Navigation

Researchers at UCD

researcher

Walter Kolch

Director System Biology Ireland

Systems Biology Ireland
Belfield Campus
Dublin 4

Tel: +353 1 7166303
Email: walter.kolch@ucd.ie

Biography

Walter Kolch is Director of Systems Biology Ireland (SBI) at University College Dublin (UCD). A leading international proponent of precision medicine, Kolch originally trained as a clinician, subsequently working in the pharmaceutical industry, research institutes, and academia. He is internationally recognised for his cutting-edge research using systems approaches to understand signalling networks, and is ranked 3rd in the world in precision medicine, 8th in personalised medicine, and amongst the world¿s top 50 in proteomics, systems biology, and signal Transduction (Google Scholar). Through his leading involvement in pan-European strategic initiatives including Coordinating Action Systems Medicine, Infrastructure for Systems Biology Europe, and the ELIXIR research infrastructure for life science information, Kolch has played a central role in the development of precision medicine policy and funding at both national and international level.

Kolch has designed, developed and coordinated innovative systems biology, systems medicine and precision medicine programmes of vision, scale and impact throughout his career, with a track record of competitive grant funding of over ¿200M. Kolch founded the Sir Henry Wellcome Functional Genomics Facility in 2001 - one of the first facilities worldwide that integrated genomics, transcriptomics, proteomics and bioinformatics under one roof pioneering multi-omics data integration.  From 2005 to 2009, he was Scientific Director of the Interdisciplinary Research Collaboration (IRC) Proteomics Technologies - RASOR, a £15M multidisciplinary project between the Universities of Glasgow, Edinburgh, Strathclyde and Dundee, which focused on developing innovative proteomics technologies. RASOR produced >180 publications, 6 patents and a spin out company. It also incorporated an associated doctoral training centre. In 2009, he established SBI, a ¿22M interdisciplinary research centre focusing on the design of new diagnostic and therapeutic approaches to diseases primarily cancer, based on a systems level, mechanistic understanding of cellular signal transduction networks. An independent review of 2017 ranked SBI as one of the top four research centres that integrate computational modelling with experimental cell biology.

Kolch¿s record of coordinating large scale interdisciplinary initiatives includes one EU Horizon 2020 MSCA training programme, two EU-FP7 health programmes and two large strategic UK Biotechnology and Biological Sciences Research Council (BBSRC)/Engineering and Physical Sciences Research Council (EPSRC) funded cross-University research collaborations. He has also partnered on 10 EU-FP6/FP7 programmes.

His current interest is focusing on using computational modelling and omics approaches to  analyse biological networks in order to elucidate the molecular mechanisms of disease such as cancer and inflammation (skin, rheumatoid arthritis), and in order to design new approaches to personalised diagnostics and treatment of these disease based on a systems level, molecular mechanistic understanding.

Professional

Honours and Awards

Year: 2016.
Title: Elelected Member of the Royal Irish Academy
Year: 2006.
Title: Elected Fellow of the Royal Society of Edinburgh

Associations

Association: IEET Systems Biology, Function/Role: Editor in Chief
Association: Systems Biology Advisory Committee, German Federal Ministry for Education and Research, Function/Role: Chairman
Association: Systems Biology Institute, Yale, Function/Role: Memebr, Scientific Advisory Board
Association: Centre for Genome Regulation, Barcelona, Function/Role: Member of Scientific Advisory Board
Association: Mosaiques, Function/Role: Member of Scientific Advisory Board
Association: International Receptor Tyrosine Kinase Consortium , Function/Role: Member, Executive Committee
Association: Caledonian Research Foundation (2007-2010), Function/Role: Director
Association: British Society for Proteome Research , Function/Role: President
         

Employment

Employer: University College Dublin
Position: Director, Conway Institute
Employer: University College Dublin
Position: Director, Systems Biology Ireland
Employer: Proteomics Technologies
Position: Scientific Director, Interdisciplinary Research Collaboration
Employer: University of Glasgow, UK
Position: Director, Sir Henry Wellcome Functional Genomics Facility
Employer: University of Glasgow, UK
Position: Professor of Molecular Cell Biology
Employer: Beatson Institute for Cancer Research, Glasgow, UK
Position: Group Leader
Employer: GSF Research Centre, Munich, Germany
Position: Head of the Signal Transduction Group
Employer: Gödecke-Parke Davis, Freiburg, Germany
Position: Head of the Department of Molecular Biology
Employer: Ibidem
Position: Fogarty Visiting Fellow
Employer: National Cancer Institute / National Institutes of Health, Frederick, Maryland, USA
Position: Erwin Schrödinger Fellow from the Austrian Science Foundation
Employer: Institute of Biochemistry, University of Vienna, Austria
Position: Research Assistant

Education

Year 1985 Institution: University of Vienna, Austria
Qualification: MD Subject:
Year 1996 Institution: Ludwig-Maximilians U Munich. DE
Qualification: HABILITATION Subject:
       

Other Activities

  Invited Speaker: 61 seminars, 86 conferences including 22 plenary / keynote lectures (January 2004-September 2016).

Publications

 

Book Chapters

Pitt, A., Kolch, W. (2014) 'Regulation of Gene Expression, Genomics, Proteomics and Metabolomics' In: Medical Biochemistry. , pp.466-485 [Details]
Fey, D; Croucher, DR; Kolch, W; Kholodenko, BN (2012) 'Understanding Cell Fate Decisions by Identifying Crucial System Dynamics' In: D'Onofrio, A; Cerrai, P; Gandolfi, A (eds). New Challenges for Cancer Systems Biomedicine, SIMAI Springer Series. Heidelberg: Springer. , pp.83-104 [Details]
Hagan, S., Garcia, R., Dhillon, A., Kolch, W., Balch, W., Der, C. J., Hall, A. (2006) 'Raf Kinased Inhibitor Protein Regulation of Raf and MAPK Signaling' In: Methods in Enzymology. Elsevier. , pp.248-258 [Details]
Wolkenhauer, O., Kolch, W., Cho, K. H., Paton, R. (2004) 'Mathematical Systems Biology: Genomic Cybernetics' In: Computations in Cells and Tissues: Perspectives and Tools of Thought. Springer Verlag. , pp.305-326 [Details]
Wolkenhauer, O., Kolch, W., Cho, K. H., Gauges, R., Kummer, U., Pahle, J., Rost, U. (2004) 'Dynamic Pathway Modelling: from models to cells' In: Proceeding of the 3rd Workshop on Computation of Biochemical Pathways and Genetic Networks. Logos Verlag Berlin. , pp.79-89 [Details]
Cho, K. H., Shin, S. Y., Kim, H. W., Wolkenhauer, O., McFerran, B., Kolch, W., Priami, C., Goos, G., Hartmanis, J., van Leeuwen, J. (2003) 'Mathematical Modelling of the Influence of RKIP on the ERK Signalling Pathway' In: Computational Methods in Systems Biology. Springer Verlag. , pp.127-141 [Details]
Garcia, R., Dhillon, A. S., Kolch, W., Pandalai, S. G. (2002) 'Raf kinases: A small family with wide ramifications' In: Research Signpost. , pp.88-112 [Details]
Kolch, W., Cleveland, J. L., Rapp, U. (1990) 'Role of oncogenes in the abrogation of growth factor requirements of hemopoetic cells' In: , pp.279-303 [Details]
Heidecker, G., Cleveland, J. L., Beck, T. W., Huleihel, M., Kolch, W., Storm, S., Rapp, U., Colburn.N, (1989) 'Role of raf and myc oncogenes in signal transduction' In: Genes and Signal Transduction in Multistage Carcinogenesis. M. Dekker. , pp.339-374 [Details]
 

