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Researchers at UCD

researcher

Prem Puri

School of Medicine
C/O National Childrens Research Centre
Our Ladys Childrens Hospital
Crumlin
Dublin 12

Tel: 01 4096420
Email: prem.puri@ucd.ie

Biography

Professor Prem Puri is the Newman Clinical Research Professor at the UCD School of Medicine and Medical Science, and President of the National Children¿s Research Centre at Our Lady¿s Children¿s Hospital.  He is currently the President of the World Federation of Associations of Paediatric Surgeons (WOFAPS) FOUNDATION.  He is Past President of the World Federation of Associations of Pediatric Surgeons (WOFAPS), and Past President of the European Paediatric Surgeons Association (EUPSA). He is Editor-in-Chief of Paediatric Surgery International, and also on the Editorial Board of several other journals.  He is a member of the Health Research Board of Ireland.

Professor Puri is Honorary Fellow of a number of prestigious medical and scientific societies, including the American Surgical Association (ASA), American Academy of Paediatrics, American Paediatric Surgical Association, Japanese Association of Paediatric Surgeons, and also Argentinean, Austrian, Canadian, Czech, Croatian, Cuban, Indian, South African and Ukrainian paediatric surgical associations.

Professor Puri is known internationally for his research into underlying mechanisms causing birth defects, and innovative treatments, which have benefited children all over the world. He is a multi award-winning researcher whose previous awards include People of the Year Award in Ireland and the prestigious Denis Browne Gold Medal by the British Association of Paediatric Surgeons and Rehbein Medal by the European Paediatric Surgeons Association for outstanding contribution to paediatric surgery. He has been a visiting professor to many leading universities all over the world, and invited speaker to numerous international scientific meetings. He has published 10 books, 127 chapters in textbooks and over 500 articles in peer-reviewed journals.

Three to four percent of all babies are born with major congenital birth defects, some of which are lethal and most are debilitating with short and long-term implications for the affected children and their families.  In addition, there are other congenital anomalies which become apparent in infancy or childhood and may cause significant impact on individuals and health care systems.  For the majority of congenital malformations, the cause remains unknown.  During the past three decades we have been interested in understanding the underlying mechanisms causing some of the common congenital birth defects, e.g. vesicoureteral reflux, Hirschsprung¿s disease and related disorders, congenital diaphragmatic hernia, VACTERAL Association and Omphalocele. The National Children¿s Research Centre is now recognised internationally as a leading centre for research in the field of Vesicoureteral reflux , Hirschsprung¿s Disease and Congenital Diaphragmatic Hernia.

Awarded ¿Life Time Achievement Award¿ by the World Federation of Associations of Pediatric Surgeons (WOFAPS) in October 2014 for Outstanding Contribution to the Development of Paediatric Surgery Worldwide.  


Publications

Books

Puri, P. and Menezes, M. (2010) Endoscopic Treatment of Vesicoureteral Reflux. : Elsevier Inc. [DOI] [Details]
Holschneider, A.M. and Puri, P. and Homrighausen, L.H. and Meier-Ruge, W. (2008) Intestinal neuronal malformations (IND): Clinical experience and treatment. : Springer Berlin Heidelberg. [DOI] [Details]
Rolle, U. and Puri, P. (2008) Immunohistochemical studies. : Springer Berlin Heidelberg. [DOI] [Details]
Puri, P. (2008) Swenson's procedure. : Springer Berlin Heidelberg. [DOI] [Details]
Puri, P. and Montedonico, S. (2008) Hirschsprung's disease: Clinical features. : Springer Berlin Heidelberg. [DOI] [Details]
Puri, P. and Rolle, U. (2008) Development of the enteric nervous system. : Springer Berlin Heidelberg. [DOI] [Details]
Puri, P. (2008) Megacystis-microcolon-intestinal hypoperistalsis syndrome. : Springer Berlin Heidelberg. [DOI] [Details]
Puri, P. and Montedonico, S. (2008) Pathophysiology of hirschsprung's disease. : Springer Berlin Heidelberg. [DOI] [Details]
Rolle, U. and Puri, P. (2008) NADPH-diaphorase histochemistry. : Springer Berlin Heidelberg. [DOI] [Details]
Murphy, F. and Puri, P. and Hutson, J.M. and Holschneider, A.M. (2006) Incidence and frequency of different types, and classification of anorectal malformations. : Springer Berlin Heidelberg. [DOI] [Details]
Bekhit, E. and Murphy, F. and Puri, P. and Hutson, J.M. (2006) The clinical features and diagnostic guidelines for identification of anorectal malformations. : Springer Berlin Heidelberg. [DOI] [Details]
Puri, P. (2006) Intestinal Neuronal Dysplasia. : Elsevier Inc. [DOI] [Details]

