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Researchers at UCD

researcher

Paul McLoughlin

Conway Fellow

Conway Institute of Biomolecular & Biomedical Research

Tel: 353 1 716 6776
Email: paul.mcloughlin@ucd.ie

Biography

POSITIONS HELD

2004-present  Professor of Physiology, UCD
1998-2004 Associate Professor of Physiology, UCD
1996-1998 Statutory (Senior) Lecturer in Physiology, UCD
1993-1996 Lecturer in Physiology, UCD
1992-1993 Postgraduate Medical Training
1989-1993 Wellcome Research Fellow, UMDS, University of London
1987-1989 Lecturer in Medicine, Trinity College Dublin
1985-1987 Postgraduate Medical Training Dublin Hospitals
1984-1985 Medical Demonstrator, Physiology UCD
1983-1984 Postgraduate Medical Training St Vincent's University Hospital, Dublin



EDUCATION

1993 PhD, University of London
1987 Member Royal College of Physicians in Ireland
1985 BSc Physiology (Hons) University College Dublin
1983 MB BCh, BAO (Hons) University College Dublin

Professional

   

Patents

Patent PCT/EP2016/057846 : 'A lung perfusion solution, and use thereof for the ex-vivo preservation of a mammalian lung'
       

Employment

Employer: St. Thomas's Hospital / University of London
Position: Wellcome Trust Research Fellow
Employer: University College Dublin
Position: College Lecturer
Employer: University College Dublin
Position: Statutory Lecturer
Employer: Univerity College Dublin
Position: Honorary Lecturer
Employer: University College Dublin
Position: Associate Professor

Education

Year 1983 Institution: University of Auckland, NZ
Qualification: MB, BCh, BAO Subject:
Year 1985 Institution: University College Dublin
Qualification: BSc Subject:
Year 1992 Institution:
Qualification: PhD Subject:
Year 1986 Institution: Royal College of Physicians in Ireland
Qualification: MRCPI Subject: Medicine
     

Journals Edited

Experimental Physiology: Editor-in-Chief.
 

Publications

Books

Laffey, J.G. and O'Croinin, D. and McLoughlin, P. and Kavanagh, B.P. (2006) Permissive hypercapnia - Role in protective lung ventilatory strategies. : Springer Berlin Heidelberg. [DOI] [Details]

Book Chapters

Butler MW, McLoughlin P, Keane MP (2015) 'Chemokines, Adipokines, and Growth Factors in the Lung' In: Michael A. Grippi; co-editors,Jack A. Elias, Jay A. Fishman, Robert M. Kotloff, Allan I. Pack, Robert M. Senior (eds). Fishman's Pulmonary Diseases and Disorders, Fifth Edition. USA: McGraw-Hill Education. [Details]
Paul McLoughlin, Michael P. Keane; (2011) 'Physiological and Pathological Angiogenesis in the Adult Pulmonary Circulation' In: I. F. McMurtry, W. W. Wagner, T. Stevens, M. N. Gillespie (eds). Comprehensive Physiology. Hoboken, NJ, USA: Wiley Blackwell. , pp.1473-1508 Available Online [DOI] [Details]
 

