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Niall Tubridy

Clinical Full Professor

School of Medicine
Department of Neurology
St. Vincent's University Hospital
Elm Park
Dublin 4

Tel: 353 1 221 3830
Email: niall.tubridy@ucd.ie

Biography

I qualified from RCSI in 1991 and worked in Dublin before moving to London in 1994. I did both clinical and research work in the National Hospital for Neurology and Neurosurgery at Queen Square among other hospitals in London and then moved to the Pitie Salpetriere Hospital in Paris for a year. I then moved to the Royal Melbourne Hospital as a consultant before returning to St Vincent¿s in 2004.

The Department of Neurology at St Vincent¿s University Hospital has significantly expanded in recent years and we are now running an extensive research program in multiple sclerosis (MS) and dystonia.

The Department sees over 12,000 patients annually, runs three public clinics daily and over 2000 patients are treated as Day Cases. We also have seen a huge increase in neurology in-patient consults (over 2000 per year).

The Department runs specialist clinics in multiple sclerosis, dystonia and Parkinson¿s disease. We also supervise a GP led Migraine Clinic.

We have published extensively in the last 10-15 years and are currently involved in more than 10 clinical trials in MS.

 

We encourage student involvement and run neurology teaching weeks twice a year for all UCD medical students. These have been very successful and audited every time to monitor changing needs.

We have produced a series of neurology teaching videos which went live via YouTube and to date the videos have been visited over 1 million times and accessed from over 300 countries throughout the world.

Professional

Honours and Awards

Year: 2006.
Title: Clinical Teacher of the Year
Year: 2011.
Title: Clinical Teacher of the Year
Year: 2012.
Title: Clinical Teacher of the Year
Year: 2006.
Title: HSE Innovation Award Winner for Neurolink
Year: 2007.
Title: HSE Regional Award for Innovation: Neurology, changing the way we practice
Year: 2008.
Title: HSE National Award for Innovation: Neurology, changing the way we practice
Year: 2010.
Title: Irish Times Business Innovation Award for Neurolink
Year: 2011.
Title: Innovation in Healthcare Delivery Finalist

Associations

Association: Education and Research Centre, St. Vincent's Hospital, Function/Role: Member
Association: Irish Neurological Association, Function/Role: Member
Association: Association of British Neurologists, Function/Role: Member
Association: Royal College of Physicians of Ireland, Function/Role: Fellow and Former Council Member
Association: Royal Australian College of Physicians, Function/Role: Fellow
     

Conference Contributions

3. Lonergan R, Kinsella K, Fitzpatrick P, Duggan M, Jordan S, Brady Jennifer, Murray B, McKenna M, Hutchinson M, Tubridy N. ; (2009) Epidemiology of Multiple Sclerosis (MS) in Ireland: prevalence in Dublin, Wexford and Donegal in relation to vitamin D status. [Oral Presentation], Irish Neurological Association meeting, Dublin , 01-MAY-09 - 01-MAY-09.

Committees

Committee : Summer Student Research Awards Committee, UCD
Committee : Council of the Royal College of Physicians of Ireland
         

Journals Edited

Multiple Sclerosis: Reviewer.
European Journal Of Neurology: Reviewer.
Irish Journal Of Medical Science: Reviewer.
Irish Medical Journal: Reviewer.
Cns Drugs: Reviewer.
Journal Of Neurology: Reviewer.
Medicine: Reviewer.

Other Activities

Invented 'Neurolink': a web based service for neurology referrals. Subsequently adapted throughout HSE for referrals esp in cancer.

