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Researchers at UCD

Padraig MacMathuna

School of Medicine & Medical Science

Tel: +353 1 716
Email: pmacmathuna@mater.ie

Biography

1981 UCD graduate with training in Ireland, London and Boston in Gastroenterology. Appointed Consultant Gastroenterologist to Mater University Hospital in 1995.  Track record in clinical and laboratory research in areas from Colon Cancer biology, CT Colon Imaging, High Risk colorectal Cancer screening and endoscopic intervention. Research grant funding from  Irish Cancer Society, HRB and SFI. Recently appointed Associate Professor of Medicine in recognition of contribution to the postgraduate (Former Postgraduate Dean) and undergraduate academic activity of the Mater and UCD. Currently a member of the NCSS Advisory group on Colorectal Cancer Screening and a participant in the NCSS Expert Group on Herediary Cancer Risk. 

Publications

     

Peer Reviewed Journals

Bennett G, Sadlier D, Doran PP, Macmathuna P, Murray DW; (2011) 'A functional and transcriptomic analysis of NET1 bioactivity in gastric cancer'. BMC Cancer, 11 . [DOI] [Details]
Lawlor G, Doran PP, MacMathuna P, Murray DW; (2010) 'MYEOV (myeloma overexpressed gene) drives colon cancer cell migration and is regulated by PGE2'. Clinical Cancer Research, 29 . [DOI] [Details]
Adány R, Dubois PC, Trynka G, Franke L, Hunt KA, Romanos J, Curtotti A, Zhernakova A, Heap GA, Aromaa A, Bardella MT, van den Berg LH, Bockett NA, de la Concha EG, Dema B, Fehrmann RS, Fernández-Arquero M, Fiatal S, Grandone E, Green PM, Groen HJ, Gwilliam R, Houwen RH, Hunt SE, Kaukinen K, Kelleher D, Korponay-Szabo I, Kurppa K, MacMathuna P, Mäki M, Mazzilli MC, McCann OT, Mearin ML, Mein CA, Mirza MM, Mistry V, Mora B, Morley KI, Mulder CJ, Murray JA, Núñez C, Oosterom E, Ophoff RA, Polanco I, Peltonen L, Platteel M, Rybak A, Salomaa V, Schweizer JJ, Sperandeo MP, Tack GJ, Turner G, Veldink JH, Verbeek WH, Weersma RK, Wolters VM, Urcelay E, Cukrowska B, Greco L, Neuhausen SL, McManus R, Barisani D, Deloukas P, Barrett JC, Saavalainen P, Wijmenga C, van Heel DA (2010) 'Multiple common variants for celiac disease influencing immune gene expression'. Nature Genetics, 42 (4):295-302. [DOI] [Details]
Brophy K, Ryan AW, Turner G, Trimble V, Patel KD, O'Morain C, Kennedy NP, Egan B, Close E, Lawlor G, MacMathuna P, Stevens FM, Abuzakouk M, Feighery C, Kelleher D, McManus R (2010) 'Evaluation of 6 candidate genes on chromosome 11q23 for coeliac disease susceptibility: a case control study'. BMC Medical Genetics, 11 . [DOI] [Details]
Harewood G, Byrne S, Clarke E, Lennon J, MacMathuna P, Coss A, O'Donovan D, ; (2009) 'Knowledge of the indications for endoscopic ultrasound (EUS) among gastroenterologists and non-gastroenterologists'. Irish Medical Journal, 102 (2):50-52. [Details]
Bennett, G.Bennett, G.,Murray, D. W.Murray, D. W.,Mac Mathuna, P.Mac Mathuna, P.,Doran, P.Doran, P.; (2009) 'NET1: A Potent Promoter of Gastric Cancer - Characterisation of Gene Expression Profile Using a Novel Gene Knockdown Model'. GastroenterologyGastroenterologyGastroenterology, 136 (55). Available Online [Details]
