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Walter McNicholas

Newman Clinical Research Professor/Full Professor

School of Medicine
Department of Respiratory Medicine
St. Vincent's University Hospital
Elm Park
Dublin 4

Tel: 353 1 2213702
Email: walter.mcnicholas@ucd.ie

Biography

Professor Walter McNicholas is Newman Clinical Research Professor at UCD and a Principal Clinical Investigator at the UCD Conway Institute. He is also Director of the Pulmonary and Sleep Disorders Unit and Consultant Respiratory Physician at St. Vincent¿s University Hospital, Dublin. He is a medical graduate of UCD (1974) and following a Research Fellowship in Respiratory Sleep Disorders at the University of Toronto, he established a clinical and research laboratory at St. Vincent¿s Hospital in 1984. The Unit provides a National Referral service for patients with sleep-disordered breathing and has developed an internationally renowned translational research programme investigating the mechanisms and consequences of obstructive sleep apnoea, particularly relating to the effects of intermittent hypoxia, and the cardiometabolic consequences of the disorder. The core members of the research group at St. Vincent¿s and the Conway Institute include Dr. Silke Ryan MD PhD, HRB Senior Fellow and Locum Consultant, and Ms. Geraldine Lawless MSc, Chief Respiratory Scientist.

Prof. McNicholas is a past Associate Editor of the European Respiratory Journal, and has published over 200 papers in Pub-Med listed Journals (h-index: 40 in the Web of Science; 53 in Google Scholar), in addition to more than 30 book chapters, and has edited 3 textbooks on breathing disorders during sleep. He serves on the Editorial Boards of several International Respiratory and Sleep Journals.

Prof. McNicholas has held many Leadership positions in National and International organisations, particularly as President of the European Respiratory Society (2003-2004) and is Vice President of the European Sleep Research Society (2012-2016) and President of the European Board of Accreditation in Pneumology (2010-2014). He Chaired a COST Action (B26) on Obstructive Sleep Apnoea (2005-2010), and recently chaired a Working Group established by the European Commission on Driving Risk in Sleep Apnoea that resulted in a formal EU Directive regulating the ability of patients with sleep apnoea to hold a driving license, which became mandatory for all EU member states in January 2016.Professor Walter McNicholas is Newman Clinical Research Professor at UCD and a Principal Clinical Investigator at the UCD Conway Institute. He is also Director of the Pulmonary and Sleep Disorders Unit and Consultant Respiratory Physician at St. Vincent¿s University Hospital, Dublin. He is a medical graduate of UCD (1974) and following a Research Fellowship in Respiratory Sleep Disorders at the University of Toronto, he established a clinical and research laboratory at St. Vincent¿s Hospital in 1984. The Unit provides a National Referral service for patients with sleep-disordered breathing and has developed an internationally renowned translational research programme investigating the mechanisms and consequences of obstructive sleep apnoea, particularly relating to the effects of intermittent hypoxia, and the cardiometabolic consequences of the disorder. The core members of the research group at St. Vincent¿s and the Conway Institute include Dr. Silke Ryan MD PhD, HRB Senior Fellow and Locum Consultant, and Ms. Geraldine Lawless MSc, Chief Respiratory Scientist.

Prof. McNicholas is a past Associate Editor of the European Respiratory Journal, and has published over 200 papers in Pub-Med listed Journals (h-index: 40 in the Web of Science; 53 in Google Scholar), in addition to more than 30 book chapters, and has edited 3 textbooks on breathing disorders during sleep. He serves on the Editorial Boards of several International Respiratory and Sleep Journals.

Prof. McNicholas has held many Leadership positions in National and International organisations, particularly as President of the European Respiratory Society (2003-2004) and is Vice President of the European Sleep Research Society (2012-2016) and President of the European Board of Accreditation in Pneumology (2010-2014). He Chaired a COST Action (B26) on Obstructive Sleep Apnoea (2005-2010), and recently chaired a Working Group established by the European Commission on Driving Risk in Sleep Apnoea that resulted in a formal EU Directive regulating the ability of patients with sleep apnoea to hold a driving license, which became mandatory for all EU member states in January 2016.                                                                    

Professional

Honours and Awards

Year: 2015.
Title: Cournand Lecture, European Respiratory Society Annual Congress (Dr Silke Ryan)

Associations

Association: American Academy of Sleep Medicine, Function/Role: Member
Association: American Thoracic Society, Function/Role: Member
Association: European Sleep Research Society, Function/Role: Member
Association: European Respiratory Society, Function/Role: Member
     

Conference Contributions

Sheridan, E., Heneghan, C., Nolan, P., Cullen, J., McNicholas, W., OMalley, M. J.,; Detection and analysis of electrocardiogram interval variations in normal sinus rhythm,. [National Refereed Conference Paper], Proceedings of the Irish Colloquim on DSP and Control, Dublin, July, 2000, Dublin .
Cullen, J.,Lowery, M.,McNicholas, W. T.,Nolan, P.,O'Malley, M.,O'Muircheartaigh, C.; (2001) XXXIV International Congress of Physiological Sciences. [Published Abstract], Optimisation of Electrode Design to Detect Myoelectric Manifestations of Fatigue in the Human Genioglossus Muscle, Christchurch, New Zealand .
           

Journals Edited

Journal Of Thoracic Disease: Reviewer.
 