Book Chapters

P Puri (2013) 'Vesicoureteric Reflux' In: L Spitz and A G Coran (eds). Operative Pediatric Surgery. Florida: CRC Press. [Details]
Puri P., Rolle U. ; (2008) 'Development of the Enteric Nervous System' In: Puri P., Rolle U. ; (eds). Hirschsprung¿s Disease and Allied Disorders, 3rd Edition. Germany: Springer. [Details]
Puri P., Montedonico S. ; (2008) 'Pathophysiology of Hirschsprung’s Disease' In: Puri P., Montedonico S. ; (eds). Hirschsprung¿s Disease and Allied Disorders, 3rd Edition. Germany: Springer. [Details]
Puri P., Montedonico S.; (2008) 'Hirschsprung’s Disease: Clinical Features' In: Puri P., Montedonico S.; (eds). Hirschsprung¿s Disease and Allied Disorders, 3rd Edition. Germany: Springer. [Details]
Murphy F., Menezes M., Puri P. ; (2008) 'Enterocolitis Complicating Hirschsprung’s Disease' In: Murphy F., Menezes M., Puri P. ; (eds). Hirschsprung¿s Disease and Allied Disorders, 3rd Edition. Germany: Springer. [Details]
Rolle U., Puri P. ; (2008) 'NADPH – Diaphorase Histochemistry' In: Rolle U., Puri P. ; (eds). Hirschsprung¿s Disease and Allied Disorders, 3rd Edition. Germany: Springer. [Details]
Rolle U., Puri P. ; (2008) 'Immunohistochemical Studies' In: Rolle U., Puri P. ; (eds). Hirschsprung¿s Disease and Allied Disorders, 3rd Edition. Germany: Springer. [Details]
Puri P., Holschneider A.M. ; (2008) 'Intestinal Neuronal Malformations (IND): Clinical Experience and Treatment' In: Puri P., Holschneider A.M. ; (eds). Hirschsprung¿s Disease and Allied Disorders, 3rd Edition. Germany: Springer. [Details]
Puri P.; (2008) 'Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome' In: Puri P.; (eds). Hirschsprung¿s Disease and Allied Disorders, 3rd Edition. Germany: Springer. [Details]
Puri P. ; (2008) 'Swenson’s Procedure' In: Puri P. ; (eds). Hirschsprung¿s Disease and Allied Disorders, 3rd Edition. Germany: Springer. [Details]
Puri P., Mortell A. ; (2007) 'Appendicitis' In: Puri P., Mortell A. ; (eds). Pediatric Surgery and Urology: Long-Term Outcomes, 2nd Edition. New York: Cambridge University Press. [Details]
 

