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Kenneth McDonald

Clinical Professor

School Of Medicine
St Vincent's Hospital
Elm Park
Dublin 4

Tel: 012304629
Email: kenneth.mcdonald@ucd.ie

Biography

Prof. Ken McDonald developed the St Vincent's Chronic Cardiovascular Disease Management Unit incorporating the Heart Failure Unit and Blood Pressure Unit following his return from the Minnesota, US. He has overseen the growth of the Unit into an internationally recognised clinical service and translational cardiovascular research centre.

 

The Unit clinical programme provides specialist heart failure services to in excess of 5,000 patients across the spectrum of cardiovascular disease. In addition, Prof McDonald has developed the St Vincent's Screening To Prevent Heart Failure (STOP-HF) Programme in association with St. Vincent's Collaborative General Practice Group. The STOP-HF study is first-of-type, pragmatic, prospective trial which showed that natriuretic peptide-based screening and collaborative care can reduce the combined rate of left ventricular dysfunction and heart failure as well as major adverse cardiac events. This ongoing cardiovascular disease prevention study includes more than 3,000 patients

 

With established links to the School of Medicine and Medical Science and the Conway Institute at University College, Dublin, Prof McDonald's research team has focused on the natural history of left ventricular dysfunction, biomarkers of cardiovascular disease and the role of inflammation and fibrosis in the development of heart failure. He is a Co-Founder of Solvotrin and Cardiomark and is the National Clinical Lead for Heart Failure as part of the Health Services Executive Clinical Programmes.

HRB Clinical Scientist Award Recipient 

Publications

     