Peer Reviewed Journals

McLoughlin P, Drummond G. (2017) 'Publishing replication studies to support excellence in physiological research'. Quarterly Journal of Experimental Physiology, 102 (9):1041-1043. Available Online [DOI] [Details]
Murphy N, Gaynor KU;Rowan SC;Walsh SM;Fabre A;Boylan J;Keane MP;McLoughlin P (2016) 'Altered Expression of Bone Morphogenetic Protein Accessory Proteins in Murine and Human Pulmonary Fibrosis'. The American journal of pathology, 186 (3):600-15. [DOI] [Details]
Rowan SC, Keane MP;Gaine S;McLoughlin P (2016) 'Hypoxic pulmonary hypertension in chronic lung diseases: novel vasoconstrictor pathways'. The Lancet. Respiratory medicine, 4 (3):225-36. [DOI] [Details]
McCullagh, BN; Costello, CM; Li, L; O'Connell, C; Codd, M; Lawrie, A; Morton, A; Kiely, DG; Condliffe, R; Elliot, C; McLoughlin, P; Gaine, S. (2015) 'Elevated plasma CXCL12α is associated with a poorer prognosis in pulmonary arterial hypertension'. PLoS ONE, 10 (4):e0123709. Available Online [DOI] [Details]
P McLoughlin (2015) 'Obesity and lung disease: a toxic mix'. Acta Physiologica Scandinavica, 213 (4):756-757. Available Online [DOI] Link to full text [Details]
Rowan, S. C. McLoughlin, P (2014) 'Hypoxic pulmonary hypertension: the paradigm is changing'. Experimental Physiology, 99 (6):837-838. Available Online [DOI] Link to full text [Details]
D Ryan S Frohlich P McLoughlin (2014) 'Pulmonary vascular dysfunction in ARDS'. Annals of intensive care, 4 (28). Available Online [DOI] [Details]
Fröhlich S, Boylan J, McLoughlin P (2013) 'Hypoxia-induced inflammation in the lung: a potential therapeutic target in acute lung injury?'. American Journal of Respiratory Cell and Molecular Biology, 48 (3):271-279. [Details]
McLoughlin P, Keane MP (2013) 'Physiological and pathological angiogenesis in the adult pulmonary circulation'. Comprehensive Physiology, 1 (3):1473-1508. [DOI] [Details]
McLoughlin P, Ward JP (2013) 'Hypoxic pulmonary hypertension; the load on the right ventricle'. Experimental Physiology, 98 (8):1244-1246. [Details]
Lili Li, Katherine Howell, Michelle Sands, Mark Banahan, Stephen Frohlich, Simon C Rowan, Roisín Neary, Donal Ryan, Paul McLoughlin (2013) 'The α and Δ isoforms of CREB1 are required to maintain normal pulmonary vascular resistance'. PLoS ONE, 8 (12):e80637. Available Online [DOI] [Details]
Adamali H, Armstrong ME, McLaughlin AM, Cooke G, McKone E, Costello CM, Gallagher CG, Leng L, Baugh JA, Fingerle-Rowson G, Bucala RJ, McLoughlin P, Donnelly SC. (2012) 'Macrophage Migration Inhibitory Factor Enzymatic Activity, Lung Inflammation and Cystic Fibrosis'. American Journal of Respiratory and Critical Care Medicine, . Available Online [Details]
Cahill E, Rowan SC, Sands M, Banahan M, Ryan D, Howell K, McLoughlin P; (2012) 'The pathophysiological basis of chronic hypoxic pulmonary hypertension in the mouse: vasoconstrictor and structural mechanisms contribute equally'. Experimental Physiology, 97 (6):796-806. [DOI] [Details]
Cahill E, Costello CM, Rowan SC, Harkin S, Howell K, Leonard MO, Southwood M, Cummins EP, Fitzpatrick SF, Taylor CT, Morrell NW, Martin F, McLoughlin P; (2012) 'Gremlin plays a key role in the pathogenesis of pulmonary hypertension'. Circulation, 125 (7):920-930. Available Online [DOI] Link to full text [Details]
Oliver KM, Lenihan CR, Bruning U, Cheong A, Laffey JG, McLoughlin P, Taylor CT, Cummins EP; (2012) 'Hypercapnia induces cleavage and nuclear localization of REL B giving insight into co2 sensing and signalling'. Journal of Biological Chemistry, . [DOI] Link to full text [Details]
Sands, M,Howell, K,Costello, CM,McLoughlin, P; (2011) 'Placenta growth factor and vascular endothelial growth factor B expression in the hypoxic lung'. Respiratory research, 12 . [DOI] [Details]
Costello CM, McCullagh B, Howell K, Sands M, Belperio JA, Keane MP, Gaine S, McLoughlin P.; (2011) 'A role for the CXCL12 receptor, CXCR7, in the pathogenesis of human pulmonary vascular disease'. European Respiratory Journal, . [Details]
Cummins, EP,Oliver, KM,Lenihan, CR,Fitzpatrick, SF,Bruning, U,Scholz, CC,Slattery, C,Leonard, MO,McLoughlin, P,Taylor, CT; (2010) 'NF-kappa B Links CO2 Sensing to Innate Immunity and Inflammation in Mammalian Cells'. Journal of Immunology, 185 :4439-4445. [DOI] [Details]
McLoughlin P, Costello CM, Cahill E, Martin F, Gaine S, ; (2010) 'Role of Gremlin in the Lung: Development and Disease'. American Journal of Respiratory Cell and Molecular Biology, 42 (5):517-523. [DOI] [Details]
Hsia CC, Hyde DM, Ochs M, Weibel ER on behalf of ATS/ERS Joint Task Force on Quantitative Assessment of Lung Structure.; (2010) 'An official research policy statement of the American Thoracic Society/European Respiratory Society: standards for quantitative assessment of lung structure'. American Journal of Respiratory and Critical Care Medicine, 181 (4):394-418. [DOI] [Details]
Nichol AD, O'Cronin D F, Naughton F, Hopkins N, Boylan J, McLoughlin P.; (2010) 'Hypercapnic acidosis reduces oxidative reactions in endotoxin-induced lung injury'. Anesthesiology, 113 (1):116-125. [DOI] [Details]
Howell, K,Costello, CM,Sands, M,Dooley, I,McLoughlin, P; (2009) 'L-Arginine promotes angiogenesis in the chronically hypoxic lung: a novel mechanism ameliorating pulmonary hypertension'. American journal of physiology. Lung cellular and molecular physiology, 296 (NA):1042-1050. [DOI] [Details]