Peer Reviewed Journals

Daly C, Shine L, Heffernan T, Deeti S, Reynolds AL, O'Connor JJ, Dillon ET, Duffy DJ, Kolch W, Cagney G, Kennedy BN (2017) 'A Brain-Derived Neurotrophic Factor Mimetic Is Sufficient to Restore Cone Photoreceptor Visual Function in an Inherited Blindness Model'. Scientific Reports, . [DOI] [Details]
Radic-Sarikas, B; Halasz, M; Huber, KVM; Winter, GE; Tsafou, KP; Papamarkou, T; Brunak, S; Kolch, W; Superti-Furga, G (2017) 'Lapatinib potentiates cytotoxicity of YM155 in neuroblastoma via inhibition of the ABCB1 efflux transporter'. Scientific Reports, 7 (1):3091. Available Online [DOI] [Details]
Sithanandam, G., Kolch, W., Duh, F. M., Rapp, U. R. (1990) 'Complete coding sequence of a human B-raf cDNA and detection of B-raf protein kinase with isozyme specific antibodies'. Oncogene, 5 (12):1775-80. [Details]
Mischak, H., Kolch, W., Hofer, F., Weissinger, E., Gessl, A., Davidson, W. F., Aiello, F. B., Blaas, D., Rapp, U. R. (1990) 'A raf/myc virus immortalized macrophage cell line which supports the growth of B-cell and B-cell hybridomas'. Oncogene, 5 (9):1377-82. [Details]
Heidecker, G., Huleihel, M., Cleveland, J. L., Kolch, W., Beck, T. W., Lloyd, P., Pawson, T., Rapp, U. R. (1990) 'Mutational activation of c-raf-1 and definition of the minimal transforming sequence'. Mol Cell Biol, 10 (6):2503-12. [Details]
Qureshi, S. A., Rim, M., Bruder, J., Kolch, W., Rapp, U., Sukhatme, V. P., Foster, D. A. (1991) 'An inhibitory mutant of c-Raf-1 blocks v-Src-induced activation of the Egr-1 promoter'. J Biol Chem, 266 (31):20594-7. [Details]
Mischak, H., Kolch, W., Goodnight, J., Davidson, W. F., Rapp, U., Rose-John, S., Mushinski, J. F. (1991) 'Expression of protein kinase C genes in hemopoietic cells is cell-type- and B cell-differentiation stage specific'. J Immunol, 147 (11):3981-7. [Details]
Heidecker, G., Kolch, W., Morrison, D. K., Rapp, U. R. (1992) 'The role of Raf-1 phosphorylation in signal transduction'. Adv Cancer Res, 58 :53-73. [Details]
Mischak, H., Goodnight, J. A., Kolch, W., Martiny-Baron, G., Schaechtle, C., Kazanietz, M. G., Blumberg, P. M., Pierce, J. H., Mushinski, J. F. (1993) 'Overexpression of protein kinase C-delta and -epsilon in NIH 3T3 cells induces opposite effects on growth, morphology, anchorage dependence, and tumorigenicity'. J Biol Chem, 268 (9):6090-6. [Details]
Kolch, W., Heidecker, G., Troppmair, J., Yanagihara, K., Bassin, R. H., Rapp, U. R. (1993) 'Raf revertant cells resist transformation by non-nuclear oncogenes and are deficient in the induction of early response genes by TPA and serum'. Oncogene, 8 (2):361-70. [Details]
Kolch, W., Heidecker, G., Kochs, G., Hummel, R., Vahidi, H., Mischak, H., Finkenzeller, G., Marme, D., Rapp, U. R. (1993) 'Protein kinase C alpha activates RAF-1 by direct phosphorylation'. Nature, 364 (6434):249-52. [Details]
Moodie, S. A., Paris, M. J., Kolch, W., Wolfman, A. (1994) 'Association of MEK1 with p21ras.GMPPNP is dependent on B-Raf'. Mol Cell Biol, 14 (11):7153-62. [Details]
Hafner, S., Adler, H. S., Mischak, H., Janosch, P., Heidecker, G., Wolfman, A., Pippig, S., Lohse, M., Ueffing, M., Kolch, W. (1994) 'Mechanism of inhibition of Raf-1 by protein kinase A'. Mol Cell Biol, 14 (10):6696-703. [Details]
Li, S., Janosch, P., Tanji, M., Rosenfeld, G. C., Waymire, J. C., Mischak, H., Kolch, W., Sedivy, J. M. (1995) 'Regulation of Raf-1 kinase activity by the 14-3-3 family of proteins'. EMBO J, 14 (4):685-96. [Details]
Goodnight, J. A., Mischak, H., Kolch, W., Mushinski, J. F. (1995) 'Immunocytochemical localization of eight protein kinase C isozymes overexpressed in NIH 3T3 fibroblasts. Isoform-specific association with microfilaments, Golgi, endoplasmic reticulum, and nuclear and cell membranes'. J Biol Chem, 270 (17):9991-10001. [Details]
Kieser, A., Seitz, T., Adler, H. S., Coffer, P., Kremmer, E., Crespo, P., Gutkind, J. S., Henderson, D. W., Mushinski, J. F., Kolch, W., Mischak, H. (1996) 'Protein kinase C-zeta reverts v-raf transformation of NIH-3T3 cells'. Genes Dev, 10 (12):1455-66. [Details]
Janosch, P., Schellerer, M., Seitz, T., Reim, P., Eulitz, M., Brielmeier, M., Kolch, W., Sedivy, J. M., Mischak, H. (1996) 'Characterization of IkappaB kinases. IkappaB-alpha is not phosphorylated by Raf-1 or protein kinase C isozymes, but is a casein kinase II substrate'. J Biol Chem, 271 (23):13868-74. [Details]
Eissner, G., Lindner, H., Behrends, U., Kolch, W., Hieke, A., Klauke, I., Bornkamm, G. W., Holler, E. (1996) 'Influence of bacterial endotoxin on radiation-induced activation of human endothelial cells in vitro and in vivo: protective role of IL-10'. Transplantation, 62 (6):819-27. [Details]
Cacace, A. M., Ueffing, M., Philipp, A., Han, E. K., Kolch, W., Weinstein, I. B. (1996) 'PKC epsilon functions as an oncogene by enhancing activation of the Raf kinase'. Oncogene, 13 (12):2517-26. [Details]
Ueffing, M., Lovric, J., Philipp, A., Mischak, H., Kolch, W. (1997) 'Protein kinase C-epsilon associates with the Raf-1 kinase and induces the production of growth factors that stimulate Raf-1 activity'. Oncogene, 15 (24):2921-7. [Details]
Kieser, A., Kilger, E., Gires, O., Ueffing, M., Kolch, W., Hammerschmidt, W. (1997) 'Epstein-Barr virus latent membrane protein-1 triggers AP-1 activity via the c-Jun N-terminal kinase cascade'. EMBO J, 16 (21):6478-85. [Details]
Rose, D. W., Xiao, S., Pillay, T. S., Kolch, W., Olefsky, J. M. (1998) 'Prolonged vs transient roles for early cell cycle signaling components'. Oncogene, 17 (7):889-99. [Details]
Prouty, S. M., Maroo, A., Maucher, C., Mischak, H., Kolch, W., Sedivy, J. M. (1998) 'Studies of perinuclear and nuclear translocation of the Raf-1 protein in rodent fibroblasts'. Biochim Biophys Acta, 1402 (1):6-16. [Details]
Maucher, C., Weissinger, E. M., Kremmer, E., Baccarini, M., Procyk, K., Henderson, D. W., Wolff, L., Kolch, W., Kaspers, B., Mushinski, J. F., Mischak, H. (1998) 'Activation of bcl-2 suppressible 40 and 44 kDa p38-like kinases during apoptosis of early and late B lymphocytic cell lines'. FEBS Lett, 427 (1):29-35. [Details]
Lovric, J., Dammeier, S., Kieser, A., Mischak, H., Kolch, W. (1998) 'Activated raf induces the hyperphosphorylation of stathmin and the reorganization of the microtubule network'. J Biol Chem, 273 (35):22848-55. [Details]
Yeung, K., Seitz, T., Li, S., Janosch, P., McFerran, B., Kaiser, C., Fee, F., Katsanakis, K. D., Rose, D. W., Mischak, H., Sedivy, J. M., Kolch, W. (1999) 'Suppression of Raf-1 kinase activity and MAP kinase signalling by RKIP'. Nature, 401 (6749):173-7. [Details]
Vichi, P., Whelchel, A., Knot, H., Nelson, M., Kolch, W., Posada, J. (1999) 'Endothelin-stimulated ERK activation in airway smooth-muscle cells requires calcium influx and Raf activation'. Am J Respir Cell Mol Biol, 20 (1):99-105. [Details]
Kolch, W. (2000) 'Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions'. Biochem J, 351 Pt 2 :289-305. [Details]
Houslay, M. D., Kolch, W. (2000) 'Cell-type specific integration of cross-talk between extracellular signal-regulated kinase and cAMP signaling'. Mol Pharmacol, 58 (4):659-68. [Details]
Dammeier, S., Lovric, J., Eulitz, M., Kolch, W., Mushinski, J. F., Mischak, H. (2000) 'Identification of the smooth muscle-specific protein, sm22, as a novel protein kinase C substrate using two-dimensional gel electrophoresis and mass spectrometry'. Electrophoresis, 21 (12):2443-53. [Details]
Baumann, M., Gires, O., Kolch, W., Mischak, H., Zeidler, R., Pich, D., Hammerschmidt, W. (2000) 'The PKC targeting protein RACK1 interacts with the Epstein-Barr virus activator protein BZLF1'. Eur J Biochem, 267 (12):3891-901. [Details]
Yeung, K. C., Rose, D. W., Dhillon, A. S., Yaros, D., Gustafsson, M., Chatterjee, D., McFerran, B., Wyche, J., Kolch, W., Sedivy, J. M. (2001) 'Raf kinase inhibitor protein interacts with NF-kappaB-inducing kinase and TAK1 and inhibits NF-kappaB activation'. Mol Cell Biol, 21 (21):7207-17. [Details]
Kolch, W. (2001) 'To be or not to be: a question of B-Raf?'. Trends Neurosci, 24 (9):498-500. [Details]
Kao, S., Jaiswal, R. K., Kolch, W., Landreth, G. E. (2001) 'Identification of the mechanisms regulating the differential activation of the mapk cascade by epidermal growth factor and nerve growth factor in PC12 cells'. J Biol Chem, 276 (21):18169-77. [Details]
Dhillon, A. S., Meikle, S., Yazici, Z., Eulitz, M., Kolch, W. (2002) 'Regulation of Raf-1 activation and signalling by dephosphorylation'. EMBO J, 21 (1-2):64-71. [Details]
Dhillon, A. S., Kolch, W. (2002) 'Untying the regulation of the Raf-1 kinase'. Arch Biochem Biophys, 404 (1):3-9. [Details]
Dartsch, D. C., Schaefer, A., Boldt, S., Kolch, W., Marquardt, H. (2002) 'Comparison of anthracycline-induced death of human leukemia cells: programmed cell death versus necrosis'. Apoptosis, 7 (6):537-48. [Details]
Kirchner S, Boldt S;Kolch W;Haffner S;Kazak S;Janosch P;Holler E;Andreesen R;Eissner G (2004) 'LPS resistance in monocytic cells caused by reverse signaling through transmembrane TNF (mTNF) is mediated by the MAPK/ERK pathway'. Journal of Leukocyte Biology, 75 (2):324-331. [DOI] [Details]
O'Neill, E., Rushworth, L., Baccarini, M., Kolch, W. (2004) 'Role of the kinase MST2 in suppression of apoptosis by the proto-oncogene product Raf-1'. Science, 306 (5705):2267-70. [Details]
Neuhoff, Nv, Kaiser, T., Wittke, S., Krebs, R., Pitt, A., Burchard, A., Sundmacher, A., Schlegelberger, B., Kolch, W., Mischak, H. (2004) 'Mass spectrometry for the detection of differentially expressed proteins: a comparison of surface-enhanced laser desorption/ionization and capillary electrophoresis/mass spectrometry'. Rapid Commun Mass Spectrom, 18 (2):149-56. [Details]
Wittke, S., Mischak, H., Walden, M., Kolch, W., Radler, T., Wiedemann, K. (2005) 'Discovery of biomarkers in human urine and cerebrospinal fluid by capillary electrophoresis coupled to mass spectrometry: towards new diagnostic and therapeutic approaches'. Electrophoresis, 26 (7-8):1476-87. [Details]
Pollock, C. B., Shirasawa, S., Sasazuki, T., Kolch, W., Dhillon, A. S. (2005) 'Oncogenic K-RAS is required to maintain changes in cytoskeletal organization, adhesion, and motility in colon cancer cells'. Cancer Res, 65 (4):1244-50. [Details]
O'Neill, E. E., Matallanas, D., Kolch, W. (2005) 'Mammalian sterile 20-like kinases in tumor suppression: an emerging pathway'. Cancer Res, 65 (13):5485-7. [Details]
Kolch, W., Neususs, C., Pelzing, M., Mischak, H. (2005) 'Capillary electrophoresis-mass spectrometry as a powerful tool in clinical diagnosis and biomarker discovery'. Mass Spectrom Rev, 24 (6):959-77. [Details]
Kolch, W., Mischak, H., Pitt, A. R. (2005) 'The molecular make-up of a tumour: proteomics in cancer research'. Clin Sci (Lond), 108 (5):369-83. [Details]
Hagan, S., Al-Mulla, F., Mallon, E., Oien, K., Ferrier, R., Gusterson, B., Garcia, J. J., Kolch, W. (2005) 'Reduction of Raf-1 kinase inhibitor protein expression correlates with breast cancer metastasis'. Clin Cancer Res, 11 (20):7392-7. [Details]
Baral, C., Kolch, W., Shankland, C., Tran, N. (2005) 'Reasoning about the ERK signal transduction pathway using BioSigNet-RR'. Proceedings of Computational Methods in Systems Biology, CMSB 2005 :79-90. [Details]
Hagan, S., Garcia, R., Dhillon, A., Kolch, W. (2006) 'Raf kinase inhibitor protein regulation of raf and MAPK signaling'. Methods Enzymol, 407 :248-59. [Details]
Murray, E., McKenna, E. O., Burch, L. R., Dillon, J., Langridge-Smith, P., Kolch, W., Pitt, A., Hupp, T. R. (2007) 'Microarray-formatted clinical biomarker assay development using peptide aptamers to anterior gradient-2'. Biochemistry, 46 (48):13742-51. [Details]
Mischak, H., Apweiler, R., Banks, R. E., Conaway, M., Coon, J., Dominiczak, A., Ehrich, J. H., Fliser, D., Girolami, M., Hermjakob, H., Hochstrasser, D., Jankowski, J., Julian, B. A., Kolch, W., Massy, Z. A., Neusuess, C., Novak, J., Peter, K., Rossing, K., Schanstra, J., Semmes, O. J., Theodorescu, D., Thongboonkerd, V., Weissinger, E. M., Van Eyk, J. E., Yamamoto, T. (2007) 'Clinical proteomics: A need to define the field and to begin to set adequate standards'. Proteomics Clin Appl, 1 (2):148-56. [Details]
Millington, M., Grindlay, G. J., Altenbach, K., Neely, R. K., Kolch, W., Bencina, M., Read, N. D., Jones, A. C., Dryden, D. T., Magennis, S. W. (2007) 'High-precision FLIM-FRET in fixed and living cells reveals heterogeneity in a simple CFP-YFP fusion protein'. Biophys Chem, 127 (3):155-64. [Details]
Kim, D., Rath, O., Kolch, W., Cho, K. H. (2007) 'A hidden oncogenic positive feedback loop caused by crosstalk between Wnt and ERK pathways'. Oncogene, 26 (31):4571-9. [Details]
Hindley, A., Kolch, W. (2007) 'Raf-1 and B-Raf promote protein kinase C theta interaction with BAD'. Cell Signal, 19 (3):547-55. [Details]
Dhillon, A. S., von Kriegsheim, A., Grindlay, J., Kolch, W. (2007) 'Phosphatase and feedback regulation of Raf-1 signaling'. Cell Cycle, 6 (1):3-7. [Details]
Zimmerli, L. U., Schiffer, E., Zurbig, P., Good, D. M., Kellmann, M., Mouls, L., Pitt, A. R., Coon, J. J., Schmieder, R. E., Peter, K. H., Mischak, H., Kolch, W., Delles, C., Dominiczak, A. F. (2008) 'Urinary proteomic biomarkers in coronary artery disease'. Mol Cell Proteomics, 7 (2):290-8. [Details]
Xu, T. R., Baillie, G. S., Bhari, N., Houslay, T. M., Pitt, A. M., Adams, D. R., Kolch, W., Houslay, M. D., Milligan, G. (2008) 'Mutations of beta-arrestin 2 that limit self-association also interfere with interactions with the beta2-adrenoceptor and the ERK1/2 MAPKs: implications for beta2-adrenoceptor signalling via the ERK1/2 MAPKs'. Biochem J, 413 (1):51-60. [Details]
von Kriegsheim, A., Preisinger, C., Kolch, W. (2008) 'Mapping of signaling pathways by functional interaction proteomics'. Methods Mol Biol, 484 :177-92. [Details]
Vera, J., Millat, T., Kolch, W., Wolkenhauer, O. (2008) 'Dynamics of receptor and protein transducer homodimerisation'. BMC Syst Biol, 2 :92. [Details]
Sedgwick, H., Caron, F., Monaghan, P. B., Kolch, W., Cooper, J. M. (2008) 'Lab-on-a-chip technologies for proteomic analysis from isolated cells'. J R Soc Interface, 5 Suppl 2 :30. [Details]
Preisinger, C., von Kriegsheim, A., Matallanas, D., Kolch, W. (2008) 'Proteomics and phosphoproteomics for the mapping of cellular signalling networks'. Proteomics, 8 (21):4402-15. [Details]
Orton, R. J., Sturm, O. E., Gormand, A., Kolch, W., Gilbert, D. R. (2008) 'Computational modelling reveals feedback redundancy within the EGFR/ERK signalling pathway'. IET Systems Biology, 2 :173-183. [Details]
Kholodenko, B. N., Kolch, W. (2008) 'Giving space to cell signaling'. Cell, 133 (4):566-7. [Details]
Coon, J. J., Zurbig, P., Dakna, M., Dominiczak, A. F., Decramer, S., Fliser, D., Frommberger, M., Golovko, I., Good, D. M., Herget-Rosenthal, S., Jankowski, J., Julian, B. A., Kellmann, M., Kolch, W., Massy, Z., Novak, J., Rossing, K., Schanstra, J. P., Schiffer, E., Theodorescu, D., Vanholder, R., Weissinger, E. M., Mischak, H., Schmitt-Kopplin, P. (2008) 'CE-MS analysis of the human urinary proteome for biomarker discovery and disease diagnostics'. Proteomics Clin Appl, 2 (7-8):964. [Details]
Wlodkowic, D., Skommer, J., McGuinness, D., Faley, S., Kolch, W., Darzynkiewicz, Z., Cooper, J. M. (2009) 'Chip-based dynamic real-time quantification of drug-induced cytotoxicity in human tumor cells'. Anal Chem, 81 (16):6952-9. [Details]
Schilling, M., Maiwald, T., Hengl, S., Winter, D., Kreutz, C., Kolch, W., Lehmann, W. D., Timmer, J., Klingmuller, U. (2009) 'Theoretical and experimental analysis links isoform-specific ERK signalling to cell fate decisions'. Mol Syst Biol, 5 :334. [Details]
Densham, R. M., O'Neill, E., Munro, J., Konig, I., Anderson, K., Kolch, W., Olson, M. F. (2009) 'MST kinases monitor actin cytoskeletal integrity and signal via c-Jun N-terminal kinase stress-activated kinase to regulate p21Waf1/Cip1 stability'. Mol Cell Biol, 29 (24):6380-90. [Details]
Dallol, A., Kolch, W., Latif, F. (2009) 'When RASSF1A RAN into tumor suppression: Ran GTPase is a RASSF1A effector involved in controlling microtubule organization'. Cell Cycle, 8 (23):3796-7. [Details]
Cooper, W. N., Hesson, L. B., Matallanas, D., Dallol, A., von Kriegsheim, A., Ward, R., Kolch, W., Latif, F. (2009) 'RASSF2 associates with and stabilizes the proapoptotic kinase MST2'. Oncogene, 28 (33):2988-98. [Details]
Aebersold, R., Auffray, C., Baney, E., Barillot, E., Brazma, A., Brett, C., Brunak, S., Butte, A., Califano, A., Celis, J., Cufer, T., Ferrell, J., Galas, D., Gallahan, D., Gatenby, R., Goldbeter, A., Hace, N., Henney, A., Hood, L., Iyengar, R., Jackson, V., Kallioniemi, O., Klingmuller, U., Kolar, P., Kolch, W., Kyriakopoulou, C., Laplace, F., Lehrach, H., Marcus, F., Matrisian, L., Nolan, G., Pelkmans, L., Potti, A., Sander, C., Seljak, M., Singer, D., Sorger, P., Stunnenberg, H., Superti-Furga, G., Uhlen, M., Vidal, M., Weinstein, J., Wigle, D., Williams, M., Wolkenhauer, O., Zhivotovsky, B., Zinovyev, A., Zupan, B. (2009) 'Report on EU-USA workshop: how systems biology can advance cancer research (27 October 2008)'. Mol Oncol, 3 (1):9-17. [Details]
Xu, T. R., Vyshemirsky, V., Gormand, A., von Kriegsheim, A., Girolami, M., Baillie, G. S., Ketley, D., Dunlop, A. J., Milligan, G., Houslay, M. D., Kolch, W. (2010) 'Inferring signaling pathway topologies from multiple perturbation measurements of specific biochemical species'. Sci Signal, 3 (134). [Details]
Shin, S. Y., Rath, O., Zebisch, A., Choo, S. M., Kolch, W., Cho, K. H. (2010) 'Functional roles of multiple feedback loops in extracellular signal-regulated kinase and Wnt signaling pathways that regulate epithelial-mesenchymal transition'. Cancer Res, 70 (17):6715-24. [Details]