 

Developed an intranet web based service for in hospital consultations

 

Developed web based YouTube videos with over 1 million hits to date

Publications

 

Book Chapters

Kilpatrick, TJ; Tubridy, N (2004) 'Molecular mechanisms regulating motor neuron development and degeneration' In: Eisen, A (eds). Clinical Neurophysiology of Motor Neuron Disease. Unknown: Elsevier. [Details]
 

Peer Reviewed Journals

Kiiski HS, N¿¿ Riada S;Lalor EC;Gon¿¿alves NR;Nolan H;Whelan R;Lonergan R;Kelly S;O'Brien MC;Kinsella K;Bramham J;Burke T;¿¿ Donnchadha S;Hutchinson M;Tubridy N;Reilly RB (2016) 'Delayed P100-Like Latencies in Multiple Sclerosis: A Preliminary Investigation Using Visual Evoked Spread Spectrum Analysis'. PLoS ONE, 11 (1). [DOI] [Details]
McNulty JP, Lonergan R;Bannigan J;O'Laoide R;Rainford LA;Tubridy N (2016) 'Visualisation of the medial longitudinal fasciculus using fibre tractography in multiple sclerosis patients with internuclear ophthalmoplegia'. Irish Journal of Medical Science, 185 (2):393-402. [DOI] [Details]
Lonergan R, Kinsella K, Fitzpatrick P, Duggan M, Jordan S, Bradley D, Hutchinson M, Tubridy N (2015) 'Unmet needs of multiple sclerosis patients in the community'. Multiple Sclerosis and Related Disorders, 4 (2):144-150. [DOI] [Details]
Greene BR, Healy M;Rutledge S;Caulfield B;Tubridy N (2015) 'Quantitative assessment of multiple sclerosis using inertial sensors and the TUG test'. Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference, 2014 :2977-2980. [DOI] [Details]
O'Connell K, Langdon D;Tubridy N;Hutchinson M;McGuigan C (2015) 'A preliminary validation of the brief international cognitive assessment for multiple sclerosis (BICAMS) tool in an Irish population with multiple sclerosis (MS)'. Multiple Sclerosis and Related Disorders, 4 (6):521-525. [DOI] [Details]
Rutledge S, Chalissery A;O'Connor R;Mahon S;Connolly S;Farrell M;Crowley P;MacSweeney F;Tubridy N (2015) 'Anti-NMDA-receptor antibody-mediated cortical blindness: a case report'. Qjm-An International Journal Of Medicine, . [DOI] [Details]
Broderick N, Farrell C;Tubridy N (2015) 'Should we call the neurologist? The value and cost of a growing neurology consultation service'. Irish Journal of Medical Science, . [DOI] [Details]
McNulty JP, Lonergan R;Brennan PC;Evanoff MG;O'Laoide R;Ryan JT;Tubridy N (2015) 'Diagnostic Efficacy of Conventional MRI Pulse Sequences in the Detection of Lesions Causing Internuclear Ophthalmoplegia in Multiple Sclerosis Patients'. Clinical Neuroradiology, 25 (3):233-239. [DOI] [Details]
O'Connell K, Kelly SB;Fogarty E;Duggan M;Buckley L;Hutchinson M;McGuigan C;Tubridy N (2015) 'Economic costs associated with an MS relapse'. Multiple Sclerosis and Related Disorders, 3 (6):678-683. [DOI] [Details]
Elamin M, Lonergan R;Killeen RP;O'Riordan S;Tubridy N;McGuigan C (2015) 'Posterior cortical and white matter changes on MRI in anti-AMPA receptor antibody encephalitis'. Neurology: neuroimmunology & neuroinflammation, 2 (4). [DOI] [Details]
Fogarty E, Walsh C;McGuigan C;Tubridy N;Barry M (2014) 'Direct and indirect economic consequences of multiple sclerosis in Ireland'. Applied Health Economics and Health Policy, 12 (6):635-645. [DOI] [Details]
