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Aleksandra Miranda Caso Luengo

Post Doc Research Fellow Lvl I

School Of Medicine & Medical Science
Conway Institute
Belfield
Dublin 4

Tel: +353 1 7161625
Email: aleksandra.mirandacasoluengo@ucd.ie

Biography

2013 - present            Postdoctoral Researcher, School of Medicine and Medical Science, UCD, Ireland

2011 - 2012                Research Assistant in the Reproductive Biology Research Cluster, UCD, Ireland

2008 - 2011                Senior Postgraduate Demonstrator, School of Biomolecular and Biomedical Science, UCD

2007 - 2012                PhD in Infection Biology, School of Biomolecular and Biomedical Science, UCD, Ireland

2005 - 2007                MSc in Biotechnology, Uniwersytet Mikolaja Kopernika in Torun, Poland

2002 - 2005                BSc in Biotechnology, Uniwersytet Mikolaja Kopernika in Torun, Poland

Professional

Honours and Awards

Year: 2012.
Title: Prize for the best oral presentation
Year: 2008.
Title: Town Award for Excellent Students
Year: 2007.
Title: Scientific Scholarship for Excellent Students

Associations

Association: Society for General Microbiology, Function/Role: Member
     

Conference Contributions

1. Miranda CasoLuengo A. A., Rodríguez H., Miranda CasoLuengo R., Vázquez Boland J. A. and Meijer W. G. (2012) Lactate metabolism of the pathogenic actinomycete Rhodococcus equi. [Oral Presentation], 5th Havemeyer Workshop, Deauville, France , 09-JUL-12 - 12-JUL-12.
2. Miranda CasoLuengo A. A., Rodríguez H., Miranda CasoLuengo R., Vázquez Boland J. A. and Meijer W. G. (2012) Lactate metabolism of the pathogenic actinomycete Rhodococcus equi. [Oral Presentation], Dublin Academy of Pathogenomics and Infection Biology, Dublin, Ireland , 12-JUN-12 - 12-JUN-12.
Miranda CasoLuengo A. A., Miranda CasoLuengo R. and Meijer W. G. (2011) Lactate Metabolism of the Pathogenic Actinomycete Rhodococcus equi. [Poster Presentation], Dublin Academy of Pathogenomics and Infection Biology, Dublin, Ireland , 14-SEP-11 - 14-SEP-11.
Miranda-CasoLuengo A. A., Miranda-CasoLuengo R., Chen X., Yang J., Tripathi V., Hondalus M. K. and Meijer W. G. (2010) VirS, the orphan response regulator of Rhodococcus equi. [Poster Presentation], Dublin Academy of Pathogenomics and Infection Biology, Dublin, Ireland , 09-DEC-10 - 09-DEC-10.
Miranda-CasoLuengo, A. A., Miranda-CasoLuengo R., Fahey R. J., Fogarty U., Vazquez-Boland J. A., and Meijer W. G. (2009) Rhodococcus equi gene expression intra-macrophage. [Poster Presentation], 15th International Symposium on the Biology of Actinomycetes, Shanghai, China , 20-AUG-09 - 25-AUG-09.
Miranda CasoLuengo R., Miranda CasoLuengo A. A. and Meijer W. G. (2009) Differential iron status in the Rhodococcus equi intracellular compartment for the virulent and avirulent strains. [Poster Presentation], 15th International Symposium on the Biology of Actinomycetes, Shanghai, China , 20-AUG-09 - 25-AUG-09.
Miranda-CasoLuengo, A. A., Miranda-CasoLuengo R., Fahey R. J., and Meijer W. G. (2008) Enumeration of proliferating Rhodococcus equi inside macrophage cells. [Poster Presentation], 4th Havemeyer Workshop, Edinburgh, UK , 13-JUL-08 - 16-JUL-08.
 

Employment

Employer: School of Medicine and Medical Science, University College Dublin
Position: Postdoctoral Research Fellow
Employer: School of Biomolecular and Biomedical Science, University College Dublin
Position: Senior Postgraduate Demonstrator
Employer: Reproductive Biology Research Cluster, University College Dublin
Position: Research Assistant

Education

Year 2012 Institution: University College Dublin, Ireland
Qualification: PhD Subject: Infection Biology
Year 2007 Institution: Uniwersytet Mikolaja Kopernika in Torun, Poland
Qualification: MSc Subject: Biotechnology
Year 2005 Institution: Uniwersytet Mikolaja Kopernika in Torun, Poland
Qualification: BSc Subject: Biotechnology

Languages

Spanish:
English:
Polish:
       

Publications

     

Peer Reviewed Journals

Miranda-Casoluengo R, Miranda-Casoluengo AA, O'Connell EP, Fahey RJ, Boland CA, Vázquez-Boland JA, Meijer WG (2011) 'The vapA co-expressed virulence plasmid gene vcgB (orf10) of the intracellular actinomycete Rhodococcus equi'. Microbiology, 157 (8):2357-2368. Available Online [DOI] [Details]
Miranda-Casoluengo R, Coulson GB, Miranda-Casoluengo A, Vázquez-Boland JA, Hondalus MK, Meijer WG (2012) 'The hydroxamate siderophore rhequichelin is required for virulence of the pathogenic actinomycete Rhodococcus equi'. Infection and Immunity, 80 (12):4106-4114. Available Online [DOI] [Details]
Miranda-CasoLuengo AA, Miranda-CasoLuengo R, Lieggi NT, Luo H, Simpson JC, Meijer WG (2013) 'A real-time impedance based method to assess Rhodococcus equi virulence'. PLoS ONE, 8 (3). Available Online [DOI] [Details]
                                                     

Technical Publication

Miranda-CasoLuengo AA, Miranda-CasoLuengo R, Lieggi NT, Luo H, Simpson JC and Meijer WG (2013) Analysis of macrophage morphology changes following R. equi infection. Technical Publication [Details]
                                     

Research

Research Interests

My doctoral work was focused on unveiling the molecular basis of virulence of the facultative animal and human pathogen Rhodococcus equi. To characterize the mechanisms that facilitate the conversion of this saprophytic microorganism into an intracellular pathogen, I studied signal transduction pathways that coordinate gene expression during macrophage infection, as well as metabolic processes that allow R. equi to thrive on nutrients available within the host environment.

My current research addresses multi-level regulation of gene expression in Mycobacterium abscessus, an environmental microorganism causing a variety of infections, including a pseudotuberculous lung disease. I am also interested in studying the molecular interactions between this pathogen and macrophages during infection. This will help me to characterize the elements and mechanisms that M. abscessus uses to establish a permissive niche inside the host, and thus will point towards novel diagnostics.

     

Teaching

       

Developing as a Teacher

In 2007 I finished a two-year Pedagogical course and was awarded a Teaching Certificate (for second level education) by Uniwersytet Mikolaja Kopernika in Torun, Poland. As part of my training, in September 2005 and 2006 I worked as a teaching assistant in junior and senior high school in Glogow, Poland. I designed and taught lessons in biology and ecology. During my doctoral studies I took an active role as a senior postgraduate demonstrator in numerous Microbiology and Molecular Biology modules in the School of Biomolecular and Biomedical Science, University College Dublin. Modules: MICR20010, MICR20030, MICR20040, MICR30030, MICR30040, BMOL20050 My teaching experience also includes the design of an undergraduate research project and supervising students involved in carrying out required experimental work.