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Researchers at UCD

researcher

John M P Hyland

Associate Clinical Professor

School Of Medicine
St Vincent's Hospital
Elm Park
Dublin 4

Tel:
Email: john.hyland@ucd.ie

Professional

         

Conference Contributions

Nolan, I. M., Fox, E. J. P., Moss, C., Leahy, D. T., Geraghty, R., Mulcahy, H. E., Hyland, J. P. M., Fennelly, D., Sheahan, K., O Donoghue D., Argraves, W. S., and Gallagher, W. M. presented by I. M. Nolan.; (2003) Biomarker identification in colon cancer via real-time reverse transcriptase-PCR. [Poster Presentation], Conference on Common Molecular Mechanisms in Inflammation & Malignancy, St. Vincent?s University Hospital, Dublin , 21-NOV-03.
Nolan, I. M., Fox, E. J. P., Moss, C., Leahy, D. T., Geraghty, R., Mulcahy, H. E., Hyland, J. P. M., Fennelly, D., Sheahan, K., O Donoghue D., Argraves, W. S., and Gallagher, W. M. presented by I. M. Nolan.; (2003) Expression levels of fibulin-1 and 4 mRNA in colon cancer tissues determined by real-time quantitative reverse transcriptase-PCR. [Poster Presentation], 3rd Annual Conway Institute Festival of Research, University College Dublin , 10-SEP-03 - 11-SEP-03.
Coss A, Sheahan K, Sullivan S, Fox E, Hyland J, O'Donoghue D, Leahy D, Mulcahy H, O'Sullivan J; (2007) Alterations of the topoisomerase II alpha gene and protein in colorectal cancer. [Poster Presentation (Refereed)], Irish Association for Cancer Research Annual Meeting, Cork, March, 2007 , 02-MAR-07.
               

Publications

     