Peer Reviewed Journals

Watson C, James S;O'Connell E;Gallagher J;O'Reilly J;Tallon E;Baugh J;O'Connell J;O'Shea D;Ledwidge M;McDonald K (2016) 'Influence of diabetes on natriuretic peptide thresholds in screening for Stage B heart failure'. Biomarkers, :1-6. [DOI] [Details]
Murtagh G, Lyons T;O'Connell E;Ballot J;Geraghty L;Fennelly D;Gullo G;Ledwidge M;Crown J;Gallagher J;Watson C;McDonald KM;Walshe JM (2016) 'Late cardiac effects of chemotherapy in breast cancer survivors treated with adjuvant doxorubicin: 10-year follow-up'. Breast Cancer Research and Treatment, 156 (3):501-506. [DOI] [Details]
James S, Barton D;O'Connell E;Voon V;Murtagh G;Watson C;Murphy T;Prendiville B;Brennan D;Hensey M;O'Neill L;O'Hanlon R;Waterhouse D;Ledwidge M;Gallagher J;McDonald K (2015) 'Life expectancy for community-based patients with heart failure from time of diagnosis'. International Journal of Cardiology, 178 :268-274. [DOI] [Details]
Horgan SJ, Watson CJ;Glezeva N;Collier P;Neary R;Tea IJ;Corrigan N;Ledwidge M;McDonald K;Baugh JA (2015) 'Serum Amyloid P-Component Prevents Cardiac Remodeling in Hypertensive Heart Disease'. Journal of Cardiovascular Translational Research, 8 (9):554-566. [DOI] [Details]
Glezeva N, Gallagher J;Ledwidge M;O'Donoghue J;McDonald K;Chipolombwe J;Watson C (2015) 'Heart failure in sub-Saharan Africa: review of the aetiology of heart failure and the role of point-of-care biomarker diagnostics'. Tropical Medicine and International Health, 20 (5):581-588. [DOI] [Details]
Watson CJ, Horgan S;Neary R;Glezeva N;Tea I;Corrigan N;McDonald K;Ledwidge M;Baugh J (2015) 'Epigenetic Therapy for the Treatment of Hypertension-Induced Cardiac Hypertrophy and Fibrosis'. Journal of Cardiovascular Pharmacology and Therapeutics, . [DOI] [Details]
Ledwidge MT, O'Connell E;Gallagher J;Tilson L;James S;Voon V;Bermingham M;Tallon E;Watson C;O'Hanlon R;Barry M;McDonald K (2015) 'Cost-effectiveness of natriuretic peptide-based screening and collaborative care: a report from the STOP-HF (St Vincent's Screening TO Prevent Heart Failure) study'. European Journal of Heart Failure, 17 (7):672-679. [DOI] [Details]
McDonald K, Wilkinson M;Ledwidge M (2015) 'Role of Monitoring Devices in Preventing Heart Failure Admissions'. Current Heart Failure Reports, 12 (4):269-275. [DOI] [Details]
Watson CJ, Gupta SK;O'Connell E;Thum S;Glezeva N;Fendrich J;Gallagher J;Ledwidge M;Grote-Levi L;McDonald K;Thum T (2015) 'MicroRNA signatures differentiate preserved from reduced ejection fraction heart failure'. European Journal of Heart Failure, 17 (4):405-415. [DOI] [Details]
Murtagh G, O Connell J;O Connell E;Tallon E;Watson C;Gallagher J;Baugh J;Patle A;O Connell L;Griffin J;O'Hanlon R;Voon V;Ledwidge M;O Shea D;McDonald K (2015) 'Importance of risk factor management in diabetic patients and reduction in Stage B heart failure'. Qjm-An International Journal Of Medicine, 108 (4):307-314. [DOI] [Details]
Watson, C.J. and Collier, P. and Tea, I. and Neary, R. and Watson, J.A. and Robinson, C. and Phelan, D. and Ledwidge, M.T. and Mcdonald, K.M. and Mccann, A. and Sharaf, O. and Baugh, J.A. (2014) 'Hypoxia-induced epigenetic modifications are associated with cardiac tissue fibrosis and the development of a myofibroblast-like phenotype'. Human Molecular Genetics, 23 (8):2176-2188. Available Online [DOI] [Details]
Bermingham, M. and Ryder, M. and Travers, B. and Edwards, N. and Lalor, L. and Kelly, D. and Gallagher, J. and O'Hanlon, R. and McDonald, K. and Ledwidge, M. (2014) 'The St Vincent's potentially inappropriate medicines study: Development of a disease-specific consensus list and its evaluation in ambulatory heart failure care'. European Journal of Heart Failure, 16 (8):915-922. Available Online [DOI] [Details]
James, S. and Waterhouse, D. and McDonald, K. and O'Hanlon, R. (2014) 'Dilated cardiomyopathy and progressive familial intrahepatic cholestasis'. BMJ Case Reports, . Available Online [DOI] [Details]
Bermingham, M. and Shanahan, M.K. and O'Connell, E. and Dawkins, I. and Miwa, S. and O'Hanlon, R. and Gilmer, J. and McDonald, K. and Ledwidge, M. (2014) 'Aspirin use in heart failure is low-dose therapy associated with mortality and morbidity benefits in a large community population?'. Circulation: Heart Failure, 7 (2):243-250. Available Online [DOI] [Details]
Watson, C.J. and Phelan, D. and Collier, P. and Horgan, S. and Glezeva, N. and Cooke, G. and Xu, M. and Ledwidge, M. and Mcdonald, K. and Baugh, J.A. (2014) 'Extracellular matrix sub-types and mechanical stretch impact human cardiac fibroblast responses to transforming growth factor beta'. Connective Tissue Research, 55 (3):248-256. Available Online [DOI] [Details]