O'Toole O, Murphy O;O'Dwyer J;Lonergan R;Keogh B;Tubridy N;Lynch T;Farrell M (2014) 'Paraneoplastic dentate ganglionopathy: clinical and neuroimmunologic studies'. Clinical Neuropathology, 34 (1):34-39. [DOI] [Details]
Ziemssen T, Bajenaru OA;Carr¿¿ A;de Klippel N;de S¿¿ JC;Edland A;Frederiksen JL;Heinzlef O;Karageorgiou KE;Lander Delgado RH;Landtblom AM;Mac¿¿as Islas MA;Tubridy N;Gilgun-Sherki Y (2014) 'A 2-year observational study of patients with relapsing-remitting multiple sclerosis converting to glatiramer acetate from other disease-modifying therapies: the COPTIMIZE trial'. Journal of Neurology, 261 (11):2101-2111. [DOI] [Details]
O'Connell K, Kelly S, Kinsella K, Jordan S, Kenny O, Murphy D, Heffernan E, O'Laoide R, O'Shea D, McKenna C, Cassidy L, Fletcher J, Walsh C, Brady J, McGuigan C, Tubridy N, Hutchinson M (2013) 'Dose-related effects of vitamin D on immune responses in patients with clinically isolated syndrome and healthy control participants: study protocol for an exploratory randomized double- blind placebo-controlled trial'. Trials, 14 . [DOI] [Details]
Murphy R, Tubridy N;Kevelighan H;O'Riordan S (2013) 'Parkinson's disease: how is employment affected?'. Irish Journal of Medical Science, 182 (3):415-419. [DOI] [Details]
Fletcher J, Hutchinson M, Tubridy N (2013) 'Response to comment on the article by Allen et al. 'A pilot study of the immunological effects of high-dose vitamin D in healthy volunteers''. Multiple Sclerosis, 19 (4). [DOI] [Details]
ÿ Donnchadha S, Burke T, Bramham J, O'Brien MC, Whelan R, Reilly R, Kiiski H, Lonergan R, Kinsella K, Kelly S, McGuigan C, Hutchinson M, Tubridy N (2013) 'Symptom overlap in anxiety and multiple sclerosis'. Multiple Sclerosis, 19 (10):1349-1354. [DOI] [Details]
Kelly S, Kinsella K, Duggan M, Tubridy N, McGuigan C, Hutchinson M (2012) 'A proposed modification to the McDonald 2010 criteria for the diagnosis of primary progressive multiple sclerosis'. Multiple Sclerosis, . [DOI] [Details]
Kiiski, H,Reilly, RB,Lonergan, R,Kelly, S,O'Brien, MC,Kinsella, K,Bramham, J,Burke, T,Donnchadha, SO,Nolan, H,Hutchinson, M,Tubridy, N,Whelan, R (2012) 'Only Low Frequency Event-Related EEG Activity Is Compromised in Multiple Sclerosis: Insights from an Independent Component Clustering Analysis'. PLoS ONE, 7 . [DOI] [Details]
Lonergan, R,Kinsella, K,Fitzpatrick, P,Brady, J,Murray, B,Dunne, C,Hagan, R,Duggan, M,Jordan, S,McKenna, M,Hutchinson, M,Tubridy, N; (2011) 'Multiple sclerosis prevalence in Ireland: relationship to vitamin D status and HLA genotype'. Neurology, 82 :317-322. [DOI] [Details]
International Multiple Sclerosis Genetics Consortium; Wellcome Trust Case Control Consortium (2011) 'Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis'. Nature, 476 (7359):214-219. [Details]
Kiiski, H,Reilly, RB,Lonergan, R,Kelly, S,O'Brien, M,Kinsella, K,Bramham, J,Burke, T,O'Donnchadha, S,Nolan, H,Hutchinson, M,Tubridy, N,Whelan, R; (2011) 'Change in PASAT performance correlates with change in P3 ERP amplitude over a 12-month period in multiple sclerosis patients'. Journal of the Neurological Sciences, 305 :45-52. [DOI] [Details]
O'Brien M, Lonergan R, Costelloe L, O'Rourke K, Fletcher JM, Kinsella K, Sweeney C, Antonelli G, Mills KH, O'Farrelly C, Hutchinson M, Tubridy N.; (2010) 'OAS1: a multiple sclerosis susceptibility gene that influences disease severity'. Neurology, . [Details]