Publications

Books

G. Parati, C. Lombardi, J. Hedner, M.R. Bonsignore, L. Grote, R. Tkacova, P. Levy, R. Riha, C. Bassetti, K. Narkiewicz, , G. Mancia, W. McNicholas. ; (2010) Consensus document on the management of patients with obstructive sleep apnea and hypertension. Joint recommendations by the European Cost Action B26, the European Society of Hypertension and the European Respiratory Society. Momento Medico (Salerno, Italy): Momento Medico. [Details]
McNicholas WT, Bonsignore MR (Ed.). (2010) Sleep Apnoea . sheffield: European Respiratory Society. [Details]
WT McNicholas and EA Phillipson (Ed.). (2002) Breathing Disorders in Sleep (A clinical textbook). London: WB Saunders Ltd. [Details]

Book Chapters

Bonsignore MR, McNicholas W.; (2009) 'PP179-204' In: Bonsignore MR, McNicholas W.; (eds). Sleep-disordered breathing in the elderly. Respir Monograph 2009; 43: 179-204: Eur Respir Monograph. [Details]
de Chazal P, Heneghan C, Chua CP, Shouldice R, Ryan S, McNicholas W. (2007) 'Home- Based Assessment of Sleep Apnoea using Simultaneous Electrocardiogram and Oximetry Signals' In: Robert T. Ferber (eds). Progress in Sleep Apnea Research. New York, USA: Nova Science Publishers. [Details]

Edited Books

Edited by Walter T. McNicholas and Marisa Bonsignore (Ed.). (2010) Sleep Apnoea. European Respiratory Monograph Series: European Respiratory Monograph Series. [Details]