Glezeva, N. and Collier, P. and Voon, V. and Ledwidge, M. and McDonald, K. and Watson, C. and Baugh, J. (2013) 'Attenuation of monocyte chemotaxis-a novel anti-inflammatory mechanism of action for the cardio-protective hormone B-type natriuretic peptide'. Journal of Cardiovascular Translational Research, 6 (4):545-557. Available Online [DOI] [Details]
Ledwidge, M.T. and O'Hanlon, R. and Lalor, L. and Travers, B. and Edwards, N. and Kelly, D. and Voon, V. and McDonald, K.M. (2013) 'Can individualized weight monitoring using the HeartPhone algorithm improve sensitivity for clinical deterioration of heart failure?'. European journal of heart failure, 15 (4):447-455. Available Online [DOI] [Details]
Dahlström, U. and Mcdonald, K. and Maisel, A. (2013) 'Integration of B-Type natriuretic peptide in heart failure outpatient programs'. Congestive Heart Failure, 14 (4). Available Online [DOI] [Details]
Mcdonagh, T.A. and Mcdonald, K. and Maisel, A.S. (2013) 'Screening for asymptomatic left ventricular dysfunction using B-type natriuretic peptide'. Congestive Heart Failure, 14 (4). Available Online [DOI] [Details]
Ledwidge, M. and Gallagher, J. and Conlon, C. and Tallon, E. and O'Connell, E. and Dawkins, I. and Watson, C. and O'Hanlon, R. and Bermingham, M. and Patle, A. and Badabhagni, M.R. and Murtagh, G. and Voon, V. and Tilson, L. and Barry, M. and McDonald, L. and Maurer, B. and McDonald, K. (2013) 'Natriuretic peptide-based screening and collaborative care for heart failure: The STOP-HF randomized trial'. JAMA - Journal of the American Medical Association, 310 (1):66-74. Available Online [DOI] [Details]
Jan, A. and Dawkins, I. and Murphy, N. and Collier, P. and Baugh, J. and Ledwidge, M. and McDonald, K. and Watson, C.J. (2013) 'Associates of an elevated natriuretic peptide level in stable heart failure patients: Implications for targeted management'. The Scientific World Journal, 2013 . Available Online [DOI] [Details]
Ledwidge, M.T. and O'Hanlon, R. and Lalor, L. and Travers, B. and Edwards, N. and Kelly, D. and Voon, V. and McDonald, K.M. (2013) 'Can individualized weight monitoring using the HeartPhone algorithm improve sensitivity for clinical deterioration of heart failure?'. European journal of heart failure, 15 (4):447-455. Available Online [DOI] [Details]
Ledwidge, M. and Gallagher, J. and Conlon, C. and Tallon, E. and O'Connell, E. and Dawkins, I. and Watson, C. and O'Hanlon, R. and Bermingham, M. and Patle, A. and Badabhagni, M.R. and Murtagh, G. and Voon, V. and Tilson, L. and Barry, M. and McDonald, L. and Maurer, B. and McDonald, K. (2013) 'Natriuretic peptide-based screening and collaborative care for heart failure: The STOP-HF randomized trial'. JAMA - Journal of the American Medical Association, 310 (1):66-74. Available Online [DOI] [Details]
Phelan, D. and Watson, C. and Martos, R. and Collier, P. and Patle, A. and Donnelly, S. and Ledwidge, M. and Baugh, J. and McDonald, K. (2012) 'Modest Elevation in BNP in Asymptomatic Hypertensive Patients Reflects Sub-Clinical Cardiac Remodeling, Inflammation and Extracellular Matrix Changes'. PLoS ONE, 7 (11). Available Online [DOI] [Details]
Collier, P. and Watson, C.J. and van Es, M.H. and Phelan, D. and McGorrian, C. and Tolan, M. and Ledwidge, M.T. and McDonald, K.M. and Baugh, J.A. (2012) 'Getting to the heart of cardiac remodeling; how collagen subtypes may contribute to phenotype'. Journal of Molecular and Cellular Cardiology, 52 (1):148-153. Available Online [DOI] [Details]
Collier, P. and McDonald, K.M. (2012) 'The Role of Renin Angiotensin System Intervention in Stage B Heart Failure'. Heart Failure Clinics, 8 (2):225-236. Available Online [DOI] [Details]
McDonald, K. and Dahlström, U. (2012) 'Natriuretic peptides - addressing the dilemma of heart failure management'. Interventional Cardiology (London), 7 (2):104-107. Available Online [Details]
Abulhul, E. and McDonald, K. and Martos, R. and Phelan, D. and Spiers, J.P. and Hennessy, M. and Baugh, J. and Watson, C. and O'Loughlin, C. and Ledwidge, M. (2012) 'Long-Term Statin Therapy in Patients With Systolic Heart Failure and Normal Cholesterol: Effects on Elevated Serum Markers of Collagen Turnover, Inflammation, and B-Type Natriuretic Peptide'. Clinical Therapeutics, 34 (1):91-100. Available Online [DOI] [Details]
Murtagh, G. and Dawkins, I.R. and O'Connell, R. and Badabhagni, M. and Patel, A. and Tallon, E. and O'Hanlon, R. and Ledwidge, M.T. and McDonald, K.M. (2012) 'Screening to prevent heart failure (STOP-HF): Expanding the focus beyond asymptomatic left ventricular systolic dysfunction'. European Journal of Heart Failure, 14 (5):480-486. Available Online [DOI] [Details]
Watson, C.J. and Phelan, D. and Xu, M. and Collier, P. and Neary, R. and Smolenski, A. and Ledwidge, M. and McDonald, K. and Baugh, J. (2012) 'Mechanical stretch up-regulates the B-type natriuretic peptide system in human cardiac fibroblasts: A possible defense against transforming growth factor-β mediated fibrosis'. Fibrogenesis and Tissue Repair, 5 (1). Available Online [DOI] [Details]
