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Researchers at UCD

David Fennelly

Senior Clinical Lecturer

School Of Medicine & Medical Science
St Vincent's Hospital
Elm Park
Dublin 4

Tel: +353 1 716
Email: david.fennelly@ucd.ie

Professional

         

Conference Contributions

E Fox, D Leahy, R Geraghty, H Mulcahy, J Hyland, D Fennelly, D O'Donoghue, K Sheahan; (2007) Transcriptomic profiling may be useful in predicting recurrence in Stage II colorectal cancer. [Poster Presentation (Refereed)], Irish Association for Cancer Research Annual Meeting, Cork, March, 2007 , 02-MAR-07.
E.J.P. Fox, D.T. Leahy, R. Geraghty, A.M. Lennon, D. Keegan, A. White, H.E. Mulcahy, J.M. Hyland, D. Fennelly, D.P. O'Donoghue, K. Sheahan.; (2005) Differential MLH1 promoter hypermethylation in the identification of sporadic mismatch repair-deficient colorectal cancers. [Poster Presentation (Refereed)], United States and Canadian Academy of Pathology Annual Meeting, San Antonio, Texas, USA. February 2005 , 26-FEB-05.
EJ Fox , D T Leahy, A Lennon, R Geraghty, D Keegan, A White, H E Mulcahy, J M Hyland, D Fennelly, D P O`Donoghue, K Sheahan; (2004) MLH1 and MGMT promoter hypermethylation in colorectal cancer. [Oral Presentation], United States and Canadian Academy of Pathology Annual Meeting, Vancouver, March 2004 , 06-MAR-04.
Nolan, I. M., Fox, E. J. P., Moss, C., Leahy, D. T., Geraghty, R., Mulcahy, H. E., Hyland, J. P. M., Fennelly, D., Sheahan, K., O Donoghue D., Argraves, W. S., and Gallagher, W. M. presented by I. M. Nolan.; (2003) Biomarker identification in colon cancer via real-time reverse transcriptase-PCR. [Poster Presentation], Conference on Common Molecular Mechanisms in Inflammation & Malignancy, St. Vincent?s University Hospital, Dublin , 21-NOV-03.
E.J.P. Fox, A.M. Lennon, D.T. Leahy, R. Geraghty, D. Keegan, H.E. Mulcahy, J.M. Hyland, D. Fennelly, D.P. O'Donoghue, K. Sheahan.; (2003) Clinico-pathological Features in the Identification of Cases of Familial Colorectal Cancer. [N/A], Irish Society of Gastroenterology Spring Meeting, Belfast , 06-JUN-03 - 07-JUN-03.
Nolan, I. M., Fox, E. J. P., Moss, C., Leahy, D. T., Geraghty, R., Mulcahy, H. E., Hyland, J. P. M., Fennelly, D., Sheahan, K., O Donoghue D., Argraves, W. S., and Gallagher, W. M. presented by I. M. Nolan.; (2003) Expression levels of fibulin-1 and 4 mRNA in colon cancer tissues determined by real-time quantitative reverse transcriptase-PCR. [Poster Presentation], 3rd Annual Conway Institute Festival of Research, University College Dublin , 10-SEP-03 - 11-SEP-03.
E.J.P. Fox, A.M. Lennon, D.T. Leahy, R. Geraghty, D. Keegan, H.E. Mulcahy, J.M. Hyland, D. Fennelly, D.P. O'Donoghue, K. Sheahan.; (2003) Epigenetic, Immunohistochemical and Microsatellite Marker Analysis of DNA Mismatch Repair Defects in Colorectal Cancer. [N/A], Irish Association for Cancer Research Annual Meeting, Kilkenny , 11-APR-03 - 13-APR-03.
   