Peer Reviewed Journals

Thompson, J.,Doi, T.,Power, E.,Balasubramanian, I.,Puri, P.,Bannigan, J.; 'Evidence against a direct role for oxidative stress in cadmium-induced axial malformation in the chick embryo'. Toxicol Appl Pharmacol, 243 (33):390-8390. Available Online [Details]
Takahashi, H; Kutasy, B; Pes, L; Paradisi, F; Puri, P (2015) 'Decidual b-carotene-15,15¿-oxygenase-1 and 2 (BCMO1,2) expression is increased in nitrofen model of congenital diaphragmatic hernia'. Pediatric Surgery International, 31 :37-43. [Details]
Kutasy B, Friedmacher F;Pes L;Coyle D;Doi T;Paradisi F;Puri P (2015) 'Antenatal Retinoic Acid Administration Increases Trophoblastic Retinol-Binding Protein Dependent Retinol Transport in the Nitrofen Model of Congenital Diaphragmatic Hernia'. Pediatric Research, . [DOI] [Details]
Coyle D, O'Donnell AM;Corcionivoschi N;Gillick J;Puri P (2015) 'Rho-kinase expression in Hirschsprung's disease'. Pediatric Surgery International, 31 (11):1077-1085. [DOI] [Details]
Zani A, Eaton S;Puri P;Rintala R;Lukac M;Bagolan P;Kuebler JF;Friedmacher F;Hoellwarth ME;Wijnen R;Tovar JA;Pierro A; (2015) 'International Survey on the Management of Congenital Diaphragmatic Hernia'. European Journal of Pediatric Surgery, . [DOI] [Details]
Coyle D, O'Donnell AM;Puri P (2015) 'Altered distribution of small-conductance calcium-activated potassium channel SK3 in Hirschsprung's disease'. Journal of Pediatric Surgery, 50 (10):1659-1664. [DOI] [Details]
Takahashi T, Friedmacher F;Puri P (2015) 'Gene Expression of FRAS1-Related Extracellular Matrix 1 Is Decreased in Nitrofen-Induced Congenital Diaphragmatic Hernia'. European Journal of Pediatric Surgery, . [DOI] [Details]
Friedmacher F, Puri P (2015) 'Rectal suction biopsy for the diagnosis of Hirschsprung's disease: a systematic review of diagnostic accuracy and complications'. Pediatric Surgery International, 31 (9):821-830. [DOI] [Details]
Zimmer J, Puri P (2015) 'Knockout mouse models of Hirschsprung's disease'. Pediatric Surgery International, 31 (9):787-794. [DOI] [Details]
Mc Laughlin D, Puri P (2015) 'Familial Hirschsprung's disease: a systematic review'. Pediatric Surgery International, 31 (8):695-700. [DOI] [Details]
Tomuschat C, Puri P (2015) 'RET gene is a major risk factor for Hirschsprung's disease: a meta-analysis'. Pediatric Surgery International, 31 (8):701-710. [DOI] [Details]
Duess JW, Puri P (2015) 'Syndromic Hirschsprung's disease and associated congenital heart disease: a systematic review'. Pediatric Surgery International, 31 (8):781-785. [DOI] [Details]
Coyle D, Puri P (2015) 'Hirschsprung's disease in children with Mowat-Wilson syndrome'. Pediatric Surgery International, 31 (8):711-717. [DOI] [Details]
Takahashi T, Friedmacher F;Takahashi H;Hofmann AD;Puri P (2015) 'Kif7 expression is decreased in the diaphragmatic and pulmonary mesenchyme of nitrofen-induced congenital diaphragmatic hernia'. Journal of Pediatric Surgery, 50 (6):904-907. [DOI] [Details]
Hofmann AD, Takahashi T;Duess J;Gosemann JH;Puri P (2015) 'Increased expression of activated pSTAT3 and PIM-1 in the pulmonary vasculature of experimental congenital diaphragmatic hernia'. Journal of Pediatric Surgery, 50 (6):908-911. [DOI] [Details]
O'Donnell AM, Coyle D;Puri P (2015) 'Decreased expression of hyperpolarisation-activated cyclic nucleotide-gated channel 3 in Hirschsprung's disease'. World Journal of Gastroenterology, 21 (18):5635-5640. [DOI] [Details]
Hofmann AD, Friedmacher F;Takahashi T;Gosemann JH;Puri P (2015) 'Increased pulmonary vascular expression of receptor for advanced glycation end products (RAGE) in experimental congenital diaphragmatic hernia'. Journal of Pediatric Surgery, 50 (5):746-749. [DOI] [Details]
Stuart HM, Roberts NA;Hilton EN;McKenzie EA;Daly SB;Hadfield KD;Rahal JS;Gardiner NJ;Tanley SW;Lewis MA;Sites E;Angle B;Alves C;Louren¿¿o T;Rodrigues M;Calado A;Amado M;Guerreiro N;Serras I;Beetz C;Varga RE;Silay MS;Darlow JM;Dobson MG;Barton DE;Hunziker M;Puri P;Feather SA;Goodship JA;Goodship TH;Lambert HJ;Cordell HJ; ;Saggar A;Kinali M; ;Lorenz C;Moeller K;Schaefer F;Bayazit AK;Weber S;Newman WG;Woolf AS (2015) 'Urinary tract effects of HPSE2 mutations'. Journal of the American Society of Nephrology : JASN, 26 (4):797-804. [DOI] [Details]
Zani A, Eaton S;Puri P;Rintala R;Lukac M;Bagolan P;Kuebler JF;Hoellwarth ME;Wijnen R;Tovar J;Pierro A; (2015) 'International survey on the management of necrotizing enterocolitis'. European Journal of Pediatric Surgery, 25 (1):27-33. [DOI] [Details]
Takahashi T, Friedmacher F;Takahashi H;Daniel Hofmann A;Puri P (2015) 'Lysyl oxidase expression is decreased in the developing diaphragm and lungs of nitrofen-induced congenital diaphragmatic hernia'. European Journal of Pediatric Surgery, 25 (1):15-19. [DOI] [Details]