Kiiski H, Whelan R, Lonergan R, Nolan H, Kinsella K, Hutchinson M, Tubridy N, Reilly RB.; (2010) 'Preliminary evidence for correlation between PASAT performance and P3a and P3b amplitudes in progressive multiple sclerosis'. European Journal of Neurology, . [Details]
Zinchuk AV, Flanagan EP, Tubridy NJ, Miller WA, McCullough LD.; (2010) 'Attitudes of US medical trainees towards neurology education: Neurophobia - a global issue'. BMC medical education, . [Details]
Whelan R, Lonergan R, Kiiski H, Nolan H, Kinsella K, Hutchinson M, Tubridy N, Reilly RB.; (2010) 'Impaired information processing speed and attention allocation in multiple sclerosis patients versus controls: a high-density EEG study'. Journal of the Neurological Sciences, . [Details]
Whelan R, Lonergan R, Kiiski H, Nolan H, Kinsella K, Bramham J, O'Brien M, Reilly RB, Hutchinson M, Tubridy N.; (2010) 'A high-density ERP study reveals latency, amplitude, and topographical differences in multiple sclerosis patients versus controls'. Clinical Neurophysiology, . [Details]
Ali E, Chaila E, Hutchinson M, Tubridy N.; (2010) 'The 'hidden work' of a hospital neurologist: 1000 consults later'. European Journal of Neurology, . [Details]
Lonergan R, Kinsella K, Duggan M, Jordan S, Hutchinson M, Tubridy N.; (2009) 'Discontinuing disease-modifying therapy in progressive multiple sclerosis: can we stop what we have started?'. MULT SCLER, . [Details]
Fletcher JM, Lonergan R, Costelloe L, Kinsella K, Moran B, O'Farrelly C, Tubridy N, Mills KH.; (2009) 'CD39+Foxp3+ regulatory T Cells suppress pathogenic Th17 cells and are impaired in multiple sclerosis'. J IMMUNOL, . [Details]
Molloy A, Cawley N, Ali E, Connolly S, Tubridy N, Hutchinson M.; (2009) 'A pernicious leucoencephalopathy'. Irish Medical Journal, . [Details]
O'Connor P, Filippi M, Arnason B, Comi G, Cook S, Goodin D, Hartung HP, Jeffery D, Kappos L, Boateng F, Filippov V, Groth M, Knappertz V, Kraus C, Sandbrink R, Pohl C, Bogumil T; BEYOND Study Group, O'Connor P, Filippi M, Arnason B, Cook S, Goodin D, Harung HP, Kappos L, Jeffery D, Comi G.; (2009) '250 microg or 500 microg interferon beta-1b versus 20 mg glatiramer acetate in relapsing-remitting multiple sclerosis: a prospective, randomised, multicentre study'. Lancet, . [Details]
Lonergan RM, Carr MJ, De Gascun CF, Costelloe LF, Waters A, Coughlan S, Duggan M, Doyle K, Jordan S, Hutchinson MW, Hall WW, Tubridy NJ.; (2009) 'Reactivation of BK polyomavirus in patients with multiple sclerosis receiving natalizumab therapy'. Journal of Neurovirology, . [Details]
Labrum RW, Rajakulendran S, Graves TD, Eunson LH, Bevan R, Sweeney MG, Hammans SR, Tubridy N, Britton T, Carr LJ, Ostergaard JR, Kennedy CR, Al-Memar A, Kullmann DM, Schorge S, Temple K, Davis MB, Hanna MG.; (2009) 'Large scale calcium channel gene rearrangements in episodic ataxia and hemiplegic migraine: implications for diagnostic testing'. Journal of Medical Genetics, . [Details]
The Australia and New Zealand Multiple Sclerosis Genetics Consortium (2009) 'Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20'. Nature Genetics, 41 (7):824-828. [Details]
 