Sandison, M. E., Cumming, S. A., Kolch, W., Pitt, A. R. (2010) 'On-chip immunoprecipitation for protein purification'. Lab Chip, 10 (20):2805-13. [Details]
Kholodenko, B. N., Hancock, J. F., Kolch, W. (2010) 'Signalling ballet in space and time'. Nat Rev Mol Cell Biol, 11 (6):414-26. [Details]
Good, D. M., Zurbig, P., Argiles, A., Bauer, H. W., Behrens, G., Coon, J. J., Dakna, M., Decramer, S., Delles, C., Dominiczak, A. F., Ehrich, J. H., Eitner, F., Fliser, D., Frommberger, M., Ganser, A., Girolami, M. A., Golovko, I., Gwinner, W., Haubitz, M., Herget-Rosenthal, S., Jankowski, J., Jahn, H., Jerums, G., Julian, B. A., Kellmann, M., Kliem, V., Kolch, W., Krolewski, A. S., Luppi, M., Massy, Z., Melter, M., Neususs, C., Novak, J., Peter, K., Rossing, K., Rupprecht, H., Schanstra, J. P., Schiffer, E., Stolzenburg, J. U., Tarnow, L., Theodorescu, D., Thongboonkerd, V., Vanholder, R., Weissinger, E. M., Mischak, H., Schmitt-Kopplin, P. (2010) 'Naturally occurring human urinary peptides for use in diagnosis of chronic kidney disease'. Mol Cell Proteomics, 9 (11):2424-37. [Details]
Aksamitiene, E., Kholodenko, B. N., Kolch, W., Hoek, J. B., Kiyatkin, A. (2010) 'PI3K/Akt-sensitive MEK-independent compensatory circuit of ERK activation in ER-positive PI3K-mutant T47D breast cancer cells'. Cell Signal, 22 (9):1369-78. [Details]
Rauch, J., Moran-Jones, K., Albrecht, V., Schwarzl, T., Hunter, K., Gires, O., Kolch, W. (2011) 'c-Myc regulates RNA splicing of the A-Raf kinase and its activation of the ERK pathway'. Cancer Res, 71 (13):4664-74. [Details]
Nguyen, L. K., Munoz-Garcia, J., Maccario, H., Ciechanover, A., Kolch, W., Kholodenko, B. N. (2011) 'Switches, excitable responses and oscillations in the Ring1B/Bmi1 ubiquitination system'. PLoS Comput Biol, 7 (12). [Details]
Matallanas, D., Romano, D., Al-Mulla, F., O'Neill, E., Al-Ali, W., Crespo, P., Doyle, B., Nixon, C., Sansom, O., Drosten, M., Barbacid, M., Kolch, W. (2011) 'Mutant K-Ras activation of the proapoptotic MST2 pathway is antagonized by wild-type K-Ras'. Mol Cell, 44 (6):893-906. [Details]
Birtwistle, M. R., von Kriegsheim, A., Kida, K., Schwarz, J. P., Anderson, K. I., Kolch, W. (2011) 'Linear approaches to intramolecular Forster resonance energy transfer probe measurements for quantitative modeling'. PLoS One, 6 (11). [Details]
Birtwistle, M. R., Kolch, W. (2011) 'Biology using engineering tools: the negative feedback amplifier'. Cell Cycle, 10 (13):2069-76. [Details]
Al-Mulla, F., Bitar, M. S., Taqi, Z., Rath, O., Kolch, W. (2011) 'RAF kinase inhibitory protein (RKIP) modulates cell cycle kinetics and motility'. Mol Biosyst, 7 (3):928-41. [Details]
Aksamitiene, E., Achanta, S., Kolch, W., Kholodenko, B. N., Hoek, J. B., Kiyatkin, A. (2011) 'Prolactin-stimulated activation of ERK1/2 mitogen-activated protein kinases is controlled by PI3-kinase/Rac/PAK signaling pathway in breast cancer cells'. Cell Signal, 23 (11):1794-805. [Details]
Xu, T. R., Lu, R. F., Romano, D., Pitt, A., Houslay, M. D., Milligan, G., Kolch, W. (2012) 'Eukaryotic translation initiation factor 3, subunit a, regulates the extracellular signal-regulated kinase pathway'. Mol Cell Biol, 32 (1):88-95. [Details]
Tsyganov, M. A., Kolch, W., Kholodenko, B. N. (2012) 'The topology design principles that determine the spatiotemporal dynamics of G-protein cascades'. Mol Biosyst, 8 (3):730-43. [Details]
Santra, T., Kholodenko, B., Kolch, W. (2012) 'An integrated Bayesian framework for identifying phosphorylation networks in stimulated cells'. Adv Exp Med Biol, 736 :59-80. [Details]
Rauch, J., Kolch, W., Mahmoudi, M. (2012) 'Cell type-specific activation of AKT and ERK signaling pathways by small negatively-charged magnetic nanoparticles'. Sci Rep, 2 :868. [Details]
Pakay, J. L., Diesch, J., Gilan, O., Yip, Y. Y., Sayan, E., Kolch, W., Mariadason, J. M., Hannan, R. D., Tulchinsky, E., Dhillon, A. S. (2012) 'A 19S proteasomal subunit cooperates with an ERK MAPK-regulated degron to regulate accumulation of Fra-1 in tumour cells'. Oncogene, 31 (14):1817-24. [Details]
Birtwistle, M. R., von Kriegsheim, A., Dobrzynski, M., Kholodenko, B. N., Kolch, W. (2012) 'Mammalian protein expression noise: scaling principles and the implications for knockdown experiments'. Mol Biosyst, 8 (11):3068-76. [Details]
Birtwistle, M. R., Rauch, J., Kiyatkin, A., Aksamitiene, E., Dobrzynski, M., Hoek, J. B., Kolch, W., Ogunnaike, B. A., Kholodenko, B. N. (2012) 'Emergence of bimodal cell population responses from the interplay between analog single-cell signaling and protein expression noise'. BMC Syst Biol, 6 :109. [Details]
von Thun, A., Preisinger, C., Rath, O., Schwarz, J. P., Ward, C., Monsefi, N., Rodriguez, J., Garcia-Munoz, A., Birtwistle, M., Bienvenut, W., Anderson, K. I., Kolch, W., von Kriegsheim, A. (2013) 'Extracellular signal-regulated kinase regulates RhoA activation and tumor cell plasticity by inhibiting guanine exchange factor H1 activity'. Mol Cell Biol, 33 (22):4526-37. [Details]
Romano, D., Maccario, H., Doherty, C., Quinn, N. P., Kolch, W., Matallanas, D. (2013) 'The differential effects of wild-type and mutated K-Ras on MST2 signaling are determined by K-Ras activation kinetics'. Mol Cell Biol, 33 (9):1859-68. [Details]
Rauch, J., Kolch, W., Laurent, S., Mahmoudi, M. (2013) 'Big signals from small particles: regulation of cell signaling pathways by nanoparticles'. Chem Rev, 113 (5):3391-406. [Details]
Kolch, W., Kholodenko, B. N. (2013) 'Systems medicine: opportunities and challenges for systems biology approaches'. FEBS J, 280 (23):5937. [Details]
Doyle, B., Hagan, S., Al-Mulla, F., Scott, L., Harden, S., Paul, J., Mulcahy, H., Murray, G. I., Sheahan, K., O'Sullivan, J., Kolch, W. (2013) 'Raf kinase inhibitor protein expression combined with peritoneal involvement and lymphovascular invasion predicts prognosis in Dukes' B colorectal cancer patients'. Histopathology, 62 (3):505-10. [Details]
Brown, K. M., Day, J. P., Huston, E., Zimmermann, B., Hampel, K., Christian, F., Romano, D., Terhzaz, S., Lee, L. C., Willis, M. J., Morton, D. B., Beavo, J. A., Shimizu-Albergine, M., Davies, S. A., Kolch, W., Houslay, M. D., Baillie, G. S. (2013) 'Phosphodiesterase-8A binds to and regulates Raf-1 kinase'. Proc Natl Acad Sci U S A, 110 (16):42. [Details]
Baljuls, A., Kholodenko, B. N., Kolch, W. (2013) 'It takes two to tango--signalling by dimeric Raf kinases'. Mol Biosyst, 9 (4):551-8. [Details]
F¿¿bi¿¿n Z, Ramadurai S;Shaw G;Nasheuer HP;Kolch W;Taylor C;Barry F (2014) 'Basic fibroblast growth factor modifies the hypoxic response of human bone marrow stromal cells by ERK-mediated enhancement of HIF-1¿¿ activity'. Stem Cell Research, 12 (3):646-658. [DOI] [Details]
Romano D, Matallanas D;Frederick DT;Flaherty KT;Kolch W (2014) 'One Hippo and many masters: differential regulation of the Hippo pathway in cancer'. Biochemical Society Transactions, 42 (4):816-821. [DOI] [Details]
Turriziani B, Garcia-Munoz A;Pilkington R;Raso C;Kolch W;von Kriegsheim A (2014) 'On-beads digestion in conjunction with data-dependent mass spectrometry: a shortcut to quantitative and dynamic interaction proteomics'. Journal of Biology, 3 (2):320-332. [DOI] [Details]
Vandamme D, Minke BA;Fitzmaurice W;Kholodenko BN;Kolch W (2014) 'Systems biology-embedded target validation: improving efficacy in drug discovery'. Wiley Interdisciplinary Reviews: Systems Biology and Medicine, 6 (1):1-11. [DOI] [Details]
Lesniak, A., Kilinc, D., Rashdan, S. A., von Kriegsheim, A., Ashall, B., Zerulla, D., Kolch, W., Lee, G. U. (2014) 'In vitro study of the interaction of heregulin-functionalized magnetic-optical nanorods with MCF7 and MDA-MB-231 cells'. Faraday discussions, 175 :189-201. [Details]
Vandamme, D., Minke, B. A., Fitzmaurice, W., Kholodenko, B. N., Kolch, W. (2014) 'Systems biology-embedded target validation: improving efficacy in drug discovery'. Wiley Interdiscip Rev Syst Biol Med, 6 (1):1-11. [Details]
Vandamme, D., Herrero, A., Al-Mulla, F., Kolch, W. (2014) 'Regulation of the MAPK pathway by raf kinase inhibitory protein'. Crit Rev Oncog, 19 (6):405-15. [Details]
Turriziani, B., Garcia-Munoz, A., Pilkington, R., Raso, C., Kolch, W., von Kriegsheim, A. (2014) 'On-beads digestion in conjunction with data-dependent mass spectrometry: a shortcut to quantitative and dynamic interaction proteomics'. Biology (Basel), 3 (2):320-32. [Details]
Song, J. H., Huels, D. J., Ridgway, R. A., Sansom, O. J., Kholodenko, B. N., Kolch, W., Cho, K. H. (2014) 'The APC Network Regulates the Removal of Mutated Cells from Colonic Crypts'. Cell Rep, . [Details]
Shilo, A., Ben Hur, V., Denichenko, P., Stein, I., Pikarsky, E., Rauch, J., Kolch, W., Zender, L., Karni, R. (2014) 'Splicing factor hnRNP A2 activates the Ras-MAPK-ERK pathway by controlling A-Raf splicing in hepatocellular carcinoma development'. RNA, 20 (4):505-15. [Details]
Santra, T., Kolch, W., Kholodenko, B. N. (2014) 'Navigating the multilayered organization of eukaryotic signaling: a new trend in data integration'. PLoS Comput Biol, 10 (2). [Details]
Romano, D., Nguyen, L. K., Matallanas, D., Halasz, M., Doherty, C., Kholodenko, B. N., Kolch, W. (2014) 'Protein interaction switches coordinate Raf-1 and MST2/Hippo signalling'. Nat Cell Biol, 16 (7):673-84. [Details]
Romano, D., Matallanas, D., Frederick, D. T., Flaherty, K. T., Kolch, W. (2014) 'One Hippo and many masters: differential regulation of the Hippo pathway in cancer'. Biochem Soc Trans, 42 (4):816-21. [Details]
Milewska, M., Kolch, W. (2014) 'Mig-6 participates in the regulation of cell senescence and retinoblastoma protein phosphorylation'. Cell Signal, 26 (9):1870-1877. [Details]
Kim, J., Vandamme, D., Kim, J. R., Munoz, A. G., Kolch, W., Cho, K. H. (2014) 'Robustness and evolvability of the human signaling network'. PLoS Comput Biol, 10 (7). [Details]
Jiwaji, M., Sandison, M. E., Reboud, J., Stevenson, R., Daly, R., Barkess, G., Faulds, K., Kolch, W., Graham, D., Girolami, M. A., Cooper, J. M., Pitt, A. R. (2014) 'Quantification of Functionalised Gold Nanoparticle-Targeted Knockdown of Gene Expression in HeLa Cells'. PLoS One, 9 (6). [Details]
Jambrina, P. G., Bohuszewicz, O., Buchete, N. V., Kolch, W., Rosta, E. (2014) 'Molecular mechanisms of asymmetric RAF dimer activation'. Biochem Soc Trans, 42 (4):784-90. [Details]
Farrell, J., Kelly, C., Rauch, J., Kida, K., Garcia-Munoz, A., Monsefi, N., Turriziani, B., Doherty, C., Mehta, J. P., Matallanas, D., Simpson, J. C., Kolch, W., von Kriegsheim, A. (2014) 'HGF induces epithelial-to-mesenchymal transition by modulating the mammalian Hippo/MST2 and ISG15 pathways'. J Proteome Res, . [Details]
Fabian, Z., Ramadurai, S., Shaw, G., Nasheuer, H. P., Kolch, W., Taylor, C., Barry, F. (2014) 'Basic fibroblast growth factor modifies the hypoxic response of human bone marrow stromal cells by ERK-mediated enhancement of HIF-1alpha activity'. Stem Cell Res, 12 (3):646-658. [Details]
Duffy, D. J., Krstic, A., Schwarzl, T., Higgins, D. G., Kolch, W. (2014) 'GSK3 Inhibitors Regulate MYCN mRNA Levels and Reduce Neuroblastoma Cell Viability through Multiple Mechanisms, Including p53 and Wnt Signaling'. Mol Cancer Ther, 13 (2):454-67. [Details]
Dobrzynski, M., Nguyen, L. K., Birtwistle, M. R., von Kriegsheim, A., Blanco Fernandez, A., Cheong, A., Kolch, W., Kholodenko, B. N. (2014) 'Nonlinear signalling networks and cell-to-cell variability transform external signals into broadly distributed or bimodal responses'. J R Soc Interface, 11 (98). [Details]
Degasperi, A., Birtwistle, M. R., Volinsky, N., Rauch, J., Kolch, W., Kholodenko, B. N. (2014) 'Evaluating strategies to normalise biological replicates of Western blot data'. PLoS One, 9 (1). [Details]
S¿¿nchez-Sanz G, Matallanas D;Nguyen LK;Kholodenko BN;Rosta E;Kolch W;Buchete NV (2015) 'MST2-RASSF protein-protein interactions through SARAH domains'. Briefings in Bioinformatics, . [DOI] [Details]
Duffy DJ*, Krstic A*, Halasz M*, Schwarzl T*, Fey D, Iljin K, Mehta JP, Killick K, Whilde J, Turriziani B, Haapa-Paananen S, Fey V, Fischer M, Westermann F, Henrich KO, Bannert S, Higgins DG, Kolch W. *Joint first authors. (2015) 'Integrative omics reveals MYCN as a global suppressor of cellular signalling and enables network-based therapeutic target discovery in neuroblastoma'. Oncotarget, . [DOI] [Details]
Fey, D; Halasz, M; Dreidax, D; Kennedy, SP; Hastings, JF; Rauch, N; Munoz, AG; Pilkington, R; Fischer, M; Westermann, F; Kolch, W; Kholodenko, BN; Croucher, DR. (2015) 'Signaling pathway models as biomarkers: Patient-specific simulations of JNK activity predict the survival of neuroblastoma patients'. Science signaling, 8 (408). [DOI] [Details]
Kilinc, D., Schwab, J., Rampini, S., Ikpekha, O. W., Thampi, A., Blasiak, A., Li, P., Schwamborn, R., Kolch, W., Matallanas, D., Lee, G. U. (2015) 'A microfluidic dual gradient generator for conducting cell-based drug combination assays'. Integr Biol (Camb), . [Details]
Volinsky, N., McCarthy, C. J., Von Kriegsheim, A., Saban, N., Okada-Hatakeyama, M., Kolch, W., Kholodenko, B. N. (2015) 'Signalling mechanisms regulating phenotypic changes in breast cancer cells'. Biosci Rep, . [Details]
Varusai, T. M., Kolch, W., Kholodenko, B. N., Nguyen, L. K. (2015) 'Protein-protein interactions generate hidden feedback and feed-forward loops to trigger bistable switches, oscillations and biphasic dose-responses'. Mol Biosyst, . Available Online [Details]
Tortolina, L., Duffy, D. J., Maffei, M., Castagnino, N., Carmody, A. M., Kolch, W., Kholodenko, B. N., De Ambrosi, C., Barla, A., Biganzoli, E. M., Nencioni, A., Patrone, F., Ballestrero, A., Zoppoli, G., Verri, A., Parodi, S. (2015) 'Advances in dynamic modeling of colorectal cancer signaling-network regions, a path toward targeted therapies'. Oncotarget, 6 (7):5041-58. [Details]
Schwarzl, T., Higgins, D. G., Kolch, W., Duffy, D. J. (2015) 'Measuring transcription rate changes via time-course 4-thiouridine pulse-labelling improves transcriptional target identification'. J Mol Biol, . [Details]
Sanchez-Sanz, G., Matallanas, D., Nguyen, L. K., Kholodenko, B. N., Rosta, E., Kolch, W., Buchete, N. V. (2015) 'MST2-RASSF protein-protein interactions through SARAH domains'. Brief Bioinform, . Available Online [Details]
Ryan, C. M., Brown, J. A., Bourke, E., Prendergast, A. M., Kavanagh, C., Liu, Z., Owens, P., Shaw, G., Kolch, W., O'Brien, T., Barry, F. P. (2015) 'ROCK activity and the Gbetagamma complex mediate chemotactic migration of mouse bone marrow-derived stromal cells'. Stem Cell Res Ther, 6 (1):136. Available Online [Details]
Nguyen, L. K., Matallanas, D. G., Romano, D., Kholodenko, B. N., Kolch, W. (2015) 'Competing to coordinate cell fate decisions: the MST2-Raf-1 signaling device'. Cell Cycle, 14 (2):189-99. [Details]
Milewska, M., Romano, D., Herrero, A., Guerriero, M. L., Birtwistle, M., Quehenberger, F., Hatzl, S., Kholodenko, B. N., Segatto, O., Kolch, W., Zebisch, A. (2015) 'Mitogen-Inducible Gene-6 Mediates Feedback Inhibition from Mutated BRAF towards the Epidermal Growth Factor Receptor and Thereby Limits Malignant Transformation'. PLoS One, 10 (6). [Details]
Kolch, W., Halasz, M., Granovskaya, M., Kholodenko, B. N. (2015) 'The dynamic control of signal transduction networks in cancer cells'. Nat Rev Cancer, 15 (9):515-27. Available Online [Details]
Kim, T. H., Monsefi, N., Song, J. H., von Kriegsheim, A., Vandamme, D., Pertz, O., Kholodenko, B. N., Kolch, W., Cho, K. H. (2015) 'Network-based identification of feedback modules that control RhoA activity and cell migration'. J Mol Cell Biol, . [Details]
Kilinc, D., Lesniak, A., Rashdan, S. A., Gandhi, D., Blasiak, A., Fannin, P. C., von Kriegsheim, A., Kolch, W., Lee, G. U. (2015) 'Mechanochemical stimulation of MCF7 cells with rod-shaped Fe-Au Janus particles induces cell death through paradoxical hyperactivation of ERK'. Adv Healthc Mater, 4 (3):395-404. [Details]
Fey, D., Halasz, M., Dreidax, D., Kennedy, S. P., Hastings, J. F., Rauch, N., Munoz, A. G., Pilkington, R., Fischer, M., Westermann, F., Kolch, W., Kholodenko, B. N., Croucher, D. R. (2015) 'Signaling pathway models as biomarkers: Patient-specific simulations of JNK activity predict the survival of neuroblastoma patients'. Sci Signal, 8 (408). [Details]
Duffy, D. J., Krstic, A., Halasz, M., Schwarzl, T., Fey, D., Iljin, K., Mehta, J. P., Killick, K., Whilde, J., Turriziani, B., Haapa-Paananen, S., Fey, V., Fischer, M., Westermann, F., Henrich, K. O., Bannert, S., Higgins, D. G., Kolch, W. (2015) 'Integrative omics reveals MYCN as a global suppressor of cellular signalling and enables network-based therapeutic target discovery in neuroblastoma'. Oncotarget, 6 (41):43182-201. [Details]
Bastiaens, P., Birtwistle, M. R., Bluthgen, N., Bruggeman, F. J., Cho, K. H., Cosentino, C., de la Fuente, A., Hoek, J. B., Kiyatkin, A., Klamt, S., Kolch, W., Legewie, S., Mendes, P., Naka, T., Santra, T., Sontag, E., Westerhoff, H. V., Kholodenko, B. N. (2015) 'Silence on the relevant literature and errors in implementation'. Nat Biotechnol, 33 (4):336-9. [Details]
Kilinc D, Schwab J;Rampini S;Ikpekha OW;Thampi A;Blasiak A;Li P;Schwamborn R;Kolch W;Matallanas D;Lee GU (2016) 'A microfluidic dual gradient generator for conducting cell-based drug combination assays'. Integrative biology : quantitative biosciences from nano to macro, 8 (1):39-49. [DOI] [Details]