Takahashi T, Friedmacher F;Takahashi H;Hofmann AD;Puri P (2015) 'Disruption of copper-dependent signaling pathway in the nitrofen-induced congenital diaphragmatic hernia'. Pediatric Surgery International, 31 (1):31-35. [DOI] [Details]
Takahashi H, Friedmacher F, Fujiwara N, Hofmann A, Puri P. (2014) 'Pulmonary FGF9 gene expression is downregulated during the pseudoglandular stage in nitrofen-induced hypoplastic lungs'. European Journal of Pediatric Surgery, . [DOI] [Details]
Hofmann AD, Takahashi T;Duess JW;Gosemann JH;Puri P (2014) 'Increased pulmonary vascular expression of Kr¿¿ppel-like factor 5 and activated survivin in experimental congenital diaphragmatic hernia'. Pediatric Surgery International, 30 (12):1191-1197. [DOI] [Details]
Friedmacher F, Fujiwara N;Hofmann AD;Takahashi H;Gosemann JH;Puri P (2014) 'Evidence for decreased lipofibroblast expression in hypoplastic rat lungs with congenital diaphragmatic hernia'. Pediatric Surgery International, 30 (10):1023-1029. [DOI] [Details]
Takahashi T, Friedmacher F;Takahashi H;Hofmann AD;Puri P (2014) 'Myogenin gene expression is not altered in the developing diaphragm of nitrofen-induced congenital diaphragmatic hernia'. Pediatric Surgery International, 30 (9):901-906. [DOI] [Details]
Hofmann A, Gosemann JH;Takahashi T;Friedmacher F;Duess JW;Puri P (2014) 'Imbalance of caveolin-1 and eNOS expression in the pulmonary vasculature of experimental diaphragmatic hernia'. Birth Defects Research Part B - Developmental and Reproductive Toxicology, 101 (4):341-346. [DOI] [Details]
Mc Laughlin D, Friedmacher F;Puri P (2014) 'The impact of Clostridium difficile on paediatric surgical practice: a systematic review'. Pediatric Surgery International, 30 (8):853-859. [DOI] [Details]
Duess JW, Hofmann AD;Puri P (2014) 'Prevalence of Hirschsprung's disease in premature infants: a systematic review'. Pediatric Surgery International, 30 (8):791-795. [DOI] [Details]
Hofmann AD, Duess JW;Puri P (2014) 'Congenital anomalies of the kidney and urinary tract (CAKUT) associated with Hirschsprung's disease: a systematic review'. Pediatric Surgery International, 30 (8):757-761. [DOI] [Details]
Coyle D, Friedmacher F;Puri P (2014) 'The association between Hirschsprung's disease and multiple endocrine neoplasia type 2a: a systematic review'. Pediatric Surgery International, 30 (8):751-756. [DOI] [Details]
Friedmacher F, Fujiwara N;Hofmann AD;Takahashi H;Alvarez LA;Gosemann JH;Puri P (2014) 'Prenatal retinoic acid increases lipofibroblast expression in hypoplastic rat lungs with experimental congenital diaphragmatic hernia'. Journal of Pediatric Surgery, 49 (6):876-81. [DOI] [Details]
Hofmann AD, Friedmacher F;Hunziker M;Takahashi H;Duess JW;Gosemann JH;Puri P (2014) 'Upregulation of serotonin-receptor-2a and serotonin transporter expression in the pulmonary vasculature of nitrofen-induced congenital diaphragmatic hernia'. Journal of Pediatric Surgery, 49 (6):871-81. [DOI] [Details]
Hunziker M, Colhoun E;Puri P (2014) 'Renal cortical abnormalities in siblings of index patients with vesicoureteral reflux'. Pediatrics, 133 (4):1-7. [DOI] [Details]
Zani A, Eaton S;Hoellwarth M;Puri P;Tovar J;Fasching G;Bagolan P;Lukac M;Wijnen R;Kuebler J;Cecchetto G;Rintala R;Pierro A (2014) 'Management of pediatric inguinal hernias in the era of laparoscopy: results of an international survey'. European Journal of Pediatric Surgery, 24 (1):9-13. [DOI] [Details]
Zani A, Eaton S;Hoellwarth ME;Puri P;Tovar J;Fasching G;Bagolan P;Lukac M;Wijnen R;Kuebler JF;Cecchetto G;Rintala R;Pierro A (2014) 'International survey on the management of esophageal atresia'. European Journal of Pediatric Surgery, 24 (1):3-8. [DOI] [Details]
Friedmacher F, Fujiwara N;Hofmann AD;Takahashi H;Gosemann JH;Puri P (2014) 'Expression of Eya1 and Six1 is decreased in distal airways of rats with experimental pulmonary hypoplasia'. Journal of Pediatric Surgery, 49 (2):301-304. [DOI] [Details]
Friedmacher F, Hofmann AD;Takahashi H;Takahashi T;Gosemann JH;Puri P (2014) 'Disruption of THY-1 signaling in alveolar lipofibroblasts in experimentally induced congenital diaphragmatic hernia'. Pediatric Surgery International, 30 (2):129-135. [DOI] [Details]
Hofmann AD, Friedmacher F;Takahashi H;Hunziker M;Gosemann JH;Puri P (2014) 'Decreased apelin and apelin-receptor expression in the pulmonary vasculature of nitrofen-induced congenital diaphragmatic hernia'. Pediatric Surgery International, 30 (2):197-203. [DOI] [Details]