Peer Reviewed Journals

Bonsignore MR, Randerath W;Riha R;Smyth D;Gratziou C;Gon¿¿alves M;McNicholas WT (2016) 'New rules on driver licensing for patients with obstructive sleep apnea: European Union Directive 2014/85/EU'. Journal of Sleep Research, 25 (1):3-4. [DOI] [Details]
L¿¿vy P, Kohler M;McNicholas WT;Barb¿¿ F;McEvoy RD;Somers VK;Lavie L;P¿¿pin JL (2016) 'Obstructive sleep apnoea syndrome'. Nature reviews. Disease primers, 1 . [DOI] [Details]
McNicholas WT (2016) 'Chronic obstructive pulmonary disease and obstructive sleep apnoea-the overlap syndrome'. Journal of Thoracic Disease, 8 (2):236-242. [DOI] [Details]
Mitchell S, Simonds A;Andreas S;Bonsignore MR;Cooper B;Donic V;McNicholas WT;Morrell M;Palange P;Prest G;Riha R;Trang H;Randerath W;van der Grinten C;Verbraecken J;de Backer W (2015) 'Introducing a core curriculum for respiratory sleep practitioners'. Breathe, 11 (1):50-56. [DOI] [Details]
Gon¿¿alves M, Amici R;Lucas R;¿¿kerstedt T;Cirignotta F;Horne J;L¿¿ger D;McNicholas WT;Partinen M;T¿¿ran-Santos J;Peigneux P;Grote L (2015) 'Sleepiness at the wheel across Europe: a survey of 19 countries'. Journal of Sleep Research, 24 (3):242-253. [DOI] [Details]
McNicholas WT, Luo Y;Zhong N (2015) 'Sleep apnoea: a major and under-recognised public health concern'. Journal of Thoracic Disease, 7 (8):1269-1272. [DOI] [Details]
Escourrou P, Grote L;Penzel T;Mcnicholas WT;Verbraecken J;Tkacova R;Riha RL;Hedner J; (2015) 'The diagnostic method has a strong influence on classification of obstructive sleep apnea'. Journal of Sleep Research, 24 (6):730-738. [DOI] [Details]
McNicholas WT, Rodenstein D (2015) 'Sleep apnoea and driving risk: the need for regulation'. European Respiratory Review, 24 (138):602-606. [DOI] [Details]
Gaoatswe G, Kent BD;Corrigan MA;Nolan G;Hogan AE;McNicholas WT;O'Shea D (2015) 'Invariant Natural Killer T Cell Deficiency and Functional Impairment in Sleep Apnea: Links to Cancer Comorbidity'. Sleep, 38 (10):1629-1634. [DOI] [Details]
Arnardottir ES, Verbraecken J;Gon¿¿alves M;Gjerstad MD;Grote L;Puertas FJ;Mihaicuta S;McNicholas WT;Parrino L (2015) 'Variability in recording and scoring of respiratory events during sleep in Europe: a need for uniform standards'. Journal of Sleep Research, . [DOI] [Details]
Kent BD, McNicholas WT;Ryan S (2015) 'Insulin resistance, glucose intolerance and diabetes mellitus in obstructive sleep apnoea'. Journal of Thoracic Disease, 7 (8):1343-1357. [DOI] [Details]
Lee RN, Kelly E;Nolan G;Eigenheer S;Boylan D;Murphy D;Dodd J;Keane MP;McNicholas WT (2015) 'Disordered breathing during sleep and exercise in idiopathic pulmonary fibrosis and the role of biomarkers'. Qjm-An International Journal Of Medicine, 108 (4):315-323. [DOI] [Details]
Taylor CT, Kent BD;Crinion SJ;McNicholas WT;Ryan S (2014) 'Human adipocytes are highly sensitive to intermittent hypoxia induced NF-kappaB activity and subsequent inflammatory gene expression'. Biochemical and Biophysical Research Communications, 447 (4):660-665. [DOI] [Details]
Ryan S, Crinion SJ;McNicholas WT (2014) 'Obesity and sleep-disordered breathing--when two 'bad guys' meet'. Qjm-An International Journal Of Medicine, 107 (12):949-954. [DOI] [Details]
Tkacova R, McNicholas WT;Javorsky M;Fietze I;Sliwinski P;Parati G;Grote L;Hedner J; (2014) 'Nocturnal intermittent hypoxia predicts prevalent hypertension in the European Sleep Apnoea Database cohort study'. European Respiratory Journal, 44 (4):931-941. [DOI] [Details]
Pallin M, O'Hare E;Zaffaroni A;Boyle P;Fagan C;Kent B;Heneghan C;de Chazal P;McNicholas WT (2014) 'Comparison of a novel non-contact biomotion sensor with wrist actigraphy in estimating sleep quality in patients with obstructive sleep apnoea'. Journal of Sleep Research, 23 (4):475-484. [DOI] [Details]
Kent BD, Grote L;Bonsignore MR;Saaresranta T;Verbraecken J;L¿¿vy P;Sliwinski P;Tkacova R;Kvamme JA;Fietze I;Hedner J;McNicholas WT; (2014) 'Sleep apnoea severity independently predicts glycaemic health in nondiabetic subjects: the ESADA study'. European Respiratory Journal, 44 (1):130-139. [DOI] [Details]
Zaffaroni A, Kent B;O'Hare E;Heneghan C;Boyle P;O'Connell G;Pallin M;de Chazal P;McNicholas WT (2013) 'Assessment of sleep-disordered breathing using a non-contact bio-motion sensor'. Journal of Sleep Research, 22 (2):231-236. [DOI] [Details]
Kent BD, Garvey JF;Ryan S;Nolan G;Dodd JD;McNicholas WT (2013) 'Severity of obstructive sleep apnoea predicts coronary artery plaque burden: a coronary computed tomographic angiography study'. European Respiratory Journal, 42 (5):1263-1270. [DOI] [Details]
McNicholas WT, Verbraecken J, Marin JM (2013) 'Sleep disorders in COPD: the forgotten dimension'. European Respiratory Review, 22 (129):365-375. [DOI] [Details]
McSharry D, O'Connor C, McNicholas T, Langran S, O'Sullivan M, Lowery M, McNicholas WT (2012) 'Genioglossus fatigue in obstructive sleep apnea'. Respiratory Physiology and Neurobiology, . [DOI] [Details]
McSharry DG, Ryan S;Calverley P;Edwards JC;McNicholas WT (2012) 'Sleep quality in chronic obstructive pulmonary disease'. Respirology, 17 (7):1119-1124. [DOI] [Details]
Hedner J, Grote L, Bonsignore M, McNicholas W, Lavie P, Parati G, Sliwinski P, Barbé F, De Backer W, Escourrou P, Fietze I, Kvamme JA, Lombardi C, Marrone O, Masa JF, Montserrat JM, Penzel T, Pretl M, Riha R, Rodenstein D, Saaresranta T, Schulz R, Tkacova R, Varoneckas G, Vitols A, Vrints H, Zielinski J (2011) 'The European Sleep Apnoea Database (ESADA): report from 22 European sleep laboratories'. EUR RESPIR J, 38 (3):635-642. [DOI] [Details]
Kent BD, Ryan S, McNicholas WT (2011) 'Obstructive sleep apnea and inflammation: relationship to cardiovascular co-morbidity'. Respiratory Physiology and Neurobiology, 178 (3):475-481. [DOI] [Details]
Kent BD, Mitchell PD, McNicholas WT (2011) 'Hypoxemia in patients with COPD: cause, effects, and disease progression'. International journal of chronic obstructive pulmonary disease, 6 :199-208. [DOI] [Details]
Ryan, S,Garvey, JF,Swan, V,Behan, R,McNicholas, WT; (2011) 'Nasal pillows as an alternative interface in patients with obstructive sleep apnoea syndrome initiating continuous positive airway pressure therapy'. Journal of Sleep Research, 20 :367-373. [DOI] [Details]