Peer Reviewed Journals

Moriarty, D; Ettarh, R; Sheahan, K; Hyland, J; O'Donoghue, DP; Baird, AW; ; (1998) 'Structural associations between mast cells and enteric nerves in normal and inflamed human colon'. Journal of Gastroenterology, 114 (4):400-400. [Details]
O'Riordan, A.M., Quinn, T., Hyland, J.M., O'Donoghue, D.P., Baird, A.W.; (2001) 'Sources of calcium in neurokinin A-induced contractions of human colonic smooth muscle in vitro'. American Journal of Gastroenterology, 96 :3117-3121. [Details]
Bakheit, S; Dolan, J; O'Sullivan, J; Keating, G; Gorman, J; Mulcahy, H; Hyland, J; O'Donoghue, D; Sheahan, K; ; (2005) 'Glucose transporter 1 (GLUT-1) expression and cellular localization in early colorectal neoplasia'. Modern Pathology, 18 (NA):97-98. [Details]
Bakheit, S; Dolan, J; O'Sullivan, J; Keating, G; Gorman, J; Mulcahy, H; Hyland, J; O'Donoghue, D; Sheahan, K; ; (2005) 'Glucose Transporter 1 (GLUT-1) expression and cellular localization in early colorectal neoplasia'. Laboratory Investigation, 85 (NA):97-98. [Details]
Banville, N, Geraghty, R, Fox, E, Leahy, DT, Green, A, Keegan, D, Geoghegan, J, O'Donoghue, D, Hyland, J, Sheahan, K, ; (2006) 'Medullary carcinoma of the pancreas in a man with hereditary nonpolyposis colorectal cancer due to a mutation of the MSH2 mismatch repair gene'. Human Pathology, 37 (11):1498-1502. [DOI] [Details]
Sheridan, J, Wang, LM, Fox, E, Dermot, L, Sheahan, K, Hyland, J, O'Donoghue, D, Mulcahy, H, O'Sullivan, J, ; (2006) 'Higher levels of oxidative damage and tumour infiltrating lymphocytes in non-metastatic versus metastatic colorectal tumours'. Modern Pathology, 19 (NA):70-70. [DOI] [Details]
Cullen, G., O'Toole, A.,Keegan, D.,Sheahan, K.,Hyland, J. M., O'Donoghue D, P.; (2007) 'Long-term clinical results of ileocecal resection for Crohn's disease'. Inflammatory Bowel Diseases, 13 (11):1369-1373. [Details]
Lavelle A, Lennon G, O'Sullivan O, Docherty N, Balfe A, Maguire A, Mulcahy HE, Doherty G, O'Donoghue D, Hyland J, Ross RP, Coffey JC, Sheahan K, Cotter PD, Shanahan F, Winter DC, O'Connell PR (2015) 'Spatial variation of the colonic microbiota in patients with ulcerative colitis and control volunteers'. Gut, . [DOI] [Details]
Tevlin R, Larkin JO;Hyland JM;O'Connell PR;Winter DC (2015) 'Brain metastasis from colorectal carcinoma: a single cancer centre experience'. Irish Journal of Medical Science, 184 (3):673-675. [DOI] [Details]
Sheridan J, Walsh P, Kevans D, Cooney T, O'Hanlon S, Nolan B, White A, McDermott E, Sheahan K, O'Shea D, Hyland J, O'Donoghue D, O'Sullivan J, Mulcahy H, Doherty G (2014) 'Determinants of short- and long-term survival from colorectal cancer in very elderly patients'. Journal of Geriatric Oncology, . [DOI] [Details]
Tevlin R, Hanly AM, Rogers AC, Hyland JM, Winter DC, Brannigan AE, O'Connell PR (2014) 'Open versus laparoscopic abdominal rectopexy: an examination of early postoperative outcomes'. Irish Journal of Medical Science, . [DOI] [Details]
Martin P, Noonan S, Mullen MP, Scaife C, Tosetto M, Nolan B, Wynne K, Hyland J, Sheahan K, Elia G, O'Donoghue D, Fennelly D, O'Sullivan J. (2014) 'Predicting response to vascular endothelial growth factor inhibitor and chemotherapy in metastatic colorectal cancer'. BMC Cancer, 14 (887). [DOI] [Details]
O'Toole, A. and Michielsen, A.J. and Nolan, B. and Tosetto, M. and Sheahan, K. and Mulcahy, H.E. and Winter, D.C. and Hyland, J.M. and O'Connell, P.R. and Fennelly, D. and O'Donoghue, D. and O'Sullivan, J. and Doherty, G.A. and Ryan, E.J. (2014) 'Tumour microenvironment of both early- and late-stage colorectal cancer is equally immunosuppressive'. British Journal of Cancer, 111 (5):927-932. Available Online [DOI] [Details]