Conference Publications

Ó Donnchadha, S., Burke, T., Bramham, J., O'Brien, M.C., Whelan, R., Reilly, R., Lonergan, R., Kinsella, K., Kiiski, H., McGuigan, C., Hutchinson, M. & Tubridy, N. (2012) Symptom overlap in anxiety and multiple sclerosis: on the need for caution European Committee for Treatment and Research in Multiple Sclerosis Lyon, France, [Details]
Ó Donnchadha, S., Burke, T., Bramham, J., O'Brien, M.C., Whelan, R., Reilly, R., Lonergan, R., Kinsella, K., Kiiski, H., McGuigan, C., Hutchinson, M. & Tubridy, N. (2012) Usefulness of the Beck Anxiety Inventory (BAI) for the assessment of anxiety in multiple sclerosis 48th Meeting Irish Neurological Association Western Gateway Building, University College Cork, , 10-MAY-12 - 11-MAY-12 [Details]
McNulty JP, Lonergan R, Bannigan J, Brennan PC, Hutchinson M, O'Laoide R, Tubridy N; (2011) Fiber Tractography of the Medial Longitudinal Fasciculus in Multiple Sclerosis subjects with Internuclear Ophthalmoplegia Irish Magnetic Resonance Imaging Meeting Dublin, Ireland, , 29-JAN-11 - 29-JAN-11 Available Online [Details]
McNulty JP, Lonergan R, Bannigan J, Brennan PC, Hutchinson M, O'Laoide R, Tubridy N; (2011) Fiber Tractography of the Medial Longitudinal Fasciculus in Multiple Sclerosis subjects with Internuclear Ophthalmoplegia Irish Institute of Radiography and Radiation Therapy Annual Conference Dublin, Ireland, , 07-OCT-11 - 08-OCT-11 Available Online [Details]
Ó Donnchadha S., Bramham J., Burke T., O¿Brien M.C., Whelan R., Reilly R., Lonergan R., Kinsella K., Kiiski H., McGuigan C., Hutchinson M., & Tubridy N. ; (2011) A longitudinal study of processing speed and working memory in multiple sclerosis as measured by the Paced Auditory Serial Addition Test (PASAT) Irish Neurological Association Meeting [Details]
Lonergan R, Fitzpatrick P, Kinsella K, Duggan M, Jordan S, Bradley D, Hutchinson M, Tubridy N (2011) Unmet needs of MS patients ECTRIMS meeting, Geneva Geneva, , 11-OCT-11 - 11-OCT-11 [Details]
Ó Donnchadha S., Bramham J., Burke T., O¿Brien M.C., Whelan R., Reilly R., Lonergan R., Kinsella K., Kiiski H., Hutchinson M., & Tubridy N. ; (2010) A longitudinal analysis of cognitive functioning in multiple sclerosis Psychological Society of Ireland Annual Conferenc [Details]
Lonergan, R and Whelan, R and Kiiski, H and Kinsella, K and Nolan, H and Reilly, RB and Hutchinson, M and Tubridy, N (2009) Multiple sclerosis patients with low PASAT scores have delayed P3 latency EUROPEAN JOURNAL OF NEUROLOGY , pp.261-261 [Details]
McNulty J, Lonergan R, Brennan PC, Costelloe L, O¿Laoide R, Tubridy N ; (2008) Diffusion Tensor Imaging of the Medial Longitudinal Fasciculus in MS patients with Internuclear Opthalmoplegia Association of British Neurologists joint Spring Meeting with the British Society for Clinical Neurophysiology Dublin, Ireland, , 26-MAR-08 - 28-MAR-08 [Details]
McNulty J, Lonergan R, Brennan PC, Costelloe L, O¿Laoide R, Tubridy N ; (2008) Diffusion Tensor Imaging of the Medial Longitudinal Fasciculus in MS patients with Internuclear Opthalmoplegia 44th Annual Meeting of the Irish Neurological Association Association Cork, Ireland, , 08-MAY-08 - 09-MAY-08 [Details]
McNulty J, Lonergan R, Brennan PC, Costelloe L, O¿Laoide R, Tubridy N ; (2008) Apparent Diffusion Coefficient demonstrates greater sensitivity to Multiple Sclerosis lesions than Fractional Anisotropy and conventional Magnetic Resonance Imaging World Congress for Treatment and Research in Multiple Sclerosis Montreal, Canada, , 17-SEP-08 - 20-SEP-08 [Details]
Lonergan R, McNulty J, Brennan PC, Costelloe L, Hutchinson M, O¿Laoide R, Tubridy N ; (2008) Apparent Diffusion Coefficient demonstrates greater sensitivity to Multiple Sclerosis lesions 8th Annual UCD Conway Festival of Research Dublin, Ireland, , 09-OCT-08 [Details]
                       