Lee, R,McNicholas, WT; (2011) 'Obstructive sleep apnea in chronic obstructive pulmonary disease patients'. Current Opinion in Pulmonary Medicine, 17 :79-83. [DOI] [Details]
Shouldice RB, Heneghan C, Petres G, Zaffaroni A, Boyle P, McNicholas W, de Chazal P (2010) 'Real time breathing rate estimation from a non contact biosensor'. IEEE Engineering in Medicine and Biology Magazine, 2010 :630-633. [DOI] [Details]
Garvey JF, McNicholas WT.; (2010) 'Continuous positive airway pressure therapy: new generations'. The Indian journal of medical research, 131 :259-266. [Details]
Miller SD, Glynn SF, Kiely JL, McNicholas WT.; (2010) 'The role of nasal CPAP in obstructive sleep apnoea syndrome due to mandibular hypoplasia'. Respirology (Carlton, Vic.), 15 (2):377-379. [Details]
Ryan S, McNicholas W.; (2010) 'The effect of continuous positive airway pressure on C-reactive protein levels in patients with obstructive sleep apnea syndrome'. Chest, 137 (2):496-497. [Details]
Kent BD, Ryan S, McNicholas WT; (2010) 'The genetics of obstructive sleep apnoea'. Current opinion in pulmonary medicine, 16 (6):536-542. [Details]
Ryan S, Garvey JF, Swan V, Behan R, McNicholas WT; (2010) 'Nasal pillows as an alternative interface in patients with obstructive sleep apnoea syndrome initiating continuous positive airway pressure therapy'. Journal of Sleep Research, . [Details]
de Chazal P, Fox N, O'Hare E, Heneghan C, Zaffaroni A, Boyle P, Smith S, O'Connell C, McNicholas WT.; (2010) 'Sleep/wake measurement using a non-contact biomotion sensor'. Journal of Sleep Research, . [Details]
O' Donnell DH, Phelan S, McNicholas W, Gallagher CG, Crotty T, Dodd JD (2010) 'Idiopathic lymphocytic pleuritis: radiographic and high-resolution CT appearances and changes in response to therapy in two adults'. Clinical Imaging, 34 (3):226-230. [DOI] [Details]
Zaffaroni A, de Chazal P, Heneghan C, Boyle P, Mppm PR, McNicholas WT. ; (2009) 'SleepMinder: an innovative contact-free device for the estimation of the apnoea-hypopnoea index'. Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference, 2009:7091-4 . [Details]
McNicholas WT, ; (2009) 'Obstructive sleep apnea and inflammation'. Progress in Cardiovascular Diseases, 5 (NA):392-399. [DOI] [Details]
Ryan, S,Doherty, LS,Nolan, GM,McNicholas, WT; (2009) 'Effects of Heated Humidification and Topical Steroids on Compliance, Nasal Symptoms, and Quality of Life in Patients with Obstructive Sleep Apnea Syndrome Using Nasal Continuous Positive Airway Pressure'. Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 5 :422-427. [Details]
Ryan, S.,McNicholas, W. T.; (2009) 'Inflammatory cardiovascular risk markers in obstructive sleep apnoea syndrome'. Cardiovasc Hematol Agents Med Chem, 7 (1):76-81. Available Online [Details]
Ryan, S.,Doherty, L. S.,Rock, C.,Nolan, G. M.,McNicholas, W. T.; (2009) 'Effects of Salmeterol on Sleeping Oxygen Saturation in Chronic Obstructive Pulmonary Disease'. Respiration, . Available Online [Details]
Riha, R. L.,McNicholas, W. T.; (2009) 'The genetic and cardiovascular aspects of obstructive sleep apnoea/hypopnoea syndrome'. Eur Respir J, 33 (2):233-6. Available Online [Details]
Garvey, J. F.,Taylor, C. T.,McNicholas, W. T.; (2009) 'Cardiovascular disease in obstructive sleep apnoea syndrome: the role of intermittent hypoxia and inflammation'. Eur Respir J, 33 (5):1195-205. Available Online [Details]
de Chazal P, Heneghan C, McNicholas WT.; (2009) 'Multimodal detection of sleep apnoea using electrocardiogram and oximetry signals'. Philosophical transactions. Series A, Mathematical, physical, and engineering sciences, 367 (1887):369-389. [Details]
McNicholas WT, ; (2009) 'Chronic obstructive pulmonary disease and obstructive sleep apnea: overlaps in pathophysiology, systemic inflammation, and cardiovascular disease'. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 180 (8):692-700. [DOI] [Details]
Ryan, S.,Taylor, C. T.,McNicholas, W. T.; (2009) 'Systemic inflammation: a key factor in the pathogenesis of cardiovascular complications in obstructive sleep apnoea syndrome?'. Thorax, 64 (7):631-6. Available Online [Details]
Chua EC, McSharry DG, McNicholas WT, Lowery MM. ; (2009) 'Towards a genioglossus surface EMG model of obstructive sleep apnea'. Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference, 2009:2979-82 . [Details]
Ryan, S.,McNicholas, W. T.; (2008) 'Intermittent hypoxia and activation of inflammatory molecular pathways in OSAS'. Arch Physiol Biochem, 114 (4):261-6. Available Online [Details]
McNicholas, W., , ; (2008) 'Diagnosing the patient at risk of sleep-related respiratory insufficiency'. Multidisciplinary Respiratory Medicine, 3 (1):57-59. [Details]
McNicholas WT, ; (2008) 'Diagnosis of obstructive sleep apnea in adults'. Proceedings of the American Thoracic Society, 2 (NA):154-160. [DOI] [Details]
Dodd JD, Harte S, McNicholas WT, Donnelly SC, ; (2008) 'Honeycomb cysts in idiopathic pulmonary haemosiderosis: high-resolution CT appearances in two adults'. British Journal of Radiology, 81 (972):1-8. [DOI] [Details]
McNicholas WT, Heneghan C, de Chazal P, Ryan S, Chua CP, Doherty L, Boyle P, Nolan P, ; (2008) 'Electrocardiogram recording as a screening tool for sleep disordered breathing'. Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 3 (NA):223-228. [Details]
Heneghan, C.,Chua, C. P.,Garvey, J. F.,de Chazal, P.,Shouldice, R.,Boyle, P.,McNicholas, W. T.; (2008) 'A portable automated assessment tool for sleep apnea using a combined Holter-oximeter'. Sleep, 31 (10):1432-9. Available Online [Details]
O'Connor, C.M., Lowery, M., Doherty, L.S., McHugh, M., O' Muircheartaigh, C., Cullen, J., Nolan, P.J., McNicholas, W.T., and O' Malley, M.J.; (2007) 'Analysis of surface EMG electrode configuration for measuring human genioglossus activity during force varying and fatiguing contractions'. Respiratory Physiology & Neurobiology, . [Details]
Ryan, S, Ward, S, Heneghan, C, McNicholas, WT, ; (2007) 'Predictors of decreased spontaneous baroreflex sensitivity in obstructive sleep apnea syndrome'. Chest, 131 :1100-1107. [Details]
McSharry, DG, McElwaine, P, Segadal, L, McNicholas, WT, ; (2007) 'All that wheezes is not asthma'. Lancet, 370 :800-800. [Details]