Kavanagh, D.O. and Carter, M.C. and Keegan, D. and Doherty, G. and Smith, M.J. and Hyland, J.M.P. and Mulcahy, H. and Sheahan, K. and O'Connell, P.R. and O'Donoghue, D.P. and Winter, D.C. (2014) 'Management of colorectal cancer in patients with inflammatory bowel disease'. Techniques in Coloproctology, 18 (1):23-28. Available Online [DOI] [Details]
Rogers, A.C. and Gibbons, D. and Hanly, A.M. and Hyland, J.M. and O'Connell, P.R. and Winter, D.C. and Sheahan, K. (2014) 'Prognostic significance of tumor budding in rectal cancer biopsies before neoadjuvant therapy'. Modern Pathology, 27 (1):156-162. Available Online [DOI] [Details]
Killeen, S. and Martin, S.T. and Hyland, J. and O' Connell, P.R. and Winter, D.C. (2014) 'Clostridium difficile enteritis: A new role for an old foe'. Surgeon, . Available Online [DOI] [Details]
Tevlin, R. and Larkin, J.O. and Hyland, J.M.P. and O'Connell, P.R. and Winter, D.C. (2014) 'Primary colorectal lymphoma - A single centre experience'. The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland, . Available Online [DOI] [Details]
Cotter MB, Kelly ME, O'Connell PR, Hyland J, Winter DC, Sheahan K, Gibbons D (2014) 'Anal intraepithelial neoplasia: a single centre 19 year review'. Colorectal Disease, 16 (10):777-782. [DOI] [Details]
Heetun ZS, Kavanagh D, Keegan D, Mulcahy H, Hyland J, Mc Mahon C, Doherty GA (2013) 'Magnetic resonance colonography for assessment of acute severe colitis in pregnancy'. Medicine, . [DOI] [Details]
Kavanagh, D.O. and Nolan, B. and Judge, C. and Hyland, J.M.P. and Mulcahy, H.E. and O'Connell, P.R. and Winter, D.C. and Doherty, G.A. (2013) 'A comparative study of short- and medium-term outcomes comparing emergent surgery and stenting as a bridge to surgery in patients with acute malignant colonic obstruction'. Diseases of the Colon and Rectum, 56 (4):433-440. Available Online [DOI] [Details]
Lavelle, A. and Lennon, G. and Docherty, N. and Balfe, A. and Mulcahy, H.E. and Doherty, G. and O'Donoghue, D. and Hyland, J.M. and Shanahan, F. and Sheahan, K. and Coffey, J.C. and Winter, D.C. and O'Connell, P.R. (2013) 'Depth-dependent differences in community structure of the human colonic microbiota in health'. PLoS ONE, 8 (11). Available Online [DOI] [Details]
Burke JP, O'Connell RM, Lennon G, Doherty GA, Keegan D, O'Donoghue D, Mulcahy H, Hyland J, Winter DC, Sheahan K, O'Connell PR (2013) 'The influence of CTGF single-nucleotide polymorphisms on outcomes in Crohn's disease'. Annals of Surgery, 258 (5):767-71. [DOI] [Details]
Smith, FM,Chang, KH,Sheahan, K,Hyland, J,O'Connell, PR,Winter, DC (2012) 'The surgical significance of residual mucosal abnormalities in rectal cancer following neoadjuvant chemoradiotherapy'. British Journal of Surgery, 99 :993-1001. [DOI] [Details]
Smith, F.M. and Chang, K.H. and Sheahan, K. and Hyland, J. and O'Connell, P.R. and Winter, D.C. (2012) 'The surgical significance of residual mucosal abnormalities in rectal cancer following neoadjuvant chemoradiotherapy'. British Journal of Surgery, 99 (7):993-1001. Available Online [DOI] [Details]
Kennelly, R.P. and Heeney, A. and White, A. and Fennelly, D. and Sheahan, K. and Hyland, J.M.P. and O'Connell, P.R. and Winter, D.C. (2012) 'A prospective analysis of patient outcome following treatment of T3 rectal cancer with neo-adjuvant chemoradiotherapy and transanal excision'. International Journal of Colorectal Disease, 27 (6):759-764. Available Online [DOI] [Details]
Kavanagh, D.O. and Quinlan, D.M. and Armstrong, J.G. and Hyland, J.M.P. and O'Connell, P.R. and Winter, D.C. (2012) 'Management of synchronous rectal and prostate cancer'. International Journal of Colorectal Disease, 27 (11):1501-1508. Available Online [DOI] [Details]
Smith, F.M. and Sheahan, K. and Hyland, J. and O'Connell, P.R. and Winter, D.C. (2012) 'Authors' reply: The surgical significance of residual mucosal abnormalities in rectal cancer following neoadjuvant chemoradiotherapy (Br J Surg 2012; 99: 993-1001)'. British Journal of Surgery, 99 (11):1601-1602. Available Online [DOI] [Details]