Collier, P. and Ledwidge, M. and McDonald, K. (2012) 'Diagnostics and therapeutic interventions in myocardial interstitial disease, a previously neglected pathology'. QJM, 105 (8):721-724. Available Online [DOI] [Details]
Collier, P. and Watson, C.J. and Waterhouse, D.F. and Dawkins, I.R. and Patle, A.K. and Horgan, S. and Conlon, C.M. and O'Hanlon, R. and Baugh, J.A. and Ledwidge, M.T. and McDonald, K. (2012) 'Progression of left atrial volume index in a population at risk for heart failure: A substudy of the STOP-HF (St Vincent's Screening to Prevent Heart Failure) trial'. European Journal of Heart Failure, 14 (9):957-964. Available Online [DOI] [Details]
Bermingham, M. and McDonald, K. and Ledwidge, M. (2011) 'The authors respond:'. Clinical Therapeutics, 33 (12):2090. Available Online [DOI] [Details]
Watson, C.J. and Ledwidge, M.T. and Phelan, D. and Collier, P. and Byrne, J.C. and Dunn, M.J. and McDonald, K.M. and Baugh, J.A. (2011) 'Proteomic analysis of coronary sinus serum reveals leucine-rich α2-glycoprotein as a novel biomarker of ventricular dysfunction and heart failure'. Circulation: Heart Failure, 4 (2):188-197. Available Online [DOI] [Details]
McDonagh, T.A. and Blue, L. and Clark, A.L. and Dahlström, U. and Ekman, I. and Lainscak, M. and McDonald, K. and Ryder, M. and Ströxmberg, A. and Jaarsma, T. (2011) 'European Society of Cardiology Heart Failure Association Standards for delivering heart failure care'. European Journal of Heart Failure, 13 (3):235-241. Available Online [DOI] [Details]
Conlon, C.M. and Dawkins, I. and O'Loughlin, C. and Gibson, D. and Kelleher, C.C. and Ledwidge, M. and McDonald, K. (2011) 'B-type natriuretic peptide measurement in primary care; Magnitude of associations with cardiovascular risk factors and their therapies. Observations from the STOP-HF (St. Vincent's Screening to Prevent Heart Failure) study'. Clinical Chemistry and Laboratory Medicine, 49 (4):719-728. Available Online [DOI] [Details]
Jan, A. and Murphy, N.F. and O'Loughlin, C. and Ledwidge, M. and McDonald, K. (2011) 'Profiling B-type natriuretic peptide in a stable heart failure population: A valuable adjunct to care'. Irish Journal of Medical Science, 180 (2):355-362. Available Online [DOI] [Details]
Arnous, S. and Murphy, N.F. and Pyne-Daly, P. and Nawoor, Z. and Keane, D. and Ledwidge, M. and McDonald, K. (2011) 'Clinical and psychological impact of prophylactic implantable cardioverter-defibrillators in a community heart failure population'. Irish Journal of Medical Science, 180 (2):369-374. Available Online [DOI] [Details]
Bermingham, M. and Ocallaghan, E. and Dawkins, I. and Miwa, S. and Samsudin, S. and McDonald, K. and Ledwidge, M. (2011) 'Are beta2-agonists responsible for increased mortality in heart failure?'. European Journal of Heart Failure, 13 (8):885-891. Available Online [DOI] [Details]
Arnous, S. and Killeen, R.P. and Martos, R. and Quinn, M. and McDonald, K. and Dodd, J.D. (2011) 'Quantification of mitral regurgitation on cardiac computed tomography: Comparison with qualitative and quantitative echocardiographic parameters'. Journal of Computer Assisted Tomography, 35 (5):625-630. Available Online [DOI] [Details]
Bermingham, M. and Hayden, J. and Dawkins, I. and Miwa, S. and Gibson, D. and McDonald, K. and Ledwidge, M. (2011) 'Prospective analysis of ldl-c goal achievement and self-reported medication adherence among statin users in primary care'. Clinical Therapeutics, 33 (9):1180-1189. Available Online [DOI] [Details]
Collier, P. and Watson, C.J. and Voon, V. and Phelan, D. and Jan, A. and Mak, G. and Martos, R. and Baugh, J.A. and Ledwidge, M.T. and McDonald, K.M. (2011) 'Can emerging biomarkers of myocardial remodelling identify asymptomatic hypertensive patients at risk for diastolic dysfunction and diastolic heart failure?'. European Journal of Heart Failure, 13 (10):1087-1095. Available Online [DOI] [Details]
Ryder, M. and Beattie, J.M. and O'Hanlon, R. and McDonald, K. (2011) 'Multidsciplinary heart failure management and end of life care'. Current Opinion in Supportive and Palliative Care, 5 (4):317-321. Available Online [DOI] [Details]
McDonald, K. and Dahlström, U. (2011) 'Natriuretic peptides - Addressing the dilemma of heart failure management'. European Cardiology, 7 (2):104-107. Available Online [Details]
McDonald K.; (2010) 'Disease management programs for heart failure'. Current treatment options in cardiovascular medicine, . [Details]
McDonald K.; (2010) 'Monitoring fluid status at the outpatient level: the need for more precision'. Congestive heart failure (Greenwich, Conn.), . [Details]
 