Jambrina, PG; Rauch, N; Pilkington, R; Rybakova, K; Nguyen, LK; Kholodenko, BN; Buchete, NV; Kolch, W; Rosta, E (2016) 'Phosphorylation of RAF Kinase Dimers Drives Conformational Changes that Facilitate Transactivation'. Angewandte Chemie International Edition, 55 (3):983-986. Available Online [DOI] [Details]
Sanchez-Sanz, G; Tywoniuk, B; Matallanas, D; Romano, D; Nguyen, LK; Kholodenko, BN; Rosta, E; Kolch, W; Buchete, NV (2016) 'SARAH Domain-mediated MST2-RASSF Dimeric Interactions'. PLoS Computational Biology, 12 (10):e1005051. Available Online [DOI] [Details]
Cahill EF, Sax T, Hartmann I, Haffner S, Holler E, Holler B, Huss R, Günther C, Parolini O, Kolch W, Eissner G (2016) 'Mesenchymal stromal cells protect endothelial cells from cytotoxic T lymphocyte induced lysis'. Scandinavian Journal of Immunology, 84 :158-164. [DOI] [Details]
Duffy, DJ; Krstic, A; Schwarzl, T; Halasz, M; Iljin, K; Fey, D; Haley, B; Whilde, J; Haapa-Paananen, S; Fey, V; Fischer, M; Westermann, F; Henrich, KO; Bannert, S; Higgins, DG; Kolch, W. (2016) 'Wnt signalling is a bi-directional vulnerability of cancer cells'. Oncotarget, . Available Online [DOI] [Details]
Halasz, M; Kholodenko BN; Kolch W; Santra T (2016) 'Integrating network reconstruction with mechanistic modeling to predict cancer therapies'. Science signaling, 9 (455):ra114. [DOI] [Details]
Halasz M; Kholodenko BN; Kolch W; Santra T (2016) 'Integrating network reconstruction with mechanistic modeling to predict cancer therapies'. Science signaling, 9 (455):ra114. [DOI] [Details]
Rauch, N; Rukhlenko, OS; Kolch, W; Kholodenko, BN (2016) 'MAPK kinase signalling dynamics regulate cell fate decisions and drug resistance'. Current Opinion in Structural Biology, 41 :151-158. Available Online [DOI] [Details]
Rauch, N; Rukhlenko, OS; Kolch, W; Kholodenko, BN (2016) 'MAPK kinase signalling dynamics regulate cell fate decisions and drug resistance'. Current Opinion in Structural Biology, 41 :151-158. Available Online [DOI] [Details]
Stanley, E., Delatola, E. I., Nkuipou-Kenfack, E., Spooner, W., Kolch, W., Schanstra, J. P., Mischak, H., Koeck, T. (2016) 'Comparison of different statistical approaches for urinary peptide biomarker detection in the context of coronary artery disease'. BMC Bioinformatics, 17 (1):496. [Details]
Sanchez-Sanz, G., Tywoniuk, B., Matallanas, D., Romano, D., Nguyen, L. K., Kholodenko, B. N., Rosta, E., Kolch, W., Buchete, N. V. (2016) 'SARAH Domain-Mediated MST2-RASSF Dimeric Interactions'. PLoS Comput Biol, 12 (10). [Details]
Sanchez-Sanz, G., Matallanas, D., Nguyen, L. K., Kholodenko, B. N., Rosta, E., Kolch, W., Buchete, N. V. (2016) 'MST2-RASSF protein-protein interactions through SARAH domains'. Brief Bioinform, 17 (4):593-602. [Details]
Rauch, N., Rukhlenko, O. S., Kolch, W., Kholodenko, B. N. (2016) 'MAPK kinase signalling dynamics regulate cell fate decisions and drug resistance'. Curr Opin Struct Biol, 41 :151-158. [Details]
Rauch, J., Vandamme, D., Mack, B., McCann, B., Volinsky, N., Blanco, A., Gires, O., Kolch, W. (2016) 'Differential localization of A-Raf regulates MST2-mediated apoptosis during epithelial differentiation'. Cell Death Differ, 23 (8):1283-1295. [Details]
Kilinc, D., Schwab, J., Rampini, S., Ikpekha, O. W., Thampi, A., Blasiak, A., Li, P., Schwamborn, R., Kolch, W., Matallanas, D., Lee, G. U. (2016) 'A microfluidic dual gradient generator for conducting cell-based drug combination assays'. Integr Biol (Camb), 8 (1):39-49. [Details]
Jambrina, P. G., Rauch, N., Pilkington, R., Rybakova, K., Nguyen, L. K., Kholodenko, B. N., Buchete, N. V., Kolch, W., Rosta, E. (2016) 'Phosphorylation of RAF Kinase Dimers Drives Conformational Changes that Facilitate Transactivation'. Angew Chem Int Ed Engl, 55 (3):983-6. [Details]
Iglesias-Martinez, L. F., Kolch, W., Santra, T. (2016) 'BGRMI: A method for inferring gene regulatory networks from time-course gene expression data and its application in breast cancer research'. Sci Rep, 6 :37140. [Details]
Herrero, A., Matallanas, D., Kolch, W. (2016) 'The spatiotemporal regulation of RAS signalling'. Biochem Soc Trans, 44 (5):1517-1522. [Details]
Halasz, M., Kholodenko, B. N., Kolch, W., Santra, T. (2016) 'Integrating network reconstruction with mechanistic modeling to predict cancer therapies'. Sci Signal, 9 (455). [Details]
Evans, I. M., Kennedy, S. A., Paliashvili, K., Santra, T., Yamaji, M., Lovering, R. C., Britton, G., Frankel, P., Kolch, W., Zachary, I. C. (2016) 'VEGF promotes assembly of the p130Cas interactome to drive endothelial chemotactic signalling and angiogenesis'. Mol Cell Proteomics, . [Details]
Duffy, D. J., Krstic, A., Schwarzl, T., Halasz, M., Iljin, K., Fey, D., Haley, B., Whilde, J., Haapa-Paananen, S., Fey, V., Fischer, M., Westermann, F., Henrich, K. O., Bannert, S., Higgins, D. G., Kolch, W. (2016) 'Wnt signalling is a bi-directional vulnerability of cancer cells'. Oncotarget, . [Details]
Dernayka, L., Rauch, N., Jarboui, M. A., Zebisch, A., Texier, Y., Horn, N., Romano, D., Gloeckner, C. J., Kriegsheim, Av, Ueffing, M., Kolch, W., Boldt, K. (2016) 'Autophosphorylation on S614 inhibits the activity and the transforming potential of BRAF'. Cell Signal, 28 (9):1432-9. [Details]
Cahill, E. F., Sax, T., Hartmann, I., Haffner, S., Holler, E., Holler, B., Huss, R., Gunther, C., Parolini, O., Kolch, W., Eissner, G. (2016) 'Mesenchymal Stromal Cells Protect Endothelial Cells from Cytotoxic T Lymphocyte-Induced Lysis'. Scand J Immunol, 84 (3):158-64. [Details]
Byrne, K. M., Monsefi, N., Dawson, J. C., Degasperi, A., Bukowski-Wills, J. C., Volinsky, N., Dobrzynski, M., Birtwistle, M. R., Tsyganov, M. A., Kiyatkin, A., Kida, K., Finch, A. J., Carragher, N. O., Kolch, W., Nguyen, L. K., von Kriegsheim, A., Kholodenko, B. N. (2016) 'Bistability in the Rac1, PAK, and RhoA Signaling Network Drives Actin Cytoskeleton Dynamics and Cell Motility Switches'. Cell Syst, 2 (1):38-48. [Details]
Baljuls, A., Dobrzynski, M., Rauch, J., Rauch, N., Kolch, W. (2016) 'Stabilization of C-RAF:KSR1 complex by DiRas3 reduces availability of C-RAF for dimerization with B-RAF'. Cell Signal, 28 (10):1451-62. [Details]
Daly C., Shine L., Heffernan T., Deeti S., Reynolds A., O¿Connor J.J., Dillon E., Duffy D., Kolch W., Cagney G., Kennedy B.N. (2017) 'A brain-derived neurotrophic factor mimetic is sufficient to restore cone photoreceptor visual function in an inherited blindness model'. Scientific Reports, 7 :11230. [DOI] [Details]
Santra, T., Roche, S., Conlon, N., O'Donovan, N., Crown, J., O'Connor, R., Kolch, W. (2017) 'Identification of potential new treatment response markers and therapeutic targets using a Gaussian process-based method in lapatinib insensitive breast cancer models'. PLoS One, 12 (5). [Details]
Rauch, J., Kolch, W. (2017) 'Spatial regulation of ARAF controls the MST2-Hippo pathway'. Small GTPases, :1-6. [Details]
Radic-Sarikas, B., Halasz, M., Huber, K. V. M., Winter, G. E., Tsafou, K. P., Papamarkou, T., Brunak, S., Kolch, W., Superti-Furga, G. (2017) 'Lapatinib potentiates cytotoxicity of YM155 in neuroblastoma via inhibition of the ABCB1 efflux transporter'. Sci Rep, 7 (1):3091. [Details]
Minke, B., Vandamme, D., Schwarzl, T., Kolch, W., Martin, F. (2017) 'Next Generation RNA Sequencing Analysis Reveals Expression of a Transient EMT Profile During Early Organization of MCF10A Cells in 3D'. Methods Mol Biol, 1501 :233-243. [Details]
Latosinska, A., Mokou, M., Makridakis, M., Mullen, W., Zoidakis, J., Lygirou, V., Frantzi, M., Katafigiotis, I., Stravodimos, K., Hupe, M. C., Dobrzynski, M., Kolch, W., Merseburger, A. S., Mischak, H., Roubelakis, M. G., Vlahou, A. (2017) 'Proteomics analysis of bladder cancer invasion: Targeting EIF3D for therapeutic intervention'. Oncotarget, . [Details]
Fasterius, E., Raso, C., Kennedy, S., Rauch, N., Lundin, P., Kolch, W., Uhlen, M., Al-Khalili Szigyarto, C. (2017) 'A novel RNA sequencing data analysis method for cell line authentication'. PLoS One, 12 (2). [Details]
Evans, I. M., Kennedy, S. A., Paliashvili, K., Santra, T., Yamaji, M., Lovering, R. C., Britton, G., Frankel, P., Kolch, W., Zachary, I. C. (2017) 'Vascular Endothelial Growth Factor (VEGF) Promotes Assembly of the p130Cas Interactome to Drive Endothelial Chemotactic Signaling and Angiogenesis'. Mol Cell Proteomics, 16 (2):168-180. [Details]
Duffy, D. J., Krstic, A., Halasz, M., Schwarzl, T., Konietzny, A., Iljin, K., Higgins, D. G., Kolch, W. (2017) 'Retinoic acid and TGF-beta signalling cooperate to overcome MYCN-induced retinoid resistance'. Genome Med, 9 (1):15. [Details]
Duffy, DJ; Krstic, A; Halasz, M; Schwarzl, T; Konietzny, A; Iljin, K; Higgins, DG; Kolch, W. (2017) 'Retinoic acid and TGF-β signalling cooperate to overcome MYCN-induced retinoid resistance'. Genome Medicine, 9 (1):15. Available Online [DOI] [Details]
Byrne KM, Monsefi N;Dawson JC;Degasperi A;Bukowski-Wills JC;Volinsky N;Dobrzy¿¿ski M;Birtwistle MR;Tsyganov MA;Kiyatkin A;Kida K;Finch AJ;Carragher NO;Kolch W;Nguyen LK;von Kriegsheim A;Kholodenko BN (2016) 'Bistability in the Rac1, PAK, and RhoA Signaling Network Drives Actin Cytoskeleton Dynamics and Cell Motility Switches'. Cell systems, 2 (1):38-48. [DOI] [Details]
Rauch J, Vandamme D;Mack B;McCann B;Volinsky N;Blanco A;Gires O;Kolch W (2016) 'Differential localization of A-Raf regulates MST2-mediated apoptosis during epithelial differentiation'. Cell Death and Differentiation, . [DOI] [Details]
Vandamme D, Herrero A;Al-Mulla F;Kolch W (2015) 'Regulation of the MAPK pathway by raf kinase inhibitory protein'. Critical reviews in oncogenesis, 19 (6):405-415. [DOI] [Details]
Jambrina PG, Rauch N;Pilkington R;Rybakova K;Nguyen LK;Kholodenko BN;Buchete NV;Kolch W;Rosta E (2015) 'Phosphorylation of RAF Kinase Dimers Drives Conformational Changes that Facilitate Transactivation'. Angewandte Chemie International Edition, . [DOI] [Details]
Duffy DJ, Krstic A;Halasz M;Schwarzl T;Fey D;Iljin K;Mehta JP;Killick K;Whilde J;Turriziani B;Haapa-Paananen S;Fey V;Fischer M;Westermann F;Henrich KO;Bannert S;Higgins DG;Kolch W (2015) 'Integrative omics reveals MYCN as a global suppressor of cellular signalling and enables network-based therapeutic target discovery in neuroblastoma'. Oncotarget, 6 (41):43182-43201. [DOI] [Details]
Fey D, Halasz M;Dreidax D;Kennedy SP;Hastings JF;Rauch N;Munoz AG;Pilkington R;Fischer M;Westermann F;Kolch W;Kholodenko BN;Croucher DR (2015) 'Signaling pathway models as biomarkers: Patient-specific simulations of JNK activity predict the survival of neuroblastoma patients'. Science signaling, 8 (408). [DOI] [Details]
Milewska M, Romano D;Herrero A;Guerriero ML;Birtwistle M;Quehenberger F;Hatzl S;Kholodenko BN;Segatto O;Kolch W;Zebisch A (2015) 'Mitogen-Inducible Gene-6 Mediates Feedback Inhibition from Mutated BRAF towards the Epidermal Growth Factor Receptor and Thereby Limits Malignant Transformation'. PLoS ONE, 10 (6). [DOI] [Details]
Nguyen LK, Matallanas DG;Romano D;Kholodenko BN;Kolch W (2015) 'Competing to coordinate cell fate decisions: the MST2-Raf-1 signaling device'. Cell Cycle, 14 (2):189-199. [DOI] [Details]
Kilinc D, Lesniak A;Rashdan SA;Gandhi D;Blasiak A;Fannin PC;von Kriegsheim A;Kolch W;Lee GU (2015) 'Mechanochemical stimulation of MCF7 cells with rod-shaped Fe-Au Janus particles induces cell death through paradoxical hyperactivation of ERK'. Advanced healthcare materials, 4 (3):395-404. [DOI] [Details]
Tortolina L, Duffy DJ;Maffei M;Castagnino N;Carmody AM;Kolch W;Kholodenko BN;De Ambrosi C;Barla A;Biganzoli EM;Nencioni A;Patrone F;Ballestrero A;Zoppoli G;Verri A;Parodi S (2015) 'Advances in dynamic modeling of colorectal cancer signaling-network regions, a path toward targeted therapies'. Oncotarget, 6 (7):5041-5058. [Details]
Volinsky N, McCarthy CJ;von Kriegsheim A;Saban N;Okada-Hatakeyama M;Kolch W;Kholodenko BN (2015) 'Signalling mechanisms regulating phenotypic changes in breast cancer cells'. Bioscience Reports, 35 (2). [DOI] [Details]
Kim TH, Monsefi N;Song JH;von Kriegsheim A;Vandamme D;Pertz O;Kholodenko BN;Kolch W;Cho KH (2015) 'Network-based identification of feedback modules that control RhoA activity and cell migration'. Journal of molecular cell biology, 7 (3):242-252. [DOI] [Details]
Ryan CM, Brown JA;Bourke E;Prendergast ¿¿M;Kavanagh C;Liu Z;Owens P;Shaw G;Kolch W;O'Brien T;Barry FP (2015) 'ROCK activity and the G¿¿¿¿ complex mediate chemotactic migration of mouse bone marrow-derived stromal cells'. Stem Cell Research and Therapy, 6 . [DOI] [Details]
Kolch W, Halasz M;Granovskaya M;Kholodenko BN (2015) 'The dynamic control of signal transduction networks in cancer cells'. Nature Reviews Cancer, 15 (9):515-527. [DOI] [Details]
Schwarzl T, Higgins DG;Kolch W;Duffy DJ (2015) 'Measuring Transcription Rate Changes via Time-Course 4-Thiouridine Pulse-Labelling Improves Transcriptional Target Identification'. Molecular Biology, 427 (21):3368-3374. [DOI] [Details]
Varusai TM, Kolch W;Kholodenko BN;Nguyen LK (2015) 'Protein-protein interactions generate hidden feedback and feed-forward loops to trigger bistable switches, oscillations and biphasic dose-responses'. Molecular BioSystems, 11 (10):2750-2762. [DOI] [Details]
Lesniak A, Kilinc D;Rashdan SA;von Kriegsheim A;Ashall B;Zerulla D;Kolch W;Lee GU (2015) 'In vitro study of the interaction of heregulin-functionalized magnetic-optical nanorods with MCF7 and MDA-MB-231 cells'. Faraday Discussions, 175 :189-201. [DOI] [Details]
Song, J.-H. and Huels, D.J. and Ridgway, R.A. and Sansom, O.J. and Kholodenko, B.N. and Kolch, W. and Cho, K.-H. (2014) 'The APC network regulates the removal of mutated cells from colonic crypts'. Cell Reports, 7 (1):94-103. Available Online [DOI] [Details]
Vandamme, D. and Minke, B.A. and Fitzmaurice, W. and Kholodenko, B.N. and Kolch, W. (2014) 'Systems biology-embedded target validation: Improving efficacy in drug discovery'. Wiley Interdisciplinary Reviews: Systems Biology and Medicine, 6 (1):1-11. Available Online [DOI] [Details]
Milewska, M. and Kolch, W. (2014) 'Mig-6 participates in the regulation of cell senescence and retinoblastoma protein phosphorylation'. Cellular Signalling, 26 (9):1870-1877. Available Online [DOI] [Details]
Kim, J. and Vandamme, D. and Kim, J.-R. and Munoz, A.G. and Kolch, W. and Cho, K.-H. (2014) 'Robustness and Evolvability of the Human Signaling Network'. PLoS Computational Biology, 10 (7). Available Online [DOI] [Details]
Jambrina, P.G. and Bohuszewicz, O. and Buchete, N.-V. and Kolch, W. and Rosta, E. (2014) 'Molecular mechanisms of asymmetric RAF dimer activation'. Biochemical Society Transactions, 42 (4):784-790. Available Online [DOI] [Details]
Santra, T. and Kolch, W. and Kholodenko, B.N. (2014) 'Navigating the Multilayered Organization of Eukaryotic Signaling: A New Trend in Data Integration'. PLoS Computational Biology, 10 (2). Available Online [DOI] [Details]
Romano, D. and Matallanas, D. and Frederick, D.T. and Flaherty, K.T. and Kolch, W. (2014) 'One Hippo and many masters: Differential regulation of the Hippo pathway in cancer'. Biochemical Society Transactions, 42 (4):816-821. Available Online [DOI] [Details]
Romano, D; Nguyen, LK; Matallanas, D; Halasz, M; Doherty, C; Kholodenko, BN; Kolch, W. (2014) 'Protein interaction switches coordinate Raf-1 and MST2/Hippo signalling'. Nature Cell Biology, 16 (7):673-684. Available Online [DOI] [Details]
Shilo, A. and Hur, V.B. and Denichenko, P. and Stein, I. and Pikarsky, E. and Rauch, J. and Kolch, W. and Zender, L. and Karni, R. (2014) 'Splicing factor hnRNP A2 activates the Ras-MAPK-ERK pathway by controlling A-Raf splicing in hepatocellular carcinoma development'. RNA, 20 (4):505-515. Available Online [DOI] [Details]
Degasperi, A. and Birtwistle, M.R. and Volinsky, N. and Rauch, J. and Kolch, W. and Kholodenko, B.N. (2014) 'Evaluating strategies to normalise biological replicates of western blot data'. PLoS ONE, 9 (1). Available Online [DOI] [Details]
Duffy, D.J. and Krstic, A. and Schwarzl, T. and Higgins, D.G. and Kolch, W. (2014) 'GSK3 inhibitors regulate MYCN mRNA levels and reduce neuroblastoma cell viability through multiple mechanisms, including p53 and Wnt signaling'. Molecular Cancer Therapeutics, 13 (2):454-467. Available Online [DOI] [Details]
Turriziani, B. and Garcia-Munoz, A. and Pilkington, R. and Raso, C. and Kolch, W. and von Kriegsheim, A. (2014) 'On-beads digestion in conjunction with data-dependent mass spectrometry: A shortcut to quantitative and dynamic interaction proteomics'. Biology, 3 (2):320-332. Available Online [DOI] [Details]
Fábián, Z. and Ramadurai, S. and Shaw, G. and Nasheuer, H.-P. and Kolch, W. and Taylor, C. and Barry, F. (2014) 'Basic fibroblast growth factor modifies the hypoxic response of human bone marrow stromal cells by ERK-mediated enhancement of HIF-1α activity'. Stem Cell Research, 12 (3):646-658. Available Online [DOI] [Details]
Farrell, J. and Kelly, C. and Rauch, J. and Kida, K. and García-Muñoz, A. and Monsefi, N. and Turriziani, B. and Doherty, C. and Mehta, J.P. and Matallanas, D. and Simpson, J.C. and Kolch, W. and Von Kriegsheim, A. (2014) 'HGF induces epithelial-to-mesenchymal transition by modulating the mammalian Hippo/MST2 and ISG15 pathways'. Journal of Proteome Research, 13 (6):2874-2886. Available Online [DOI] [Details]
Jiwaji, M. and Sandison, M.E. and Reboud, J. and Stevenson, R. and Daly, R. and Barkess, G. and Faulds, K. and Kolch, W. and Graham, D. and Girolami, M.A. and Cooper, J.M. and Pitt, A.R. (2014) 'Quantification of functionalised gold nanoparticle-targeted knockdown of gene expression in HeLa cells'. PLoS ONE, 9 (6). Available Online [DOI] [Details]