Nichol, AD,O'Cronin, DF,Howell, K,Naughton, F,O'Brien, S,Boylan, J,O'Connor, C,O'Toole, D,Laffey, JG,McLoughlin, P; (2009) 'Infection-induced lung injury is worsened after renal buffering of hypercapnic acidosis'. Critical Care Medicine, 37 :2953-2961. [DOI] [Details]
O'Croinin, D. F., Nichol, A. D., Hopkins, N., Boylan, J., O'Brien, S., O'Connor, C., Laffey, J. G., McLoughlin, P., ; (2008) 'Sustained hypercapnic acidosis during pulmonary infection increases bacterial load and worsens lung injury'. Critical Care Medicine, 36 (7):2128-2135. [Details]
C Costello, K Howell, E Cahill, J McBryan, M Konigshoff, O Eickelberg, S Gaine, F Martin, P McLoughlin; (2008) 'Lung Selective Gene Responses to Alveolar Hypoxia: Potential Role for the Bone Morphogenetic Antagonist Gremlin in Pulmonary Hypertension'. American Journal of Physiology - Lung Cellular and Molecular Physiology, 295 (2):L272-L284. Available Online [DOI] [Details]
McLoughlin P, Leonard MO, Howell K, Madden SF, Costello CM, Higgins DG, Taylor CT, ; (2008) 'Hypoxia selectively activates the CREB family of transcription factors in the in vivo lung'. American Journal of Respiratory and Critical Care Medicine, 178 (9):977-983. Available Online [DOI] [Details]
Foley, S. C.,Hopkins, N. O.,Fitzgerald, M. X.,Donnelly, S. C.,McLoughlin, P.; (2007) 'Airway nitric oxide output is reduced in bronchiectasis'. Respir Med, 101 (7):1549-1555. [Details]
McLoughlin P, McMurtry I; (2007) 'Counterpoint: Chronic Hypoxia-induced Pulmonary Hypertension does not Lead to Loss of Pulmonary Vasculature'. Journal of Applied Physiology, 103 (4):1451-1453. [Details]
McLoughlin, P.,McMurtry, I.; (2007) 'Last Word on Point:Counterpoint "Chronic hypoxia-induced pulmonary hypertension does/does not lead to loss of pulmonary vasculature"'. J Appl Physiol, 103 (4):1456. [Details]
Hopkins, N,Gunning, Y,O'Croinin, DF,Laffey, J,McLoughlin, P; (2006) 'Anti-inflammatory effect of augmented nitric oxide production in chronic lung infection'. Journal of Pathology, 209 :198-205. [DOI] [Details]
Tsuchida, S, Engelberts, D, Peltekova, V, Hopkins, N, Frndova, H, Babyn, P, McKerlie, C, Post, M, McLoughlin, P, Kavanagh, BP, ; (2006) 'Atelectasis causes alveolar injury in nonatelectatic lung regions'. American Journal of Respiratory and Critical Care Medicine, 174 (3):279-289. [Details]
McLoughlin P, Hyvelin JM, Howell K.; (2005) 'Pulmonary hypertension'. New England Journal of Medicine, 352 (4):418-419. [Details]
O'Croinin, DF; Hopkins, NO; Moore, MM; Boylan, JF; McLoughlin, P; Laffey, JG; ; (2005) 'Hypercapnic acidosis does not modulate the severity of bacterial pneumonia-induced lung injury'. Critical Care Medicine, 33 (11):2606-2612. [Details]
Thin, AG; Kelly, GE; Daly, L; McLoughlin, P; ; (2005) 'Repeated measurement of the gas exchange threshold: relative size of measurement and biological variabilities'. Computers in Biology and Medicine, 35 (8):703-716. [Details]
Cleary, C; Buckley, CH; Henry, E; McLoughlin, P; O'Brien, C; Hadoke, PWF; ; (2005) 'Enhanced endothelium derived hyperpolarising factor activity in resistance arteries from normal pressure glaucoma patients: implications for vascular function in the eye'. British Journal of Ophthalmology, 89 (2):223-228. [Details]
Hyvelin JM, Howell K, Nichol A, Costello CM, Preston RJ, McLoughlin P. (2005) 'Inhibition of Rho-kinase attenuates hypoxia-induced angiogenesis in the pulmonary circulation'. Circulation Research, 97 (2):185-191. Available Online [DOI] [Details]
Thin, AG,Dodd, JD,Gallagher, CG,Fitzgerald, MX,McLoughlin, P; (2004) 'Effect of respiratory rate on airway deadspace ventilation during exercise in cystic fibrosis'. Respiratory Medicine, 98 :1063-1070. [DOI] [Details]
Shortt, AJ; Howell, K; O'Brien, C; McLoughlin, P; ; (2004) 'Chronic systemic hypoxia causes intra-retinal angiogenesis'. Journal of Anatomy, 205 (5):349-356. [Details]
Varadarajan, R; Golden-Mason, L; Young, L; McLoughlin, P; Nolan, N; McEntee, G; Traynor, O; Geoghegan, T; Hegarty, JE; O'Farrell, C; ; (2004) 'Nitric oxide in early ischaemia reperfusion injury during human orthotopic liver transplantation'. Transplantation, 78 (2):250-256. [Details]
Laffey, JG; Honan, D; Hopkins, N; Hyvelin, JM; Boylan, JF; McLoughlin, P; ; (2004) 'Hypercapnic acidosis attenuates endotoxin-induced acute lung injury'. American Journal of Respiratory and Critical Care Medicine, 169 (1):46-56. [Details]
Laffey, JG; O'Croinin, D; McLoughlin, P; Kavanagh, BP; ; (2004) 'Permissive hypercapnia - role in protective lung ventilatory strategies'. Journal of Intensive Care Medicine, 30 (3):347-356. [Details]
McLoughlin P, Howell K, Ooi H, Preston R, ; (2004) 'Structural basis of hypoxic pulmonary hypertension: the modifying effect of chronic hypercapnia'. Experimental Physiology, 89 (1):66-72. [Details]
Hopkins, N; Cadogan, E; Giles, S; Bannigan, J; McLoughlin, P; ; (2003) 'Type 2 nitric oxide synthase and protein nitration in chronic lung infection'. Pathology, 199 (1):122-129. [Details]
Loughrey, JPR; Laffey, JG; Moore, BJ; Lynch, F; Boylan, JF; McLoughlin, P; ; (2003) 'Interleukin-1 beta rapidly inhibits aortic endothelium-dependent relaxation by a DNA transcription-dependent mechanism'. Critical Care Medicine, 31 (3):910-915. [Details]