Michielsen, A. J., Noonan, S., Martin, P., Tosetto, M., Marry, J., Biniecka, M., Maguire, A. A., Hyland, J. M., Sheahan, K. D., O'Donoghue, D. P., Mulcahy, H. E., Fennelly, D., Ryan, E. J., O'Sullivan, J. N. (2012) 'Inhibition of dendritic cell maturation by the tumor microenvironment correlates with the survival of colorectal cancer patients following bevacizumab treatment'. Molecular Cancer Therapy, 11 (8):1829-37. Available Online [Details]
Michielsen, A. J., Hogan, A. E., Marry, J., Tosetto, M., Cox, F., Hyland, J. M., Sheahan, K. D., O'Donoghue, D. P., Mulcahy, H. E., Ryan, E. J., O'Sullivan, J. N. (2011) 'Tumour tissue microenvironment can inhibit dendritic cell maturation in colorectal cancer'. PLoS One, 6 (11). Available Online [Details]
Martin, S.T. and Heeney, A. and Pierce, C. and O'Connell, P.R. and Hyland, J.M. and Winter, D.C. (2011) 'Use of an electrothermal bipolar sealing device in ligation of major mesenteric vessels during laparoscopic colorectal resection'. Techniques in Coloproctology, 15 (3):285-289. Available Online [DOI] [Details]
Martin, S.T. and Tevlin, R. and Heeney, A. and Peirce, C. and Hyland, J.M. and Winter, D.C. (2011) 'How i do it: The stapled ileal J pouch at restorative proctocolectomy'. Techniques in Coloproctology, 15 (4):451-454. Available Online [DOI] [Details]
Doherty G, Walsh P, Sheridan J, Kevans D, Keegan D, Nolan B, White A, McDermott E, Sheahan K, O'Shea D, Hyland J, O'Donoghue D, O'Sullivan J, Mulcahy H (2010) 'Clinical and pathological factors associated with colorectal cancer at the upper extreme of life'. Journal of the American Geriatrics Society, 58 (4):794-795. [DOI] [Details]
Canney, A,Sheahan, K,Keegan, D,Tolan, M,Hyland, J,Green, A; (2009) 'Synchronous lung tumours in a patient with metachronous colorectal carcinoma and a germline MSH2 mutation'. Journal of Clinical Pathology - Clinical Molecular Pathology, 62 :471-473. [DOI] [Details]
Coss A, Tosetto M, Fox E, Sapetto-Rebow B, Gorman S, Kennedy B, Lloyd, Hyland J, O'Donoghue D, Sheahan K, Leahy D, Mulcahy H, O'Sullivan J; (2008) 'Increased topoisomerase IIalpha expression in colorectal cancer is associated with advanced disease and chemotherapeutic resistance via inhibition of apoptosis'. CANCER LETT, . [Details]
Fox, E. J.,Leahy, D. T.,Geraghty, R.,Mulcahy, H. E.,Fennelly, D.,Hyland, J. M.,O'Donoghue, D. P.,Sheahan, K.; (2006) 'Mutually exclusive promoter hypermethylation patterns of hMLH1 and O6-methylguanine DNA methyltransferase in colorectal cancer'. Journal of Molecular Diagnostics, 8 (1):68-75. [Details]
Bakhiet, S, O'Sullivan, J, Izzuan, M, Keating, G, Gorman, J, Mulcahy, H, Hyland, J, O'Donoghue, D, Sheahan, K, ; (2006) 'GLUT1 staining pattern incontiguous and non-contiguous colorectal adenomas and their corresponding cancers'. Modern Pathology, 19 (NA):55-55. [DOI] [Details]
R Mofidi, R., Neary, P., Brabazon, A., White, A., Ryan, R., Sheahan, K. ODonoghue, D. & Hyland, J; (2003) 'Prediction of Local Recurrence from Rectal Carcinoma Using an Artificial Neural Network'. Colorectal Disease, 5 (2):17. [Details]
Mofidi, R., Neary, P., Brabazon, A., White, A., Ryan, R.E., Sheehan, S.J., ODonoghue, D. & Hyland, J.M.P.; (2002) 'Assessment of outcome from colorectal carcinoma using an artificial neural network'. British Journal of Surgery, 89 (5):639-640. [Details]
Moriarty, DV; O'Riordan, A; O'Donoghue, DP; Hyland, J; Sheahan, K; Baird, AW; ; (2000) 'Substance P release and modulation of human colonic ion transport: Alterations during IBD'. Journal of Gastroenterology, 118 (4):1105-1105. [Details]
McCormack, G; McCormick, PA; Hyland, J; Baird, A; O'Donoghue, D; ; (1999) 'Patient targeted therapy - The use of cyclosporin in the treatment of acute ulcerative colitis'. Gut, 44 (NA):37-37. [Details]
 