McNicholas WT, ; (2007) 'Cardiovascular outcomes of CPAP therapy in obstructive sleep apnea syndrome'. American Journal of Physiology - Regulatory Integrative and Comparative Physiology, 4 (NA):1-70. [DOI] [Details]
Alonderis, A.,Barbe, F.,Bonsignore, M.,Calverley, P.,De Backer, W.,Diefenbach, K.,Donic, V.,Fanfulla, F.,Fietze, I.,Franklin, K.,Grote, L.,Hedner, J.,Jennum, P.,Krieger, J.,Levy, P.,McNicholas, W.,Montserrat, J.,Parati, G.,Pascu, M.,Penzel, T.,Riha, R.,Rodenstein, D.,Sanna, A.,Schulz, R.,Sforza, E.,Sliwinski, P.,Tomori, Z.,Tonnesen, P.,Varoneckas, G.,Zielinski, J.,Kostelidou, K.; (2007) 'Medico-legal implications of sleep apnoea syndrome: Driving license regulations in Europe'. Sleep Med, . [Details]
Ryan, S, McNicholas, WT, Taylor, CT, ; (2007) 'A critical role for p38 map kinase in NF-kappa B signaling during intermittent hypoxia/reoxygenation'. Biochemical and Biophysical Research Communications, 355 :728-733. [Details]
Doherty, LS; Kiely, JL; Deegan, PC; Nolan, G; McCabe, S; Green, AJ; Ennis, S; McNicholas, WT; ; (2007) 'Late-onset central hypoventilation syndrome: a family genetic study'. European Respiratory Journal, 29 (2):312-316. [Details]
Ryan, S, Nolan, GM, Hannigan, E, Cunningham, S, Taylor, C, McNicholas, WT, ; (2007) 'Cardiovascular risk markers in obstructive sleep apnoea syndrome and correlation with obesity'. Thorax, 62 :509-514. [Details]
McNicholas WT, Chua CP, Garvey J, Redmond S, Heneghan C, ; (2007) 'Towards automated sleep state estimation using a Holter-oximeter'. Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference, (NA):3998-4001. [DOI] [Details]
O'Connor, C.M., Lowery, M.M., Doherty, L.S., McHugh, M., O'Muircheartaigh, C., Cullen, J., Nolan, P., McNicholas, W.T., and O'Malley M.J.; (2007) 'Improved surface EMG electrode for measuring genioglossus muscle activity'. Respiratory Physiology & Neurobiology, 159 (1):55-67. [Details]
Nolan, G. M.,Doherty, L. S.,Mc Nicholas, W. T.; (2007) 'Auto-adjusting versus fixed positive pressure therapy in mild to moderate obstructive sleep apnoea'. Sleep, 30 (2):189-94. [Details]
Ward, S.,Ryan, S.,Mc Nicholas, W. T.,Heneghan, C.; (2006) 'Comparison of baroreflex sensitivity measures for assessing subjects with Obstructive Sleep Apnea'. Conf Proc IEEE Eng Med Biol Soc, 1 :3572-5. [Details]
McNicholas, WT, Ryan, S, ; (2006) 'Obstructive sleep apnoea syndrome: Translating science to clinical practice'. Respirology, 11 (2):136-144. [Details]
Ryan, S; Taylor, CT; McNicholas, WT; ; (2006) 'Predictors of elevated nuclear factor-kappa B-dependent genes in obstructive sleep apnea syndrome'. American Journal of Respiratory and Critical Care Medicine, 174 (7):824-830. [Details]
Garvey, J.,McNicholas, W. T.; (2006) 'Effect of obesity in patients with coronary artery disease'. Lancet, 368 (9548):1645; aut. [Details]
Doherty LS, Kiely JL Swan V, McNicholas WT.; (2005) 'Long-term effects of nasal CPAP therapy on cardiovascular outcomes in the sleep apnea syndrome'. Chest, 127 (6):2076-2084. [Details]
Ryan, S,Taylor, CT,McNicholas, WT; (2005) 'Selective activation of inflammatory pathways by intermittent hypoxia in obstructive sleep apnea syndrome'. Circulation, 112 :2660-2667. [DOI] [Details]
Doherty LS, Nolan P, McNicholas WT. ; (2005) 'Effects of topical anesthesia on upper airway resistance during wake-sleep transitions'. Journal of Applied Physiology, 99 :549-555. [Details]
Edwards JC, McNicholas WT, Calverley PM, Lee A, ; (2004) 'Long-acting inhaled anticholinergic therapy improves sleeping oxygen saturation in COPD'. EUR RESPIR J, 6 (NA):825-831. [Details]
Ryan, S; McNicholas, WT; O'Regan, RG; Nolan, P; ; (2003) 'Intralaryngeal neuroanatomy of the recurrent laryngeal nerve of the rabbit'. Journal of Anatomy, 202 (5):421-430. [Details]
Martial FP, Dunleavy M, Jones JF, Nolan P, O'Regan RG, McNicholas W, Bradford A. (2003) 'Activity of dorsal medullary respiratory neurons in awake rats'. Advances in Experimental Medical Biology, 536 :445-453. [Details]
Ryan, S,McNicholas, WT,O'Regan, RG,Nolan, P; (2003) 'Upper airway muscle paralysis reduces reflex upper airway motor response to negative transmural pressure in rat'. Journal of Applied Physiology, 94 :1307-1316. [DOI] [Details]
Mc Cabe, S; Doherty, L; McNicholas, WT; Green, AJ; Ennis, S; ; (2003) 'A further locus for congenital central hypoventilation syndrome (CCHS)'. American Journal of Human Genetics, 73 (5):561-561. [Details]
Shouldice, R,Heneghan, C,Nolan, P,Nolan, PG,McNicholas, W; (2002) 'Modulating effect of respiration on atrioventricular conduction time assessed using PR interval variation'. Medical Biological Engineering Computing, 40 :609-617. [Details]
Ryan, S,McNicholas, WT,O'Regan, RG,Nolan, P; (2002) 'Effect of upper airway negative pressure and lung inflation on laryngeal motor unit activity in rabbit'. Journal of Applied Physiology, 92 :269-278. [Details]
Moloney ED, Kiely JL, McNicholas WT. ; (2001) 'Controlled oxygen therapy and carbon dioxide retention during exacerbations of chronic obstructive pulmonary disease'. The Lancet, 357 (9255):526-528. [Details]
McNicholas WT, ; (2001) 'Follow-up and outcomes of nasal CPAP therapy in patients with sleep apnea syndrome'. Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace / Fondazione clinica del lavoro, IRCCS [and] Istituto di clinica tisiologica e malattie apparato respiratorio, Universita di Napoli, Secondo ateneo, 6 (NA):535-539. [Details]
Ryan, S, McNicholas, WT, O'Regan, RG, Nolan, P, ; (2001) 'Reflex respiratory response to changes in upper airway pressure in the anaesthetized rat'. Journal of Physiology, 537 (1):251-265. [DOI] [Details]
Ryan, S, O'Regan, RG, McNicholas, WT, Nolan, P, ; (2000) 'The effect of upper airway muscle relaxation on the laryngeal afferent response to upper airway negative pressure in the anaesthetised rat'. Journal of Physiology, 523 (NA):253-253. [Details]
McNicholas WT, ; (2000) 'Obstructive sleep apnea syndrome: who should be treated?'. Sleep, (NA):1-90. [Details]
McNicholas WT, Harbison J, Dodd J, ; (2000) 'Paradoxical vocal cord motion causing stridor after thyroidectomy'. Thorax, 55 (6):533-534. [Details]