Dobrzyſski, M. and Nguyen, L.K. and Birtwistle, M.R. and Von Kriegsheim, A. and Fernández, A.B. and Cheong, A. and Kolch, W. and Kholodenko, B.N. (2014) 'Nonlinear signalling networks and cell-to-cell variability transform external signals into broadly distributed or bimodal responses'. Journal of the Royal Society Interface, 11 (98). Available Online [DOI] [Details]
Santra, T., Kolch, W., Kholodenko, B. N. (2013) 'Integrating Bayesian variable selection with Modular Response Analysis to infer biochemical network topology'. BMC Syst Biol, 7 :57. [Details]
Baljuls A, Kholodenko BN, Kolch W (2013) 'It takes two to tango--signalling by dimeric Raf kinases'. Molecular BioSystems, 9 (4):551-558. [DOI] Link to full text [Details]
von Thun A, Preisinger C, Rath O, Schwarz JP, Ward C, Monsefi N, Rodríguez J, Garcia-Munoz A, Birtwistle M, Bienvenut W, Anderson K, Kolch W, von Kriegsheim A (2013) 'ERK regulates RhoA activation and tumour cell plasticity by inhibiting GEF-H1 activity'. Molecular Cell, . [DOI] [Details]
Brown, KM,Day, JP,Huston, E,Zimmermann, B,Hampel, K,Christian, F,Romano, D,Terhzaz, S,Lee, LCY,Willis, MJ,Morton, DB,Beavo, JA,Shimizu-Albergine, M,Davies, SA,Kolch, W,Houslay, MD,Baillie, GS (2013) 'Phosphodiesterase-8A binds to and regulates Raf-1 kinase'. Proceedings of the National Academy of Sciences of the United States of America, 110 :1533-1542. [DOI] [Details]
Romano, D,Maccario, H,Doherty, C,Quinn, NP,Kolch, W,Matallanas, D (2013) 'The Differential Effects of Wild-Type and Mutated K-Ras on MST2 Signaling Are Determined by K-Ras Activation Kinetics'. Molecular and Cellular Biology, 33 :1859-1868. [DOI] [Details]
Doyle, B,Hagan, S,Al-Mulla, F,Scott, L,Harden, S,Paul, J,Mulcahy, H,Murray, GI,Sheahan, K,O'Sullivan, J,Kolch, W (2013) 'Raf kinase inhibitor protein expression combined with peritoneal involvement and lymphovascular invasion predicts prognosis in Dukes' B colorectal cancer patients'. Histopathology, 62 :505-510. [DOI] [Details]
Vandamme, D., Fitzmaurice, W., Kholodenko, B., Kolch, W. (2013) 'Systems medicine: helping us understand the complexity of disease'. QJM, 106 (10):891-5. [Details]
Vandamme, D., Minke, B. A., Fitzmaurice, W., Kholodenko, B. N., Kolch, W. (2013) 'Systems biology-embedded target validation: improving efficacy in drug discovery'. Wiley Interdiscip Rev Syst Biol Med, . [Details]
von Thun, A., Preisinger, C., Rath, O., Schwarz, J. P., Ward, C., Monsefi, N., Rodriguez, J., Garcia-Munoz, A., Birtwistle, M., Bienvenut, W., Anderson, K. I., Kolch, W., von Kriegsheim, A. (2013) 'Extracellular Signal-Regulated Kinase Regulates RhoA Activation and Tumor Cell Plasticity by Inhibiting Guanine Exchange Factor H1 Activity'. Mol Cell Biol, 33 (22):4526-37. [Details]
Reiterer, V., Fey, D., Kolch, W., Kholodenko, B. N., Farhan, H. (2013) 'Pseudophosphatase STYX modulates cell-fate decisions and cell migration by spatiotemporal regulation of ERK1/2'. Proceedings of the National Academy of Sciences USA, 110 (31):43. [Details]
Rauch, J., Kolch, W., Laurent, S., Mahmoudi, M. (2013) 'Big Signals from Small Particles: Regulation of Cell Signaling Pathways by Nanoparticles'. Chem Rev, . [Details]
Preisinger, C., Schwarz, J. P., Bleijerveld, O. B., Corradini, E., Muller, P. J., Anderson, K. I., Kolch, W., Scholten, A., Heck, A. J. (2013) 'Imatinib-dependent tyrosine phosphorylation profiling of Bcr-Abl-positive chronic myeloid leukemia cells'. Leukemia, 27 (3):743-6. [Details]
Nikonova, E., Tsyganov, M. A., Kolch, W., Fey, D., Kholodenko, B. N. (2013) 'Control of the G-protein cascade dynamics by GDP dissociation inhibitors'. Mol Biosyst, 9 (10):2454-62. [Details]
Nguyen, L. K., Kolch, W., Kholodenko, B. N. (2013) 'When ubiquitination meets phosphorylation: a systems biology perspective of EGFR/MAPK signalling'. Cell Commun Signal, 11 :52. [Details]
Kolch, W., Kholodenko, B. (2013) 'Systems medicine: opportunities and challenges for systems biology approaches'. FEBS J, . [Details]
Zebisch, A., Wolfler, A., Fried, I., Wolf, O., Lind, K., Bodner, C., Haller, M., Drasche, A., Pirkebner, D., Matallanas, D., Rath, O., Blyth, K., Delwel, R., Taskesen, E., Quehenberger, F., Kolch, W., Troppmair, J., Sill, H. (2012) 'Frequent loss of RAF kinase inhibitor protein expression in acute myeloid leukemia'. Leukemia, 26 (8):1842-9. [DOI] [Details]
Santra T, Kholodenko B, Kolch W (2012) 'An integrated Bayesian framework for identifying phosphorylation networks in stimulated cells'. Frontiers in Modeling and Control of Breathing, 736 :59-80. [DOI] Link to full text [Details]
Tsyganov MA, Kolch W, Kholodenko BN (2012) 'The topology design principles that determine the spatiotemporal dynamics of G-protein cascades'. Molecular BioSystems, 8 (3):730-743. [DOI] Link to full text [Details]
Birtwistle MR, Rauch J, Kiyatkin A, Aksamitiene E, Dobrzynski M, Hoek JB, Kolch W, Ogunnaike BA, Kholodenko BN (2012) 'Emergence of bimodal cell population responses from the interplay between analog single-cell signaling and protein expression noise'. BMC systems biology, 6 . [DOI] Link to full text [Details]
Birtwistle MR, Kriegsheim Av, DobrzyÅski M, Kholodenko BN, Kolch W (2012) 'Mammalian protein expression noise: scaling principles and the implications for knockdown experiments'. Molecular BioSystems, 8 (11):3068-3076. [DOI] Link to full text [Details]
von Thun, A., Birtwistle, M., Kalna, G., Grindlay, J., Strachan, D., Kolch, W., von Kriegsheim, A., Norman, J. C. (2012) 'ERK2 drives tumour cell migration in three-dimensional microenvironments by suppressing expression of Rab17 and liprin-beta2'. Cell, 125 (Pt 6):1465-77. [DOI] [Details]
Rauch, J., Kolch, W., Mahmoudi, M. (2012) 'Cell Type-Specific Activation of AKT and ERK Signaling Pathways by Small Negatively-Charged Magnetic Nanoparticles'. Sci Rep, 2 :868. [Details]
Rauch, J., Kolch, W. (2012) 'A-Raf'. Encyclopedia of Signaling Molecules, Springer New York: New York, NY . [Details]
Kholodenko, B., Yaffe, M. B., Kolch, W. (2012) 'Computational approaches for analyzing information flow in biological networks'. Science signaling, 5 (220). [DOI] [Details]
Jiwaji, M., Daly, R., Gibriel, A., Barkess, G., McLean, P., Yang, J., Pansare, K., Cumming, S., McLauchlan, A., Kamola, P. J., Bhutta, M. S., West, A. G., West, K. L., Kolch, W., Girolami, M. A., Pitt, A. R. (2012) 'Unique reporter-based sensor platforms to monitor signalling in cells'. PLoS One, 7 (11). [Details]
Fey, D., Croucher, D. R., Kolch, W., Kholodenko, B. N. (2012) 'Crosstalk and signaling switches in mitogen-activated protein kinase cascades'. Front Physiology, 3 :355. Available Online [DOI] [Details]
Xu, T. R., Lu, R. F., Romano, D., Pitt, A., Houslay, M. D., Milligan, G., Kolch, W. (2011) 'The Translation Factor eIF3a Regulates the Extracellular Signal regulated Kinase (ERK) Pathway'. Mol Cell Biol, . [Details]
Aksamitiene, E,Achanta, S,Kolch, W,Kholodenko, BN,Hoek, JB,Kiyatkin, A; (2011) 'Prolactin-stimulated activation of ERK1/2 mitogen-activated protein kinases is controlled by PI3-kinase/Rac/PAK signaling pathway in breast cancer cells'. Cellular Signalling, 23 :1794-1805. [DOI] [Details]
Rauch, J,Moran-Jones, K,Albrecht, V,Schwarzl, T,Hunter, K,Gires, O,Kolch, W; (2011) 'c-Myc Regulates RNA Splicing of the A-Raf Kinase and Its Activation of the ERK Pathway'. Cancer Research, 71 :4664-4674. [DOI] [Details]
Birtwistle, MR,Kolch, W; (2011) 'Biology using engineering tools The negative feedback amplifier'. Cell, 10 :2069-2076. [DOI] Link to full text [Details]
al-Mulla, F,Bitar, MS,Taqi, Z,Rath, O,Kolch, W; (2011) 'RAF kinase inhibitory protein (RKIP) modulates cell cycle kinetics and motility'. Molecular BioSystems, 7 :928-941. [DOI] [Details]
Nguyen LK, Munoz-García J, Maccario H, Ciechanover A, Kolch W, Kholodenko BN (2011) 'Switches, excitable responses and oscillations in the Ring1B/Bmi1 ubiquitination system'. PLoS Computational Biology, 7 (12). [DOI] Link to full text [Details]
Rauch, J., Volinsky, N., Romano, D., Kolch, W. (2011) 'The secret life of kinases: functions beyond catalysis'. Cell communication and signaling : CCS, 9 (1):23. Available Online [Details]
Pakay, J. L., Diesch, J., Gilan, O., Yip, Y. Y., Sayan, E., Kolch, W., Mariadason, J. M., Hannan, R. D., Tulchinsky, E., Dhillon, A. S. (2011) 'A 19S proteasomal subunit cooperates with an ERK MAPK-regulated degron to regulate accumulation of Fra-1 in tumour cells'. Oncogene, . [Details]
Matallanas, D., Romano, D., Al-Mulla, F., O'Neill, E., Al-Ali, W., Crespo, P., Doyle, B., Nixon, C., Sansom, O., Drosten, M., Barbacid, M., Kolch, W. (2011) 'Mutant K-Ras Activation of the Proapoptotic MST2 Pathway Is Antagonized by Wild-Type K-Ras'. Mol Cell, 44 (6):893-906. [Details]
Matallanas, D., Birtwistle, M., Romano, D., Zebisch, A., Rauch, J., von Kriegsheim, A., Kolch, W. (2011) 'Raf family kinases: old dogs have learned new tricks'. Genes Cancer, 2 (3):232-60. Available Online [Details]
Birtwistle, M. R., von Kriegsheim, A., Kida, K., Schwarz, J. P., Anderson, K. I., Kolch, W. (2011) 'Linear approaches to intramolecular forster resonance energy transfer probe measurements for quantitative modeling'. PLoS One, 6 (11). [Details]
Al-Mulla, F., Bitar, M. S., Al-Maghrebi, M., Behbehani, A. I., Al-Ali, W., Rath, O., Doyle, B., Tan, K. Y., Pitt, A., Kolch, W. (2011) 'Raf kinase inhibitor protein RKIP enhances signaling by glycogen synthase kinase-3beta'. Cancer Res, 71 (4):1334-43. [Details]
Vera, J., Rath, O., Balsa-Canto, E., Banga, J. R., Kolch, W., Wolkenhauer, O. (2010) 'Investigating dynamics of inhibitory and feedback loops in ERK signalling using power-law models'. Mol Biosyst, 6 (11):2174-91. [Details]
Xu TR, Vyshemirsky V, Gormand A, von Kriegsheim A, Girolami M, Baillie GS, Ketley D, Dunlop AJ, Milligan G, Houslay MD, Kolch W; (2010) 'Inferring signaling pathway topologies from multiple perturbation measurements of specific biochemical species'. Science signaling, 3 (134). [Details]
Kholodenko BN, Hancock JF, Kolch W; (2010) 'Signalling ballet in space and time'. Nature reviews. Molecular cell biology, 11 (6):414-426. [DOI] Link to full text [Details]
Good, DM,Zurbig, P,Argiles, A,Bauer, HW,Behrens, G,Coon, JJ,Dakna, M,Decramer, S,Delles, C,Dominiczak, AF,Ehrich, JHH,Eitner, F,Fliser, D,Frommberger, M,Ganser, A,Girolami, MA,Golovko, I,Gwinner, W,Haubitz, M,Herget-Rosenthal, S,Jankowski, J,Jahn, H,Jerums, G,Julian, BA,Kellmann, M,Kliem, V,Kolch, W,Krolewski, AS,Luppi, M,Massy, Z,Melter, M,Neususs, C,Novak, J,Peter, K,Rossing, K,Rupprecht, H,Schanstra, JP,Schiffer, E,Stolzenburg, JU,Tarnow, L,Theodorescu, D,Thongboonkerd, V,Vanholder, R,Weissinger, EM,Mischak, H,Schmitt-Kopplin, P; (2010) 'Naturally Occurring Human Urinary Peptides for Use in Diagnosis of Chronic Kidney Disease'. Molecular & Cellular Proteomics, 9 :2424-2437. [DOI] [Details]
Sandison, ME,Cumming, SA,Kolch, W,Pitt, AR; (2010) 'On-chip immunoprecipitation for protein purification'. Lab on a Chip, 10 :2805-2813. [DOI] [Details]
Shin, SY,Rath, O,Zebisch, A,Choo, SM,Kolch, W,Cho, KH; (2010) 'Functional Roles of Multiple Feedback Loops in Extracellular Signal-Regulated Kinase and Wnt Signaling Pathways That Regulate Epithelial-Mesenchymal Transition'. Cancer Research, 70 :6715-6724. [DOI] [Details]
Aksamitiene, E,Kholodenko, BN,Kolch, W,Hoek, JB,Kiyatkin, A; (2010) 'PI3K/Akt-sensitive MEK-independent compensatory circuit of ERK activation in ER-positive PI3K-mutant T47D breast cancer cells'. Cellular Signalling, 22 :1369-1378. [DOI] [Details]
Sturm, O. E., Orton, R., Grindlay, J., Birtwistle, M., Vyshemirsky, V., Gilbert, D., Calder, M., Pitt, A., Kholodenko, B., Kolch, W. (2010) 'The mammalian MAPK/ERK pathway exhibits properties of a negative feedback amplifier'. Sci Signal, 3 (153). [Details]
Stocki, P., Morris, N. J., Preisinger, C., Wang, X. N., Kolch, W., Multhoff, G., Dickinson, A. M. (2010) 'Identification of potential HLA class I and class II epitope precursors associated with heat shock protein 70 (HSPA)'. Cell Stress Chaperones, 15 (5):729-41. [Details]
Romano, D., Matallanas, D., Weitsman, G., Preisinger, C., Ng, T., Kolch, W. (2010) 'Proapoptotic kinase MST2 coordinates signaling crosstalk between RASSF1A, Raf-1, and Akt'. Cancer Res, 70 (3):1195-203. [Details]
Rauch, J., O'Neill, E., Mack, B., Matthias, C., Munz, M., Kolch, W., Gires, O. (2010) 'Heterogeneous nuclear ribonucleoprotein H blocks MST2-mediated apoptosis in cancer cells by regulating A-Raf transcription'. Cancer Res, 70 (4):1679-88. [Details]
Preisinger, C., Kolch, W. (2010) 'The Bcr-Abl kinase regulates the actin cytoskeleton via a GADS/Slp-76/Nck1 adaptor protein pathway'. Cell Signal, 22 (5):848-56. [Details]
Mischak, H., Kolch, W., Aivaliotis, M., Bouyssie, D., Court, M., Dihazi, H., Dihazi, G. H., Franke, J., Garin, J., Gonzalez de Peredo, A., Iphofer, A., Jansch, L., Lacroix, C., Makridakis, M., Masselon, C., Metzger, J., Monsarrat, B., Mrug, M., Norling, M., Novak, J., Pich, A., Pitt, A., Bongcam-Rudloff, E., Siwy, J., Suzuki, H., Thongboonkerd, V., Wang, L. S., Zoidakis, J., Zurbig, P., Schanstra, J. P., Vlahou, A. (2010) 'Comprehensive human urine standards for comparability and standardization in clinical proteome analysis'. Proteomics Clin Appl, 4 (4):464-78. [Details]
Mischak, H., Allmaier, G., Apweiler, R., Attwood, T., Baumann, M., Benigni, A., Bennett, S. E., Bischoff, R., Bongcam-Rudloff, E., Capasso, G., Coon, J. J., D'Haese, P., Dominiczak, A. F., Dakna, M., Dihazi, H., Ehrich, J. H., Fernandez-Llama, P., Fliser, D., Frokiaer, J., Garin, J., Girolami, M., Hancock, W. S., Haubitz, M., Hochstrasser, D., Holman, R. R., Ioannidis, J. P., Jankowski, J., Julian, B. A., Klein, J. B., Kolch, W., Luider, T., Massy, Z., Mattes, W. B., Molina, F., Monsarrat, B., Novak, J., Peter, K., Rossing, P., Sanchez-Carbayo, M., Schanstra, J. P., Semmes, O. J., Spasovski, G., Theodorescu, D., Thongboonkerd, V., Vanholder, R., Veenstra, T. D., Weissinger, E., Yamamoto, T., Vlahou, A. (2010) 'Recommendations for biomarker identification and qualification in clinical proteomics'. Sci Transl Med, 2 (46). Link to full text [Details]
Lock, F. E., Underhill-Day, N., Dunwell, T., Matallanas, D., Cooper, W., Hesson, L., Recino, A., Ward, A., Pavlova, T., Zabarovsky, E., Grant, M. M., Maher, E. R., Chalmers, A. D., Kolch, W., Latif, F. (2010) 'The RASSF8 candidate tumor suppressor inhibits cell growth and regulates the Wnt and NF-kappaB signaling pathways'. Oncogene, 29 (30):4307-16. [Details]
Kolch, W., Pitt, A. (2010) 'Functional proteomics to dissect tyrosine kinase signalling pathways in cancer'. Nature reviews. Cancer, 10 (9):618-29. [DOI] [Details]
Jiwaji, M., Daly, R., Pansare, K., McLean, P., Yang, J., Kolch, W., Pitt, A. R. (2010) 'The Renilla luciferase gene as a reference gene for normalization of gene expression in transiently transfected cells'. BMC Mol Biol, 11 :103. Link to full text [Details]
Dakna, M., Harris, K., Kalousis, A., Carpentier, S., Kolch, W., Schanstra, J. P., Haubitz, M., Vlahou, A., Mischak, H., Girolami, M. (2010) 'Addressing the challenge of defining valid proteomic biomarkers and classifiers'. BMC Bioinformatics, 11 :594. Link to full text [Details]
Wlodkowic, D., Skommer, J., McGuinness, D., Faley, S., Kolch, W., Darzynkiewicz, Z., Cooper, J. M. (2009) 'Chip-Based Dynamic Real-Time Quantification of Drug-Induced Cytotoxicity in Human Tumor Cells'. Anal.Chem, e-publication . [Details]
Schilling, M.Schilling, M.,Maiwald, T.Maiwald, T.,Hengl, S.Hengl, S.,Winter, D.Winter, D.,Kreutz, C.Kreutz, C.,Kolch, W.Kolch, W.,Lehmann, W. D.Lehmann, W. D.,Timmer, J.Timmer, J.,Klingmuller, U.Klingmuller, U.; (2009) 'Theoretical and experimental analysis links isoform-specific ERK signalling to cell fate decisions'. Mol Syst Biol, 5 :334334. [Details]
Aebersold, R.Aebersold, R.,Auffray, C.Auffray, C.,Baney, E.Baney, E.,Barillot, E.Barillot, E.,Brazma, A.Brazma, A.,Brett, C.Brett, C.,Brunak, S.Brunak, S.,Butte, A.Butte, A.,Califano, A.Califano, A.,Celis, J.Celis, J.,Cufer, T.Cufer, T.,Ferrell, J.Ferrell, J.,Galas, D.Galas, D.,Gallahan, D.Gallahan, D.,Gatenby, R.Gatenby, R.,Goldbeter, A.Goldbeter, A.,Hace, N.Hace, N.,Henney, A.Henney, A.,Hood, L.Hood, L.,Iyengar, R.Iyengar, R.,Jackson, V.Jackson, V.,Kallioniemi, O.Kallioniemi, O.,Klingmuller, U.Klingmuller, U.,Kolar, P.Kolar, P.,Kolch, W.Kolch, W.,Kyriakopoulou, C.Kyriakopoulou, C.,Laplace, F.Laplace, F.,Lehrach, H.Lehrach, H.,Marcus, F.Marcus, F.,Matrisian, L.Matrisian, L.,Nolan, G.Nolan, G.,Pelkmans, L.Pelkmans, L.,Potti, A.Potti, A.,Sander, C.Sander, C.,Seljak, M.Seljak, M.,Singer, D.; (2009) 'Report on EU-USA workshop: how systems biology can advance cancer research (27 October 2008)'. Mol.Oncol, 3 (11):9-179. [Details]
Cooper, W. N.Cooper, W. N.,Hesson, L. B.Hesson, L. B.,Matallanas, D.Matallanas, D.,Dallol, A.Dallol, A.,von, Kriegsheim A.von, Kriegsheim A.,Ward, R.Ward, R.,Kolch, W.Kolch, W.,Latif, F.Latif, F.; (2009) 'RASSF2 associates with and stabilizes the proapoptotic kinase MST2'. Oncogene, 28 (3333):2988-29982988. [Details]
von Kriegsheim, A., Baiocchi, D., Birtwistle, M., Sumpton, D., Bienvenut, W., Morrice, N., Yamada, K., Lamond, A., Kalna, G., Orton, R., Gilbert, D., Kolch, W. (2009) 'Cell fate decisions are specified by the dynamic ERK interactome'. Nat Cell Biol, 11 (12):1458-64. [Details]
Vera, J., Kwon, T., Schmitz, U., Kolch, W. (2009) 'Exploration of homodimer receptor: homodimer protein interactions'. Int.J Bioinform.Res.Appl, 5 (4):447-457. [Details]
