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Patrick Murray

Full Professor of Clinical Pharmacology; Consultant Physician

School of Medicine
Health Sciences Centre
Belfield
Dublin 4

Tel: Ext: 6609
Email: head.medicine@ucd.ie

Biography

I am a Professor of Clinical Pharmacology at University College Dublin, and a consultant physician at the Mater Misericordiae University Hospital, Dublin, Ireland. I received my medical education at UCD. Following an internship at the Mater Misericordiae University Hospital in Dublin, I completed a residency in internal medicine at Hennepin County Medical Centre in Minneapolis, Minnesota, USA. I completed fellowship training programmes in nephrology, critical care medicine and clinical pharmacology at the University of Chicago Hospitals in Chicago, Illinois, USA. I am a board-certified in nephrology, critical care medicine and clinical pharmacology. I practiced as an intensivist, nephrologist and clinical pharmacologist at the University of Chicago Hospitals from 1996-2008, serving as the fellowship training Programme Director in nephrology, also directing the acute dialysis service.

 

I have a longstanding interest in research and education to improve the prevention, diagnosis and therapy of acute kidney injury and nephrotoxicity, and the pharmacotherapy of patients with kidney disease. I am Chair of the Mater Misericordiae University Hospital Drugs and Therapeutics Committee and Clinical Director of the UCD Clinical Research Centre. In 2011, I was appointed Associate Dean for International Affairs at UCD School of Medicine. In 2012, I was appointed Director of the Dublin Centre for Clinical Research Consortium Network and Dean and Head of the School of Medicine at UCD.

Publications

Books

Roy, A.K. and Murray, P. (2012) Management of heart failure with renal artery ischaemia. : Springer US. [DOI] [Details]
Murray, P. and Udani, S. and Koyner, J.L. (2011) Does renal replacement therapy improve outcome? Controversies in acute kidney injury. : S. Karger AG. [DOI] [Details]
Murray, P.T. (2011) Acute kidney injury biomarkers and endpoints for clinical trials. : S. Karger AG. [DOI] [Details]
Rao, M.V. and Koyner, J.L. and Murray, P.T. (2010) What is the value of Non-Dialytic therapy in acute kidney injury?. : Elsevier Inc. [DOI] [Details]

Book Chapters

McEvoy, C; Murray, PT (2015) 'Electrolyte disorders in critical care' In: Hall, JB; Schmidt, GA (eds). The Principles of Critical Care. New York: McGraw-Hill. [Details]
Hannon, C; Murray, PT (2015) 'Acute kidney injury' In: Hall, JB; Schmidt, GA; Kress, JP (eds). The Principles of Critical Care. New York: McGraw-Hill Education. [Details]
Murphy, N; Murray, PT (2015) 'Critical care pharmacology' In: Hall, JB; Schmidt, GA; Kress, JP (eds). The Principles of Critical Care. New York: McGraw-Hill Education. [Details]
Udani, SM; Koyner, JL; Murray, PT (2015) 'Renal replacement therapy in the intensive care unit' In: Hall, JB; Schmidt, GA; Kress, JP (eds). The Principles of Critical Care. New York: McGraw-Hill Education. [Details]
Gallagher HC, Murray PT (2014) 'Drug Dosing in Continuous Renal Replacement Therapy' In: Magee C, Tucker K, Singh A (eds). Current Concepts in Dialysis and Continuous Therapies. New York, USA: Springer. [Details]

Edited Books

Murray PT, Brady H, Hall JB (Ed.). (2005) Intensive Care in Nephrology. London, UK: Taylor & Francis. [Details]