Doran P, Murray D, Horgan G, Macmathuna P, ; (2008) 'NET1-mediated RhoA activation facilitates lysophosphatidic acid-induced cell migration and invasion in gastric cancer'. Cancer, 99 (8):1322-1329. [DOI] [Details]
Anquetin, G.Anquetin, G.,Horgan, G.Horgan, G.,Rawe, S.Rawe, S.,Murray, D.Murray, D.,Madden, A.Madden, A.,MacMathuna, P.MacMathuna, P.,Doran, P.Doran, P.,Murphy, P. V.Murphy, P. V.; (2008) 'Synthesis of novel macrolactam and macroketone analogues of migrastatin from D-glucal and comparison with macrolactone and acyclic analogues: A dorrigocin A congener is a potent inhibitor of gastric cancer cell migration'. European Journal of Organic ChemistryEuropean Journal of Organic ChemistryEuropean Journal of Organic Chemistry, (1111):1953-19581953. Available Online [Details]
Horgan, G., Murray, D., Madden, A., Bennett, G., Anquetin, G., Murphy, P., Lennon, J., MacMathuna, P., Doran, P., ; (2008) 'Gastric cancer cell migration is reduced by novel migrastatin analogues'. Gut, 57 :23-24. [Details]
Anquetin, G., Horgan, G., Rawe, S., Murray, D., Madden, A., MacMathuna, P., Doran, P., Murphy, P. V., ; (2008) 'Synthesis of novel macrolactam and macroketone analogues of migrastatin from D-glucal and comparison with macrolactone and acyclic analogues: A dorrigocin A congener is a potent inhibitor of gastric cancer cell migration'. European Journal of Organic Chemistry, (11):1953-1958. [Details]
Doran P, Murray D, Horgan G, Macmathuna P, ; (2008) 'NET1-mediated RhoA activation facilitates lysophosphatidic acid-induced cell migration and invasion in gastric cancer'. British Journal of Cancer, 8 (NA):1322-1329. [DOI] [Details]
Moss, A. C.,Morris, E.,Leyden, J.,MacMathuna, P.; (2007) 'Malignant distal biliary obstruction: a systematic review and meta-analysis of endoscopic and surgical bypass results'. Cancer Treat Rev, 33 (2):213-21. [Details]
Moss, A. C.,Morris, E.,Leyden, J.,Macmathuna, P.; (2007) 'Do the benefits of metal stents justify the costs? A systematic review and meta-analysis of trials comparing endoscopic stents for malignant biliary obstruction'. Eur J Gastroenterol Hepatol, 19 (12):1119-24. [Details]
Murray, D. W.Murray, D. W.,Macmathuna, P.Macmathuna, P.,Doran, P.Doran, P.; (2007) 'Netl, a novel gastric adenocarcinoma-associated gene, drives tumor migration and invasion via cytoskeletal rearrangement events'. GastroenterologyGastroenterologyGastroenterology, 132 (44). Available Online [Details]
Moss AC, Murray D, Doran P, MacMathuna P, ; (2007) 'In silico gene expression analysis--an overview'. Cancer, 6 . [DOI] [Details]
Madden A, Murray D, Murphy PV, Anquetin G, MacMathuna P and Doran P; (2007) 'Novel Migrastatin Analogues and Gastric Cancer Cell Migration'. IRISH JOURNAL OF MEDICAL SCIENCE, 176 (13). [Details]
MacMathuna P, Moss AC, Morris E, Leyden J, ; (2007) 'Malignant distal biliary obstruction: a systematic review and meta-analysis of endoscopic and surgical bypass results'. Cancer, 33 (2):213-221. [DOI] [Details]
Murray, D.,Doran, P.,MacMathuna, P.,Moss, A. C.; (2007) 'In silico gene expression analysis--an overview'. Mol Cancer, 6 . [Details]
Gleeson, F.,Clarke, E.,Lennon, J.,MacMathuna, R.,Crowe, J.; (2006) 'Outcome of accident and emergency room triaged patients with low risk non-variceal upper gastrointestinal haemorrhage'. Ir Med J, 99 (4):114-7. [Details]