Abstract

Kinsella, K,Kelly, SB,DeGascun, CF,Carr, M,Duggan, M,Hutchinson, M,Tubridy, N,McGuigan, C (2012) THE SENSITIVITY OF JC VIRUS DNA DETECTION VS JC VIRUS ANTIBODY TESTING IN A NATALIZUMAB-TREATED GROUP OF RELAPSING MS PATIENTS. Abstract [DOI] [Details]
Lonergan, R,Kinsella, K,Fitzpatrick, P,Duggan, M,Jordan, S,Bradley, D,Hutchinson, M,Tubridy, N (2012) Factors relating to unmet needs of Irish MS patients. Abstract [Details]
McEneaney, F,Kelly, S,Jackson, J,Hutchinson, M,Tubridy, N,McGuigan, C (2012) Unmatched CSF oligoclonal bands: can we differentiate between demyelinating disorders and other causes?. Abstract [Details]
Lonergan, R,Kinsella, K,Fitzpatrick, P,Duggan, M,Jordan, S,Bradley, D,Hutchinson, M,Tubridy, N (2011) UNMET NEEDS OF IRISH MS PATIENTS. Abstract [Details]
Murphy, R,Tubridy, N (2011) YOUNG PEOPLE WITH PARKINSON'S DISEASE- THE EFFECT OF THE CONDITION ON EMPLOYMENT. Abstract [Details]
                                                               

Research

Research Interests

My main area of research has been in multiple sclerosis. I have over 110 peer reviewed publications and over 200 abstract publications/presentations. I am interested in most areas of neurology but particularly clinical areas and in exploring new ways to teach the subject (see below). I am also interested in developing innovative methods to improve clinical practice such a 'Neurolink' which I developed in 2006.

UCD Medicine Research Centres: Bioinformatics, Rare Diseases

UCD Medicine Research Group: Neurology 

Research Projects

Sponsor : University College Dublin (UCD)
Title : Neurology Research Nurses
Start Date / End Date : 01-JUN-13 / 31-JAN-18

Recent Postgraduates

MD Theses 

 

2005-2007: Dr. Lisa Costelloe, University College Dublin

MS: clinical, genetic and immunological aspects

 

2007-2009: Dr. Roisin Lonergan, University College Dublin

Vitamin D status for people with MS in Ireland

 

2010-2012: Dr. Siobhan Kelly, University College Dublin

Multiple sclerosis- epidemiological studies

 

2012-2014: Dr. Karen O¿Connell, University College Dublin

Multiple sclerosis- incidence in Ireland

 

2014-Present: Dr. N. McNicholas

MS- cognitive and therapeutic aspects

 

2011-2012: Melissa Jones, University College Dublin

BSc Thesis: Epidemiology of Myasthenia Gravis in Ireland¿

 

Teaching

Teaching Philosophy

There is a progressive teaching policy for undergraduates and postgraduates in the Neurosciences and throughout my career I have maintained my goal of 'demystifyng' neurology to successive generations of medical students.
 

Enhancement of Teaching

Biannual Neurology Teaching weeks for undergraduates (2010-present)

Review and Enhancement of Curriculum

Ran and supervised Membership Examinations since 2005-2013. Director of Examinations, Royal College of Physicians in Ireland, 2008 to 2013
 

Innovation & Leadership

I produced a series of teaching videos demonstrating neurological examination techniques and interesting cases. These were put up on YouTube in 2013. So far, the videos have had over 1 million visits viewed in over 300 countries worldwide. I have also developed a neurology teaching manual for attending students.

Collaborators

Internal Collaborators

Clinical colleagues(both neurologists and non-neurologists)

UCD including, TCD