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Researchers at UCD

Karina Butler

Clinical Professor

School Of Medicine

Tel:
Email: karina.butler@ucd.ie

Biography

Karina Butler is UCD Clinical Professor of Paediatrics, Consultant Paediatrician and Infectious Diseases Specialist at Our Lady's Children's Hospital and The Children's University Hospital, Temple Street. A member of the national immunisation, the national tuberculosis, and scientific advisory committees of the Health Protection Surveillance Centre, she is a steering committee member of the Paediatric European Network for Treatment of AIDS and Infectious Diseases (PENTA-ID), programme committee member for the International Conference of Antimicrobial Agents and Chemotherapy (ICAAC), the European Paediatric Infectious Diseases Society (ESPID) and the European AIDS Conference (EACS).  In 2014 she organised and chaired the 32nd Annual ESPID meeting which brought over 2,500 delegates from 95 countries to Dublin and saw the successful completion of her global study of short cycle therapy (5 days on/2 days off) for HIV infected children.

Publications

     

Peer Reviewed Journals

Butler KM, Gavin P;Coughlan S;Rochford A;Donagh SM;Cunningham O;Poulsom H;Watters S;Klein N (2014) 'Rapid Viral Rebound after 4 Years of Suppressive Therapy in a Seronegative HIV-1 Infected Infant Treated from Birth'. Pediatric Infectious Disease, . [DOI] [Details]
Gleeson LE, Varghese C;Ryan E;Kane M;McDonald C;Gleeson N;McLaughlin AM;Butler K;Gavin P;Keane J (2015) 'Untreated chronic tuberculous salpingitis followed by successful in vitro fertilization conception and congenital tuberculosis'. Qjm-An International Journal Of Medicine, 108 (11):899-901. [DOI] [Details]
Crealey M, Allen NM;Webb D;Bouldin A;Mc Sweeney N;Peake D;Tirupathi S;Butler K;King MD (2015) 'Sydenham's chorea: not gone but perhaps forgotten'. Archives of Disease in Childhood, . [DOI] [Details]
McAleer MA, Pohler E;Smith FJ;Wilson NJ;Cole C;MacGowan S;Koetsier JL;Godsel LM;Harmon RM;Gruber R;Crumrine D;Elias PM;McDermott M;Butler K;Broderick A;Sarig O;Sprecher E;Green KJ;McLean WH;Irvine AD (2015) 'Severe dermatitis, multiple allergies, and metabolic wasting syndrome caused by a novel mutation in the N-terminal plakin domain of desmoplakin'. Journal of Allergy and Clinical Immunology, . [DOI] [Details]
Butler KM, Gavin P;Coughlan S;Rochford A;Mc Donagh S;Cunningham O;Poulsom H;Watters SA;Klein N (2015) 'Rapid viral rebound after 4 years of suppressive therapy in a seronegative HIV-1 infected infant treated from birth'. Pediatric Infectious Disease, 34 (3):1-51. [DOI] [Details]
Leahy TR, Goode M;Lynam P;Gavin PJ;Butler KM (2014) 'HIV virological suppression influences response to the AS03-adjuvanted monovalent pandemic influenza A H1N1 vaccine in HIV-infected children'. Influenza and other Respiratory Viruses, 8 (3):360-366. [DOI] [Details]
Rao U, Piccin A;Malone A;O'Hanlon K;Breatnach F;O'Meara A;McDermott M;Butler K;O'Sullivan N;Russell J;O'Marcaigh A;Smith OP (2013) 'Utility of bronchoalveolar lavage in the diagnosis of pulmonary infection in children with haematological malignancies'. Irish Journal of Medical Science, 182 (2):177-183. [DOI] [Details]
Leahy TR, Smith OP;Bacon CL;Storey L;Lynam P;Gavin PJ;Butler KM;O'Marcaigh AS (2013) 'Does vaccine dose predict response to the monovalent pandemic H1N1 influenza a vaccine in children with acute lymphoblastic leukemia? A single-centre study'. Pediatric Blood and Cancer, 60 (10):1656-1661. [DOI] [Details]
Al-Assaf N, Maoldomhnaigh CO;Gavin P;Butler K (2013) 'Paediatric HIV: the experience in Ireland 2004-2011'. Irish Medical Journal, 106 (7):198-200. [Details]
Drew RJ, ¿¿ Maoldomhnaigh C;Gavin PJ;O' Sullivan N;Butler KM;Cafferkey M (2012) 'The impact of meningococcal polymerase chain reaction testing on laboratory confirmation of invasive meningococcal disease'. Pediatric Infectious Disease, 31 (3):316-318. [DOI] [Details]
Owens C, Mannion D;O'Marcaigh A;Waldron M;Butler K;O'Meara A (2011) 'Indications for admission, treatment and improved outcome of paediatric haematology/oncology patients admitted to a tertiary paediatric ICU'. Irish Journal of Medical Science, 180 (1):85-89. [DOI] [Details]
Lucey JM, Gavin P;Cafferkey M;Butler KM (2011) 'Pneumococcal meningitis: clinical outcomes in a pre-vaccine era at a Dublin paediatric hospital, 1999-2007'. Irish Journal of Medical Science, 180 (1):47-50. [DOI] [Details]
Ferguson W, Mayne PD;Cafferkey M;Butler K (2011) 'Lack of awareness of risk factors for primary toxoplasmosis in pregnancy'. Irish Journal of Medical Science, 180 (4):807-811. [DOI] [Details]
Ferguson W, Goode M;Walsh A;Gavin P;Butler K (2011) 'Evaluation of 4 weeks' neonatal antiretroviral prophylaxis as a component of a prevention of mother-to-child transmission program in a resource-rich setting'. Pediatric Infectious Disease, 30 (5):408-412. [DOI] [Details]
Iroh Tam PY, Menon A, Butler K.; (2010) 'A review of tuberculosis-related referrals among children in Ireland'. Irish Journal of Medical Science, 179 (2):251-254. [Details]
Judd A, Boyd KL, Stöhr W, Dunn D, Butler K, Lyall H, Sharland M, Shingadia D, Riordan A, Gibb DM. ; (2010) 'Effect of tenofovir disoproxil fumarate on risk of renal abnormality in HIV-1-infected children on antiretroviral therapy: a nested case-control study'. AIDS, 24 (4):525-534. [Details]
Coulter-Smith S, Lambert JS, Butler K, Brennan M, Cafferkey M. HIV ; (2010) 'HIV testing and treatment in the antenatal care setting'. Irish Medical Journal, 103 (1):14-17. [Details]
McMenamin MB., Jackson AD, Lambert J, Hall W, Butler K, Coulter-Smith S, McAuliffe F ; (2008) 'Obstetric management of hepatitis C-positive mothers: analysis of vertical transmission in 559 mother-infant pairs'. American Journal of Obstetrics and Gynecology, 199 (315):e1-e5. Available Online [Details]
Green H, Gibb DM, Walker AS, Pillay D, Butler K, Candeais F, Castelli ' Gattinara G, Compangnucci A, Della Negra M, de Rossi A, Feiterna-Sperling C, Giaquinto C, Harper L, Levy J, Saidi Y, wintergerst U, Paediatric European network for the Treatment of AIDS (PENTA). ; (2007) 'Lamivudine/Abacavir maintains virologic superiority over zidovudine/lamivudine and zidovudine/abacavir beyond 5 years in children'. Aids, 21 :947-955. [Details]
Lyons F, Butler K, Coulter ' Smith S and Mulcahy F.; (2006) 'National guidelines for the management of HIV-1 in pregnancy'. Irish Medical Journal, 100 :152-153. [Details]
Bolger T, O'Connell M, Menon A and Butler K. ; (2006) 'Complications associated with the Bacille Calmette Guerin vaccination in Ireland'. Archives of Disease in Childhood, 91 :594-597. [Details]
Doerholt K, Duong T, Tookey P, Butler K, Lyall H, Sharland M, Novelli V, Riordan A, Dunn D, Walker AS, Gibb DM; ; (2006) 'Collaborative HIV Paediatric Study Outcomes for human immunodeficiency virus-1-infected infants in the United kingdom and Republic of Ireland in the era of effective antiretroviral therapy'. Pediatric Infectious Disease Journal, 25 :420-426. [Details]
Martin, J; Odoom, K; Tuite, G; Dunn, G; Hopewell, N; Cooper, G; Fitzharris, C; Butler, K; Hall, WW; Minor, PD; ; (2004) 'Long-term excretion of vaccine-derived poliovirus by a healthy child'. Virology, 78 (24):13839-13847. [Details]
Nourse, C,Byrne, C,Kaufmann, M,Keane, CT,Fenelon, L,Smyth, EG,Hone, R,Butler, K; (2000) 'VRE in the Republic of Ireland: clinical significance, characteristics and molecular similarity of isolates'. Journal of Hospital Infection, 44 :288-293. [Details]
Nourse, C,Byrne, C,Murphy, H,Kaufmann, ME,Clarke, A,Butler, K; (2000) 'Eradication of vancomycin resistant Enterococcus faecium from a paediatric oncology unit and prevalence of colonization in hospitalized and community-based children'. Epidemiology and Infection, 124 :53-59. [Details]
Nourse, C,Murphy, H,Byrne, C,O'Meara, A,Breatnach, F,Kaufmann, M,Clarke, A,Butler, K; (1998) 'Control of a nosocomial outbreak of vancomycin resistant Enterococcus faecium in a paediatric oncology unit: risk factors for colonisation'. Pediatrics, 157 :20-27. [Details]
Dillon, M,Nourse, C,Dowling, F,Deasy, P,Butler, K; (1997) 'Primary meningococcal arthritis'. Pediatric Infectious Disease, 16 :331-332. [Details]
 