Howell, K; Preston, RJ; McLoughlin, P; ; (2003) 'Chronic hypoxia causes angiogenesis in addition to remodelling in the adult rat pulmonary circulation'. Journal of Physiology, 547 (1):133-145. [Details]
Kilbride, E; McLoughlin, P; Gallagher, CG; Harty, HR; ; (2003) 'Do gender differences exist in the ventilatory response to progressive exercise in males and females of average fitness?'. European Journal of Applied Physiology, 89 (6):595-602. [Details]
Quinn, S, O'Brien, C, McLoughlin, P, ; (2003) 'Role of cyclooxygenase and haemoxygenase products in nitric oxide-independent vasodilatation in the porcine ciliary artery'. Eye, 17 (5):628-636. [DOI] [Details]
Thin, AG,Linnane, SJ,McKone, EF,Freaney, R,FitzGerald, MX,Gallagher, CG,McLoughlin, P; (2002) 'Use of the gas exchange threshold to noninvasively determine the lactate threshold in patients with cystic fibrosis'. Chest, 121 :1761-1770. [Details]
Kennelly, MM; Geary, M; McCaffrey, N; McLoughlin, P; Staines, A; McKenna, P; ; (2002) 'Exercise-related changes in umbilical and uterine artery waveforms as assessed by Doppler ultrasound scans'. American Journal of Obstetrics and Gynecology, 187 (3):661-666. [Details]
Hopkins, N; McLoughlin, P; ; (2002) 'The structural basis of pulmonary hypertension in chronic lung disease: remodelling, rarefaction or angiogenesis?'. Journal of Anatomy, 201 (4):335-348. [Details]
Howell, K; Hopkins, N; McLoughlin, P; ; (2002) 'Combined confocal microscopy and stereology: a highly efficient and unbiased approach to quantitative structural measurement in tissues'. Experimental Physiology, 87 (6):747-756. [Details]
Kelly G.E., Thin A., Daly L., McLoughlin P.; (2002) 'Erratum. Estimation of the gas exchange threshold in humans: a time series approach'. European Journal of Applied Physiology and Occupational Physiology, 87 :588-588. [Details]
Hopkins, N; Cadogan, E; Giles, S; McLoughlin, P; ; (2001) 'Chronic airway infection leads to angiogenesis in the pulmonary circulation'. Journal of Applied Physiology, 91 (2):919-928. [Details]
Linnane, SJ; Thin, AG; Keatings, VM; Moynihan, JB; McLoughlin, P; FitzGerald, MX; ; (2001) 'Glucocorticoid treatment reduces exhaled nitric oxide in cystic fibrosis patients'. European Respiratory Journal, 17 (6):1267-1270. [Details]
Kelly G.E. ,Thin A., Daly L., McLoughlin P.; (2001) 'Estimation of the gas exchange threshold in humans: a time series approach'. European Journal of Applied Physiology and Occupatioal, 85 :586-592. [Details]
O'Connor, S,McLoughlin, P,Gallagher, CG,Harty, HR; (2000) 'Ventilatory response to incremental and constant-workload exercise in the presence of a thoracic restriction'. Journal of Applied Physiology, 89 :2179-2186. [Details]
Lynch, F; Sweeney, M; O'Regan, RG; McLoughlin, P; ; (2000) 'Hypercapnia-induced contraction in isolated pulmonary arteries is endothelium-dependent'. Respiration Physiology, 121 (1):65-74. [Details]
Ooi, H, Cadogan, E, Sweeney, M, Howell, K, O'Regan, RG, McLoughlin, P, ; (2000) 'Chronic hypercapnia inhibits hypoxic pulmonary vascular remodeling'. American Journal of Physiology - Heart and Circulatory Physiology, 278 (2):331-338. [Details]
Sweeney, M,O'Regan, RG,McLoughlin, P; (1999) 'Effects of changes in pH and P-CO2 on wall tension in isolated rat intrapulmonary arteries'. Experimental Physiology, 84 :529-539. [Details]
Cadogan, E; Hopkins, N; Giles, S; Bannigan, JG; Moynihan, J; McLoughlin, P; ; (1999) 'Enhanced expression of inducible nitric oxide synthase without vasodilator effect in chronically infected lungs'. American Journal of Physiology-Lung Cellular and Molecular Physiology, 277 (3):616-627. [Details]
Thin, A.G., Hamzah, Z., FitzGerald, M.X., McLoughlin, P., and Freaney, R.; (1999) 'Lactate determination in exercise testing using an electrochemical analyser: with or without blood lysis'. European Journal of Applied Physiology and Occupatioal, 79 (2):115-159. [Details]
Linnane, SJ; Keatings, VM; Costello, CM; Moynihan, JB; O'Connor, CM; Fitzgerald, MX; McLoughlin, P; ; (1998) 'Total sputum nitrate plus nitrite is raised during acute pulmonary infection in cystic fibrosis'. American Journal of Respiratory and Critical Care Medicine, 158 (1):207-212. [Details]
Sweeney, M; Beddy, D; Honner, V; Sinnott, B; O'Regan, RG; McLoughlin, P; ; (1998) 'Effects of changes in pH and CO2 on pulmonary arterial wall tension are not endothelium dependent'. Journal of Applied Physiology, 85 (6):2040-2046. [Details]
O'Donnell DM, Moynihan J, Finlay GA, Keatings VM, O' Connor CM, McLoughlin P, FitzGerald MX. ; (1997) 'Exhaled nitric oxide and BAL nitrite / nitrate in active pulmonary sarcoidosis'. American Journal of Respiratory and Critical Care Medic, 156 :1892-1896. [Details]
Boutcher, PA; Gaffney, PJ; Raut, S; ORegan, RG; McLoughlin, P; ; (1996) 'Effects of early plasmin digests of fibrinogen on isometric tension development in isolated rings of rat pulmonary artery'. Thrombosis Research, 81 (2):231-239. [Details]
MCLOUGHLIN, P, MCCAFFREY, N, MOYNIHAN, JB, ; (1991) 'GENTLE EXERCISE WITH A PREVIOUSLY INACTIVE MUSCLE GROUP HASTENS THE DECLINE OF BLOOD LACTATE CONCENTRATION AFTER STRENUOUS EXERCISE'. European Journal of Applied Physiology and Occupational Physiology, 62 (4):274-278. [Details]
 