Shin, S. Y., Rath, O., Choo, S. M., Fee, F., McFerran, B., Kolch, W., Cho, K. H. (2009) 'Positive- and negative-feedback regulations coordinate the dynamic behavior of the Ras-Raf-MEK-ERK signal transduction pathway'. J Cell Sci, 122 (Pt 3):425-435. [Details]
Orton, R. J., Adriaens, M. E., Gormand, A., Sturm, O. E., Kolch, W., Gilbert, D. R. (2009) 'Computational modelling of cancerous mutations in the EGFR/ERK signalling pathway'. BMC Syst Biol, 3 :100. Link to full text [Details]
Nikolov, S., Vera, J., Rath, O., Kolch, W., Wolkenhauer, O. (2009) 'Role of inhibitory proteins as modulators of oscillations in NFB signalling'. IET Syst.Biol, 3 (2):59-76. [Details]
Kim, D., Kolch, W., Cho, K. H. (2009) 'Multiple roles of the NF-kappaB signaling pathway regulated by coupled negative feedback circuits'. FASEB J, 23 (9):2796-2802. [Details]
Garcia, R., Grindlay, J., Rath, O., Fee, F., Kolch, W. (2009) 'Regulation of human myoblast differentiation by PEBP4'. EMBO Rep, 10 (3):278-284. [Details]
Faley, S. L., Copland, M., Wlodkowic, D., Kolch, W., Seale, K. T., Wikswo, J. P., Cooper, J. M. (2009) 'Microfluidic single cell arrays to interrogate signalling dynamics of individual, patient-derived hematopoietic stem cells'. Lab Chip, 9 (18):2659-2664. [Details]
Doyle,B., Hagan,S, Scott,L., O'Sullivan, J., Mulcahy,H.E., Sheehan,K., Kolch, W. (2009) 'Down-Regulation of RKIP Predicts a Worse Outcome in Dukes B Colorectal Carcinoma. Is This Down-Regulation Due to Hypermethylation? 2009; : 572 '. Modern Pathology, 22 . [Details]
Dhillon, A. S., Yip, Y. Y., Grindlay, G. J., Pakay, J. L., Dangers, M., Hillmann, M., Clark, W., Pitt, A., Mischak, H., Kolch, W. (2009) 'The C-terminus of Raf-1 acts as a 14-3-3-dependent activation switch'. Cell Signal, 21 (11):1645-1651. [Details]
Densham, R., O'Neill, E., Munro, J., Konig, I., Anderson, K., Kolch, W., Olson, M. F. (2009) 'MST kinases monitor actin cytoskeletal integrity and signal via JNK stress-activated kinase to regulate p21Waf1/Cip1 stability'. Mol Cell Biol, . [Details]
Dallol, A., Hesson, L. B., Matallanas, D., Cooper, W. N., O'Neill, E., Maher, E. R., Kolch, W., Latif, F. (2009) 'RAN GTPase is a RASSF1A effector involved in controlling microtubule organization'. Curr.Biol, 19 (14):1227-1232. [Details]
Dakna, M., He, Z., Yu, W. C., Mischak, H., Kolch, W. (2009) 'Technical, bioinformatical and statistical aspects of liquid chromatography-mass spectrometry (LC-MS) and capillary electrophoresis-mass spectrometry (CE-MS) based clinical proteomics: a critical assessment'. J Chromatogr.B Analyt.Technol.Biomed.Life Sci, 877 (13):1250-1258. [Details]
Xu, T. R., Baillie, G. S., Bhari, N., Houslay, T. M., Pitt, A. M., Adams, D. R., Kolch, W., Houslay, M. D., Milligan, G. (2008) 'Mutations of beta-arrestin 2 that limit self-association also interfere with interactions with the beta2-adrenoceptor and the ERK1/2 MAP kinases: Implications for beta2-adrenoceptor-signalling via the ERK1/2 MAP kinases'. Biochem.J, 413 :51-60. [Details]
Orton, R. J.Orton, R. J.,Sturm, O. E.Sturm, O. E.,Gormand, A.Gormand, A.,Kolch, W.Kolch, W.,Gilbert, D. R.Gilbert, D. R.; (2008) 'Computational modelling reveals feedback redundancy within the EGFR/ERK signalling pathway'. IET Systems Biology, 2 :173-183173. [Details]
Coon, J. J.Coon, J. J.,Zurbig, P.Zurbig, P.,Dakna, M.Dakna, M.,Dominiczak, A. F.Dominiczak, A. F.,Decramer, S.Decramer, S.,Fliser, D.Fliser, D.,Frommberger, M.Frommberger, M.,Golovko, I.Golovko, I.,Good, D. M.Good, D. M.,Herget-Rosenthal, S.Herget-Rosenthal, S.,Jankowski, J.Jankowski, J.,Julian, B. A.Julian, B. A.,Kellmann, M.Kellmann, M.,Kolch, W.Kolch, W.,Massy, Z.Massy, Z.,Novak, J.Novak, J.,Rossing, K.Rossing, K.,Schanstra, J. P.Schanstra, J. P.,Schiffer, E.Schiffer, E.,Theodorescu, D.Theodorescu, D.,Vanholder, R.Vanholder, R.,Weissinger, E. M.Weissinger, E. M.,Mischak, H.Mischak, H.,Schmitt-Kopplin, P.Schmitt-Kopplin, P.; (2008) 'CE-MS analysis of the human urinary proteome for biomarker discovery and disease diagnostics'. Proteomics Clinical Applications, 2 :964-973964. [Details]
Zimmerli, L. U.Zimmerli, L. U.,Schiffer, E.Schiffer, E.,Zurbig, P.Zurbig, P.,Good, D. M.Good, D. M.,Kellmann, M.Kellmann, M.,Mouls, L.Mouls, L.,Pitt, A. R.Pitt, A. R.,Coon, J. J.Coon, J. J.,Schmieder, R. E.Schmieder, R. E.,Peter, K. H.Peter, K. H.,Mischak, H.Mischak, H.,Kolch, W.Kolch, W.,Delles, C.Delles, C.,Dominiczak, A. F.Dominiczak, A. F.; (2008) 'Urinary proteomic biomarkers in coronary artery disease'. Mol Cell Proteomics, 7 (22):290-298290. [Details]
von Kriegsheim, A.von Kriegsheim, A.,Preisinger, C.Preisinger, C.,Kolch, W.Kolch, W.; (2008) 'Mapping of signaling pathways by functional interaction proteomics'. Methods Mol.Biol, 484:177-92 :177-192177. [Details]
Vera, J.Vera, J.,Millat, T.Millat, T.,Kolch, W.Kolch, W.,Wolkenhauer, O.Wolkenhauer, O.; (2008) 'Dynamics of receptor and protein transducer homodimerisation'. BMC.Syst.Biol, 2 (11):9292. [Details]
Sedgwick, H.Sedgwick, H.,Caron, F.Caron, F.,Monaghan, P. B.Monaghan, P. B.,Kolch, W.Kolch, W.,Cooper, J. M.Cooper, J. M.; (2008) 'Lab-on-a-chip technologies for proteomic analysis from isolated cells'. J R.Soc.Interface, 5 Suppl 2:S123-30 . [Details]
Preisinger C, von Kriegsheim A, Matallanas D, Kolch W; (2008) 'Proteomics and phosphoproteomics for the mapping of cellular signalling networks'. Proteomics, 8 (21):4402-4415. [DOI] [Details]
Kholodenko BN, Kolch W; (2008) 'Giving space to cell signaling'. Cell, 133 (4):566-567. [DOI] [Details]
Rogers, S., Girolami, M., Kolch, W., Waters, K. M., Liu, T., Thrall, B., Wiley, H. S. (2008) 'Investigating the correspondence between transcriptomic and proteomic expression profiles using coupled cluster models'. Bioinformatics, . [Details]
Rath, O., Park, S., Tang, H. H., Banfield, M. J., Brady, R. L., Lee, Y. C., Dignam, J. D., Sedivy, J. M., Kolch, W., Yeung, K. C. (2008) 'The RKIP (Raf-1 Kinase Inhibitor Protein) conserved pocket binds to the phosphorylated N-region of Raf-1 and inhibits the Raf-1-mediated activated phosphorylation of MEK'. Cell Signal, 20 (5):935-941. [Details]
Patek, C. E., Arends, M. J., Wallace, W. A., Luo, F., Hagan, S., Brownstein, D. G., Rose, L., Devenney, P. S., Walker, M., Plowman, S. J., Berry, R. L., Kolch, W., Sansom, O. J., Harrison, D. J., Hooper, M. L. (2008) 'Mutationally activated K-ras 4A and 4B both mediate lung carcinogenesis'. Exp.Cell Res, 314 (5):1105-1114. [Details]
Matallanas, D., Romano, D., Hamilton, G., Kolch, W., O'Neill, E. (2008) 'A Hippo in the ointment: MST signalling beyond the fly'. Cell Cycle, 7 (7):879-884. [Details]
Kolch, W. (2008) 'Defining systems biology: through the eyes of a biochemist'. IET.Syst.Biol, 2 (1):5-7. [Details]
Beach, S., Tang, H., Park, S., Dhillon, A. S., Keller, E. T., Kolch, W., Yeung, K. C. (2008) 'Snail is a repressor of RKIP transcription in metastatic prostate cancer cells'. Oncogene, 27 (15):2243-2248. [Details]
Al-Mulla, F., Hagan, S., Al-Ali, W., Jacob, S. P., Behbehani, A. I., Bitar, M. S., Dallol, A., Kolch, W. (2008) 'Raf kinase inhibitor protein: mechanism of loss of expression and association with genomic instability'. J Clin.Pathol, 61 (4):524-529. [Details]
Matallanas, D., Romano, D., Yee, K., Meissl, K., Kucerova, L., Piazzolla, D., Baccarini, M., Vass, J. K., Kolch, W., O'Neill, E. (2007) 'RASSF1A elicits apoptosis through an MST2 pathway directing proapoptotic transcription by the p73 tumor suppressor protein'. Mol.Cell, 27 (6):962-975. [Details]
Murray, E.Murray, E.,McKenna, E. O.McKenna, E. O.,Burch, L. R.Burch, L. R.,Dillon, J.Dillon, J.,Langridge-Smith, P.Langridge-Smith, P.,Kolch, W.Kolch, W.,Pitt, A.Pitt, A.,Hupp, T. R.Hupp, T. R.; (2007) 'Microarray-formatted clinical biomarker assay development using peptide aptamers to anterior gradient-2'. Biochemistry, 46 (4848):13742-1375113742. [Details]
Millington, M.Millington, M.,Grindlay, G. J.Grindlay, G. J.,Altenbach, K.Altenbach, K.,Neely, R. K.Neely, R. K.,Kolch, W.Kolch, W.,Bencina, M.Bencina, M.,Read, N. D.Read, N. D.,Jones, A. C.Jones, A. C.,Dryden, D. T.Dryden, D. T.,Magennis, S. W.Magennis, S. W.; (2007) 'High-precision FLIM-FRET in fixed and living cells reveals heterogeneity in a simple CFP-YFP fusion protein'. Biophys.Chem, 127 (33):155-164155. [Details]
Kim, D.Kim, D.,Rath, O.Rath, O.,Kolch, W.Kolch, W.,Cho, K. H.Cho, K. H.; (2007) 'A hidden oncogenic positive feedback loop caused by crosstalk between Wnt and ERK pathways'. Oncogene, 26 (3131):4571-45794571. [Details]
Hindley, A.Hindley, A.,Kolch, W.Kolch, W.; (2007) 'Raf-1 and B-Raf promote protein kinase C theta interaction with BAD'. Cell Signal, 19 (33):547-555547. [Details]
Dhillon, A. S.Dhillon, A. S.,von Kriegsheim, A.von Kriegsheim, A.,Grindlay, J.Grindlay, J.,Kolch, W.Kolch, W.; (2007) 'Phosphatase and feedback regulation of Raf-1 signaling'. Cell Cycle, 6 (11):3-73. [Details]
Dhillon, A. S., Hagan, S., Rath, O., Kolch, W. (2007) 'MAP kinase signalling pathways in cancer'. Oncogene, 26 (22):3279-3290. [Details]
von Kriegsheim, A., Pitt, A., Grindlay, G. J., Kolch, W., Dhillon, A. S. (2006) 'Regulation of the Raf-MEK-ERK pathway by protein phosphatase 5'. Nat.Cell Biol, 8 (9):1011-1016. [Details]
Spickett, C. M., Pitt, A. R., Morrice, N., Kolch, W. (2006) 'Proteomic analysis of phosphorylation, oxidation and nitrosylation in signal transduction'. Biochim.Biophys.Acta, 1764 :1823-1841. [Details]
Rushworth, L. K., Hindley, A. D., O'Neill, E., Kolch, W. (2006) 'Regulation and role of Raf-1/B-Raf heterodimerization'. Mol.Cell Biol, 26 (6):2262-2272. [Details]
Park, S., Rath, O., Beach, S., Xiang, X., Kelly, S. M., Luo, Z., Kolch, W., Yeung, K. C. (2006) 'Regulation of RKIP binding to the N-region of the Raf-1 kinase'. FEBS Lett, 580 (27):6405-6412. [Details]
Gloeckner, C. J., Kinkl, N., Schumacher, A., Braun, R. J., O'Neill, E., Meitinger, T., Kolch, W., Prokisch, H., Ueffing, M. (2006) 'The Parkinson disease causing LRRK2 mutation I2020T is associated with increased kinase activity'. Hum.Mol.Genet, 15 (2):223-232. [Details]
Bilsland, A. E., Stevenson, K., Atkinson, S., Kolch, W., Keith, W. N. (2006) 'Transcriptional repression of telomerase RNA gene expression by c-Jun-NH2-kinase and Sp1/Sp3'. Cancer Res, 66 (3):1363-1370. [Details]
Al-Mulla, F., Hagan, S., Behbehani, A. I., Bitar, M. S., George, S. S., Going, J. J., Garcia, J. J., Scott, L., Fyfe, N., Murray, G. I., Kolch, W. (2006) 'Raf kinase inhibitor protein expression in a survival analysis of colorectal cancer patients'. J Clin.Oncol, 24 (36):5672-5679. [Details]
Sakaki, Y., Kholodenko, B. N., Hatakeyama, M., Kitano, H., Kolch, W., De, Meyts P., Yarden, Y., Westerhoff, H. V., Wiley, H. S. (2005) 'The International Consortium on Systems Biology of Receptor Tyrosine Kinase Regulatory Networks'. Syst.Biol.(Stevenage.), 152 (2):53-54. [Details]
Pollock, C. B.Pollock, C. B.,Shirasawa, S.Shirasawa, S.,Sasazuki, T.Sasazuki, T.,Kolch, W.Kolch, W.,Dhillon, A. S.Dhillon, A. S.; (2005) 'Oncogenic K-RAS is required to maintain changes in cytoskeletal organization, adhesion, and motility in colon cancer cells'. Cancer Res, 65 (44):1244-12501244. [Details]
O'Neill, E. E.O'Neill, E. E.,Matallanas, D.Matallanas, D.,Kolch, W.Kolch, W.; (2005) 'Mammalian sterile 20-like kinases in tumor suppression: an emerging pathway'. Cancer Res, 65 (1313):5485-54875485. [Details]
Kolch, W.Kolch, W.,Neususs, C.Neususs, C.,Pelzing, M.Pelzing, M.,Mischak, H.Mischak, H.; (2005) 'Capillary electrophoresis-mass spectrometry as a powerful tool in clinical diagnosis and biomarker discovery'. Mass Spectrom.Rev, 24 (66):959-977959. [Details]
Kolch, W.Kolch, W.,Mischak, H.Mischak, H.,Pitt, A. R.Pitt, A. R.; (2005) 'The molecular make-up of a tumour: proteomics in cancer research'. Clin.Sci.(Lond), 108 (55):369-383369. [Details]
Baral, C.Baral, C.,Kolch, W.Kolch, W.,Shankland, C.Shankland, C.,Tran, N.Tran, N.; (2005) 'Reasoning about the ERK signal transduction pathway using BioSigNet-RR'. Proceedings of Computational Methods in Systems Biology, CMSB 2005 :79-9079. [Details]
Wittke, S.Wittke, S.,Mischak, H.Mischak, H.,Walden, M.Walden, M.,Kolch, W.Kolch, W.,Radler, T.Radler, T.,Wiedemann, K.Wiedemann, K.; (2005) 'Discovery of biomarkers in human urine and cerebrospinal fluid by capillary electrophoresis coupled to mass spectrometry: towards new diagnostic and therapeutic approaches'. Electrophoresis, 26 (7-87-8):1476-14871476. [Details]
Orton, R. J., Sturm, O. E., Vyshemirsky, V., Calder, M., Gilbert, D. R., Kolch, W. (2005) 'Computational modelling of the receptor-tyrosine-kinase-activated MAPK pathway'. Biochem.J, 392 (Pt 2):249-261. [Details]
O'Neill, E., Kolch, W. (2005) 'Taming the Hippo: Raf-1 controls apoptosis by suppressing MST2/Hippo'. Cell Cycle, 4 (3):365-367. [Details]
Kolch, W., Calder, M., Gilbert, D. (2005) 'When kinases meet mathematics: the systems biology of MAPK signalling'. FEBS Lett, 579 (8):1891-1895. [Details]
Kolch, W. (2005) 'Coordinating ERK/MAPK signalling through scaffolds and inhibitors'. Nat.Rev.Mol.Cell Biol, 6 (11):827-837. [Details]
Hagan, S., Al Mulla, F., Mallon, E., Oien, K., Ferrier, R., Gusterson, B., Garcia, J. J., Kolch, W. (2005) 'Reduction of Raf-1 kinase inhibitor protein expression correlates with breast cancer metastasis'. Clin.Cancer Res, 11 (20):7392-7397. [Details]
Wolkenhauer, O., Ullah, M., Kolch, W., Cho, K. H. (2004) 'Modeling and simulation of intracellular dynamics: choosing an appropriate framework'. IEEE Trans.Nanobioscience, 3 (3):200-207. [Details]
O'Neill, E.O'Neill, E.,Rushworth, L.Rushworth, L.,Baccarini, M.Baccarini, M.,Kolch, W.Kolch, W.; (2004) 'Role of the kinase MST2 in suppression of apoptosis by the proto-oncogene product Raf-1'. Science, 306 (57055705):2267-22702267. [Details]
Neuhoff, N.Neuhoff, N.,Kaiser, T.Kaiser, T.,Wittke, S.Wittke, S.,Krebs, R.Krebs, R.,Pitt, A.Pitt, A.,Burchard, A.Burchard, A.,Sundmacher, A.Sundmacher, A.,Schlegelberger, B.Schlegelberger, B.,Kolch, W.Kolch, W.,Mischak, H.Mischak, H.; (2004) 'Mass spectrometry for the detection of differentially expressed proteins: a comparison of surface-enhanced laser desorption/ionization and capillary electrophoresis/mass spectrometry'. Rapid Commun.Mass Spectrom, 18 (22):149-156149. [Details]
Wolkenhauer, O., Cho, K. H., Kolch, W. (2004) 'Systems Biology: Towards an understanding of the Dynamics of Life'. Bioforum Europe, 1 :50-53. [Details]
Weissinger, E. M., Oettrich, K., Evans, C., Genieser, H. G., Schwede, F., Dangers, M., Dammann, E., Kolb, H. J., Mischak, H., Ganser, A., Kolch, W. (2004) 'Activation of protein kinase A (PKA) by 8-Cl-cAMP as a novel approach for antileukaemic therapy'. Br.J.Cancer, 91 (1):186-192. [Details]
Schuierer, M. M., Bataille, F., Hagan, S., Kolch, W., Bosserhoff, A. K. (2004) 'Reduction in Raf kinase inhibitor protein expression is associated with increased Ras-extracellular signal-regulated kinase signaling in melanoma cell lines'. Cancer Res, 64 (15):5186-5192. [Details]
O'Neill, E., Kolch, W. (2004) 'Conferring specificity on the ubiquitous Raf/MEK signalling pathway'. Br.J.Cancer, 90 (2):283-288. [Details]
Kolch, W., Mischak, H., Chalmers, M. J., Pitt, A., Marshall, A. G. (2004) 'Clinical proteomics: a question of technology'. Rapid Commun.Mass Spectrom, 18 (19):2365. [Details]
Kirchner, S., Boldt, S., Kolch, W., Haffner, S., Kazak, S., Janosch, P., Holler, E., Andreesen, R., Eissner, G. (2004) 'LPS resistance in monocytic cells caused by reverse signaling through transmembrane TNF (mTNF) is mediated by the MAPK/ERK pathway'. J.Leukoc.Biol, 75 (2):324-331. [Details]
Hindley, A. D., Park, S., Wang, L., Shah, K., Wang, Y., Hu, X., Shokat, K. M., Kolch, W., Sedivy, J. M., Yeung, K. C. (2004) 'Engineering the serine/threonine protein kinase Raf-1 to utilise an orthogonal analogue of ATP substituted at the N6 position'. FEBS Lett, 556 (1-3):26-34. [Details]
Eissner, G., Kolch, W., Scheurich, P. (2004) 'Ligands working as receptors: reverse signaling by members of the TNF superfamily enhance the plasticity of the immune system'. Cytokine Growth Factor Rev, 15 (5):353-366. [Details]
Dhillon, A. S., Kolch, W. (2004) 'Oncogenic B-Raf mutations: crystal clear at last'. Cancer Cell, 5 (4):303-304. [Details]
Chalmers, M. J., Kolch, W., Emmett, M. R., Marshall, A. G., Mischak, H. (2004) 'Identification and analysis of phosphopeptides'. J.Chromatogr.B Analyt.Technol.Biomed.Life Sci, 803 (1):111-120. [Details]
Boldt, S., Kolch, W. (2004) 'Targeting MAPK signalling: Prometheus' fire or Pandora's box?'. Curr.Pharm.Des, 10 (16):1885-1905. [Details]
Kolch, W. (2003) 'Erbin: sorting out ErbB2 receptors or giving Ras a break?'. Sci.STKE, . [Details]
Gross, C.Gross, C.,Koelch, W.Koelch, W.,DeMaio, A.DeMaio, A.,Arispe, N.Arispe, N.,Multhoff, G.Multhoff, G.; (2003) 'Cell surface-bound heat shock protein 70 (Hsp70) mediates perforin-independent apoptosis by specific binding and uptake of granzyme B'. J.Biol Chem, 278 (4242):41173-4118141173. [Details]
Dhillon, A. S., Meikle, S., Peyssonnaux, C., Grindlay, J., Kaiser, C., Steen, H., Shaw, P. E., Mischak, H., Eychene, A., Kolch, W. (2003) 'A Raf-1 mutant that dissociates MEK/extracellular signal-regulated kinase activation from malignant transformation and differentiation but not proliferation'. Mol.Cell Biol, 23 (6):1983-1993. [Details]
Cho, K. H., Shin, S. Y., Kolch, W., Wolkenhauer, O. (2003) 'Experimental Design in Systems Biology Based on Parameter Sensitivity Analysis with Monte Carlo Simulation: A Case Study for the TNFalpha Mediated NF-kappaB Signal Transduction Pathway'. Simulation, 79 :726-739. [Details]
Boldt, S., Weidle, U. H., Kolch, W. (2003) 'The kinase domain of MEKK1 induces apoptosis by dysregulation of MAP kinase pathways'. Exp.Cell Res, 283 (1):80-90. [Details]