Conference Publications

McMenamin, MB,Jackson, AD,Lambert, J,Hall, W,Butler, K,Coulter-Smith, S,McAuliffe, FM (2008) AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY Obstetric management of hepatitis C-positive mothers: analysis of vertical transmission in 559 mother-infant pairs [DOI] [Details]
                                                                                         

Research

Research Interests

The paediatric infectious diseases and immunology group has focussed on clinical research in the areas of paediatric HIV, hepatitis C and RSV infection and is now strengthening the research effort though key collaborations with our colleagues in basic sciences.  My clinical research focuses on developing strategies to improve management of HIV infection in children as chief investigator for 'BREATHER', a global trial that compares short cycle (5 days on/2 days off) with continuous daily antiretroviral therapy for HIV infected children and young people. This study completed in June 2014 and we look forward to presenting the results in 2015.

An exciting development for the team this year has been the continued collaboration with Dr. Nigel Stevenson, Assistant Professor of Immunology at Trinity College Dublin (TCD) and his research group in the continued exploration of mechanisms by which the Hepatitis C virus can evade molecular and cellular immune responses and the role of inflammatory pathways in clearance of infection and how this may influence clearance of infection in children.  We have one MD candidate working in this area, soon to be joined by second as we embark on a wider collaboration with the European network for paediatric HCV infection ¿ PENTA HEP ¿ expanding the work to examine the role of the new directly acting antiviral agents in this pathway.

In collaboration with the National Virus Reference Laboratory, and facilitated by a ten year prospectively gathered clinical database on infants hospitalised with RSV infection, the group are now undertaking study of host factors and biomarkers predictive of RSV disease severity in infants.