Peer Reviewed Journals

Arulkumaran N, Deutschman CS;Pinsky MR;Zuckerbraun B;Schumacker PT;Gomez H;Gomez A;Murray P;Kellum JA; (2016) 'MITOCHONDRIAL FUNCTION IN SEPSIS'. Shock, 45 (3):271-281. [DOI] [Details]
Rimmel¿¿ T, Payen D;Cantaluppi V;Marshall J;Gomez H;Gomez A;Murray P;Kellum JA; (2016) 'IMMUNE CELL PHENOTYPE AND FUNCTION IN SEPSIS'. Shock, 45 (3):282-291. [DOI] [Details]
Agarwal A, Dong Z;Harris R;Murray P;Parikh SM;Rosner MH;Kellum JA;Ronco C; (2016) 'Cellular and Molecular Mechanisms of AKI'. Journal of the American Society of Nephrology : JASN, . [DOI] [Details]
Chawla LS, Fink M;Goldstein SL;Opal S;G¿¿mez A;Murray P;G¿¿mez H;Kellum JA; (2016) 'THE EPITHELIUM AS A TARGET IN SEPSIS'. Shock, 45 (3):249-258. [DOI] [Details]
Kellum JA, G¿¿mez H;G¿¿mez A;Murray P;Ronco C; (2016) 'ACUTE DIALYSIS QUALITY INITIATIVE (ADQI) XIV SEPSIS PHENOTYPES AND TARGETS FOR BLOOD PURIFICATION IN SEPSIS: THE BOGOT¿¿ CONSENSUS'. Shock, 45 (3):242-248. [DOI] [Details]
Ince C, Mayeux PR;Nguyen T;Gomez H;Kellum JA;Ospina-Tasc¿¿n GA;Hernandez G;Murray P;De Backer D; (2016) 'THE ENDOTHELIUM IN SEPSIS'. Shock, 45 (3):259-270. [DOI] [Details]
Reese PP, Hall IE;Weng FL;Schr¿¿ppel B;Doshi MD;Hasz RD;Thiessen-Philbrook H;Ficek J;Rao V;Murray P;Lin H;Parikh CR (2015) 'Associations between Deceased-Donor Urine Injury Biomarkers and Kidney Transplant Outcomes'. Journal of the American Society of Nephrology : JASN, . [DOI] [Details]
Ward F, Holian J;Murray PT (2015) 'Drug therapies to delay the progression of chronic kidney disease'. Clinical Medicine, 15 (6):550-557. [DOI] [Details]
Parikh CR, Hall IE;Bhangoo RS;Ficek J;Abt PL;Thiessen-Philbrook H;Lin H;Bimali M;Murray PT;Rao V;Schr¿¿ppel B;Doshi MD;Weng FL;Reese PP (2015) 'Associations of perfusate biomarkers and pump parameters with delayed graft function and deceased-donor kidney allograft function'. American Journal of Transplantation, . [DOI] [Details]
Murray, PT; Thakar, C (2015) 'Acute Kidney Injury and Critical Care Nephrology'. Nephrology Self-Assessment Programme (Neph SAP), 14 (2). [Details]
Godin M, Murray P;Mehta RL (2015) 'Clinical approach to the patient with AKI and sepsis'. Seminars in Nephrology, 35 (1):12-22. [DOI] [Details]
Mehta RL, Awdishu L;Davenport A;Murray PT;Macedo E;Cerda J;Chakaravarthi R;Holden AL;Goldstein SL (2015) 'Phenotype standardization for drug-induced kidney disease'. Kidney International, 88 (2):226-234. [DOI] [Details]
Raghunathan K, Murray PT;Beattie WS;Lobo DN;Myburgh J;Sladen R;Kellum JA;Mythen MG;Shaw AD; (2014) 'Choice of fluid in acute illness: what should be given? An international consensus'. British Journal of Anaesthesia, 113 (5):772-783. [DOI] [Details]
Devarajan P, Murray P (2014) 'Biomarkers in acute kidney injury: are we ready for prime time?'. Nephron - Clinical Practice, 127 (1-4):176-179. [DOI] [Details]
Roy AK, McCullagh BN;Segurado R;McGorrian C;Keane E;Keaney J;Fitzgibbon MN;Mahon NG;Murray PT;Gaine SP (2014) 'Detection of high-sensitivity troponin in outpatients with stable pulmonary hypertension identifies a subgroup at higher risk of adverse outcomes'. Journal of Cardiac Failure, 20 (1):31-37. [DOI] [Details]
Keaney JJ, Hannon CM;Murray PT (2013) 'Contrast-induced acute kidney injury: how much contrast is safe?'. Nephrology, Dialysis and Transplantation, 28 (6):1376-1383. [DOI] [Details]
Roy AK, Mc Gorrian C;Treacy C;Kavanaugh E;Brennan A;Mahon NG;Murray PT (2013) 'A Comparison of Traditional and Novel Definitions (RIFLE, AKIN, and KDIGO) of Acute Kidney Injury for the Prediction of Outcomes in Acute Decompensated Heart Failure'. CardioRenal Medicine, 3 (1):26-37. [DOI] [Details]
Haase M, Devarajan P, Haase-Fielitz A, Bellomo R, Cruz DN, Wagener G, Krawczeski CD, Koyner JL, Murray P, Zappitelli M, Goldstein SL, Makris K, Ronco C, Martensson J, Martling CR, Venge P, Siew E, Ware LB, Ikizler TA, Mertens PR:; (2011) 'The outcome of neutrophil gelatinase-associated lipocalin-positive subclinical acute kidney injury: a multicenter pooled analysis of prospective studies'. Journal of the American College of Cardiology, 57 (17):1752-1761. [Details]
Matzke GR, Aronoff GR, Atkinson AJ Jr, Bennett WM, Decker BS, Eckardt KU, Golper T, Grabe DW, Kasiske B, Keller F, Kielstein JT, Mehta R, Mueller BA, Pasko DA, Schaefer F, Sica DA, Inker LA, Umans JG, Murray P:; (2011) 'Drug dosing consideration in patients with acute and chronic kidney disease-a clinical update from Kidney Disease: Improving Global Outcomes (KDIGO)'. Kidney International, 2011 Sep 14. doi: 10.1038/ki.2011.322. [Epub ahead of print] . [Details]
Cullen R, MurrayPT, Fitzgibbon MC; (2011) 'Establishment of a reference interval for urinary neutrophil-associated lipocalin'. Annals of Clinical Biochemistry, . [Details]
Murray P, Udani S, Koyner J:; (2011) 'Does renal replacement therapy improve outcome? Controversies in acute kidney injury'. Contributions to nephrology, 174 :212-221. [Details]
Murray PT; (2011) 'Acute kidney injury biomarkers and endpoints for clinical trials'. Contributions to nephrology, 171 :208-212. [Details]
Koyner JL, Vaidya VS, Bennett MR, Ma Q, Worcester E, Akhter S, Raman S, Jeevanandam J, O¿ Connor MF, Devarajan P, Bonventre JV, Murray PT; (2010) 'Urinary Biomarkers in the Clinical Prognosis and Early Detection of Acute Kidney Injury'. Clinical Journal Of The American Society Of Nephrology, 5 (12):2154-2165. [Details]
Murray PT; (2010) 'The kidney in respiratory failure and mechanical ventilation'. Contributions to nephrology, 165 :159-165. [Details]
Cawood TJ, Bashir M, Brady J, Murray B, Murray PT, O'Shea D; (2010) 'Urinary Collagen IV and piGST: Potential Biomarkers for Detecting Localized Kidney Injury in Diabetes - A Pilot Study'. American Journal of Nephrology, 32 (3):219-225. [Details]