Kolch, W., Kotwaliwale, A., Vass, K., Janosch, P. (2002) 'The role of Raf kinases in malignant transformation'. Expert Rev.Mol.Med, 2002 :1-18. Available Online [Details]
Dhillon, A. S.Dhillon, A. S.,Meikle, S.Meikle, S.,Yazici, Z.Yazici, Z.,Eulitz, M.Eulitz, M.,Kolch, W.Kolch, W.; (2002) 'Regulation of Raf-1 activation and signalling by dephosphorylation'. EMBO J, 21 (1-21-2):64-7164. [Details]
Dhillon, A. S.Dhillon, A. S.,Kolch, W.Kolch, W.; (2002) 'Untying the regulation of the Raf-1 kinase'. Arch.Biochem.Biophys, 404 (11):3-93. [Details]
Dartsch, D. C.Dartsch, D. C.,Schaefer, A.Schaefer, A.,Boldt, S.Boldt, S.,Kolch, W.Kolch, W.,Marquardt, H.Marquardt, H.; (2002) 'Comparison of anthracycline-induced death of human leukemia cells: programmed cell death versus necrosis'. Apoptosis, 7 (66):537-548537. [Details]
Kolch, W. (2002) 'Ras/Raf signalling and emerging pharmacotherapeutic targets'. Expert Opin.Pharmacother, 3 (6):709-718. [Details]
Hindley, A., Kolch, W. (2002) 'Extracellular signal regulated kinase (ERK)/mitogen activated protein kinase (MAPK)-independent functions of Raf kinases'. J.Cell Sci, 115 (Pt 8):1575-1581. [Details]
Goerke, A., Sakai, N., Gutjahr, E., Schlapkohl, W. A., Mushinski, J. F., Haller, H., Kolch, W., Saito, N., Mischak, H. (2002) 'Induction of apoptosis by protein kinase C delta is independent of its kinase activity'. J.Biol Chem, 277 (35):32054-32062. [Details]
Dhillon, A. S., Pollock, C., Steen, H., Shaw, P. E., Mischak, H., Kolch, W. (2002) 'Cyclic AMP-dependent kinase regulates Raf-1 kinase mainly by phosphorylation of serine 259'. Mol.Cell Biol, 22 (10):3237-3246. [Details]
Boldt, S., Weidle, U. H., Kolch, W. (2002) 'The role of MAPK pathways in the action of chemotherapeutic drugs'. Carcinogenesis, 23 (11):1831-1838. [Details]
Yeung, K. C.Yeung, K. C.,Rose, D. W.Rose, D. W.,Dhillon, A. S.Dhillon, A. S.,Yaros, D.Yaros, D.,Gustafsson, M.Gustafsson, M.,Chatterjee, D.Chatterjee, D.,McFerran, B.McFerran, B.,Wyche, J.Wyche, J.,Kolch, W.Kolch, W.,Sedivy, J. M.Sedivy, J. M.; (2001) 'Raf kinase inhibitor protein interacts with NF-kappaB-inducing kinase and TAK1 and inhibits NF-kappaB activation'. Mol.Cell Biol, 21 (2121):7207-72177207. [Details]
Kolch, W.Kolch, W.; (2001) 'To be or not to be: a question of B-Raf?'. Trends Neurosci, 24 (99):498-500498. [Details]
Kao, S.Kao, S.,Jaiswal, R. K.Jaiswal, R. K.,Kolch, W.Kolch, W.,Landreth, G. E.Landreth, G. E.; (2001) 'Identification of the mechanisms regulating the differential activation of the mapk cascade by epidermal growth factor and nerve growth factor in PC12 cells'. J.Biol Chem, 276 (2121):18169-1817718169. [Details]
Yeung, K., Janosch, P., McFerran, B., Rose, D. W., Mischak, H., Sedivy, J. M., Kolch, W. (2000) 'Mechanism of suppression of the Raf/MEK/extracellular signal-regulated kinase pathway by the raf kinase inhibitor protein'. Mol.Cell Biol, 20 (9):3079-3085. [Details]
Kolch, W.Kolch, W.; (2000) 'Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions'. Biochem.J, 351 Pt 2:289-305 :289-305289. [Details]
Houslay, M. D.Houslay, M. D.,Kolch, W.Kolch, W.; (2000) 'Cell-type specific integration of cross-talk between extracellular signal-regulated kinase and cAMP signaling'. Mol.Pharmacol, 58 (44):659-668659. [Details]
Dammeier, S.Dammeier, S.,Lovric, J.Lovric, J.,Eulitz, M.Eulitz, M.,Kolch, W.Kolch, W.,Mushinski, J. F.Mushinski, J. F.,Mischak, H.Mischak, H.; (2000) 'Identification of the smooth muscle-specific protein, sm22, as a novel protein kinase C substrate using two-dimensional gel electrophoresis and mass spectrometry'. Electrophoresis, 21 (1212):2443-24532443. [Details]
Baumann, M.Baumann, M.,Gires, O.Gires, O.,Kolch, W.Kolch, W.,Mischak, H.Mischak, H.,Zeidler, R.Zeidler, R.,Pich, D.Pich, D.,Hammerschmidt, W.Hammerschmidt, W.; (2000) 'The PKC targeting protein RACK1 interacts with the Epstein-Barr virus activator protein BZLF1'. Eur.J.Biochem, 267 (1212):3891-39013891. [Details]
Janosch, P., Kieser, A., Eulitz, M., Lovric, J., Sauer, G., Reichert, M., Gounari, F., Buscher, D., Baccarini, M., Mischak, H., Kolch, W. (2000) 'The Raf-1 kinase associates with vimentin kinases and regulates the structure of vimentin filaments'. FASEB J, 14 (13):2008-2021. [Details]
Eissner, G., Kirchner, S., Lindner, H., Kolch, W., Janosch, P., Grell, M., Scheurich, P., Andreesen, R., Holler, E. (2000) 'Reverse signaling through transmembrane TNF confers resistance to lipopolysaccharide in human monocytes and macrophages'. J.Immunol, 164 (12):6193-6198. [Details]
Abraham, D., Podar, K., Pacher, M., Kubicek, M., Welzel, N., Hemmings, B. A., Dilworth, S. M., Mischak, H., Kolch, W., Baccarini, M. (2000) 'Raf-1-associated protein phosphatase 2A as a positive regulator of kinase activation'. J.Biol Chem, 275 (29):22300-22304. [Details]
Vichi, P.Vichi, P.,Whelchel, A.Whelchel, A.,Knot, H.Knot, H.,Nelson, M.Nelson, M.,Kolch, W.Kolch, W.,Posada, J.Posada, J.; (1999) 'Endothelin-stimulated ERK activation in airway smooth-muscle cells requires calcium influx and Raf activation'. Am.J.Respir.Cell Mol.Biol, 20 (11):99-10599. [Details]
Yeung, K.Yeung, K.,Seitz, T.Seitz, T.,Li, S.Li, S.,Janosch, P.Janosch, P.,McFerran, B.McFerran, B.,Kaiser, C.Kaiser, C.,Fee, F.Fee, F.,Katsanakis, K. D.Katsanakis, K. D.,Rose, D. W.Rose, D. W.,Mischak, H.Mischak, H.,Sedivy, J. M.Sedivy, J. M.,Kolch, W.Kolch, W.; (1999) 'Suppression of Raf-1 kinase activity and MAP kinase signalling by RKIP'. Nature, 401 (67496749):173-177173. [Details]
Muller, G., Storz, P., Bourteele, S., Doppler, H., Pfizenmaier, K., Mischak, H., Philipp, A., Kaiser, C., Kolch, W. (1998) 'Regulation of Raf-1 kinase by TNF via its second messenger ceramide and cross-talk with mitogenic signalling'. EMBO J, 17 (3):732-742. [Details]
Prouty, S. M.Prouty, S. M.,Maroo, A.Maroo, A.,Maucher, C.Maucher, C.,Mischak, H.Mischak, H.,Kolch, W.Kolch, W.,Sedivy, J. M.Sedivy, J. M.; (1998) 'Studies of perinuclear and nuclear translocation of the Raf-1 protein in rodent fibroblasts'. Biochim.Biophys.Acta, 1402 (11):6-166. [Details]
Maucher, C.Maucher, C.,Weissinger, E. M.Weissinger, E. M.,Kremmer, E.Kremmer, E.,Baccarini, M.Baccarini, M.,Procyk, K.Procyk, K.,Henderson, D. W.Henderson, D. W.,Wolff, L.Wolff, L.,Kolch, W.Kolch, W.,Kaspers, B.Kaspers, B.,Mushinski, J. F.Mushinski, J. F.,Mischak, H.Mischak, H.; (1998) 'Activation of bcl-2 suppressible 40 and 44 kDa p38-like kinases during apoptosis of early and late B lymphocytic cell lines'. FEBS Lett, 427 (11):29-3529. [Details]
Lovric, J.Lovric, J.,Dammeier, S.Dammeier, S.,Kieser, A.Kieser, A.,Mischak, H.Mischak, H.,Kolch, W.Kolch, W.; (1998) 'Activated raf induces the hyperphosphorylation of stathmin and the reorganization of the microtubule network'. J.Biol Chem, 273 (3535):22848-2285522848. [Details]
Rose, D. W.Rose, D. W.,Xiao, S.Xiao, S.,Pillay, T. S.Pillay, T. S.,Kolch, W.Kolch, W.,Olefsky, J. M.Olefsky, J. M.; (1998) 'Prolonged versus transient roles for early cell cycle signaling components'. Oncogene, 17 (77):889-899889. [Details]
Baumann, M., Mischak, H., Dammeier, S., Kolch, W., Gires, O., Pich, D., Zeidler, R., Delecluse, H. J., Hammerschmidt, W. (1998) 'Activation of the Epstein-Barr virus transcription factor BZLF1 by 12-O-tetradecanoylphorbol-13-acetate-induced phosphorylation'. J.Virol, 72 (10):8105-8114. [Details]
Weissinger, E. M., Eissner, G., Grammer, C., Fackler, S., Haefner, B., Yoon, L. S., Lu, K. S., Bazarov, A., Sedivy, J. M., Mischak, H., Kolch, W. (1997) 'Inhibition of the Raf-1 kinase by cyclic AMP agonists causes apoptosis of v-abl-transformed cells'. Mol.Cell Biol, 17 (6):3229-3241. [Details]
Kieser, A.Kieser, A.,Kilger, E.Kilger, E.,Gires, O.Gires, O.,Ueffing, M.Ueffing, M.,Kolch, W.Kolch, W.,Hammerschmidt, W.Hammerschmidt, W.; (1997) 'Epstein-Barr virus latent membrane protein-1 triggers AP-1 activity via the c-Jun N-terminal kinase cascade'. EMBO J, 16 (2121):6478-64856478. [Details]
Ueffing, M.Ueffing, M.,Lovric, J.Lovric, J.,Philipp, A.Philipp, A.,Mischak, H.Mischak, H.,Kolch, W.Kolch, W.; (1997) 'Protein kinase C-epsilon associates with the Raf-1 kinase and induces the production of growth factors that stimulate Raf-1 activity'. Oncogene, 15 (2424):2921-29272921. [Details]
Mischak, H., Seitz, T., Janosch, P., Eulitz, M., Steen, H., Schellerer, M., Philipp, A., Kolch, W. (1996) 'Negative regulation of Raf-1 by phosphorylation of serine 621'. Mol.Cell Biol, 16 (10):5409-5418. [Details]
Kieser, A.Kieser, A.,Seitz, T.Seitz, T.,Adler, H. S.Adler, H. S.,Coffer, P.Coffer, P.,Kremmer, E.Kremmer, E.,Crespo, P.Crespo, P.,Gutkind, J. S.Gutkind, J. S.,Henderson, D. W.Henderson, D. W.,Mushinski, J. F.Mushinski, J. F.,Kolch, W.Kolch, W.,Mischak, H.Mischak, H.; (1996) 'Protein kinase C-zeta reverts v-raf transformation of NIH-3T3 cells'. Genes Dev, 10 (1212):1455-14661455. [Details]
Janosch, P.Janosch, P.,Schellerer, M.Schellerer, M.,Seitz, T.Seitz, T.,Reim, P.Reim, P.,Eulitz, M.Eulitz, M.,Brielmeier, M.Brielmeier, M.,Kolch, W.Kolch, W.,Sedivy, J. M.Sedivy, J. M.,Mischak, H.Mischak, H.; (1996) 'Characterization of IkappaB kinases. IkappaB-alpha is not phosphorylated by Raf-1 or protein kinase C isozymes, but is a casein kinase II substrate'. J.Biol Chem, 271 (2323):13868-1387413868. [Details]
Eissner, G.Eissner, G.,Lindner, H.Lindner, H.,Behrends, U.Behrends, U.,Kolch, W.Kolch, W.,Hieke, A.Hieke, A.,Klauke, I.Klauke, I.,Bornkamm, G. W.Bornkamm, G. W.,Holler, E.Holler, E.; (1996) 'Influence of bacterial endotoxin on radiation-induced activation of human endothelial cells in vitro and in vivo: protective role of IL-10'. Transplantation, 62 (66):819-827819. [Details]
Cacace, A. M.Cacace, A. M.,Ueffing, M.Ueffing, M.,Philipp, A.Philipp, A.,Han, E. K.Han, E. K.,Kolch, W.Kolch, W.,Weinstein, I. B.Weinstein, I. B.; (1996) 'PKC epsilon functions as an oncogene by enhancing activation of the Raf kinase'. Oncogene, 13 (1212):2517-25262517. [Details]
Kolch, W., Philipp, A., Mischak, H., Dutil, E. M., Mullen, T. M., Feramisco, J. R., Meinkoth, J. L., Rose, D. W. (1996) 'Inhibition of Raf-1 signaling by a monoclonal antibody, which interferes with Raf-1 activation and with Mek substrate binding'. Oncogene, 13 (6):1305-1314. [Details]
Jaiswal, R. K., Weissinger, E., Kolch, W., Landreth, G. E. (1996) 'Nerve growth factor-mediated activation of the mitogen-activated protein (MAP) kinase cascade involves a signaling complex containing B-Raf and HSP90'. J.Biol Chem, 271 (39):23626-23629. [Details]
Kolch, W., Martiny-Baron, G., Kieser, A., Marme, D. (1995) 'Regulation of the expression of the VEGF/VPS and its receptors: role in tumor angiogenesis'. Breast Cancer Res Treat, 36 (2):139-155. [Details]
Li, S.Li, S.,Janosch, P.Janosch, P.,Tanji, M.Tanji, M.,Rosenfeld, G. C.Rosenfeld, G. C.,Waymire, J. C.Waymire, J. C.,Mischak, H.Mischak, H.,Kolch, W.Kolch, W.,Sedivy, J. M.Sedivy, J. M.; (1995) 'Regulation of Raf-1 kinase activity by the 14-3-3 family of proteins'. EMBO J, 14 (44):685-696685. [Details]
Goodnight, J. A.Goodnight, J. A.,Mischak, H.Mischak, H.,Kolch, W.Kolch, W.,Mushinski, J. F.Mushinski, J. F.; (1995) 'Immunocytochemical localization of eight protein kinase C isozymes overexpressed in NIH 3T3 fibroblasts. Isoform-specific association with microfilaments, Golgi, endoplasmic reticulum, and nuclear and cell membranes'. J.Biol Chem, 270 (1717):9991-100019991. [Details]
Kieser, A., Goodnight, J., Kolch, W., Mischak, H., Mushinski, J. F. (1995) 'Identification of the primary growth response gene, ST2/T1, as a gene whose expression is differentially regulated by different protein kinase C isozymes'. FEBS Lett, 372 (2-3):189-193. [Details]
Kieser, A., Weich, H. A., Brandner, G., Marme, D., Kolch, W. (1994) 'Mutant p53 potentiates protein kinase C induction of vascular endothelial growth factor expression'. Oncogene, 9 (3):963-969. [Details]
Moodie, S. A.Moodie, S. A.,Paris, M. J.Paris, M. J.,Kolch, W.Kolch, W.,Wolfman, A.Wolfman, A.; (1994) 'Association of MEK1 with p21ras.GMPPNP is dependent on B-Raf'. Mol.Cell Biol, 14 (1111):7153-71627153. [Details]
Hafner, S.Hafner, S.,Adler, H. S.Adler, H. S.,Mischak, H.Mischak, H.,Janosch, P.Janosch, P.,Heidecker, G.Heidecker, G.,Wolfman, A.Wolfman, A.,Pippig, S.Pippig, S.,Lohse, M.Lohse, M.,Ueffing, M.Ueffing, M.,Kolch, W.Kolch, W.; (1994) 'Mechanism of inhibition of Raf-1 by protein kinase A'. Mol.Cell Biol, 14 (1010):6696-67036696. [Details]
Kazanietz, M. G., Bustelo, X. R., Barbacid, M., Kolch, W., Mischak, H., Wong, G., Pettit, G. R., Bruns, J. D., Blumberg, P. M. (1994) 'Zinc finger domains and phorbol ester pharmacophore. Analysis of binding to mutated form of protein kinase C zeta and the vav and c-raf proto-oncogene products'. J.Biol Chem, 269 (15):11590-11594. [Details]
Eissner, G., Kolch, W., Mischak, H., Bornkamm, G. W., Holler, E. (1994) 'Differential role of protein kinase C in cytokine induced lymphocyte-endothelium interaction in vitro'. Scand.J.Immunol, 40 (4):395-402. [Details]
Brennscheidt, U., Riedel, D., Kolch, W., Bonifer, R., Brach, M. A., Ahlers, A., Mertelsmann, R. H., Herrmann, F. (1994) 'Raf-1 is a necessary component of the mitogenic response of the human megakaryoblastic leukemia cell line MO7 to human stem cell factor, granulocyte-macrophage colony-stimulating factor, interleukin 3, and interleukin 9'. Cell Growth Differ, 5 (4):367-372. [Details]
Kolch, W.Kolch, W.,Heidecker, G.Heidecker, G.,Kochs, G.Kochs, G.,Hummel, R.Hummel, R.,Vahidi, H.Vahidi, H.,Mischak, H.Mischak, H.,Finkenzeller, G.Finkenzeller, G.,Marme, D.Marme, D.,Rapp, U. R.Rapp, U. R.; (1993) 'Protein kinase C alpha activates RAF-1 by direct phosphorylation'. Nature, 364 (64346434):249-252249. [Details]
Mischak, H.Mischak, H.,Goodnight, J. A.Goodnight, J. A.,Kolch, W.Kolch, W.,Martiny-Baron, G.Martiny-Baron, G.,Schaechtle, C.Schaechtle, C.,Kazanietz, M. G.Kazanietz, M. G.,Blumberg, P. M.Blumberg, P. M.,Pierce, J. H.Pierce, J. H.,Mushinski, J. F.Mushinski, J. F.; (1993) 'Overexpression of protein kinase C-delta and -epsilon in NIH 3T3 cells induces opposite effects on growth, morphology, anchorage dependence, and tumorigenicity'. J.Biol Chem, 268 (99):6090-60966090. [Details]
Kolch, W.Kolch, W.,Heidecker, G.Heidecker, G.,Troppmair, J.Troppmair, J.,Yanagihara, K.Yanagihara, K.,Bassin, R. H.Bassin, R. H.,Rapp, U. R.Rapp, U. R.; (1993) 'Raf revertant cells resist transformation by non-nuclear oncogenes and are deficient in the induction of early response genes by TPA and serum'. Oncogene, 8 (22):361-370361. [Details]
Heidecker, G.Heidecker, G.,Kolch, W.Kolch, W.,Morrison, D. K.Morrison, D. K.,Rapp, U. R.Rapp, U. R.; (1992) 'The role of Raf-1 phosphorylation in signal transduction'. Adv.Cancer Res, 58:53-73 :53-7353. [Details]
Mischak, H., Bodenteich, A., Kolch, W., Goodnight, J., Hofer, F., Mushinski, J. F. (1991) 'Mouse protein kinase C-delta, the major isoform expressed in mouse hemopoietic cells: sequence of the cDNA, expression patterns, and characterization of the protein'. Biochemistry, 30 (32):7925-7931. [Details]
Mischak, H.Mischak, H.,Kolch, W.Kolch, W.,Goodnight, J.Goodnight, J.,Davidson, W. F.Davidson, W. F.,Rapp, U.Rapp, U.,Rose-John, S.Rose-John, S.,Mushinski, J. F.Mushinski, J. F.; (1991) 'Expression of protein kinase C genes in hemopoietic cells is cell-type- and B cell-differentiation stage specific'. J.Immunol, 147 (1111):3981-39873981. [Details]
Qureshi, S. A.Qureshi, S. A.,Rim, M.Rim, M.,Bruder, J.Bruder, J.,Kolch, W.Kolch, W.,Rapp, U.Rapp, U.,Sukhatme, V. P.Sukhatme, V. P.,Foster, D. A.Foster, D. A.; (1991) 'An inhibitory mutant of c-Raf-1 blocks v-Src-induced activation of the Egr-1 promoter'. J.Biol Chem, 266 (3131):20594-2059720594. [Details]
Kolch, W., Heidecker, G., Lloyd, P., Rapp, U. R. (1991) 'Raf-1 protein kinase is required for growth of induced NIH/3T3 cells'. Nature, 349 (6308):426-428. [Details]
Kolch, W., Weissinger, E., Mischak, H., Troppmair, J., Showalter, S. D., Lloyd, P., Heidecker, G., Rapp, U. R. (1990) 'Probing structure and function of the raf protein kinase domain with monoclonal antibodies'. Oncogene, 5 (5):713-720. [Details]
Mischak, H.Mischak, H.,Kolch, W.Kolch, W.,Hofer, F.Hofer, F.,Weissinger, E.Weissinger, E.,Gessl, A.Gessl, A.,Davidson, W. F.Davidson, W. F.,Aiello, F. B.Aiello, F. B.,Blaas, D.Blaas, D.,Rapp, U. R.Rapp, U. R.; (1990) 'A raf/myc virus immortalized macrophage cell line which supports the growth of B-cell and B-cell hybridomas'. Oncogene, 5 (99):1377-13821377. [Details]
Heidecker, G.Heidecker, G.,Huleihel, M.Huleihel, M.,Cleveland, J. L.Cleveland, J. L.,Kolch, W.Kolch, W.,Beck, T. W.Beck, T. W.,Lloyd, P.Lloyd, P.,Pawson, T.Pawson, T.,Rapp, U. R.Rapp, U. R.; (1990) 'Mutational activation of c-raf-1 and definition of the minimal transforming sequence'. Mol.Cell Biol, 10 (66):2503-25122503. [Details]
Sithanandam, G.Sithanandam, G.,Kolch, W.Kolch, W.,Duh, F. M.Duh, F. M.,Rapp, U. R.Rapp, U. R.; (1990) 'Complete coding sequence of a human B-raf cDNA and detection of B-raf protein kinase with isozyme specific antibodies'. Oncogene, 5 (1212):1775-17801775. [Details]
Kolch, W., Schultz, A. M., Oppermann, H., Rapp, U. R. (1988) 'Preparation of raf-oncogene-specific antiserum with raf protein produced in E. coli'. Biochim.Biophys.Acta, 949 (2):233-239. [Details]
Kolch, W., Bonner, T. I., Rapp, U. R. (1988) 'Expression of human c-raf-1 oncogene proteins in E. coli'. Biochem.Biophys.Res Commun, 152 (3):1045-1049. [Details]
                                                                                                   