Mc Laughlin D, Murphy P;Puri P (2014) 'Altered Tbx1 gene expression is associated with abnormal oesophageal development in the adriamycin mouse model of oesophageal atresia/tracheo-oesophageal fistula'. Pediatric Surgery International, 30 (2):143-149. [DOI] [Details]
Kutasy B, Friedmacher F;Duess JW;Puri P (2014) 'Prenatal administration of retinoic acid increases the trophoblastic insulin-like growth factor 2 protein expression in the nitrofen model of congenital diaphragmatic hernia'. Pediatric Surgery International, 30 (2):137-142. [DOI] [Details]
Darlow JM, Dobson MG;Darlay R;Molony CM;Hunziker M;Green AJ;Cordell HJ;Puri P;Barton DE (2014) 'A new genome scan for primary nonsyndromic vesicoureteric reflux emphasizes high genetic heterogeneity and shows linkage and association with various genes already implicated in urinary tract development'. Molecular genetics & genomic medicine, 2 (1):7-29. [DOI] [Details]
Kutasy, B; Pes, L; Friedmacher, F.; Paradisi, F; Puri, P (2014) 'Nitrofen increases total retinol levels in placenta during lung morphogenesis in the nitrofen model of congenital diaphragmatic hernia'. Pediatric Surgery International, 30 :1017-1022. [Details]
Kutasy, B; Friedmacher, F; Pes, L; Paradisi, F; Puri, P (2014) 'Increased uptake of dietary retinoids at the maternal-fetal barrier in the nitrofen model of congenital diaphragmatic hernia'. Journal of Pediatric Surgery, 49 :866-870. [DOI] [Details]
Gosemann JH, Friedmacher F, Fujiwara N, Alvarez LA, Corcionivoschi N, Puri P. (2013) 'Disruption of the bone morphogenetic protein receptor 2 pathway in nitrofen-induced congenital diaphragmatic hernia'. Birth Defects Research Part B-Developmental And Reproductive Toxicology, 98 (4):304-309. [DOI] [Details]
Balazs Kutasy, Jan H. Gosemann, Johannes W. Duess, Prem Puri (2013) 'Increased trophoblastic apoptosis mediated by neutrophil gelatinase-associated lipocalin (NGAL) activation in the nitrofen model of congenital diaphragmatic hernia'. Pediatric Surgery International, 29 (1):25-31. [DOI] [Details]
Johannes W. Duess, Naho Fujiwara, Nicolae Corcionivoschi, Prem Puri, Jennifer Thompson (2013) 'ROCK inhibitor (Y-27632) disrupts somitogenesis in chick embryos'. Pediatric Surgery International, 29 :13-18. [DOI] [Details]
Naho Fujiwara, Johannes Duess, Prem Puri, Jennifer Thompson (2013) 'Disturbance of SHH signalling pathway during early embryogenesis in the cadmium-induced omphalocele chick model'. Pediatric Surgery International, 29 :165-170. [DOI] [Details]
Florian Friedmacher, Jan-Hendrik Gosemann, Hiromizu Takahashi, Nicolae Corcionivoschi, Prem Puri (2013) 'Decreased pulmonary c-Cbl expression and tyrosine phosphorylation in the nitrofen-induced rat model of congenital diaphragmatic hernia'. Pediatric Surgery International, 29 :19-24. [DOI] [Details]
Dobson MG, Darlow JM, Hunziker M, Green AJ, Barton DE, Puri P. (2013) 'Heterozygous non-synonymous ROBO2 variants are unlikely to be sufficient to cause familial vesicoureteric reflux'. Kidney International, 84 :327-337. [DOI] [Details]
Balazs Kutasy, Prem Puri (2013) 'Appendicitis in obese children'. Pediatric Surgery International, 29 (6). [DOI] [Details]
Dingemann, J,Doi, T,Gosemann, JH,Ruttenstock, EM,Nakazawa, N,Puri, P (2013) 'Decreased Expression of GATA4 in the Diaphragm of Nitrofen-Induced Congenital Diaphragmatic Hernia'. Birth Defects Research Part B: Developmental and Reproductive Toxicology, 98 :139-143. [DOI] [Details]
Hunziker M, Colhoun E, Puri P. (2013) 'Prevalence and predictors of renal functional abnormalities of high grade vesicoureteral reflux'. Journal of Urology, 190 (4):1490-1494. [DOI] [Details]
Gosemann, JH,Friedmacher, F,Hunziker, M,Alvarez, L,Corcionivoschi, N,Puri, P (2013) 'Increased activation of NADPH oxidase 4 in the pulmonary vasculature in experimental diaphragmatic hernia'. Pediatric Surgery International, 29 :3-8. [DOI] [Details]
Hunziker M, Mohanan N, Puri P. (2012) 'Dextranomer/Hyaluronic Acid Endoscopic Injection is Effective in the Treatment of Intermediate and High Grade Vesicoureteral Reflux in Patients with Complete Duplex Systems'. Journal of Urology, 189 (5):1876-1881. [Details]
Shinkai, T,Shinkai, M,Pirker, MA,Montedonico, S,Puri, P; (2011) 'Spatial and temporal patterns of c-kit positive cells in embryonic lungs'. Pediatric Surgery International, 27 :181-185. [DOI] [Details]
Doi, T,Shintaku, M,Dingemann, J,Ruttenstock, E,Puri, P; (2011) 'Downregulation of Midkine gene expression and its response to retinoic acid treatment in the nitrofen-induced hypoplastic lung'. Pediatric Surgery International, 27 :199-204. [DOI] [Details]
Ruttenstock, EM,Doi, T,Dingemann, J,Puri, P; (2011) 'Prenatal retinoic acid treatment upregulates late gestation lung protein 1 in the nitrofen-induced hypoplastic lung in late gestation'. Pediatric Surgery International, 27 :125-129. [DOI] [Details]