Conference Publications

Dr. Brian McCullagh, Christine Costello, christine.costello@ucd.ie, Sean Gaine, sgaine@mater.ie, Paul McLoughlin; (2010) CXCL12 as a potential disease marker for pulmonary hypertension European Respiratory Society Annual Congress [Details]
BN McCullagh, CM Costello, K Howell, M Leonard, P McLoughlin, S Gaine; (2010) Lung selective hypoxia response pathways predict changes in cognate ligands in the plasma of pulmonary arterial hypertensive patients American Thoracic Society International Conference 2010 [Details]
Cahill E, Costello CM, Howell K, Harkin S, Leonard MO, Southwood M, Morrell NW, McLoughlin P; (2010) Novel Autocrine Function of the BMP Antagonist Gremlin: a Key Role in Hypoxic Pulmonary Hypertension American Thoracic Society International Conference 2010 [Details]
Cahill E, Costello CM, Howell K, Southwood M, Leonard, M.O., Morrell NW, McLoughlin P; (2010) Lung-Selective Hypoxia-Induced Secretion of the BMP Antagonist Gremlin in Pulmonary Hypertension Keystone Symposium [Details]
Coyle-Rowan S, Cahill E, Harkin S, Costello CM, Howell K, Martin F, McLoughlin P; (2010) Hypoxic upregulation of the BMP antagonist gremlin1 contributes to the development of pulmonary hypertension Physiological Society Main Meeting (2010), Birmingham; Proc Physiol Soc 20, PC06 Available Online [Details]
Costello, CM, Howell K, Doherty S, Martin, F, Belperio J, Keane MP, Gaine, S, McLoughlin, P (2010) CXCL12 signalling in hypoxic pulmonary hypertension American Thoracic Society annual meeting, New Orleans 2010 , pp.A5225 [Details]
Cahill E, Costello CM, Howell K, Leonard MO, Southwood M, Morrell NW, McLoughlin P; (2009) Hypoxic Upregulation of the BMP Antagonist Gremlin Blocks BMP Signalling in Pulmonary Endothelial Cells Physiological Society Annual Meeting [Details]
Cahill E, Costello CM, Howell K, Leonard MO, Southwood M, Morrell NW, McLoughlin P; (2009) Hypoxic Upregulation of the BMP Antagonist Gremlin Blocks BMP Signalling in Pulmonary Endothelial Cells European Respiratory Society Lung Biology Meeting [Details]
Michelle Sands, Katherine Howell, Christine Costello, Paul McLoughlin; (2009) VEGF Family Members can Inhibit Angiogenesis in the Hypoxic Lung Physiological Society Annual General Meeting [Details]
Costello CM, Howell K, Doherty S, Martin F, Belperio J, Keane M, Gaine, S, McLoughlin, P; (2009) Potential selective role for CXCR7/CXCL12 signalling in the lung in response to hypoxic stress Physiological Society Annual General Meeting [Details]
Costello, CM, Howell K, Brennan D, Doherty S, Martin, F, Gaine, S, McLoughlin, P; (2009) Potential selective role for CXCR7/CXCL12 signalling in the lung in response to hypoxic stress European Respiratory Society Lung Biology Meeting [Details]
Nichol A, O'Croinin D, Naughton F, Boylan J, McLoughlin P; (2008) Buffered Hypercapnia worsens E coli induced Lung Injury in vivo American Thoracic Society International Conference [Details]
Adamali HI, Baugh J, Fingerle-Rowson G, McLoughlin P, Donnelly SC; (2008) Enzymatic actvity of macrophage inhibitory factor (MIF) regulates growth of pseudomonas aeruginosa (Pa): implications for therapeutic interventions in cystic fibrosis American Thoracic Society International Conference [Details]
MO Leonard, K Howell, CT Taylor, P McLoughlin. ; (2008) Hypoxic activation of CREB as a mediator of transcriptional alteration within the mouse lung Keystone Conference [Details]
K Howell, C Costello, M Sands, P McLoughlin ; (2008) Hypoxia-induced angiogenesis in the lung is nitric oxide dependent American Thoracic Society International Conference [Details]
CM Costello, E Cahill, K Howell, P McLoughlin; (2008) Bone morphogenetic protein signalling pathway in chronic hypoxic lung disease Keystone Conference [Details]
M. Sands, K. Howell, P. McLoughlin; (2008) Pulmonary Hypertension; Stereological Quantification of Intra-Acinar Vessel Length by Lumen Diameter Distribution American Thoracic Society International Conference [Details]
MJ O'Mahony, V Lyons, H Misran, CM Greene, N Hopkins, P McLoughlin, NG McElvaney, MD; (2007) Large airway morphological changes in COPD American Thoracic Society International Conference [Details]
M. Sands, K. Howell, C. Costello, P. McLoughlin; (2007) Angiogenic growth factor expression in the chronically hypoxic lung European Respiratory Society Lung Science Conference [Details]
MJ O'Mahony, V Lyons, H Misran, CM Greene, N Hopkins, P. McLoughlin, NG McElvaney,; (2007) Never smoking patients with Alpha-1 antitrypsin deficiency have morphometrically normal large airway epithelium American Thoracic Society International Conference [Details]
