance liquid chromatography'. Analytical Biochemistry, 167 (2):222-227. [Details]
Edlund C, Ericsson J, Dallner G; (1987) 'Changes in hepatic dolichol and dolichyl monophosphate caused by treatment of rats with inducers of the endoplasmic reticulum and peroxisomes and during ontogeny'. Chemico-Biological Interactions, 62 (2):191-208. [Details]
Abok K, Brunk U, Jung B, Ericsson J; (1984) 'Morphologic and histochemical studies on the differing radiosensitivity of ductular and acinar cells of the rat submandibular gland'. Virchows Archiv B Cell Pathology Including Molecular Pathology, 45 (4):443-460. [Details]
Ericsson J, Malker B, Rengby L; (1983) '[The cancer registry for 25 years: Changes in the cancer scene in Sweden 1960-1980]'. Lakartidningen, 80 (45):4269-4276. [Details]
Abok K, Blomquist E, Ericsson J, Brunk U; (1983) 'Macrophage radiosensitivity in culture as a function of exposure to ionic iron'. Virchows Archiv B Cell Pathology Including Molecular Pathology, 42 (2):119-129. [Details]
       

Editorial

Bengoechea-Alonso, MT,Ericsson, J; (2009) Quelling cholesterol pathway fends off brain damage. Editorial [DOI] [Details]
                                                                                   

Research

Research Interests

We work on the SREBP family of transcription factors. These proteins control cholesterol and lipid metabolism and play critical roles during adipocyte differentiation and insulin-dependent gene expression. Disturbances in lipid metabolism are at the very core of several major health issues facing modern society, including cardiovascular disease, obesity and diabetes. Thus, the factors and signals that regulate the function of the SREBP family of proteins are very relevant to metabolic disease. 

Research Projects

Sponsor : Science Foundation Ireland (SFI)
Title : Diabetes and vascular biology
Start Date / End Date : 01-DEC-08 / 30-NOV-13
Sponsor : University College Dublin (UCD)
Title : Life Sciences Start Up Funds
Start Date / End Date : 01-OCT-08 / 30-SEP-10
Sponsor : Ludwig Institute for Cancer Research (LICR)
Title : Factors Regulating Fbw7
Start Date / End Date : 01-JAN-09 / 31-DEC-17
Sponsor : Science Foundation Ireland (SFI)
Title : Identification of novel mechanisms to control the SREBP family of transcription factors, key regulators of lipid metabolism
Start Date / End Date : 01-FEB-11 / 31-JAN-17