Conference Publications

Milewski MA, Leahy DT, Conroy J, Ennis S, Mulcahy H, Hyland J, O'Donoghue D, Sheahan K.; (2010) MODERN PATHOLOGY 23: Suppl. 1, 156 Genome-wide DNA methylation profiling of sporadic and familial colorectal cancer [Details]
Milewski MA, Leahy DT, Conroy J, Ennis S, Mulcahy H, Hyland J, O'Donoghue D, Sheahan K.; (2010) LABORATORY INVESTIGATION 90: Suppl. 1, 156 Genome-wide DNA methylation profiling of sporadic and familial colorectal cancer [Details]
Leahy DT, Milewski M, Fox E, Geraghty R, Mulcahy H, Hyland J, O'Donoghue D, Sheahan K.; (2009) MODERN PATHOLOGY 22: Suppl. 1, 137 Role of E-Cadherin and Beta-Catenin in Colorectal Cancer Progression [Details]
Geraghty, R; Leahy, D; Keegan, D; Mulcahy, H; O'Donoghue, D; Hyland, J; Sheahan, K; ; (2006) MODERN PATHOLOGY 19: Suppl. 3, 60 Mismatch repair protein and MGMT status inpatients with multiple primary colorectal tumors [Details]
   

Editorial

Cleary, M,Coss, A,Sheahan, K,Mulcahy, H,Hyland, J; (2004) Dieulafoy's lesion in a Meckel's diverticulum. Editorial [Details]
                 

Abstract

Leahy, DT,Milewski, M,Fox, E,Geraghty, R,Mulcahy, H,Hyland, J,O'Donoghue, D,Sheahan, K (2009) Role of E-Cadherin and Beta-Catenin in Colorectal Cancer Progression. Abstract [Details]
Milewski, M,Leahy, D,Conroy, J,Magalhaes, T,Ennis, S,Maguire, A,Mulcahy, H,Hyland, J,O'Donoghue, D,Sheahan, K (2013) Classification of Colorectal Cancer Based on DNA Methylation Array Analysis. Abstract [Details]
Noonan, S,Martin, P,Maguire, A,Biniecka, M,Tosetto, M,Hyland, J,Sheahan, K,O'Donoghue, D,Mulcahy, H,Fennelly, D,O'Sullivan, J (2012) Correlation of markers of oxidative damage and circulating IL6 levels with survival following treatment with bevacizumab in metastatic colorectal cancer patients. Abstract [Details]
Maguire, A,Sheahan, K,Fox, E,Martin, P,Hughes, D,Geraghty, R,Swan, N,Mulcahy, H,Hyland, J,O'Donoghue, D,O'Sullivan, J (2012) Mitochondrial Mutagenesis and Inflammation in the Colorectal Adenoma-Carcinoma Sequence. Abstract [Details]
Milewski, MA,Leahy, DT,Conroy, J,Ennis, S,Mulcahy, H,Hyland, J,O'Donoghue, D,Sheahan, K (2010) Genome-Wide DNA Methylation Profiling of Sporadic and Familial Colorectal Cancer. Abstract [Details]
Maguire, A,Biniecka, M,Geraghty, R,Hyland, J,O'Donoghue, D,Mulcahy, H,O'Sullivan, J,Sheahan, K (2010) Levels of Lipid Peroxidation Are an Important Stimulus in Driving the Adenoma-Carcinoma Sequence in Colorectal Cancer. Abstract [Details]
Bakhiet, S,O'Sullivan, J,Izzuan, M,Keating, G,Gorman, J,Mulcahy, H,Hyland, J,O'Donoghue, D,Sheahan, K (2006) GLUT1 staining pattern incontiguous and non-contiguous colorectal adenomas and their corresponding cancers. Abstract [Details]
Geraghty, R,Leahy, D,Keegan, D,Mulcahy, H,O'Donoghue, D,Hyland, J,Sheahan, K (2006) Mismatch repair protein and MGMT status inpatients with multiple primary colorectal tuniors. Abstract [Details]
Sheridan, J,Wang, LM,Fox, E,Dermot, L,Sheahan, K,Hyland, J,O'Donoghue, D,Mulcahy, H,O'Sullivan, J (2006) Higher levels of oxidative damage and tumour infiltrating lymphocytes in non-metastatic versus metastatic colorectal tumours. Abstract [Details]
Bakheit, S,Dolan, J,O'Sullivan, J,Keating, G,Gorman, J,Mulcahy, H,Hyland, J,O'Donoghue, D,Sheahan, K (2005) Glucose Transporter 1 (GLUT-1) expression and cellular localization in early colorectal neoplasia. Abstract [Details]
Moriarty, DV,O'Riordan, A,O'Donoghue, DP,Hyland, J,Sheahan, K,Baird, AW (2000) Substance P release and modulation of human colonic ion transport: Alterations during IBD. Abstract [Details]
McCormack, G,McCormick, PA,Hyland, J,Baird, A,O'Donoghue, D (1999) Patient targeted therapy - The use of cyclosporin in the treatment of acute ulcerative colitis. Abstract [Details]
Moriarty, D,Ettarh, R,Sheahan, K,Hyland, J,O'Donoghue, DP,Baird, AW (1998) Structural associations between mast cells and enteric nerves in normal and inflamed human colon. Abstract [Details]
                                                             

Letters

Doherty, G,Walsh, P,Sheridan, J,Kevans, D,Keegan, D,Nolan, B,White, A,McDermott, E,Sheahan, K,O'Shea, D,Hyland, J,O'Donoghue, D,O'Sullivan, J,Mulcahy, H (2010) Clinical and Pathological Factors Associated with Colorectal Cancer at the Upper Extreme of Life. Letters [Details]