Education

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Publications

     

Peer Reviewed Journals

O'Connor, R.,O'Leary, M.,Ballot, J.,Collins, C. D.,Kinsella, P.,Mager, D. E.,Arnold, R. D.,O'Driscoll, L.,Larkin, A.,Kennedy, S.,Fennelly, D.,Clynes, M.,Crown, J.; (2007) 'A phase I clinical and pharmacokinetic study of the multi-drug resistance protein-1 (MRP-1) inhibitor sulindac, in combination with epirubicin in patients with advanced cancer'. Cancer Chemotherapy and Pharmacology, 59 (1):79-87. Available Online [Details]
Fox, EJ; Leahy, DT; Geraghty, R; Mulcahy, HE; Fennelly, D; Hyland, JM; O'Donoghue, DP; Sheahan, K; ; (2006) 'Mutually exclusive promoter hypermethylation patterns of hMLH1 and O-6-methylguanine DNA methyltransferase in colorectal cancer'. Journal of Molecular Diagnostics, 8 (1):68-75. [Details]
Kelleher, FC, Fennelly, D, Rafferty, M, ; (2006) 'Common critical pathways in embryogenesis and cancer'. Acta Oncologica, 45 (4):375-388. [Details]
Heffernan E, Fennelly D, Collins CD.; (2006) 'Multiple metastases to skeletal muscle from carcinoma of the esophagus detected by FDG PET-CT imaging'. Clinical Nuclear Medicine, 31 :810-811. [Details]
O'Leary, M.,O'Connor, R.,Roy, S.,Ballot, J.,Ooi, W.,Fennelly, D.,Sheehan, L.,Collins, C.,Clynes, M.,Crown, J.; (2004) 'Phase I trial of the multi-drug resistance (MDR) protein-1 (MRP-1) modulating agent sulindac (S) plus epirubicin (E) in patients (pts) with advanced cancer'. Journal of Clinical Oncology, 22 (14):159s-159s. Available Online [Details]
Crown, J.,Fennelly, D.,Collins, C.,Jones, M.,Ennis, S.,Rowan, S.,Flynn, C.,Nutty, S.,Armstrong, J.,Moulton, B.; (2000) 'Mature results of a phase I/II evaluation of docetaxel (T), ifosphamide (I), cisplatin (C) supported by lenograstim (L) in patients (pts) with advanced non-small cell lung cancer (NSCLCa): An Irish Clinical Oncology Research Group (ICORG) study'. Annals of Oncology, 11 :118-119. Available Online [Details]
Crown, J.,Chan, K. M.,O'Leary, M.,Ballot, J.,King, T.,Murphy, J.,Lenehan, P.,Drumm, J.,McCarthy, D.,Fennelly, D.; (1999) 'Feasibility of an accelerated multi-cycle high-dose chemotherapy regimen including high-dose thiotepa for patients (Pts) with poor risk ovarian cancer (OC)'. European Journal of Cancer, 35 :S232-S232. Available Online [Details]
Bourke, T; Carr, A; Fennelly, D; McDermott, E; Crown, J; ; (1998) 'Improved doctor/patient communication indices in oncology: Results of a prospective, controlled evaluation and intervention based on the E4 model'. Annals of Oncology, 9 (NA):141-141. [Details]
Hudis, C.,Seidman, A.,Raptis, G.,Fennelly, D.,Gilewski, T.,Baselga, J.,Theodoulou, M.,Sklarin, N.,Moynahan, M.,Surbone, A.,Currie, V.,Lebwohl, D.,Uhlenhopp, M.,Crown, J.,Norton, L.; (1996) 'Sequential adjuvant therapy: The Memorial Sloan-Kettering Cancer Center experience'. Seminars in Oncology, 23 (1):58-64. Available Online [Details]
Crown, J.,Raptis, G.,Hamilton, N.,Fennelly, D.,Vahdat, L.,Norton, L.; (1995) 'High-Dose Chemotherapy of Breast-Cancer - Current Status and Developmental Strategies'. European Journal of Cancer, 31A (5):809-811. Available Online [Details]
Vahdat, L.,Raptis, G.,Fennelly, D.,Crown, J.; (1995) 'High-Dose Chemotherapy of Metastatic Breast-Cancer - a Review'. Cancer Investigation, 13 (5):505-510. Available Online [Details]
Vahdat, L.,Raptis, G.,Fennelly, D.,Hamilton, N.,Reich, L.,Tiersten, A.,Harrison, M.,Hudis, C.,Moore, M.,Yao, T. J.,Norton, L.,Crown, J.; (1995) 'Rapidly cycled courses of high-dose alkylating agents supported by filgrastim and peripheral blood progenitor cells in patients with metastatic breast cancer'. Clinical Cancer Research, 1 (11):1267-1273. Available Online [Details]
Fennelly, D.,Schneider, J.,Spriggs, D.,Bengala, C.,Hakes, T.,Reich, L.,Barakat, R.,Curtin, J.,Moore, M. A. S.,Hoskins, W.,Norton, L.,Crown, J.; (1995) 'Dose-Escalation of Paclitaxel with High-Dose Cyclophosphamide, with Analysis of Progenitor-Cell Mobilization and Hematologic Support of Advanced Ovarian-Cancer Patients Receiving Rapidly Sequenced High-Dose Carboplatin Cyclophosphamide Courses'. Journal of Clinical Oncology, 13 (5):1160-1166. Available Online [Details]
Fennelly, D.,Wasserheit, C.,Schneider, J.,Hakes, T.,Reich, L.,Curtin, J.,Yao, T. J.,Markman, M.,Norton, L.,Crown, J.; (1994) 'Simultaneous Dose-Escalation and Schedule Intensification of Carboplatin-Based Chemotherapy Using Peripheral-Blood Progenitor Cells and Filgrastim - a Phase-I Trial'. Cancer Research, 54 (23):6137-6142. Available Online [Details]
Fennelly, D.,Vahdat, L.,Schneider, J.,Reich, L.,Hamilton, N.,Hakes, T.,Raptis, G.,Wasserheit, C.,Kritz, A.,Gulati, S.,Markman, M.,Hoskins, W.,Norton, L.,Crown, J.; (1994) 'High-Intensity Chemotherapy with Peripheral-Blood Progenitor-Cell Support'. Seminars in Oncology, 21 (2):21-25. Available Online [Details]
Crown, J.,Vahdat, L.,Fennelly, D.,Francis, P.,Wasserheit, C.,Hudis, C.,Kritz, A.,Schneider, J.,Hamilton, N.,Gilewski, T.,Norton, L.; (1993) 'High-Intensity Chemotherapy with Hematopoietic Support in Breast-Cancer'. Breast Cancer: From Biology to Therapy, 698 :378-388. Available Online [Details]
Bengala, C.,Fennelly, D.,Shapiro, F.,Schneider, J.,Reich, L.,Moore, M. A. S.,Norton, L.,Crown, J.; (1993) 'Taxol (Txl) in Combination with Cyclophosphamide (Ctx) and G-Csf Can Improve the Mobilization of Peripheral-Blood Progenitors Cells (Pbpcs) in Untreated Locally Advanced Ovarian-Cancer - Preliminary-Report'. Blood, 82 (10):A82-A82. Available Online [Details]