Nichol A, Naughton F, OCroinin D, McLoughlin P; (2007) Buffered Hypercapnia worsens lung injury in endotoxin induced pneumonia American Thoracic Society International Conference [Details]
CM Costello, K Howell, F Martin, P McLoughlin; (2007) Expression Profiling Of Cellular Responses To Hypoxia By The Pulmonary Endothelium American Thoracic Society International Conference [Details]
MO. Leonard, K Howell, CT Taylor, Pl McLoughlin.; (2007) Hypoxia induced alterations in the transcriptional profile of the mouse lung European Respiratory Society Lung Science Conference [Details]
Katherine Howell, Christine Costello and Paul McLoughlin ; (2007) The Effects of Nitric Oxide on Pulmonary Hypertension and Vessel Size Distribution Physiological Society Annual Meeting, Glasgow [Details]
Alistair Nichol, Finola Naughton, Donall O Croinin, John Boylan, Paul McLoughlin; (2007) Buffered hypercapnia in acute lung injury Australia New Zealand Intensive Care Society Annual Scientific Meeting [Details]
Alistair Nichol, Finola Naughton, Donall O Croinin, John Boylan, Paul McLoughlin; (2007) Hypercapnic acidosis attenuates the neutrophil inflammatory response Australia New Zealand Intensive Care Society Annual Scientific Meeting [Details]
Nichol, A., Howell, K., Costello, C. McLoughlin, P.; (2006) Reversal of vasoconstriction in chronically hypoxic hypertensive lungs does not alter the alveolar arterial oxygen gap Keystone Conferrnce [Details]
Gunning, Y., Hopkins, N. McLoughlin, P.; (2006) Thalidomide treatment in chronic lung infection American Thoracic Society [Details]
Nichol, A., Naughton, F., O`Cronin, D., Boylan, J., Laffey, J. Mc Loughlin, P.; (2006) Buffered hypercapnia worsens lung injury in endotoxin induced lung injury College of Anaesthetists [Details]
Keane, PA, O'Brien, C, McLoughlin, P, ; (2005) INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE The role of the nitric oxide precursor, L-arginine in angiogenesis involving the globally hypoxic adult retina [Details]
Nichol, A., Howell, K. Mc Loughlin, P.; (2005) Reversal of vasoconstriction in chronically hypoxic hypertensive lungs does not alter the alveolar arterial oxygen gap Physiological Society Smooth Muscle Symposium [Details]
Gunning, Y., Hopkins, N. McLoughlin, P.; (2005) Thalidomide treatment in chronic lung infection Irish Thoracic Society [Details]
Nichol, A., O`Cronin, D., Naughton, F. McLoughlin, P.; (2005) Hypercapnia does not attenuate oxidation in endotoxin induced Acute Lung Injury Irish Thoracic Socitey [Details]
Quinn, S, O'Brien, C, McLoughlin, P, ; (2003) EYE Role of cyclooxygenase and haemoxygenase products in nitric oxide-independent vasodilatation in the porcine ciliary artery , pp.628-636 [DOI] [Details]
Varadarajan, R, Young, L, Quinlan, M, McLoughlin, P, Geoghegan, J, Traynor, O, McEntee, G, Hegarty, JE, O'Farrelly, C, ; (2002) BRITISH JOURNAL OF SURGERY Nitric oxide expression following reperfusion in human orthotopic liver transplantation , pp.669-669 [Details]
Howell, K, Ooi, H, Giles, J, McLoughlin, P, ; (2000) JOURNAL OF PHYSIOLOGY-LONDON Chronic hypoxia increases alveolar capillary endothelial surface area in adult rats , pp.294-295 [Details]
Kilbride, E, McLoughlin, P, Gallagher, C, Harty, H, ; (2000) JOURNAL OF PHYSIOLOGY-LONDON The incidence of exercise-induced hypoxaemia in a normal healthy female population , pp.49-49 [Details]
Adamali, HI, Sweeney, M, O'Regan, RG, McLoughlin, P, ; (2000) JOURNAL OF PHYSIOLOGY-LONDON Role of plasmalemmal Ca2+-ATPase in acidosis-induced relaxation in isolated rat pulmonary and aortic rings , pp.291-292 [Details]
Sweeney, M, O'Regan, RG, McLoughlin, P, ; (1998) JOURNAL OF PHYSIOLOGY-LONDON Effects of hypercapnic acidosis on vascular smooth muscle tone in isolated rat intrapulmonary arteries , pp.174-174 [Details]
Ooi, H, Cadogan, E, O'Regan, R, McLoughlin, P, ; (1998) JOURNAL OF PHYSIOLOGY-LONDON Chronic hypercapnia inhibits hypoxic pulmonary vasoconstriction by a NO-independent mechanism in chronically hypoxic rats , pp.109-110 [Details]
Hopkins, N, Cadogan, E, Giles, S, Bannigan, J, McLoughlin, P, ; (1998) JOURNAL OF PHYSIOLOGY-LONDON Immunolocalization of inducible nitric oxide synthase (iNOS) and its effects on pulmonary vasoreactivity following chronic Pseudomonas aeruginosa infection in the rat , pp.110-110 [Details]
Beddy, D, McLoughlin, P, ; (1996) JOURNAL OF PHYSIOLOGY-LONDON Effects of hypercapnia on phenylephrine-induced tension and endothelium-dependent relaxation in isolated rings of rat pulmonary artery , pp.54-54 [Details]
BOUTCHER, PA, GAFFNEY, PJ, RAUT, S, MCLOUGHLIN, P, ; (1995) JOURNAL OF PHYSIOLOGY-LONDON EFFECTS OF EARLY AND LATE PLASMIN DIGESTS OF FIBRINOGEN ON ISOMETRIC TENSION DEVELOPMENT IN ISOLATED RINGS OF RAT PULMONARY-ARTERY , pp.164-165 [Details]
       