Published abstracts

Kolch W, Fey D, Halasz M, Rauch N, Munoz AG, Pilkington R, Kholodenko BN, Croucher DR, Kennedy SP, Hastings JF, Westermann F, Dreidax D, Fischer M, Duffy D, Krstic A, Schwarzl T. (2015) Personalized cancer diagnostics and therapeutics based on the computational modelling of signal transduction networks. Published abstracts [Details]
           

Comment

Bastiaens P, Birtwistle MR;Bl¿¿thgen N;Bruggeman FJ;Cho KH;Cosentino C;de la Fuente A;Hoek JB;Kiyatkin A;Klamt S;Kolch W;Legewie S;Mendes P;Naka T;Santra T;Sontag E;Westerhoff HV;Kholodenko BN (2015) Silence on the relevant literature and errors in implementation. Comment [DOI] [Details]
                       

Research

Research Interests

Current Research Interests

·  Role of the Ras-Raf-MEK-ERK pathway in malignant transformation. The main focus is on using quantitative proteomics to characterise dynamically changing signalling complexes in response to mitogenic stimuli. The strategy has resulted in the discovery of new regulators and effectors of Raf and ERK signalling, e.g. MST2. It also has shown that whole signalling pathways can be mapped by tracking dynamically changing protein interactions. We want to expand this approach to investigate changes in cell signalling during invasion, differentiation and apoptosis, and as result of genetic mutations in oncogenes and tumour suppressor genes.

·  Regulation of the MST2/Hippo pathway. According to our results MST2 coordinates proliferation signals from the Raf pathway with pro-apoptotic signals from the RASSF1A tumour suppressor gene. Using the above proteomics approach we have mapped a six step pathway from Fas at the cell membrane to p73 dependent transcription in the nucleus. We are further characterising this pathway, in particular with respect to whether and how it can be exploited for targeted tumour therapy.

·  Characterisation of RKIP. We have cloned this protein a decade ago as the first physiological inhibitor protein of Raf kinases. It has turned out to play a major role in metastasis suppression, a function which is probably independent from its ability to inhibit ERK activation. We are investigating the molecular mechanism of RKIP functions using cellular models, mouse models, and clinical studies.

· Systems biology of cell signalling. We are using mathematical and computational modelling to analyse the network structure of cell signalling. The aim is to predict responses to perturbations (such as drugs), define the most sensitive points for interference by drugs, and analyse the specificity of signalling and adaptation processes.

· Translational research based on taking advantages on the opportunities arising from mechanistic insights gained from a strong basic research programme, such as diagnostic tests for metastasis risk; or identification and validation of new drug targets.

Research Projects

Sponsor : Science Foundation Ireland (SFI)
AbbVie
Title : Usage of Omics Technology for Identification of Critical Mediators and Pathways in Patients with Recalcitrant Atopic Dermatitis, Psoriasis and Hidrenitis Suppurvativa
Start Date / End Date : 01-APR-16 / 01-APR-19
Sponsor : Science Foundation Ireland (SFI)
Title : Next Generation Ex-vivo Functional Predictive Assays for High Grade Serous Ovarian Cancer Screening: Three Dimensional, Multicellular Drug Screening using Lab on a Chip Technologies
Start Date / End Date : 01-JAN-17 / 31-DEC-17
Sponsor : Complix N.V.
Title : Production and characterization of recombinant RAF pathway proteins for the generation of alphabodies by biopanning
Start Date / End Date : 01-MAY-16 / 01-NOV-17
Sponsor : Science Foundation Ireland (SFI)
Title : Quantitative and systems analysis of (patho)physiological signalling networks
Start Date / End Date : 01-SEP-17 / 01-SEP-22
Sponsor : Science Foundation Ireland (SFI)
AbbVie
Title : Usage of Omics Technology for Identification of Critical Mediators and Pathways in Patients with Recalcitrant Atopic Dermatitis, Psoriasis and Hidrenitis Suppurvativa LINKED TO RESEARCH ACCOUNTS R15899,R15900,R15901
Start Date / End Date : 01-APR-16 / 01-APR-19
Sponsor : Amgen
Title : Developing a Competitive Process to Recognize and Celebrate ABE Teachers
Start Date / End Date : 01-FEB-17 / 30-APR-17
Sponsor : Amgen
Title : Exploring the International Expansion of ABE-Partner Selection
Start Date / End Date : 01-NOV-16 / 30-JUN-17
Sponsor : Science Foundation Ireland (SFI)
Title : Stokes Professorship
Start Date / End Date : 31-JAN-09 / 30-JAN-14
Sponsor : Science Foundation Ireland (SFI)
Title : Systems Biology Ireland
Start Date / End Date : 01-JUN-09 / 31-MAY-15
Sponsor : Science Foundation Ireland (SFI)
Title : Systems Biology Ireland
Start Date / End Date : 01-JUN-09 / 31-MAY-15
Sponsor : European Commission FP6
Title : Identification, development and validation of novel targeting programmed cell death in tumors (GROWTHSTOP)
Start Date / End Date : 01-FEB-10 / 31-MAR-11
Sponsor : AstraZeneca UK Ltd.
Title : CRC50: Modelling synergistic combinations
Start Date / End Date : 13-NOV-09 / 31-MAY-12
Sponsor : EC Framework (FP7)
Title : BioSpec - How biochemical networks encode biological specificity: Modulation of cell migration by isoform specific ERK and Akt signaling
Start Date / End Date : 31-AUG-09 / 28-FEB-11
Sponsor : Higher Education Authority (HEA)
Title : National Programme on (Bio)pharmaceutical & Pharmacological Sciences
Start Date / End Date : 01-OCT-09 / 31-DEC-10
Sponsor : Failte Ireland
Title : Support for ESF SBI-LCSB Confences and Summer Schools/Workshops in Systems Medicine
Start Date / End Date : 01-JAN-11 / 31-DEC-11
Sponsor : University College Dublin (UCD)
Title : ITFoM (IT Future of Medicine) project preparation
Start Date / End Date : 17-SEP-12 / 31-MAY-13
Sponsor : EC Framework (FP7)
Title : Infrastructure for Systems Biology - Europe (ISBE)
Start Date / End Date : 01-AUG-12 / 31-JUL-15
Sponsor : Bayer Schering Pharma AG, Germany
Title : From Targets to Novel Drugs
Start Date / End Date : 28-NOV-12 / 01-JAN-15
Sponsor : Amgen
Title : Amgen Biotech Experience Programme 2015-2017
Start Date / End Date : 01-JUL-15 / 31-DEC-17
Sponsor : Science Foundation Ireland (SFI)
Title : SIRG: Crosstalk between ErbB2 and breast cancer associated receptor tyrosine kinases in resistance to ErbB2 target therapies
Start Date / End Date : 01-MAY-12 / 30-SEP-16
Sponsor : EC Framework (FP7)
Title : Systems Biology to Identify Molecular Targets for Vascular Disease Treatment (SysVasc)
Start Date / End Date : 01-FEB-14 / 31-JAN-18
Sponsor : EC Framework (FP7)
Title : CASyM¿ Coordinating Action Systems Medicine ¿ Implementation of Systems Medicine
Start Date / End Date : 01-NOV-12 / 30-APR-17
Sponsor : Irish Cancer Society (ICS)
Title : Collaborative Cancer Research Centre: From population to patient: Leveraging systems medicine to personalise breast cancer treatment (ICS BREAST PREDICT)
Start Date / End Date : 01-OCT-13 / 30-SEP-18
Sponsor : The Wellcome Trust (WT)
Title : The Impact of Genetic Heterogeneity on Synthetic Lethality in Cancer
Start Date / End Date : 02-JUL-14 / 01-JUL-18
Sponsor : HORIZON 2020
Title : Exploiting MELanoma disease comPLEXity to address European research training needs in translational cancer systems biology and cancer systems medicine (MEL-PLEX)
Start Date / End Date : 01-DEC-14 / 30-NOV-18
Sponsor : Science Foundation Ireland (SFI)
Title : Overcoming Drug Resistance in Metastatic Malignant Melanoma by Personalizing Treatment
Start Date / End Date : 01-SEP-15 / 01-SEP-20
Sponsor : University College Dublin Foundation Ltd.
Title : Amgen Foundation EQ250714
Start Date / End Date : 01-AUG-14 / 31-JUL-16
Sponsor : HORIZON 2020
Title : Fellowship Programme supporting Career Development and Interdisciplinary Training in Omics driven Personalised Medicine (TOPMED10)
Start Date / End Date : 01-JUL-15 / 30-JUN-20
Sponsor : Science Foundation Ireland (SFI)
Title : 15/FELLOWSHIP/1021
Start Date / End Date : 20-JUL-15 / 19-JUL-17
Sponsor : Science Foundation Ireland (SFI)
Title : 15/Fellowship/1020
Start Date / End Date : 14-SEP-15 / 13-SEP-17
Sponsor : EC Framework (FP7)
Title : PRIMES: Protein interaction machines in oncogenic EGF receptor signalling
Start Date / End Date : 01-DEC-11 / 30-NOV-16
Sponsor : Teagasc
Title : Developing Network Analyisis Approaches to Discover Master Regulators of the Host Response to Bovine Infectious Dieases
Start Date / End Date : 01-FEB-13 / 31-JAN-17
Sponsor : EC Framework (FP7)
Title : ASSET: Analysing and Striking the Sensitivities of Embryonal Tumours
Start Date / End Date : 01-NOV-10 / 30-APR-16
 

Current Postgraduate Students

Shannon Lee, Doctor of Philosophy (PhD)   -   Thesis Supervisor
Zhi Liu, Doctor of Philosophy (PhD)   -   Thesis Supervisor
Estefania Chiquero-Leon, Doctor of Philosophy (PhD)   -   Thesis Supervisor
Elisa Panada, Doctor of Philosophy (PhD)   -   Thesis Supervisor
Fernando Martinez, Doctor of Philosophy (PhD)   -   Thesis Supervisor
Laura Tuffery, Doctor of Philosophy (PhD)   -   Thesis Supervisor
Stephanie Mc Kenna, Doctor of Philosophy (PhD)   -   Thesis Supervisor