Lowlor, G.Lowlor, G.,Moss, A.Moss, A.,Tighe, D.Tighe, D.,Murray, D. W.Murray, D. W.,O'Keane, C.O'Keane, C.,Doran, P.Doran, P.,MacMathuna, P.MacMathuna, P.; (2006) 'Functional significance of enhanced ETV4 and MYEOV expression in colorectal neoplasia using sirna-mediated gene knockdown'. GastroenterologyGastroenterologyGastroenterology, 130 (44). Available Online [Details]
MacMathuna P, Leyden J, Murray D, Moss A, Arumuguma M, Doyle E, McEntee G, O'Keane C, Doran P, ; (2006) 'Net1 and Myeov: computationally identified mediators of gastric cancer'. Cancer, 94 (8):1204-1212. [DOI] [Details]
Leyden, J., Murray, D., Moss, A., Arumuguma, M., Doyle, E., McEntee, G., O'Keane, C., Doran, P MacMathuna, P.; (2006) 'Net1 and Myeov: computationally identified mediators of gastric cancer'. BRITISH JOURNAL OF CANCER, 94 (8):1204-1212. [Details]
Leyden, J; Murray, D; Moss, A; Arumuguma, M; Doyle, E; McEntee, G; O'Keane, C; Doran, P; MacMathuna, P; ; (2006) 'Net1 and Myeov: computationally identified mediators of gastric cancer'. British Journal of Cancer, 94 (8):1204-1212. [Details]
Canny, G,Drudy, D,MacMathuna, P,O'Farrelly, C,Baird, AW; (2006) 'Toxigenic C-difficile induced inflammatory marker expression by human intestinal epithelial cells is asymmetrical'. Life Sciences, 78 :920-925. [DOI] [Details]
Canny, G; Drudy, D; MacMathuna, P; O'Farrelly, C; Baird, AW; ; (2006) 'Toxigenic C-difficile induced inflammatory marker expression by human intestinal epithelial cells is asymmetrical'. Life Sciences, 78 (9):920-925. [Details]
Moss AC and Lawlor G, Murray D, Tighe D, Madden SF, Mulligan AM, Keane CO, Brady HR, Doran PP and MacMathuna P ; (2006) 'ETV4 and Myeov knockdown impairs colon cancer cell line proliferation and invasion'. Biochemical and biophysical research communications, 345 (1):216-221. [DOI] [Details]
Murray, D. W.Murray, D. W.,Leyden, J.Leyden, J.,McEntee, G.McEntee, G.,O'Keane, C.O'Keane, C.,MacMathuna, P.MacMathuna, P.,Doran, P.Doran, P.; (2006) 'NET1 - A novel activator of RhoA and gastric cancer cell invasion'. GastroenterologyGastroenterologyGastroenterology, 130 (44). Available Online [Details]
Leyden, J.Leyden, J.,Murray, D.Murray, D.,Moss, A.Moss, A.,Arumuguma, M.Arumuguma, M.,Doyle, E.Doyle, E.,McEntee, G.McEntee, G.,O'Keane, C.O'Keane, C.,Doran, P.Doran, P.,MacMathuna, P.MacMathuna, P.; (2006) 'Net1 and Myeov: computationally identified mediators of gastric cancer'. British Journal of CancerBritish Journal of CancerBritish Journal of Cancer, 94 (88):1204-12121204. Available Online [Details]
Moss AC, Morris E, Mac Mathuna P.; (2006) 'Palliative biliary stents for obstructing pancreatic carcinoma'. Cochrane Database of Systematic Reviews, . [Details]
Canny, G.,Drudy, D.,Macmathuna, P.,O'Farrelly, C.,Baird, A. W.; (2006) 'Toxigenic C. difficile induced inflammatory marker expression by human intestinal epithelial cells is asymmetrical'. Life Sci, 78 (9):920-5. [Details]
Moss, A. C.,Lawlor, G.,Murray, D.,Tighe, D.,Madden, S. F.,Mulligan, A. M.,Keane, C. O.,Brady, H. R.,Doran, P. P.,MacMathuna, P.; (2006) 'ETV4 and Myeov knockdown impairs colon cancer cell line proliferation and invasion'. Biochem Biophys Res Commun, 345 (1):216-21. [Details]