Editorial

Drummond, GB,Paterson, DJ,McLoughlin, P,McGrath, JC; (2011) Statistics: All Together Now, One Step at a Time. Editorial [DOI] [Details]
McLoughlin, P,McMurtry, I; (2007) Counterpoint: Chronic hypoxia-induced pulmonary hypertension does not lead to loss of pulmonary vasculature. Editorial [Details]
                                                                                                   

Comment

McLoughlin P (2015) Obesity and lung disease: a toxic mix. Comment [DOI] [Details]
                       

Research

Research Interests

Our research group is focused on the exploration and understanding of key mechanisms in the development and progression of lung diseases. These diseases including chronic obstructive pulmonary disease (COPD), emphysema, cystic fibrosis, adult respiratory distress syndrome and occupational lung diseases and are amongst the most common (and increasing) causes of death and disability worldwide. The number of effective therapies currently available is small due to our limited understanding of the underlying disease mechanisms. 

Lung diseases all cause reduced oxygen in the lung which then activates mechanisms that are pro-inflammatory, pro-thrombotic and promote maladaptive vascular remodelling.  Our current research is focused on understanding the specific mechanisms in the lung through which hypoxia promotes these disease responses.  An understanding of these mechanisms allows us to identify potential therapeutic strategies that can be used to target the disease process within the lung without causing unwanted adverse effects in other organs.   