Other Journals

Nolan, IM; Fox, EJ; Moss, C; Leahy, DT; Geraghty, R; Mulcahy, HE; Hyland, JP; Fennelly, D; Sheahan, K; O'Donoghue, D; Argraves, WS; Gallagher, WM; ; (2004) 'Fibulin-1 and-4 mRNA expression levels in human colorectal cancer' British Journal of Cancer 91 (NA) :70-70. [Details]

Conference Publications

Fox, EJ; Leahy, DT; Geraghty, R; Lennon, AM; Keegan, D; White, A; Mulcahy, HE; Hyland, JM; Fennelly, D; O'Donoghue, DP; Sheahan, K; ; (2005) LABORATORY INVESTIGATION 85: Suppl. 1, 102A Differential MLH1 promoter hypermethylation in the identification of sporadic mismatch repair-deficient colorectal cancers [Details]
Nolan, IM; Fox, EJ; Moss, C; Leahy, DT; Geraghty, R; Mulcahy, HE; Hyland, JP; Fennelly, D; Sheahan, K; O'Donoghue, D; Argraves, WS; Gallagher, WM; ; (2004) BRITISH JOURNAL OF CANCER 91: Suppl. 1, S70 Fibulin-1 and-4 mRNA expression levels in human colorectal cancer [Details]
                                                                                         

Research

Research Interests

Research Projects

Sponsor : University College Dublin Foundation Ltd.
Title : Newman Fellowship in Colorectal Cancer - Dr Aidan Murphy
Start Date / End Date : 01-JUL-10 / 30-JUN-12
Sponsor : University College Dublin Foundation Ltd.
Title : Importance oflood vessel stability and the vascular environment in governing treatment response to targeted therapies in colorectal cancer patients
Start Date / End Date : 01-MAR-10 / 28-FEB-12
Sponsor : University College Dublin Foundation Ltd.
Title : Importance of mitochondrial random mutations and deletions in governing treatment response to targeted therapies in colorectal cancer patients
Start Date / End Date : 01-MAR-10 / 28-FEB-12