Leyden, J. E.,Moss, A. C.,MacMathuna, P.; (2006) 'Endoscopic pneumatic dilation versus botulinum toxin injection in the management of primary achalasia'. Cochrane Database Syst Rev, (4). [Details]
Barry, J. Bourke, M. Buckley, M. Coughlan, B. Crowley, D. Cullen, W. Dooley, S. Keating, S. Kelleher, D. Moloney, J. Murray, F. McCormack, PA. MacMathuna, P. O' Connor, J. O' Grady, J. O'Sullivan, C. O'Sullivan, P. Quinn, C. Smyth, B. Sweeney, B.; ; (2004) 'Hepatitis C among drug users: consensus guidelines on management in general practice'. Irish Journal of Medical Science, 173 (3):145-150. [Details]
O'Connor, A,Leyden, J,McEntee, G,MacMathuna, P; (2004) 'Palliative stenting of recurrent malignancy at gastrojejunostomy anastomotic sites'. IRISH J MED SCI, 173 :219-220. [Details]
Goh, J; Godson, C; Brady, HR; MacMathuna, P; ; (2003) 'Lipoxins: Pro-resolution lipid mediators in intestinal inflammation'. Gastroenterology, 124 (4):1043-1054. [Details]
Goh, J; Otridge, B; Brady, H; Breatnach, E; Dervan, P; MacMathuna, P; ; (2001) 'Aggressive multiple myeloma presenting as mesenteric panniculitis'. American Journal of Gastroenterology, 96 (1):238-241. [Details]
Canny, GO; Drudy, D; Mac Mathuna, P; O'Farrelly, C; Baird, AW; ; (2001) 'Comparison of toxigenic and non toxigenic Clostridium difficile on T84 cell inflammatory phenotype'. Gastroenterology, 120 (5):326-326. [Details]
Goh, J,Baird, AW,O'Keane, C,Watson, RWG,Cottell, D,Bernasconi, G,Petasis, NA,Godson, C,Brady, HR,MacMathuna, P; (2001) 'Lipoxin A(4) and aspirin-triggered 15-epi-lipoxin A(4) antagonize TNF-alpha-stimulated neutrophil-enterocyte interactions in vitro and attenuate TNF-alpha-induced chemokine release and colonocyte apoptosis in human intestinal mucosa ex vivo'. J IMMUNOL, 167 :2772-2780. [Details]
Clarke, GA,Ryan, E,Crowe, JP,O'Keane, JC,MacMathuna, P; (2001) 'Tumour-derived mutated K-ras codon 12 expression in regional lymph nodes of stage II colorectal cancer patients is not associated with increased risk of cancer-related death'. Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland, 16 :108-111. [Details]
Clarke, G,Ryan, E,O'Keane, JC,Crowe, J,MacMathuna, P; (2000) 'The detection of cytokeratins in lymph nodes of Duke's B colorectal cancer subjects predicts a poor outcome'. Gastroenterology, 12 :549-552. [Details]
Goh, J; Baird, AW; Watson, WR; Godson, C; O'Keane, C; Brady, HR; MacMathuna, P; ; (2000) 'Lipoxins attenuate TNF-A-induced apoptosis in human colonic mucosa'. Gastroenterology, 118 (4):806-806. [Details]
MACMATHUNA, P,WHITE, P,CLARKE, E,MERRIMAN, R,LENNON, JR,CROWE, J; (1995) 'ENDOSCOPIC BALLOON SPHINCTEROPLASTY (PAPILLARY DILATION) FOR BILE-DUCT STONES - EFFICACY, SAFETY, AND FOLLOW-UP IN 100 PATIENTS'. Gastrointestinal Endoscopy, 42 :468-474. [Details]
MACMATHUNA, P,LENNON, J,CROWE, J; (1993) 'ENDOSCOPIC BALLOON SPHINCTEROPLASTY FOR BENIGN PAPILLARY STENOSIS - AN ALTERNATIVE TO SURGICAL OR ENDOSCOPIC PAPILLOTOMY'. IRISH J MED SCI, 162 :355-357. [Details]
MACMATHUNA, P,VLAVIANOS, P,WESTABY, D,WILLIAMS, R; (1992) 'PATHOPHYSIOLOGY OF PORTAL-HYPERTENSION'. Digestive Diseases, 10 :3-15. [Details]
 