Research Projects

Sponsor : University College Dublin (UCD)
Title : Pilot study on the use of exhaled breath condensates to measure key signalling proteins in patients with pulmonary hypertension
Start Date / End Date : 01-AUG-06 / 31-JAN-07
Sponsor : College of Anaesthetists of Ireland (CAI)
Title : Abbot Scholarship
Start Date / End Date : 01-JAN-06 / 31-DEC-07
Sponsor : Mater Misericordiae University Hospital
Title : Pulmonary Hypertension: Basic mechanisms in human lung disease
Start Date / End Date : 30-OCT-05 / 29-OCT-07
Sponsor : Health Research Board (HRB)
Title : Hypoxic Lung Disease
Start Date / End Date : 01-OCT-05 / 01-OCT-11
Sponsor : Health Research Board (HRB)
Title : Role of Gremlin in the pathogenesis of chronic hypoxic lung disease
Start Date / End Date : 01-SEP-06 / 30-AUG-09
Sponsor : St. Vincent's University Hospital
Title : Hypoxia-hypercapnia interactions in inflammation
Start Date / End Date : 01-JUN-06 / 30-MAY-08
Sponsor : UCD School of Medicine and Medical Science
Title : Sleep Study
Start Date / End Date : 01-JAN-06 / 01-JAN-08
Sponsor : Enterprise Ireland (EI)
Title : Responses of pulmonary vascular smooth muscle.
Start Date / End Date : 01-NOV-94 / 31-OCT-96
Sponsor : Private Funds
Title : No Project title to migrate.
Start Date / End Date : 01-JAN-95 / 08-JAN-95
Sponsor : Health Research Board (HRB)
Title : No Project title to migrate.
Start Date / End Date : 01-JUL-95 / 30-JUN-96
Sponsor : Health Research Board (HRB)
Title : CF Research Unit
Start Date / End Date : 01-SEP-95 / 31-DEC-99
Sponsor : Health Research Board (HRB)
Title : No Project title to migrate.
Start Date / End Date : 01-JUL-96 / 30-JUN-97
Sponsor : Cystic Fibrosis Association of Ireland (CFAI)
Title : No Project title to migrate.
Start Date / End Date : 01-OCT-97 / 30-SEP-99
Sponsor : Health Research Board (HRB)
Title : No Project title to migrate.
Start Date / End Date : 01-AUG-98 / 01-AUG-01
Sponsor : Irish Lung Foundation
Title : Measuring Intracellular pH changes in freshly isolated pulmonary and systematic vascular smooth muscle cells
Start Date / End Date : 01-DEC-98 / 31-JAN-99
Sponsor : Higher Education Authority (HEA)
Title : Conway Core Technology Confocal Microscopy
Start Date / End Date : 01-MAY-00 / 30-APR-01
Sponsor : Health Research Board (HRB)
Title : The role of Rho A in the control of vascular resistance in normal and chronically hypoxic lungs
Start Date / End Date : 01-OCT-00 / 30-SEP-03
Sponsor : Health Research Board (HRB)
Title : Chemiluminescent Nitric oxide analyser, Sievers NOA-280
Start Date / End Date : 01-SEP-00 / 31-AUG-01
Sponsor : Irish Lung Foundation
Title : Protective effects of hypercapnic acidosis
Start Date / End Date : 01-JAN-01 / 31-DEC-02
Sponsor : Health Research Board (HRB)
Title : The protective effects of hypercapnic acidosis in sepsis-induced lung injury
Start Date / End Date : 01-JUL-01 / 30-JUN-03
Sponsor : Health Research Board (HRB)
Title : Somatic Gene Transfer in chronic lung infection
Start Date / End Date : 01-FEB-02 / 31-JAN-05
Sponsor : Health Research Board (HRB)
Title : Investigation of the effects of hypercapnic acidosis on acute lung injury induced by bacterial infection.
Start Date / End Date : 01-JUL-02 / 30-JUN-04
Sponsor : Health Research Board (HRB)
Title : The role of Rho/Rho-kinase in the pulmonary vascular remodelling in chronically hypoxic lungs.
Start Date / End Date : 01-OCT-02 / 30-SEP-05
Sponsor : Health Research Board (HRB)
Title : Angiogenesis in the pulmonary circulation: Pathogenetic role in chronic lung infection
Start Date / End Date : 01-OCT-02 / 30-SEP-05
Sponsor : Higher Education Authority (HEA)
Title : Gene Therapy Approaches to Human Disease in Pre-Clinical Models
Start Date / End Date : 01-NOV-02 / 31-OCT-05
Sponsor : Health Research Board (HRB)
Title : Stereological Morphometry: Quantitative Assessment of Disease-induced angiogenesis and tissue remodelling
Start Date / End Date : 01-DEC-03 / 31-MAY-04
Sponsor : Irish Research Council for Science Engineering and Technology (IRCSET)
Title : Protective Effect of Hypercapnic Acidosis in Acute Lung Injury: A Role for Peroxynitrite. Candidate: Alistair Nichol
Start Date / End Date : 01-OCT-04 / 30-SEP-07
Sponsor : St. Vincent's University Hospital
Title : Lung injury and remodelling
Start Date / End Date : 01-JUN-04 / 01-JUL-07
Sponsor : Intensive Care Society of Ireland
Title : Hypercapnic Acidosis and Peroynitrite
Start Date / End Date : 01-DEC-04 / 30-NOV-06
Sponsor : Irish Lung Foundation
Title : Macrophage Migration Inhibitory Factor (MIF) and Pseudomonas Infection
Start Date / End Date : 01-JUN-06 / 01-JUN-07
Sponsor : University College Dublin (UCD)
Title : In vivo models of hypoxic lung disease
Start Date / End Date : 26-MAY-08 / 01-DEC-09
Sponsor : Actelion Pharmaceuticals UK Ltd
Title : Actelion Pharmaceuticals Newman Fellowship in Translational Medicine and Pulmonary Hypertension
Start Date / End Date : 01-JUL-08 / 30-JUN-10
Sponsor : University College Dublin (UCD)
Title : Novel Autocrine Function of the BMP Antagonist Gremlin: a Key Role in Hypoxic Pulmonary Hypertension
Start Date / End Date : 17-MAY-10 / 16-NOV-11
Sponsor : The Wellcome Trust (WT)
Title : Development of a new method for stereological quantification of vascular structures in the mouse lung at standard vascular transmural pressures.
Start Date / End Date : 02-JUN-14 / 28-JUL-14
Sponsor : Enterprise Ireland (EI)
Title : UCD Technologies: Modified viscosity solution for ex vivo lung preservation
Start Date / End Date : 20-JAN-15 / 20-APR-15
Sponsor : Science Foundation Ireland (SFI)
Title : The role of the bone morphogenetic antagonist gremlin in the pathogenesis of chronic hypoxic lung disease
Start Date / End Date : 01-APR-13 / 01-APR-18
Sponsor : Health Research Board (HRB)
Title : Pulmonary arterial hypertension: role of the bone morphogenetic protein antagonists
Start Date / End Date : 01-OCT-12 / 30-SEP-17
Sponsor : Health Research Board (HRB)
Title : Targeting gremlin in the diagnosis and treatment of fibrotic lung disease
Start Date / End Date : 01-MAY-13 / 31-DEC-16
Sponsor : University College Dublin (UCD)
Title : The pathophysiological basis of hypoxic pulmonary hypertension in the mouse: rho kinase dependent vasoconstrictor and structural mechanisms
Start Date / End Date : 01-MAY-12 / 31-OCT-13
Sponsor : University College Dublin Foundation Ltd.
Title : EP Pulmonary Vascular Biology
Start Date / End Date : 01-OCT-11 / 30-SEP-18
Sponsor : University College Dublin Foundation Ltd.
Title : Gremlin in Acute Lung Injury SVAF
Start Date / End Date : 01-DEC-11 / 01-DEC-14
Sponsor : University College Dublin Foundation Ltd.
Title : Gremlin in ALI (ICSI)
Start Date / End Date : 01-OCT-11 / 30-SEP-13
Sponsor : Higher Education Authority (HEA)
Title : PRTLI 5: MolCellBiol - Split Accounts School of MMS
Start Date / End Date : 01-MAR-11 / 31-DEC-16
Sponsor : University College Dublin Foundation Ltd.
Title : Basic mechanisms in human lung disease
Start Date / End Date : 01-AUG-11 / 30-SEP-19
Sponsor : University College Dublin Foundation Ltd.
Title : SVAF CREB responsive genes in acute lung injury
Start Date / End Date : 01-APR-11 / 31-MAR-13
Sponsor : University College Dublin Foundation Ltd.
Title : PVRF: ALI and CREB
Start Date / End Date : 01-NOV-10 / 30-JUN-14
Sponsor : University College Dublin Foundation Ltd.
Title : Intensive-care Medicine
Start Date / End Date : 31-DEC-10 / 30-DEC-13
Sponsor : Health Research Board (HRB)
Title : Signalling pathways that protect against lung damage in the acute respiratory distress syndrome: CREB responsive genes in the lung
Start Date / End Date : 01-JUL-10 / 30-JUN-15
 

Current Postgraduate Students

Liberty Mthunzi, Doctor of Philosophy (PhD)   -   Thesis Supervisor
Siobhan Devlin, Doctor of Philosophy (PhD)   -   Thesis Supervisor