Other Journals

Rao MV, Murray P, Yancy CW; (2011) 'Management of heart failure with renal artery ischemia' Cardiology Clinics 29 (3) :433-455. [Details]
Murray PT; (2011) 'Diagnosis of kidney damage using novel acute kidney injury biomarkers: assessment of kidney function alone is insufficient' Critical Care 15 (4) :170-170. [Details]
McMahon BA, Koyner JL, Murray PT: ; (2010) 'Urinary glutathione S-transferases in the pathogenesis and diagnostic evaluation of acute kidney injury following cardiac surgery: a critical review' Current Opinion in Critical Care . [Details]
                         

Abstract

Ng, CH,Hannon, C,McMahon, B,Marsh, J,Murray, P (2011) EVALUATION OF NOVEL URINARY BIOMARKERS IN THE DETECTION OF ACUTE KIDNEY INJURY IN AN ADULT ICU POPULATION. Abstract [Details]
                         

Monographs:- Peer Reviewed

Murray PT, Liu KD; (2011) Acute Kidney Injury and Critical Care Nephrology. Monographs:- Peer Reviewed [Details]
                                   

Research

Research Interests

UCD Medicine Research Individual Investigator

Research Projects

Sponsor : University College Dublin Foundation Ltd.
Title : Translational Medicine and Pulmonary Hypertension
Start Date / End Date : 01-JUL-10 / 30-JUN-12
Sponsor : Health Research Board (HRB)
Title : Prospective Validation of Acute Kidney Injury Biomarkers in Critically Ill Patients
Start Date / End Date : 01-OCT-11 / 01-OCT-14
Sponsor : EC Framework (FP7)
Title : SAFE-T Consortium
Start Date / End Date : 01-JAN-11 / 14-JUN-15
Sponsor : University College Dublin Foundation Ltd.
Title : Ned Ryan Fellowship in Translational Oncology
Start Date / End Date : 01-APR-12 / 30-SEP-16
Sponsor : Abbott Laboratories
Title : Professional Services Agreement to Consult on cardiac biomarkers relating to the Abbott multi-centre AKINESIS study
Start Date / End Date : 16-MAR-10 / 15-MAR-13
Sponsor : Science Foundation Ireland (SFI)
Title : BCY1 - Breast Cancer in Young Women Conference 2012
Start Date / End Date : 01-SEP-12 / 28-FEB-13
Sponsor : Health Research Board (HRB)
Title : HRB Irish Clinical Research Infrastructure (ICRIN) Award - ICRIN Grant Ref.: ICR/2013/1
Start Date / End Date : 01-APR-13 / 30-JUN-14
Sponsor : Health Research Board (HRB)
Title : Epidemiology of sudden cardiac death in young adults in Ireland 2005-2014
Start Date / End Date : 02-JUN-15 / 27-JUL-15
Sponsor : University College Dublin (UCD)
Title : Charles Institute Research Award
Start Date / End Date : 01-AUG-12 / 31-JUL-16
Sponsor : The City of Dublin Skin and Cancer Hospital Charity
Title : Charles Institute Research Project
Start Date / End Date : 01-AUG-12 / 31-JUL-16
Sponsor : University College Dublin (UCD)
Title : Research Account for Prof Pat Murray's Research
Start Date / End Date : 01-JUN-13 / 30-SEP-17
Sponsor : University College Dublin (UCD)
Title : Start-up Fund
Start Date / End Date : 01-JAN-14 / 30-JUN-17
 

Current Postgraduate Students

Audrey Melvin, Doctor of Philosophy (PhD)   -   Secondary Supervisor
Lynn Redahan, Medicine (MD)   -   Thesis Supervisor