Conference Publications

Horgan H, Murray D, Madden A, Bennett B, Anquetin G, Murphy P, Lennon J, MacMathuna P and Doran P; (2008) Gastric Cancer Cell Migration Is Reduced By Novel Migrastatin Analogues British Gastroenterology Meeting [Details]
Horgan G, Murray DW, Madden A, Bennett G, Ryan J, Anquetin G, Murphy PV, MacMathuna P and Doran P ; (2008) Novel Migrastatin Analogues Reduce Gastric Cancer Cell Migration Without Exhibiting Cytotoxic Effects American Gastroenterological Association : Digestive Disease Week [Details]
Murray DW, MacMathuna P and Doran P ; (2007) Netl, a novel gastric adenocarcinoma-associated gene, drives tumor migration and invasion via cytoskeletal rearrangement events AGA DDW 07 [Details]
Murray DW, Leyden J, McEntee G, O'Keane C, MacMathuna P and Doran P ; (2006) NET1 - A novel activator of RhoA and gastric cancer cell invasion AGA DDW [Details]
Canny, G, Drudy, D, MacMathuna, P, O'Farrelly, C, Baird, AW, ; (2006) LIFE SCIENCES Toxigenic C-difficile induced inflammatory marker expression by human intestinal epithelial cells is asymmetrical , pp.920-925 [Details]
Lawlor, G., Murray, D, Moss, A., Leyden, J., Sadlier, D., O' Keane, C., Mulligan, AM., Arumuguma, M., Doyle, E., McEntee, G., MacMathuna, P. Doran, P.; (2006) Gastrointestinal Epithelial Cancers ' A Common Gene Expression Profile? The Irish Association for Cancer Research Annual Meeting [Details]
Lawlor, G., Tighe, T.G., Moss, A., Murray, D., Madden, S., Mulligan, A.M., O'Keane, C., Brady, H., Doran, P. MacMathuna, P.; (2006) Functional Significance of Enhanced Etv4 and Myeov Expression in Colorectal Neoplasia using siRNA-Mediated Gene Knockdown Mater Misericordiae University Hospital - Young Investigators Research Symposium [Details]
Lawlor, G., Moss, A., Tighe, D., Murray, D., Madden, S., Mulligan, AM., O'Keane, C., Brady, H., Doran, P. MacMathuna, P.; (2006) Functional Significance of Enhanced Etv4 and Myeov Expression in Colorectal Neoplasia using siRNA-Mediated Gene Knockdown The Irish Association for Cancer Research Annual Meeting [Details]
Lawlor, G., Moss, A., Tighe, D., Murray, D., Madden, S., Mulligan, A.M., O'Keane, C., Brady, H., Doran, P. Mac Mathuna, P.; (2006) Functional Significance of enhanced ETV4 and Myeov Expression in Colorectal Neoplasia using Si-Mediated Gene Knockdown Digestive Diseases Week [Details]
Murray, D., Leyden, J., Arumuguma, M., Doyle, E., McEntee, G., O'Keane, C., MacMathuna, P. Doran, P.; (2006) NET1 - A Novel Activator of RhoA and Gastric Cancer Cell Invasion Mater Misericordiae University Hospital - Young Investigators Research Symposium [Details]
Lowlor G, Moss A, Tighe D, Murray DW, O'Keane C, Doran P and MacMathuna P ; (2006) Functional significance of enhanced ETV4 and MYEOV expression in colorectal neoplasia using sirna-mediated gene knockdown AGA DDW [Details]
Murray, D., Leyden, J., Arumuguma, M., Doyle, E., McEntee, G., O'Keane, C., MacMathuna, P. Doran, P.; (2006) NET1 - A Novel Activator of RhoA and Gastric Cancer Cell Invasion The Irish Association for Cancer Research Annual Meeting [Details]
Murray, D., Leyden, J., Arumuguma, M., Doyle, E., McEntee, G., O'Keane, C., MacMathuna, P. Doran, P.; (2006) NET1 - a novel activator of gastric tumor cell invasion and RhoA The American Association for Cancer Research 97th Annual Meeting [Details]
Murray DW, Leyden J, Arumuguma M, Doyle E, McEntee G, O'Keane C, MacMathuna P, Doran P. ; (2006) NET1 - a novel activator of gastric tumour cell invasion and RhoA American Association for Cancer Research Annual Meeting [Details]
Lawlor, G., Moss, A., Tighe, D., Murray, D., Madden, S., Mulligan, A.M., O'Keane, C., Brady, H., Doran, P. Mac Mathuna, P.; (2005) Functional Significance of Enhanced ETV4 and Myeov expression in Colorectal Neoplasia Irish Society of Gastroenterology [Details]
Murray, D., Leyden, J., Arumuguma, M., Doyle, E., McEntee, G., O'Keane, C., MacMathuna, P. Doran, P.; (2005) NET1 - A Novel Activator of RhoA and Gastric Tumour Cell Invasion The Irish Society of Gastroenterology Annual Meeting [Details]
   

Editorial

Leyden, J,O'Shea, C,Hegarty, S,MacMathuna, P; (2005) An unusual finding in a patient with iron deficiency anaemia. Editorial [DOI] [Details]
MacMathuna, P; (1997) Endoscopic treatment of bile duct stones: Should we cut or dilate the sphincter?. Editorial [Details]