Breathnach, O.,Donnellan, P.,Collins, D.,McNicholas, W.,Crown, J.; (1999) 'Cytomegalovirus pneumonia in a patient with breast cancer on chemotherapy: Case report and review of the literature'. Annals of Oncology, 10 (4):461-465. Available Online [Details]
Donnellan, P.,Armstrong, J.,Rowan, S.,Fennelly, D.,Lynch, V.,McDonnell, T.,McNicholas, W.,Crown, J.; (1998) 'New chemotherapy combinations with docetaxel in the treatment of patients with non-small cell lung cancer'. Seminars in Oncology, 25 (3):20-23. Available Online [Details]
Kiely, JL, Donohoe, P, Bresnihan, B, McNicholas, WT, ; (1998) 'Pulmonary fibrosis in polymyositis with the Jo-1 syndrome: an unusual mode of presentation'. Respiratory Medicine, 92 (9):1167-1169. [Details]
Kiely J, Deegan PC, Buckley A, Shiels P, Maurer BM, McNicholas WT. ; (1998) 'Efficacy of nasal continuous positive airway pressure in chronic heart failure: importance of underlying cardiac rhythm'. Thorax, 53 (11):957-962. [Details]
Kiely, JL; McNicholas, WT; ; (1997) 'Bed partners' assessment of nasal continuous positive airway pressure therapy in obstructive sleep apnea'. Chest, 111 (5):1261-1265. [Details]
Costello, R; Deegan, P; Fitzpatrick, M; McNicholas, WT; ; (1997) 'Reversible hypercapnia in chronic obstructive pulmonary disease: A distinct pattern of respiratory failure with a favorable prognosis'. American Journal of Medicine, 102 (3):239-244. [Details]
Roe, S; Nolan, P; ORegan, RG; McNicholas, WT; ; (1997) 'The effect of prolonged changes in blood gases and pH on performance and fatigue in the upper airway muscles of the anaesthetized rat'. Journal of Physiology, 501P (NA):63-63. [Details]
Deegan, PC,Nolan, P,Carey, M,McNicholas, WT; (1996) 'Effects of positive airway pressure on upper airway dilator muscle activity and ventilatory timing'. Journal of Applied Physiology, 81 :470-479. [Details]
Deegan, PC; McNicholas, WT; ; (1996) 'Predictive value of clinical features for the obstructive sleep apnoea syndrome'. European Respiratory Journal, 9 (1):117-124. [Details]
Mulloy, E; McNicholas, WT; ; (1996) 'Ventilation and gas exchange during sleep and exercise in severe COPD'. Chest, 109 (2):387-394. [Details]
Donohoe, P,McNicholas, WT; (1996) 'An unusual cause of orthopnoea'. Postgraduate Medical Journal, 72 :439-440. [Details]
DEEGAN, PC; MCGLONE, B; MCNICHOLAS, WT; ; (1995) 'TREATMENT OF ROBIN-SEQUENCE WITH NASAL CPAP'. Journal of Laryngology and Otology, 109 (4):328-330. [Details]
DEEGAN, PC,MULLOY, E,MCNICHOLAS, WT; (1995) 'TOPICAL OROPHARYNGEAL ANESTHESIA IN PATIENTS WITH OBSTRUCTIVE SLEEP-APNEA'. American Journal of Respiratory and Critical Care Medicine, 151 :1108-1112. [Details]
DEEGAN, PC; MCNICHOLAS, WT; ; (1995) 'EFFECTS OF (NCPAP) ON CARDIAC-FUNCTION AWAKE AND ASLEEP'. Journal of Sleep Research, 4 (NA):59-63. [Details]
DEEGAN, PC; MCNICHOLAS, WT; ; (1995) 'PATHOPHYSIOLOGY OF OBSTRUCTIVE SLEEP-APNEA'. European Respiratory Journal, 8 (7):1161-1178. [Details]
MCNICHOLAS, WT,COFFEY, M,BOYLE, T; (1993) 'EFFECTS OF NASAL AIR-FLOW ON BREATHING DURING SLEEP IN NORMAL HUMANS'. American Review of Respiratory Disease, 147 :620-623. [Details]
MULLOY, E,MCNICHOLAS, WT; (1993) 'THEOPHYLLINE IMPROVES GAS-EXCHANGE DURING REST, EXERCISE, AND SLEEP IN SEVERE CHRONIC OBSTRUCTIVE PULMONARY-DISEASE'. American Review of Respiratory Disease, 148 :1030-1036. [Details]
NOLAN, P; ODONNELL, J; DEEGAN, PC; OREGAN, RG; MCNICHOLAS, WT; ; (1993) 'ROLE OF CORTICAL AROUSAL IN THE VENTILATORY RESPONSE TO AIRWAY OCCLUSION DURING SLEEP'. American Review of Respiratory Disease, 147 (4):514-514. [Details]
DEEGAN, PC; NOLAN, P; OREGAN, RG; MCNICHOLAS, WT; ; (1993) 'EFFECTS OF CONTINUOUS AND EXPIRATORY POSITIVE AIRWAY PRESSURE ON ALAE-NASI AND GENIOGLOSSUS MUSCLE-ACTIVITY IN AWAKE NORMAL HUMANS'. American Review of Respiratory Disease, 147 (4):767-767. [Details]
NOLAN, P; BODKIN, S; DEEGAN, PC; OREGAN, RG; MCNICHOLAS, WT; ; (1993) 'EFFECTS OF BACKGROUND RESISTIVE LOADING ON UPPER AIRWAY RESPONSES TO EXTERNAL INSPIRATORY RESISTIVE LOADS'. American Review of Respiratory Disease, 147 (4):765-765. [Details]
MCNALLY, E; FITZPATRICK, M; BOURKE, S; COSTELLO, R; MCNICHOLAS, WT; ; (1993) 'REVERSIBLE HYPERCAPNIA IN ACUTE EXACERBATIONS OF CHRONIC OBSTRUCTIVE PULMONARY-DISEASE (COPD)'. European Respiratory Journal, 6 (9):1353-1356. [Details]
MULLOY, E; MCNICHOLAS, WT; ; (1992) 'THEOPHYLLINE IN OBSTRUCTIVE SLEEP-APNEA - A DOUBLE-BLIND EVALUATION'. Chest, 101 (3):753-757. [Details]
KEANE, D; MCNICHOLAS, WT; ; (1992) 'COMPARISON OF NEBULIZED AND SPRAYED TOPICAL ANESTHESIA FOR FIBEROPTIC BRONCHOSCOPY'. European Respiratory Journal, 5 (9):1123-1125. [Details]
COFFEY, MJ; FITZGERALD, MX; MCNICHOLAS, WT; ; (1991) 'COMPARISON OF OXYGEN DESATURATION DURING SLEEP AND EXERCISE IN PATIENTS WITH CYSTIC-FIBROSIS'. Chest, 100 (3):659-662. [Details]
CHADWICK, GA; CROWLEY, P; FITZGERALD, MX; OREGAN, RG; MCNICHOLAS, WT; ; (1991) 'OBSTRUCTIVE SLEEP-APNEA FOLLOWING TOPICAL OROPHARYNGEAL ANESTHESIA IN LOUD SNORERS'. American Review of Respiratory Disease, 143 (4):810-813. [Details]
MCNICHOLAS, WT,COFFEY, M,MCDONNELL, T,OREGAN, R,FITZGERALD, MX; (1987) 'UPPER AIRWAY-OBSTRUCTION DURING SLEEP IN NORMAL SUBJECTS AFTER SELECTIVE TOPICAL OROPHARYNGEAL ANESTHESIA'. American Review of Respiratory Disease, 135 :1316-1319. [Details]
McNicholas WT, Coffey M, McDonnell T, O'Regan R, FitzGerald MX. ; (1987) 'Upper airway obstruction during sleep in normal subjects after selective topical anesthesia'. American Review of Respiratory Disease, 135 (6):1316-1319. [Details]
Hannon VM, Cunningham AJ, Hutchinson M, McNicholas W (1986) 'Aspiration pneumonia and coma--an unusual presentation of dystrophic myotonia'. Canadian Anaesthetists Society Journal, 33 (6):803-806. [Details]
Goldstein RS, Ramcharan V, Bowes G, McNicholas WT, Bradley D, Phillipson EA.; (1984) 'Effects of supplemental oxygen on gas exchange during sleep in patients with severe obstructive lung disease'. New England Journal of Medicine, 310 (7):425-429. [Details]
Rivlin J, Hoffstein V, Kalbfleisch J, McNicholas W, Zamel N, Bryan AC. (1984) 'Upper airway morphology in patients with idiopathic obstructive sleep apnea'. American Review of Respiratory Disease, 129 (3):355-360. [Details]
 