Conference Publications

Martos, R., Baugh, J., Ledwidge, M., O'Loughlin, C., Conlon, C., Donnelly, S. McDonald, K.; (2006) Elevated plasma markers of matrix metalloproteinases type 2 and 9 are independent predictors of diastolic heart failure Heart Failure Congress [Details]
Martos, R., Baugh, J., Ledwidge, M., O'Loughlin, C., Donnelly, S. McDonald, K.; (2005) Diastolic Heart failure is associated with elevated serum markers of collagen turnover Heart Failure Congress [Details]
                                                                                         

Research

 

Research Projects

Sponsor : Health Research Board (HRB)
Title : Development of The STOP-HF network for community based prevention of Heart Failure
Start Date / End Date : 07-DEC-15 / 30-JUN-17
Sponsor : Irish Cardiac Society (ICS)
Title : Boston Scientific Research Bursary
Start Date / End Date : 01-SEP-10 / 01-SEP-12
Sponsor : Health Research Board (HRB)
Title : Home telemonitoring in a high risk heart failure population
Start Date / End Date : 15-DEC-08 / 15-DEC-10
Sponsor : EC Framework (FP7)
Title : MEDIA- The MEtabolic Road to DIastolic Heart Failure
Start Date / End Date : 01-JAN-11 / 31-DEC-15
Sponsor : Health Research Board (HRB)
Title : Obstructive Sleep Apnoea Syndrome As an Important Cause of Non-dipping Hypertension - Prevalence and Mechanistic Insights
Start Date / End Date : 01-JAN-13 / 30-JUN-16
Sponsor : Health Research Board (HRB)
Title : Natural History of Diabetic Cardiomyopathy
Start Date / End Date : 01-DEC-12 / 30-NOV-17
Sponsor : Health Research Board (HRB)
Title : Immunomodulatory-matrix metalloproteinase (MMP) inhibition with tetracyclines in obesity, diabetes and asymptomatic left ventricular diastolic dysfunction: impact on MMP-9 levels and cardiovascular structure and function
Start Date / End Date : 01-NOV-12 / 31-DEC-16
Sponsor : EC Framework (FP7)
Title : HOMAGE
Start Date / End Date : 01-FEB-13 / 31-JAN-19
Sponsor : EC Framework (FP7)
Title : Targeting cardiac fibrosis for heart failure treatment (FIBRO-TARGETS)
Start Date / End Date : 01-SEP-13 / 31-AUG-17
Sponsor : Enterprise Ireland (EI)
Boston Scientific
Cardiomark Ltd
ResMed Sensor Technologies Ltd
Title : Development of scalable new model(s) focussed on care coordination and care provision for medically complex, co-morbid chronic disease patient segments focussing on Heart Failure (`HF¿)
Start Date / End Date : 01-JAN-14 / 01-NOV-16
 

Current Postgraduate Students

Grace O Carroll, Medicine (MD)   -   Thesis Supervisor
Stephanie James, Medicine (MD)   -   Thesis Supervisor