Doi, T,Puri, P,Bannigan, J,Thompson, J; (2011) 'Pre-treatment with N-acetylcysteine upregulates superoxide dismutase 2 and catalase genes in cadmium-induced oxidative stress in the chick omphalocele model'. Pediatric Surgery International, 27 :131-136. [DOI] [Details]
Ruttenstock, EM,Doi, T,Dingemann, J,Puri, P; (2011) 'IGFBP-4 Gene Overexpression in the Nitrofen-Induced Hypoplastic Lung'. Pediatrics, 21 :42-45. [DOI] [Details]
Doi, T,Lukosiute, A,Ruttenstock, E,Dingemann, J,Puri, P; (2011) 'Expression of Iroquois genes is up-regulated during early lung development in the nitrofen-induced pulmonary hypoplasia'. Journal of Pediatric Surgery, 46 :62-66. [DOI] [Details]
Doi, T,Sugimoto, K,Ruttenstock, E,Dingemann, J,Puri, P; (2011) 'Prenatal treatment with retinoic acid activates parathyroid hormone-related protein signaling in the nitrofen-induced hypoplastic lung'. Pediatric Surgery International, 27 :47-52. [DOI] [Details]
Doi, T,Puri, P,McCann, A,Bannigan, J,Thompson, J; (2011) 'Epigenetic Effect of Cadmium on Global De Novo DNA Hypomethylation in the Cadmium-Induced Ventral Body Wall Defect (VBWD) in the Chick Model'. Toxicological sciences : an official journal of the Society of Toxicology, 120 :475-480. [DOI] [Details]
Ruttenstock, E,Doi, T,Dingemann, J,Puri, P; (2011) 'Prenatal Administration of Retinoic Acid Upregulates Insulin-Like Growth Factor Receptors in the Nitrofen-Induced Hypoplastic Lung'. Toxicology, 92 :148-151. [DOI] [Details]
Doi, T,Puri, P,Bannigan, J,Thompson, J; (2011) 'Altered PITX2 and LEF1 gene expression in the cadmium-induced omphalocele in the chick model'. Pediatric Surgery International, 27 :495-499. [DOI] [Details]
Doi, T,Puri, P,Bannigan, J,Thompson, J; (2011) 'BMPR1A-mediated BMP1 signalling is disrupted in the cadmium-induced omphalocele in the chick model'. Pediatric Surgery International, 27 :617-621. [DOI] [Details]
Ruttenstock, EM,Doi, T,Dingemann, J,Puri, P; (2011) 'Prenatal administration of retinoic acid upregulates connective tissue growth factor in the nitrofen CDH model'. Pediatric Surgery International, 27 :573-577. [DOI] [Details]
Doi, T,Puri, P,Bannigan, J,Thompson, J; (2011) 'Disruption of GLI3-ZIC3 interaction in the cadmium-induced omphalocele chick model'. Pediatric Surgery International, 27 :205-209. [DOI] [Details]
Doi, T,Puri, P,Bannigan, J,Thompson, J; (2011) 'Alteration of gene expression of IQGAP1 and Rho-family GTPases in the cadmium-induced ventral body wall defects in the chick model'. Reproductive Toxicology, 32 :124-128. [DOI] [Details]
Dingemann, J,Doi, T,Ruttenstock, E,Puri, P; (2011) 'Expression of the Wilm's tumor gene WT1 during diaphragmatic development in the nitrofen model for congenital diaphragmatic hernia'. Pediatric Surgery International, 27 :159-163. [DOI] [Details]
Dingemann, J,Doi, T,Ruttenstock, E,Puri, P; (2011) 'The role of primary myogenic regulatory factors in the developing diaphragmatic muscle in the nitrofen-induced diaphragmatic hernia'. Pediatric Surgery International, 27 :579-582. [DOI] [Details]
Dingemann, J,Doi, T,Ruttenstock, E,Puri, P; (2010) 'Upregulation of Endothelin Receptors A and B in the nitrofen induced hypoplastic lung occurs early in gestation'. Pediatric Surgery International, 26 :65-69. [DOI] [Details]
Hunziker M, Mohanan N, Menezes M, Puri P.; (2010) 'Prevalence of duplex collecting systems in familial vesicoureteral reflux'. Pediatr Surg Int, 26 (1):115-117. [Details]
Doi T, Ruttenstock E, Dingemann J, Puri P.; (2010) 'Spatiotemporal alteration in phosphatidylinositide 3-kinase-serine/threonine protein kinase B signaling in the nitrofen-induced hypoplastic lung'. J Pediatr Surg, 45 (2):366-371. [Details]
Hajduk P, Murphy P, Puri P.; (2010) 'Mesenchymal expression of Tbx4 gene is not altered in Adriamycin mouse model'. Pediatr Surg Int, 26 (4):407-411. [Details]
Kutasy B, Laxamanadass G, Puri P.; (2010) 'Is C-reactive protein a reliable test for suspected appendicitis in extremely obese children?'. Pediatr Surg Int, 26 (1):123-125. [Details]
Puri P.; (2010) 'The 22nd international symposium on paediatric surgical research'. Pediatr Surg Int, 26 (1):1. [Details]
Keijzer R, Puri P.; (2010) 'Congenital diaphragmatic hernia'. Semin Pediatr Surg, 19 (3):180-185. [Details]
Doi T, Puri P, Bannigan J, Thompson J.; (2010) 'Msx1 and Msx2 gene expression is downregulated in the cadmium-induced omphalocele in the chick model'. J Pediatr Surg, 45 (6):1187-1191. [Details]
Ruttenstock E, Doi T, Dingemann J, Puri P.; (2010) 'Insulin receptor is downregulated in the nitrofen-induced hypoplastic lung'. J Pediatr Surg, 45 (5):948-952. [Details]