Conference Publications

5. McSharry D.G., McNicholas C., Lowery M.M., O'Connor C., Langran S., O'Sullivan M. and McNicholas W.T. ; (2009) Measurement of genioglossus fatigue in obstructive sleep apnoea syndrome patients and control American Thoracic Society International Conference [Details]
1. Chua C.P., McSharry D.G., McNicholas W.T. and Lowery M.M. ; (2009) Towards a Genioglossus Surface EMG Model of Obstructive Sleep Apnea IEEE Engineering in Medicine and Biology Conference [Details]
McSharry D., Lowery M., O'Sullivan M., O'Connor C., Langran S. and McNicholas W. ; (2008) Validation of a novel surface electrode array to measure genioglossus fatigability  European Respiratory Society Annual Congress, Berlin, Oct. 2008 [Details]
McNicholas, W (2008) MULTIDISCIPLINARY RESPIRATORY MEDICINE Diagnosing the patient at risk of sleep-related respiratory insufficiency , pp.57-59 [Details]
Heneghan, C., Shouldice, R., Nolan, P., Sheridan, E, OMalley, M. J., Nolan, P. G., Cullen, J. and McNicholas, W.; (2001) Independent autonomic modulation of the sinoatrial and atrioventricular nodes assessed through RR and PR interval variation Proceedings of Computers in Cardiology, Rotterdam, Sept. 2001 Rotterdam, , pp.205-208 [Details]
Cullen, J., Lowery, M., McNicholas, W., Nolan, P., OMalley, M. J. and OMuircheartaigh, C.,; (2001) Optimisation of electrode design to detect myoelectric manifestations of fatigue in human genioglossus muscle XXXIV International Congress of Physiological Sciences, Christchurch, New Zealand, August 2001 Christchurch, New Zealand, [Details]
Sheridan, E., Heneghan, C., OMalley, M.J., Nolan, P., McNicholas, W, Cullen, J. P., Nolan, P.G.; (2001) Characterization of autonomic nervous influences on PR and RR intervals in the electrocardiogram Proceedings of the 23rd Annual International Conference of the IEEE Eng. Med. Biol. Soc. Istanbul, Turkey, vol. 1, October, 2001 Istanbul, Turkey, , pp.540-543 [Details]
McHugh, M., Cullen, J., McNicholas, W., Nolan, P., and OMalley, M. J.; (1999) Muscle force and EMG measurement in an upper airway muscle Proceedings of the XVIIth Congress of the International Society of Biomechanics, p. 883, Calgary, Canada, August, 1999 Calgary, Canada, [Details]
   

Editorial

Bonsignore MR, Randerath W;Riha R;Smyth D;Gratziou C;Goncalves M;McNicholas WT (2016) New rules on driver licensing for patients with obstructive sleep apnoea: EU Directive 2014/85/EU. Editorial [DOI] [Details]
McNicholas, WT,Levy, P; (2011) Portable monitoring in sleep apnoea: the way forward?. Editorial [DOI] [Details]
Riha, RL,McNicholas, WT; (2009) The genetic and cardiovascular aspects of obstructive sleep apnoea/hypopnoea syndrome. Editorial [DOI] [Details]
T McNicholas, W; (2006) Optimizing continuous positive airway pressure therapy for obstructive sleep apnea syndrome. Editorial [Details]
                 

Abstract

QUIGLEY, C,DONAGHY, D,MULLOY, E,MCNICHOLAS, W (1992) AUDIT OF PATIENT EDUCATION IN ASTHMA MANAGEMENT. Abstract [Details]
                                                               

Research

Research Interests

Laboratory research interests include the pathophysiology, treatment and outcomes of obstructive sleep apnoea syndrome (OSA), the cardiovascular and metabolic consequences of the disorder, basic cell and molecular mechanisms and consequences of intermittent hypoxia, in addition to sleep disturbances in COPD and other chronic respiratory disorders. The laboratory is also closely involved in the evaluation of novel ambulatory monitoring devices for sleep disorders.

Over the past decade, our group has established a comprehensive translational research programme on the mechanisms and consequences of intermittent hypoxia that includes a novel in vitro cell culture model of intermittent hypoxia, an established rodent model of intermittent hypoxia, and a human model based on carefully selected patient cohorts of patients with OSA.

Current projects include the mechanisms of nocturnal hypertension in OSA and the interactions of intermittent hypoxia with adipose tissue in the pathogenesis of metabolic dysfunction.
These research interests are pursued in collaboration with several other UCD investigators including Prof. Cormac Taylor (UCD Conway Institute), Prof. Donal O'Shea (Obesity and Immunology Research Group) and Prof. Ken McDonald (Heart Failure Research Group). The evaluation of novel monitoring devices is performed in collaboration with BiancaMed, a UCD spin-off company, now a division of ResMed International. 

In recent years, a collaboration has been established by one of our group, Dr. Silke Ryan, with colleagues in the University of Grenoble, France, which has significantly enhanced the translational nature of our research by adding a rodent model of intermittent hypoxia to our existing in vitro model located in UCD Conway Institute and our human model based on patient cohorts selected from the sleep clinic at St. Vincent¿s.
Other major interests include driving safety in OSA and Prof. McNicholas has taken a lead role in the development of new EU guidelines that led to a revision of Annex III of the EU Driving License regulations for patients with OSA.
Our group is also a lead centre in the European Sleep Apnoea Database project that currently includes over 18,000 patients from over 20 academic centres throughout Europe and represents the largest global database of patients with OSA.
Our group currently holds two HRB research grants, both of which will run until 2015/16.
FUNDING AGENCIES:
Heath Research Board
European Union
Enterprise Ireland

UCD Medicine Research Individual Investigator 

                      

Research Projects

Sponsor : Health Research Board (HRB)
Title : Role of nitric oxide in modulating inflammatory pathways during intermittent hypoxia
Start Date / End Date : 01-JUL-09 / 30-JUN-12
Sponsor : AstraZeneca Pharmaceuticals Ltd., Ireland
Title : Obesity and Obstructive Sleep Apnoea: Cardiovascular, Metabolic and Inflammatory Association
Start Date / End Date : 01-JUL-09 / 30-JUN-11
Sponsor : Health Research Board (HRB)
Title : Obstructive Sleep Apnoea Syndrome As an Important Cause of Non-dipping Hypertension - Prevalence and Mechanistic Insights
Start Date / End Date : 01-JAN-13 / 30-JUN-16
 

Current Postgraduate Students

Sophie Crinion, Doctor of Philosophy (PhD)   -   Thesis Supervisor

Collaborators

Internal Collaborators

Prof. Cormac Taylor

Prof. Ken McDonald

Prof. Donal O¿Shea

Prof. Jonathan Dodd

External Collaborators

Prof. Jean Louis Pepin/Dr. Claire Arnaud,

University of Grenoble, France

Prof. Jan Hedner and European Sleep Apnoea Database Collaborators,

University of Gothenburg, Sweden

Prof. Maria Bonsignore,

University of Palermo, Italy