Doi T, Puri P, Bannigan J, Thompson J.; (2010) 'The role of transforming growth factor-beta 2 and 3 in formation of ventral body wall in the cadmium-induced omphalocele chick model'. J Pediatr Surg, 45 (5):989-902. [Details]
Kutasy B, Hunziker M, Laxamanadass G, Puri P.; (2010) 'Increased incidence of negative appendectomy in childhood obesity'. Pediatr Surg Int, . [Details]
Hunziker M, Mohanan N, D'Asta F, Puri P.; (2010) 'Endoscopic treatment of primary grade V vesicoureteral reflux using hyaluronic acid copolymer (DX/HA)'. Pediatr Surg Int, . [Details]
Doi T, Puri P, Bannigan J, Thompson J.; (2010) 'HoxB2, HoxB4 and Alx4 genes are downregulated in the cadmium-induced omphalocele in the chick model'. Pediatr Surg Int, . [Details]
Doi T, Sugimoto K, Ruttenstock E, Dingemann J, Puri P.; (2010) 'Prenatal retinoic acid upregulates pulmonary gene expression of PI3K and AKT in nitrofen-induced pulmonary hypoplasia'. Pediatr Surg Int, . [Details]
Ruttenstock E, Doi T, Dingemann J, Puri P.; (2010) 'Insulinlike growth factor receptor type 1 and type 2 are downregulated in the nitrofen-induced hypoplastic lung'. J Pediatr Surg, 45 (6):1349-1353. [Details]
Hajduk P, Murphy P, Puri P.; (2010) 'Fgf10 gene expression is delayed in the embryonic lung mesenchyme in the adriamycin mouse model'. Pediatr Surg Int, . [Details]
Doi T, Puri P, Bannigan J, Thompson J.; (2010) 'Disruption of noncanonical Wnt/CA2+ pathway in the cadmium-induced omphalocele in the chick model'. Journal of Pediatric Surgery, 45 (8):1645-1649. [Details]
O'Donnell AM, Puri P.; (2010) 'The development of excitatory neurons in the chick cloaca'. Pediatr Surg Int, 26 (1):111-114. [Details]
Thompson J, Doi T, Power E, Balasubramanian I, Puri P, Bannigan J; (2010) 'Evidence against a direct role for oxidative stress in cadmium-induced axial malformation in the chick embryo'. Toxicology and Applied Pharmacology, 243 (3):390-398. [DOI] [Details]
Ruttenstock, E,Doi, T,Dingemann, J,Puri, P; (2010) 'Downregulation of insulin-like growth factor binding protein 3 and 5 in nitrofen-induced pulmonary hypoplasia'. Pediatric Surgery International, 26 :59-63. [DOI] [Details]
Doi, T,Lukosiute, A,Ruttenstock, E,Dingemann, J,Puri, P; (2010) 'Disturbance of parathyroid hormone-related protein signaling in the nitrofen-induced hypoplastic lung'. Pediatric Surgery International, 26 :45-50. [DOI] [Details]
Takayasu, H,Murphy, P,Sato, H,Doi, T,Puri, P; (2010) 'Embryonic Wnt gene expression in the nitrofen-induced hypoplastic lung using 3-dimensional imaging'. Journal of Pediatric Surgery, 45 :2129-2135. [DOI] [Details]
Dingemann, J,Puri, P; (2010) 'Isolated hypoganglionosis: systematic review of a rare intestinal innervation defect'. Pediatric Surgery International, 26 :1111-1115. [DOI] [Details]
Doodnath, R,Puri, P; (2010) 'A systematic review and meta-analysis of Hirschsprung's disease presenting after childhood'. Pediatric Surgery International, 26 :1107-1110. [DOI] [Details]
Dingemann, J,Doi, T,Ruttenstock, E,Puri, P; (2010) 'Abnormal platelet-derived growth factor signaling accounting for lung hypoplasia in experimental congenital diaphragmatic hernia'. Journal of Pediatric Surgery, 45 :1989-1994. [DOI] [Details]
Doi, T,Sugimoto, K,Ruttenstock, E,Dingemann, J,Puri, P; (2010) 'Prenatal retinoic acid upregulates pulmonary gene expression of PI3K and AKT in nitrofen-induced pulmonary hypoplasia'. Pediatric Surgery International, 26 :1011-1015. [DOI] [Details]
Doi, T,Puri, P,Bannigan, J,Thompson, J; (2010) 'HoxB2, HoxB4 and Alx4 genes are downregulated in the cadmium-induced omphalocele in the chick model'. Pediatric Surgery International, 26 :1017-1023. [DOI] [Details]
Doi, T,Puri, P,Bannigan, J,Thompson, J; (2010) 'Disruption of calreticulin-mediated cellular adhesion signaling in the cadmium-induced omphalocele in the chick model'. Pediatric Surgery International, 26 :91-95. [DOI] [Details]
Oberritter, Z,Rolle, U,Juhasz, Z,Cserni, T,Puri, P; (2009) 'Altered expression of c-kit-positive cells in the ureterovesical junction after surgically created vesicoureteral reflux'. Pediatric Surgery International, 25 :1103-1107. [DOI] [Details]
Ruttenstock E, Puri P.; (2009) 'A meta-analysis of clinical outcome in patients with total intestinal aganglionosis'. Pediatr Surg Int, 25 (10):833-839. [Details]
O'Donnell, A. M.,Puri, P.; (2009) 'Cholinergic innervation in the developing chick cloaca and colorectum'. J Pediatr Surg, 44 (2):392-4. Available Online [Details]
Cserni, T.,O' Donnel A,Paran, S.,Puri, P.; (2009) 'Correlation of enteric NADPH-d positive cell counts with the duration of incubation period in NADPH-d histochemistry'. Pathol Oncol Res, 15 (1):103-7. Available Online [Details]
 

Conference Publications

Dawrant, M., Giles, S., Bannigan, J. Puri, P.; (2006) Abnormal separation of the respiratory primordium in the Adriamycin mouse model British Association of Paediatric Surgeons 53rd Annual International Congress [Details]
O'Donnell, A.M., Montedonico, S., Bannigan, J. Puri, P.; (2006) Differences in nitrergic innervation of the developing chick cloaca and colorectum Development of the Enteric Nervous System [Details]
O'Donnell, A.M., Bannigan, J. Puri, P.; (2006) Vagal contribution to the chick embryo cloaca 13th International Paediatric Colorectal Club [Details]
O'Donnell, A.M., Bannigan, J. Puri, P.; (2006) Vagal neural crest contribution to the chick embryo cloaca 7th European Congress of Paediatric Surgery [Details]
Dawrant, M., Giles, S., Bannigan, J. Puri, P.; (2005) Defining the extent of anomalies in the adriamycin mouse model 37th Annual Meeting of the Canadian Association of Paediatric Surgeons [Details]
O'Donnell, A.M., Montedonico, S., Bannigan, J. Puri, P.; (2005) Differences in nitrergic innervation of the developing chick cloaca and colorectum 18th International Symposium of Paediatric Surgical Research [Details]
   

Editorial

Puri P (2014) The 27th International Symposium on Paediatric Surgical Research. Editorial [DOI] [Details]
Prem Puri (2013) The 25th International Symposium on paediatric surgical research. Editorial [Details]
                 

Abstract

Puri, P (2010) NON OPERATIVE MANAGEMENT OF APPENDIX MASS IN CHILDREN. Abstract [Details]
Barton, DE,Kelly, H,Yoneda, A,Darlow, JM,Shields, D,Molony, C,Puri, P (2006) A genome-wide scan for genes involved in vesicoureteral reflux. Abstract [Details]
Ennis, S,Bermingham, C,Kelly, H,Yoneda, A,Kelly, S,Shields, D,Molony, C,Green, AJ,Puri, P,Barton, DE (2001) Exclusion of the candidate gene Uroplakin III in primary vesicoureteral reflux. Abstract [Details]
Yoneda, A,Kelly, S,Shields, D,Molony, C,Green, AJ,Puri, P,Barton, DE (2001) No evidence for a role for the angiotensin II, type 2 receptor in primary vesicoureteral reflux. Abstract [Details]
       

Reviews

Gosemann, JH,Puri, P (2011) Megacystis microcolon intestinal hypoperistalsis syndrome: systematic review of outcome. Reviews [DOI] [Details]
Paran, TS,Rolle, U,Puri, P (2006) Enteric nervous system and developmental abnormalities in childhood. Reviews [DOI] [Details]
Sweeney, B,Puri, P,Reen, DJ (2005) Modulation of immune cell function by polyunsaturated fatty acids. Reviews [DOI] [Details]
Chertin, B,Puri, P (2003) Familial vesicoureteral reflux. Reviews [DOI] [Details]
                                                     

Research

Research Interests

Investigating mechanisms causing some of the common congenital birth defects such as Vesicoureteral reflux, Hirschsprung¿s disease, congenital diaphragmatic hernia and oesophageal atresia